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https://www.readbyqxmd.com/read/29676341/the-prevalence-and-risk-factors-for-trichomonas-vaginalis-infection-amongst-human-immunodeficiency-virus-infected-pregnant-women-attending-the-antenatal-clinics-of-a-university-teaching-hospital-in-lagos-south-western-nigeria
#1
Olaolopin Ijasan, Kehinde Sharafadeen Okunade, Ayodeji Ayotunde Oluwole
Background: Trichomonas vaginalis infection is the most prevalent non-viral sexually transmitted infection worldwide. Interactions between this infection and human immunodeficiency virus (HIV) may cause adverse pregnancy outcomes such as preterm labour, premature rupture of membranes, chorioamnionitis, low birth weight and post-abortal sepsis. Aims: This study was aimed to determine the prevalence and risk factors of T. vaginalis infection amongst HIV-positive pregnant women attending antenatal care at the Lagos University Teaching Hospital (LUTH), Lagos, Nigeria...
January 2018: Nigerian Postgraduate Medical Journal
https://www.readbyqxmd.com/read/29660492/characterization-of-multiple-enolase-ggenes-from-trichomonas-vaginalis-potential-novel-targets-for-drug-and-vaccine-design
#2
Elibeth Mirasol-Meléndez, Luis G Brieba-de Castro, Corina Díaz-Quezada, Marisol López-Hidalgo, Elisa E Figueroa-Angulo, Leticia Ávila-González, Rossana Arroyo-Verástegui, Claudia G Benítez-Cardoza
Trichomonas vaginalis is the protist parasite that causes the most common, non-viral sexually transmitted infection called trichomonosis. Enolase is a moonlighting protein that apart from its canonical function as a glycolytic enzyme, serves as a plasminogen receptor on the cell surface of T. vaginalis and, in consequence, it has been stablished as a virulence factor in this parasite. In the Trichomonas vaginalis sequence database there are nine genes annotated as enolase. In this work, we analyzed these genes as well as their products...
April 13, 2018: Parasitology International
https://www.readbyqxmd.com/read/29660412/mycoplasma-hominis-shows-strain-dependent-increase-of-resistance-to-selected-antibiotics-after-symbiosis-with-trichomonas-vaginalis
#3
Ursula Fürnkranz, Julia Walochnik, Birgit Henrich
OBJECTIVES: Mycoplasma hominis, a genetically heterogeneous, cell-wall less bacterium, is able to live in symbiosis with the protozoan parasite Trichomonas vaginalis. While impacts of this symbiosis on T. vaginalis have been investigated to a certain extent, less light has been shed on the influence on M. hominis. METHODS: In an in vitro minimal inhibitory concentration (MIC) study the antibiotic susceptibility of three clinical M. hominis isolates, V475, AKH136 and MhSS10, to clindamycin, moxifloxacin, ciprofloxacin and gentamicin was investigated in dependence on symbiosis with T...
April 13, 2018: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/29653033/organometallic-conjugates-of-the-drug-sulfadoxine-for-combatting-antimicrobial-resistance
#4
Peter J Sadler, Prinessa Chellan, Vicky Avery, Sandra Duffy, James Triccas, Gayathri Nagalingam, Christina Tam, Luisa Cheng, Jenny Liu, Kirkwood Land, Guy Clarkson, Isolda Romero
Fourteen novel arene RuII, and cyclopentadienyl (Cpx) RhIII and IrIII complexes containing an N,N'-chelated pyridylimino- or quinolylimino ligand functionalized with the antimalarial drug sulfadoxine have been synthesized and characterized, including three by x-ray crystallography. Rhodium and iridium complexes exhibited potent antiplasmodial activity with IC50 values of 0.10 - 2.0 µM in either all, or one of the three Plasmodium falciparum assays (3D7 chloroquine sensitive, Dd2 chloroquine resistant and NF54 sexual late stage gametocytes), but were only moderately active towards Trichomonas vaginalis...
April 13, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29643195/diagnostic-performance-of-a-molecular-test-versus-clinician-assessment-of-vaginitis
#5
Jane R Schwebke, Charlotte A Gaydos, Paul Nyirjesy, Sonia Paradis, Salma Kodsi, Charles K Cooper
Background: Vaginitis is a common complaint, diagnosed either empirically or using Amsel's criteria and wet mount microscopy. Objective: To determine characteristics of an investigational test (a molecular-based test for vaginitis), as compared to reference, for detection of bacterial vaginosis, Candida spp., and Trichomonas vaginalis Study Design: Vaginal specimens from a cross-sectional study were obtained from 1,740 women (≥18 years old), with vaginitis symptoms, during routine clinic visits (across 10 sites in the USA)...
April 11, 2018: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29624912/antichagasic-leishmanicidal-and-trichomonacidal-activity-of-2-benzyl-5-nitroindazole-derived-amines
#6
Vicente J Aran, Cristina Fonseca-Berzal, Alexandra Ibáñez-Escribano, Nerea Vela, José Cumella, Juan José Nogal-Ruiz, José Antonio Escario, Patrícia Bernardino da Silva, Marcos Meuser Batista, Maria de Nazaré C Soeiro, Sergio Sifontes-Rodriguez, Alfredo Meneses-Marcel, Alicia Gómez-Barrio
Three different series of new 5-nitroindazole derivatives, 1-(ω-aminoalkyl)-2-benzylindazolin-3-ones (series A; 10 compounds), 3-(ω-aminoalkoxy)-2-benzylindazoles (series B; 4 compounds) and 3-alkylamino-2-benzylindazoles (series C; 5 compounds), have been synthesized and evaluated against the protozoan parasites Trypanosoma cruzi, Leishmania amazonensis and Trichomonas vaginalis, etiological agents of Chagas disease, cutaneous leishmaniasis and trichomoniasis, respectively. Many indazoles of series A, B and C were efficient against T...
April 6, 2018: ChemMedChem
https://www.readbyqxmd.com/read/29624560/sexual-behaviors-of-hiv-infected-pregnant-women-and-factors-associated-with-sexual-transmitted-infection-in-south-africa
#7
Dvora Joseph Davey, Remco P H Peters, Noah Kojima, Maanda Mudau, Lindsey De Vos, Dawie Olivier, James A McIntyre, Jeffrey D Klausner, Andrew Medina-Marino
BACKGROUND: Sexual behaviors in HIV-infected pregnant women in South Africa are not well understood. METHODS: HIV-infected pregnant women were recruited into a prospective cohort at first antenatal care visit. Sociodemographic information and self-collected vulvovaginal swab samples were collected from participants. Vulvovaginal swab samples were tested for Chlamydia trachomatis (CT), Neisseria gonorrhoea (NG) and Trichomonas vaginalis (TV) using GeneXpert®. We investigated sexual behaviors, alcohol use and factors associated with condomless sex during pregnancy and prevalent sexually transmitted infection (STI) among our cohort...
April 5, 2018: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/29623424/fe-s-cluster-assembly-in-the-supergroup-excavata
#8
REVIEW
Priscila Peña-Diaz, Julius Lukeš
The majority of established model organisms belong to the supergroup Opisthokonta, which includes yeasts and animals. While enlightening, this focus has neglected protists,  organisms that represent the bulk of eukaryotic diversity and are often regarded as primitive eukaryotes. One of these is the "supergroup" Excavata, which comprises unicellular flagellates of diverse lifestyles and contains species of medical importance, such as Trichomonas, Giardia, Naegleria, Trypanosoma and Leishmania. Excavata exhibits a continuum in mitochondrial forms, ranging from classical aerobic, cristae-bearing mitochondria to mitochondria-related organelles, such as hydrogenosomes and mitosomes, to the extreme case of a complete absence of the organelle...
April 5, 2018: Journal of Biological Inorganic Chemistry: JBIC
https://www.readbyqxmd.com/read/29620469/tetratrichomonas-and-trichomonas-spp-associated-disease-in-free-ranging-common-eiders-somateria-mollissima-from-wellfleet-bay-ma-and-description-of-its1-region-genotypes
#9
C Grunenwald, I Sidor, R Mickley, C Dwyer, R Gerhold
During an outbreak of Wellfleet Bay virus (WFBV) in common eiders ( Somateria mollissima) from the Cape Cod region of Massachusetts, several birds were diagnosed with trichomonosis consisting of multiple trichomonad species. Six birds were examined, with trichomonads found in ceca in four birds and associated typhlitis in three of these four birds. PCR and DNA sequencing utilizing trichomonad-specific primers targeting the ITS1 region of the ribosomal DNA (rDNA) revealed the presence of Tetratrichomonas gallinarum in the gastrointestinal tracts of five birds and Trichomonas spp...
March 2018: Avian Diseases
https://www.readbyqxmd.com/read/29619908/prevalence-of-sexually-transmitted-diseases-in-asymptomatic-renal-transplant-recipients
#10
Mehmet Sarier, Nevgun Sepin Ozen, Hicran Guler, Ibrahim Duman, Yücel Yüksel, Sabri Tekin, Asuman Havva Yavuz, Levent Yucetin, Mine Erdogan Yilmaz
OBJECTIVES: Sexually transmitted diseases, which may be asymptomatic, have the potential to cause serious health problems in renal transplant recipients. The aim of this study was to determine the prevalence of sexually transmitted diseases in sexually active asymptomatic renal transplant patients by using real-time multiplex polymerase chain reaction assays. MATERIALS AND METHODS: This prospective controlled study was conducted between November 2016 and January 2017 in our hospital...
April 4, 2018: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/29615721/structural-basis-of-interaction-between-dimeric-cyclophilin-1-and-myb1-transcription-factor-in-trichomonas-vaginalis
#11
Tesmine Martin, Yuan-Chao Lou, Chun-Chi Chou, Shu-Yi Wei, Sushant Sadotra, Chao-Cheng Cho, Meng-Hsuan Lin, Jung-Hsiang Tai, Chun-Hua Hsu, Chinpan Chen
Cyclophilin 1 (TvCyP1), a cyclophilin type peptidyl-prolyl isomerase present in the human parasite Trichomonas vaginalis, interacts with Myb1 and assists in its nuclear translocation. Myb1 regulates the expression of ap65-1 gene that encodes for a disease causing cytoadherence enzyme. Here, we determined the crystal structures of TvCyP1 and its complex with the minimum TvCyP1-binding sequence of Myb1 (Myb1104-111 ), where TvCyP1 formed a homodimer, unlike other single domain cyclophilins. In the complex structure, one Myb1104-111 peptide was bound to each TvCyP1 protomer, with G106-P107 and Y105 fitting well into the active site and auxiliary S2 pocket, respectively...
April 3, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29608771/aberrant-and-accidental-trichomonad-flagellate-infections-rare-or-underdiagnosed
#12
Chaoqun Yao, Jennifer K Ketzis
The clinical significance and frequency of human infections with trichomonad flagellates in aberrant locations (locations other than the predilection sites) and accidental infections (infections with non-human trichomonads) are unclear. The total number of case reports in the literature is low, with the identification of the infection largely the outcome of investigations for the cause of clinical signs. At least seven species have been identified in either aberrant or accidental infections, with these infections occurring worldwide...
March 28, 2018: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29589477/drug-repositioning-for-novel-antitrichomonas-from-known-antiprotozoan-drugs-using-hierarchical-screening
#13
Alfredo Meneses-Marcel, Yovani Marrero-Ponce, Alexandra Ibáñez-Escribano, Alicia Gómez-Barrio, José A Escario, Stephen J Barigye, Enrique Terán, Cesar R García-Jacas, Yanetsy Machado-Tugores, Juan J Nogal-Ruiz, Vicente J Arán-Redó
AIM: Metronidazole is the most widely used drug in trichomoniasis therapy. However, the emergence of metronidazole-resistant Trichomonas vaginalis isolates calls for the search for new drugs to counter the pathogenicity of these parasites. RESULTS: Classification models for predicting the antitrichomonas activity of molecules were built. These models were employed to screen antiprotozoal drugs, from which 20 were classified as active. The in vitro experiments showed moderate to high activity for 19 of the molecules at 10 μg/ml, while 3 compounds yielded higher activity than the reference at 1 μg/ml...
March 28, 2018: Future Medicinal Chemistry
https://www.readbyqxmd.com/read/29572567/anti-trichomonas-vaginalis-activity-of-ursolic-acid-derivative-a-promising-alternative
#14
Fernanda Gobbi Bitencourt, Patrícia de Brum Vieira, Lucia Collares Meirelles, Graziela Vargas Rigo, Elenilson Figueiredo da Silva, Simone Cristina Baggio Gnoatto, Tiana Tasca
Trichomonas vaginalis is an extracellular parasite that binds to the epithelium of the human urogenital tract and causes the sexually transmitted infection, trichomoniasis. In view of increased resistance to drugs belonging to the 5-nitroimidazole class, new treatment alternatives are urgently needed. In this study, eight semisynthetized triterpene derivatives were evaluated for in vitro anti-T. vaginalis activity. Ursolic acid and its derivative, 3-oxime-urs-12-en-28-oic-ursolic acid (9), presented the best anti-T...
March 23, 2018: Parasitology Research
https://www.readbyqxmd.com/read/29563165/risk-factors-for-mycoplasma-genitalium-endometritis-and-incident-infection-a-secondary-data-analysis-of-the-t-cell-response-against-chlamydia-trac-study
#15
Brandie D Taylor, Xiaojing Zheng, Catherine M O'Connell, Harold C Wiesenfeld, Sharon L Hillier, Toni Darville
OBJECTIVE: Assess risk factors for incident and endometrial Mycoplasma genitalium infection and determine if M. genitalium is associated with histological endometritis, an indicator of pelvic inflammatory disease. METHODS: This study was a secondary data analysis within the T cell Response Against Chlamydia (TRAC) Study, a prospective evaluation of 246 women with or at risk for Chlamydia trachomatis from urban outpatient clinics, who were followed quarterly for 12 months...
March 21, 2018: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/29560055/high-prevalence-of-sterile-pyuria-in-the-setting-of-sexually-transmitted-infection-in-women-presenting-to-an-emergency-department
#16
Stacia B Shipman, Chelsea R Risinger, Crystalle M Evans, Chelsey D Gilbertson, David E Hogan
Introduction: The clinical presentations for sexually transmitted infections (STI) and urinary tract infections (UTI) often overlap, and symptoms of dysuria and urinary frequency/urgency occur with both STIs and UTIs. Abnormal urinalysis (UA) findings and pyuria are common in both UTIs and STIs, and confirmatory urine cultures are not available to emergency clinicians to aid in decision-making regarding prescribing antibiotics for UTIs. The objective of this study was to determine the frequency of sterile pyuria in women with confirmed STIs, as well as whether the absolute number of leukocytes on microscopy or nitrite on urine dipstick correlated with positive urine cultures in patients with confirmed STIs...
March 2018: Western Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29559392/identifying-a-consensus-sample-type-to-test-for-chlamydia-trachomatis-neisseria-gonorrhoeae-mycoplasma-genitalium-trichomonas-vaginalis-and-human-papillomavirus
#17
Liselotte Coorevits, Ans Traen, Luk Bingé, Jo Van Dorpe, Marleen Praet, Jerina Boelens, Elizaveta Padalko
OBJECTIVES: Sexually transmitted infections (STIs) are a global cause of acute illness. Early detection plays a crucial role in interrupting transmission and preventing complications. However, the accessibility of STI testing is curbed by the lack of an overall preferred sample type. By means of a prospective study in female sex workers (FSW), we compared the sensitivity of samples from different anatomical sites in detecting Neisseria gonorrhoeae, Chlamydia trachomatis, Trichomonas vaginalis, Mycoplasma genitalium and human papillomavirus...
March 17, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29554238/prevalence-and-correlates-of-trichomonas-vaginalis-infection-among-men-and-women-in-the-united-states
#18
Eshan U Patel, Charlotte A Gaydos, Zoe R Packman, Thomas C Quinn, Aaron A R Tobian
Background: The epidemiology of Trichomonas vaginalis (TV) infection in the United States is poorly defined. Methods: Males and females aged 18-59 years who participated in the 2013-2014 National Health and Nutrition Examination Survey and provided a urine specimen were tested for TV infection (n = 4057). Participants were also examined for Chlamydia trachomatis (CT) infection, genital human papillomavirus (HPV) infection, and herpes simplex virus type 2 serostatus...
March 15, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29554227/why-does-trichomonas-vaginalis-continue-to-be-a-neglected-sexually-transmitted-infection
#19
Christina A Muzny
No abstract text is available yet for this article.
March 15, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29553074/-validation-of-the-kit-for-detecting-mycoplasma-genitalium-from-the-male-urethritis
#20
Ryoichi Hamasuna, Masahiro Matsumoto, Phuong Thi LE, Naohiro Fujimoto, Tetsuro Matsumoto
Mycoplasma genitalium is one of the pathogenic microorganisms in male urethritis as a sexually transmitted infection (STI). M.genitalium is detected in the urine specimens of 15-25% male patients with urethritis. The emergence of macrolide- or fluoroquinolone-resistant M.genitalium has become a serious problem in the treatment of male urethritis worldwide, but there is no commercial-based detecting kits accepted by the national insurance in Japan. In this study, we tested the validity of a molecular kit for detecting seven microorganisms related to STI (Anyplex™ II STI-7 Detection which detects Neisseria gonorrhoeae, Chlamydia trachomatis, M...
2018: Journal of UOEH
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