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https://www.readbyqxmd.com/read/29141069/a-novel-multi-targeting-approach-to-treating-hair-loss-using-standardized-nutraceuticals
#1
Patricia K Farris, Nicole Rogers, Amy McMichael, Sophia Kogan
<p>Hair loss is a complicated problem that causes significant concern for those who are affected. Patients seeking medical treatment have limited options that include topical minoxidil and oral finasteride. While these treatments are backed by long term clinical use and research outcomes, many patients find topical minoxidil difficult to incorporate into their daily routine and some are concerned with the side effects associated with finasteride. In the office setting, patients may be treated with more invasive procedures such as platelet-rich plasma injections (PRP) and hair transplantation, treatments that often must be repeated and can lead to a costly investment...
November 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29138503/dihydrotestosterone-levels-at-birth-associate-positively-with-higher-proportions-of-circulating-immature-na%C3%A3-ve-cd5-b-cells-in-boys
#2
Anna-Carin Lundell, Inger Nordström, Kerstin Andersson, Anna Strömbeck, Claes Ohlsson, Åsa Tivesten, Anna Rudin
Boys present with higher proportions of immature/naïve CD5(+) B cells than girls up to 3 years of age. Boys also have higher fractions of regulatory T cells (Tregs) in early infancy, but the mechanisms for these sex-related differences are unknown. In the prospective FARMFLORA follow-up study of 23 boys and 25 girls, we investigated if these immunological differences remained at 8 years of age. We also examined if testosterone or dihydrotestosterone (DHT) levels at birth and at 8 years of age were associated with immune maturation...
November 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29136296/scalp-melanoma-after-anti-hair-loss-mesotherapy
#3
M Arenbergerova, P Arenberger, S Gkalpakiotis, R A Dahmen, E Sticova, A Fialova
Scalp melanoma comprises 3-5% of all cutaneous melanomas. The median age of the patients is 53 years and males are more frequently affected. The scalp melanomas tend to have nodular histology with a higher mitotic rate (>3/mm) and poorer prognosis (1). The risk factors for development of this tumor are still not defined but UV light and baldness may play a significant role (2-4). Mesotherapy is a non-surgical procedure currently being used to combat hair loss and promote hair growth. Usually a mixture of vitamins, minerals, growth factors, DHT blockers and/or stem cells extracts is injected into the dermal layer of skin (5,6)...
November 14, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29129328/insight-on-cytotoxic-effects-of-silver-nanoparticles-alternative-androgenic-transactivation-by-adsorption-with-dht
#4
Jae Soon Kang, June-Woo Park
Silver nanoparticles (AgNPs) are accumulated in the male reproductive organs for a long time and cause several adverse effects in there. Up to now, there is little of information for the cytotoxic effects in male reproductive cells. In this study, the stable AgNPs with a minimal silver ion (Ag(+)) dissolution below concentration inducing cytotoxicity in the cell medium were exposed to the human prostate carcinoma cell line 22Rv1. Moreover particle uptake and androgen receptor (AR) transactivation were evaluated...
November 9, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29122541/the-simultaneous-measurement-of-serum-testosterone-and-5%C3%AE-dihydrotestosterone-by-gas-chromatography-mass-spectrometry-gc-ms
#5
Frank Kannenberg, Manfred Fobker, Erhard Schulte, Grzegorz Pierściński, Reinhard Kelsch, Michael Zitzmann, Jerzy-Roch Nofer, Andreas N Schüring
BACKGROUND: Simultaneous measurement of testosterone (T) and 5α-dihydrotestosterone (DHT) is important for diagnosing androgen deficiency states and hyperandrogenism in males and females, respectively. However, immunoassays used for T and DHT determination suffer from inadequate specificity and sensitivity, while tandem mass spectrometry is expensive and demanding in use. METHODS AND RESULTS: We developed a selective gas chromatography-mass spectrometry (GC-MS) method for parallel T and DHT measurement...
November 6, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29113921/antihypertensive-responses-of-vasoactive-androgens-in-an-in-vivo-experimental-model-of-preeclampsia
#6
Mercedes Perusquía, Andrea E Hanson, Claudia M Meza, Cris Kubli, Nieves Herrera, John N Stallone
Dehydroepiandrosterone (DHEA), testosterone (TES) and its 5-reduced metabolites induce a nongenomic vasorelaxation in several vascular beds of mammals; similarly these hormones produce systemic hypotensive and antihypertensive responses in normotensive and hypertensive male rats. Thus, it was hypothesized that the antihypertensive response of androgens, whose levels are elevated during gestation, protect against gestational hypertension. An animal model of preeclampsia was induced in female Wistar rats using DOCA-salt-treated pregnant (PT) and normal pregnant (NP) rats...
November 4, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29107990/long-lasting-masculinizing-effects-of-postnatal-androgens-on-myelin-governed-by-the-brain-androgen-receptor
#7
Charly Abi Ghanem, Cindy Degerny, Rashad Hussain, Philippe Liere, Antoine Pianos, Sophie Tourpin, René Habert, Wendy B Macklin, Michael Schumacher, Abdel M Ghoumari
The oligodendrocyte density is greater and myelin sheaths are thicker in the adult male mouse brain when compared with females. Here, we show that these sex differences emerge during the first 10 postnatal days, precisely at a stage when a late wave of oligodendrocyte progenitor cells arises and starts differentiating. Androgen levels, analyzed by gas chromatography/tandem-mass spectrometry, were higher in males than in females during this period. Treating male pups with flutamide, an androgen receptor (AR) antagonist, or female pups with 5α-dihydrotestosterone (5α-DHT), revealed the importance of postnatal androgens in masculinizing myelin and their persistent effect into adulthood...
November 6, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/29100889/hormone-dependent-medial-preoptic-lumbar-spinal-cord-autonomic-coordination-supporting-male-sexual-behaviors
#8
REVIEW
Donald W Pfaff, Michael J Baum
Testosterone (T) can act directly through neural androgen receptors (AR) to facilitate male sexual behavior; however, T's metabolites also can play complicated and interesting roles in the control of mating. One metabolite, dihydrotestosterone (DHT) binds to AR with significantly greater affinity than that of T. Is that important behaviorally? Another metabolite, estradiol (E), offers a potential alternative route of facilitating male mating behavior by acting through estradiol receptors (ER). In this review we explore the roles and relative importance of T as well as E and DHT at various levels of the neuroaxis for the activation of male sex behavior in common laboratory animals and, when relevant research findings are available, in man...
October 31, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/29098212/synthesis-and-biological-assessment-of-3-7-dihydroxytropolones
#9
D R Hirsch, D V Schiavone, A J Berkowitz, L A Morrison, T Masaoka, J A Wilson, E Lomonosova, H Zhao, B S Patel, S H Datla, S G Hoft, S J Majidi, R K Pal, E Gallicchio, L Tang, J E Tavis, S F J Le Grice, J A Beutler, R P Murelli
3,7-Dihydroxytropolones (3,7-dHTs) are highly oxygenated troponoids that have been identified as lead compounds for several human diseases. To date, structure-function studies on these molecules have been limited due to a scarcity of synthetic methods for their preparation. New synthetic strategies towards structurally novel 3,7-dHTs would be valuable in further studying their therapeutic potential. Here we describe the successful adaptation of a [5 + 2] oxidopyrilium cycloaddition/ring-opening for 3,7-dHT synthesis, which we apply in the synthesis of a plausible biosynthetic intermediate to the natural products puberulic and puberulonic acid...
November 3, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/29089199/microrna-27a-3p-affects-estradiol-and-androgen-imbalance-by-targeting-creb1-in-the-granulosa-cells-in-mouse-polycytic-ovary-syndrome-model
#10
Mingming Wang, Mei Liu, Jing Sun, Lina Jia, Shuoqian Ma, Jun Gao, Yunyun Xu, Hongwen Zhang, Suk Ying Tsang, Xiangdong Li
Polycystic ovary syndrome (PCOS) is a common endocrine abnormality in women characterized by a menstrual disturbance with chronic anovulation and hyperandrogenism, polycystic ovaries, and insulin resistance. MicroRNAs (miRNAs) are important fine-tune regulators involved in various physiological and pathological processes, but their actions are not fully understood. In this study, we observed the increased expression of miR-27a-3p in the ovaries of mice with PCOS and explored its functions in primary mouse granulosa cells (mGCs) and the mouse granulosa-like tumor cell line, KK-1, using several approaches...
October 28, 2017: Reproductive Biology
https://www.readbyqxmd.com/read/29082495/high-content-positional-biosensor-assay-to-screen-for-compounds-that-prevent-or-disrupt-androgen-receptor-and-transcription-intermediary-factor-2-protein-protein-interactions
#11
Yun Hua, Daniel P Camarco, Christopher J Strock, Paul A Johnston
Transcriptional Intermediary Factor 2 (TIF2) is a key Androgen receptor (AR) coactivator that has been implicated in the development and progression of castration resistant prostate cancer (CRPC). This chapter describes the implementation of an AR-TIF2 protein-protein interaction (PPI) biosensor assay to screen for small molecules that can induce AR-TIF2 PPIs, inhibit the DHT-induced formation of AR-TIF2 PPIs, or disrupt pre-existing AR-TIF2 PPIs. The biosensor assay employs high content imaging and analysis to quantify AR-TIF2 PPIs and integrates physiologically relevant cell-based assays with the specificity of binding assays by incorporating structural information from AR and TIF2 functional domains along with intracellular targeting sequences using fluorescent protein reporters...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29077845/direct-actions-of-androgen-estrogen-and-anti-m%C3%A3-llerian-hormone-on-primate-secondary-follicle-development-in-the-absence-of-fsh-in-vitro
#12
T Baba, A Y Ting, O Tkachenko, J Xu, R L Stouffer
STUDY QUESTION: What are effects of androgen, estrogen and anti-Müllerian hormone (AMH), independent of FSH action, on the development and function of primate follicles from the preantral to small antral stage in vitro? SUMMARY ANSWER: Androgen and estrogen, but not AMH, promote follicle survival and growth in vitro, in the absence of FSH. However, their growth-promoting effects are limited to the preantral to early antral stage. WHAT IS KNOWN ALREADY: FSH supports primate preantral follicle development in vitro...
October 25, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29066868/protective-effect-of-da-9401-in-finasteride-induced-apoptosis-in-rat-testis-inositol-requiring-kinase-1-and-c-jun-n-terminal-kinase-pathway
#13
Kiran Kumar Soni, Yu Seob Shin, Bo Ram Choi, Keshab Kumar Karna, Hye Kyung Kim, Sung Won Lee, Chul Young Kim, Jong Kwan Park
Finasteride is used to treat male pattern baldness and benign prostatic hyperplasia. This study investigated the toxicity of finasteride and recovery by DA-9401 using Sprague Dawley (SD) rats. Forty adult male SD rats were assigned to four groups: control (CTR), finasteride 1 mg/kg/day (F), finasteride 1 mg/kg + DA-9401 100 mg/kg/day (F + DA 100) and finasteride 1 mg/kg + DA-9401 200 mg/kg/day (F + DA 200). Treatments were by oral delivery once daily for 90 consecutive days. The gross anatomical parameters assessed included: genital organ weight; vas deferens sperm count and sperm motility; testosterone, dihydrotestosterone (DHT) and malondialdehyde levels; and histological and terminal deoxynucleotidyl transferase enzyme mediated dUTP nick-end labeling (TUNEL) staining of testis for spermatogenic cell density, Johnsen's score and apoptosis...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29061781/probing-the-oncolytic-and-chemosensitizing-effects-of-dihydrotanshinone-in-an-in-vitro-glioblastoma-model
#14
Varun Kumar, Daniel Radin, Donna Leonardi
BACKGROUND: Temozolomide is the primary chemotherapeutic agent used to treat glioblastoma. However, many tumors are initially resistant to or develop resistance to temozolomide, mainly due to high levels of O(6)-methylguanine DNA transferase (MGMT) which repairs DNA damage traditionally caused by temozolomide. Dihydrotanshinone (DHT) is extracted from Salvia miltiorrhiza, a Chinese medicinal plant, and has also been shown to have antiproliferative effects on various cancer cell lines...
November 2017: Anticancer Research
https://www.readbyqxmd.com/read/29059676/the-androgen-receptor-promotes-cellular-proliferation-by-suppression-of-g-protein-coupled-estrogen-receptor-signaling-in-triple-negative-breast-cancer
#15
Yan Shen, Fang Yang, Wenwen Zhang, Wei Song, Yuxiu Liu, Xiaoxiang Guan
BACKGROUND/AIMS: The targeted therapy for triple-negative breast cancer (TNBC) is still challenging due to poor understanding on its molecular etiology. The androgen receptor (AR) has recently emerged as a prognostic and treatment-predictive marker in breast cancer. However, the role of AR in TNBC remained elusive. METHODS: Immunohistochemistry (IHC) was used to detect AR and G-protein coupled estrogen receptor (GPER) expression in tissue microarrays of 165 TNBC patients...
October 23, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29058684/electrospun-polycaprolactone-nanofibres-decorated-by-drug-loaded-chitosan-nano-reservoirs-for-antibacterial-treatments
#16
Vincenzo Guarino, Iriczalli Cruz Maya, Rosaria Altobelli, Wan Khartini Abdul Khodir, Luigi Ambrosio, Marco A Alvarez Pèrez, Angela Almaguer Flores
Main limitation of conventional antibiotic therapies concerns the low efficacy to bacteria attacks for long treatment times. In this context, the integrated use of electrofluidodynamics (EFDs) - basically electrospinning and electrospraying - may represent an interesting route to design nanostructured platforms with controlled release to prevent the formation of bacterial biofilms in oral implant sites. They allow for the deposition of nanofibres and nanoparticles by different modes - i.e., sequential, simultaneous - for the fabrication of more efficacious systems in terms of degradation protection, pharmacokinetic control and drug distribution to the surrounding tissues...
October 23, 2017: Nanotechnology
https://www.readbyqxmd.com/read/29052817/androgen-signaling-in-esophageal-adenocarcinoma-cell-lines-in-vitro
#17
Helen M Palethorpe, Paul A Drew, Eric Smith
BACKGROUND: We showed previously that nuclear localization of the androgen receptor (AR) and expression of the androgen-responsive gene FK506-binding protein 5 (FKBP5) in esophageal adenocarcinoma (EAC) tissues were associated with decreased patient survival, suggesting a role for androgens in this cancer. AIM: To investigate the effect of the AR ligand 5α-dihydrotestosterone (DHT) on AR-expressing EAC cell lines in vitro. METHODS AND RESULTS: In tissue resection specimens from EAC patients, FKBP5 expression was positively associated with proliferation as measured by Ki-67 expression...
October 20, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29051304/consequences-of-advanced-aging-on-renal-function-in-chronic-hyperandrogenemic-female-rat-model-implications-for-aging-women-with-polycystic-ovary-syndrome
#18
Chetan N Patil, Lorraine C Racusen, Jane F Reckelhoff
Polycystic ovary syndrome (PCOS) is the most common endocrine and reproductive disorder in premenopausal women, characterized by hyperandrogenemia, metabolic syndrome, and inflammation. Women who had PCOS during their reproductive years remain hyperandrogenemic after menopause. The consequence of chronic hyperandrogenemia with advanced aging has not been studied to our knowledge. We have characterized a model of hyperandrogenemia in female rats and have aged them to 22-25 months to mimic advanced aging in hyperandrogenemic women, and tested the hypothesis that chronic exposure to hyperandrogenemia with aging has a deleterious effect on renal function...
November 2017: Physiological Reports
https://www.readbyqxmd.com/read/29042823/digital-health-technology-for-use-in-patients-with-serious-mental-illness-a-systematic-review-of-the-literature
#19
REVIEW
Sonal Batra, Ross A Baker, Tao Wang, Felicia Forma, Faith DiBiasi, Timothy Peters-Strickland
BACKGROUND: As the capabilities and reach of technology have expanded, there is an accompanying proliferation of digital technologies developed for use in the care of patients with mental illness. The objective of this review was to systematically search published literature to identify currently available health technologies and their intended uses for patients with serious mental illness. MATERIALS AND METHODS: The Medline, Embase, and BIOSIS Previews electronic databases were searched to identify peer-reviewed English language articles that reported the use of digital, mobile, and other advanced technology in patients with schizophrenia/schizoaffective disorder, bipolar disorder, and major depressive disorder...
2017: Medical Devices: Evidence and Research
https://www.readbyqxmd.com/read/29037971/to-fight-or-mate-hormonal-control-of-sex-recognition-male-sexual-behavior-and-aggression-in-the-gecko-lizard
#20
Tereza Schořálková, Lukáš Kratochvíl, Lukáš Kubička
Squamate reptiles are a highly diversified vertebrate group with extensive variability in social behavior and sexual dimorphism. However, hormonal control of these traits has not previously been investigated in sufficient depth in many squamate lineages. Here, we studied the hormonal control of male sexual behavior, aggressiveness, copulatory organ (hemipenis) size and sex recognition in the gecko Paroedura picta, comparing ovariectomized females, ovariectomized females treated with exogenous dihydrotestosterone (DHT), ovariectomized females treated with exogenous testosterone (T), control females and males...
October 23, 2017: Hormones and Behavior
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