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David A Rubin

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https://www.readbyqxmd.com/read/29762344/use-of-nonantiretroviral-medications-that-may-impact-neurocognition-patterns-and-predictors-in-a-large-long-term-hiv-cohort-study
#1
Kendra K Radtke, Peter Bacchetti, Kathryn Anastos, Daniel Merenstein, Howard Crystal, Roksana Karim, Kathleen M Weber, Andrew Edmonds, Anandi N Sheth, Margaret A Fischl, David Vance, Ruth M Greenblatt, Leah H Rubin
BACKGROUND: Neurocognitive impairment is a frequent and often disabling comorbidity of HIV infection. In addition to antiretroviral therapies, individuals with HIV infection may commonly use nonantiretroviral medications that are known to cause neurocognitive adverse effects (NC-AE). The contribution of NC-AE to neurocognitive impairment is rarely considered in the context of HIV and could explain part of the variability in neurocognitive performance among individuals with HIV. SETTING: Women's Interagency HIV Study, a prospective, multisite, observational study of US women with and without HIV...
June 1, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29751166/safety-and-efficacy-of-combination-treatment-with-calcineurin-inhibitors-and-vedolizumab-in-patients-with-refractory-inflammatory-bowel-disease
#2
Britt Christensen, Peter Gibson, Dejan Micic, Ruben J Colman, Sarah R Goeppinger, Olufemmi Kassim, Andres Yarur, Christopher R Weber, Russell D Cohen, David T Rubin
BACKGROUND & AIMS: Little is known about the efficacy and safety of induction therapy with calcineurin inhibitors in combination with vedolizumab for patients with Crohn's disease (CD) or ulcerative colitis (UC). We analyzed the outcomes of patients receiving vedolizumab along with calcineurin inhibitors METHODS: We collected data on patients with CD (n=9) or UC (n=11) who began treatment with vedolizumab from May 20, 2014 through March 30, 2015 and received calcineurin inhibitors (tacrolimus or cyclosporin) during the first 12 months of vedolizumab therapy...
May 8, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29745356/noninfectious-hospital-adverse-events-decline-after-elimination-of-contact-precautions-for-mrsa-and-vre
#3
Elise M Martin, Brandy Bryant, Tristan R Grogan, Zachary A Rubin, Dana L Russell, David Elashoff, Daniel Z Uslan
OBJECTIVETo evaluate the impact of discontinuing routine contact precautions (CP) for endemic methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus (VRE) on hospital adverse events.DESIGNRetrospective, nonrandomized, observational, quasi-experimental study.SETTINGAcademic medical center with single-occupancy rooms.PARTICIPANTSInpatients.METHODSWe compared hospital reportable adverse events 1 year before and 1 year after discontinuation of routine CP for endemic MRSA and VRE (preintervention and postintervention periods, respectively)...
May 10, 2018: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/29741745/prospective-feasibility-and-safety-assessment-of-surgical-biopsy-for-patients-with-newly-diagnosed-diffuse-intrinsic-pontine-glioma
#4
Nalin Gupta, Liliana C Goumnerova, Peter Manley, Susan N Chi, Donna Neuberg, Maneka Puligandla, Jason Fangusaro, Stewart Goldman, Tadanori Tomita, Tord Alden, Arthur DiPatri, Joshua B Rubin, Karen Gauvain, David Limbrick, Jeffrey Leonard, J Russel Geyer, Sarah Leary, Samuel Browd, Zhihong Wang, Sandeep Sood, Anne Bendel, Mahmoud Nagib, Sharon Gardner, Matthias A Karajannis, David Harter, Kanyalakshmi Ayyanar, William Gump, Daniel C Bowers, Bradley Weprin, Tobey J MacDonald, Dolly Aguilera, Barunashish Brahma, Nathan J Robison, Erin Kiehna, Mark Krieger, Eric Sandler, Philipp Aldana, Ziad Khatib, John Ragheb, Sanjiv Bhatia, Sabine Mueller, Anu Banerjee, Amy-Lee Bredlau, Sri Gururangan, Herbert Fuchs, Kenneth J Cohen, George Jallo, Kathleen Dorris, Michael Handler, Melanie Comito, Mark Dias, Kellie Nazemi, Lissa Baird, Jeff Murray, Neal Lindeman, Jason L Hornick, Hayley Malkin, Claire Sinai, Lianne Greenspan, Karen D Wright, Michael Prados, Pratiti Bandopadhayay, Keith L Ligon, Mark W Kieran
Background: Diagnosis of diffuse intrinsic pontine gliomas (DIPG) has relied on imaging studies since the appearance is pathognomonic, and surgical risk was felt to be high and unlikely to affect therapy. The DIPG Biology and Treatment Study (DIPG-BATS) reported here incorporated a surgical biopsy at presentation and stratified subjects to receive FDA-approved agents chosen on the basis of specific biologic targets. Methods: Subjects were eligible for the trial if the clinical features and imaging appearance of a newly diagnosed tumor were consistent with a DIPG...
May 5, 2018: Neuro-oncology
https://www.readbyqxmd.com/read/29729878/2018-acc-hrs-nasci-scai-scct-expert-consensus-document-on-optimal-use-of-ionizing-radiation-in-cardiovascular-imaging-best-practices-for-safety-and-effectiveness-part-2-radiological-equipment-operation-dose-sparing-methodologies-patient-and-medical-personnel
#5
John W Hirshfeld, Victor A Ferrari, Frank M Bengel, Lisa Bergersen, Charles E Chambers, Andrew J Einstein, Mark J Eisenberg, Mark A Fogel, Thomas C Gerber, David E Haines, Warren K Laskey, Marian C Limacher, Kenneth J Nichols, Daniel A Pryma, Gilbert L Raff, Geoffrey D Rubin, Donnette Smith, Arthur E Stillman, Suma A Thomas, Thomas T Tsai, Louis K Wagner, L Samuel Wann
No abstract text is available yet for this article.
April 30, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29729877/2018-acc-hrs-nasci-scai-scct-expert-consensus-document-on-optimal-use-of-ionizing-radiation-in-cardiovascular-imaging-best-practices-for-safety-and-effectiveness-a-report-of-the-american-college-of-cardiology-task-force-on-expert-consensus-decision-pathways
#6
John W Hirshfeld, Victor A Ferrari, Frank M Bengel, Lisa Bergersen, Charles E Chambers, Andrew J Einstein, Mark J Eisenberg, Mark A Fogel, Thomas C Gerber, David E Haines, Warren K Laskey, Marian C Limacher, Kenneth J Nichols, Daniel A Pryma, Gilbert L Raff, Geoffrey D Rubin, Donnette Smith, Arthur E Stillman, Suma A Thomas, Thomas T Tsai, Louis K Wagner, L Samuel Wann
No abstract text is available yet for this article.
April 30, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29729876/2018-acc-hrs-nasci-scai-scct-expert-consensus-document-on-optimal-use-of-ionizing-radiation-in-cardiovascular-imaging-best-practices-for-safety-and-effectiveness-part-1-radiation-physics-and-radiation-biology
#7
John W Hirshfeld, Victor A Ferrari, Frank M Bengel, Lisa Bergersen, Charles E Chambers, Andrew J Einstein, Mark J Eisenberg, Mark A Fogel, Thomas C Gerber, David E Haines, Warren K Laskey, Marian C Limacher, Kenneth J Nichols, Daniel A Pryma, Gilbert L Raff, Geoffrey D Rubin, Donnette Smith, Arthur E Stillman, Suma A Thomas, Thomas T Tsai, Louis K Wagner, L Samuel Wann
No abstract text is available yet for this article.
April 30, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29727621/phosphatidylinositol-5-phosphate-4-kinases-regulate-cellular-lipid-metabolism-by-facilitating-autophagy
#8
Mark R Lundquist, Marcus D Goncalves, Ryan M Loughran, Elite Possik, Tarika Vijayaraghavan, Annan Yang, Chantal Pauli, Archna Ravi, Akanksha Verma, Zhiwei Yang, Jared L Johnson, Jenny C Y Wong, Yilun Ma, Katie Seo-Kyoung Hwang, David Weinkove, Nullin Divecha, John M Asara, Olivier Elemento, Mark A Rubin, Alec C Kimmelman, Arnim Pause, Lewis C Cantley, Brooke M Emerling
While the majority of phosphatidylinositol-4, 5-bisphosphate (PI-4, 5-P2 ) in mammalian cells is generated by the conversion of phosphatidylinositol-4-phosphate (PI-4-P) to PI-4, 5-P2 , a small fraction can be made by phosphorylating phosphatidylinositol-5-phosphate (PI-5-P). The physiological relevance of this second pathway is not clear. Here, we show that deletion of the genes encoding the two most active enzymes in this pathway, Pip4k2a and Pip4k2b, in the liver of mice causes a large enrichment in lipid droplets and in autophagic vesicles during fasting...
May 3, 2018: Molecular Cell
https://www.readbyqxmd.com/read/29727583/protein-tyrosine-phosphatase-n13-ptpn13-promotes-myofibroblast-resistance-to-apoptosis-in-idiopathic-pulmonary-fibrosis
#9
Alison Bamberg, Elizabeth F Redente, Steve D Groshong, Rubin M Tuder, Carlyne D Cool, Rebecca C Keith, Benjamin L Edelman, Bart P Black, Gregory P Cosgrove, Murry W Wynes, Douglas Curran-Everett, Stijn De Langhe, Luis A Ortiz, Andrew Thorburn, David W H Riches
RATIONALE: Idiopathic pulmonary fibrosis (IPF) is a progressive, fibrotic interstitial lung disease characterized by (myo)fibroblast accumulation and collagen deposition. Resistance to Fas-induced apoptosis is thought to facilitate (myo)fibroblast persistence in fibrotic lung tissues, by poorly understood mechanisms. OBJECTIVES: We tested the hypothesis that protein tyrosine phosphatase PTPN13 is expressed by IPF lung (myo)fibroblasts, promotes their resistance to Fas-induced apoptosis and contributes to the development of pulmonary fibrosis...
May 4, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29724426/acr-appropriateness-criteria-%C3%A2-chronic-wrist-pain
#10
David A Rubin, Catherine C Roberts, Jenny T Bencardino, Angela M Bell, R Carter Cassidy, Eric Y Chang, Soterios Gyftopoulos, Darlene F Metter, William B Morrison, Naveen Subhas, Siddharth Tambar, Jeffrey D Towers, Joseph S Yu, Mark J Kransdorf
Radiographs are indicated as the first imaging test in all patients with chronic wrist pain, regardless of the suspected diagnosis. When radiographs are normal or equivocal, advanced imaging with MRI (without or without intravenous contrast or following arthrography), CT (usually without contrast), and ultrasound each has a role in establishing a diagnosis. Furthermore, these examinations may contribute to staging disease, treatment planning, and prognostication, even when radiographs are diagnostic of a specific condition...
May 2018: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/29718244/burden-of-ulcerative-colitis-on-functioning-and-well-being-a-systematic-literature-review-of-the-sf-36%C3%A2-health-survey
#11
Aaron Yarlas, David T Rubin, Julian Panés, James O Lindsay, Séverine Vermeire, Martha Bayliss, Joseph C Cappelleri, Stephen Maher, Andrew G Bushmakin, Lea Ann Chen, Marco DiBonaventura
Background and Aims: This review is the first to evaluate the burden of ulcerative colitis [UC] on patients' quality of life by synthesizing data from studies comparing scores from the SF-36® Health Survey, a generic measure assessing eight quality-of-life domains, between UC patients and matched reference samples. Methods: A systematic review of the published literature identified articles reporting SF-36 domains or physical and mental component summary scores [PCS, MCS] from UC and reference samples...
April 27, 2018: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29701124/the-use-of-tofacitinib-in-the-treatment-of-inflammatory-bowel-disease
#12
Roni Weisshof, Maya Aharoni Golan, Olivia V Yvellez, David T Rubin
Janus kinases (JAK) play a major role in the immunologic pathways and specifically in signal transduction in inflammatory bowel disease. Thus, they can serve as a target for new therapeutic options. Tofacitinib is a novel, first-in-class, pan-Janus kinase inhibitor. It has been found to be effective and safe in the treatment of moderate-to-severe ulcerative colitis. In this review, we will describe the drug's mechanism of action as well as the clinical evidence for its effectiveness in treating patients with inflammatory bowel disease...
April 27, 2018: Immunotherapy
https://www.readbyqxmd.com/read/29697188/biodegradable-silk-catheters-for-the-delivery-of-therapeutics-across-anatomical-repair-sites
#13
Joseph E Brown, Lorenzo Tozzi, Benjamin Schilling, Arta Kelmendi-Doko, April B Truong, Maria J Rodriguez, Eun Seok Gil, Robert Sucsy, Jolene E Valentin, Brian J Philips, Kacey G Marra, J Peter Rubin, David L Kaplan
Biodegradable silk catheters for the delivery of therapeutics are designed with a focus on creating porous gradients that can direct the release of molecules away from the implantation site. Though suitable for a range of applications, these catheters are designed for drug delivery to transplanted adipose tissue in patients having undergone a fat grafting procedure. A common complication for fat grafts is the rapid reabsorption of large volume adipose transplants. In order to prolong volume retention, biodegradable catheters can be embedded into transplanted tissue to deliver nutrients, growth factors or therapeutics to improve adipocyte viability, proliferation, and ultimately extend volume retention...
April 26, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29688409/methotrexate-for-the-treatment-of-pediatric-crohn-s-disease-a-systematic-review-and-meta-analysis
#14
Ruben J Colman, Rachel C Lawton, Marla C Dubinsky, David T Rubin
Background: Methotrexate (MTX) is an immunomodulator used for the treatment of pediatric inflammatory bowel disease (IBD). There are currently no RCTs that assess the treatment efficacy of methotrexate within the pediatric IBD patient population. This systematic review and meta-analysis assesses the efficacy of MTX therapy among the existing pediatric literature. Methods: A systematic literature search was performed using MEDLINE and the Cochrane library from inception until March 2016...
April 23, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29686426/transcript-indexed-atac-seq-for-precision-immune-profiling
#15
Ansuman T Satpathy, Naresha Saligrama, Jason D Buenrostro, Yuning Wei, Beijing Wu, Adam J Rubin, Jeffrey M Granja, Caleb A Lareau, Rui Li, Yanyan Qi, Kevin R Parker, Maxwell R Mumbach, William S Serratelli, David G Gennert, Alicia N Schep, M Ryan Corces, Michael S Khodadoust, Youn H Kim, Paul A Khavari, William J Greenleaf, Mark M Davis, Howard Y Chang
T cells create vast amounts of diversity in the genes that encode their T cell receptors (TCRs), which enables individual clones to recognize specific peptide-major histocompatibility complex (MHC) ligands. Here we combined sequencing of the TCR-encoding genes with assay for transposase-accessible chromatin with sequencing (ATAC-seq) analysis at the single-cell level to provide information on the TCR specificity and epigenomic state of individual T cells. By using this approach, termed transcript-indexed ATAC-seq (T-ATAC-seq), we identified epigenomic signatures in immortalized leukemic T cells, primary human T cells from healthy volunteers and primary leukemic T cells from patient samples...
April 23, 2018: Nature Medicine
https://www.readbyqxmd.com/read/29668420/queering-biology-gutting-feminism-a-review-essay-of-gut-feminism-by-elizabeth-a-wilson-durham-nc-duke-university-press-2015
#16
David A Rubin
The author reviews Elizabeth A. Wilson's Gut Feminism (2015), arguing that Wilson's book productively challenges some of feminist theory's most entrenched presuppositions: that social, cultural, and discursive frameworks are opposed and superior to biological ones; that biological matter is flat, sovereign, monolithic, and determining; that depression is more a cultural, historical, and psychological phenomenon than a biochemical and pharmaceutical one (and that these nominative distinctions are stable and natural); and finally, that the belly's ruminations (hunger, ingestion, digestion, peristalsis, diarrhea, constipation, and excretion) give no clue as to the complexities of entanglements between gut, psyche, subjectivity, sociality, and hostility...
April 3, 2018: Journal of Lesbian Studies
https://www.readbyqxmd.com/read/29623289/support-for-self-management-and-prenatal-health-behavior-change-implications-for-pediatric-promotion-of-interconception-care
#17
Emily F Gregory, Charmaine S Wright, Meredith Matone, David M Rubin, Scott A Lorch
Pediatricians increasingly endorse a dual generation approach to health, in which parental health behaviors are recognized as critical to promoting child health. Positive parental behaviors often emerge during pregnancy, for reasons that remain incompletely described. We surveyed mothers in the immediate postpartum period to identify beliefs about health behavior change and characteristics of prenatal care associated with successful change. Sampling at a tertiary care hospital captured an English-speaking adult population with healthy infants...
2018: Global Pediatric Health
https://www.readbyqxmd.com/read/29617381/prevention-of-colonic-neoplasia-with-polyethylene-glycol-a-short-term-randomized-placebo-controlled-double-blinded-trial
#18
Ramesh K Wali, Laura Bianchi, Sonia Kupfer, Mart De La Cruz, Borko Jovanovic, Christopher Weber, Michael J Goldberg, L M Rodriguez, Raymond Bergan, David Rubin, Mary Beth Tull, Ellen Richmond, Beth Parker, Seema Khan, Hemant K Roy
Chemoprevention represents an attractive modality against colorectal cancer (CRC) although widespread clinical implementation of promising agents (e.g. aspirin/NSAIDS) have been stymied by both suboptimal efficacy and concerns over toxicity. This highlights the need for better agents. Several groups, including our own, have reported that the over-the-counter laxative polyethylene glycol (PEG) has remarkable efficacy in rodent models of colon carcinogenesis. In this study, we undertook the first randomized human trial to address the role of PEG in prevention of human colonic neoplasia...
2018: PloS One
https://www.readbyqxmd.com/read/29610475/the-long-tail-of-oncogenic-drivers-in-prostate-cancer
#19
Joshua Armenia, Stephanie A M Wankowicz, David Liu, Jianjiong Gao, Ritika Kundra, Ed Reznik, Walid K Chatila, Debyani Chakravarty, G Celine Han, Ilsa Coleman, Bruce Montgomery, Colin Pritchard, Colm Morrissey, Christopher E Barbieri, Himisha Beltran, Andrea Sboner, Zafeiris Zafeiriou, Susana Miranda, Craig M Bielski, Alexander V Penson, Charlotte Tolonen, Franklin W Huang, Dan Robinson, Yi Mi Wu, Robert Lonigro, Levi A Garraway, Francesca Demichelis, Philip W Kantoff, Mary-Ellen Taplin, Wassim Abida, Barry S Taylor, Howard I Scher, Peter S Nelson, Johann S de Bono, Mark A Rubin, Charles L Sawyers, Arul M Chinnaiyan, Nikolaus Schultz, Eliezer M Van Allen
Comprehensive genomic characterization of prostate cancer has identified recurrent alterations in genes involved in androgen signaling, DNA repair, and PI3K signaling, among others. However, larger and uniform genomic analysis may identify additional recurrently mutated genes at lower frequencies. Here we aggregate and uniformly analyze exome sequencing data from 1,013 prostate cancers. We identify and validate a new class of E26 transformation-specific (ETS)-fusion-negative tumors defined by mutations in epigenetic regulators, as well as alterations in pathways not previously implicated in prostate cancer, such as the spliceosome pathway...
April 2, 2018: Nature Genetics
https://www.readbyqxmd.com/read/29608558/high-throughput-interaction-screens-illuminate-the-role-of-c-di-amp-in-cyanobacterial-nighttime-survival
#20
Benjamin E Rubin, TuAnh Ngoc Huynh, David G Welkie, Spencer Diamond, Ryan Simkovsky, Emily C Pierce, Arnaud Taton, Laura C Lowe, Jenny J Lee, Scott A Rifkin, Joshua J Woodward, Susan S Golden
The broadly conserved signaling nucleotide cyclic di-adenosine monophosphate (c-di-AMP) is essential for viability in most bacteria where it has been studied. However, characterization of the cellular functions and metabolism of c-di-AMP has largely been confined to the class Bacilli, limiting our functional understanding of the molecule among diverse phyla. We identified the cyclase responsible for c-di-AMP synthesis and characterized the molecule's role in survival of darkness in the model photosynthetic cyanobacterium Synechococcus elongatus PCC 7942...
April 2, 2018: PLoS Genetics
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