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https://www.readbyqxmd.com/read/29096959/modelling-the-fine-scale-spatiotemporal-pattern-of-urban-heat-island-effect-using-land-use-regression-approach-in-a-megacity
#1
Yuan Shi, Lutz Katzschner, Edward Ng
Urban heat island (UHI) effect significantly raises the health burden and building energy consumption in the high-density urban environment of Hong Kong. A better understanding of the spatiotemporal pattern of UHI is essential to health risk assessments and energy consumption management but challenging in a high-density environment due to the sparsely distributed meteorological stations and the highly diverse urban features. In this study, we modelled the spatiotemporal pattern of UHI effect using the land use regression (LUR) approach in geographic information system with meteorological records of the recent 4years (2013-2016), sounding data and geographic predictors in Hong Kong...
October 30, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29081918/seroprevalence-and-risk-factors-for-peste-des-petits-ruminants-and-selected-differential-diagnosis-in-sheep-and-goats-in-tanzania
#2
Emeli Torsson, Mikael Berg, Gerald Misinzo, Ida Herbe, Tebogo Kgotlele, Malin Päärni, Nils Roos, Anne-Lie Blomström, Karl Ståhl, Jonas Johansson Wensman
Introduction: Livestock husbandry is critical for food security and poverty reduction in a low-income country like Tanzania. Infectious disease is one of the major constraints reducing the productivity in this sector. Peste des petits ruminants (PPR) is one of the most important diseases affecting small ruminants, but other infectious diseases may also be present. Objective: The objective of this study was to determine the seroprevalence and risk factors for exposure to PPR, contagious caprine pleuropneumonia (CCPP), foot-and-mouth disease (FMD), bluetongue (BT), and bovine viral diarrhoea (BVD) in sheep and goats in Tanzania...
2017: Infection Ecology & Epidemiology
https://www.readbyqxmd.com/read/29057796/six-years-2011-2016-of-mandatory-nationwide-bovine-viral-diarrhea-control-in-germany-a-success-story
#3
Kerstin Wernike, Jörn Gethmann, Horst Schirrmeier, Ronald Schröder, Franz J Conraths, Martin Beer
Bovine viral diarrhea (BVD) is one of the most important infectious diseases in cattle, causing major economic losses worldwide. Therefore, control programs have been implemented in several countries. In Germany, an obligatory nationwide eradication program has been in force since 2011. Its centerpiece is the detection of animals persistently infected (PI) with BVD virus, primarily based on the testing of ear tissue samples of all newborn calves for viral genome or antigen, and their removal from the cattle population...
October 18, 2017: Pathogens
https://www.readbyqxmd.com/read/28966859/computer-aided-classification-of-sickle-cell-retinopathy-using-quantitative-features-in-optical-coherence-tomography-angiography
#4
Minhaj Alam, Damber Thapa, Jennifer I Lim, Dingcai Cao, Xincheng Yao
As a new optical coherence tomography (OCT) imaging modality, there is no standardized quantitative interpretation of OCT angiography (OCTA) characteristics of sickle cell retinopathy (SCR). This study is to demonstrate computer-aided SCR classification using quantitative OCTA features, i.e., blood vessel tortuosity (BVT), blood vessel diameter (BVD), vessel perimeter index (VPI), foveal avascular zone (FAZ) area, FAZ contour irregularity, parafoveal avascular density (PAD). It was observed that combined features show improved classification performance, compared to single feature...
September 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/28939558/targeting-the-mapk-signaling-pathway-in-cancer-promising-preclinical-activity-with-the-novel-selective-erk1-2-inhibitor-bvd-523-ulixertinib
#5
Ursula A Germann, Brinley F Furey, William Markland, Russell R Hoover, Alex M Aronov, Jeffrey J Roix, Micheal Hale, Diane M Boucher, David A Sorrell, Gabriel Martinez-Botella, Matthew Fitzgibbon, Paul Shapiro, Michael J Wick, Ramin Samadani, Kathryn Meshaw, Anna Groover, Gary DeCrescenzo, Mark Namchuk, Caroline M Emery, Saurabh Saha, Dean J Welsch
Aberrant activation of signaling through the RAS-RAF-MEK-ERK (MAPK) pathway is implicated in numerous cancers, making it an attractive therapeutic target. Although BRAF- and MEK-targeted combination therapy has demonstrated significant benefit beyond single-agent options, the majority of patients develop resistance and disease progression after approximately 12 months. Reactivation of ERK signaling is a common driver of resistance in this setting. Here we report the discovery of BVD-523 (ulixertinib), a novel, reversible, ATP-competitive ERK1/2 inhibitor with high potency and ERK1/2 selectivity...
September 22, 2017: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/28926013/insights-for-the-assessment-of-the-economic-impact-of-endemic-diseases-specific-adaptation-of-economic-frameworks-using-the-case-of-bovine-viral-diarrhoea
#6
A W Stott, G J Gunn
Generic frameworks for the economic analysis of farm animal disease are now well established. The paper, therefore, uses bovine viral diarrhoea (BVD) as an example to explore how these frameworks need to be adapted to fit the characteristics of a particular disease and the specific objectives of the analysis. In the case of BVD, given the relative strength of tests available to correctly identify virus-positive animals, thus enabling them to be culled, the emphasis has been on cost-benefit analysis of regional and national certification/eradication schemes...
April 2017: Revue Scientifique et Technique
https://www.readbyqxmd.com/read/28903865/economic-evaluation-of-the-eradication-program-for-bovine-viral-diarrhea-in-the-swiss-dairy-sector
#7
B Thomann, A Tschopp, I Magouras, M Meylan, G Schüpbach-Regula, B Häsler
Since 2008, the Swiss veterinary service has been running a mandatory eradication program for Bovine Viral Diarrhea (BVD) that is focused on detecting and eliminating persistently infected (PI) animals. Detection was initially based on antigen testing from ear tag samples of the entire cattle population, followed by antigen testing of all newborn calves until 2012. Since then, bulk milk serology (dairy herds) and blood sample serology (beef herds) have been used for the surveillance of disease-free herds. From 2008 to 2012, the proportion of newborn PI calves decreased from 1...
September 15, 2017: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/28888645/eradication-of-bovine-viral-diarrhea-virus-in-germany-diversity-of-subtypes-and-detection-of-live-vaccine-viruses
#8
Kerstin Wernike, Horst Schirrmeier, Heinz-Günter Strebelow, Martin Beer
Bovine viral diarrhea (BVD) causes high economic losses in the cattle population worldwide. In Germany, an obligatory control program with detection and removal of persistently infected animals is in force since 2011. For molecular tracing of virus transmission, a comprehensive sequence data base of the currently circulating BVD viruses was established. Partial sequences of 1007 samples collected between 2008 and 2016 were generated. As dominant viruses, subtypes 1b (47.0%) and 1d (26.5%) could be identified with no marked geographic or sampling year effect, a much higher amount of BVDV-2c was detected in 2013 compared to other years, predominantly in Western Germany...
September 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/28883101/wales-launches-voluntary-bvd-screening-programme-in-bid-to-eradicate-disease
#9
(no author information available yet)
No abstract text is available yet for this article.
September 9, 2017: Veterinary Record
https://www.readbyqxmd.com/read/28864505/scotland-pushes-for-tougher-action-on-cattle-farmers-to-eradicate-bvd
#10
(no author information available yet)
No abstract text is available yet for this article.
September 2, 2017: Veterinary Record
https://www.readbyqxmd.com/read/28851755/engaging-veterinarians-and-farmers-in-eradicating-bovine-viral-diarrhoea-a-systematic-review-of-economic-impact
#11
Matt J Yarnall, Michael V Thrusfield
Bovine viral diarrhoea (BVD) is a significant drain on efficient and successful cattle production in both dairy and beef systems around the world. Several countries have achieved eradication of this disease, but always through the motivation of stakeholders who accept the benefits of eradication. These include increased cattle welfare and fitness of cattle to withstand other diseases, and decreased costs of production, the latter resulting from both decreased costs spent on managing the disease and decreased losses...
August 29, 2017: Veterinary Record
https://www.readbyqxmd.com/read/28719137/neocortical-developmental-analysis-of-vasculature-and-their-growth-factors-offer-new-insight-into-fragile-x-syndrome-abnormalities
#12
Amogh P Belagodu, Stephen Fleming, Roberto Galvez
Fragile X Syndrome (FXS) is the most common single gene cause for Autism Spectrum Disorder and the most prevalent form of inherited mental retardation. Our prior studies have demonstrated that adult FXS mice have abnormal blood vessel density (BVD) and elevated Vascular Endothelial Growth Factor A expression (VEGF-A). VEGF-A is one of the most prominent regulators of BVD, and its abnormal expression is the most likely cause for FXS BVD abnormalities. We have demonstrated that attenuating elevated VEGF-A expression can ameliorate many non-vascular FXS abnormalities (Belagodu, Zendeli Slater and Galvez: Dev Neurobiol 77 (2017) 14-25), suggesting that abnormal VEGF-A expression is an underlying cause for some FXS abnormalities...
July 18, 2017: Developmental Neurobiology
https://www.readbyqxmd.com/read/28716201/a-matched-case-control-study-comparing-udder-health-production-and-fertility-parameters-in-dairy-farms-before-and-after-the-eradication-of-bovine-virus-diarrhoea-in-switzerland
#13
A Tschopp, R Deiss, M Rotzer, S Wanda, B Thomann, G Schüpbach-Regula, M Meylan
An obligatory eradication programme for Bovine Virus Diarrhoea (BVD) was implemented in Switzerland in 2008. Between 2008 and 2012, all bovines were tested for antigen or antibodies against BVDV. By the year 2012, eradication was completed in the majority of farms. A decrease of the prevalence of persistently infected (PI) newborn calves was observed from 1.4% in 2008 to <0.02% in 2012. The objective of the present study was to assess the effects of BVD eradication on different parameters of animal health, production and fertility in Swiss dairy herds which had completed the eradication programme...
September 1, 2017: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/28713492/salvianolic-acid-exerts-cardioprotection-through-promoting-angiogenesis-in-animal-models-of-acute-myocardial-infarction-preclinical-evidence
#14
REVIEW
Long-Jie Yu, Ke-Jian Zhang, Jia-Zhen Zhu, Qun Zheng, Xiao-Yi Bao, Saroj Thapa, Yan Wang, Mao-Ping Chu
Radix Salviae miltiorrhizae, danshen root (danshen), is one of the widely used Chinese herbal medicines in clinics, containing rich phenolic compounds. Salvianolic acid is the main active compound responsible for the pharmacologic effects of danshen. Here, we aimed to evaluate the effects of salvianolic acid on cardioprotection through promoting angiogenesis in experimental myocardial infarction. Studies of salvianolic acid in animal models of myocardial infarction were obtained from 6 databases until April 2016...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28679275/an-investigation-of-the-systematic-use-of-spectral-information-in-the-determination-of-apparent-talker-height
#15
Santiago Barreda
The perception of apparent-talker height is mostly determined by the fundamental frequency (f0) and spectral characteristics of a voice. Although it is traditionally thought that spectral cues affect apparent-talker height by influencing apparent vocal-tract length, a recent experiment [Barreda (2016). J. Phon. 55, 1-18] suggests that apparent-talker height can vary significantly within-talker on the basis of phonemically-determined spectral variability. In this experiment, listeners were asked to estimate the height of 10 female talkers based on manipulated natural productions of bVd words containing one of /i æ ɑ u ɝ/...
June 2017: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/28678850/herd-level-animal-management-factors-associated-with-the-occurrence-of-bovine-neonatal-pancytopenia-in-calves-in-a-multi-country-study
#16
Carola Sauter-Louis, Bryony A Jones, Jörg Henning, Alexander Stoll, Mirjam Nielen, Gerdien Van Schaik, Anja Smolenaars, Matthijs Schouten, Ingrid den Uijl, Christine Fourichon, Raphael Guatteo, Aurélien Madouasse, Simon Nusinovici, Piet Deprez, Sarne De Vliegher, Jozef Laureyns, Richard Booth, Jacqueline M Cardwell, Dirk U Pfeiffer
Since 2007, mortality associated with a previously unreported haemorrhagic disease has been observed in young calves in several European countries. The syndrome, which has been named 'bovine neonatal pancytopenia' (BNP), is characterised by thrombocytopenia, leukocytopenia and a panmyelophthisis. A herd-level case-control study was conducted in four BNP affected countries (Belgium, France, Germany and the Netherlands) to identify herd management risk factors for BNP occurrence. Data were collected using structured face-to-face and telephone interviews of farm managers and their local veterinarians...
2017: PloS One
https://www.readbyqxmd.com/read/28645788/effects-of-acute-altered-gravity-during-parabolic-flight-and-or-vestibular-loss-on-cell-proliferation-in-the-rat-dentate-gyrus
#17
Yiwen Zheng, Catherine M Gliddon, Phillip Aitken, Lucy Stiles, Marie-Laure Machado, Bruno Philoxene, Pierre Denise, Paul F Smith, Stephane Besnard
Both parabolic flight, i.e. a condition of altered gravity, and loss of vestibular function, have been suggested to affect spatial learning and memory, which is known to be influenced by neurogenesis in the hippocampus. In this study we investigated whether short alternated micro- and hyper-gravity stimulations during parabolic flight and/or loss of vestibular function, would alter cell proliferation in the hippocampal dentate gyrus of rats, by measuring the number of bromodeoxyuridine (BrdU)-incorporated cells...
June 20, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28606363/patterns-of-calving-and-young-stock-movement-in-ireland-and-their-implications-for-bvd-serosurveillance
#18
Jamie A Tratalos, David A Graham, Simon J More
The Republic of Ireland has a national eradication programme for bovine viral diarrhoea virus (BVDv) based on tissue-tag testing of calves to identify persistently infected animals (PIs). It has been proposed that serological testing of a sample of home-bred young stock would be a more cost effective surveillance mechanism than continued tissue-tag testing in herds which have previously been found to be BVD-free. These animals would have to be at least 6 months of age to avoid interference from maternal antibodies in test results...
July 1, 2017: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/28593886/correlation-between-microvessel-density-and-morphological-features-in-skin-squamous-cell-carcinoma
#19
Lena Kakasheva-Mazhenkovska, Neli Basheska, Simonida Crvenkova, Petrushevska Gordana, Liljana Milenkova, Vesna Janevska, Vladimir Serafimoski
INTRODUCTION: Abnormal angiogenesis is described in tumor growth and it facilitates its metastatic spread. Tumors with high angiogenic activity belong to the category of aggressive tumors with poor prognosis for patients. The aim of this study was to determine the blood vessels density (BVD), i.e. neovascularization at the tumor invasive front in skin squamous cell carcinoma (SCC) in order to determine its possible role in the tumor progression, and to correlate it to the blood vessels density of healthy skin and with the prognostic parameters of the TNM classification: T status, depth of tumor invasion (DI) and tumor histological grade (G), which were also correlated between each other...
March 1, 2017: Prilozi (Makedonska Akademija Na Naukite i Umetnostite. Oddelenie za Medicinski Nauki)
https://www.readbyqxmd.com/read/28582444/selection-and-characterization-of-specific-nanobody-against-bovine-virus-diarrhea-virus-bvdv-e2-protein
#20
Tiansen Li, Meiling Huang, Hongran Xiao, Guoqi Zhang, Jinhua Ding, Peng Wu, Hui Zhang, Jinliang Sheng, Chuangfu Chen
Bovine viral diarrhea-mucosal disease (BVD-MD) is caused by bovine viral diarrhea virus (BVDV), and results in abortion, stillbirth, and fetal malformation in cows. Here, we constructed the phage display vector pCANTAB 5E-VHH and then transformed it into Escherichia coli TG1-competent cells, to construct an initial anti-BVDV nanobody gene library. We obtained a BVDV-E2 antigen epitope bait protein by prokaryotic expression using the nucleotide sequence of the E2 gene of the BVDV-NADL strain published in GenBank...
2017: PloS One
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