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JOURNAL ARTICLE
Christian D Pulcini, Xianqun Luan, Elizabeth S Brooks, Annique Hogan, Tina Penrose, Chen C Kenyon, David M Rubin
Improving the overall care of children with medical complexity (CMC) is often beset by challenges in proactively identifying the population most in need of clinical management and quality improvement. The objective of the current study was to create a system to better capture longitudinal risk for sustained and elevated utilization across time using real-time electronic health record (EHR) data. A new Pediatric Population Management Classification (PPMC), drawn from visit diagnoses and continuity problem lists within the EHR of a tristate health system, was compared with an existing complex chronic conditions (CCC) system for agreement (with weighted κ) on identifying CCMC, as well as persistence of elevated charges and utilization from 2016 to 2019...
April 13, 2024: Population Health Management
#2
Florian Buerger, Daanya Salmanullah, Lorrin Liang, Victoria Gauntner, Kavita Krueger, Maggie Qi, Vineeta Sharma, Alexander Rubin, David Ball, Katharina Lemberg, Ken Saida, Lea Maria Merz, Sanja Sever, Biju Issac, Liang Sun, Sergio Guerrero-Castillo, Alexis C Gomez, Michelle T McNulty, Matthew G Sampson, Mohamed H Al-Hamed, Mohammed M Saleh, Mohamed Shalaby, Jameela Kari, James P Fawcett, Friedhelm Hildebrandt, Amar J Majmundar
In genetic disease, an accurate expression landscape of disease genes and faithful animal models will enable precise genetic diagnoses and therapeutic discoveries, respectively. We previously discovered that variants in NOS1AP , encoding nitric oxide synthase 1 (NOS1) adaptor protein, cause monogenic nephrotic syndrome (NS). Here, we determined that an intergenic splice product of N OS1AP / Nos1ap and neighboring C1orf226/Gm7694 , which precludes NOS1 binding, is the predominant isoform in mammalian kidney transcriptional and proteomic data...
March 21, 2024: medRxiv
#3
JOURNAL ARTICLE
Mariangela Allocca, Cecilia Dell'Avalle, Alessandra Zilli, Federica Furfaro, Ferdinando D'Amico, Vipul Jairath, David T Rubin, Laurent Peyrin-Biroulet, Gionata Fiorino, Silvio Danese
BACKGROUND: The Bowel Ultrasound Score (BUSS) accurately detects therapy-related changes by using the Simple Endoscopic Score for Crohn's disease (SES-CD) as the reference standard. We aimed to evaluate ultrasound remission as a treatment target and its prediction for long-term endoscopic remission. METHODS: This single-centre prospective observational study, based at a tertiary referral centre in Milan, Italy, enrolled, between March 1, 2018, and January 31, 2021, adult patients with active CD (SES-CD >2) who were starting biologics...
May 2024: EClinicalMedicine
#4
JOURNAL ARTICLE
Dorthe Berntsen, David C Rubin
Collective future thinking is a budding research field concerned with the act of imagining possible events in the future of a collective-typically one's nation. Prior research has shown that people imagine more positive than negative events in the personal future but more negative than positive events in the collective future. This interaction has been interpreted as a valence-based dissociation between collective and personal cognition. We examine if degrees of self-relatedness may account for these effects...
March 28, 2024: Journal of Experimental Psychology. General
#5
JOURNAL ARTICLE
Monica Gori, David Burr, Claudio Campus
An important task for the visual system is to identify and segregate objects from background. Figure-ground illusions, such as Edgar Rubin's bistable 'vase-faces illusion'1 , make the point clearly: we see either a central vase or lateral faces, alternating spontaneously, but never both images simultaneously. The border is perceptually assigned to either faces or vase, which become figure, the other shapeless background2 . The stochastic alternation between figure and ground probably reflects mutual inhibitory processes that ensure a single perceptual outcome3 ...
March 25, 2024: Current Biology: CB
#6
JOURNAL ARTICLE
Hannah Posner, Rachel Lombard, Shintaro Akiyama, Nathaniel A Cohen, David T Rubin, Marla C Dubinsky, Sushila Dalal, Maia Kayal
INTRODUCTION: To better inform the risk of cuffitis in patients with ulcerative colitis (UC), we aimed to identify its occurrence and associated precolectomy factors in a large multicenter cohort of patients who underwent restorative proctocolectomy (RPC) with stapled ileal pouch-anal anastomosis (IPAA). METHODS: This study was a retrospective cohort analysis of individuals diagnosed with UC or indeterminate colitis who underwent RPC with IPAA for refractory disease or dysplasia at Mount Sinai Hospital or the University of Chicago followed by at least 1 pouchoscopy with report of the pouch-anal anastomosis...
March 23, 2024: Inflammatory Bowel Diseases
#7
JOURNAL ARTICLE
Sarah Shahub, Ruchita Mahesh Kumar, Kai-Chun Lin, Ivneet Banga, Natalie K Choi, Nicole M Garcia, Sriram Muthukumar, David T Rubin, Shalini Prasad
BACKGROUND: Wearable sensor devices represent a noninvasive technology to continuously track biomarkers linked to inflammatory bowel disease (IBD). We assessed the inflammatory markers associated with IBD in human perspiration. METHODS: Participants with IBD were monitored for 40 to 130 minutes with a proprietary wearable sensor device used to measure C-reactive protein, interleukin-6, and calprotectin. Sensor response using electrochemical impedance spectroscopy and serum samples were measured on the same day...
March 23, 2024: Inflammatory Bowel Diseases
#8
JOURNAL ARTICLE
Mattia Trunfio, Bin Tang, Oluwakemi Okwuegbuna, Jennifer E Iudicello, Ajay Bharti, David J Moore, Benjamin B Gelman, Susan Morgello, Payal B Patel, Leah H Rubin, Beau M Ances, Sara Gianella, Robert K Heaton, Ronald J Ellis, Scott L Letendre
Interindividual variation of human immunodeficiency virus (HIV) RNA setpoint in cerebrospinal fluid (CSF) and its determinants are poorly understood, but relevant for HIV neuropathology, brain reservoirs, viral escape, and reseeding after antiretroviral interruptions. Longitudinal multicentric study on demographic, clinical, and laboratory correlates of CSF HIV RNA in 2000 follow-up visits from 597 people with HIV (PWH) off antiretroviral therapy (ART) and with plasma HIV RNA > the lower limit of quantification (LLQ)...
March 2024: Journal of Medical Virology
#9
JOURNAL ARTICLE
Xiaoguang Xu, Chachrit Khunsriraksakul, James M Eales, Sebastien Rubin, David Scannali, Sushant Saluja, David Talavera, Havell Markus, Lida Wang, Maciej Drzal, Akhlaq Maan, Abigail C Lay, Priscilla R Prestes, Jeniece Regan, Avantika R Diwadkar, Matthew Denniff, Grzegorz Rempega, Jakub Ryszawy, Robert Król, John P Dormer, Monika Szulinska, Marta Walczak, Andrzej Antczak, Pamela R Matías-García, Melanie Waldenberger, Adrian S Woolf, Bernard Keavney, Ewa Zukowska-Szczechowska, Wojciech Wystrychowski, Joanna Zywiec, Pawel Bogdanski, A H Jan Danser, Nilesh J Samani, Tomasz J Guzik, Andrew P Morris, Dajiang J Liu, Fadi J Charchar, Maciej Tomaszewski
Genetic mechanisms of blood pressure (BP) regulation remain poorly defined. Using kidney-specific epigenomic annotations and 3D genome information we generated and validated gene expression prediction models for the purpose of transcriptome-wide association studies in 700 human kidneys. We identified 889 kidney genes associated with BP of which 399 were prioritised as contributors to BP regulation. Imputation of kidney proteome and microRNAome uncovered 97 renal proteins and 11 miRNAs associated with BP. Integration with plasma proteomics and metabolomics illuminated circulating levels of myo-inositol, 4-guanidinobutanoate and angiotensinogen as downstream effectors of several kidney BP genes (SLC5A11, AGMAT, AGT, respectively)...
March 19, 2024: Nature Communications
#10
REVIEW
Matthew P Kirschen, Ariane Lewis, Michael A Rubin, Panayiotis N Varelas, David M Greer
Normothermic regional perfusion (NRP) has recently been used to augment organ donation after circulatory death (DCD) to improve the quantity and quality of transplantable organs. In DCD-NRP, after withdrawal of life-sustaining therapies and cardiopulmonary arrest, patients are cannulated onto extracorporeal membrane oxygenation to reestablish blood flow to targeted organs including the heart. During this process, aortic arch vessels are ligated to restrict cerebral blood flow. We review ethical challenges including whether the brain is sufficiently reperfused through collateral circulation to allow reemergence of consciousness or pain perception, whether resumption of cardiac activity nullifies the patient's prior death determination, and whether specific authorization for DCD-NRP is required...
March 19, 2024: Annals of Neurology
#11
JOURNAL ARTICLE
Beate S Müller, Dagmar Lüttel, Dania Schütze, Tatjana Blazejewski, Marina Pommée, Hardy Müller, Katharina Rubin, Christian Thomeczek, Romy Schadewitz, Reiner Heuzeroth, David Schwappach, Corina Güthlin, Michael Paulitsch, Ferdinand M Gerlach
BACKGROUND: To improve patient safety, it is important that healthcare facilities learn from critical incidents. Tools such as reporting and learning systems and team meetings structure error management and promote learning from incidents. To enhance error management in ambulatory care practices, it is important to promote a climate of safety and ensure personnel share views on safety policies and procedures. In contrast to the hospital sector, little research has been dedicated to developing feasible approaches to supporting error management and safety climate in ambulatory care...
March 18, 2024: Journal of Patient Safety
#12
REVIEW
Shintaro Akiyama, Yusuke Miyatani, David T Rubin
A therapeutic goal for patients with ulcerative colitis (UC) is deep remission including clinical remission and mucosal healing. Mucosal healing was previously defined by endoscopic appearance, but recent studies demonstrate that histological improvements can minimize the risks of experiencing clinical relapse after achieving endoscopic remission, and there is growing interest in the value and feasibility of histological targets of treatment in inflammatory bowel disease, and specifically UC. In this review article, we identify remaining challenges and discuss an evolving role of histology in the management of UC...
March 13, 2024: Intestinal Research
#13
JOURNAL ARTICLE
Can Özütemiz, Yasemin Koksel, Jerry W Froelich, Nathan Rubin, Maneesh Bhargava, Henri Roukoz, Rebecca Cogswell, Jeremy Markowitz, David M Perlman, Daniel Steinberger
OBJECTIVE: Papillary muscle (PM) activity may demonstrate true active cardiac sarcoidosis (CS) or mimic CS in 18 FDG-PET/CT if adequate myocardial suppression (MS) is not achieved. We aim to examine whether PM uptake can be used as a marker of failed MS and measure the rate of PM activity presence in active CS with different dietary preparations. MATERIALS AND METHODS: We retrospectively reviewed PET/CTs obtained with three different dietary preparations. Diet-A: 24-h ketogenic diet with overnight fasting (n = 94); Diet-B: 18-h fasting (n = 44); and Diet-C: 72-h daytime ketogenic diet with 3-day overnight fasting (n = 98)...
March 2, 2024: Annals of Nuclear Medicine
#14
JOURNAL ARTICLE
Jonah Rubin, Alison S Witkin, Jerome C Crowley, Eriberto Michel, David M Furfaro, Ricardo Teijeiro-Paradis, Annette Ilg, Raghu Seethala, Sophia Zhao, Eddy Fan
BACKGROUND: Use of venovenous extracorporeal membrane oxygenation (ECMO) is increasing, but candidacy selection processes are variable and subject to bias. RESEARCH QUESTION: What are the reasons behind venovenous ECMO candidacy decisions, and are decisions made consistently across patients? STUDY DESIGN AND METHODS: Prospective observational study of all patients, admitted or outside hospital referrals, considered for venovenous ECMO at a tertiary referral center...
February 27, 2024: Chest
#15
JOURNAL ARTICLE
Yixiao Zhang, Sri Madabhushi, Tiffany Tang, Hassan Raza, David J Busch, Xi Zhao, James Ormes, Sen Xu, Joseph Moroney, Rubin Jiang, Henry Lin, Ren Liu
Hollow fiber filter fouling is a common issue plaguing perfusion production process for biologics therapeutics, but the nature of filter foulant has been elusive. Here we studied cell culture materials especially Chinese hamster ovary (CHO) cell-derived extracellular vesicles in perfusion process to determine their role in filter fouling. We found that the decrease of CHO-derived small extracellular vesicles (sEVs) with 50-200 nm in diameter in perfusion permeates always preceded the increase in transmembrane pressure (TMP) and subsequent decrease in product sieving, suggesting that sEVs might have been retained inside filters and contributed to filter fouling...
February 19, 2024: Biotechnology and Bioengineering
#16
JOURNAL ARTICLE
Dinah Foer, David M Rubins, Vi Nguyen, Alex McDowell, Meg Quint, Mitchell Kellaway, Sari L Reisner, Li Zhou, David W Bates
OBJECTIVES: Despite federally mandated collection of sex and gender demographics in the electronic health record (EHR), longitudinal assessments are lacking. We assessed sex and gender demographic field utilization using EHR metadata. MATERIALS AND METHODS: Patients ≥18 years of age in the Mass General Brigham health system with a first Legal Sex entry (registration requirement) between January 8, 2018 and January 1, 2022 were included in this retrospective study...
February 2, 2024: Journal of the American Medical Informatics Association: JAMIA
#17
JOURNAL ARTICLE
Umer Nadir, Michael D Yi, Eric Koza, Victoria J Shi, Loma Dave, Farhana Ikmal Hisham, Amanda Maisel-Campbell, Katherine A Lin, Sarah A Ibrahim, Bianca Y Kang, Noor Anvery, McKenzie A Dirr, Rachel E Christensen, Julia M Riley, Roopal V Kundu, Juliet L Aylward, Omar Bari, Hamza Bhatti, Diana Bolotin, Basil S Cherpelis, Joel L Cohen, Sean Condon, Sheila Farhang, Bahar Firoz, Algin B Garrett, Roy G Geronemus, Nicholas J Golda, Tatyana R Humphreys, Eva A Hurst, Oren H Jacobson, S Brian Jiang, Pritesh S Karia, Arash Kimyai-Asadi, David J Kouba, M Laurin Council, Marilyn Le, Deborah F MacFarlane, Ian A Maher, Stanley J Miller, Eduardo K Moioli, Meghan Morrow, Julia Neckman, Samuel R Peterson, Christine Poblete-Lopez, Chad L Prather, Jennifer S Ranario, Ashley G Rubin, Andrew M Swanson, Christopher Urban, Y Gloria Xu, Ross Pearlman, Brian A Cahn, Simon Yoo, Vishnu Harikumar, Alexandra Weil, Matthew Schaeffer, Sanjana Iyengar, Emily Poon, Murad Alam
No abstract text is available yet for this article.
January 29, 2024: Journal of the American Academy of Dermatology
#18
JOURNAL ARTICLE
Mohammad Zamani, Forough Ebrahimtabar, Shaghayegh Alizadeh-Tabari, Scott E Kasner, Mitchell S V Elkind, Ashwin N Ananthakrishnan, Tenzin Choden, David T Rubin, Reza Malekzadeh
BACKGROUND: Several studies investigated the risks of neurological conditions in patients with inflammatory bowel disease (IBD), with some variability in findings. We aimed to perform a systematic review and meta-analysis of available evidence to elucidate the association between IBD and the risks of common neurological disorders. METHODS: We conducted a literature search through Embase, PubMed, Scopus, and ProQuest databases from inception to June 30, 2023, to identify cohort studies assessing the risk of developing stroke, all-cause dementia, Parkinson's disease (PD), multiple sclerosis (MS), seizure/epilepsy, and peripheral neuropathy in adult IBD patients compared with non-IBD population...
January 25, 2024: Inflammatory Bowel Diseases
#19
Seulki Kwon, Jordan Safer, Duyen T Nguyen, David Hoksza, Patrick May, Jeremy A Arbesfeld, Alan F Rubin, Arthur J Campbell, Alex Burgin, Sumaiya Iqbal
Recent advances in AI-based methods have revolutionized the field of structural biology. Concomitantly, high-throughput sequencing and functional genomics technologies have enabled the detection and generation of variants at an unprecedented scale. However, efficient tools and resources are needed to link these two disparate data types - to "map" variants onto protein structures, to better understand how the variation causes disease and thereby design therapeutics. Here we present the Genomics 2 Proteins Portal (G2P; g2p...
January 2, 2024: bioRxiv
#20
JOURNAL ARTICLE
Taylor D Ottesen, Michael Amick, David S Kirwin, Michael R Mercier, Jordan Brand, David B Frumberg, Jonathan N Grauer, Lee E Rubin
INTRODUCTION: The effect of orthopaedic fellowship subspecialization on surgical complications for patients with supracondylar fracture is unknown. This study seeks to compare the effect of subspecialty training on supracondylar fracture complications. METHODS: The American Board of Orthopaedic Surgery Part II Examination Case List database was reviewed for all supracondylar fractures from 1999 to 2016. Procedures were divided by fellowship subspecialty (trauma, pediatric, or other) and case volume and assessed by surgeon-reported surgical complications...
January 1, 2024: Journal of the American Academy of Orthopaedic Surgeons. Global Research & Reviews
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