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https://www.readbyqxmd.com/read/28070215/multiple-hpv-infections-in-female-sex-workers-in-western-kenya-implications-for-prophylactic-vaccines-within-this-sub-population
#1
Sonia Menon, Davy van den Broeck, Rodolfo Rossi, Emilomo Ogbe, Hillary Mabeya
BACKGROUND: Whilst the imputed role of High Risk (HR) HPV infection in the development of cervical lesions and cancer has been established, the high number of HPV genotypes that Female Sex workers (FSW) harbour warrants that the synergistic effects of potential HR (pHR) and HR HPV genotypes be elucidated to assess the potential impact of prophylactic vaccines. This population in Kenya also harbours a number of other vaginal infections and STIs, including bacterial vaginosis (BV), trichomonas vaginalis (TV) and candida spp...
2017: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/28063567/vulvovaginite-d%C3%A3-pistage-et-prise-en-charge-de-la-trichomonase-de-la-candidose-vulvovaginale-et-de-la-vaginose-bact%C3%A3-rienne
#2
Julie van Schalkwyk, Mark H Yudin
OBJECTIF: Analyser les données probantes et formuler des recommandations quant au dépistage et à la prise en charge de la candidose vulvovaginale, de la trichomonase et de la vaginose bactérienne. ISSUES: Parmi les issues évaluées, on trouve l'efficacité de l'antibiothérapie, les taux de guérison en ce qui concerne les infections simples et compliquées, et les implications de ces pathologies pendant la grossesse. RéSULTATS: La littérature publiée a été récupérée par l'intermédiaire de recherches menées dans MEDLINE, EMBASE, CINAHL et The Cochrane Library en juin 2013 au moyen d'un vocabulaire contrôlé (p...
December 2016: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/28060011/topical-tenofovir-protects-against-vaginal-shiv-infection-in-macaques-co-infected-with-chlamydia-trachomatis-and-trichomonas-vaginalis
#3
Natalia Makarova, Tara Henning, Andrew Taylor, Chuong Dinh, Jonathan Lipscomb, Rachael Aubert, Debra Hanson, Christi Phillips, John Papp, James Mitchell, Janet Mcnicholl, Gerardo J Garcia-Lerma, Walid Heneine, Ellen Kersh, Charles Dobard
BACKGROUND: Chlamydia trachomatis (CT) and Trichomonas vaginalis (TV), two prevalent sexual transmitted infections, are known to increase HIV risk in women and could potentially diminish pre-exposure prophylaxis (PrEP) efficacy, particularly for topical interventions that rely on local protection. We investigated in macaques whether co-infection with CT/TV reduces protection by vaginal TFV gel. METHODS: Vaginal TFV gel dosing previously shown to provide 100% or 74% protection when applied either 30 minutes or 3 days before SHIV challenge was assessed in pigtailed macaques co-infected with CT/TV and challenged twice-weekly with SHIV162p3 for up to 10 weeks (2 menstrual cycles)...
January 4, 2017: AIDS
https://www.readbyqxmd.com/read/28054438/epigenetic-regulates-transcription-and-pathogenesis-in-the-parasite-trichomonas-vaginalis
#4
Tomas Pachano, Yesica R Nievas, Ayelen Lizarraga, Patricia J Johnson, Pablo H Strobl-Mazzulla, Natalia de Miguel
Trichomonas vaginalis is a common sexually transmitted parasite that colonizes the human urogenital tract. Infections range from asymptomatic to highly inflammatory, depending on the host and the parasite strain. Different T. vaginalis strains vary greatly in their adherence and cytolysis capacities. These phenotypic differences might be attributed to differentially expressed genes as a consequence of extra-genetic variation, such as epigenetic modifications. In this study we explored the role of histone acetylation in regulating gene transcription and pathogenesis in T...
January 5, 2017: Cellular Microbiology
https://www.readbyqxmd.com/read/28050410/prevalence-of-trichomonas-vaginalis-and-candida-albicans-among-brazilian-women-of-reproductive-age
#5
Mateus De Paula Glehn, Lana Cristina Evangelista Sá Ferreira, Hian Delfino Ferreira Da Silva, Eleuza Rodrigues Machado
INTRODUCTION: There are no studies assessing the simultaneous occurrence of Candida albicans (C. albicans) and Trichomonas vaginalis (T. vaginalis) in the primary health care in Brazil. Despite different conditions to establishment of each one, the co-detection of both has been reported by some authors in previous studies from other regions. AIM: To compare the prevalence of T. vaginalis and C. albicans in correlation with associated variables. MATERIALS AND METHODS: A cross-sectional study conducted in a family health clinic in the Federal District of Brazil, between November 2014 and March 2015...
November 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28042211/a-study-on-the-prevalence-of-genital-trichomoniasis-among-female-outpatients-attending-sexually-transmitted-infection-clinic-in-a-tertiary-care-hospital
#6
Swapna Muthusamy, Selvi Elangovan
INTRODUCTION: Women with high-risk sexual behavior accounts for more than half of the sexually transmitted infection (STI) clinic attendees. The prevalence of trichomoniasis is as low as 5% in the general population to as high as 60% in high-risk population. This infection can pave the way to the acquisition of human immunodeficiency virus and other STIs, vice versa and is even associated with cancer. OBJECTIVES: To identify, isolate and study the prevalence of Trichomonas vaginalis in genital specimens of female outpatients...
January 2017: Journal of Laboratory Physicians
https://www.readbyqxmd.com/read/28007229/sexually-transmitted-diseases-and-infertility
#7
REVIEW
Danielle G Tsevat, Harold C Wiesenfeld, Caitlin Parks, Jeffrey F Peipert
Female infertility, including tubal factor infertility, is a major public health concern worldwide. Most cases of tubal factor infertility are attributable to untreated sexually transmitted diseases that ascend along the reproductive tract and are capable of causing tubal inflammation, damage, and scarring. Evidence has consistently demonstrated the effects of Chlamydia trachomatis and Neisseria gonorrhoeae as pathogenic bacteria involved in reproductive tract morbidities including tubal factor infertility and pelvic inflammatory disease...
January 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27992790/association-between-high-risk-human-papillomavirus-infection-and-co-infection-with-candida-spp-and-trichomonas-vaginalis-in-women-with-cervical-premalignant-and-malignant-lesions
#8
Ishita Ghosh, Richard Muwonge, Srabani Mittal, Dipanwita Banerjee, Pratip Kundu, Ranajit Mandal, Jaydip Biswas, Partha Basu
BACKGROUND: Human papillomavirus (HPV) is the necessary cause of cervical cancer. Cervico-vaginal infection with pathogens like Chlamydia is a likely cofactor. The interactions between HPV, Trichomonas vaginalis (TV) and Candida spp. are less understood, though inflammation induced by these pathogens has been demonstrated to facilitate oncogenesis. OBJECTIVE: Our study aimed to evaluate the association between Candida spp. and TV co-infection with HPV in cervical oncogenesis...
December 12, 2016: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/27984554/trichomonas-vaginalis-treated-with-boric-acid-in-a-metronidazole-allergic-female
#9
Kandis Vechelle Backus, Christina A Muzny, Laura S Beauchamps
No abstract text is available yet for this article.
December 14, 2016: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/27981254/ginger-zingiber-officinale-induces-apoptosis-in-trichomonas-vaginalis-in-vitro
#10
Mohsen Arbabi, Mahdi Delavari, Zohre Fakhrieh Kashan, Mohsen Taghizadeh, Hossein Hooshyar
BACKGROUND: Trichomoniasis is the most common sexually transmitted protozoan diseases in the worldwide. Metronidazole is the choice drug for trichomoniasis treatment, however, metronidazole resistant Trichomonas vaginalis (T.vaginalis) has been reported. Natural products are the source of most new drugs, and Zingiber officinale (Ginger) is widely used ingredient in the traditional medicine. OBJECTIVE: The aim of the present study was to determine the effect of different concentrations of the ginger ethanol extract on the growth of T...
November 2016: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/27974960/prevalence-and-associated-factors-of-genital-and-sexually-transmitted-infections-in-married-women-of-iran
#11
Elahe Ahmadnia, Roghieh Kharaghani, Azam Maleki, Azar Avazeh, Saeideh Mazloomzadeh, Tahereh Sedaghatpisheh, Ahmad Jalilvand, Behnaz Molae
OBJECTIVES: This study aimed to determine the prevalence of genital and sexually transmitted infections and its related factors in married women in Iran. METHODS: We conducted a cross-sectional study of 4 274 married women living in urban and rural areas of the Zanjan province from 2012 to 2013. We used stratified cluster sampling to select the participants. Data collection included demographic characteristics, reproductive status, and cervical cytology results...
November 2016: Oman Medical Journal
https://www.readbyqxmd.com/read/27956086/the-caatinga-endemic-manilkara-rufula-possesses-remarkable-activity-against-trichomonas-vaginalis-and-tritrichomonas-foetus
#12
Patrícia de Brum Vieira, Nícolas Luiz Feijó Silva, Denise Brentan Silva, Norberto Peporine Lopes, Alexandre Gomes da Silva, Márcia Vanusa da Silva, Jaume Bastida, Alexandre José Macedo, Tiana Tasca
Tritrichomonas foetus infects the bovine urogenital tract, causing bovine trichomoniasis. Significant economic losses may occur due to infertility and abortion among cattle. Trichomonas vaginalis is the causative agent of trichomoniasis; the most common but overlooked non-viral sexually transmitted disease worldwide. Human and bovine trichomoniasis present treatment restrictions and efforts to identify new alternatives are essential. The present study evaluated the anti-trichomonads activities of seven fractions from northwest endemic plant Manilkara rufula...
December 9, 2016: Experimental Parasitology
https://www.readbyqxmd.com/read/27936227/epidemiology-of-trichomoniasis-in-south-korea-and-increasing-trend-in-incidence-health-insurance-review-and-assessment-2009-2014
#13
So-Young Joo, Youn-Kyoung Goo, Jae-Sook Ryu, Sang-Eun Lee, Won Kee Lee, Dong-Il Chung, Yeonchul Hong
Trichomoniasis, which is caused by Trichomonas vaginalis, is one of the most common non-viral sexually transmitted infections; however, limited population-based data are available that describe patterns and trends of the disease. We summarized insurance claims of trichomoniasis cases reported during 2009-2014 to South Korea Health Insurance Review and Assessment Service. The average annual incidence in South Korea was 276.8 persons per 100,000 population, and a substantial sex-associated variation was observed...
2016: PloS One
https://www.readbyqxmd.com/read/27934291/antiprotozoal-effects-of-the-tomato-tetrasaccharide-glycoalkaloid-tomatine-and-the-aglycone-tomatidine-on-mucosal-trichomonads
#14
Jenny Liu, Sierra Kanetake, Yun-Hsuan Wu, Christina Tam, Luisa W Cheng, Kirkwood M Land, Mendel Friedman
The present study investigated the inhibitory effects of the commercial tetrasaccharide tomato glycoalkaloid tomatine and the aglycone tomatidine on three mucosal pathogenic protozoa that are reported to infect humans, cattle, and cats, respectively: Trichomonas vaginalis strain G3, Tritrichomonas foetus strain D1, and Tritrichomonas foetus strain C1. A preliminary screen showed that tomatine at 100 μM concentration completely inhibited the growth of all three trichomonads. In contrast, the inhibition of all three pathogens by tomatidine was much lower, suggesting the involvement of the lycotetraose carbohydrate side chain in the mechanism of inhibition...
November 23, 2016: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/27928981/characterization-of-cyclin-dependent-kinases-and-cdc2-cdc28-kinase-subunits-in-trichomonas-vaginalis
#15
Erick Amador, Karla López-Pacheco, Nataly Morales, Roberto Coria, Imelda López-Villaseñor
Cyclin-dependent kinases (CDKs) have important roles in regulating key checkpoints between stages of the cell cycle. Their activity is tightly regulated through a variety of mechanisms, including through binding with cyclin proteins and the Cdc2/Cdc28 kinase subunit (CKS), and their phosphorylation at specific amino acids. Studies of the components involved in cell cycle control in parasitic protozoa are limited. Trichomonas vaginalis is the causative agent of trichomoniasis in humans and is therefore important in public health; however, some of the basic biological processes used by this organism have not been defined...
December 8, 2016: Parasitology
https://www.readbyqxmd.com/read/27904880/microbial-community-patterns-associated-with-automated-teller-machine-keypads-in-new-york-city
#16
Holly M Bik, Julia M Maritz, Albert Luong, Hakdong Shin, Maria Gloria Dominguez-Bello, Jane M Carlton
In densely populated urban environments, the distribution of microbes and the drivers of microbial community assemblages are not well understood. In sprawling metropolitan habitats, the "urban microbiome" may represent a mix of human-associated and environmental taxa. Here we carried out a baseline study of automated teller machine (ATM) keypads in New York City (NYC). Our goal was to describe the biodiversity and biogeography of both prokaryotic and eukaryotic microbes in an urban setting while assessing the potential source of microbial assemblages on ATM keypads...
November 2016: MSphere
https://www.readbyqxmd.com/read/27898571/single-dose-compared-with-multidose-metronidazole-for-the-treatment-of-trichomoniasis-in-women-a-meta-analysis
#17
Katharine Howe, Patricia J Kissinger
BACKGROUND: Trichomonas vaginalis is the most common curable sexually transmitted infection worldwide. Although the Centers for Disease Control and Prevention and the World Health Organization recommend a single 2-g dose of metronidazole for the first line of treatment for T. vaginalis among human immunodeficiency virus (HIV) negative women, high rates of repeat infections are found. The purpose of this meta-analysis was to compare treatment failure between single versus multidose metronidazole for the treatment of T...
January 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/27898565/quantitative-real-time-polymerase-chain-reaction-for-the-diagnosis-of-mycoplasma-genitalium-infection-in-south-african-men-with-and-without-symptoms-of-urethritis
#18
Marie Cecilia le Roux, Anwar Ahmed Hoosen
BACKGROUND: This study was done to diagnose Mycoplasma genitalium infection based on bacterial load in urine specimens from symptomatic and asymptomatic men. METHODS: Urine specimens from 94 men with visible urethral discharge, 206 with burning on micturition and 75 without symptoms presenting to a family practitioner were tested for M. genitalium as well as Neisseria gonorrhoeae, Chlamydia trachomatis, Trichomonas vaginalis by transcription-mediated amplification assays...
January 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/27894204/clinical-laboratory-assessments-for-mycoplasma-genitalium-in-a-high-prevalence-sexually-transmitted-infection-community-reveal-epidemiologic-dichotomies-with-trichomonas-vaginalis
#19
Erik Munson, Kimber L Munson, Ronald F Schell
Mycoplasma genitalium is an emerging agent of sexually-transmitted infection and is responsible for clinically-significant genital tract disease in both females and males. Similar to scenarios recently experienced with the urogenital flagellate Trichomonas vaginalis, an evolving molecular diagnostic reference standard based on transcription-mediated amplification allows for accurate detection of the organism, plus additional insight into disease epidemiology. Areas covered. The basis for this article includes primary peer-reviewed literature plus compilations of data derived from routine clinical laboratory screening of females and males for agents of sexually-transmitted infection...
December 10, 2016: Expert Review of Anti-infective Therapy
https://www.readbyqxmd.com/read/27890510/in-situ-forming-pluronic%C3%A2-f127-chitosan-hydrogel-limits-metronidazole-transmucosal-absorption
#20
Sophia Malli, Christian Bories, Bénédicte Pradines, Philippe M Loiseau, Gilles Ponchel, Kawthar Bouchemal
The objective of this work is to design topically-applied thermosensitive and mucoadhesive hydrogel containing metronidazole (MTZ) for the treatment of Trichomonas vaginalis infections. Hydrogel composed of pluronic® F127 (20wt%), chitosan (1wt%) and metronidazole MTZ (0.7wt%) mixture showed its ability to decrease by a factor 4 MTZ flux and apparent permeability absorption through vaginal mucosa. The impact of hydrogel on transmucosal penetration of MTZ was evaluated ex vivo on excised porcine vaginal mucosa mounted on Franz diffusion cell...
November 24, 2016: European Journal of Pharmaceutics and Biopharmaceutics
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