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Borderline ovarian tumor

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https://www.readbyqxmd.com/read/29929922/combined-symptom-index-and-second-generation-multivariate-biomarker-test-for-prediction-of-ovarian-cancer-in-patients-with-an-adnexal-mass
#1
Renata R Urban, Todd C Pappas, Rowan G Bullock, Donald G Munroe, Vinicius Bonato, Kathy Agnew, Barbara A Goff
OBJECTIVE: To assess the performance of a symptom index (SI) and multivariate biomarker panel in the identification of ovarian cancer in women presenting for surgery with an adnexal mass. STUDY DESIGN: Prospective study of patients seen at a tertiary medical center. Following consent, patients completed an SI and preoperative serum was collected for individual markers (CA 125) and a second-generation FDA-cleared biomarker test (MIA2G). Results for the SI and MIA2G were correlated with operative findings and surgical pathology...
June 18, 2018: Gynecologic Oncology
https://www.readbyqxmd.com/read/29928400/genetic-analysis-and-phosphoinositide-3-kinase-protein-kinase-b-signaling-pathway-status-in-ovarian-endometrioid-borderline-tumor-samples
#2
Kohei Nakamura, Kentaro Nakayama, Masako Ishikawa, Toshiko Minamoto, Tomoka Ishibashi, Emi Sato, Kaori Sanuki, Hitomi Yamashita, Ruriko Ono, Kouji Iida, Razia Sultana, Mohammad Mahmud Hossain, Noriyoshi Ishikawa, Satoru Kyo
Ovarian endometrioid borderline tumors (EBTs) are extremely rare, and are thought to be precursors of endometrioid carcinoma, beginning as adenofibroma or endometriosis and progressing in a slow, stepwise manner. In endometrioid carcinomas, a high frequency of activating mutations in phosphatase and tensin homolog ( PTEN ), β-catenin or AT-rich interaction domain 1A ( ARID1A ) genes, and the activation of the phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT) signaling pathway have been observed. However, the frequency of these alterations in EBTs and how they contribute to tumor progression remain unclear...
July 2018: Oncology Letters
https://www.readbyqxmd.com/read/29892146/upregulation-of-endothelin-1-endothelin-a-receptor-expression-correlates-with-heparanase-expression-in-ovarian-carcinoma
#3
Nungki Anggorowati, Ahmad Ghozali, Irianiwati Widodo, Dwi Cahyani Ratna Sari, Muhammad Mansyur Romi, Nur Arfian
Background: Heparanase and endothelin-1/endothelin A receptor (ET-1/ETA R) expressions increase in cancer. This condition enhances tumor progression and correlates with poor survival. Limited data are documented regarding the role of heparanase and ET-1/ETA R in epithelial ovarian cancer (EOC). We sought to characterize the correlation between heparanase and ET-1/ETA R in EOC. Methods: Thirty patients with benign and malignant ovarian neoplasms were recruited in this study...
May 2018: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29888983/ovarian-serous-surface-papillary-borderline-tumor-characteristic-imaging-features-with-clinicopathological-correlation
#4
Sung Bin Park, Min-Jeong Kim, Kyoung Ho Lee, Yousun Ko
OBJECTIVE: To retrospectively evaluate the clinical, pathological, and imaging features of ovarian serous surface papillary borderline tumors (SSPBTs). METHODS: Imaging features were analyzed, including the tumor size, laterality, tumor spread and the presence of ascites. Morphological nature (encased normal ovary, characteristics on MRI) and contrast enhancement (increased flow on Doppler US) were also evaluated. Clinical and pathological features, such as tumor markers (CA 125), treatment methods, outcomes on follow-up, and surgical staging, were analyzed...
June 11, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29795040/recent-insights-into-mucinous-ovarian-carcinoma
#5
REVIEW
Francesca Ricci, Roberta Affatato, Laura Carrassa, Giovanna Damia
Ovarian mucinous tumors represent a group of rare neoplasms with a still undefined cell of origin but with an apparent progression from benign to borderline to carcinoma. Even though these tumors are different from the other histological subtypes of epithelial ovarian neoplasms, they are still treated with a similar chemotherapeutic approach. Here, we review its pathogenesis, molecular alterations, (differential) diagnosis, clinical presentation and current treatment, and how recent molecular and biological information on this tumor might lead to better and more specific clinical management of patients with mucinous ovarian carcinoma...
May 24, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29783796/-standardization-for-diagnostic-tumor-pathology-ovarian-carcinoma-and-borderline-epithelial-neoplasm
#6
(no author information available yet)
No abstract text is available yet for this article.
May 8, 2018: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/29709594/reliability-of-iota-score-and-adnex-model-in-the-screening-of-ovarian-malignancy-in-postmenopausal-women
#7
Erdogan Nohuz, Luisa De Simone, Gautier Chêne
BACKGROUND: The IOTA (International Ovarian Tumor Analysis) group has developed the ADNEX (Assessment of Different NEoplasias in the adneXa) model to predict the risk that an ovarian mass is benign, borderline or malignant. This study aimed to test reliability of these risks prediction models to improve the performance of pelvic ultrasound and discriminate between benign and malignant cysts. MATERIAL AND METHODS: Postmenopausal women with an adnexal mass (including ovarian, para-ovarian and tubal) and who underwent a standardized ultrasound examination before surgery were included...
April 28, 2018: Journal of Gynecology Obstetrics and Human Reproduction
https://www.readbyqxmd.com/read/29709486/preservation-of-fertility-in-surgery-of-benign-and-borderline-malignant-ovarian-tumors
#8
A Guillaume, O Pirrello
Benign ovarian tumors occur in 7% of women during their procreative years and involve both organic and functional tumors. The average age of onset for borderline ovarian tumors is ten years younger than that for ovarian cancers. Women with benign and borderline malignant ovarian tumors are therefore more likely to be affected by fertility issues. The causal link between infertility and benign ovarian tumor stems more from the therapeutic strategies adopted than from the histological nature of the benign ovarian tumor...
June 2018: Journal of Visceral Surgery
https://www.readbyqxmd.com/read/29682098/testing-for-nras-mutations-in-serous-borderline-ovarian-tumors-and-low-grade-serous-ovarian-carcinomas
#9
Pawel Sadlecki, Dariusz Grzanka, Marek Grabiec
The Idylla NRAS Mutation Test , performed on the Biocartis Idylla system, is an in vitro diagnostic tool for the qualitative assessment of 18 NRAS mutations in codons 12, 13, 59, 61, 117, and 146. Low-grade serous ovarian cancer (LGSC) represents less than 10% of all serous ovarian carcinomas. LGSCs are believed to arise from preexisting cystadenomas or serous borderline tumors (SBOTs) that eventually progress to an invasive carcinoma. The molecular analysis of cancer-causing mutations and the development of targeted biological therapies constitute a milestone in the diagnosis and therapy of ovarian malignancies...
2018: Disease Markers
https://www.readbyqxmd.com/read/29680231/accuracy-of-intraoperative-frozen-section-diagnosis-of-borderline-ovarian-tumors-by-hospital-type
#10
Jaimin S Shah, Michael Mackelvie, David M Gershenson, Preetha Ramalingam, Marylee M Kott, Jubilee Brown, Polly Gauthier, Elizabeth Nugent, Lois M Ramondetta, Michael Frumovitz
STUDY OBJECTIVE: To compare the accuracy of frozen section diagnosis of borderline ovarian tumors among 3 distinct types of hospital-academic hospital with gynecologic pathologists, academic hospital with nongynecologic pathologists, and community hospital with nongynecologic pathologists-and to determine if surgical staging alters patient care or outcomes for women with a frozen section diagnosis of borderline ovarian tumor. DESIGN: Retrospective study (Canadian Task Force classification II-1)...
April 19, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29676373/ovarian-borderline-mucinous-tumor-with-squamous-overgrowth-an-unusual-finding-with-review-of-literature
#11
Geetha Vasudevan, Padmapriya Jaiprakash, Shyamala Guruvare, Nivedita Samanta
Borderline mucinous tumor (BMT) is often associated with other entities such as dermoid cyst, Brenner tumor, and endometriosis. Squamous areas are often associated which may be a part of BMT or its associated conditions. Here, we describe squamous overgrowth in a case of intestinal type of mucinous borderline tumor in a 29-year-old uniparous female and discuss the diagnostic difficulties.
April 2018: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/29673382/risk-of-synchronous-endometrial-disorders-in-women-with-endometrioid-borderline-tumors-of-the-ovary
#12
Shuang-Zheng Jia, Jun-Ji Zhang, Jun-Jun Yang, Yang Xiang, Zhiyong Liang, Jin-Hua Leng
BACKGROUND: Synchronous endometrial disorders have been poorly studied in women with endometrioid borderline ovarian tumors (EBOT). The aims of this study were to investigate the risk of endometrial disorders among women with EBOT and associated factors, as well as their oncological and fertility outcomes. RESULTS: This retrospective study included 33 women with EBOT. Their mean age was 41.9 years, and endometria were evaluated in 25 of these patients. The prevalence of synchronous endometrial disorders was 52...
April 19, 2018: Journal of Ovarian Research
https://www.readbyqxmd.com/read/29593930/mucinous-carcinomatosis-a-rare-association-between-an-ovarian-tumor-and-an-e-gist
#13
Hugo Palma Rios, André Goulart, Pedro Leão
Pseudomyxoma peritonei (PMP) and extragastrointestinal stromal tumors (E-GISTs) are both rare entities. Most of the time, PMP is associated with an appendiceal tumor. An ovarian mucinous tumor can mimic appendiceal metastases. E-GIST is a mesenchymal tumor that can arise from the omentum, retroperitoneum, mesentery, or pleura. We present a case of an 87-year-old woman with mucinous carcinomatosis and acute intestinal occlusion submitted to an emergency laparotomy. She has found to have a borderline mucinous tumor of the ovary from the intestinal type with several lesions of pseudomyxoma peritonei and an E-GIST from the epiploons retrocavity (intermediated risk)...
2018: Case Reports in Surgery
https://www.readbyqxmd.com/read/29581788/increased-he4-mrna-expression-correlates-with-high-level-of-eif3a-mrna-and-better-survival-in-women-with-epithelial-ovarian-cancer
#14
Chen-Hui Luo, Min Zhao, Yu-Xi Tang, Shohreh Shahabi, Kai-Ning Fang, Yan Chen, Yan Tang, Xiao-Yan Chen, Jing Wang, Hong-Hao Zhou
Human epididymis protein 4 (HE4) is one of the most promising biomarkers for epithelial ovarian cancer (EOC). The majority of previous studies utilized the serum level or tissue protein expression of HE4 based upon immunohistochemistry (IHC) to evaluate the role of HE4 in the diagnosis, prognosis, and surveillance of EOC, but very little is known about HE4 mRNA expression. Eukaryotic translation initiation factor 3a (eIF3a) is implicated in oncogenesis and has been investigated extensively as a potential biomarker for malignancy...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29571946/nilotinib-in-locally-advanced-pigmented-villonodular-synovitis-a-multicentre-open-label-single-arm-phase-2-trial
#15
Hans Gelderblom, Claire Cropet, Christine Chevreau, Richard Boyle, Martin Tattersall, Silvia Stacchiotti, Antoine Italiano, Sophie Piperno-Neumann, Axel Le Cesne, Virginia Ferraresi, Nicolas Penel, Florence Duffaud, Philippe Cassier, Maud Toulmonde, Paolo Casali, Sophie Taieb, Séverine Guillemaut, Séverine Metzger, David Pérol, Jean-Yves Blay
BACKGROUND: Pigmented villonodular synovitis (alternatively known as diffuse-type giant cell tumour) is a rare, locally aggressive tumour driven by a specific translocation resulting in the overexpression of colony-stimulating factor 1 (CSF1). CSF1 receptor (CSF1R) inhibitors (ie, tyrosine kinase inhibitors and antibodies) induce a response in patients with pigmented villonodular synovitis. We investigated the safety and efficacy of a CSF1R tyrosine kinase inhibitor, nilotinib, in patients with locally advanced non-resectable pigmented villonodular synovitis...
May 2018: Lancet Oncology
https://www.readbyqxmd.com/read/29556691/quantitative-dynamic-contrast-enhanced-mr-imaging-for-differentiating-benign-borderline-and-malignant-ovarian-tumors
#16
Hai-Ming Li, Feng Feng, Jin-Wei Qiang, Guo-Fu Zhang, Shu-Hui Zhao, Feng-Hua Ma, Yong-Ai Li, Wei-Yong Gu
PURPOSE: This study aimed to investigate the diagnostic performance of quantitative DCE-MRI for characterizing ovarian tumors. METHODS: We prospectively assessed the differences of quantitative DCE-MRI parameters (Ktrans , kep , and ve ) among 15 benign, 28 borderline, and 66 malignant ovarian tumors; and between type I (n = 28) and type II (n = 29) of epithelial ovarian carcinomas (EOCs). DCE-MRI data were analyzed using whole solid tumor volume region of interest (ROI) method, and quantitative parameters were calculated based on a modified Tofts model...
March 20, 2018: Abdominal Radiology
https://www.readbyqxmd.com/read/29552194/activation-of-hedgehog-signaling-and-its-association-with-cisplatin-resistance-in-ovarian-epithelial-tumors
#17
Xueling Song, Liying Yan, Cuiling Lu, Chunyu Zhang, Fuli Zhu, Jingjing Yang, Hongyan Jing, Yang Zhang, Jie Qiao, Hongyan Guo
Few studies have evaluated Hedgehog (Hh) signaling pathway activation in different types of ovarian tumors including benign, borderline and malignant ovarian tumors. The present study investigated the expression of Hh signaling pathway components (SHH, SMO, PTCH, and GLI1) in 193 ovarian epithelial tumor specimens (including 147 malignant epithelial ovarian cancers, 30 borderline ovarian tumors, 16 benign ovarian epithelial tumors) and 11 normal ovarian epithelial tissues by immunohistochemistry. The results demonstrated widespread expression of Hh pathway molecules in ovarian tumors...
April 2018: Oncology Letters
https://www.readbyqxmd.com/read/29551085/ovarian-clear-cell-adenofibroma-of-low-malignant-potential-developing-into-clear-cell-adenocarcinoma
#18
Zhiwei Yin, Stephen Peters, Ravi Chokshi, Debra Heller
Ovarian clear cell adenofibroma is uncommon, and borderline clear cell adenofibroma (low malignant potential) is extremely rare. Borderline clear cell adenofibromas may represent the precursor lesion of clear cell adenocarcinoma of the ovary, but this has not been established. We present a case of a woman in her mid-50s with a clear cell adenofibroma ranging from benign to borderline to frankly invasive. While some clear cell adenocarcinomas are thought to arise from endometriosis, this range of findings supports the theory that some ovarian clear cell adenocarcinomas originate from borderline tumors...
March 1, 2018: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29545041/testis-tumor-of-ovarian-epithelial-type-a-rare-case
#19
Kamleshsingh Shadhu, Dadhija Ramlagun, Kai Zhu, Yao Zhang, Chen Chen, Di Xi, Jundong Zhu, Chenkui Miao, Yichun Wang, Chao Qin
Ovarian epithelial type tumors of the testis have been a rare clinical entity. Its awareness and management remain a clinical challenge. We described the case of an 18-year-old, obese male patient who presented with scrotal enlargement. He underwent eversion of tunica vaginalis and resection of epididymal mass. The histology of the resected sample showed an ovarian epithelial type borderline tumor. We believe our case helps to strengthen awareness and management of this rare disease.
May 2018: Urology
https://www.readbyqxmd.com/read/29520665/report-of-the-survey-on-current-opinions-and-practice-of-german-society-for-gynecologic-endoscopy-age-members-regarding-the-laparoscopic-treatment-of-ovarian-malignancies
#20
Julia Caroline Radosa, Marc Philipp Radosa, Pascal Albert Schweitzer, Ingolf Juhasz-Boess, Stefan Rimbach, Erich-Franz Solomayer
PURPOSE: The purpose of this survey was to assess the opinions of members of the German Society of Gynecologic Endoscopy (AGE) regarding the laparoscopic treatment of ovarian malignancies and current practice at their institutions. METHODS: Between February and October 2015, the AGE sent an anonymous online survey via mail to its members. The questionnaire solicited participants' opinions about the laparoscopic treatment of ovarian cancers according to T stage and borderline tumors, and information about current practice at their institutions...
May 2018: Archives of Gynecology and Obstetrics
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