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https://www.readbyqxmd.com/read/29149623/the-effect-of-surgical-approach-on-gait-mechanics-after-total-hip-arthroplasty
#1
Joseph Zeni, Kathleen Madara, Hunter Witmer, Riley Gerhardt, James Rubano
BACKGROUND: Few studies have compared the biomechanical outcomes of different surgical approaches for hip arthroplasty. The purpose of this study was to compare hip, pelvic, and trunk kinematics and kinetics between individuals who underwent a posterior or anterolateral approach. METHODS: Forty-five individuals between 40 and 80 years old underwent motion analysis during overground gait prior to hip arthroplasty and 3 months after surgery. Walking speed, hip flexion angle, hip extension angle, adduction angle and moment, trunk angle, trunk lean, and pelvis drop were compared between approaches...
November 10, 2017: Journal of Electromyography and Kinesiology
https://www.readbyqxmd.com/read/29145611/identification-of-novel-potentially-pleiotropic-variants-associated-with-osteoporosis-and-obesity-using-cfdr-method
#2
Yuan Hu, Li-Jun Tan, Xiang-Ding Chen, Zhen Liu, Shi-Shi Min, Qin Zeng, Hui Shen, Hong-Wen Deng
Context: Genome-wide association studies (GWASs) have been successful in identifying loci associated with osteoporosis and obesity. However, the findings just explain a small fraction of the total genetic variance. Objective: The aim of this study was to identify novel pleiotropic genes important in osteoporosis and obesity. Design and Setting: A pleiotropic conditional false discovery rate (cFDR) method was applied to three independent GWAS summary statistics of femoral neck bone mineral density (FN BMD), body mass index (BMI) and waist-hip ratio (WHR)...
November 14, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29145150/microrna-146a-knockdown-suppresses-the-progression-of-ankylosing-spondylitis-by-targeting-dickkopf-1
#3
Guijuan Di, Lingli Kong, Qing Zhao, Tao Ding
Ankylosing spondylitis (AS) seriously threatens healthy and life quality of patients, however, there is no extremely effective drug to cure the disease. Therefore, it is urgent to understand molecular basis in the progression of AS. MicroRNA-146a (miR-146a) has been demonstrated to be associated with the development of AS. However, its molecular mechanism has not been fully established. In this study, it is found that the expression levels of miR-146a and dickkopf 1 (DKK1) were respectively upregulated and downregulated in hip capsule tissues of AS patients...
November 13, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29145011/preparation-of-morselised-bone-for-impaction-grafting-using-a-blender-method
#4
Mark Ruddy, David P FitzPatrick, Kenneth T Stanton
Impaction bone grafting is a method of restoring bone stock to patients suffering significant bone loss due to revision total hip surgery. The procedure requires morselised bone (MB) to be impacted into the site of bone loss in order to stabilise the prosthesis with the aim of the long term resorption and reintegration of the impacted bone graft. Currently, the method for producing MB requires the use of expensive surgical bone mills or manually-intensive rongeurs that can produce a limited variety of particle sizes and may have a low throughput...
November 9, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29143300/effect-of-restraining-the-base-of-support-on-the-other-biomechanical-features-in-patients-with-cerebellar-ataxia
#5
C Conte, Mariano Serrao, L Cuius, A Ranavolo, S Conforto, F Pierelli, L Padua
This study aimed to analyze the biomechanical consequences of reducing the base of support in patients with ataxia. Specifically, we evaluated the spatio-temporal parameters, upper- and lower-body kinematics, muscle co-activation, and energy recovery and expenditure. The gaits of 13 patients were recorded using a motion analysis system in unperturbed and perturbed walking conditions. In the latter condition, patients had to walk using the same step width and speed of healthy controls. The perturbed walking condition featured reduced gait speed, step length, hip and knee range of motion, and energy recovery and increased double support duration, gait variability, trunk oscillation, and ankle joint muscle co-activation...
November 15, 2017: Cerebellum
https://www.readbyqxmd.com/read/29143112/assessment-of-the-zonal-variation-of-perfusion-parameters-in-the-femoral-head-a-3-t-dynamic-contrast-enhanced-mri-pilot-study
#6
Jean-François Budzik, Guillaume Lefebvre, Hélène Behal, Sébastien Verclytte, Pierre Hardouin, Pedro Teixeira, Anne Cotten
OBJECTIVE: The objective was to describe MR perfusion characteristics of the femoral head, with a focus on the subchondral bone. MATERIALS AND METHODS: This prospective monocentric study was approved by our local Ethics Committee. Written informed consent was obtained from all subjects. Dynamic contrast-enhanced MRI of the right hip was performed in 59 adults with suspected spondyloarthritis (32 women, 28 men). Mean age was 37.5 (±12.5) years. Regions of interest were drawn in the femoral head epiphysis, in the subchondral areas the most exposed to mechanical load (superolateral, anterosuperior, and posterior zones) and in areas less exposed to mechanical load (inferior subchondral zone and center of the femoral head)...
November 15, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/29141879/lower-limb-biomechanical-analysis-during-an-unanticipated-step-on-a-bump-reveals-specific-adaptations-of-walking-on-uneven-terrains
#7
Fausto A Panizzolo, Sangjun Lee, Taira Miyatake, Denise Martineli Rossi, Christopher Siviy, Jozefien Speeckaert, Ignacio Galiana, Conor J Walsh
Although it is clear that walking over different irregular terrain is associated with altered biomechanics, there is little understanding of how we quickly adapt to unexpected variations in terrain. This study aims to investigate which adaptive strategies humans adopt when performing an unanticipated step on an irregular surface, specifically a small bump. Nine healthy male participants walked at their preferred walking speed along a straight walkway during five conditions: four involving unanticipated bumps of two different heights, and one level walking condition...
November 15, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/29140180/the-role-of-lumbopelvic-hip-complex-stability-in-softball-throwing-mechanics
#8
Gabrielle G Gilmer, Jessica K Washington, Jeffrey Dugas, James Andrews, Gretchen D Oliver
CONTEXT: Studies have found that a 20% reduction in energy generation from the lumbopelvic-hip complex (LPHC) during overhead throws leads to a 34% increase in load on the shoulder. OBJECTIVE: The purpose of this study was to assess the effects of LPHC stability, via the single leg squat (SLS) assessment, on throwing mechanics of softball athletes. DESIGN: Prospective cohort study. SETTING: Laboratory setting. PARTICIPANTS: Fifty softball athletes (164...
November 15, 2017: Journal of Sport Rehabilitation
https://www.readbyqxmd.com/read/29137628/hypertonic-saline-for-prevention-of-delirium-in-geriatric-patients-who-underwent-hip-surgery
#9
Xi Xin, Fei Xin, Xuguang Chen, Qi Zhang, Yanan Li, Shuping Huo, Chongfu Chang, Qiujun Wang
BACKGROUND: Postoperative delirium (POD) is a common disorder in the elderly patients, and neuroinflammation is the possible underlying mechanism. This study is designed to determine whether or not hypertonic saline (HS) pre-injection can alleviate POD in aged patients. METHODS: This prospective study recruited 120 geriatric patients who underwent hip surgery. The patients were randomly divided into two groups: control group (NS group) and HS group. Patients in the NS group were pre-injected with 4 mL/kg isotonic saline, and those in the HS group were pre-injected with 4 mL/kg 7...
November 14, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29135478/contralateral-involvement-of-congenital-muscular-torticollis-and-clavicular-fracture
#10
Shin-Young Yim, Kihong Chang, Ah-Reum Ahn, Eun Ji Park, Jongwoo Kim
Congenital muscular torticollis (CMT) is known to concur with some conditions such as developmental dysplasia of the hip or brachial plexus injury, which gives us some insights for pathogenesis of CMT. While clavicular fracture is the most common fracture in newborns, little is known about concurrence of CMT and clavicular fracture. Our clinical experience led us to realize that concurrence of CMT and clavicular fracture tended to occur on the contralateral side for each other rather than the ipsilateral side...
November 10, 2017: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/29132579/the-tragically-hip-trauma-in-elderly-patients
#11
REVIEW
Katrin Hruska, Toralph Ruge
Old age is a risk factor for poor outcome in trauma patients, as a result of undertriage and the presence of occult life-threatening injuries. The mechanisms of injury for geriatric trauma differ from those in younger patients, with a much higher incidence of low-impact trauma, especially falls from a low height. Frailty is a risk factor for severe injury after minor trauma, and caring for these patients require a multidisciplinary team with both trauma and geriatric expertise. With early recognition and aggressive management, severe injuries can still be associated with good outcomes, even in very elderly patients...
February 2018: Emergency Medicine Clinics of North America
https://www.readbyqxmd.com/read/29131775/traumatic-hip-dislocation-what-the-orthopedic-surgeon-wants-to-know
#12
Jacob C Mandell, Richard A Marshall, Michael J Weaver, Mitchel B Harris, Aaron D Sodickson, Bharti Khurana
Hip dislocation is an important orthopedic emergency usually seen in young patients who have experienced high-energy trauma, often resulting in significant long-term morbidity. Rapid identification and reduction is critical, as prolonged dislocation increases the risk of developing avascular necrosis of the femoral head, and posttraumatic osteoarthritis is a common complication, even in the absence of associated fractures. Identification and timely management of hip dislocation are highly dependent on imaging, both at presentation and after attempted reduction...
November 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/29121664/does-preoperative-mechanical-prophylaxis-have-additional-effectiveness-in-preventing-postoperative-venous-thromboembolism-in-elderly-patients-with-hip-fracture-retrospective-case-control-study
#13
Ji-Hoon Nam, Dae-Hwan Kim, Je-Hyun Yoo, Ji-Hyo Hwang, Jun-Dong Chang
BACKGROUND: Elderly patients undergoing hip fracture surgery (HFS) are at increased risk of postoperative venous thromboembolism (VTE). To reduce this risk, combined postoperative mechanical and chemical thromboprophylaxis has been routinely performed after HFS in these patients. This retrospective case-control study was conducted to evaluate the additional effectiveness of preoperative mechanical thromboprophylaxis for the prevention of VTE following HFS in elderly patients. METHODS: Of 539 consecutive patients aged 70 years or older undergoing HFS, 404 (control group) did not receive preoperative mechanical thromboprophylaxis, while 135 (study group) received mechanical thromboprophylaxis using an intermittent pneumatic compression device and graduated compression stockings from the time of admission until surgery...
2017: PloS One
https://www.readbyqxmd.com/read/29118346/genome-wide-association-study-of-idiopathic-osteonecrosis-of-the-femoral-head
#14
Yuma Sakamoto, Takuaki Yamamoto, Nobuhiko Sugano, Daisuke Takahashi, Toshiyuki Watanabe, Takashi Atsumi, Junichi Nakamura, Yukiharu Hasegawa, Koichi Akashi, Ichiei Narita, Takeshi Miyamoto, Tsutomu Takeuchi, Katsunori Ikari, Koichi Amano, Atsuhiro Fujie, Toshikazu Kubo, Yoshifumi Tada, Ayumi Kaneuji, Hiroaki Nakamura, Tomoya Miyamura, Tamon Kabata, Ken Yamaji, Takahiro Okawa, Akihiro Sudo, Kenji Ohzono, Yoshiya Tanaka, Yuji Yasunaga, Shuichi Matsuda, Yuuki Imai, Masato Akiyama, Michiaki Kubo, Yoichiro Kamatani, Yukihide Iwamoto, Shiro Ikegawa
Idiopathic osteonecrosis of the femoral head (IONFH) is an ischemic disorder that causes bone necrosis of the femoral head, resulting in hip joint dysfunction. IONFH is a polygenic disease and steroid and alcohol have already known to increase its risk; however, the mechanism of IONFH remains to be elucidated. We performed a genome-wide association study using ~60,000 subjects and found two novel loci on chromosome 20q12 and 12q24. Big data analyses identified LINC01370 as a candidate susceptibility gene in the 20q12 locus...
November 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29116830/hip-strength-as-a-predictor-of-ankle-sprains-in-male-soccer-players-a-prospective-study
#15
Christopher M Powers, Navid Ghoddosi, Rachel K Straub, Khalil Khayambashi
CONTEXT:   Diminished hip-abductor strength has been suggested to increase the risk of noncontact lateral ankle sprains. OBJECTIVE:   To determine prospectively whether baseline hip-abductor strength predicts future noncontact lateral ankle sprains in competitive male soccer players. DESIGN:   Prospective cohort study. SETTING:   Athletic training facilities and various athletic fields. PATIENTS OR OTHER PARTICIPANTS:   Two hundred ten competitive male soccer players...
November 8, 2017: Journal of Athletic Training
https://www.readbyqxmd.com/read/29114631/bore-disruption-an-unusual-mechanical-failure-of-two-hip-hemiarthroplasties
#16
Federico Dettoni, Umberto Cottino, Silvia Spriano, Davide Edoardo Bonasia, Roberto Rossi
We report a case of two hemiarthroplasties (HAs) that underwent an unexpected mechanical failure. Two patients affected by femoral fractures were treated with an HA. At 5 and 7 years after surgery, they showed a breakage of the HA at the head-stem junction. We analyzed macroscopically and microscopically (by a scanning electron microscopy) the surfaces of the broken prostheses. In both cases, a fracture was detected starting at the joining point between the femoral head and the slot that receives the taper cone of the stem (the so-called bore), with the typical macroscopic and microscopic pattern of a fatigue fracture...
March 2017: Joints
https://www.readbyqxmd.com/read/29113732/oxidative-stress-in-ageing-and-disease-development-studied-by-ft-ir-spectroscopy
#17
Jane Anastassopoulou, Maria Kyriakidou, Stylianos Kyriazis, Andreas F Mavrogenis, Vasiliki Mamareli, Ioannis Mamarelis, Marianna Petra, Efthymia Malesiou, Christoforos Kotoulas, Panagiota Kolovou, Emmanouil Koutoulakis, Athina Markouizou, Theophile Theophanides
FT-IR spectroscopy was used to investigate the effect of oxidative stress and to approach the mechanism on cancer bone demineralization, aortic valve mineralization and heterotopic ossification on disease development. The FT-IR spectra obtained from paediatric, adult bone and ex vivo irradiated adult healthy bone with a dose of 20Gy were compared with those of healthy bone. The increase of band intensity changes of vasCH2,vsCH2 in the region 3000-2850cm(-1) depended on aging, the disease progression and the dose of irradiation...
November 4, 2017: Mechanisms of Ageing and Development
https://www.readbyqxmd.com/read/29111889/the-combined-effects-of-exercise-diet-and-a-multi-ingredient-dietary-supplement-on-body-composition-and-adipokine-changes-in-overweight-adults
#18
Shawn M Arent, Alan J Walker, Joseph K Pellegrino, David J Sanders, Bridget A McFadden, Tim N Ziegenfuss, Hector L Lopez
BACKGROUND: Very few weight and fat loss supplements undergo finished-product research to examine efficacy. The purpose of this study was to determine the effects of an 8-week diet and exercise program on body composition, hip and waist girth, and adipokines and evaluate whether a dietary supplement containing raspberry ketone, capsaicin, caffeine, garlic, and Citrus aurantium enhanced outcomes. METHODS: Overweight men and women completed this randomized, placebo-controlled, double-blind study...
November 7, 2017: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/29111845/pre-clinical-evaluation-of-the-mechanical-properties-of-a-low-stiffness-cement-injectable-hip-stem
#19
Ibrahim Eldesouky, Ola Harrysson, Denis J Marcellin-Little, Harvey West, Hassan El-Hofy
In total hip arthroplasty (THA), the femoral stem can be fixed with or without bone cement. Cementless stem fixation is recommended for young and active patients as it eliminates the risk of loss of fixation at the bone-cement and cement-implant interfaces. Cementless fixation, however, suffers from a relatively high early revision rate. In the current research, a novel low-stiffness hip stem was designed, fabricated and tested. The stem design provided the option to inject biodegradable bone cement that could enhance initial stem stability...
November 7, 2017: Journal of Medical Engineering & Technology
https://www.readbyqxmd.com/read/29110905/extra-articular-hip-impingement-a-review-of-the-literature
#20
N Arévalo Galeano, N Santamaría Guinea, J Gredilla Molinero, M Grande Bárez
Hip and groin pain is a common clinical problem. Multiple causes can generate hip or groin pain, often sharing clinical and demographic characteristics. Diagnostic imaging tests play an important role in the etiological diagnosis. New forms of extra-articular hip impingement have recently been recognized as a cause of hip pain and limited function especially in young active patients. These conditions include ischiofemoral impingement, anterior inferior iliac spine and subspine impingement, iliopsoas impingement and greater trochanteric-pelvic impingement...
October 27, 2017: Radiología
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