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https://www.readbyqxmd.com/read/28207981/a-multiparametric-magnetic-resonance-imaging-based-risk-model-to-determine-the-risk-of-significant-prostate-cancer-prior-to-biopsy
#1
Pim J van Leeuwen, Andrew Hayen, James E Thompson, Daniel Moses, Ron Shnier, Maret Böhm, Magdaline Abuodha, Anne-Maree Haynes, Francis Ting, Jelle Barentsz, Monique Roobol, Justin Vass, Krishan Rasiah, Warick Delprado, Phillip D Stricker
OBJECTIVES: To develop and externally validate a predictive model for detection of significant prostate cancer (PC). SUBJECTS AND METHODS: Development of the model was based on prospective cohort including 393 men who underwent mpMRI prior to biopsy. External validity of the model was then examined retrospectively in 198 men from a separate institution whom underwent a mpMRI followed by biopsy for abnormal PSA/DRE. A model was developed with age, PSA, DRE, prostate volume, previous biopsy and PIRADS score as predictors for significant PC (Gleason 7 with >5% grade 4, ≥ 20% cores positive or ≥ 7mm of PC in any core)...
February 16, 2017: BJU International
https://www.readbyqxmd.com/read/28181054/an-evaluation-of-morphological-and-functional-multi-parametric-mri-sequences-in-classifying-non-muscle-and-muscle-invasive-bladder-cancer
#2
Valeria Panebianco, Ettore De Berardinis, Giovanni Barchetti, Giuseppe Simone, Constantino Leonardo, Marcello Domenico Grompone, Maurizio Del Monte, Davide Carano, Michele Gallucci, James Catto, Carlo Catalano
OBJECTIVES: Our goal is to determine the ability of multi-parametric magnetic resonance imaging (mpMRI) to differentiate muscle invasive bladder cancer (MIBC) from non-muscle invasive bladder cancer (NMIBC). METHODS: Patients underwent mpMRI before tumour resection. Four MRI sets, i.e. T2-weighted (T2W) + perfusion-weighted imaging (PWI), T2W plus diffusion-weighted imaging (DWI), T2W + DWI + PWI, and T2W + DWI + PWI + dif-fusion tensor imaging (DTI) were interpreted qualitatively by two radiologists, blinded to histology results...
February 8, 2017: European Radiology
https://www.readbyqxmd.com/read/28179286/italian-prostate-biopsies-group-2016-updated-guidelines-insights
#3
REVIEW
Andrea Fandella, Vincenzo Scattoni, Andrea Galosi, Pietro Pepe, Michelangelo Fiorentino, Caterina Gaudiano, Marco Giampaoli, Roberta Gunelli, Pasquale Martino, Vittorino Montanaro, Rodolfo Montironi, Tiziana Pierangeli, Armando Stabile, Alessandro Bertaccini
AIM: To present a summary of the updated guidelines of the Italian Prostate Biopsies Group following the best recent evidence of the literature. MATERIALS AND METHODS: A systematic review of the new data emerging from 2012-2015 was performed by a panel of 14 selected Italian experts in urology, pathology and radiology. The experts collected articles published in the English-language literature by performing a search using Medline, EMBASE and the Cochrane Library database...
2017: Anticancer Research
https://www.readbyqxmd.com/read/28164396/improved-multiparametric-mri-discrimination-between-low-risk-prostate-cancer-and-benign-tissues-in-a-small-cohort-of-5%C3%AE-reductase-inhibitor-treated-individuals-as-compared-with-an-untreated-cohort
#4
Olga Starobinets, John Kurhanewicz, Susan M Noworolski
The purpose of this study was to determine whether 5α-reductase inhibitors (5-ARIs) affect the discrimination between low-grade prostate cancer and benign tissues on multiparametric MRI (mpMRI). Twenty men with biopsy-proven Gleason 3 + 3 prostate cancer and 3 T mpMRI were studied. Ten patients (Tx) had been receiving 5-ARIs for at least a year at scan time. Ten untreated patients (Un) were matched to the treated cohort. For each subject two regions of interest representing cancerous and benign tissues were drawn within the peripheral zone of each prostate, MR measures evaluated, and cancer contrast versus benign (contrast = (MRTumor  - MRHealthy )/MRHealthy ) calculated...
February 6, 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/28163805/evidence-based-guideline-recommendations-on-multiparametric-magnetic-resonance-imaging-in-the-diagnosis-of-prostate-cancer-a-cancer-care-ontario-clinical-practice-guideline
#5
Masoom A Haider, Xiaomei Yao, Andrew Loblaw, Antonio Finelli
This clinical guideline focuses on: 1) the use of multiparametric magnetic resonance imaging (mpMRI) in diagnosing clinically significant prostate cancer (CSPC) in patients with an elevated risk of CSPC and who are biopsy-naïve; and 2) the use of mpMRI in diagnosing CSPC in patients with a persistently elevated risk of having CSPC and who have a negative transrectal ultrasound (TRUS)-guided systematic biopsy. The methods of the Practice Guideline Development Cycle were used. MEDLINE, EMBASE, the Cochrane Library (1997‒April 2014), main guideline websites, and relevant annual meeting abstracts (2011‒2014) were searched...
January 2017: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/28163032/impact-of-gleason-subtype-on-prostate-cancer-detection-using-multiparametric-mri-correlation-with-final-histopathology
#6
Matthew Truong, Gary Hollenberg, Eric Weinberg, Edward M Messing, Hiroshi Miyamoto, Thomas P Frye
PURPOSE: Our purpose was to determine whether Gleason pattern 4 architecture impacts tumor visibility on multiparametric (mpMRI) and correlate with final histopathology. MATERIALS AND METHODS: A total of 83 tumor foci were identified within 22 radical prostatectomy specimens from patients with a prior negative biopsy who underwent MR/US fusion biopsy followed by radical prostatectomy from January 2015-July 2016. A genitourinary pathologist re-reviewed tumor foci for Gleason architectural subtype...
February 2, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28139757/establishing-the-distribution-of-satellite-lesions-in-intermediate-and-high-risk-prostate-cancer-implications-for-focused-radiotherapy
#7
J V Hegde, D J Margolis, P-C Wang, R E Reiter, J Huang, M L Steinberg, M Kamrava
BACKGROUND: In focused radiotherapy for prostate cancer (PC), a full dose of radiation is delivered to the index lesion while reduced dose is delivered to the remaining prostate to reduce morbidity. As PC is commonly multifocal, we investigated whether baseline clinical characteristics or multiparametric magnetic resonance imaging (mpMRI) may be useful to predict the actual pathologic distribution of PC in men with intermediate- or high-risk PC, which may better inform how to deliver focused radiotherapy...
January 31, 2017: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/28124523/predictive-role-of-trimprob-associated-with-multiparametric-mri-in-the-diagnosis-of-prostate-cancer
#8
Gustavo Cardoso Guimaraes, Walter Henriques da Costa, Renato Almeida Rosa, Stênio Zequi, Ricardo Favaretto
OBJECTIVES: To evaluate the predictive value of TRIMprob test to detect prostate cancer (PCa) in patients referred to prostate biopsy (PB). MATERIAL AND METHODS: Patients with PSA <10ng/mL and rectal exam without findings suggestive of prostate cancer were selected for TRIMprob evaluation. Exam was performed by a single operator through transperineal approach. Patients admitted for the study were submitted to TRIMprob and multiparametric magnetic resonance (mpMRI) and posteriorly to PB...
January 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/28120144/predicting-prostate-tumour-location-from-multiparametric-mri-using-gaussian-kernel-support-vector-machines-a-preliminary-study
#9
Yu Sun, Hayley Reynolds, Darren Wraith, Scott Williams, Mary E Finnegan, Catherine Mitchell, Declan Murphy, Martin A Ebert, Annette Haworth
The performance of a support vector machine (SVM) algorithm was investigated to predict prostate tumour location using multi-parametric MRI (mpMRI) data. The purpose was to obtain information of prostate tumour location for the implementation of bio-focused radiotherapy. In vivo mpMRI data were collected from 16 patients prior to radical prostatectomy. Sequences included T2-weighted imaging, diffusion-weighted imaging and dynamic contrast enhanced imaging. In vivo mpMRI was registered with 'ground truth' histology, using ex vivo MRI as an intermediate registration step to improve accuracy...
January 24, 2017: Australasian Physical & Engineering Sciences in Medicine
https://www.readbyqxmd.com/read/28115952/salvage-high-dose-rate-brachytherapy-for-histologically-confirmed-macroscopic-local-relapsed-prostate-cancer-after-radical-prostatectomy
#10
David Buchser, Alfonso Gomez-Iturriaga, J Ignacio Rodriguez Melcon, Francisco Casquero, Roberto Llarena, Jon Cacicedo, Pedro Bilbao
PURPOSE: To evaluate the feasibility of the use of real-time magnetic resonance imaging (MRI)-transrectal ultrasound (TRUS) fusion guided high-dose-rate brachytherapy (HDR-BT) +/- external beam radiation therapy (EBRT) in patients with histologically-proven local relapse after radical prostatectomy. MATERIAL AND METHODS: We retrospectively reviewed 13 patients treated with real-time MRI-TRUS fusion HDR-BT for a local relapse of prostate cancer after radical surgery...
December 2016: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/28112222/color-coded-visualization-of-magnetic-resonance-imaging-multiparametric-maps
#11
Jakob Nikolas Kather, Anja Weidner, Ulrike Attenberger, Yannick Bukschat, Cleo-Aron Weis, Meike Weis, Lothar R Schad, Frank Gerrit Zöllner
Multiparametric magnetic resonance imaging (mpMRI) data are emergingly used in the clinic e.g. for the diagnosis of prostate cancer. In contrast to conventional MR imaging data, multiparametric data typically include functional measurements such as diffusion and perfusion imaging sequences. Conventionally, these measurements are visualized with a one-dimensional color scale, allowing only for one-dimensional information to be encoded. Yet, human perception places visual information in a three-dimensional color space...
January 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28086856/the-addition-of-a-sagittal-image-fusion-improves-the-prostate-cancer-detection-in-a-sensor-based-mri-ultrasound-fusion-guided-targeted-biopsy
#12
Karsten Günzel, Hannes Cash, John Buckendahl, Maximilian Königbauer, Patrick Asbach, Matthias Haas, Jörg Neymeyer, Stefan Hinz, Kurt Miller, Carsten Kempkensteffen
BACKGROUND: To explore the diagnostic benefit of an additional image fusion of the sagittal plane in addition to the standard axial image fusion, using a sensor-based MRI/US fusion platform. METHODS: During July 2013 and September 2015, 251 patients with at least one suspicious lesion on mpMRI (rated by PI-RADS) were included into the analysis. All patients underwent MRI/US targeted biopsy (TB) in combination with a 10 core systematic prostate biopsy (SB). All biopsies were performed on a sensor-based fusion system...
January 13, 2017: BMC Urology
https://www.readbyqxmd.com/read/28073197/detection-rate-for-significant-cancer-at-confirmatory-biopsy-in-men-enrolled-in-active-surveillance-protocol-20-cores-vs-30-cores-vs-mri-trus-fusion-prostate-biopsy
#13
Pietro Pepe, Sebastiano Cimino, Antonio Garufi, Giandomenico Priolo, Giorgio Ivan Russo, Raimondo Giardina, Giulio Reale, Michele Barbera, Paolo Panella, Michele Pennisi, Giuseppe Morgia
INTRODUCTION: The detection rate for significant prostate cancer of extended vs saturation vs mMRI/TRUS fusion biopsy was prospectively evaluated in men enrolled in active surveillance (AS) protocol. Mterials and methods: From May 2013 to September 2016 75 men aged 66 years (median) with very low risk PCa were enrolled in an AS protocol and elegible criteria were: life expectancy greater than 10 years, cT1C, PSA below 10 ng/ml, PSA density < 0.20, 2 < unilateral positive biopsy cores, Gleason score (GS) equal to 6, greatest percentage of cancer (GPC) in a core < 50%...
December 30, 2016: Archivio Italiano di Urologia, Andrologia
https://www.readbyqxmd.com/read/28073195/cognitive-zonal-fusion-biopsy-of-the-prostate-original-technique-between-target-and-saturation
#14
Andrea B Galosi, Guevar Maselli, Giulia Sbrollini, Gaetano Donatelli, Lorenzo Montesi, Matteo Tallè, Rodolfo Montironi
: We describe our experience in prostate biopsy using a new standardized cognitive fusion techniques, that we call "cognitive zonal fusion biopsy". This new technique is based on two operative options: the first based on target biopsies, the Cognitive Target Biopsy (CTB) if the same target was detected with transrectal ultrasound (TRUS) and multiparametric magnetic resonance (mpMRI); the second based on saturation biopsies, the Zonal Saturation Biopsy (ZSB) on anatomical zone/s containing the region of interest if the same target was not evident with TRUS and MRI...
December 30, 2016: Archivio Italiano di Urologia, Andrologia
https://www.readbyqxmd.com/read/28047097/we-fg-206-09-association-of-prostate-volumes-with-restricted-diffusion-and-prostate-cancer-aggressiveness
#15
Y Tschudi
PURPOSE: To create an automatic workflow for evaluation of thresholds of restricted diffusion, based on Apparent Diffusion Coefficient (ADC) values in multiparametric (mp)MRI of the prostate. To investigate the association of these volumes with biopsy Gleason Score (GS). METHODS: Patients with prostate cancer, imaged on 3T Discovery MR750 (GE, Waukesha, WI) magnet were selected from departmental database based on the presence of mpMRI exam. All subsequent analyses were performed using Java plugins in MIM (MIM, Cleveland, Ohio)...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046902/su-d-207a-03-potential-role-of-bold-mri-in-discrimination-of-aggressive-tumor-habitat-in-prostate-cancer
#16
J Ford, C Lopez, Y Tschudi, A Breto, K Padgett, A Pollack, R Stoyanova
PURPOSE: To determine whether blood oxygenation level dependent (BOLD) MRI signal measured in prostate cancer patients, in addition to quantitative diffusion and perfusion parameters from multiparametric (mp)MRI exams, can help discriminate aggressive and/or radioresistant lesions. METHODS: Several ongoing clinical trials in our institution require mpMRI exam to determine eligibility (presence of identifiable tumor lesion on mpMRI) and prostate volumes for dose escalation...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28042330/comparison-of-68-ga-hbed-cc-psma-pet-ct-and-multiparametric-mri-for-gross-tumour-volume-detection-in-patients-with-primary-prostate-cancer-based-on-slice-by-slice-comparison-with-histopathology
#17
Constantinos Zamboglou, Vanessa Drendel, Cordula A Jilg, Hans C Rischke, Teresa I Beck, Wolfgang Schultze-Seemann, Tobias Krauss, Michael Mix, Florian Schiller, Ulrich Wetterauer, Martin Werner, Mathias Langer, Michael Bock, Philipp T Meyer, Anca L Grosu
PURPOSE: The exact detection and delineation of the intraprostatic tumour burden is crucial for treatment planning in primary prostate cancer (PCa). We compared (68)Ga-HBED-CC-PSMA PET/CT with multiparametric MRI (mpMRI) for diagnosis and tumour delineation in patients with primary PCa based on slice by slice correlation with histopathological reference material. METHODOLOGY: Seven patients with histopathologically proven primary PCa underwent (68)Ga-HBED-CC-PSMA PET/CT and MRI followed by radical prostatectomy...
2017: Theranostics
https://www.readbyqxmd.com/read/28005230/comparison-of-free-hand-transperineal-mpmri-trus-fusion-guided-biopsy-with-transperineal-12-core-systematic-biopsy-for-the-diagnosis-of-prostate-cancer-a-single-center-prospective-study-in-china
#18
Qing Zhang, Wei Wang, Bing Zhang, Jong Shi, Yao Fu, Danyan Li, Suhan Guo, Shengjie Zhang, Haifeng Huang, Xuping Jiang, Weimin Zhou, Hongqian Guo
OBJECTIVES: To prospectively compare biopsy outcomes between free-hand transperineal mpMRI/TRUS fusion targeted biopsy (TB) and transperineal systematic biopsy (SB) in patients with first prostate biopsy. PATIENTS AND METHODS: In all, 224 consecutive patients with the suspicion of PCa were investigated. All patients were evaluated by 3.0-T mpMRI applying the ESUR criteria. All patients underwent free-hand transperineal mpMRI/TRUS fusion TB and additionally a transperineal SB...
December 22, 2016: International Urology and Nephrology
https://www.readbyqxmd.com/read/28002239/feasibility-of-multiparametric-magnetic-resonance-imaging-of-the-prostate-at-7-t
#19
Miriam W Lagemaat, Bart W J Philips, Eline K Vos, Mark J van Uden, Jurgen J Fütterer, Sjoerd F Jenniskens, Tom W J Scheenen, Marnix C Maas
OBJECTIVES: The aim of this study was to evaluate the technical feasibility of prostate multiparametric magnetic resonance imaging (mpMRI) at a magnetic field strength of 7 T. MATERIALS AND METHODS: In this prospective institutional review board-approved study, 14 patients with biopsy-proven prostate cancer (mean age, 65.2 years; median prostate-specific antigen [PSA], 6.2 ng/mL), all providing signed informed consent, underwent 7 T mpMRI with an external 8-channel body-array transmit coil and an endorectal receive coil between September 2013 and October 2014...
December 20, 2016: Investigative Radiology
https://www.readbyqxmd.com/read/27993093/effect-of-androgen-deprivation-therapy-on-intra-prostatic-tumour-volume-identified-on-18-f-choline-pet-ct-for-prostate-dose-painting-radiotherapy
#20
Joachim Chan, Antony Carver, John Nh Brunt, Sobhan Vinjamuri, Isabel Syndikus
OBJECTIVES: Prostate dose painting radiotherapy requires the accurate identification of dominant intra-prostatic lesions (DILs) to be used as boost volumes; these can be identified on multi-parametric MRI (mpMRI) or choline PET/CT. Planning scans are usually performed after 2-3 months of androgen deprivation therapy (ADT). We examine the effect of ADT on choline tracer uptake and boost volumes identified on choline PET/CT. METHODS: (18)F choline PET/CT were performed for dose painting radiotherapy planning in intermediate to high-risk prostate cancer patients...
December 20, 2016: British Journal of Radiology
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