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claudin gene regulation

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https://www.readbyqxmd.com/read/29337896/caffeic-acid-and-metformin-inhibit-invasive-phenotype-induced-by-tgf-%C3%AE-1-in-c-4i-and-htb-35-siha-human-cervical-squamous-carcinoma-cells-by-acting-on-different-molecular-targets
#1
Malgorzata Tyszka-Czochara, Malgorzata Lasota, Marcin Majka
During the progression of epithelial cancer, the cells may lose epithelial markers and gain mesenchymal phenotype via Epithelial-Mesenchymal Transition (EMT). Such transformation of epithelial cancer cells to mesenchymal-like characteristic benefits plasticity and supports their ability to migrate. The aim of this study was to evaluate the influence of natural compound Caffeic Acid (CA) alone and in combination with antidiabetic drug Metformin (Met) on metastatic progression of two human cervical squamous cell cancer lines, C-4I and HTB-35/SiHa cells...
January 16, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29319048/analysis-of-differential-expression-of-tight-junction-proteins-in-cultured-oral-epithelial-cells-altered-by-porphyromonas-gingivalis-porphyromonas-gingivalis-lipopolysaccharide-and-extracellular-adenosine-triphosphate
#2
Wei Guo, Peng Wang, Zhong-Hao Liu, Ping Ye
Tight junctions (TJs) are the most apical intercellular junctions of epithelial cells formed by occludin, claudins, junctional adhesion molecules (JAMs), and zonula occludens (ZO). Tight junction proteins can sense the presence of bacteria and regulate the transcription of target genes that encode effectors and regulators of the immune response. The aim of this study was to determine the impact of TJ proteins in response to Porphyromonas gingivalis (P. gingivalis), P. gingivalis lipopolysaccharide (P. gingivalis LPS), and extracellular adenosine triphosphate (ATP) in the oral epithelial cell culture model...
January 10, 2018: International Journal of Oral Science
https://www.readbyqxmd.com/read/29276042/intestinal-tight-junctions-are-severely-altered-in-nec-preterm-neonates
#3
Amir Bein, Smadar Eventov-Friedman, Dan Arbell, Betty Schwartz
BACKGROUND & AIMS: Necrotizing Enterocolitis (NEC) is a severe inflammatory disorder of the intestine endangering the health and survival of preterm infants. It is well established that the gut barrier is severely damaged in NEC patients, nonetheless an in depth investigation of modifications at the transcriptional and translational levels of tight junction genes and proteins during NEC are still missing. The aim of this study was to investigate changes in the expression of tight junctions and other associated proteins during NEC and determine their correlation to the disease severity...
December 7, 2017: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/29258755/effects-of-dietary-dandelion-extract-on-intestinal-morphology-antioxidant-status-immune-function-and-physical-barrier-function-of-juvenile-golden-pompano-trachinotus-ovatus
#4
Xiaohong Tan, Zhenzhu Sun, Chuanpeng Zhou, Zhong Huang, Lianjie Tan, Pengwei Xun, Qianqian Huang, Heizhao Lin, Chaoxia Ye, Anli Wang
Intestinal morphology, antioxidant status, immune function and tight junction proteins mRNA expression were examined in golden pompano (Trachinotus ovatus) that fed respectively six diets containing dandelion extracts (DE) at 0, 0.5, 1, 2, 4 and 10 g kg-1 after 8 weeks feeding. The study indicated that dietary DE significantly improved intestinal antioxidant abilities by increasing SOD, CAT, T-AOC activities and up-regulating intestinal cat, gpx mRNA levels, but by decreasing MDA content and down-regulating intestinal keap1 mRNA levels in golden pompano...
December 16, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29233846/ve-cadherin-mediated-epigenetic-regulation-of-endothelial-gene-expression
#5
Marco F Morini, Costanza Giampietro, Monica Corada, Federica Pisati, Elisa Lavarone, Sara I Cunha, Lei L Conze, Nicola J O'Reilly, Dhira Joshi, Svend Kjaer, Roger George, Emma Nye, Anqi Ma, Jian Jin, Richard Mitter, Michela Lupia, Ugo Cavallaro, Diego Pasini, Dinis P Calado, Elisabetta Dejana, Andrea Taddei
Rationale: The mechanistic foundation of vascular maturation is still largely unknown. Several human pathologies are characterized by deregulated angiogenesis and unstable blood vessels. Solid tumours, for instance, get their nourishment from newly formed structurally abnormal vessels which present wide and irregular inter-endothelial junctions. Expression and clustering of the main endothelial-specific adherens junction protein, vascular endothelial (VE)-cadherin (VEC), upregulate genes with key roles in endothelial differentiation and stability...
December 12, 2017: Circulation Research
https://www.readbyqxmd.com/read/29229758/the-stress-sigma-factor-of-rna-polymerase-rpos-%C3%AF-s-is-a-solvent-exposed-open-molecule-in-solution
#6
Paola Cavaliere, Sébastien Brier, Petr Filipenko, Christina Sizun, Bertrand Raynal, Françoise Bonneté, Fabienne Levi-Acobas, Jacques Bellalou, Patrick England, Julia Chamot-Rooke, Claudine Mayer, Françoise Norel
In bacteria, one primary and multiple alternative σ factors associate with the RNA polymerase core enzyme (E) to form holoenzymes (Eσ) with different promoter recognition specificities. The alternative σ factor RpoS/σS is produced in stationary phase and under stress conditions and reprograms global gene expression to promote bacterial survival. To date, the three-dimensional structure of a full-length free σ factor remains elusive. The current model suggests that extensive interdomain contacts in a free σ factor result in a compact conformation that masks the DNA-binding determinants of σ, explaining why a free σ factor does not bind double stranded promoter DNA efficiently...
December 11, 2017: Biochemical Journal
https://www.readbyqxmd.com/read/29217457/focusing-on-claudin-5-a-promising-candidate-in-the-regulation-of-bbb-to-treat-ischemic-stroke
#7
REVIEW
Jianjun Lv, Wei Hu, Zhi Yang, Tian Li, Shuai Jiang, Zhiqiang Ma, Fulin Chen, Yang Yang
Claudin-5 is a tight junction (TJ) protein in the blood-brain barrier (BBB) that has recently attracted increased attention. Numerous studies have demonstrated that claudin-5 regulates the integrity and permeability of the BBB. Increased claudin-5 expression plays a neuroprotective role in neurological diseases, particularly in cerebral ischemic stroke. Moreover, claudin-5 might be a potential marker for early hemorrhagic transformation detection in ischemic stroke. In light of the distinctive effects of claudin-5 on the nervous system, we present the elaborate network of roles that claudin-5 plays in ischemic stroke...
December 5, 2017: Progress in Neurobiology
https://www.readbyqxmd.com/read/29214215/genomic-and-transcriptomic-heterogeneity-in-metaplastic-carcinomas-of-the-breast
#8
Salvatore Piscuoglio, Charlotte K Y Ng, Felipe C Geyer, Kathleen A Burke, Catherine F Cowell, Luciano G Martelotto, Rachael Natrajan, Tatiana Popova, Christopher A Maher, Raymond S Lim, Ino de Bruijn, Odette Mariani, Larry Norton, Anne Vincent-Salomon, Britta Weigelt, Jorge S Reis-Filho
Metaplastic breast cancer (MBC) is a rare special histologic type of triple-negative breast cancer, characterized by the presence of neoplastic cells showing differentiation towards squamous epithelium and/or mesenchymal elements. Here we sought to define whether histologically distinct subgroups of MBCs would be underpinned by distinct genomic and/or transcriptomic alterations. Microarray-based copy number profiling identified limited but significant differences between the distinct MBC subtypes studied here, despite the limited sample size (n = 17)...
2017: NPJ Breast Cancer
https://www.readbyqxmd.com/read/29203829/il-4-driven-transcription-factor-foxq1-is-expressed-by-monocytes-in-atopic-dermatitis-and-stimulates-monocyte-migration
#9
Ilja Ovsiy, Vladimir Riabov, Ioannis Manousaridis, Julia Michel, Kondaiah Moganti, Shuiping Yin, Tengfei Liu, Carsten Sticht, Elisabeth Kremmer, Martin C Harmsen, Sergij Goerdt, Alexei Gratchev, Julia Kzhyshkowska
Monocytes are actively recruited at sites of chronic inflammation. However, molecular factors involved in this process are not fully elucidated. Here, we show that cytokine IL-4 which is implicated in the development of chronic inflammatory disease atopic dermatitis (AD) induces expression of transcription factor FoxQ1 in human monocytes and macrophages. FoxQ1 mRNA levels were elevated in monocytes of AD patients compared to healthy donors. Overexpression of FoxQ1 in RAW 264.7 monocytic cells facilitated their migration towards MCP-1 and was associated with decreased expression of migration-regulating genes (claudin 11 and plexin C1)...
December 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29203393/pyrin-inflammasome-regulates-tight-junction-integrity-to-restrict-colitis-and-tumorigenesis
#10
Deepika Sharma, Ankit Malik, Clifford S Guy, Rajendra Karki, Peter Vogel, Thirumala-Devi Kanneganti
BACKGROUND & AIMS: Inflammatory bowel diseases (IBD) increase risk for colorectal cancer. Mutations in the Mediterranean fever gene (MEFV or pyrin) are associated with hereditary autoinflammatory disease and severe IBD. Expression of MEFV, a sensor protein that the initiates assembly of the inflammasome complex, is increased in colon biopsies from patients with IBD. We investigated the role of pyrin in intestinal homeostasis in mice. METHODS: Mefv-/- mice and C57/BL6 mice (controls) were given azoxymethane followed by multiple rounds of dextran sodium sulfate (DSS) to induce colitis and tumorigenesis...
December 1, 2017: Gastroenterology
https://www.readbyqxmd.com/read/29197120/resveratrol-inhibits-obesity-associated-adipose-tissue-dysfunction-and-tumor-growth-in-a-mouse-model-of-postmenopausal-claudin-low-breast-cancer
#11
Emily L Rossi, Subreen A Khatib, Steven S Doerstling, Laura W Bowers, Melissa Pruski, Nikki A Ford, Randolph D Glickman, Mengmeng Niu, Peiying Yang, Zhengrong Cui, John DiGiovanni, Stephen D Hursting
Adipose tissue dysregulation, a hallmark of obesity, contributes to a chronic state of low-grade inflammation and is associated with increased risk and progression of several breast cancer subtypes, including claudin-low breast tumors. Unfortunately, mechanistic targets for breaking the links between obesity-associated adipose tissue dysfunction, inflammation, and claudin-low breast cancer growth have not been elucidated. Ovariectomized female C57BL/6 mice were randomized (n = 15/group) to receive a control diet, a diet-induced obesity (DIO) diet, or a DIO + resveratrol (0...
November 20, 2017: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/29173301/targeted-gene-next-generation-sequencing-in-chinese-children-with-chronic-pancreatitis-and-acute-recurrent-pancreatitis
#12
Yuan Xiao, Wentao Yuan, Bo Yu, Yan Guo, Xu Xu, Xinqiong Wang, Yi Yu, Yi Yu, Biao Gong, Chundi Xu
OBJECTIVE: To identify causal mutations in certain genes in children with acute recurrent pancreatitis (ARP) or chronic pancreatitis (CP). STUDY DESIGN: After patients were enrolled (CP, 55; ARP, 14) and their clinical characteristics were investigated, we performed next-generation sequencing to detect nucleotide variations among the following 10 genes: cationic trypsinogen protease serine 1 (PRSS1), serine protease inhibitor, Kazal type 1 (SPINK1), cystic fibrosis transmembrane conductance regulator gene (CFTR), chymotrypsin C (CTRC), calcium-sensing receptor (CASR), cathepsin B (CTSB), keratin 8 (KRT8), CLAUDIN 2 (CLDN2), carboxypeptidase A1 (CPA1), and ATPase type 8B member 1 (ATP8B1)...
December 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/29152115/hdac-4-regulates-claudin-2-expression-in-egfr-erk1-2-dependent-manner-to-regulate-colonic-epithelial-cell-differentiation
#13
Rizwan Ahmad, Balawant Kumar, Kaichao Pan, Punita Dhawan, Amar B Singh
In normal colon, claudin-2 expression is restricted to the crypt bottom containing the undifferentiated and proliferative colonocytes. Claudin-2 expression is also upregulated in colorectal cancer (CRC) and promotes carcinogenesis. However, cellular mechanism/s regulated by increased claudin-2 expression during the CRC and mechanism/s regulating this increase remain poorly understood. Epigenetic mechanisms help regulate expression of cancer-associated genes and inhibition of Histone Deacetylases (HDACs) induces cell cycle arrest and differentiation...
October 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/29150498/identification-of-a-chez-like-gene-in-azorhizobium-caulinodans-a-key-gene-in-the-control-of-chemotaxis-and-colonization-of-the-host-plant
#14
Xiaolin Liu, Wei Liu, Yu Sun, Chunlei Xia, Claudine Elmerich, Zhihong Xie
Chemotaxis can provide bacteria with competitive advantages for survival in complex environments. The CheZ chemotaxis protein is a phosphatase, affecting the flagellar motor in Escherichia coli, by dephosphorylating the response regulator CheY-P protein responsible for clockwise rotation. A cheZ gene has been found in Azorhizobium caulinodans ORS571, in contrast to other rhizobial species studied so far. The CheZ protein in ORS571 has a conserved motif similar to that corresponding to the phosphatase active site in E...
November 17, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29145406/the-axis-il-10-claudin-10-is-implicated-in-the-modulation-of-aggressiveness-of-melanoma-cells-by-b-1-lymphocytes
#15
Elizabeth Cristina Perez, Patricia Xander, Maria Fernanda Lucatelli Laurindo, Ronni Rômulo Novaes E Brito, Bruno Camolese Vivanco, Renato Arruda Mortara, Mario Mariano, José Daniel Lopes, Alexandre Castro Keller
B-1 lymphocytes are known to increase the metastatic potential of B16F10 melanoma cells via the extracellular signal-regulated kinase (ERK) pathway. Since IL-10 is associated with B-1 cells performance, we hypothesized that IL-10 could be implicated in the progression of melanoma. In the present work, we found that the C57BL/6 mice, inoculated with B16F10 cells that were co-cultivated with B-1 lymphocytes from IL-10 knockout mice, developed fewer metastatic nodules than the ones which were injected with the melanoma cells that were cultivated in the presence of wild-type B-1 cells...
2017: PloS One
https://www.readbyqxmd.com/read/29107696/the-potential-mechanism-for-hydroxysafflor-yellow-a-attenuating-blood-brain-barrier-dysfunction-via-tight-junction-signaling-pathways-excavated-by-an-integrated-serial-affinity-chromatography-and-shotgun-proteomics-analysis-approach
#16
Yanni Lv, Longsheng Fu
Our previous studies elucidated that hydroxysafflor yellow A (HSYA) exerted anti-inflammatory effects against ischemia stroke by inhibiting TLR4 pathway-mediated signaling transduction. However, only several targets were verified in that limited work. The integrated method of serial affinity chromatography (SAC) and shotgun proteomics analysis (SPA) might be an alternative approach for exploring a potential therapeutic role. SAC was induced to extract specific binding proteins in the brain tissue of 2 h of ischemia stroke mice via HSYA affinity matrices...
October 28, 2017: Neurochemistry International
https://www.readbyqxmd.com/read/29039479/mdig-suppresses-epithelial-mesenchymal-transition-and-inhibits-the-invasion-and-metastasis-of-non%C3%A2-small-cell-lung-cancer-via-regulating-gsk-3%C3%AE-%C3%AE-catenin-signaling
#17
Feng Geng, Zhanshi Jiang, Xiaogang Song, Haomin Zhou, Hongwen Zhao
Mineral dust-induced gene (mdig) can inhibit the invasion and metastasis of A549 cells. The main purpose of this study was to explore the molecular mechanism underlying the inhibitory effect of mdig on cell invasion and metastasis. Mdig-knockdown and mdig-overexpressing A549 cells and an mdig-overexpressing human umbilical vein endothelial cell (HUVEC) line were constructed using lentiviral vectors, and western blot analysis was performed to verify the silencing and overexpression of the mdig protein. A Transwell invasion assay was used to detect the invasive abilities of each experimental group, and Transwell migration and scratch assays were used to detect cell migration ability...
October 12, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28987542/establishment-of-twist-1-and-tgfbr2-as-direct-targets-of-microrna-20a-in-mesenchymal-to-epithelial-transition-of-breast-cancer-cell-line-mda-mb-231
#18
Soumasree De, Sayantani Das, Srimoyee Mukherjee, Sainy Das, Sumita Sengupta Bandyopadhyay
Messenchymal to epithelial transition (MET) is a significant physiological phenomenon involved in embryogenesis and cancer. This study aims at investigating the mechanism of microRNA-20a (miR-20a) mediated regulation of mesenchymal to epithelial transition and identification of its direct target genes in breast cancer cell-line, MDA-MB-231. Reduced migratory and invasive property, altered cellular morphology along with reduced capability for attachment to basement membrane was acquired by over-expression of miR-20a in invasive MDA-MB-231 cell-line initially expressing low level of this micro-RNA, indicating direct correlation between abundance of miR-20a and metastatic property...
October 5, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28978116/modulation-of-dkk-3-and-claudin-5-as-new-therapeutic-strategy-in-the-treatment-of-meningiomas
#19
Maria Caffo, Emanuela Esposito, Valeria Barresi, Gerardo Caruso, Salvatore M Cardali, Mariagrazia Rinaldi, Raffaella Mallamace, Michela Campolo, Giovanna Casili, Alfredo Conti, Antonino Germanò, Salvatore Cuzzocrea, Letteria Minutoli
Meningiomas are the most common tumors of the central nervous system, where the incidence is around 25% of all primary brain tumors. The optimal treatment is represented by total resection accompanied by the removal of the dura mater and bone when infiltrated by the tumor. The histological grading is the most important prognostic factor in the outcome. However, recurrences do occur in a significant proportion (10-25%) of cases, representing the most relevant clinical complication. Molecular therapies are providing to give different opportunities in the development of new treatments...
September 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28961379/claudin-5-regulates-blood-brain-barrier-permeability-by-modifying-brain-microvascular-endothelial-cell-proliferation-migration-and-adhesion-to-prevent-lung-cancer-metastasis
#20
Shun-Chang Ma, Qi Li, Jia-Yi Peng, Jian-Long Zhouwen, Jin-Fu Diao, Jian-Xing Niu, Xi Wang, Xiu-Dong Guan, Wang Jia, Wen-Guo Jiang
AIMS: To investigate the roles of Claudin-5 (CLDN5) in regulating the permeability of the blood-brain barrier (BBB) during lung cancer brain metastasis. RESULTS: By silencing and overexpressing the CLDN5 gene in human brain vascular endothelial (hCMEC/D3) cells, we demonstrated the attenuation of cell migration ability and CLDN5's significant positive role in cell proliferation in CLDN5-overexpressing hCMEC/D3 cells and observed the opposite result in the CLDN5 knockdown group...
September 29, 2017: CNS Neuroscience & Therapeutics
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