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https://www.readbyqxmd.com/read/28092258/-frontal-fibrosing-alopecia-case-series-and-literature-review
#1
Fátima Tinoco-Fragoso, Judith Domínguez-Cherit, Silvia Méndez-Flores
Frontal fibrosing alopecia is a disease characterized by a symmetric and progressive loss of hair in the fronto-temporal and fronto-parietal lines that generally affects postmenopausal women. It is considered a variant of lichen planus pilaris for its clinical and histopathological features; although, its etiopathology is still unknown. In this report, we analyzed 4 cases of this disease and we discussed its clinical and histopathological characteristics, as well as their course after initiating treatment.
January 2017: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/28091407/clinical-characteristics-of-patients-with-drug-induced-liver-injury
#2
Li-Xia Yang, Cheng-Yuan Liu, Lun-Li Zhang, Ling-Ling Lai, Ming Fang, Chong Zhang
BACKGROUND: Drug is an important cause of liver injury and accounts for up to 40% of instances of fulminant hepatic failure. Drug-induced liver injury (DILI) is increasing while the diagnosis becomes more difficult. Though many drugs may cause DILI, Chinese herbal medicines have recently emerged as a major cause due to their extensive use in China. We aimed to provide drug safety information to patients and health carers by analyzing the clinical and pathological characteristics of the DILI and the associated drug types...
2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28088992/prevalence-of-hormonal-and-endocrine-dysfunction-in-patients-with-lichen-planopilaris-lpp-a-retrospective-data-analysis-of-168-patients
#3
Geraldine Cheyana Ranasinghe, Melissa P Piliang, Wilma F Bergfeld
BACKGROUND: Studies on the pathophysiology and comorbidities associated with lichen planopilaris (LPP) and frontal fibrosing alopecia (FFA) are limited. OBJECTIVE: The purpose of this study was to determine the prevalence of androgen excess in the postmenopausal LPP population, in relation to demographics and comorbidities. METHODS: A retrospective data analysis of 413 patients with LPP, FFA, and LPP/FFA seen in the Department of Dermatology at the Cleveland Clinic Foundation in Ohio between 2005 and 2015 was conducted...
February 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28088907/tofacitinib-an-oral-janus-kinase-inhibitor-perspectives-in-dermatology
#4
Kresimir Kostovic, Sandra Jerkovic Gulin, Zrinka Bukvic Mokos, Romana Ceovic
BACKGROUND: Tofacitinib (formerly known as CP-690,550, CP690550, tasocitinib), a novel selective immunosuppressant, is a small molecule classified as Janus kinase inhibitor. The aim of this review article is to present updated data summary on the tofacitinib in the field of dermatology. METHOD: We undertook a structured search of bibliographic databases for peer-reviewed scientific articles, including review articles, original research articles as well as case report articles based on inclusion/exclusion criteria...
January 12, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28077132/foxn1-deficient-nude-severe-combined-immunodeficiency
#5
REVIEW
Ioanna A Rota, Fatima Dhalla
Nude severe combined immunodeficiency is a rare inherited disease caused by autosomal recessive loss-of-function mutations in FOXN1. This gene encodes a transcription factor essential for the development of the thymus, the primary lymphoid organ that supports T-cell development and selection. To date nine cases have been reported presenting with the clinical triad of absent thymus resulting in severe T-cell immunodeficiency, congenital alopecia universalis and nail dystrophy. Diagnosis relies on testing for FOXN1 mutations, which allows genetic counselling and guides therapeutic management...
January 11, 2017: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/28076469/scoring-clinical-signs-can-help-diagnose-canine-visceral-leishmaniasis-in-a-highly-endemic-area-in-brazil
#6
Kleverton Ribeiro da Silva, Vitor Rosa Ramos de Mendonça, Kellen Matuzzy Silva, Leopoldo Fabrício Marçal do Nascimento, Antonio Ferreira Mendes-Sousa, Flaviane Alves de Pinho, Manoel Barral-Netto, Aldina Maria Prado Barral, Maria do Socorro Pires E Cruz
Canine visceral leishmaniasis (CVL) diagnosis is still a challenge in endemic areas with limited diagnostic resources. This study proposes a score with the potential to distinguish positive CVL cases from negative ones. We studied 265 dogs that tested positive for CVL on ELISA and parasitological tests. A score ranging between 0 and 19 was recorded on the basis of clinical signs. Dogs with CVL had an overall higher positivity of the majority of clinical signs than did dogs without CVL or with ehrlichiosis. Clinical signs such as enlarged lymph nodes (83...
January 1, 2017: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/28074525/efficacy-of-superficial-cryotherapy-on-the-eyebrows-of-patients-with-alopecia-universalis-also-treated-with-contact-immunotherapy-on-the-scalp-a-prospective-split-face-comparative-study
#7
Sung Jay Choe, Won-Soo Lee
BACKGROUND: Few treatment modalities are available for treating alopecia areata (AA) of the eyebrow. Due to the anatomical proximity of the eyebrows to the eyes, safety issues and side effects should always be taken into consideration when choosing the treatment modality. This study was designed to examine the efficacy of superficial cryotherapy on patients with AA of the eyebrow. METHODS: Superficial cryotherapy was performed every other week on the right eyebrow (SC-treated) in a total of 20 patients who had been previously treated with diphenylcyclopropenone (DPCP) immunotherapy on the scalp...
February 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28074524/trichoscopic-clues-for-diagnosis-of-alopecia-areata-and-trichotillomania-in-asians
#8
Saranya Khunkhet, Vasanop Vachiramon, Poonkiat Suchonwanit
BACKGROUND: Trichoscopy has become a useful diagnostic tool for various hair and scalp diseases, including alopecia areata (AA) and trichotillomania (TTM), which are sometimes difficult to distinguish clinically. OBJECTIVES: To describe trichoscopic findings of AA and TTM in an Asian population and to establish diagnostic clues for these conditions. METHODS: Trichoscopy was performed with a handheld dermoscope in 52 patients diagnosed with AA and 23 patients diagnosed with TTM...
February 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28073840/fda-approval-summary-sonidegib-for-locally-advanced-basal-cell-carcinoma
#9
Denise Casey, Suzanne Demko, Stacy Shord, Hong Zhao, Huanyu Chen, Kun He, Alexander Putman, Whitney S Helms, Patricia Keegan, Richard Pazdur
On July 24, 2015, the U. S. Food and Drug Administration (FDA) approved sonidegib (ODOMZO®, Novartis) for treatment of patients with locally advanced basal cell carcinoma (laBCC) not amenable to curative surgery or radiation therapy. The approval was based on data from one randomized, double-blind, non-comparative trial of two doses of sonidegib administered to 230 hedgehog inhibitor-naïve patients with metastatic basal cell carcinoma (mBCC, n=36) or laBCC (n=194). Patients were randomized 2:1 to receive sonidegib 800 mg (n=151) or 200 mg (n=79) daily...
January 10, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28070801/a-comparison-of-sexual-function-in-women-with-polycystic-ovary-syndrome-pcos-whose-mothers-had-pcos-during-their-pregnancy-period-with-those-without-pcos
#10
Mahsa Noroozzadeh, Fahimeh Ramezani Tehrani, Mahnaz Bahri Khomami, Fereidoun Azizi
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women during reproductive ages. Clinical symptoms associated with PCOS, such as hirsutism, acne, alopecia, obesity, and infertility, may lead to emotional morbidity and then impaired sexual function in those affected. During intrauterine development, the fetus may program the development of diseases during adulthood. In this study, we aimed to examine sexual function in women with PCOS, exposed to maternal androgen excess during their prenatal life compared to non-exposed PCOS patients...
January 9, 2017: Archives of Sexual Behavior
https://www.readbyqxmd.com/read/28065683/cutaneous-features-of-myotonic-dystrophy-types-1-and-2-implication-of-premature-aging-and-vitamin-d-homeostasis
#11
Elena Campione, Annalisa Botta, Monia Di Prete, Emanuele Rastelli, Manuela Gibellini, Antonio Petrucci, Sergio Bernardini, Giuseppe Novelli, Luca Bianchi, Augusto Orlandi, Roberto Massa, Chiara Terracciano
Skin changes have been described in myotonic dystrophy type 1 (DM1). However, whether and in which way skin is a target of specific disease alterations in DM1 and DM2 has not been yet clarified. This study aims to explore cutaneous features of DM1 and DM2 patients. Skin examination was performed in 60 DM1, 15 DM2, and 103 control, unselected patients by means of dermoscopy. It revealed quantitative and qualitative abnormalities of nevi and typical signs of premature aging in both DM1 and DM2 patients, with a significantly higher frequency of dysplastic nevi, alopecia, xerosis and seborrheic dermatitis...
November 16, 2016: Neuromuscular Disorders: NMD
https://www.readbyqxmd.com/read/28061966/new-treatments-for-hair-loss
#12
S Vañó-Galván, F Camacho
The treatment of hair loss is an important part of clinical dermatology given the prevalence of the problem and great impact on patients' quality of life. Many new treatments have been introduced in recent years. This review summarizes the main ones in 4 groups: a) For androgenetic alopecia, we discuss new excipients for oral minoxidil, dutasteride, and finasteride as well as new forms of topical application; prostaglandin agonists and antagonists; low-level laser therapy; and regenerative medicine with Wnt signaling activators and stem cell therapy...
January 3, 2017: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/28060687/adult-acne-prevalence-and-portrayal-in-primary-healthcare-patients-in-the-greater-porto-area-portugal
#13
Diogo Semedo, Filipa Ladeiro, Mariana Ruivo, Carlos D'Oliveira, Filipa De Sousa, Mariana Gayo, Clara Lima, Frederico Magalhães, Rui Brandão, Maria Branco, Isabel Da Silva, Joana Batista, João Amado, António Massa, João Neves-Amado
INTRODUCTION: Though typically found in adolescents, acne frequently affects the adult population. In Portugal, no representative studies about acne prevalence in greater populational areas are known. This study had the following objectives: calculate acne prevalence in primary healthcare patients; its characteristics, including risk factors for onset and worsening; collect information concerning selfmedication and/or prescribed treatment. MATERIAL AND METHODS: Application of a questionnaire and physical examination into a convenience sample, composed by adults from20 - 60 years old that visited, in random days, five primary healthcare centers of the Greater Porto area...
September 2016: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/28056966/pseudorabies-virus-infection-aujeszky-s-disease-in-an-iberian-lynx-lynx-pardinus-in-spain-a-case-report
#14
A Javier Masot, María Gil, David Risco, Olga M Jiménez, José I Núñez, Eloy Redondo
BACKGROUND: The only natural hosts of Pseudorabies virus (PRV) are members of the family Suidae (Sus scrofa scrofa). In species other than suids infection is normally fatal. In these mammals, including carnivores, PRV typically causes serious neurologic disease. The endangered Iberian lynx (Lynx pardinus) is a wild feline endemic to south-western Europe (Iberian Peninsula). The Iberian lynx was found to be the world's most endangered felid species in 2002. In wild felines, PRV infection has only been previously reported once in a Florida panther in 1994...
January 5, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28056117/alopecia-following-bicoronal-incisions
#15
Sameep Kadakia, Arvind Badhey, Sara Ashai, Thomas S Lee, Yadranko Ducic
Importance: Multiple techniques may be used to perform bicoronal incisions, and alopecia is a known postoperative complication of this procedure. To date, no large studies exist comparing alopecia outcomes among bicoronal incision techniques with and without the use of Raney clips. Objective: To determine (1) whether postoperative alopecia is more common when bicoronal incisions are performed with monopolar cautery, Colorado microdissection tip cautery, or traditional cold steel and (2) whether this outcome is affected by the use of Raney clips...
January 5, 2017: JAMA Facial Plastic Surgery
https://www.readbyqxmd.com/read/28055072/diversity-in-dermatology-clinical-trials-a-systematic-review
#16
Alexandra Charrow, Fan Di Xia, Cara Joyce, Arash Mostaghimi
Importance: Though there have been significant shifts in US demographic data over the past 50 years, research cohorts lack full racial and ethnic representation. There is little data available regarding the diversity of dermatology research cohorts with respect to sex, race, and ethnicity. Objective: To characterize and assess the representation of racial and ethnic minorities and women in randomized controlled trials across a range of dermatologic conditions. Evidence Review: All randomized clinical trials (RCTs) were identified between July 2010 and July 2015 within the PubMed database using the following keywords: "psoriasis," "atopic dermatitis," "acne," "vitiligo," "seborrheic dermatitis," "alopecia areata," and "lichen planus...
January 4, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28054173/association-of-ahsg-with-alopecia-and-mental-retardation-apmr-syndrome
#17
M Reza Sailani, Fereshteh Jahanbani, Jafar Nasiri, Mahdiyeh Behnam, Mansoor Salehi, Maryam Sedghi, Majid Hoseinzadeh, Shinichi Takahashi, Amin Zia, Joshua Gruber, Janet Linnea Lynch, Daniel Lam, Juliane Winkelmann, Semira Amirkiai, Baoxu Pang, Shannon Rego, Safoura Mazroui, Jonathan A Bernstein, Michael P Snyder
Alopecia with mental retardation syndrome (APMR) is a very rare autosomal recessive condition that is associated with total or partial absence of hair from the scalp and other parts of the body as well as variable intellectual disability. Here we present whole-exome sequencing results of a large consanguineous family segregating APMR syndrome with seven affected family members. Our study revealed a novel predicted pathogenic, homozygous missense mutation in the AHSG (OMIM 138680) gene (AHSG: NM_001622:exon7:c...
January 4, 2017: Human Genetics
https://www.readbyqxmd.com/read/28050147/sensor-controlled-scalp-cooling-to-prevent-chemotherapy-induced-alopecia-in-female-cancer-patients
#18
M K Fehr, J Welter, W Sell, R Jung, R Felberbaum
BACKGROUND: Scalp cooling has been used since the 1970s to prevent chemotherapy-induced alopecia, one of the most common and psychologically troubling side effects of chemotherapy. Currently available scalp cooling systems demonstrate varying results in terms of effectiveness and tolerability. METHODS: For the present prospective study, 55 women receiving neoadjuvant, adjuvant, or palliative chemotherapy were enrolled. The aim was to assess the effectiveness of a sensor-controlled scalp cooling system (DigniCap: Sysmex Europe GmbH, Norderstedt, Germany) to prevent chemotherapy-induced alopecia in breast or gynecologic cancer patients receiving 1 of 7 regimens...
December 2016: Current Oncology
https://www.readbyqxmd.com/read/28046677/su-f-t-218-validation-of-an-in-vivo-proton-range-verification-method-for-reducing-the-risk-of-permanent-alopecia-in-the-treatment-of-pediatric-medulloblastoma
#19
G Lucconi, E Bentefour, S Deepak, G Janssens, K Weaver, M Moteabbed, H-M Lu
PURPOSE: The clinical commissioning of a workflow for pre-treatment range verification/adjustment for the head treatment of pediatric medulloblastoma patients, including dose monitoring during treatment. METHODS: An array of Si-diodes (DIODES Incorporated) is placed on the patient skin on the opposite side to the beam entrance. A "scout" SOBP beam, with a longer beam range to cover the diodes in its plateau, is delivered; the measured signal is analyzed and the extracted water equivalent path lengths (WEPL) are compared to the expected values, revealing if a range correction is needed...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28044367/bilateral-half-head-comparison-of-1-anthralin-ointment-in-children-with-alopecia-areata
#20
Mustafa Özdemir, Ali Balevi
BACKGROUND/OBJECTIVES: Alopecia areata (AA) is one of the most difficult skin diseases to manage well. In children, anthralin is commonly used for the treatment of AA. Available research consists of a limited number of uncontrolled trials that assessed the effectiveness of anthralin in promoting hair growth in patients with AA. The objective of this study was to validate the clinical effectiveness of short-contact anthralin 1% ointment in children with AA. METHODS: Thirty children with chronic, severe, treatment-refractory, extensive AA were treated with 1% anthralin ointment...
January 3, 2017: Pediatric Dermatology
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