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Matthaios G Pitoulias, Lemonia Skoura, Apostolos G Pitoulias, Dimitris Chatzidimitriou, Apostolia Margariti, Minas Arsenakis, Georgios A Pitoulias
Visfatin is an adipokine molecule acting as an essential coenzyme in multiple cellular redox reactions. The increased serum levels of Visfatin have been correlated with metabolic syndrome and endothelial homeostasis. In this study we investigate the possible relationship of Visfatin serum levels with the severity and location of atherosclerotic peripheral arterial occlusive disease (PAOD). Study protocol included 45 consecutive PAOD and 20 Control patients with age >55years old. Definition of PAOD was based in Rutherord's classification (RC)...
January 7, 2017: Cytokine
Szu-Chia Chen, Mei-Yueh Lee, Jiun-Chi Huang, I-Ching Kuo, Hsiu-Chin Mai, Po-Lin Kuo, Jer-Ming Chang, Shang-Jyh Hwang, Hung-Chun Chen
Background and Aim: The ankle-brachial index (ABI) is recognized to be a good marker for atherosclerosis, and is useful in the diagnosis of peripheral artery occlusive disease (PAOD) which is prevalent among patients on hemodialysis (HD). Methods: This randomized trial aimed to evaluate the effect of far-infrared radiation (FIR) therapy on ABI in HD patients with PAOD. PAOD was defined as patients with ABI < 0.95. One hundred and eight HD patients were enrolled, including 50 in the control group and 58 in the FIR group...
2016: International Journal of Medical Sciences
Moritz Wildgruber, Teresa Aschenbrenner, Heiko Wendorff, Maria Czubba, Almut Glinzer, Bernhard Haller, Matthias Schiemann, Alexander Zimmermann, Hermann Berger, Hans-Henning Eckstein, Reinhard Meier, Walter A Wohlgemuth, Peter Libby, Alma Zernecke
Monocytes are key players in atherosclerotic. Human monocytes display a considerable heterogeneity and at least three subsets can be distinguished. While the role of monocyte subset heterogeneity has already been well investigated in coronary artery disease (CAD), the knowledge about monocytes and their heterogeneity in peripheral artery occlusive disease (PAOD) still is limited. Therefore, we aimed to investigate monocyte subset heterogeneity in patients with PAOD. Peripheral blood was obtained from 143 patients suffering from PAOD (Rutherford stage I to VI) and three monocyte subsets were identified by flow cytometry: CD14(++)CD16(-) classical monocytes, CD14(+)CD16(++) non-classical monocytes and CD14(++)CD16(+) intermediate monocytes...
December 19, 2016: Scientific Reports
Kang-Yi Liou, Hung-Hsiang Liou, Yu-Wei Fang, Jyh-Gang Leu, Ming-Hsien Tsai
The cardiothoracic ratio (CTR) and peripheral arterial occlusive disease (PAOD) are related to mortality in hemodialysis patients. However, data on the association between PAOD and CTR are limited. In this study, we aim to elucidate this relationship in patients on chronic hemodialysis. Using a retrospective cross-sectional study of 622 Taiwanese patients, we investigated the association of PAOD and CTR. PAOD was significantly associated with CTR in the crude analysis. The odds ratio (OR) for CTR >0.5 was 1...
December 5, 2016: Scientific Reports
Holger Lawall, Peter Huppert, Christine Espinola-Klein, Gerhard Rümenapf
BACKGROUND: In peripheral arterial occlusive disease (PAOD), arterial stenosis or occlusion impairs perfusion in the territory of the distal portion of the aorta and the iliac and leg arteries. In Germany, the prevalence of PAOD rises with age, reaching 20% among persons over age 70. METHODS: This guideline was prepared by a collaboration of 22 medical specialty societies and two patient self-help organizations on the basis of pertinent publications that were retrieved by a systematic search in PubMed for articles that appeared from 2008 to April 2014, with a subsequent update to May 2015...
October 28, 2016: Deutsches Ärzteblatt International
Ewelina Bąk, Czesław Marcisz, Monika Kadłubowska, Anna Michalik, Bożena Krawczyk, Dorota Dobrzyń-Matusiak, Sylwia Krzemińska, Tomasz Fiałkowski, Elżbieta Glądys, Agnieszka Drosdzol-Cop
Peripheral arterial disease (PAD) belongs to the commonly-occurring pathologies associated with elderly age. A simple tool for defining the severity of PAD is the ankle-brachial index (ABI). The purpose of this research was to determine independent factors of changes of ABI in elderly patients with occlusive PAD disease (PAOD) with and without diabetes. The research was carried out on 49 elderly patients with PAOD, including 29 patients with type 2 diabetes, and 20 patients without diabetes. The concentration of interleukin-6 (IL-6), E-selectin, fibrinogen, and C-reactive protein (CRP) in the blood serum was marked...
November 8, 2016: International Journal of Environmental Research and Public Health
Malcolm Koo, Jin-Cherng Chen, Juen-Haur Hwang
BACKGROUND: Cochleovestibular symptoms, such as vertigo, tinnitus, and sudden deafness, are common manifestations of microvascular diseases. However, it is unclear whether these symptoms occurred preceding the diagnosis of peripheral artery occlusive disease (PAOD). Therefore, the aim of this case-control study was to investigate the risk of PAOD among patients with vertigo, tinnitus, and sudden deafness using a nationwide, population-based health claim database in Taiwan. METHODS: We identified 5,340 adult patients with PAOD diagnosed between January 1, 2006 and December 31, 2010 and 16,020 controls, frequency matched on age interval, sex, and year of index date, from the Taiwan National Health Insurance Research Database...
2016: PloS One
Dimitrios Tsikas, Sabine Rothmann, Jessica Y Schneider, Frank-Mathias Gutzki, Bibiana Beckmann, Jürgen C Frölich
Here, we report the simultaneous derivatization and quantification of malondialdehyde (MDA) and 4-hydroxy-2-nonenal (HNE) in human plasma by GC-MS/MS using [1,3-(2)H2]-MDA (d2-MDA) and [9,9,9-(2)H3]-HNE (d3-HNE) as the internal standards, respectively. MDA, d2-MDA, HNE and d3-HNE were converted to their pentafluorobenzyl oximes (PFBOX) by pentafluorobenzyl hydroxylamine. Subsequently, the hydroxyl groups of the PFBOX of HNE and d3-HNE were trimethylsilylated with of N,O-bis(trimethylsilyl)trifluoroacetamide/1% trimethylchlorosilane...
August 13, 2016: Analytical Biochemistry
P Maga, M Sanak, J Jawien, B Rewerska, M Maga, A Wachsmann, M Koziej, I Gregorczyk-Maga, R Nizankowski
The aim of our study was to determine if the generation of thromboxane is altered in patients with peripheral arterial occlusive disease following percutaneous transluminal angioplasty (PTA) during a one year follow-up period. In this study, 175 patients diagnosed with peripheral arterial occlusive disease (PAOD) and demonstrating short-distance claudication or ischemic rest pain, requiring PTA in either the iliac, femoral, or popliteal arteries, were enrolled. The excretion of 11-dehydro thromboxane B2 (TXB2) was measured in urine samples by high-performance liquid chromatography-mass spectrometry and recalculated based on the creatinine concentration...
June 2016: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
Seung Hyun Lee, Kwan Wook Kim, Hyun-Chel Joo, Kyung-Jong Yoo, Young-Nam Youn
BACKGROUND: To determine the predictors of aggravated left ventricular diastolic dysfunction (LVDD) in patients undergoing off-pump coronary artery bypass grafting (OPCAB) and to compare late outcomes according to the aggravated LVDD. METHODS AND RESULTS: OPCAB was performed in 1,101 patients (2001-2013). LVDD was classified as normal, mild, moderate or severe. Patients were divided into 2 groups: non-aggravated LVDD (group I) and aggravated LVDD (group II)...
August 25, 2016: Circulation Journal: Official Journal of the Japanese Circulation Society
G Mosti, A Cavezzi, G Massimetti, H Partsch
OBJECTIVE/BACKGROUND: Peripheral arterial occlusive disease (PAOD) is reported in about 15-20% of patients with venous leg ulcers (VLU). In such cases arterial recanalization is often recommended, and compression therapy is considered a contraindication when the ankle brachial pressure index (ABPI) is < 0.8. The aim of this study was to compare the outcome of patients with recalcitrant VLU, both without any arterial impairment ("pure venous recalcitrant leg ulcer" [pvRLU]) and with associated PAOD ("mixed arterial and venous recalcitrant leg ulcer" [mavRLU]), by treating only the venous disease...
September 2016: European Journal of Vascular and Endovascular Surgery
Wei-Syun Hu, Cheng-Li Lin, Chih-Yang Huang, Shih-Sheng Chang, Kuan-Cheng Chang
PURPOSE: We conducted this study to evaluate the risk of peripheral artery occlusive disease (PAOD) among patients with cataracts. METHODS: We analyzed the data from Taiwan National Health Insurance Research Database. Study participants were classified into the cataract group and the non-cataract group between 2000 and 2010. All patients were observed from the index year until PAOD diagnosis, loss to follow up, or the end of 2011. Both study groups were 1:1 matching based upon a propensity score...
October 1, 2016: International Journal of Cardiology
G Hackl, P Jud, A Avian, T Gary, H Deutschmann, G Seinost, M Brodmann, F Hafner
OBJECTIVE: The COPART risk score consists of six variables to assess the prognosis of PAOD patients. The flow mediated dilation (FMD) quantifies endothelial function. The aim of this study was to evaluate the mortality prediction of these two variables in a long-term observation of claudicants. METHODS: 184 consecutive claudicants were included in a prospective observational study over a median observation period of 7.9 (IQR 7.2-8.7) years. The endothelial function was assessed on the day of study inclusion using brachial FMD...
August 2016: European Journal of Vascular and Endovascular Surgery
Fenling Fan, Lu Fang, Xiao-Lei Moore, Xuegang Xie, Xiao-Jun Du, David A White, Jessica O'Brien, Helen Thomson, Jun Wang, Hans G Schneider, Andris Ellims, Thomas W Barber, Anthony M Dart
BACKGROUND: Macrophage migration inhibitory factor (MIF) is a key regulator of inflammatory responses, including in the heart. Plasma MIF is elevated early in the course of acute myocardial infarction. In this study, we hypothesized that plasma MIF may also be increased in acute myocardial ischemia. METHODS AND RESULTS: Patients undergoing cardiac stress test (stress nuclear myocardial perfusion scan or stress echocardiography) were recruited. Twenty-two patients had a stress test indicative of myocardial ischemia and were compared with 62 patients who had a negative stress test...
July 2016: Journal of the American Heart Association
Peter Rief, Martin Pichler, Reinhard Raggam, Franz Hafner, Armin Gerger, Philipp Eller, Marianne Brodmann, Thomas Gary
The aspartat aminotransferase (AST)/alanin aminotransferase (ALT) (De-Ritis) ratio (AAR) is an easily applicable blood test. An elevated AAR on the one hand has been associated with an increase in nonalcoholic fatty liver disease (NAFLD). NAFLD on the other hand is associated with an increase in cardiovascular disease, all-cause mortality, and diabetes. As the AAR is also elevated in case of muscular damage, we investigated AAR and its association with critical limb ischemia (CLI) in peripheral arterial occlusive disease (PAOD) patients...
June 2016: Medicine (Baltimore)
Ann N Hoffman, Pooja R Paode, Hazel G May, J Bryce Ortiz, Salma Kemmou, Jonathan Lifshitz, Cheryl D Conrad, Theresa Currier Thomas
In the pathophysiology of traumatic brain injury (TBI), the amygdala remains understudied, despite involvement in processing emotional and stressful stimuli associated with anxiety disorders, such as post-traumatic stress disorder (PTSD). Because the basolateral amygdala (BLA) integrates inputs from sensory and other limbic structures coordinating emotional learning and memory, injury-induced changes in circuitry may contribute to psychiatric sequelae of TBI. This study quantified temporal changes in dendritic complexity of BLA neurons after experimental diffuse TBI, modeled by midline fluid percussion injury...
January 1, 2017: Journal of Neurotrauma
G Tournaire, F Despas, F Huguet, J L Montastruc, E Bondon-Guitton
WHAT IS KNOWN AND OBJECTIVE: Peripheral vascular adverse events have been reported with ponatinib treatment in chronic myeloid leukaemia (CML) after failure of dasatinib or nilotinib. We here report peripheral arterial occlusive disease (PAOD) in a patient who had previously received only imatinib as tyrosine kinase inhibitor. CASE DESCRIPTION: The patient was a 70-year-old man with no history of cardiovascular disease. He developed arterial hypertension 5 months after the initiation of ponatinib and PAOD 41 months later...
June 2016: Journal of Clinical Pharmacy and Therapeutics
Chun-Hsiang Chiu, Cheng-Li Lin, Feng-You Lee, Ying-Chuan Wang, Chia-Hung Kao
Data on the association between peripheral artery occlusive disease (PAOD) and leptospirosis are limited. We conducted a retrospective cohort study for determining whether leptospirosis is one of the possible risk factors for PAOD. Patients diagnosed with leptospirosis by using 2000 to 2010 data from the Taiwan National Health Insurance Research Database. Patients with leptospirosis without a history of PAOD were selected. For each leptospirosis patient, 4 controls without a history of leptospirosis and PAOD were randomly selected and frequency-matched for sex, age, the year of the index date, and comorbidity diseases...
March 2016: Medicine (Baltimore)
Veronika Sanin, Vanessa Pfetsch, Wolfgang Koenig
Cardiovascular disease and cancer are the leading causes of morbidity and mortality worldwide. Low-dose ASA has been shown to effectively prevent about one fifth of atherothrombotic vascular complications in patients with previous myocardial infarction, peripheral arterial occlusive disease (PAOD), or stroke 2. In secondary prevention, the benefits of antiplatelet therapy substantially exceed its risk 2. By contrast, recommendations for the use of ASA in primary prevention are still a matter of controversy...
March 2016: Deutsche Medizinische Wochenschrift
E Bondon-Guitton, S Combret, M C Pérault-Pochat, M Stève-Dumont, H Bagheri, F Huguet, F Despas, A Pathak, J L Montastruc
BACKGROUND: Over the past few years, data have suggested that severe peripheral arterial occlusive disease (PAOD) is associated with nilotinib exposure. However, the characteristics of this adverse drug reaction are poorly described since its frequency is low. As far as we know, no study using a spontaneous adverse drug reactions reporting system was performed to describe the characteristics of cases of PAOD related to nilotinib. OBJECTIVE: We performed a study to describe the cardiovascular risk profile of cases of PAOD in patients treated with nilotinib spontaneously reported to the French Pharmacovigilance Database (FPVD)...
August 2016: Targeted Oncology
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