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https://www.readbyqxmd.com/read/29166518/yellow-dots-in-trichoscopy-relevance-clinical-significance-and-peculiarities
#1
Caren Dos Santos Lima, Luciana Rodino Lemes, Daniel Fernandes Melo
Yellow dots are follicular ostium filled with keratin and/or sebum. Initially, they were exclusively associated with alopecia areata. Currently they have also been described in androgenetic alopecia, chronic cutaneous (discoid) lupus erythematosus, and dissecting cellulitis. Due to the growing importance of trichoscopy and its findings in the evaluation of the scalp, this article describes the main diseases in which yellow dots are a common trichoscopic finding, highlighting its characteristics in each dermatosis...
September 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/29166130/the-clinical-effect-of-jetppeel-assisted-topical-minoxidil-in-the-treatment-of-androgenetic-alopecia-a-randomized-pilot-study
#2
Lin Gong, Linlin Bao, Tian Tian, Yuanhong Li
OBJECTIVE: We used JetPeel, combined with topical minoxidil to treat patients with AGA, in order to observe whether the JetPeel can accelerate the recovery of the disease and find a new method for AGA treatment. METHOD: Thirty patients who met the standard were included in the study. The patients were randomly divided into three groups. The first group was treated with JetPeel-assisted topical minoxidil. The second group received topical minoxidil monotherapy. The third group was not given any treatment...
November 22, 2017: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/29165306/decreased-benzothiazole-type-phemelanin-in-regrown-brown-hair-in-alopecia-areata
#3
Naoki Oiso, Kazumasa Wakamatsu, Shigeto Yanagihara, Akira Kawada
No abstract text is available yet for this article.
November 22, 2017: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/29163335/alopecia-universalis-following-alemtuzumab-treatment-in-multiple-sclerosis-a-barely-recognized-manifestation-of-secondary-autoimmunity-report-of-a-case-and-review-of-the-literature
#4
Julian Zimmermann, Timo Buhl, Marcus Müller
Secondary autoimmunity is the most frequent adverse event occurring in almost every other alemtuzumab-treated multiple sclerosis patient. We report a case of a patient with relapsing-remitting multiple sclerosis who reported smooth, circular areas of complete hair loss on both thighs 6 months after the second treatment cycle with alemtuzumab. The patient was diagnosed as having alopecia areata (AA). Within 3 months, AA progressed to complete loss of all body hair (alopecia universalis). Current literature rarely connects alemtuzumab with the onset of alopecia of autoimmune origin...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29161472/a-young-child-with-fever-alopecia-and-skin-nodules-a-clinicopathological-conference
#5
Pandiarajan Vignesh, Aman Gupta, Deepti Suri, Debajyoti Chatterjee, Uma Nahar Saikia, Amita Trehan, Surjit Singh
The illness started as a continuous high-grade fever noted up to 103°F.. Subsequently, he also developed red painful skin nodules that initially appeared over shins and later progressed to involve thighs, trunks, upper extremities, and face. The nodules also appeared over scalp and there was a was a progressive loss of scalp hair. This article is protected by copyright. All rights reserved.
November 21, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/29159692/germacrone-and-sesquiterpene-enriched-extracts-from%C3%A2-curcuma-aeruginosa-roxb-increase-skin-penetration-of-minoxidil-a-hair-growth-promoter
#6
Jukkarin Srivilai, Neti Waranuch, Anothai Tangsumranjit, Nantaka Khorana, Kornkanok Ingkaninan
Minoxidil is approved for topical treatment of androgenic alopecia but hampered by poor cutaneous absorption. Recently, the randomized control trial showed that hair loss treatment of minoxidil was improved by co-application of the anti-androgen, Curcuma aeruginosa Roxb. extract. Here, we aimed to show that the apparent synergism arises from improved cutaneous penetration of minoxidil by bioactive compound, germacrone or C. aeruginosa (as an n-hexane extract, or essential oil). The partition coefficient of germacrone was determined by HPLC...
November 20, 2017: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/29155099/novel-therapies-for-alopecia-areata-the-era-of-rational-drug-development
#7
Etienne C E Wang, Zhenpeng Dai, Angela M Christiano
The treatments for Alopecia Areata (AA) have evolved over the decades from broad and non-specific therapies, to those that are now more targeted and rationally selected. This was achieved by close co-operation and communication between clinicians and basic scientists, which resulted in the elucidation and understanding of the unique pathophysiology of AA. In this review, we discuss this evolution, and how novel therapies for AA has changed over the decades, what we have in our current arsenal of drugs for this potentially devastating disease, and what the future holds...
November 15, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29152300/gastric-trichobezoar
#8
Daniel José Szor, André Roncon Dias
Trichobezoar is a rare gastrointestinal pathology, but should be considered in patients with abdominal mass and previous history of trichophagia. In physical examination, it is important to verify signs of alopecia. Minimally invasive surgery is a secure method to remove the specimen from the stomach.
November 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/29150291/ruxolitinib-conjugated-gold-nanoparticles-for-topical-administration-an-alternative-for-treating-alopecia
#9
Sanda Boca, Cristian Berce, Ancuta Jurj, Bobe Petrushev, Laura Pop, Grigore-Aristide Gafencu, Sonia Selicean, Vlad Moisoiu, Daiana Temian, Wilhelm-Thomas Micu, Simion Astilean, Cornelia Braicu, Ciprian Tomuleasa, Ioana Berindan-Neagoe
Alopecia is a dermatological condition for which Janus kinase (JAK) inhibitors have recently emerged as potential therapy options, but with limited practical use because of the systemic side effects. The topical use of Ruxolitinib in alopecia universalis has been demonstrated, but little is known about the pharmacodynamics and pharmacokinetics of this way of administration. Nanomedicine provides improved therapeutics. In the current paper we present preliminary data regarding the potential use of Ruxolitinib-conjugated gold nanoparticles (GNPs) in dermatological conditions, as GNPs have been proven to have a reduced absorption rate into the systemic blood flow for cutaneous administration...
November 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/29146897/gwas-for-male-pattern-baldness-identifies-71-susceptibility-loci-explaining-38-of-the-risk
#10
Nicola Pirastu, Peter K Joshi, Paul S de Vries, Marilyn C Cornelis, Paul M McKeigue, NaNa Keum, Nora Franceschini, Marco Colombo, Edward L Giovannucci, Athina Spiliopoulou, Lude Franke, Kari E North, Peter Kraft, Alanna C Morrison, Tõnu Esko, James F Wilson
Male pattern baldness (MPB) or androgenetic alopecia is one of the most common conditions affecting men, reaching a prevalence of ~50% by the age of 50; however, the known genes explain little of the heritability. Here, we present the results of a genome-wide association study including more than 70,000 men, identifying 71 independently replicated loci, of which 30 are novel. These loci explain 38% of the risk, suggesting that MPB is less genetically complex than other complex traits. We show that many of these loci contain genes that are relevant to the pathology and highlight pathways and functions underlying baldness...
November 17, 2017: Nature Communications
https://www.readbyqxmd.com/read/29146216/-nisch-syndrome-a-rare-cause-of-neonatal-cholestasis-a-case-report
#11
S Szepetowski, C Lacoste, S Mallet, B Roquelaure, C Badens, A Fabre
NISCH syndrome is a rare autosomal recessive disease. It is characterized by scalp hypotrichosis, scarring alopecia, ichthyosis, and neonatal sclerosing cholangitis. It is caused by mutations in the CLDN1 gene encoding the claudin-1 protein, which is located at tight junctions. Fifteen cases have been reported to date and three different mutations have been identified. We report on the case of a 2-year-old boy from a consanguineous Moroccan family, presenting with NISCH syndrome and carrying the so-called Moroccan homozygous mutation (c...
November 13, 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/29141068/new-insight-into-the-pathophysiology-of-hair-loss-trigger-a-paradigm-shift-in-the-treatment-approach
#12
Neil S Sadick, Valerie D Callender, Leon H Kircik, Sophia Kogan
<p>Hair loss affects millions of men and women of all ages and ethnicities, impacting appearance, social interactions, and psycho-emotional well-being. Although a number of options are available, they are limited, carry a potential risk of side effects, and none have proven to be comprehensive for treatment of hair loss. Across the spectrum of hair loss disorders, there has long been a segmentation into distinct mechanisms, driving the main trend in current therapeutics to focus on targeting single molecules or pathways...
November 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29139360/vitamin-d-deficiency-in-an-alopecia-referral-clinic-during-a-3-month-period-the-need-to-pursue-systemic-screening
#13
Zuhair Siddiqui, Rashid M Rashid, Paradi Mirmirani
Alopecia is typically viewed as a localized process, and comorbidities are not usually analyzed. The authors examine the prevalence of vitamin D deficiency among patients attending an alopecia clinic during a 3-month period. The data showed that 79% of patients had vitamin D deficiency, and the average value of low vitamin D was 19.1 mg/mL in patients. Vitamin D levels have not been examined extensively in skin disorders, and it is not clear whether vitamin D levels are correlative or causative in alopecia...
2017: Skinmed
https://www.readbyqxmd.com/read/29139043/early-onset-baldness-and-the-risk-of-aggressive-prostate-cancer-findings-from-a-case-control-study
#14
Nathan P Papa, Robert J MacInnis, Dallas R English, Damien Bolton, Ian D Davis, Nathan Lawrentschuk, Jeremy L Millar, Gianluca Severi, John L Hopper, Graham G Giles
PURPOSE: We aimed to evaluate the associations between androgenetic alopecia at a young age and subsequent development of aggressive prostate cancer (PC). METHODS: Using a case-control design with self-administered questionnaire, we evaluated the association between aggressive PC and very early-onset balding at age 20, and early-onset balding at age 40 years in 1,941 men. Cases were men with high-grade and/or advanced stage cancer and controls were clinic based men who had undergone biopsy and were found to be histologically cancer negative...
November 14, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/29138120/recessive-mutation-in-tetraspanin-cd151-causes-kindler-syndrome-like-epidermolysis-bullosa-with-multi-systemic-manifestations-including-nephropathy
#15
Hassan Vahidnezhad, Leila Youssefian, Amir Hossein Saeidian, Hamid Reza Mahmoudi, Andrew Touati, Maryam Abiri, Abdol-Mohammad Kajbafzadeh, Sophia Aristodemou, Lu Liu, John A McGrath, Adam Ertel, Eric Londin, Ariana Kariminejad, Sirous Zeinali, Paolo Fortina, Jouni Uitto
Epidermolysis bullosa (EB) is caused by mutations in as many as 19 distinct genes. We have developed a next-generation sequencing (NGS) panel targeting genes known to be mutated in skin fragility disorders, including tetraspanen CD151 expressed in keratinocytes at the dermal-epidermal junction. The NGS panel was applied to a cohort of 92 consanguineous families of unknown subtype of EB. In one family, a homozygous donor splice site mutation in CD151 (NM_139029; c.351+2T>C) at the exon 5/intron 5 border was identified, and RT-PCR and whole transcriptome analysis by RNA-seq confirmed deletion of the entire exon 5 encoding 25 amino acids...
November 11, 2017: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/29135509/unilesional-follicular-mycosis-fungoides-report-of-6-cases-and-review-of-the-literature
#16
Cynthia M Magro, Gladys H Telang, Shabnam Momtahen
Unilesional follicular mycosis fungoides (MF) is a rare variant of cutaneous T-cell lymphoma characterized by selective involvement of the hair follicles by neoplastic T lymphocytes presenting initially as a solitary lesion occupying less than 5% of the body surface; there are 22 previous reported cases. We describe 6 patients with this rare variant of MF, all males (age range 6-64 years; mean age: 28 years) presenting with a solitary lesion primarily on the face and scalp except 1 patient who presented with a truncal lesion...
October 24, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29132855/willingness-to-pay-and-quality-of-life-in-alopecia-areata
#17
Jean-Phillip Okhovat, Tristan Grogan, Lewei Duan, Carolyn Goh
No abstract text is available yet for this article.
December 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29131041/skin-manifestations-of-targeted-antineoplastic-therapy
#18
Onofre Sanmartín
The management of oncology patients has changed significantly over recent years, with the development of new targeted anticancer therapies. Cutaneous adverse effects are among the most frequently observed toxicities with many targeted agents; their intensity can be dose-limiting or lead to the discontinuation of therapy. Tyrosine kinase inhibitors can cause maculopapular rash and hand-foot reaction, whereas papulopustular rash, paronychia, regulatory changes in hair, and dryness are caused by epidermal growth factor receptor inhibitors...
2018: Current Problems in Dermatology
https://www.readbyqxmd.com/read/29130636/efficacy-of-subcutaneous-injection-of-platelet-rich-plasma-in-alopecia-a-clinical-and-histological-pilot-study-on-a-rat-model-with-a-six-month-long-term-follow-up-experience
#19
Sophie Orliac, Jean-Michel Serfaty, Anne Perozziello, Olivier Zurlinden, Liliane Louedec, Benjamin Dallaudière
PURPOSE: To assess the potential of platelet-rich plasma (PRP) subcutaneous injection of to treat alopecia and to evaluate local toxicity. MATERIALS-METHODS: Twelve Hairless rats were used. At D0, we performed systematic clinical examination and divided the rat back into four quadrants (Q). We initiated subcutaneous injection using either PRP in PRPQ+, platelet-poor plasma (PPP) in PPPQ+, physiological serum (PS) in PSQ+, or no treatment (Q4). At D7, D14, D21, and D28 but also second month (M2), M3, M4, M5, rats had exactly the same injection procedure...
November 11, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29129979/hair-germ-model-in-vitro-via-human-postnatal-keratinocyte-dermal-papilla-interactions-impact-of-hyaluronic-acid
#20
Ekaterina Kalabusheva, Vasily Terskikh, Ekaterina Vorotelyak
Hair follicle (HF) reconstruction in vitro is a promising field in alopecia treatment and human HF development research. Here, we combined postnatal human dermal papilla (DP) cells and skin epidermal keratinocytes (KCs) in a hanging drop culture to develop an artificial HF germ. The method is based on DP cell hair-inducing properties and KC self-organization. We evaluated two protocols of aggregate assembling. Mixed HF germ-like structures demonstrated the initiation of epithelial-mesenchymal interaction, including WNT pathway activation and expression of follicular markers...
2017: Stem Cells International
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