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Philipp Riffel, Holger Haubenreisser, Kai Higashigaito, Hatem Alkadhi, John N Morelli, Bettina Alber, Stefan O Schoenberg, Thomas Henzler
PURPOSE: To compare in patients with known peripheral artery occlusive disease (PAOD), image quality of a combined CTA to a combined MRA protocol, including both static and dynamic acquisitions. MATERIALS AND METHODS: Twenty-two patients with PAOD were examined with a combined CTA and MRA protocol consisting of static acquisitions (s-CTA, s-MRA) of the entire runoff and dynamic acquisitions (d-CTA, d-MRA) of the calves. Two radiologists compared image quality of the s-MRA versus s-CTA as well as d-MRA versus d-CTA...
February 26, 2018: Cardiovascular and Interventional Radiology
Jan Neumann, Christoph Schmaderer, Sebastian Finsterer, Alexander Zimmermann, Dominik Steubl, Anne Helfen, Markus Berninger, Fabian Lohöfer, Ernst J Rummeny, Reinhard Meier, Moritz Wildgruber
BACKGROUND: Quantitative Imaging of microcirculatory disorders is challenging. OBJECTIVE: To investigate the feasibility of 2D Fluorescence Optical Imaging (FOI) for characterization and quantification of microcirculatory disorders in peripheral arterial occlusive disease (PAOD) of the upper extremity. METHODS: 9 patients with various clinical presentations of PAOD of the upper extremity were included. Quantitative analysis of both hands was performed by assessing the fluorescence intensity of Indocyanine Green (ICG) dynamically over a time period of 360 seconds...
February 2, 2018: Clinical Hemorheology and Microcirculation
Po-Chao Hsu, Wen-Hsien Lee, Hsiang-Chun Lee, Wei-Chung Tsai, Chun-Yuan Chu, Ying-Chih Chen, Chee-Siong Lee, Tsung-Hsien Lin, Wen-Chol Voon, Sheng-Hsiung Sheu, Ho-Ming Su
The ankle-brachial index (ABI) is a reliable diagnostic examination for peripheral arterial occlusive disease (PAOD). We previously reported CHADS2 score was significantly correlated with PAOD. However, the association between CHA2DS2-VASc score and ABI < 0.9 is not evaluated in the literature. The aim of the present study was to investigate whether CHA2DS2-VASc score has a strong association with PAOD. We enrolled 1482 patients in this study. PAOD was defined as ABI < 0.9 in either leg. Vascular disease in CHA2DS2-VASc score was modified as vascular disease except PAOD...
January 19, 2018: Scientific Reports
Valeria Vietto, Juan Va Franco, Victoria Saenz, Denise Cytryn, Jose Chas, Agustín Ciapponi
BACKGROUND: Peripheral arterial occlusive disease (PAOD) is a common cause of morbidity and mortality due to cardiovascular disease in the general population. Although numerous treatments have been adopted for patients at different disease stages, no option other than amputation is available for patients presenting with critical limb ischaemia (CLI) unsuitable for rescue or reconstructive intervention. In this regard, prostanoids have been proposed as a therapeutic alternative, with the aim of increasing blood supply to the limb with occluded arteries through their vasodilatory, antithrombotic, and anti-inflammatory effects...
January 10, 2018: Cochrane Database of Systematic Reviews
Thanawat Rattanathammethee, Adisak Tantiworawit, Ekarat Rattarittamrong, Chatree Chai-Adisaksopha, Sasinee Hantrakool, Arintaya Phrommintikul, Wanwarang Wongcharoen, Siriluck Gunaparn, Lalita Norasetthada
Background: There were some reports of peripheral artery occlusive disease (PAOD) associated with nilotinib usage in chronic myeloid leukemia (CML). These complications in other tyrosine kinase inhibitors are revealed as unknown. Materials and methods: We determined the prevalence of PAOD in patients with CML as compared with matched-control population by cross-sectional case-control study. Peripheral artery occlusive disease was screened by ankle-brachial index (ABI)...
2017: Clinical Medicine Insights. Cardiology
Li-Syue Liou, Chih-Ya Chang, Hsuan-Ju Chen, Chun-Hung Tseng, Cheng-Yu Chen, Fung-Chang Sung
OBJECTIVE: This population-based cohort study investigated the risk of developing peripheral arterial occlusive disease (PAOD) in patients with Bell's palsy. METHODS: We used longitudinal claims data of health insurance of Taiwan to identify 5,152 patients with Bell's palsy newly diagnosed in 2000-2010 and a control cohort of 20,608 patients without Bell's palsy matched by propensity score. Incidence and hazard ratio (HR) of PAOD were assessed by the end of 2013...
2017: PloS One
Tariq S Marroush, Andrew R Boshara, Kesav C Parvataneni, Robert Takla, Nancy A Mesiha
Painless aortic dissection (PAoD) has been previously linked to poor outcomes. We recently encountered a case of a patient with PAoD presenting with dyspnea; the clue to diagnosis was the presence of a loud aortic diastolic murmur. A systematic review of the literature revealed 86 other cases, 62% of which occurred in men with a mean age of 65 years. Left-sided neurologic deficits were the most common presentation, followed by dyspnea and bilateral lower extremity deficits. Pulse asymmetry was found in 53% of patients, as 29% had right-left asymmetry and 24% had upper-lower asymmetry...
November 2017: American Journal of the Medical Sciences
U Barth, K Wasseroth, F Meyer
INTRODUCTION: A material-associated true aneurysm after previous use of a vascular prosthesis for arterial reconstruction mostly in peripheral arterial occlusion disease (PAOD) is considered a rare but serious complication. AIM AND METHOD: The aim of the compact brief review was to describe the rare finding of a true aneurysm of a prosthesis and its diagnosis-specific care including a representative scientific case report, based on selected topic-related references from the medical literature as well as the specific experiences obtained from the successful clinical management in single cases...
October 25, 2017: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
Melody Glenn, Olivia Zoph, Kim Weidenaar, Leila Barraza, Warren Greco, Kylie Jenkins, Pooja Paode, Jonathan Fisher
BACKGROUND: Community Paramedicine (CP) is a rapidly evolving field within prehospital care where paramedics step outside of their traditional roles of treating acute conditions to provide elements of primary and preventive care. It is unclear if current state oversight regarding the scope of practice (SOP) for paramedics provides clear guidance on the novel functions provided and skills performed by CP programs. OBJECTIVE: To determine the process and authority, as currently defined by state laws and regulations in the United States, to expand paramedic SOP in order to perform CP roles and to assess state EMS agencies' interpretation of paramedic SOP as it applies to CP...
October 12, 2017: Prehospital Emergency Care
Matej Bendzala, Peter Sabaka, Martin Caprnda, Andrea Komornikova, Maria Bisahova, Ruth Baneszova, Daniel Petrovic, Robert Prosecky, Luis Rodrigo, Peter Kruzliak, Andrej Dukat
BACKGROUND: The blood concentrations of total cholesterol and low-density lipoprotein (LDL) do not predict survival in patients older than 60 years. The atherogenic index of plasma (AIP) is a logarithm of the triacylglycerol to high-density lipoprotein (HDL) ratio and a surrogate for the concentration of small dense LDL. It might be a better reflection of the risk of all-cause death in elderly patients. METHODS: We conducted a prospective observational study of patients with arterial hypertension older than 60 years...
November 2017: Wiener Klinische Wochenschrift
C-A Behrendt, F Heidemann, K Haustein, R T Grundmann, E S Debus
BACKGROUND: The percutaneous infrainguinal stent (PSI) register study aimed to collate all percutaneous endovascular procedures for infrainguinal peripheral arterial occlusive disease (PAOD) conducted in 74 German vascular centers between September and November 2015 (3 months). In order to obtain representative results all consecutive treatment procedures had to be submitted by the participating trial centers. MATERIAL AND METHODS: This was a prospective, nonrandomized multicenter study design...
2017: Gefässchirurgie: Zeitschrift Für Vaskuläre und Endovaskuläre Chirurgie
Gunnar Tepe, Özlem Gögebakan, Ulf Redlich, Jörg Tautenhahn, Jens Ricke, Zuhir Halloul, Dirk-Roelfs Meyer, Matthias Waliszewski, Beatrix Schnorr, Thomas Zeller, Stefan Müller-Hülsbeck, Ilka Ott, Thomas Albrecht
OBJECTIVES: Based on a novel paclitaxel-resveratrol drug matrix, the safety and efficacy to inhibit intimal hyperplasia were studied in symptomatic claudicants with morphologically challenging lesions. BACKGROUND: The treatment of peripheral artery occlusive disease (PAOD) with percutaneous transluminal angioplasty is limited by occurrence of vessel recoil and neointimal hyperplasia. Drug-coated balloons (DCB) deliver drugs to the arterial wall to potentially reduce the restenosis rate...
October 2017: Cardiovascular and Interventional Radiology
Juliane Herm, Berthold Hoppe, Bob Siegerink, Christian H Nolte, Jürgen Koscielny, Karl Georg Haeusler
BACKGROUND: While twin studies indicate a genetic component in arterial thrombosis such as ischemic stroke, myocardial infarction (MI), or peripheral arterial occlusive disease (PAOD), the clinical relevance of hemostatic polymorphisms in arterial thrombosis is a matter of debate. METHODS: We analyzed the prevalence of 13 hemostatic polymorphisms [PAI-1, PLAT, F5 (including factor V Leiden and HR2 haplotype), F2, F7, F13A, FGB, TFPI, THBD, MTHFR, ACE, and ITGA2] in patients referred to a tertiary referral center...
2017: Frontiers in Cardiovascular Medicine
Matthias W Waliszewski, Ulf Redlich, Victor Breul, Jörg Tautenhahn
BACKGROUND: The aim of this review is to present the available clinical and surrogate endpoints that may be used in future studies performed in patients with peripheral artery occlusive disease (PAOD). Importantly, we describe statistical limitations of the most commonly used endpoints and offer some guidance with respect to study design for a given sample size. The proposed endpoints may be used in studies using surgical or interventional revascularization and/or drug treatments. METHODS: Considering recently published study endpoints and designs, the usefulness of these endpoints for reimbursement is evaluated...
April 30, 2017: Polski Przeglad Chirurgiczny
Cheng-San Yang, Yu-Shan Wei, Han-Lin Tsai, Ian-Seng Cheong, Shing-Jyh Chang, Hsiu-Chuan Chou, Ying-Ray Lee, Hong-Lin Chan
Peripheral arterial occlusive disease (PAOD), one of the major manifestations of systemic atherosclerosis, causes intermittent claudication and rest pain. Patients with PAOD not only have reduced quality of life, but also have a substantial risk of cardiovascular morbidity and death. In this study, we adopted a proteomics-based approach using 2D-DIGE and MALDI-TOF MS to compare the differential plasma proteome between good and poor prognosis of PAOD. We identified 196 plasma proteins, which represent 42 unique gene products...
June 27, 2017: Molecular BioSystems
Anne Humeau-Heurtier, Pierre Abraham, Samir Henni
The number of patients suffering from peripheral arterial occlusive disease (PAOD) is growing worldwide. PAOD corresponds to an impairment of perfusion in the distal portion of some arteries that can generate critical limb ischemia. For some patients, the pathology leads to the necessity of amputation. PAOD may be diagnosed and studied with transcutaneous oxygen (tcpO2) measurements. However, the tcpO2 technique is a contact technique: probes have to be positioned on the limb, which may be impossible in case of ulcers and can lead to infection risks...
July 1, 2017: Computers in Biology and Medicine
Atul Mishra, Narendra Jain, Anand Bhagwat
BACKGROUND: Peripheral arterial occlusive disease (PAOD) may cause disabling claudication or critical limb ischemia. Multidetector computed tomography (CT) technology has evolved to the level of 256-slice CT scanners which has significantly improved the spatial and temporal resolution of the images. This has provided the capability of chasing the contrast bolus at a fast speed enabling angiographic imaging of long segments of the body. These images can be reconstructed in various planes and various modes for detailed analysis of the peripheral vascular diseases which helps in making treatment decision...
July 2017: Vascular and Endovascular Surgery
Răzvan A Ciocan, Sorana D Bolboacă, Şerban Rădulescu, Bogdan Stancu, Andra Ciocan, Claudia D Gherman
AIM: The present study aimed at identifying the pattern of patients with critical limb ischemia (CLI) compared with those with peripheral arterial occlusive disease (PAOD). MATERIALS AND METHODS: A four-year retrospective study was conducted with patients hospitalized in the Second Surgical Clinic at the Emergency County Hospital Cluj-Napoca. The medical charts of patients with PAOD (n=466) and CLI (n=223) were reviewed and data were collected. RESULTS: The study included 689 patients; mean age 67 years for PAOD patients and 65 years for CLI patients...
March 1, 2017: Folia Medica
Sébastien Girold, Jérome Rousseau, Magalie Le Gal, Emmanuel Coudeyre, Jacqueline Le Henaff
BACKGROUND: With Nordic walking, or walking with poles, one can travel a greater distance and at a higher rate than with walking without poles, but whether the activity is beneficial for patients with cardiovascular disease is unknown. OBJECTIVE: This randomized controlled trial was undertaken to determine whether Nordic walking was more effective than walking without poles on walk distance to support rehabilitation training for patients with acute coronary syndrome (ACS) and peripheral arterial occlusive disease (PAOD)...
July 2017: Annals of Physical and Rehabilitation Medicine
Fatih Uzun, Mehmet Erturk, Huseyin Altug Cakmak, Ali Kemal Kalkan, Ibrahim Faruk Akturk, Ahmet Arif Yalcin, Begum Uygur, Umit Bulut, Kursat Oz
INTRODUCTION: Inflammation and increased platelet activation play a crucial role in the initiation and progression of atherosclerosis. Platelet-to-lymphocyte ratio (PLR) has recently been reported as a new independent predictor for major adverse cardiovascular events in cardiovascular diseases. AIM: To investigate the relation between PLR and cardiovascular mortality in patients with intermittent claudication or critical limb ischemia (CLI) or both. MATERIAL AND METHODS: In our retrospective study, 602 consecutive patients who were admitted to a large tertiary hospital with the diagnosis of symptomatic peripheral arterial occlusive disease (PAOD) were included...
2017: Postępy W Kardiologii Interwencyjnej, Advances in Interventional Cardiology
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