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David A Rubin

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https://www.readbyqxmd.com/read/28904086/cognitive-trajectories-over-4-years-among-hiv-infected-women-with-optimal-viral-suppression
#1
Leah H Rubin, Pauline M Maki, Gayle Springer, Lorie Benning, Kathryn Anastos, Deborah Gustafson, Maria C Villacres, Xiong Jiang, Adaora A Adimora, Drenna Waldrop-Valverde, David E Vance, Hector Bolivar, Christine Alden, Eileen M Martin, Victor G Valcour
OBJECTIVE: To determine whether persistent viral suppression alters cognitive trajectories among HIV-infected (HIV+) women on combination antiretroviral therapy (cART) by investigating performance longitudinally in uninfected (HIV-) and 3 groups of HIV+ women: those with consistent viral suppression after continuous cART use (VS), those without consistent virologic suppression despite continuous cART use (NVS), and those without consistent virologic suppression after intermittent cART use (Int NVS)...
September 13, 2017: Neurology
https://www.readbyqxmd.com/read/28903966/laser-in-glaucoma-and-ocular-hypertension-light-trial-a-multicentre-randomised-controlled-trial-design-and-methodology
#2
Gus Gazzard, Evgenia Konstantakopoulou, David Garway-Heath, Keith Barton, Richard Wormald, Stephen Morris, Rachael Hunter, Gary Rubin, Marta Buszewicz, Gareth Ambler, Catey Bunce
PURPOSE: The Laser in Glaucoma and Ocular Hypertension (LiGHT) Trial aims to establish whether initial treatment with selective laser trabeculoplasty (SLT) is superior to initial treatment with topical medication for primary open-angle glaucoma (POAG) or ocular hypertension (OHT). DESIGN: The LiGHT Trial is a prospective, unmasked, multicentre, pragmatic, randomised controlled trial. 718 previously untreated patients with POAG or OHT were recruited at six collaborating centres in the UK between 2012 and 2014...
September 13, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28893134/mepolizumab-for-eosinophilic-chronic-obstructive-pulmonary-disease
#3
Ian D Pavord, Pascal Chanez, Gerard J Criner, Huib A M Kerstjens, Stephanie Korn, Njira Lugogo, Jean-Benoit Martinot, Hironori Sagara, Frank C Albers, Eric S Bradford, Stephanie S Harris, Bhabita Mayer, David B Rubin, Steven W Yancey, Frank C Sciurba
Background Patients with chronic obstructive pulmonary disease (COPD) with an eosinophilic phenotype may benefit from treatment with mepolizumab, a monoclonal antibody directed against interleukin-5. Methods We performed two phase 3, randomized, placebo-controlled, double-blind, parallel-group trials comparing mepolizumab (100 mg in METREX, 100 or 300 mg in METREO) with placebo, given as a subcutaneous injection every 4 weeks for 52 weeks in patients with COPD who had a history of moderate or severe exacerbations while taking inhaled glucocorticoid-based triple maintenance therapy...
September 11, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28885950/family-characteristics-associated-with-child-maltreatment-across-the-deployment-cycle-of-u-s-army-soldiers
#4
Douglas Strane, Kevin G Lynch, Heather M Griffis, Christine M Taylor, Gerlinde C Harb, Lanyu Mi, Lihai Song, Benjamin French, David M Rubin
OBJECTIVE: Soldier deployment can create a stressful environment for U.S. Army families with young children. Prior research has identified elevated rates of child maltreatment in the 6 months immediately following a soldier's return home from deployment. In this study, we longitudinally examine how other child- and family-level characteristics influence the relationship of deployment to risk for maltreatment of dependent children of U.S. Army soldiers. METHODS: We conducted a person-time analysis of substantiated reports and medical diagnoses of maltreatment among the 73,404 children of 56,087 U...
September 2017: Military Medicine
https://www.readbyqxmd.com/read/28877995/a-neuroprotective-agent-that-inactivates-prodegenerative-trka-and-preserves-mitochondria
#5
Konstantin Feinberg, Adelaida Kolaj, Chen Wu, Natalie Grinshtein, Jonathan R Krieger, Michael F Moran, Lee L Rubin, Freda D Miller, David R Kaplan
Axon degeneration is an early event and pathological in neurodegenerative conditions and nerve injuries. To discover agents that suppress neuronal death and axonal degeneration, we performed drug screens on primary rodent neurons and identified the pan-kinase inhibitor foretinib, which potently rescued sympathetic, sensory, and motor wt and SOD1 mutant neurons from trophic factor withdrawal-induced degeneration. By using primary sympathetic neurons grown in mass cultures and Campenot chambers, we show that foretinib protected neurons by suppressing both known degenerative pathways and a new pathway involving unliganded TrkA and transcriptional regulation of the proapoptotic BH3 family members BimEL, Harakiri,and Puma, culminating in preservation of mitochondria in the degenerative setting...
September 6, 2017: Journal of Cell Biology
https://www.readbyqxmd.com/read/28870101/effects-of-non-medical-switching-on-outcomes-among-patients-prescribed-tumor-necrosis-factor-inhibitors
#6
Allan Gibofsky, Martha Skup, Manish Mittal, Scott J Johnson, Matthew Davis, Jingdong Chao, David T Rubin
OBJECTIVE: To evaluate health care use and outcomes among patients who experienced a non-medical switch of their prescribed anti-tumor necrosis factor biological agent (anti-TNF) for cost containment reasons. METHODS: Retrospective evaluation of Humedica electronic health records of patients ≥18 years old with anti-TNF treatment for immune conditions. Using natural language processing, stable patients who experienced a non-medical switch (for cost or insurance reasons) of their anti-TNF between 2007 and 2013 were identified (NMS cohort, n = 158) and matched to patients who did not (control cohort, n = 4804)...
September 5, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28865284/the-relationship-between-consumer-clinician-and-organizational-characteristics-and-use-of-evidence-based-and-non-evidence-based-therapy-strategies-in-a-public-mental-health-system
#7
Rinad Beidas, Laura Skriner, Danielle Adams, Courtney Benjamin Wolk, Rebecca E Stewart, Emily Becker-Haimes, Nathaniel Williams, Brenna Maddox, Ronnie Rubin, Shawna Weaver, Arthur Evans, David Mandell, Steven C Marcus
We investigated the relationship between consumer, clinician, and organizational factors and clinician use of therapy strategies within a system-wide effort to increase the use of cognitive-behavioral therapy. Data from 247 clinicians in 28 child-serving organizations were collected. Clinicians participating in evidence-based practice training initiatives were more likely to report using cognitive-behavioral therapy when they endorsed more clinical experience, being salaried clinicians, and more openness to evidence-based practice...
August 25, 2017: Behaviour Research and Therapy
https://www.readbyqxmd.com/read/28864460/a-germline-fanca-alteration-that-is-associated-with-increased-sensitivity-to-dna-damaging-agents
#8
David C Wilkes, Verena Sailer, Hui Xue, Hongwei Cheng, Colin C Collins, Martin Gleave, Yuzhuo Wang, Francesca Demichelis, Himisha Beltran, Mark A Rubin, David S Rickman
Defects in genes involved in DNA damage repair (DDR) pathway are emerging as novel biomarkers and targets for new prostate cancer drug therapies. A previous report revealed an association between an exceptional response to cisplatin treatment and a somatic loss of heterozygosity (LOH) of FANCA in a patient with metastatic prostate cancer who also harbored a germline FANCA variant (S1088F). Although germline FANCA mutations are the most frequent alterations in patients with Fanconi anemia, germline alterations are less common in prostate cancer...
September 2017: Cold Spring Harbor Molecular Case Studies
https://www.readbyqxmd.com/read/28858617/a-circuit-node-that-integrates-convergent-input-from-neuromodulatory-and-social-behavior-promoting-neurons-to-control-aggression-in-drosophila
#9
Kiichi Watanabe, Hui Chiu, Barret D Pfeiffer, Allan M Wong, Eric D Hoopfer, Gerald M Rubin, David J Anderson
Diffuse neuromodulatory systems such as norepinephrine (NE) control brain-wide states such as arousal, but whether they control complex social behaviors more specifically is not clear. Octopamine (OA), the insect homolog of NE, is known to promote both arousal and aggression. We have performed a systematic, unbiased screen to identify OA receptor-expressing neurons (OARNs) that control aggression in Drosophila. Our results uncover a tiny population of male-specific aSP2 neurons that mediate a specific influence of OA on aggression, independent of any effect on arousal...
August 30, 2017: Neuron
https://www.readbyqxmd.com/read/28856230/distribution-of-serum-concentrations-reported-for-macroenzyme-aspartate-aminotransferase-macro-ast
#10
Asa S Rubin, David A Sass, Douglas F Stickle
BACKGROUND: The presence of macroenzyme (M) is often the explanation of an isolated elevation of aspartate aminotransferase (AST). Where M is identified, it is reasonable for the clinician to ask where an individual patient's result fits in with known concentrations of M. In this context, we conducted a survey of literature to examine the distribution of reported serum concentrations of macro-AST. We also analyzed the distribution data to examine whether elevations were consistent with simple alteration of circulatory half-life (t1/2) of M relative to normal AST...
August 2017: Pract Lab Med
https://www.readbyqxmd.com/read/28846143/characterization-of-a-stepwise-approach-in-cavotricuspid-isthmus-ablation-for-typical-atrial-flutter-a-randomised-study-comparing-three-catheters
#11
José Manuel Rubín, David Calvo, Diego Pérez, Ana Fidalgo, Jesús María de la Hera, Lidia Martínez, Esmeralda Capín, Haritz Arrizabalaga, Lidia Carballeira, Daniel García, Cesar Morís
INTRODUCTION: Our aim was to characterize a stepwise approach in cavotricuspid isthmus ablation for typical atrial flutter in a prospective, non-crossover randomised study. METHODS: One hundred and fifty patients referred for cavotricuspid isthmus (CTI)-dependent atrial flutter ablation were randomised to undergo an ablation with an 8-mm-tip catheter (group 1), a 3.5-mm open irrigation tip catheter (group 2) and a 3.5-mm open irrigation porous-tip catheter (group 3)...
August 28, 2017: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/28837634/factors-associated-with-readmission-to-the-hospital-within-30-days-in-patients-with-inflammatory-bowel-disease
#12
Dejan Micic, John N Gaetano, Jonah N Rubin, Russell D Cohen, Atsushi Sakuraba, David T Rubin, Joel Pekow
BACKGROUND: Management of inpatients with inflammatory bowel disease (IBD) requires increasing resources. We aimed to identify factors associated with hospital readmissions among individuals with IBD. MATERIALS & METHODS: We collected data from the Healthcare Cost and Utilization Project Nationwide Readmissions Database 2013. We identified individuals with index hospitalizations for IBD. Patient-specific factors, comorbidities and hospitalization characteristics were extracted for the index hospitalization...
2017: PloS One
https://www.readbyqxmd.com/read/28833940/taking-tests-in-the-magnet-brain-mapping-standardized-tests
#13
David C Rubin, Dawei Li, Shana A Hall, Philip A Kragel, Dorthe Berntsen
Standardized psychometric tests are sophisticated, well-developed, and consequential instruments; test outcomes are taken as facts about people that impact their lives in important ways. As part of an initial demonstration that human brain mapping techniques can add converging neural-level evidence to understanding standardized tests, our participants completed items from standardized tests during an fMRI scan. We compared tests for diagnosing posttraumatic stress disorder (PTSD) and the correlated measures of Neuroticism, Attachment, and Centrality of Event to a general-knowledge baseline test...
August 18, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28810879/quantification-of-mutant-spop-proteins-in-prostate-cancer-using-mass-spectrometry-based-targeted-proteomics
#14
Hui Wang, Christopher E Barbieri, Jintang He, Yuqian Gao, Tujin Shi, Chaochao Wu, Athena A Schepmoes, Thomas L Fillmore, Sung-Suk Chae, Dennis Huang, Juan Miguel Mosquera, Wei-Jun Qian, Richard D Smith, Sudhir Srivastava, Jacob Kagan, David G Camp, Karin D Rodland, Mark A Rubin, Tao Liu
BACKGROUND: Speckle-type POZ protein (SPOP) is an E3 ubiquitin ligase adaptor protein that functions as a potential tumor suppressor, and SPOP mutations have been identified in ~10% of human prostate cancers. However, it remains unclear if mutant SPOP proteins can be utilized as biomarkers for early detection, diagnosis, prognosis or targeted therapy of prostate cancer. Moreover, the SPOP mutation sites are distributed in a relatively short region with multiple lysine residues, posing significant challenges for bottom-up proteomics analysis of the SPOP mutations...
August 15, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/28798178/draft-genome-sequence-of-mycobacterium-avium-11
#15
Michelle Yee, David Klinzing, Jun-Rong Wei, Martin Gengenbacher, Eric J Rubin, Jung-Yien Chien, Po-Ren Hsueh, Thomas Dick
Mycobacterium avium accounts for most lung disease caused by nontuberculous mycobacteria (NTM). The lack of effective chemotherapy calls for the discovery of new drugs. Here, we report the draft genome sequence of M. avium 11, a clinical isolate used as a screening strain for NTM-focused drug discovery.
August 10, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28798169/genome-sequences-of-mycobacteriophages-kerberos-pomar16-and-starstuff
#16
Deborah Jacobs-Sera, Oana Catinas, Mariceli Fernandez-Martinez, Amelia Garcia, Rebecca A Garlena, Carlos A Guerrero Bustamante, Michelle H Larsen, Rosa H Medellin, Martin Y Melendez-Ortiz, Crystal M Melendez-Rivera, Alondra K Mercado-Andino, Abner J Mercado-Delgado, Cathia P Ortiz-Ortiz, Ana M Quesada-Gordillo, Jacqueline M Ramos, Michael R Rubin, Daniel A Russell, Rachna A Sadana, Sanghamitra Saha, Edwin Vazquez, David Villarreal, Graham F Hatfull
We describe the genome sequences of three closely related mycobacteriophages, Kerberos, Pomar16, and StarStuff, isolated at similar times but from geographically distinct regions. All three genomes are similar to those of other subcluster A2 phages, such as L5 and D29, are temperate, and have siphoviral virion morphologies.
August 10, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28796415/white-matter-tract-integrity-is-associated-with-antidepressant-response-to-lurasidone-in-bipolar-depression
#17
Martin J Lan, Harry Rubin-Falcone, Fatima Motiwala, Ying Chen, Jonathan W Stewart, David J Hellerstein, J John Mann, Patrick J McGrath
OBJECTIVES: Patients with bipolar disorder spend the most time in the depressed phase, and that phase is associated with the most morbidity and mortality. Treatment of bipolar depression lacks a test to determine who will respond to treatment. White matter disruptions have been found in bipolar disorder. Previous reports suggest that white matter disruptions may be associated with resistance to antidepressant medication, but this has never been investigated in a prospective study using a Food and Drug Administration (FDA)-approved medication...
August 10, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28782026/buried-shallow-fault-slip-from-the-south-napa-earthquake-revealed-by-near-field-geodesy
#18
Benjamin A Brooks, Sarah E Minson, Craig L Glennie, Johanna M Nevitt, Tim Dawson, Ron Rubin, Todd L Ericksen, David Lockner, Kenneth Hudnut, Victoria Langenheim, Andrew Lutz, Maxime Mareschal, Jessica Murray, David Schwartz, Dana Zaccone
Earthquake-related fault slip in the upper hundreds of meters of Earth's surface has remained largely unstudied because of challenges measuring deformation in the near field of a fault rupture. We analyze centimeter-scale accuracy mobile laser scanning (MLS) data of deformed vine rows within ±300 m of the principal surface expression of the M (magnitude) 6.0 2014 South Napa earthquake. Rather than assuming surface displacement equivalence to fault slip, we invert the near-field data with a model that allows for, but does not require, the fault to be buried below the surface...
July 2017: Science Advances
https://www.readbyqxmd.com/read/28756053/patients-with-ulcerative-colitis-and-primary-sclerosing-cholangitis-frequently-have-subclinical-inflammation-in-the-proximal-colon
#19
Noa Krugliak Cleveland, David T Rubin, John Hart, Christopher R Weber, Katherine Meckel, Anthony L Tran, Arthur S Aelvoet, Isabella Pan, Alex Gonsalves, John Nick Gaetano, Kelli Williams, Kristen Wroblewski, Bana Jabri, Joel Pekow
BACKGROUND & AIMS: Patients with primary sclerosing cholangitis (PSC) and ulcerative colitis (UC) have a high risk of colonic neoplasia. Histologic inflammation is an independent risk factor for the development of neoplasia; we investigated whether patients with UC and PSC have more subclinical disease activity than patients with UC alone. METHODS: We performed a retrospective analysis of data from 143 patients (205 examinations) with ulcerative pancolitis who were in clinical remission and treated at a tertiary medical center from May 2011 through May 2016...
July 26, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28750683/identification-of-novel-prostate-cancer-drivers-using-regnetdriver-a-framework-for-integration-of-genetic-and-epigenetic-alterations-with-tissue-specific-regulatory-network
#20
Priyanka Dhingra, Alexander Martinez-Fundichely, Adeline Berger, Franklin W Huang, Andre Neil Forbes, Eric Minwei Liu, Deli Liu, Andrea Sboner, Pablo Tamayo, David S Rickman, Mark A Rubin, Ekta Khurana
We report a novel computational method, RegNetDriver, to identify tumorigenic drivers using the combined effects of coding and non-coding single nucleotide variants, structural variants, and DNA methylation changes in the DNase I hypersensitivity based regulatory network. Integration of multi-omics data from 521 prostate tumor samples indicated a stronger regulatory impact of structural variants, as they affect more transcription factor hubs in the tissue-specific network. Moreover, crosstalk between transcription factor hub expression modulated by structural variants and methylation levels likely leads to the differential expression of target genes...
July 27, 2017: Genome Biology
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