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https://www.readbyqxmd.com/read/29341953/lethality-among-patients-with-hiv-aids-monitored-in-the-clinic-of-infectious-diseases-in-st-george-university-hospital-plovdiv-2010-2014
#1
Mariyana V Stoycheva, Nikolay T Vatev, Vania B Georgieva, Antonina P Dineva, Maria V Atanasova, Tatiana A Popova
BACKGROUND: The introduction of complex antiretroviral therapy has resulted in signifi cant decrease in the mortality rate of HIV positive patients, but it still remains unacceptably high, especially in some groups of patients. AIM: To investigate the death rate in patients with HIV/AIDS, lethality and mortality in co-infection, and the most common causes and predictors of fatal outcome, focused on early diagnosis and appropriate therapy. MATERIALS AND METHODS: The study included 53 deceased patients with HIV/AIDS, monitored at the Clinic of Infectious Diseases in St George University Hospital, Plovdiv between 01...
December 20, 2017: Folia Medica
https://www.readbyqxmd.com/read/29338578/cannabis-use-is-associated-with-lower-odds-of-prescription-opioid-analgesic-use-among-hiv-infected-individuals-with-chronic-pain
#2
Nancy L Sohler, Joanna L Starrels, Laila Khalid, Marcus A Bachhuber, Julia H Arnsten, Shadi Nahvi, John Jost, Chinazo O Cunningham
BACKGROUND: Chronic pain is common in the United States and prescribed opioid analgesics use for noncancer pain has increased dramatically in the past two decades, possibly accounting for the current opioid addiction epidemic. Co-morbid drug use in those prescribed opioid analgesics is common, but there are few data on polysubstance use patterns. OBJECTIVE: We explored patterns of use of cigarette, alcohol, and illicit drugs in HIV-infected people with chronic pain who were prescribed opioid analgesics...
January 17, 2018: Substance Use & Misuse
https://www.readbyqxmd.com/read/29325431/persons-living-with-diagnosed-hiv-in-new%C3%A2-york-city-over-50-over-50-years-old
#3
Qiang Xia, Emily Westheimer, Rebekkah S Robbins, Lucia V Torian
Using NYC HIV surveillance data, we estimated the annual median age of persons living with diagnosed HIV (PLWDH) and the proportion of PLWDH over 50 years old in NYC between 2008 and 2015, and described the characteristics, retention in care and viral suppression status among PLWDH in NYC in 2015, by age (<50 vs. ≥50 years old). The median age of PLWDH in NYC increased from 46.4 years (interquartile range [IQR]: 39.4, 53.2) in 2008 to 50.2 years (IQR: 39.8, 57.5) in 2015, and the proportion of PLWDH over 50 years old increased from 35...
January 11, 2018: AIDS Care
https://www.readbyqxmd.com/read/29316523/gender-and-race-as-correlates-of-high-risk-sex-behaviors-among-injection-drug-users-at-risk-for-hiv-enrolled-in-the-hptn-037-study
#4
Mandy J Hill, Michael Holt, Brett Hanscom, Zhe Wang, Marylou Cardenas-Turanzas, Carl Latkin
BACKGROUND: Sexual contact has been shown to be a major mode of HIV transmission among people who inject drugs (PWID). This study examined gender and racial differences among PWID' sexual risk behaviors from the perspective of sexual scripts. METHODS: 696 PWID enrolled from Philadelphia on HPTN 037 were classified as engaging in high-risk sex behaviors if they reported having sex in the past 30 days and condomless sex with a non-primary partner, giving/receiving sex for money, or multiple partners...
January 4, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29313763/sexual-violence-and-the-risk-of-hiv-transmission-in-sexual-partners-of-male-injecting-drug-users-in-tien-du-district-bac-ninh-province-of-vietnam
#5
Do Thi Vinh, Ho Thi Hien, Nguyen Manh Tri, Do Khac Huynh
We conducted a cross-sectional study among 148 women who were regular sexual partners of male injecting drug users in Tien Du, Bac Ninh province, Vietnam to identify the rate of HIV infection and factors associated with HIV transmission among them. HIV infection rate among sexual partners was high, 11.5%. Sexual violence was prevalent, 63.5% among sexual partners; 94.1% (16/17) among those with HIV. We discovered an association between sexual violence and HIV infection. Sexual partners suffering from sexual violence caused by their regular sexual partners faced 9...
January 9, 2018: Health Care for Women International
https://www.readbyqxmd.com/read/29311552/poppers-use-and-sexual-partner-concurrency-increase-the-hiv-incidence-of-msm-a-24-month-prospective-cohort-survey-in-shenyang-china
#6
Zhen-Xing Chu, Jun-Jie Xu, Yong-Hui Zhang, Jing Zhang, Qing-Hai Hu, Ke Yun, Hong-Yi Wang, Yong-Jun Jiang, Wen-Qing Geng, Hong Shang
The use of poppers is highly prevalent in MSM, but little is known about the association between their use and HIV incidence in China. A prospective cohort study was conducted from 2011 to 2013 in MSM in Shenyang. 475(79.6%) of eligible HIV-negative MSM participated in this prospective survey and near one fourth MSM (23.4%) ever used poppers. About one-third of the participants had condomless anal intercourse, half had multiple sexual partners and 10.5% were syphilis positive. The HIV incidence densities were15...
January 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29305761/patterns-of-substance-use-and-arrest-histories-among-hospitalized-hiv-drug-users-a-latent-class-analysis
#7
Karen Shiu-Yee, Ahnalee M Brincks, Daniel J Feaster, Jemima A Frimpong, Ank Nijhawan, Raul N Mandler, Robert Schwartz, Carlos Del Rio, Lisa R Metsch
Using baseline data from the NIDA Clinical Trials Network 0049 study (Project HOPE), we performed latent class analyses (LCA) to identify discrete classes, or clusters, of people living with HIV (PLWH) based on their past year substance use behaviors and lifetime arrest history. We also performed multinomial logistic regressions to identify key characteristics associated with class membership. We identified 5 classes of substance users (minimal drug users, cocaine users, substantial cocaine/hazardous alcohol users, problem polysubstance users, substantial cocaine/heroin users) and 3 classes of arrest history (minimal arrests, non-drug arrests, drug-related arrests)...
January 5, 2018: AIDS and Behavior
https://www.readbyqxmd.com/read/29299210/cost-effectiveness-of-methadone-maintenance-treatment-centers-in-prevention-of-human-immunodeficiency-virus-infection
#8
Sirus Pourkhajoei, Mohsen Barouni, Alireza Noroozi, Ahmad Hajebi, Saeed Amini, Mohammad Karamouzian, Hamid Sharifi
Background: Acquired immune deficiency syndrome (AIDS) is one of the greatest social health problems in many communities in the twenty-first century. Methadone maintenance treatment (MMT) could decrease HIV infection among injection drug users (IDU). The main aim of this paper was to determine the cost-effectiveness of the governmental MMT program to prevent human immunodeficiency virus (HIV) infection among IDU. Methods: This analytical study was performed through a before-after assessment during a one-year period...
April 2017: Addiction & Health
https://www.readbyqxmd.com/read/29294583/-studies-on-behavior-change-and-related-factors-among-female-sex-workers-in-qingdao-city-of-shandong-province-between-2006-and-2015
#9
M Z Liao, X Y Zhu, P X Huang, Z X Jiang, X J Zhang, N Zhang, G Y Wang, Y S Qian, X R Tao, D M Kang
Objective: This study aimed to analyze the behavior change and related factors regarding HIV/STD epidemics among female sex workers (FSWs) in Qingdao city. Methods: According to the requirements set by the"National HIV/AIDS sentinel surveillance program", information on demographics, sexual and drug use behaviors, and HIV-related services among female sex workers (FSWs) was collected from ten consecutive annual cross-sectional surveys from 2006 to 2015. Blood samples were drawn for serological tests on both HIV and syphilis antibodies...
December 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/29294581/-incidence-rates-of-hiv-1-epidemics-among-4-high-risk-groups-in-sichuan-province-during-2011-2015
#10
H Yang, L Su, L Ye, L Xiao, Y Hu, M G Shen, D B Wei, D Yuan, G S Zhou, H L Liu, J Yu, S Liang
Objective: Data from the HIV/AIDS surveillance sentinel sites was used to identify the recent HIV-1 infections and to estimate the HIV-1 incidence and epidemic trends among intravenous drug users (IDU), MSM, female sex workers and men attending the sexually transmitted disease clinics in Sichuan province. Methods: Specimens collected from IDUs, MSM, female sex workers and men attending the sexually transmitted disease clinics sentinel sites were confirmed as HIV-1 positive and tested with BED-CEIA. Annual HIV-1 prevalence and incidence rates were calculated and the incidence was adjusted by McNermar method...
December 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/29284807/a-clinical-study-of-opioid-substitution-therapy-in-a-tertiary-care-center-of-eastern-india
#11
Satyakam Mohapatra, Mihir Ranjan Nayak, Manaswini Dash
Background: Opioid substitution therapy (OST) is an evidence-based intervention for opiate-dependent persons that replaces illicit drug use with medically prescribed, orally administered opiates such as buprenorphine and methadone. OST reduces HIV risk behaviors and harms associated with injecting opioid. Most of the evidence for OST effectiveness has been generated in middle- and high-income countries where programs are mostly located in dedicated health-care settings; evidence regarding the outcomes of OST programs in low-income countries where OST is often provided in grassroots settings such as drop-in centers is limited...
November 2017: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/29283390/genotypic-and-phylogenetic-insights-on-prevention-of-the-spread-of-hiv-1-and-drug-resistance-in-real-world-settings
#12
REVIEW
Bluma G Brenner, Ruxandra-Ilinca Ibanescu, Isabelle Hardy, Michel Roger
HIV continues to spread among vulnerable heterosexual (HET), Men-having-Sex with Men (MSM) and intravenous drug user (IDU) populations, influenced by a complex array of biological, behavioral and societal factors. Phylogenetics analyses of large sequence datasets from national drug resistance testing programs reveal the evolutionary interrelationships of viral strains implicated in the dynamic spread of HIV in different regional settings. Viral phylogenetics can be combined with demographic and behavioral information to gain insights on epidemiological processes shaping transmission networks at the population-level...
December 28, 2017: Viruses
https://www.readbyqxmd.com/read/29278542/potential-kidney-toxicity-from-the-antiviral-drug-tenofovir-new-indications-new-formulations-and-a-new-prodrug
#13
Lili Chan, Benjamin Asriel, Ellen F Eaton, Christina M Wyatt
PURPOSE OF REVIEW: The antiviral agent tenofovir is highly effective for the treatment of HIV and hepatitis B virus infections, and the older prodrug tenofovir disoproxil fumarate (TDF) is also a component of daily preexposure prophylaxis (PrEP) to reduce the risk of HIV infection in high-risk populations. Although TDF is well tolerated, the potential for kidney and bone toxicity has important implications for public health given the large number of individuals exposed to TDF worldwide...
December 22, 2017: Current Opinion in Nephrology and Hypertension
https://www.readbyqxmd.com/read/29261438/anticipated-suicidal-ideation-among-female-injecting-drug-users-who-are-sex-workers-of-negative-or-unknown-hiv-status-in-china
#14
Joseph T F Lau, Jing Gu, Hi Yi Tsui, Hongyao Chen, Zixin Wang, Wangnan Cao
In China, female injection drug users who are also sex workers (IDUFSW) have a high prevalence of HIV and low prevalence of HIV testing. They are concerned about HIV infection and may be subjected to the risk of suicidal ideation if they become infected, due to stress and discrimination. During 2005-2006, we recruited 199 IDUFSW who self-reported negative/unknown HIV sero-status in Dazhou, Sichuan, China, to investigate the prevalence of and factors associated with suicidal ideation if they became HIV positive...
December 20, 2017: Women & Health
https://www.readbyqxmd.com/read/29260745/-molecular-epidemiological-analysis-of-hiv-1-variants-circulating-in-russia-in-1987-2015
#15
I A Lapovok, A E Lopatukhin, D E Kireev, E V Kazennova, A V Lebedev, M R Bobkova, A N Kolomeets, G I Turbina, G A Shipulin, N N Ladnaya, V V Pokrovsky
AIM: To simultaneously analyze HIV-1 samples from all Russian regions to characterize the epidemiology of HIV infection in the country as a whole. SUBJECTS AND METHODS: The most extensive study was conducted to examine nucleotide sequences of the pol gene of HIV-1 samples isolated from HIV-positive persons in different regions of Russia, with the diagnosis date being fixed during 1987-2015. The nucleotide sequences of the HIV-1 genome were analyzed using computer programs and on-line applications to identify a virus subtype and new recombinant forms...
2017: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/29258350/linkage-to-hiv-care-and-its-determinants-in-the-late-haart-era-a-systematic-review-and-meta-analysis
#16
Julian Perelman, Ricardo Rosado, Adriana Ferro, Pedro Aguiar
Poor engagement into HIV care limits the effectiveness of highly active antiretroviral therapies (HAART) to improve survival and reduce transmission. The design of effective interventions to enhance linkage to care is dependent on evidence about rates of entry into HIV care. This is a systematic review and meta-analysis on linkage measurement and its determinants in the late era of HAART (post-2003), in high-income countries. We searched the PubMed and Web of Science databases, restricting our sample to the late HAART era (post-2003) until February 2016, and to high-income countries...
December 19, 2017: AIDS Care
https://www.readbyqxmd.com/read/29258320/characterization-of-a-novel-hiv-1-circulating-recombinant-form-crf01_ae-b-c-crf96_cpx-in-yunnan-china
#17
Jing Miao, Jieyu Ran, Yindi Song, Yang Liu, Li Gao, Zhijiang Miao, Chunyue Zhang, Yue Feng, Xueshan Xia
Currently, complex HIV-1 recombination among the B', C, and CRF01_AE genotypes have frequently arisen in Yunnan, China. A novel HIV-1 complex circulating recombinant form (CRF) consisting of B', C, and CRF01_AE (CRF96_cpx) was recently characterized from three epidemiologically unlinked individuals. Two strains of them were isolated from the injecting drug users in this study, the remaining one strain (JL. RL01) obtained from a previous report in Jilin province. Phylogenetic analysis based on near full-length genome (NFLG) revealed that CRF96_cpx formed a distinct monophyletic cluster supported by a high bootstrap value of 100%, distantly related to all known HIV-1 subtypes/CRFs...
December 19, 2017: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/29249202/modeling-hiv-hcv-coinfection-epidemiology-in-the-direct-acting-antiviral-era-the-road-to-elimination
#18
Victor Virlogeux, Fabien Zoulim, Pascal Pugliese, Isabelle Poizot-Martin, Marc-Antoine Valantin, Lise Cuzin, Jacques Reynes, Eric Billaud, Thomas Huleux, Firouze Bani-Sadr, David Rey, Anne Frésard, Christine Jacomet, Claudine Duvivier, Antoine Cheret, Laurent Hustache-Mathieu, Bruno Hoen, André Cabié, Laurent Cotte
BACKGROUND: HCV treatment uptake has drastically increased in HIV-HCV coinfected patients in France since direct-acting antiviral (DAA) treatment approval, resulting in HCV cure in 63% of all HIV-HCV patients by the end of 2015. We investigated the impact of scaling-up DAA on HCV prevalence in the whole HIV population and in various risk groups over the next 10 years in France using a transmission dynamic compartmental model. METHODS: The model was based on epidemiological data from the French Dat'AIDS cohort...
December 18, 2017: BMC Medicine
https://www.readbyqxmd.com/read/29238510/epidemiology-transmission-diagnosis-and-outcome-of-hepatitis-c-virus-infection
#19
REVIEW
Seyed Hamid Moosavy, Parivash Davoodian, Mirza Ali Nazarnezhad, Abdolazim Nejatizaheh, Ebrahim Eftekhar, Hamidreza Mahboobi
Hepatitis C infection is one of the main causes of chronic liver disorders worldwide. Nearly three percent (3%) of the world population has an HCV infection. Prevalence of HCV infection was higher in some groups such as injected drug users (IDUs) and HIV positive populations. Acute hepatitis has proven asymptomatic in most cases, and delay of diagnosis might lead to late onset of hepatocellular carcinoma and cirrhosis. Some host characteristics such as age, gender, body mass index, and viral properties are associated with HCV outcome hepatitis...
October 2017: Electronic Physician
https://www.readbyqxmd.com/read/29238237/adolescent-pre-exposure-prophylaxis-for-hiv-prevention-current-perspectives
#20
REVIEW
Daisy Maria Machado, Alexandre Machado de Sant'Anna Carvalho, Rachel Riera
Adolescents are a critical population that is disproportionately impacted by the HIV epidemic. More than 2 million adolescents between the age group of 10 and 19 years are living with HIV, and millions are at risk of infection. HIV risks are considerably higher among girls, especially in high-prevalence settings such as eastern and southern Africa. In addition to girls, there are other vulnerable adolescent subgroups, such as teenagers, who use intravenous (IV) drugs, gay and bisexual boys, transgender youth, male sex workers, and people who fall into more than one of these categories...
2017: Adolescent Health, Medicine and Therapeutics
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