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Cognitive disorder biomarker in blood

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https://www.readbyqxmd.com/read/29764522/treatment-resistant-depression-and-peripheral-c-reactive-protein
#1
Samuel R Chamberlain, Jonathan Cavanagh, Peter de Boer, Valeria Mondelli, Declan N C Jones, Wayne C Drevets, Philip J Cowen, Neil A Harrison, Linda Pointon, Carmine M Pariante, Edward T Bullmore
BACKGROUND: C-reactive protein (CRP) is a candidate biomarker for major depressive disorder (MDD), but it is unclear how peripheral CRP levels relate to the heterogeneous clinical phenotypes of the disorder.AimTo explore CRP in MDD and its phenotypic associations. METHOD: We recruited 102 treatment-resistant patients with MDD currently experiencing depression, 48 treatment-responsive patients with MDD not currently experiencing depression, 48 patients with depression who were not receiving medication and 54 healthy volunteers...
May 16, 2018: British Journal of Psychiatry: the Journal of Mental Science
https://www.readbyqxmd.com/read/29726891/understanding-the-role-of-the-perivascular-space-in-cerebral-small-vessel-disease
#2
Rosalind Brown, Helene Benveniste, Sandra E Black, Serge Charpak, Martin Dichgans, Anne Joutel, Maiken Nedergaard, Kenneth J Smith, Berislav V Zlokovic, Joanna M Wardlaw
Small vessel diseases are a group of disorders that result from pathological alteration of the small blood vessels in the brain, including the small arteries, capillaries and veins. Of the 35-36 million people that are estimated to suffer from dementia worldwide, up to 65% have an SVD component. Furthermore, SVD causes 20-25% of strokes, worsens outcome after stroke and is a leading cause of disability, cognitive impairment and poor mobility. Yet the underlying cause(s) of SVD are not fully understood.Magnetic resonance imaging (MRI) has confirmed enlarged perivascular spaces (PVS) as a hallmark feature of SVD...
May 2, 2018: Cardiovascular Research
https://www.readbyqxmd.com/read/29696220/evaluating-the-efficacy-of-an-integrated-motivational-interviewing-and-multi-modal-exercise-intervention-for-youth-with-major-depression-healthy-body-healthy-mind-randomised-controlled-trial-protocol
#3
Yasmina Nasstasia, Amanda L Baker, Sean A Halpin, Leanne Hides, Terry J Lewin, Brian J Kelly, Robin Callister
Background: Recent meta-analytic reviews suggest exercise can reduce depression severity among adults with major depressive disorder (MDD); however, efficacy studies with depressed youth are limited. Few studies have investigated the efficacy of multi-modal exercise interventions in this population, addressed treatment engagement, or explored the differential effects of exercise on depressive symptom profiles. Objectives: This paper describes the study protocol and recruitment pattern for an assessor blinded, two-arm randomised controlled trial investigating the efficacy of an integrated motivational interviewing (MI) and multi-modal exercise intervention in youth diagnosed with MDD...
March 2018: Contemporary Clinical Trials Communications
https://www.readbyqxmd.com/read/29673379/erythropoietin-as-an-add-on-treatment-for-cognitive-side-effects-of-electroconvulsive-therapy-a-study-protocol-for-a-randomized-controlled-trial
#4
Lejla Sjanic Schmidt, Jeff Zarp Petersen, Maj Vinberg, Ida Hageman, Niels Vidiendal Olsen, Lars Vedel Kessing, Martin Balslev Jørgensen, Kamilla Woznica Miskowiak
BACKGROUND: Electroconvulsive therapy (ECT) is the most effective treatment for severe depression, but its use is impeded by its cognitive side effects. Novel treatments that can counteract these side effects may therefore improve current treatment strategies for depression. The present randomized trial investigates (1) whether short-term add-on treatment with erythropoietin (EPO) can reduce the cognitive side -effects of ECT and (2) whether such effects are long-lasting. Further, structural and functional magnetic resonance imaging (MRI) will be used to explore the neural underpinnings of such beneficial effects of EPO...
April 19, 2018: Trials
https://www.readbyqxmd.com/read/29652574/transcriptomic-biomarkers-for-huntington-s-disease-are-gene-expression-signatures-in-whole-blood-reliable-biomarkers
#5
Maja Zadel, Aleš Maver, Anja Kovanda, Borut Peterlin
Huntington's disease (HD) is a severe neurodegenerative disorder manifesting as progressive impairment of motor function, cognitive decline, psychiatric symptoms, and immunological and endocrine dysfunction. We explored the consistency of blood transcriptomic biomarkers in HD based on a novel Slovene patient cohort and expert review of previous studies. HumanHT-12 v4 BeadChip microarrays were performed on the whole blood samples of a cohort of 23 HD mutation carriers and 23 controls to identify differentially expressed (DE) transcripts...
April 2018: Omics: a Journal of Integrative Biology
https://www.readbyqxmd.com/read/29606187/the-serum-exosome-derived-microrna-135a-193b-and-384-were-potential-alzheimer-s-disease-biomarkers
#6
Ting Ting Yang, Chen Geng Liu, Shi Chao Gao, Yi Zhang, Pei Chang Wang
OBJECTIVE: MicroRNAs (miRs) are attractive molecules to be considered as one of the blood-based biomarkers for neurodegenerative disorders such as Alzheimer's disease (AD). The goal of this study was to explore their potential value as biomarkers for the diagnosis of AD. METHODS: The expression levels of exosomal miR-135a, -193b, and -384 in the serum from mild cognitive impairment (MCI), dementia of Alzheimer-type (DAT), Parkinson's disease with dementia (PDD), and vascular dementia (VaD) patients were measured with a real-time quantitative reverse transcriptase PCR (qRT-PCR) method...
February 2018: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/29604986/hiv-associated-neurocognitive-disorder
#7
Ruaridh Cameron Smail, Bruce James Brew
Human immunodeficiency virus (HIV)-associated neurocognitive disorder (HAND) affects roughly half the HIV-positive population. The symptoms of cognitive slowing, poor concentration, and memory problems can impact on everyday life. Its diagnosis is validated where possible by identifying deficits in two cognitive domains on neuropsychologic testing in patients either with or without symptoms. Corroborating evidence may be found on imaging, blood tests, and cerebrospinal fluid analysis, though sensitive and specific biomarkers are currently lacking...
2018: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/29562536/update-on-vascular-cognitive-impairment-associated-with-subcortical-small-vessel-disease
#8
Anders Wallin, Gustavo C Román, Margaret Esiri, Petronella Kettunen, Johan Svensson, George P Paraskevas, Elisabeth Kapaki
Subcortical small-vessel disease (SSVD) is a disorder well characterized from the clinical, imaging, and neuropathological viewpoints. SSVD is considered the most prevalent ischemic brain disorder, increasing in frequency with age. Vascular risk factors include hypertension, diabetes, hyperlipidemia, elevated homocysteine, and obstructive sleep apnea. Ischemic white matter lesions are the hallmark of SSVD; other pathological lesions include arteriolosclerosis, dilatation of perivascular spaces, venous collagenosis, cerebral amyloid angiopathy, microbleeds, microinfarcts, lacunes, and large infarcts...
2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29515434/resting-state-bold-variability-in-alzheimer-s-disease-a-marker-of-cognitive-decline-or-cerebrovascular-status
#9
Vanessa Scarapicchia, Erin L Mazerolle, John D Fisk, Lesley J Ritchie, Jodie R Gawryluk
Background: Alzheimer's disease (AD) is a neurodegenerative disorder that may benefit from early diagnosis and intervention. Therefore, there is a need to identify early biomarkers of AD using non-invasive techniques such as functional magnetic resonance imaging (fMRI). Recently, novel approaches to the analysis of resting-state fMRI data have been developed that focus on the moment-to-moment variability in the blood oxygen level dependent (BOLD) signal. The objective of the current study was to investigate BOLD variability as a novel early biomarker of AD and its associated psychophysiological correlates...
2018: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29474866/targeted-proteomic-analysis-of-cognitive-dysfunction-in-remitted-major-depressive-disorder-opportunities-of-multi-omics-approaches-towards-predictive-preventive-and-personalized-psychiatry
#10
K Oliver Schubert, David Stacey, Georgia Arentz, Scott R Clark, Tracy Air, Peter Hoffmann, Bernhard T Baune
In order to accelerate the understanding of pathophysiological mechanisms and clinical biomarker discovery and in psychiatry, approaches that integrate multiple -omics platforms are needed. We introduce a workflow that investigates a narrowly defined psychiatric phenotype, makes use of the potent and cost-effective discovery technology of gene expression microarrays, applies Weighted Gene Co-Expression Network Analysis (WGCNA) to better capture complex and polygenic traits, and finally explores gene expression findings on the proteomic level using targeted mass-spectrometry (MS) technologies...
February 21, 2018: Journal of Proteomics
https://www.readbyqxmd.com/read/29474698/antibodies-in-the-diagnosis-prognosis-and-prediction-of-psychotic-disorders
#11
Thomas A Pollak, Jonathan P Rogers, Robert G Nagele, Mark Peakman, James M Stone, Anthony S David, Philip McGuire
Blood-based biomarker discovery for psychotic disorders has yet to impact upon routine clinical practice. In physical disorders antibodies have established roles as diagnostic, prognostic and predictive (theranostic) biomarkers, particularly in disorders thought to have a substantial autoimmune or infective aetiology. Two approaches to antibody biomarker identification are distinguished: a "top-down" approach, in which antibodies to specific antigens are sought based on the known function of the antigen and its putative role in the disorder, and emerging "bottom-up" or "omics" approaches that are agnostic as to the significance of any one antigen, using high-throughput arrays to identify distinctive components of the antibody repertoire...
February 21, 2018: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/29467574/a-hydrogel-biosensor-for-high-selective-and-sensitive-detection-of-amyloid-beta-oligomers
#12
Liping Sun, Yong Zhong, Jie Gui, Xianwu Wang, Xiaorong Zhuang, Jian Weng
Background: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive cognitive and memory impairment. It is the most common neurological disease that causes dementia. Soluble amyloid-beta oligomers (AβO) in blood or cerebrospinal fluid (CSF) are the pathogenic biomarker correlated with AD. Methods: A simple electrochemical biosensor using graphene oxide/gold nanoparticles (GNPs) hydrogel electrode was developed in this study. Thiolated cellular prion protein (PrPC ) peptide probe was immobilized on GNPs of the hydrogel electrode to construct an AβO biosensor...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29452984/quantitative-cerebrovascular-pathology-in-a-community-based-cohort-of-older-adults
#13
Swati Rane, Natalie Koh, Peter Boord, Tara Madhyastha, Mary K Askren, Suman Jayadev, Brenna Cholerton, Eric Larson, Thomas J Grabowski
Cerebrovascular disease, especially small vessel pathology, is the leading comorbidity in degenerative disorders. We applied arterial spin labeling and cerebrovascular reserve (CVR) imaging to quantify small vessel disease and study its effect on cognitive symptoms in nondemented older adults from a community-based cohort. We evaluated baseline cerebral blood flow (CBF) using arterial spin labeling and percent signal change as a marker of CVR using blood-oxygen level-dependent imaging following a breath-hold stimulus...
May 2018: Neurobiology of Aging
https://www.readbyqxmd.com/read/29426824/plasma-a%C3%AE-analysis-using-magnetically-labeled-immunoassays-and-pet-18-f-florbetapir-binding-in-non-demented-patients-with-major-depressive-disorder
#14
Kuan-Yi Wu, Ing-Tsung Hsiao, Chia-Hsiang Chen, Chia-Yih Liu, Jung-Lung Hsu, Sheng-Yao Huang, Tzu-Chen Yen, Kun-Ju Lin
An increased level of brain amyloid deposition and a decreased level of cerebral spinal fluid (CSF) Aβ42 are currently considered reliable biomarkers of Alzheimer's disease (AD); however, the usefulness of plasma Aβ levels are not well-established. This study investigated the relationships between plasma Aβ levels and cerebral amyloidosis in 36 non-demented patients with major depressive disorder (MDD). All participants underwent 18 F-florbetapir PET imaging and provided a blood sample at the same time for immunomagnetic reduction assay to measure the plasma levels of Aβ40 and Aβ42...
February 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29351781/mindmap-establishing-an-integrated-database-infrastructure-for-research-in-ageing-mental-well-being-and-the-urban-environment
#15
Mariëlle A Beenackers, Dany Doiron, Isabel Fortier, J Mark Noordzij, Erica Reinhard, Emilie Courtin, Martin Bobak, Basile Chaix, Giuseppe Costa, Ulrike Dapp, Ana V Diez Roux, Martijn Huisman, Emily M Grundy, Steinar Krokstad, Pekka Martikainen, Parminder Raina, Mauricio Avendano, Frank J van Lenthe
BACKGROUND: Urbanization and ageing have important implications for public mental health and well-being. Cities pose major challenges for older citizens, but also offer opportunities to develop, test, and implement policies, services, infrastructure, and interventions that promote mental well-being. The MINDMAP project aims to identify the opportunities and challenges posed by urban environmental characteristics for the promotion and management of mental well-being and cognitive function of older individuals...
January 19, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29305855/microglia-derived-extracellular-vesicles-in-alzheimer-s-disease-a-double-edged-sword
#16
REVIEW
Teresa Trotta, Maria Antonietta Panaro, Antonia Cianciulli, Giorgio Mori, Adriana Di Benedetto, Chiara Porro
Extracellular vesicles (EVs), based on their origin or size, can be classified as apoptotic bodies, microvesicles (MVs)/microparticles (MPs), and exosomes. EVs are one of the new emerging modes of communication between cells that are providing new insights into the pathophysiology of several diseases. EVs released from activated or apoptotic cells contain specific proteins (signaling molecules, receptors, integrins, cytokines), bioactive lipids, nucleic acids (mRNA, miRNA, small non coding RNAs, DNA) from their progenitor cells...
February 2018: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29182709/the-rosas-cohort-a-prospective-longitudinal-study-of-biomarkers-for-alzheimer-s-disease-strategy-methods-and-initial-results
#17
A de Mauléon, M Soto, V Kiyasova, J Delrieu, I Guignot, S Galtier, M Lilamand, C Cantet, F Lala, N Sastre, S Andrieu, M Pueyo, P J Ousset, B Vellas
OBJECTIVE: The aims of the Research Of biomarkers in Alzheimer's diseaSe (ROSAS) study were to determine the biofluid and imaging biomarkers permitting an early diagnosis of Alzheimer's disease and better characterisation of cognitive and behavioural course of the pathology. This paper outlines the overall strategy, methodology of the study, baseline characteristics of the population and first longitudinal results from the ROSAS cohort. METHODS: Longitudinal prospective monocentric observational study performed at the Alzheimer's disease Research centre in Toulouse...
2017: Journal of Prevention of Alzheimer's Disease
https://www.readbyqxmd.com/read/29136089/nutritional-status-during-inpatient-alcohol-detoxification
#18
Marie-Astrid Gautron, Frank Questel, Michel Lejoyeux, Frank Bellivier, Florence Vorspan
Aims: As low rates of thiamine are thought to be implicated in alcohol-related cognitive disorders, we wanted to assess patients with alcohol use disorders (AUD) during detoxification for their nutritional status and test if vitamins blood levels were associated with a surrogate of cognitive impairment. Methods: We performed a retrospective chart review of medical records of 94 consecutive patients hospitalized for alcohol detoxification in a specialized addiction medicine department...
January 1, 2018: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
https://www.readbyqxmd.com/read/29111419/diagnosis-of-multiple-system-atrophy
#19
REVIEW
Jose-Alberto Palma, Lucy Norcliffe-Kaufmann, Horacio Kaufmann
Multiple system atrophy (MSA) may be difficult to distinguish clinically from other disorders, particularly in the early stages of the disease. An autonomic-only presentation can be indistinguishable from pure autonomic failure. Patients presenting with parkinsonism may be misdiagnosed as having Parkinson disease. Patients presenting with the cerebellar phenotype of MSA can mimic other adult-onset ataxias due to alcohol, chemotherapeutic agents, lead, lithium, and toluene, or vitamin E deficiency, as well as paraneoplastic, autoimmune, or genetic ataxias...
May 2018: Autonomic Neuroscience: Basic & Clinical
https://www.readbyqxmd.com/read/29111133/in-vivo-brain-plaque-and-tangle-burden-mediates-the-association-between-diastolic-blood-pressure-and-cognitive-functioning-in-nondemented-adults
#20
Florence F Roussotte, Prabha Siddarth, David A Merrill, Katherine L Narr, Linda M Ercoli, Jacqueline Martinez, Natacha D Emerson, Jorge R Barrio, Gary W Small
OBJECTIVE: Growing evidence supports an association between increased blood pressure and: (a) poor cognitive performance in older adults, and (b) various biomarkers of increased Alzheimer's disease (AD) neuropathology. The objective of this study was to determine whether systolic blood pressure (SBP) and diastolic blood pressure (DBP) were significantly associated with cognitive functioning in non-demented adults, and to examine in vivo AD pathology as a possible mediator of this association...
January 2018: American Journal of Geriatric Psychiatry
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