Line Pourtau, Fabien Wauquier, Line Boutin-Wittrant, David Gaudout, Benjamin Moras, Adeline Vignault, Carole Vaysse, Tristan Richard, Arnaud Courtois, Stéphanie Krisa, Véronique Roux, Nicolas Macian, Gisèle Pickering, Yohann Wittrant
Safe and anti-inflammatory plant-based natural products present an increasing focus in the treatment of chronic inflammatory diseases such as osteoarthritis or inflammatory bowel diseases. Among them, saffron, a spice derived from the stigma of Crocus sativus, could have anti-inflammatory properties and would be therefore a promising therapeutic agent for the treatment of such conditions. However, the anti-inflammatory molecular mechanisms of saffron in humans are still understudied and unclear. In this study, combining human serum metabolites and cell cultures, we evaluated the effect of circulating metabolites from the consumption of a patented saffron extract (Safr'InsideTM ) on the chondrocytes and colon epithelial cell responses to inflammatory stress...
February 28, 2024: Pharmaceutics