Patricia K Riggs, Albert M Anderson, Bin Tang, Leah H Rubin, Susan Morgello, Christina M Marra, Benjamin B Gelman, David B Clifford, Donald Franklin, Robert K Heaton, Ronald J Ellis, Christine Fennema-Notestine, Scott L Letendre
Structural brain abnormalities, including those in white matter (WM), remain common in people with HIV (PWH). Their pathogenesis is uncertain and may reflect multiple etiologies. Oxidative stress is associated with inflammation, HIV, and its comorbidities. The post-translational carbonylation of proteins results from oxidative stress, and circulating protein carbonyls may reflect this. In this cross-sectional analysis, we evaluated the associations between protein carbonyls and a panel of soluble biomarkers of neuronal injury and inflammation in plasma (N = 45) and cerebrospinal fluid (CSF, n = 32) with structural brain MRI...
December 12, 2023: Viruses