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Christian Quinet, Guy Czaplicki, Elise Dion, Fabiana Dal Pozzo, Anke Kurz, Claude Saegerman
BACKGROUND: Infection due to bovine viral diarrhoea virus (BVDV) is endemic in most cattle-producing countries throughout the world. The key elements of a BVDV control programme are biosecurity, elimination of persistently infected animals and surveillance. Bovine viral diarrhoea (BVD) is a notifiable disease in Belgium and an official eradication programme started from January 2015, based on testing ear notches sampled during the official identification and registration of calves at birth...
2016: PloS One
Frederike Reichmann, Annette Pfitzner, Guenter Rademacher, Elke Schwedinger, Klaus Cussler, Carola M Sauter-Louis
BACKGROUND: Several research groups from different European countries have worked on the aetiopathogenesis of bovine neonatal pancytopenia (BNP) and an association between the use of the vaccine PregSure BVD (Pfizer, Germany) and the development of this haemorrhagic disease was confirmed. Because BNP is not a notifiable disease, it is difficult to obtain information on its incidence. Based on pharmacovigilance (PhV) data, which are the only officially available data at the national level, the incidence of BNP is considered low...
October 7, 2016: BMC Veterinary Research
A Stoll, A Pfitzner-Friedrich, F Reichmann, J Rauschendorfer, A Roessler, G Rademacher, G Knubben-Schweizer, C Sauter-Louis
Haemorrhagic diathesis (HD) in cattle is a relatively rare syndrome that can have many different causes. With the occurrence of bovine neonatal pancytopenia (BNP) in 2007, the number of cases of HD in cattle has increased. This led to an enhanced interest in diseases presenting with bleeding disorders. The possible causes of HD in cattle, the clinical findings, and the course of various diseases are described and evaluated. Furthermore, we determined whether cases of BNP occurred before the introduction of the vaccine Pregsure BVD since its widespread use was associated with the syndrome...
October 2016: Veterinary Journal
Quan-Jiang Song, Xiao-Gang Weng, Dong-Jie Cai, Wang Zhang, Jiu-Feng Wang
Bovine viral diarrhea virus (BVDV), the causative agent of bovine viral diarrhea/mucosal disease (BVD/MD), is an important pathogen of cattle and other wild animals throughout the world. BVDV infection typically leads to an impaired immune response in cattle. In the present study, we investigated the effect of Forsythoside A (FTA) on BVDV infection of bovine peripheral blood mononuclear cells (PBMCs). We found that Forsythoside A could not only promote proliferation of PBMCs and T cells activation but also inhibit the replication of BVDV as well as apoptosis induced by BVDV...
2016: PloS One
Mengjie Liu, Rachel R Richardson, Simon J Mountford, Lei Zhang, Matheus H Tempone, Herbert Herzog, Nicholas D Holliday, Philip E Thompson
Traceable truncated Neuropeptide Y (NPY) analogues with Y1 receptor (Y1R) affinity and selectivity are highly desirable tools in studying receptor location, regulation, and biological functions. A range of fluorescently labeled analogues of a reported Y1R/Y4R preferring ligand BVD-15 have been prepared and evaluated using high content imaging techniques. One peptide, [Lys(2)(sCy5), Arg(4)]BVD-15, was characterized as an Y1R antagonist with a pKD of 7.2 measured by saturation analysis using fluorescent imaging...
September 21, 2016: Bioconjugate Chemistry
Einar K Rofstad, Ruixia Huang, Kanthi Galappathi, Lise Mari K Andersen, Catherine S Wegner, Anette Hauge, Jon-Vidar Gaustad, Trude G Simonsen
Studies of cell line-derived human tumor xenografts have suggested that the lymphatics seen in immunohistochemical preparations from non-peripheral regions of tumors are nonfunctional. In this investigation, lymphangiogenesis, hemangiogenesis, and lymph node metastasis were studied in patient-derived xenograft (PDX) models of carcinoma of the uterine cervix. Lymph vessel density (LVD) and blood vessel density (BVD) were measured in immunohistochemical preparations. The expression of angiogenesis-related genes was investigated by quantitative PCR...
July 29, 2016: Oncotarget
Jörn Gethmann, Timo Homeier, Mark Holsteg, Horst Schirrmeier, Michael Saßerath, Bernd Hoffmann, Martin Beer, Franz J Conraths
In November 2012, a dairy farmer in the district Kleve first observed a reduction in milk yield, respiratory symptoms, nasal discharge, fever, sporadic diarrhoea and sudden deaths in dairy cows and calves. In the following months, further farms were found infected with cattle showing similar clinical signs. An epidemiological investigation was carried out to identify the source of infection, the date of introduction, potential transmission pathways and to analyse the extent of the epidemic. Furthermore, laboratory analyses were conducted to characterise the causative agent...
September 2015: Heliyon
Basanta Bhaduri, Ryan M Nolan, Ryan L Shelton, Lara A Pilutti, Robert W Motl, Heather E Moss, John H Pula, Stephen A Boppart
Although retinal vasculitis is common in multiple sclerosis (MS), it is not known if MS is associated with quantitative abnormalities in retinal blood vessels (BVs). Optical coherence tomography (OCT) is suitable for examining the integrity of the anterior visual pathways in MS. In this paper we have compared the size and number of retinal blood vessels in patients with MS, with and without a history of optic neuritis (ON), and control subjects from the cross-sectional retinal images from OCT. Blood vessel diameter (BVD), blood vessel number (BVN), and retinal nerve fiber layer thickness (RNFLT) were extracted from OCT images collected from around the optic nerves of 129 eyes (24 control, 24 MS + ON, 81 MS-ON) of 71 subjects...
June 1, 2016: Biomedical Optics Express
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No abstract text is available yet for this article.
July 2, 2016: Veterinary Record
Ágnes Szabára, Zsolt Lang, József Földi, Ákos Hornyák, Tamás Abonyi, László Ózsvári
A study was performed to survey the virological prevalence of bovine viral diarrhoea (BVD) virus (BVDV) in cattle herds in Hungary between 2008 and 2012. A total of 40,413 samples for BVDV detection and 24,547 samples for antibody testing were collected from 3,247 herds (570,524 animals), thus representing approximately 75% of the cattle population in Hungary. Retrospective Bayesian analysis demonstrated that (1) the herd-level true virus prevalence was 12.4%, (2) the mean individual (within-herd) true virus prevalence was 7...
June 2016: Acta Veterinaria Hungarica
Alessandro Foddai, Anders Stockmarr, Anette Boklund
BACKGROUND: The temporal sensitivity of the surveillance system (TemSSe) for Bovine Viral Diarrhea (BVD) in Danish dairy herds was evaluated. Currently, the Danish antibody blocking ELISA is used to test quarterly bulk tank milk (BTM). To optimize the surveillance system as an early warning system, we considered the possibility of using the SVANOVIR ELISA, as this test has been shown to detect BVD-positive herds earlier than the blocking ELISA in BTM tests. Information from data (2010) and outputs from two published stochastic models were fed into a stochastic scenario tree to estimate the TemSSe...
2016: BMC Veterinary Research
Mengjie Liu, Simon J Mountford, Rachel R Richardson, Marleen Groenen, Nicholas D Holliday, Philip E Thompson
The dimeric peptide 1 (BVD-74D, as a diastereomeric mixture) is a potent and selective neuropeptide Y Y4 receptor agonist. It represents a valuable candidate in developing traceable ligands for pharmacological studies of Y4 receptors and as a lead compound for antiobesity drugs. Its optically pure stereoisomers along with analogues and fluorescently labeled variants were prepared by exploiting alkene metathesis reactions. The (2R,7R)-diaminosuberoyl containing peptide, (R,R)-1, had markedly higher affinity and agonist efficacy than its (S,S)-counterpart...
July 14, 2016: Journal of Medicinal Chemistry
Trine Schow, Thomas William Teasdale, Kirsten Jensen Quas, Morten Arendt Rasmussen
BACKGROUND: Fatigue after stroke is hard to define and measure and how it is associated with other complications after stroke still needs to be explored. These issues are relevant in stroke rehabilitation and in the patient's daily life. OBJECTIVE: To investigate fatigue after stroke and its relation to balance, gait, and Binocular Visual Dysfunction (BVD). METHODS: Adults with stroke (n = 29, age 18-67 years) were tested with the Modified Fatigue Impact Scale (MFIS), objective and subjective BVD measures, Balance Evaluation Systems Test, Ten Meter Walk Test, and a Health-Related Quality of Life questionnaire, before and after a four-month intervention program and at three- and six-month follow-ups...
June 7, 2016: Topics in Stroke Rehabilitation
Kilian K Kuhn, Thomas Ertl, Stefanie Dukorn, Max Keller, Günther Bernhardt, Oliver Reiser, Armin Buschauer
The diastereomeric mixture of d/l-2,7-diaminooctanedioyl-bis(YRLRY-NH2) (BVD-74D, 2) was described in the literature as a high affinity Y4 receptor agonist. Here we report on the synthesis and pharmacological characterization of the pure diastereomers (2R,7R)- and (2S,7S)-2 and a series of homo- and heterodimeric analogues in which octanedioic acid was used as an achiral linker. To investigate the role of the Arg residues, one or two arginines were replaced by Ala. Moreover, N(ω)-(6-aminohexylaminocarbonyl)Arg was introduced as an arginine replacement (17)...
July 14, 2016: Journal of Medicinal Chemistry
Chunli Zheng, Tianli Pei, Chao Huang, Xuetong Chen, Yaofei Bai, Jun Xue, Ziyin Wu, Jiexin Mu, Yan Li, Yonghua Wang
Due to the large direct and indirect productivity losses in the livestock industry caused by Bovine Viral Diarrhea (BVD) and the lack of effective pharmacological therapies, developing an efficient treatment is extremely urgent. Traditional Chinese medicines (TCMs) that simultaneously address multiple targets have been proven to be effective therapies for BVD. However, the potential molecular action mechanisms of TCMs have not yet been systematically explored. In this work, take the example of a herbal remedy Huangqin Zhizi (HQZZ) for BVD treatment in China, a systems pharmacology approach combining with the pharmacokinetics and pharmacodynamics evaluation was developed to screen out the active ingredients, predict the targets and analyze the networks and pathways...
May 18, 2016: European Journal of Pharmaceutical Sciences
Johann Burgstaller, Walter Obritzhauser, Sabrina Kuchling, Ian Kopacka, Beate Pinior, Josef Köfer
Bovine viral diarrhoea (BVD) leads to substantial economic losses in beef and dairy herds worldwide. Two case-control studies were carried out using production data from 1996 to 2012 to analyse the impact of BVD virus (BVDV) on fertility in dairy herds in the province of Styria during an eradication programme. In study 1, herds in which at least one persistently BVDV-infected (PI) animal was detected (case herds) were compared to a group of control herds proven free from BVDV infection (contro herds). In study 2, within BVD infected herds the period during which P animals were present (exposed period) was compared to the period after successful BVD eradication (unexposed period)...
March 2016: Berliner und Münchener Tierärztliche Wochenschrift
Roman Paduch
BACKGROUND: Metastasis is the main cause of mortality in cancer patients. Two major routes of cancer cell spread are currently being recognized: dissemination via blood vessels (hematogenous spread) and dissemination via the lymphatic system (lymphogenous spread). Here, our current knowledge on the role of both blood and lymphatic vessels in cancer cell metastasis is summarized. In addition, I will discuss why cancer cells select one or both of the two routes to disseminate and I will provide a short description of the passive and active models of intravasation...
April 28, 2016: Cellular Oncology (Dordrecht)
Ken-Ichiro Kameyama, Misako Konishi, Toshiyuki Tsutsui, Takehisa Yamamoto
To establish effective and efficient control measures for bovine viral diarrhea (BVD) in Japan, a pilot survey on persistently infected (PI) animals in dairy farms was conducted. A total of 5,949 cattle from 79 farms in 11 prefectures were tested; seven cattle in six farms were identified as PI animals. The proportion of farms with PI animals in Japan was calculated as 7.6% (95% confidence interval: 3.1-16.4%), and proportion of cattle tested as PI animals was 0.12% (95% confidence interval: 0.05-0.25%). The presence of only one or two animals in PI positive farms suggested the application of screening tests covering almost all cattle in each farm using pooled serum or bulk milk could be effective for implementing a large-scale survey for detecting PI animals...
September 1, 2016: Journal of Veterinary Medical Science
Trine Schow, Paul Harris, Thomas William Teasdale, Morten Arendt Rasmussen
BACKGROUND: Balance problems and binocular visual dysfunction (BVD) are common problems after stroke, however evidence of an effective rehabilitation method are limited. OBJECTIVE: To evaluate the effect of a four-month rehabilitation program for individuals with balance problems and BVD after a stroke. METHODS: About 40 sessions of 1.5 hours duration over four months with visual therapy and balance rehabilitation, was provided to all 29 participants, aged 18-67 years, in groups of 7-8 individuals...
April 6, 2016: NeuroRehabilitation
Laura Lucchese, Abdelali Benkirane, Imane Hakimi, Ahmed El Idrissi, Alda Natale
Sera from 221 cattle were collected in 25 farms in Morocco to investigate the evidence and circulation of some of the main bovine abortive agents in the dairy cattle farming, where abortions are often reported. All sera were examined for brucellosis, 176 for neosporosis, 88 for leptospirosis, and 42 for Bovine viral diarrhoea (BVD/MD), Bovine Herpesvirus 1 (BHV-1) (Infectious bovine rhinotracheitis, IBR/IPV), and Bovine Herpesvirus 4 (BHV-4) infections (at least 1 sample per herd). Abortions were reported in 23 (10...
January 2016: Veterinaria Italiana
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