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Borderline ovarian tumor

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https://www.readbyqxmd.com/read/29403162/intraoperative-cytology-of-ovarian-neoplasms-with-an-attempt-to-grade-epithelial-tumors
#1
Sangita Bohara, Shyama Jain, Nita Khurana, Darilin M Shangpliang, Swapnil Agarwal, Gauri Gandhi
Background: Intraoperative cytology (IOC) is a simple and quick technique with excellent preservation of cellular details. In the present study, we have evaluated the role of IOC by various methods of smear preparation and compared it with frozen section diagnosis. A scoring system was followed for epithelial tumors for characterization and grading on the basis of cellularity, pattern, nuclear, cytoplasmic features, and background details. Materials and Methods: The study was conducted during a time span of 2 years in total 48 cases of ovarian tumors...
January 2018: Journal of Cytology
https://www.readbyqxmd.com/read/29397916/-fertility-preservation-contraception-and-menopause-hormone-therapy-in-women-treated-for-rare-ovarian-tumors-guidelines-from-the-french-national-network-dedicated-to-rare-gynaecological-cancer
#2
REVIEW
Christine Rousset-Jablonski, Fréderic Selle, Elodie Adda-Herzog, François Planchamp, Lise Selleret, Christophe Pomel, Nathalie Chabbert-Buffet, Emile Daraï, Patricia Pautier, Florence Trémollières, Frederic Guyon, Roman Rouzier, Valérie Laurence, Nicolas Chopin, Cécile Faure-Conter, Enrica Bentivegna, Marie-Cécile Vacher-Lavenu, Catherine Lhomme, Anne Floquet, Isabelle Treilleux, Fabrice Lecuru, Sébastien Gouy, Elsa Kalbacher, Catherine Genestie, Thibault de la Motte Rouge, Gwenael Ferron, Mojgan Devouassoux-Shisheboran, Jean-Emmanuel Kurtz, Moise Namer, Florence Joly, Eric Pujade-Lauraine, Michael Grynberg, Denis Querleu, Philippe Morice, Anne Gompel, Isabelle Ray-Coquard
INTRODUCTION: Rare ovarian tumors include complex borderline ovarian tumors, sex-cord tumors, germ cell tumors, and rare epithelial tumors. Indications and modalities of fertility preservation, infertility management and contraindications for hormonal contraception or menopause hormone therapy are frequent issues in clinical practice. A panel of experts from the French national network dedicated to rare gynaecological cancers, and of experts in reproductive medicine and gynaecology have worked on guidelines about fertility preservation, contraception and menopause hormone therapy in women treated for ovarian rare tumors...
February 1, 2018: Bulletin du Cancer
https://www.readbyqxmd.com/read/29394168/low-grade-endometrioid-stromal-sarcoma-of-the-paratestis-a-novel-report-with-molecular-confirmation-of-jazf1-suz12-translocation
#3
Abbas Agaimy, Evgeny A Moskalev, Wera Weisser, Thorsten Bach, Florian Haller, Arndt Hartmann
Tumors with Müllerian-like serous or mucinous phenotypes originating in the testis and its adnexa are rare neoplasms that have been increasingly recognized in recent years. Cystadenomas with or without ovarian-type stroma, borderline tumors, and adenocarcinomas are the main documented types. Although a handful cases of putative endometrioid adenocarcinomas have been reported, to our knowledge no case of endometrial stromal-type neoplasm has ever been reported in the literature. A 59-year-old man presented with a 2 cm left intrascrotal mass that was found on sonographic examination to arise from the epididymal tail with prominent vascularization...
February 1, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29393455/decreased-eph-receptor%C3%A2-a1-expression-is-related-to-grade-in-ovarian-serous-carcinoma
#4
Yunfeng Jin, Yi Zou, Linling Wan, Mingming Lu, Ya Liu, Guoqin Huang, Jiandong Wang, Qinghua Xi
Eph receptor‑A1 (EphA1) was the first member of the erythropoietin producing hepatocellular carcinoma (Eph) family of receptor tyrosine kinases. Although the roles of EphA1 in the tumorigenesis of various human cancers have been investigated, few studies have focused on ovarian carcinoma. The present study aimed to explore the profile of EphA1 expression in ovarian carcinomas, to analyzed the association between EphA1 expression and clinicopathologic parameters, and to investigate the roles of overexpressed EphA1 in ovarian cancer cells...
January 31, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29383195/the-safety-of-fertility-and-ipsilateral-ovary-procedures-for-borderline-ovarian-tumors
#5
Tong Lou, Fang Yuan, Ying Feng, Shuzhen Wang, Huimin Bai, Zhenyu Zhang
Objective: To explore the optimal treatment options for women with borderline ovarian tumors (BOTs). Materials and Methods: The medical records of consecutive patients with BOTs in two academic institutions were retrospectively collected. The pertinent data, including clinicopathological characteristics and, treatment and prognostic information were evaluated. Results: A total of 281 cases of BOTs were included in this analysis. For the entire series, the 5- year disease-free survival (DFS) and overall survival (OS) rates were 91...
December 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29374695/low-expression-of-cd44-is-an-independent-factor-of-poor-prognosis-in-ovarian-mucinous-carcinoma
#6
Hiroko Matuura, Morikazu Miyamoto, Masashi Takano, Hiroaki Soyama, Tadashi Aoyama, Tomoyuki Yoshikawa, Kento Kato, Takahiro Sakamoto, Mika Kuwahara, Kazuki Takasaki, Hiroki Ishibashi, Hideki Iwahashi, Hitoshi Tsuda, Kenichi Furuya
AIM: To determine whether CD44, which is associated with tumor growth and metastasis, is related to carcinogenesis and prognosis in ovarian mucinous carcinomas (MACs). MATERIALS AND METHODS: Tissue blocks from 71 patients with benign mucinous ovarian tumors were used in the study: 35 were from patients with borderline mucinous ovarian tumors, and 60 from patients with MACs. Immunochemical analysis was performed to evaluate the expression of CD44 and examine its association with tumorigenesis and survival...
February 2018: Anticancer Research
https://www.readbyqxmd.com/read/29373916/intra-operative-frozen-sections-for-ovarian-tumors-%C3%A2-a-tertiary-center-experience
#7
Nur Zaiti Md Arshad, Beng Kwang Ng, Noor Asmaliza Md Paiman, Zaleha Abdullah Mahdy, Rushdan Mohd Noor
Background: Accuracy of diagnosis with intra-operative frozen sections is extremely important in the evaluation of ovarian tumors so that appropriate surgical procedures can be selected. Study design: All patients who with intra-operative frozen sections for ovarian masses in a tertiary center over nine years from June 2008 until April 2017 were reviewed. Frozen section diagnosis and final histopathological reports were compared. Main outcome measures: Sensitivity, specificity, positive and negative predictive values of intra-operative frozen section as compared to final histopathological results for ovarian tumors...
January 27, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/29367766/pten-loss-in-the-fallopian-tube-induces-hyperplasia-and-ovarian-tumor-formation
#8
Angela Russo, Austin A Czarnecki, Matthew Dean, Dimple A Modi, Daniel D Lantvit, Laura Hardy, Seth Baligod, David A Davis, Jian-Jun Wei, Joanna E Burdette
The signaling events involved in the onset of ovarian cancer from the fallopian tube epithelium (FTE) are crucial for early detection and treatment of the disease, but they remain poorly defined. Conditional homozygous knockout of PTEN mediated by PAX8-cre recombinase was sufficient to drive endometrioid and serous borderline ovarian carcinoma, providing the first model of FTE-derived borderline tumors. In addition, heterozygous PTEN deletion in the FTE resulted in hyperplasia, providing a model to study early events of human ovarian pathogenesis...
January 25, 2018: Oncogene
https://www.readbyqxmd.com/read/29325322/-a-retrospective-study-of-tumor-and-fertility-outcomes-after-fertility-sparing-surgical-treatment-of-patients-with-borderline-ovarian-tumors
#9
F Liu, D H Hu, Y F Zhang, B Wang, K Huang, C Y Wang, X Y Xia
Objective: To study tumors and fertility outcomes after fertility-sparing surgical treatment with borderline ovarian tumors (BOT). Methods: One hundred and nineteen patients with BOT enrolled from 3 hospitals between January 2004 and January 2017 were analysed retrospectively.The clinical data and follow-up results were obtained and analyzed. Results: Among the 119 BOT patients, 55 patients underwent fertility-sparing surgery.The median age was 43 years (interquartile range: 15-80 years). There were 103 patients (86...
December 19, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29324543/short-term-outcomes-and-pregnancy-rate-after-laparoscopic-fertility-sparing-surgery-for-borderline-ovarian-tumors-a-single-institute-experience
#10
Jianguo Zhao, Caiyan Liu, Jing Liu, Pengpeng Qu
OBJECTIVE: We investigated the short-term outcomes and pregnancy rate after a laparoscopic approach to fertility preservation in patients with borderline ovarian tumors (BOTs). METHODS: Clinic-pathologic variants of patients with BOTs who underwent conservative surgery at the Tianjin Central Hospital of Obstetrics and Gynecology between January 2009 and July 2015 were retrospectively analyzed. RESULTS: Among 211 patients with BOTs, 74 (35...
January 10, 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29321056/mri-appearance-of-ovarian-serous-borderline-tumors-of-the-micropapillary-type-compared-to-that-of-typical-ovarian-serous-borderline-tumors-radiologic-pathologic-correlation
#11
Go Nakai, Takashi Yamada, Kazuhiro Yamamoto, Yoshinobu Hirose, Masahide Ohmichi, Yoshifumi Narumi
BACKGROUND: Serous borderline tumor (SBT) of the micropapillary type (SBT-MP) became one of the major pathological SBT diagnoses in addition to typical SBT, and was also defined as "non-invasive" low-gradeserous carcinoma according to the World Health Organization (WHO) classification in 2014. In this study, we investigated the MRI appearance of SBT-MP compared to that of typical SBT in order to identify specific imaging features of SBT-MP that correspond to pathological findings. METHODS: MR images of 6 histologically proven ovarian SBT-MP in four patients and 14 typical SBT in ten patients were reviewed retrospectively...
January 10, 2018: Journal of Ovarian Research
https://www.readbyqxmd.com/read/29298171/expression-of-%C3%AE-v-tubulin-in-secretory-cells-of-the-fallopian-tube-epithelium-marks-cellular-atypia
#12
Deepti Mathew, Yanhua Wang, Anne Van Arsdale, Susan Band Horwitz, Hayley McDaid
OBJECTIVES: Class V Beta tubulin isotype (βV-tubulin) was recently found to have tissue-specific expression patterns in epithelial tissues with secretory function and aberrant expression in tumors. The aims of this pilot study were (a) to examine expression of βV-tubulin in the fallopian tube epithelium (FTE) of patients who underwent salpingectomy, (b) to characterize FTE atypia in high-risk patients with BRCA mutations, and (c) to determine expression of βV-tubulin in serous ovarian neoplasms...
January 3, 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29281007/safety-of-ovarian-tissue-transplantation-in-patients-with-borderline-ovarian-tumors
#13
Rossella Masciangelo, Chiara Bosisio, Jacques Donnez, Christiani A Amorim, Marie-Madeleine Dolmans
STUDY QUESTION: Is transplantation of cryopreserved ovarian tissue from patients with borderline ovarian tumors (BOTs) a safe procedure? SUMMARY ANSWER: BOT cells were found in frozen-thawed and xenografted ovarian tissue in 1 of 11 BOT patients. WHAT IS KNOWN ALREADY: The risk of reintroducing malignant cells upon ovarian tissue transplantation has been subject of debate for many years. Reimplantation of cryopreserved ovarian tissue from leukemia patients is unsafe, while results from studies of cryopreserved ovarian tissue from other forms of cancer, such as Hodgkin's lymphoma, are reassuring...
December 21, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29279152/mri-features-and-score-for-differentiating-borderline-from-malignant-epithelial-ovarian-tumors
#14
Yong Ai Li, Jin Wei Qiang, Feng Hua Ma, Hai Ming Li, Shu Hui Zhao
PURPOSE: To identify the MRI features of borderline epithelial ovarian tumors (BEOTs) and to differentiate BEOTs from malignant epithelial ovarian tumors (MEOTs). MATERIALS AND METHODS: The clinical and MRI data of 89 patients with a BEOT and 109 patients with a MEOT proven by surgery and histopathology were retrospectively reviewed. MRI features, including bilaterality, size, shape, margin, cystic-solid interface, configuration, papillae or nodules, signal intensity, enhancement, presence of an ipsilateral ovary, peritoneal implants and ascites were analyzed and compared...
January 2018: European Journal of Radiology
https://www.readbyqxmd.com/read/29250679/bilateral-serous-surface-papillary-borderline-ovarian-tumor-in-19-year-old-patient-ultrasound-immunohistochemical-and-therapeutic-particularities-of-reproductive-age
#15
Roxana Elena BohîlŢea, Nicolae Bacalbaşa, Natalia Ţurcan, Monica Mihaela Cîrstoiu, Dana Cristina Terzea, George Simion, Octavian Munteanu, Costin Berceanu, Elvira Brătilă
Borderline tumors have a histological aspect of atypical epithelial proliferation without stromal invasion and typically occur in fertile ages, approximately one-third of women diagnosed are younger than 40. Serous borderline tumors are the most encountered and they can present micropapillary features that are associated with a higher rate of recurrence and the possibility of peritoneal implants. We present the case of a serous borderline ovarian tumor in a young patient and the diagnosis and treatment particularities...
2017: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/29247577/ovarian-cancer-risk-aldh2-polymorphism-and-alcohol-drinking-asian-data-from-the-ovarian-cancer-association-consortium
#16
Tomotaka Ugai, Linda E Kelemen, Mika Mizuno, Jue-Sheng Ong, Penelope M Webb, Georgia Chenevix-Trench, Kristine G Wicklund, Jennifer Anne Doherty, Mary Anne Rossing, Pamela J Thompson, Lynne R Wilkens, Michael E Carney, Marc T Goodman, Joellen M Schildkraut, Andrew Berchuck, Daniel W Cramer, Kathryn L Terry, Hui Cai, Xiao-Ou Shu, Yu-Tang Gao, Yong-Bing Xiang, David Van Den Berg, Malcom C Pike, Anna H Wu, Celeste Leigh Pearce, Keitaro Matsuo
The ALDH2 polymorphism rs671 (Glu504Lys) causes ALDH2 inactivation and adverse acetaldehyde exposure among Asians, but little is known of the association between alcohol consumption and rs671 and ovarian cancer (OvCa) in Asians. We conducted a pooled analysis of Asian ancestry participants in the Ovarian Cancer Association Consortium. We included seven case-control studies and one cohort study comprising 460 invasive OvCa cases, 37 borderline mucinous OvCa and 1,274 controls of Asian descent with information on recent alcohol consumption...
December 16, 2017: Cancer Science
https://www.readbyqxmd.com/read/29241740/aberrant-pax-8-expression-in-well-differentiated-papillary-mesothelioma-and-malignant-mesothelioma-of-the-peritoneum-a-clinicopathologic-study
#17
Deyin Xing, Natalie Banet, Rajni Sharma, Russell Vang, Brigitte M Ronnett, Peter B Illei
Serous ovarian neoplasms can overlap morphologically with peritoneal mesothelial proliferations, with common features including well-differentiated papillary mesothelioma (WDPM) and malignant epithelioid mesothelioma (MM). Accurate histologic classification of these neoplasms is important for clinical management. The Pax-8 protein is commonly used for differentiating peritoneal MM from serous carcinoma, but the diagnostic value of Pax-8 for distinguishing WDPM from borderline or low-grade serous tumors is unknown...
December 11, 2017: Human Pathology
https://www.readbyqxmd.com/read/29236181/ultrasound-based-logistic-regression-model-lr2-versus-magnetic-resonance-imaging-for-discriminating-between-benign-and-malignant-adnexal-masses-a-prospective-study
#18
Kanane Shimada, Koji Matsumoto, Takashi Mimura, Tetsuya Ishikawa, Jiro Munechika, Yoshimitsu Ohgiya, Miki Kushima, Yusuke Hirose, Yuka Asami, Chiaki Iitsuka, Shingo Miyamoto, Mamiko Onuki, Hajime Tsunoda, Ryu Matsuoka, Kiyotake Ichizuka, Akihiko Sekizawa
BACKGROUND: The diagnostic performances of the International Ovarian Tumor Analysis (IOTA) ultrasound-based logistic regression model (LR2) and magnetic resonance imaging (MRI) in discriminating between benign and malignant adnexal masses have not been directly compared in a single study. METHODS: Using the IOTA LR2 model and subjective interpretation of MRI findings by experienced radiologists, 265 consecutive patients with adnexal masses were preoperatively evaluated in two hospitals between February 2014 and December 2015...
December 13, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29203995/management-of-borderline-ovarian-tumors-still-a-gray-zone
#19
Nidhi Nayyar, Prerna Lakhwani, Ashish Goel, Pankaj Kr Pande, Kapil Kumar
Borderline ovarian tumors (BOTs) are a heterogeneous group of non-invasive epithelial ovarian tumors that occur at a younger age, present in early stage, frequently associated with infertility but are easily curable. Although they may have symptomatic long-term recurrences, they have an excellent prognosis in spite of peritoneal spread. Among the epithelial tumors of the ovary, BOTs fall in the spectrum lying between cystadenomas (benign) and cystadenocarcinomas (malignant). Their oncological behavior is more aggressive than benign ovarian tumors but relatively less than that of malignant ovarian tumors...
December 2017: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29197420/ovarian-mucinous-borderline-tumor-accompanied-by-lgess-with-myxoid-change-a-case-report-and-literature-review
#20
Wen Wang, Yalin Zhuang, Feng Zhou, Lili Huang
OBJECTIVES: To report an extremely rare case of ovarian borderline mucinous cystic tumor accompanied by low-grade endometrial stromal sarcoma (LGESS) with myxoid change. CASE PRESENTATION: A 42-year-old woman complained of lower left abdominal fullness. Her serum carcinoembryonic antigen, cancer antigen (CA) 125, and CA19-9 levels were normal. Magnetic resonance imaging showed a 10-cm cystic mass with a 5-cm nodule in its wall, and a laparoscopy indicated a cystic mass at the left adnexa...
December 2, 2017: European Journal of Medical Research
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