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https://www.readbyqxmd.com/read/28078602/sulfatides-primarily-exist-in-the-substantia-nigra-region-of-mouse-brain-tissue
#1
Kab-Tae Park, Jong Cheol Shon, Ji-Eun Kim, Gyu Hwan Park, Hyun Jin Choi, Kwang-Hyeon Liu
Lipid distribution in the brain is important for many biological functions and has been associated with some brain diseases. The aim of this study was to investigate lipid distribution in different regions of brain tissue in mice. To this end, substantia nigra (SN), caudate putamen (CPu), hippocampus (Hip), hypothalamus (Hyp), and cortex (Cx) tissues of mice were analyzed using direct infusion nanoelectrospray-ion trap mass spectrometry and multivariate analyses. The SN, CPu, Hip, Hyp, and Cx groups showed clear differences in lipid distribution using principal component analysis and a partial least-squares discriminant analysis score plot, and lipid levels were significantly different in different brain regions...
January 11, 2017: Lipids
https://www.readbyqxmd.com/read/28075482/human-induced-pluripotent-stem-hips-cells-from-urine-samples-a-non-integrative-and-feeder-free-reprogramming-strategy
#2
Clara Steichen, Karim Si-Tayeb, Fanny Wulkan, Thayane Crestani, Graça Rosas, Rafael Dariolli, Alexandre C Pereira, Jose E Krieger
Human induced pluripotent stem (hiPS) cell technology has already revolutionized some aspects of fundamental and applied research such as study of disease mechanisms and pharmacology screening. The first clinical trial using hiPS cell-derived cells began in Japan, only 10 years after the publication of the proof-of concept article. In this exciting context, strategies to generate hiPS cells have evolved quickly, tending towards non-invasive protocols to sample somatic cells combined with "safer" reprogramming strategies...
January 11, 2017: Current Protocols in Human Genetics
https://www.readbyqxmd.com/read/28074257/outcomes-of-dual-mobility-cups-in-a-young-middle-eastern-population-and-its-influence-on-life-style
#3
Chahine Assi, Elie El-Najjar, Camille Samaha, Kaissar Yammine
Dual mobility cups (DMC) in total hip arthroplasty (THA) are becoming popular among orthopaedic surgeons. Substantial benefit of their use has been reported among high risk patients, particularly in reducing post-operative hip instability (dislocation). Many reports stated some concern when implanted in young and active people where complications such as polyethylene wear and mechanical loosening could potentially be higher. This Middle Eastern study analyses a retrospective series of THA for any aetiology other than infection, using DMC for the acetabular component in 75 patients (85 implants) less than 70 years old...
January 10, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28072898/three-year-results-with-a-ringless-third-generation-porous-plasma-sprayed-acetabular-component-in-primary-total-hip-arthroplasty
#4
Keith R Berend, Joanne B Adams, Michael J Morris, Adolph V Lombardi
INTRODUCTION: We previously reported promising early results in patients undergoing primary total hip arthroplasty (THA) with a third-generation cementless acetabular system that has a porous plasma-sprayed coating on a titanium alloy substrate shell, a ringless barb and groove locking mechanism, and a vitamin E-infused highly crosslinked polyethylene insert. The purpose of this study was to examine the outcomes and need for revision in a subset of patients previously reviewed who now have potential for three-year follow-up...
January 10, 2017: Surgical Technology International
https://www.readbyqxmd.com/read/28070611/dual-mobility-cups-provide-biomechanical-advantages-in-situations-at-risk-for-dislocation-a-finite-element-analysis
#5
Alexandre Terrier, Adeliya Latypova, Maika Guillemin, Valérie Parvex, Olivier Guyen
PURPOSE: Constrained devices, standard implants with large heads, and dual mobility systems have become popular options to manage instability after total hip arthroplasty (THA). Clinical results with these options have shown variable success rates and significant higher rates of aseptic loosening and mechanical failures with constrained implants. Literature suggests potential advantages of dual mobility, however little is known about its biomechanics. We present a comparative biomechanical study of a standard implant, a constrained implant, and a dual mobility system...
January 9, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28066745/deep-gluteal-space-problems-piriformis-syndrome-ischiofemoral-impingement-and-sciatic-nerve-release
#6
Luis Perez Carro, Moises Fernandez Hernando, Luis Cerezal, Ivan Saenz Navarro, Ana Alfonso Fernandez, Alexander Ortiz Castillo
BACKGROUND: Deep gluteal syndrome (DGS) is an underdiagnosed entity characterized by pain and/or dysesthesias in the buttock area, hip or posterior thigh and/or radicular pain due to a non-discogenic sciatic nerve entrapment in the subgluteal space. Multiple pathologies have been incorporated in this all-included "piriformis syndrome", a term that has nothing to do with the presence of fibrous bands, obturator internus/gemellus syndrome, quadratus femoris/ischiofemoral pathology, hamstring conditions, gluteal disorders and orthopedic causes...
July 2016: Muscles, Ligaments and Tendons Journal
https://www.readbyqxmd.com/read/28065627/revision-total-hip-and-knee-arthroplasties-after-solid-organ-transplant
#7
Cameron K Ledford, Joseph M Statz, Brian P Chalmers, Kevin I Perry, Arlen D Hanssen, Matthew P Abdel
BACKGROUND: As solid organ transplant (SOT) patients' survival improves, the number undergoing total hip (THA) and total knee arthroplasty (TKA) is increasing. Accordingly, the number of revision procedures in this higher-risk group is also increasing. The goals of this study were to identify the most common failure mechanisms, associated complications, clinical outcomes, and patient survivorship of SOT patients after revision THA or TKA. METHODS: A retrospective review identified 39 revision procedures (30 revision THAs and 9 revision TKAs) completed in 37 SOT patients between 2000 and 2013...
December 11, 2016: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28064540/romosozumab-for-the-treatment-of-osteoporosis
#8
Leonardo Bandeira, E Michael Lewiecki, John P Bilezikian
Introduction Sclerostin, a glycoprotein produced primarily by osteocytes, blocks the canonical Wnt signaling bone formation pathway. Romosozumab is a humanized monoclonal antibody to sclerostin that binds to sclerostin, permitting the engagement of Wnt ligands with their co-receptors, resulting in an increase in bone formation and bone mineral density (BMD). Clinical studies with romosozumab have shown dramatic improvements in BMD at the spine and hip. Romosozumab is associated with improvement in bone strength through mechanisms that include increases in bone formation and, different from classical osteoanabolic agents, suppression of bone resorption...
January 9, 2017: Expert Opinion on Biological Therapy
https://www.readbyqxmd.com/read/28064103/why-do-some-titanium-alloy-total-hip-arthroplasty-modular-necks-fail
#9
Samo K Fokter, Andrej Moličnik, Rajko Kavalar, Primož Pelicon, Rebeka Rudolf, Nenad Gubeljak
BACKGROUND: Increased modularity in total hip arthroplasty (THA) through extra junction between the neck and the femoral stem is gaining popularity among orthopaedic community. However, the advantage of the additional junction is shadowed by an increased risk of mechanical failure. The aim of this study was to describe the exact mechanism of fracture of the modular femoral neck in an uncemented stem. METHODS: Clinical, metallurgical, and mechanical analysis including finite-element modelling and elemental-sensitive tissue analysis with the micro-PIXE method was performed on two patients treated with fully modular primary THA made from Titanium alloy of the same oval taper-cone design...
December 27, 2016: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28062423/prominent-metalware-from-pelvic-surgery-causing-dyspareunia
#10
Mithun Nambiar, Samuel Raymond Heaton, Andrew John Stevenson, Andrew Thomas Bucknill
We present a case of female dyspareunia secondary to metalware placement during extensive pelvic surgery following a motor vehicle accident. The patient initially had an uneventful recovery from her operations. However, she noticed pain with vaginal intercourse, due to a screw tip which was palpable on vaginal examination. X-ray imaging confirmed long screws in the medial part of an anterior column plate, which were impacting on the anterior vaginal wall. Subsequent percutaneous removal of two screws resulted in resolution of her symptoms of painful vaginal intercourse...
January 6, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28061849/do-size-shape-and-alignment-parameters-of-the-femoral-condyle-affect-the-trochlear-groove-tracking-a-morphometric-study-based-on-3d-computed-tomography-models-in-chinese-people
#11
Zhe Du, Shichang Chen, Mengning Yan, Bing Yue, Yiming Zeng, You Wang
BACKGROUND: Our study aimed to investigate whether geometrical features (size, shape, or alignment parameters) of the femoral condyle affect the morphology of the trochlear groove. METHODS: Computed tomography models of 195 femurs (97 and 98 knees from male and female subjects, respectively) were reconstructed into three-dimensional models and categorised into four types of trochlear groove morphology based on the position of the turning point in relation to the mechanical axis (types 45°, 60°, 75°, and 90°)...
January 6, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28060826/association-of-hip-bone-mineral-density-and-body-composition-in-a-rural-indian-population-the-andhra-pradesh-children-and-parents-study-apcaps
#12
Mika Matsuzaki, Bharati Kulkarni, Hannah Kuper, Jonathan C Wells, George B Ploubidis, Poornima Prabhakaran, Vipin Gupta, Gagandeep Kaur Walia, Aastha Aggarwal, Dorairaj Prabhakaran, George Davey Smith, Kankipati Vijaya Radhakrishna, Yoav Ben-Shlomo, Sanjay Kinra
BACKGROUND: Fat mass is variably associated with bone mass, possibly due to differential mechanical and biological effects of fat mass. We examined the association of fat mass with bone mass in a lean population. OBJECTIVE: To investigate association between hip bone mineral density and fat and lean mass in a cross-sectional study from southern India. DESIGN: The Andhra Pradesh Children and Parents Study is a prospective cohort study in Hyderabad, India...
2017: PloS One
https://www.readbyqxmd.com/read/28057348/lower-extremity-control-during-turns-initiated-with-and-without-hip-external-rotation
#13
Antonia M Zaferiou, Henryk Flashner, Rand R Wilcox, Jill L McNitt-Gray
The pirouette turn is often initiated in neutral and externally rotated hip positions by dancers. This provides an opportunity to investigate how dancers satisfy the same mechanical objectives at the whole-body level when using different leg kinematics. The purpose of this study was to compare lower extremity control strategies during the turn initiation phase of pirouettes performed with and without hip external rotation. Skilled dancers (n=5) performed pirouette turns with and without hip external rotation...
December 29, 2016: Journal of Biomechanics
https://www.readbyqxmd.com/read/28057320/chief-complaints-of-elderly-individuals-on-presentation-to-emergency-department-a-retrospective-analysis-of-south-korean-national-data-2014
#14
Misoon Song, Xianglan Jin, Ha Na Ko, Sunghee H Tak
PURPOSE: We aimed to assess the chief complaints (CCs) of elderly individuals on presentation to the emergency department (ED) according to gender, age, and disease-related and injury-related visits. METHODS: The 2014 registry database of the National Emergency Department Information System in South Korea, which included data on 908,761 ED visits by individuals aged 65 years and over, was reviewed. RESULTS: We found that 80.7% ED visits were related to disease, whereas the remaining visits were related to injury...
December 2016: Asian Nursing Research
https://www.readbyqxmd.com/read/28049238/the-curves-exercise-suppresses-endotoxemia-in-korean-women-with-obesity
#15
Seon Ah Jin, Sun Kyeong Kim, Hee Jung Seo, Mijoo Kim, Kye Taek Ahn, Jun Hyung Kim, Jae Hyeong Park, Jae Hwan Lee, Si Wan Choi, Jin Ok Jeong
Obesity and metabolic syndrome is a worldwide pandemic and associated with high cardiovascular risk. Metabolic endotoxemia (ME) is thought to be an underlying molecular mechanism. It triggers toll-like receptor 4-mediated inflammatory adipokines and causes a chronic low grade inflammatory status, which results in cardiovascular risk increase. Exercise is the best nonpharmacological treatment to improve prognosis. In this study, we examined the circulating endotoxin level in Korean obese women and investigated effects of exercise on it...
February 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/28049019/the-causal-role-of-smoking-on-the-risk-of-hip-or-knee-replacement-due-to-primary-osteoarthritis-a-mendelian-randomisation-analysis-of-the-hunt-study
#16
M B Johnsen, G Å Vie, B S Winsvold, J H Bjørngaard, B O Åsvold, M E Gabrielsen, L M Pedersen, A I Hellevik, A Langhammer, O Furnes, G B Flugsrud, F Skorpen, P R Romundstad, K Storheim, L Nordsletten, J A Zwart
OBJECTIVE: Smoking has been associated with a reduced risk of hip and knee osteoarthritis (OA) and subsequent joint replacement. The aim of the present study was to assess whether the observed association is likely to be causal. METHOD: 55,745 participants of a population-based cohort were genotyped for the rs1051730 C > T single-nucleotide polymorphism (SNP), a proxy for smoking quantity among smokers. A Mendelian randomization analysis was performed using rs1051730 as an instrument to evaluate the causal role of smoking on the risk of hip or knee replacement (combined as total joint replacement (TJR))...
January 1, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28043929/using-the-hyperinsulinemic-euglycemic-clamp-to-assess-insulin-sensitivity-at-3%C3%A2-months-following-roux-en-y-gastric-bypass-surgery-in-type-2-diabetes-patients-with-bmi-35%C3%A2-kg-m-2-in-china
#17
Lei Zhao, Liyong Zhu, Zhihong Su, Yong Liu, Pengzhou Li, Xiangwu Yang, Weizheng Li, Lingjie Tan, Xulong Sun, Shaihong Zhu
BACKGROUND: The aim of this study was to describe short-time effect of Roux-en-Y gastric bypass (RYGB) on insulin sensitivity (IS) of Chinese diabetes patients with body mass index (BMI) <35 kg/m(2) by hyperinsulinemic euglycemic clamp. MATERIALS AND METHODS: We studied 15 type 2 diabete mellitus (T2DM) patients with BMI <35 kg/m(2), who underwent laparoscopical Roux-en-Y gastric bypass (LRYGB). Hyperinsulinemic-euglycemic clamp were performed at baseline and at 3 months after LRYGB...
December 30, 2016: International Journal of Surgery
https://www.readbyqxmd.com/read/28043711/total-hip-arthroplasty-with-a-fully-hydroxyapatite-coated-stem-a-cohort-study-during-23-28-years
#18
Olav Reikerås
BACKGROUND: Long-term results of a hydroxyapatite (HA)-coated stem are sparse. We have followed a cohort of patients operated with a grit-blasted titanium stem designed for press-fit insertion and entirely plasma-sprayed with HA up to 28 years. METHODS: In the years 1988-1993, we performed 323 primary total hip arthroplasties in 276 patients (189 women). Their mean age was 48 (15-79) years. During the following years, 83 patients with 88 hips have died, and 18 patients did not attend the follow-up examination, but had no major symptoms according to telephone interviews and control examination...
December 18, 2016: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28043313/ogilvie-s-syndrome
#19
Muhammad Waqas Khan, Sanniya Khan Ghauri, Sara Shamim
Ogilvie's syndrome, also known as 'paralytic ileus of the colon', is characterised by pseudo-obstruction of the large intestine in the absence of any mechanical obstructing component; and presents as a massively distended abdomen. If left untreated, it may lead to bowel perforation or ischemia. Ogilvie's syndrome usually presents as a postsurgical complication, mainly due to the lack and/or restriction of movement coupled with a possible electrolyte imbalance. Here, we present a case of a pre-surgical 63-year lady, having a right hip fracture, who came with complaints of severe abdominal pain and distension for 4 days...
December 2016: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28043055/hip-mechanics-underlie-lower-extremity-power-training-induced-increase-in-old-adults-fast-gait-velocity-the-potsdam-gait-study-pogs
#20
Chantal M I Beijersbergen, Urs Granacher, Martijn Gäbler, Paul DeVita, Tibor Hortobágyi
BACKGROUND: Aging is associated with slowed gait and old compared with young adults generally walk with greater positive hip work (H1) and reduced positive ankle work (A2). The role of exercise interventions on old adults' gait mechanics that underlie training-induced improvements in gait velocity is unclear. We examined the effects of lower extremity power training and detraining on old adults' gait kinetics. METHODS: As part of the Potsdam Gait Study (POGS), healthy old adults completed a no-intervention control period (69...
December 21, 2016: Gait & Posture
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