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David A Rubin

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https://www.readbyqxmd.com/read/29351995/enucleated-cells-reveal-differential-roles-of-the-nucleus-in-cell-migration-polarity-and-mechanotransduction
#1
David M Graham, Tomas Andersen, Lisa Sharek, Gunes Uzer, Katheryn Rothenberg, Brenton D Hoffman, Janet Rubin, Martial Balland, James E Bear, Keith Burridge
The nucleus has long been postulated to play a critical physical role during cell polarization and migration, but that role has not been defined or rigorously tested. Here, we enucleated cells to test the physical necessity of the nucleus during cell polarization and directed migration. Using enucleated mammalian cells (cytoplasts), we found that polarity establishment and cell migration in one dimension (1D) and two dimensions (2D) occur without the nucleus. Cytoplasts directionally migrate toward soluble (chemotaxis) and surface-bound (haptotaxis) extracellular cues and migrate collectively in scratch-wound assays...
January 19, 2018: Journal of Cell Biology
https://www.readbyqxmd.com/read/29332038/sex-influences-the-accuracy-of-subjective-memory-complaint-reporting-in-older-adults
#2
Erin E Sundermann, Emily C Edmonds, Lisa Delano-Wood, Douglas R Galasko, David P Salmon, Leah H Rubin, Mark W Bondi
Subjective memory complaints (SMC) are required when diagnosing amnestic mild cognitive impairment (aMCI), although their relationship with objective memory performance and Alzheimer's disease (AD) pathology remains unclear. We investigated whether the sex of the patient/participant moderates these associations. Participants were 940 normal control (NC) and aMCI participants from the Alzheimer's Disease Neuroimaging Initiative. SMC were assessed via the memory scale of the Everyday Cognition questionnaire. Discrepancy scores were calculated between self- and informant-reports and categorized into "overestimates," "comparable estimates", and "underestimates" of SMC...
2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29309564/role-of-syncope-in-predicting-adverse-outcomes-in-patients-with-suspected-brugada-syndrome-undergoing-standardized-flecainide-testing
#3
Juan Pablo Flórez, Daniel García, Irene Valverde, José Rubín, Diego Pérez, Mar González-Vasserot, Julián Reguero, Jesús María de la Hera, Pablo Avanzas, Juan Gómez, Eliecer Coto, César Morís, David Calvo
Aims: Sensitivity to flecainide testing results in suboptimal findings in patients with Brugada syndrome (BrS), leading to safety concerns. Because cardiac syncope effectively predicts outcomes in BrS, we aimed to explore its predictive value in a large cohort of negative and positive responders (NR and PR) to standard flecainide testing. Methods and results : We analysed the data of 251 consecutive patients, 177 NR vs. 74 PR, to flecainide testing, performed according to standard recommendations...
December 22, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29300867/delta-of-the-local-ventriculo-atrial-intervals-at-the-septal-location-to-differentiate-tachycardia-using-septal-accessory-pathways-from-atypical-atrioventricular-nodal-re-entry
#4
David Calvo, Diego Pérez, José Rubín, Daniel García, Pablo Ávila, F Javier García-Fernández, Marta Pachón, Loreto Bravo, Jesús Hernández, Ángel L Miracle, Irene Valverde, Mar Gozalez-Vasserot, Miguel Ángel Árias, Javier Jimenez-Candíl, César Morís
Aims: Tachycardia mediated by septal accessory pathways (AP) and atypical atrioventricular nodal re-entry (AVNRT) require careful electrophysiologic evaluation for differential diagnosis. We aim to describe the differential behaviour of local ventriculo-atrial (VA) intervals which predicts the tachycardia mechanism. Methods and results: The local VA intervals at the para-Hisian septum were measured under three different situations: (i) tachycardia; (ii) sustained entrainment from the right ventricular apex (RVA); and (iii) continuous pacing from the RVA during sinus rhythm...
January 2, 2018: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29290338/genotype-phenotype-correlation-in-nf1-evidence-for-a-more-severe-phenotype-associated-with-missense-mutations-affecting-nf1-codons-844-848
#5
Magdalena Koczkowska, Yunjia Chen, Tom Callens, Alicia Gomes, Angela Sharp, Sherrell Johnson, Meng-Chang Hsiao, Zhenbin Chen, Meena Balasubramanian, Christopher P Barnett, Troy A Becker, Shay Ben-Shachar, Debora R Bertola, Jaishri O Blakeley, Emma M M Burkitt-Wright, Alison Callaway, Melissa Crenshaw, Karin S Cunha, Mitch Cunningham, Maria D D'Agostino, Karin Dahan, Alessandro De Luca, Anne Destrée, Radhika Dhamija, Marica Eoli, D Gareth R Evans, Patricia Galvin-Parton, Jaya K George-Abraham, Karen W Gripp, Jose Guevara-Campos, Neil A Hanchard, Concepcion Hernández-Chico, LaDonna Immken, Sandra Janssens, Kristi J Jones, Beth A Keena, Aaina Kochhar, Jan Liebelt, Arelis Martir-Negron, Maurice J Mahoney, Isabelle Maystadt, Carey McDougall, Meriel McEntagart, Nancy Mendelsohn, David T Miller, Geert Mortier, Jenny Morton, John Pappas, Scott R Plotkin, Dinel Pond, Kenneth Rosenbaum, Karol Rubin, Laura Russell, Lane S Rutledge, Veronica Saletti, Rhonda Schonberg, Allison Schreiber, Meredith Seidel, Elizabeth Siqveland, David W Stockton, Eva Trevisson, Nicole J Ullrich, Meena Upadhyaya, Rick van Minkelen, Helene Verhelst, Margaret R Wallace, Yoon-Sim Yap, Elaine Zackai, Jonathan Zonana, Vickie Zurcher, Kathleen Claes, Yolanda Martin, Bruce R Korf, Eric Legius, Ludwine M Messiaen
Neurofibromatosis type 1 (NF1), a common genetic disorder with a birth incidence of 1:2,000-3,000, is characterized by a highly variable clinical presentation. To date, only two clinically relevant intragenic genotype-phenotype correlations have been reported for NF1 missense mutations affecting p.Arg1809 and a single amino acid deletion p.Met922del. Both variants predispose to a distinct mild NF1 phenotype with neither externally visible cutaneous/plexiform neurofibromas nor other tumors. Here, we report 162 individuals (129 unrelated probands and 33 affected relatives) heterozygous for a constitutional missense mutation affecting one of five neighboring NF1 codons-Leu844, Cys845, Ala846, Leu847, and Gly848-located in the cysteine-serine-rich domain (CSRD)...
January 4, 2018: American Journal of Human Genetics
https://www.readbyqxmd.com/read/29286980/multiple-hybrid-cysts-in-a-child-challenge
#6
James Abbott, Mark C Mochel, Tricia Bhatti, David Low, Adam I Rubin
No abstract text is available yet for this article.
January 2018: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29286977/multiple-hybrid-cysts-in-a-child-answer
#7
James Abbott, Mark C Mochel, Tricia Bhatti, David Low, Adam I Rubin
No abstract text is available yet for this article.
January 2018: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29281590/quantification-of-5-ht1a-and-5-ht2a-receptor-binding-in-depressed-suicide-attempters-and-non-attempters
#8
J John Mann, Allison V Metts, R Todd Ogden, Chester A Mathis, Harry Rubin-Falcone, Zhiqun Gong, Wayne C Drevets, Jamie Zelazny, David A Brent
No abstract text is available yet for this article.
December 27, 2017: Archives of Suicide Research: Official Journal of the International Academy for Suicide Research
https://www.readbyqxmd.com/read/29234490/geminin-deficiency-enhances-survival-in-a-murine-medulloblastoma-model-by-inducing-apoptosis-of-preneoplastic-granule-neuron-precursors
#9
Savita Sankar, Ethan Patterson, Emily M Lewis, Laura E Waller, Caili Tong, Joshua Dearborn, David Wozniak, Joshua B Rubin, Kristen L Kroll
Medulloblastoma is the most common malignant brain cancer of childhood. Further understanding of tumorigenic mechanisms may define new therapeutic targets. Geminin maintains genome fidelity by controlling re-initiation of DNA replication within a cell cycle. In some contexts, Geminin inhibition induces cancer-selective cell cycle arrest and apoptosis and/or sensitizes cancer cells to Topoisomerase IIα inhibitors such as etoposide, which is used in combination chemotherapies for medulloblastoma. However, Geminin's potential role in medulloblastoma tumorigenesis remained undefined...
September 2017: Genes & Cancer
https://www.readbyqxmd.com/read/29191969/olaratumab-exerts-anti-tumor-activity-in-preclinical-models-of-pediatric-bone-and-soft-tissue-tumors-through-inhibition-of-platelet-derived-growth-factor-receptor-alpha
#10
Caitlin D Lowery, Wayne Blosser, Michele Dowless, Shelby Knoche, Jennifer Stephens, Huiling Li, David Surguladze, Nick Loizos, Debra Luffer-Atlas, Gerard Joseph Oakley, Qianxu Guo, Seema Iyer, Brian P Rubin, Louis F Stancato
PURPOSE: Platelet-derived growth factor receptor alpha (PDGFRα) is implicated in several adult and pediatric malignancies, where activated signaling in tumor cells and/or cells within the microenvironment drive tumorigenesis and disease progression. Olaratumab (LY3012207/IMC-3G3) is a human monoclonal antibody that exclusively binds to PDGFRα and recently received accelerated FDA approval and conditional EMA approval for treatment of advanced adult sarcoma patients in combination with doxorubicin...
November 30, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29156364/pattern-recognition-of-magnetic-resonance-imaging-based-gray-matter-volume-measurements-classifies-bipolar-disorder-and-major-depressive-disorder
#11
Harry Rubin-Falcone, Francesca Zanderigo, Binod Thapa-Chhetry, Martin Lan, Jeffrey M Miller, M Elizabeth Sublette, Maria A Oquendo, David J Hellerstein, Patrick J McGrath, Johnathan W Stewart, J John Mann
BACKGROUND: Bipolar Disorder (BD) cannot be reliably distinguished from Major Depressive Disorder (MDD) until the first manic or hypomanic episode. Consequently, many patients with BD are treated with antidepressants without mood stabilizers, a strategy that is often ineffective and carries a risk of inducing a manic episode. We previously reported reduced cortical thickness in right precuneus, right caudal middle-frontal cortex and left inferior parietal cortex in BD compared with MDD...
November 13, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29132217/update-on-pulmonary-arterial-hypertension-research-proceedings-from-a-meeting-of-experts
#12
Vallerie McLaughlin, Matthew Bacchetta, David Badesch, Raymond Benza, Charles Burger, Kelly Chin, Robert Frantz, Adaani Frost, Anna Hemnes, Nick H Kim, Erika B Rosenzweig, Lewis Rubin
While pulmonary arterial hypertension (PAH) remains a progressive, symptomatic condition characterized by increased pulmonary vascular resistance, ultimately leading to right heart failure, great strides have been made in its understanding and treatment over the past two decades. Continued research in preclinical, clinical, and health economic areas of research, in addition to registry analyses and technology advances, is critical for understanding the pathophysiology of the disease and devising the best ways to monitor and manage patients...
November 13, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29110854/sorafenib-and-continued-erlotinib-or-sorafenib-alone-in-patients-with-advanced-non-small-cell-lung-cancer-progressing-on-erlotinib-a-randomized-phase-ii-study-of-the-sarah-cannon-research-institute-scri
#13
David R Spigel, Mark S Rubin, Victor G Gian, Dianna L Shipley, Howard A Burris, Rebecca A Kosloff, Kent C Shih, Raven Quinn, F Anthony Greco, John D Hainsworth
PURPOSE: To evaluate the efficacy of erlotinib, continued after tumor progression, plus sorafenib versus sorafenib alone in patients with refractory metastatic non-small cell lung cancer (NSCLC) who previously benefitted from single-agent erlotinib. PATIENTS AND METHODS: Patients with progressive refractory NSCLC who had previously benefitted from erlotinib (objective response or stable disease >8weeks) were randomized to receive treatment with either erlotinib and sorafenib (400mg orally twice daily) or sorafenib alone...
November 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/29067779/an-antibacterial-%C3%AE-lactone-kills-mycobacterium-tuberculosis-by-infiltrating-mycolic-acid-biosynthesis
#14
Johannes Lehmann, Tan-Yun Cheng, Anup Aggarwal, Annie S Park, Evelyn Zeiler, Ravikiran M Raju, Tatos Akopian, Olga Kandror, Nina C Bach, James C Sacchettini, David Branch Moody, Eric J Rubin, Stephan Axel Sieber
The spread of antibiotic resistance is a major challenge for treatment of Mycobacterium tuberculosis infection. In addition, efficacy of drugs is often limited by the restricted permeability of the mycomembrane. Frontline antibiotics inhibit mycomembrane biosynthesis leading to rapid cell death. Inspired by this mechanism we exploit β-lactones as putative mycolic acid mimics to block serine hydrolases involved in their biosynthesis. Among a collection of β-lactones we found one hit with potent anti-mycobacterial and bactericidal activity...
October 24, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/29066554/cortical-regulation-of-nociception-of-the-trigeminal-nucleus-caudalis
#15
Alberto Castro, Charles Raver, Ying Li, Olivia Uddin, David Rubin, Yadong Ji, Radi Masri, Asaf Keller
Pain perception is strongly influenced by descending pathways from "higher" brain centers that regulate the activity of spinal circuits. In addition to the extensively studied descending system originating from the medulla, the neocortex provides dense anatomical projections that directly target neurons in the spinal cord and the spinal trigeminal nucleus caudalis (SpVc). Evidence exists that these corticotrigeminal pathways may modulate the processing of nociceptive inputs by SpVc, and regulate pain perception...
October 24, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29028947/dlx1-and-dlx2-promote-interneuron-gaba-synthesis-synaptogenesis-and-dendritogenesis
#16
Ramon Pla, Amelia Stanco, MacKenzie A Howard, Anna N Rubin, Daniel Vogt, Niall Mortimer, Inma Cobos, Gregory Brian Potter, Susan Lindtner, James D Price, Alex S Nord, Axel Visel, Christoph E Schreiner, Scott C Baraban, David H Rowitch, John L R Rubenstein
The postnatal functions of the Dlx1&2 transcription factors in cortical interneurons (CINs) are unknown. Here, using conditional Dlx1, Dlx2, and Dlx1&2 knockouts (CKOs), we defined their roles in specific CINs. The CKOs had dendritic, synaptic, and survival defects, affecting even PV+ CINs. We provide evidence that DLX2 directly drives Gad1, Gad2, and Vgat expression, and show that mutants had reduced mIPSC amplitude. In addition, the mutants formed fewer GABAergic synapses on excitatory neurons and had reduced mIPSC frequency...
September 28, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/29019612/unveiling-transthyretin-cardiac-amyloidosis-and-its-predictors-among-elderly-patients-with-severe-aortic-stenosis-undergoing-transcatheter-aortic-valve-replacement
#17
Adam Castaño, David L Narotsky, Nadira Hamid, Omar K Khalique, Rachelle Morgenstern, Albert DeLuca, Jonah Rubin, Codruta Chiuzan, Tamim Nazif, Torsten Vahl, Isaac George, Susheel Kodali, Martin B Leon, Rebecca Hahn, Sabahat Bokhari, Mathew S Maurer
Aims: Transthyretin cardiac amyloidosis (ATTR-CA) has been reported in patients with aortic stenosis (AS) but its prevalence and phenotype are not known. We examine elderly patients with severe symptomatic AS undergoing transcatheter aortic valve replacement (TAVR) and determine the prevalence and phenotype of ATTR-CA non-invasively. Methods and results: We performed technetium-99m pyrophosphate (99mTc-PYP) cardiac scintigraphy prospectively on patients who underwent TAVR, to screen for ATTR-CA...
October 7, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28967888/critical-assessment-of-metagenome-interpretation-a-benchmark-of-metagenomics-software
#18
Alexander Sczyrba, Peter Hofmann, Peter Belmann, David Koslicki, Stefan Janssen, Johannes Dröge, Ivan Gregor, Stephan Majda, Jessika Fiedler, Eik Dahms, Andreas Bremges, Adrian Fritz, Ruben Garrido-Oter, Tue Sparholt Jørgensen, Nicole Shapiro, Philip D Blood, Alexey Gurevich, Yang Bai, Dmitrij Turaev, Matthew Z DeMaere, Rayan Chikhi, Niranjan Nagarajan, Christopher Quince, Fernando Meyer, Monika Balvočiūtė, Lars Hestbjerg Hansen, Søren J Sørensen, Burton K H Chia, Bertrand Denis, Jeff L Froula, Zhong Wang, Robert Egan, Dongwan Don Kang, Jeffrey J Cook, Charles Deltel, Michael Beckstette, Claire Lemaitre, Pierre Peterlongo, Guillaume Rizk, Dominique Lavenier, Yu-Wei Wu, Steven W Singer, Chirag Jain, Marc Strous, Heiner Klingenberg, Peter Meinicke, Michael D Barton, Thomas Lingner, Hsin-Hung Lin, Yu-Chieh Liao, Genivaldo Gueiros Z Silva, Daniel A Cuevas, Robert A Edwards, Surya Saha, Vitor C Piro, Bernhard Y Renard, Mihai Pop, Hans-Peter Klenk, Markus Göker, Nikos C Kyrpides, Tanja Woyke, Julia A Vorholt, Paul Schulze-Lefert, Edward M Rubin, Aaron E Darling, Thomas Rattei, Alice C McHardy
Methods for assembly, taxonomic profiling and binning are key to interpreting metagenome data, but a lack of consensus about benchmarking complicates performance assessment. The Critical Assessment of Metagenome Interpretation (CAMI) challenge has engaged the global developer community to benchmark their programs on highly complex and realistic data sets, generated from ∼700 newly sequenced microorganisms and ∼600 novel viruses and plasmids and representing common experimental setups. Assembly and genome binning programs performed well for species represented by individual genomes but were substantially affected by the presence of related strains...
November 2017: Nature Methods
https://www.readbyqxmd.com/read/28944321/effect-of-evacuation-and-displacement-on-the-association-between-flooding-and-mental-health-outcomes-a-cross-sectional-analysis-of-uk-survey-data
#19
Alice Munro, R Sari Kovats, G James Rubin, Thomas David Waite, Angie Bone, Ben Armstrong
BACKGROUND: Extensive flooding occurred during the winter of 2013-14 in England. Previous studies have shown that flooding affects mental health. Using data from the 2013-14 Public Health England National Study of Flooding and Health, we compared the prevalence of symptoms of depression, anxiety, and post-traumatic stress disorder between participants displaced by flooding and those flooded, but not displaced, 1 year after flooding. METHODS: In this multivariable ordinal regression analysis, we collected data from a cross-sectional survey collected 1 year after the flooding event from flood-affected postcodes in five counties in England...
July 2017: Lancet. Planetary Health
https://www.readbyqxmd.com/read/28942746/rapid-autopsy-of-a-patient-with-recurrent-anaplastic-ependymoma
#20
Katharine Rae Lange, Cheryl Fischer, Prajwal Rajappa, Scott Connors, David Pisapia, Jeffrey P Greenfield, Himisha Beltran, Mark Rubin, Juan Miguel Mosquera, Yasmin Khakoo
OBJECTIVE: Our aim was to outline a procedure for obtaining a rapid autopsy in order to collect high-quality postmortem tissue for genomic analysis. METHODS: This report details a bi-institutional collaborative effort to coordinate a rapid autopsy for a pediatric patient who had died at home. We discuss the scientific rationale for offering a rapid autopsy to caregivers of pediatric patients as well as parental perspectives on broaching the subject of autopsy. We then review the logistics and coordination involved with planning a rapid autopsy and the sequence of events needed to maximize tissue quality...
September 25, 2017: Palliative & Supportive Care
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