Read by QxMD icon Read


Fernando Kemta Lekpa, Xavier Chevalier
Relapsing polychondritis is a severe systemic immune-mediated disease characterized by an episodic and progressive inflammatory condition with progressive destruction of cartilaginous structures. This disease has for nearly a century kept secrets not yet explained. The real incidence and prevalence of this rare disease are unknown. The multiple clinical presentations and episodic nature of relapsing polychondritis cause a significant diagnosis delay. No guidelines for the management of patients with relapsing polychondritis have been validated to date...
2018: Open Access Rheumatology: Research and Reviews
Félicite Kamdem, Fernando Kemta Lekpa, Marie Solange Doualla, Yvette Ngo Nouga, Olivier Donfack Sontsa, Elvis Temfack, Samuel Kingue
Chronic kidney disease (CKD) has emerged as a worldwide problem and is a major cause for comorbidity in hypertensive patients. In an attempt to enhance awareness and to help in establishing preventive measures and care, it is necessary to describe CKD among newly diagnosed and untreated hypertensive patients. We conducted a cross-sectional study to describe the characteristics of CKD among newly diagnosed, treatment naïve, hypertensive patients in four health-care centers in the city of Douala, Cameroon. Sociodemographic and biological data were collected and serum creatinine was measured by enzymatic - colorimetric methods...
September 2017: Saudi Journal of Kidney Diseases and Transplantation
Félicité Kamdem, Daniel Lemogoum, Marie-Solange Doualla, Fernando Kemta Lepka, Elvis Temfack, Yvette Ngo Nouga, Caroline Kenmegne, Henry Luma, Michel P Hermans
The authors assessed the frequency of glucose homeostasis abnormalities among 839 Cameroonians with newly diagnosed hypertension (mean age: 50.8±11 years; 49.9% female) in a cross-sectional survey conducted at the Douala General Hospital, Douala, Cameroon. In all participants, blood pressure, fasting plasma glucose (FPG), and lipids were recorded. Impaired fasting glycemia was described as an FPG level between 100 and 125 mg/dL and provisional diabetes as an FPG level ≥126 mg/dL. The FPG was 101±30 mg/dL...
January 2, 2017: Journal of Clinical Hypertension
Henry Namme Luma, Servais Albert Fiacre Bagnaka Eloumou, Domin Sone Majunda Ekaney, Fernando Kemta Lekpa, Olivier Donfack-Sontsa, Bertrand Hugo Mbatchou Ngahane, Yacouba Njankouo Mapoure
BACKGROUND: Liver disease related to Hepatitis B (HBV) and C (HCV) infection has become a major cause of morbidity and mortality in HIV/AIDS patients. Data on the prevalence of HBV and HCV in Cameroon remains inconclusive. OBJECTIVE: We aimed to determine the sero-prevalence and correlates of Hepatitis markers in HIV/AIDS patients in two Regional Hospitals. METHODS: A cross-sectional study carried out from December 2014 to March 2015. HIV/AIDS patients aged 21 were included and above, receiving care at HIV treatment centres...
2016: Open AIDS Journal
Babatunde Olanrewaju Motayo, Bernard Aneibe Onoja, Adedayo Omotayo Faneye, Johnson Adekunle Adeniji
BACKGROUND: West Nile virus (WNV) infection, is an arbovirus infection with high morbidity and mortality, the vector responsible for both human and animal transmission is Culex pipens complex. OBJECTIVE: To determine the species distribution and seasonal abundance of Culex pipens and Culex quinquefasciatus mosquitoes in Abeokuta, Nigeria. METHODS: Mosquitoes belonging to the Culex pipens complex were captured in three different locations located within Abeokuta Metropolis between March 2012 and January 2013...
March 2016: African Health Sciences
Félicité Kamdem, Marie-Solange Doualla, Fernando Kemta Lekpa, Elvis Temfack, Yvette Ngo Nouga, Olivier Sontsa Donfack, Anastase Dzudie, Samuel Kingue
BACKGROUND: Few studies have evaluated the link between hyperuricaemia and cardiovascular disease in sub-Saharan Africa. AIMS: To assess the prevalence of and factors associated with hyperuricaemia among newly diagnosed treatment-naïve hypertensive patients in sub-Saharan Africa. METHODS: We performed a community-based cross-sectional study from January to December 2012 in Douala, Cameroon (Central Africa). We enrolled newly diagnosed treatment-naïve hypertensive patients, and excluded those with gout or a history of gout...
October 2016: Archives of Cardiovascular Diseases
Henry Namme Luma, Servais Albert Fiacre Bagnaka Eloumou, Ellis Atemlefeh Fualefeh-Morfaw, Agnes Malongue, Elvis Temfack, Fernando Kemta Lekpa, Olivier Donfack-Sontsa, Lucy Ndip, Ivo Che Ditah
While gastrointestinal disease is common among HIV infected individuals, the prevalence and distribution of ano-rectal pathology has not been well studied in our setting. The objective of this study therefore was to determine the prevalence and determinants of ano-rectal pathology in HIV infected patients attending the Douala General Hospital HIV treatment centre. A hospital-based cross-sectional study was undertaken. We collected socio-demographic, clinical and laboratory data using a structured questionnaire and patients' files...
May 12, 2016: International Journal of STD & AIDS
Fernando Kemta Lekpa, Souhaïbou Ndongo, Seynabou Fall, Abdoulaye Pouye, Mamadou Mourtalla Ka, Thérèse Moreira-Diop
No abstract text is available yet for this article.
2014: Pan African Medical Journal
Marie Doualla Bija, Henry Namme Luma, Elvis Temfack, Eunice Tafam Gueleko, Fernando Kemta, Madeleine Ngandeu
Osteoarthritis (OA), the most prevalent joint disease in adults, ranks among the top 5 causes of disability. The burden of OA is expected to be greater in developing countries, where life expectancy is increasing and access to joint replacement therapy is not readily available. Risk factors associated with knee OA in Africa may differ from those identified in other parts of the world. This study aimed to establish the prevalence, clinical presentation, and associated factors of knee OA in two large referral centers in Cameroon...
November 2015: Clinical Rheumatology
Fernando Kemta Lekpa, Souhaïbou Ndongo, Joëlle Tiendrebeogo, Awa Cheikh Ndao, Abdikarim Daher, Abdoulaye Pouye, Mamadou Mourtalla Ka, Thérèse Moreira Diop
Several studies have suggested that rheumatoid arthritis (RA) is uncommon in rural sub-Saharan Africa. The aim of this study is to determine the potential differences between patients with RA living in rural areas and those living in urban areas. We performed a cross-sectional study from June 2006 to May 2009. We included all patients with RA (1987 ACR criteria) seen at the Rheumatology Unit of the Le Dantec Teaching Hospital, Dakar, Senegal. We compared the main socio-demographic and clinical characteristics of patients living in rural areas to those living in urban areas...
November 2012: Clinical Rheumatology
Fernando Kemta Lekpa, Cécile Poulain, Daniel Wendling, Martin Soubrier, Michel De Bandt, Jean Marie Berthelot, Philippe Gaudin, Eric Toussirot, Philippe Goupille, Thao Pham, Jérémie Sellam, Rémy Bruckert, Muriel Paul, Valérie Farrenq, Pascal Claudepierre
INTRODUCTION: The aim of this study was to evaluate, under real-life conditions, the safety and efficacy of tocilizumab in patients having failed anti-TNFα therapy for spondyloarthritis. METHODS: French rheumatologists and internal-medicine practitioners registered on the Club Rhumatismes et Inflammations website were asked to report on patients given tocilizumab (4 or 8 mg/kg) to treat active disease meeting Assessment of SpondyloArthritis International Society (ASAS) criteria for axial or peripheral spondyloarthritis, after anti-TNFα treatment failure...
March 9, 2012: Arthritis Research & Therapy
F Canouï-Poitrine, F Kemta Lekpa, V Farrenq, V Boissinot, C Hacquard-Bouder, D Comet, S Bastuji-Garin, E Thibout, P Claudepierre
OBJECTIVE: To accurately estimate the prevalence of and the factors associated with uveitis in spondylarthritis (SpA) patients in France. METHODS: In an observational survey of SpA patients (diagnosis confirmed by the European Spondylarthropathy Study Group and/or Amor's criteria) consulting their rheumatologist for routine followup, we collected information regarding present/past history of uveitis, as well as detailed characteristics of the disease. Factors independently associated with uveitis were determined...
June 2012: Arthritis Care & Research
Fernando Kemta Lekpa, Virginia B Kraus, Xavier Chevalier
BACKGROUND: There is no standardized therapeutic protocol for relapsing polychondritis (RP). Emergence of biologics holds much hope in the management of this connective tissue disease. OBJECTIVES: To evaluate the efficacy and safety of biologics in patients with active RP. METHODS: A systematic review of the literature using PubMed was performed through December 2010. MeSH terms and keywords were used relating to RP and biologics. All papers reporting the efficacy and/or safety of biologics in RP were selected...
April 2012: Seminars in Arthritis and Rheumatism
Fernando Kemta Lekpa, Valérie Farrenq, Florence Canouï-Poitrine, Muriel Paul, Xavier Chevalier, Rémy Bruckert, Sylvie Bastuji-Garin, Pascal Claudepierre
OBJECTIVE: To assess the efficacy of abatacept in patients with axial spondyloarthropathies who had failed TNFα antagonist therapy. METHODS: Consecutive patients fulfilling criteria for active axial spondyloarthropathy, despite at least two previous TNFα antagonists, were treated with abatacept (10mg/kg) given on days 1, 15, and 29, then every 28 days until week 24. Clinical and laboratory outcome criteria were assessed monthly for 6 months. RESULTS: Seven patients were treated and followed, all women (median age, 39 years; median disease duration, 12 years), five with ankylosing spondylitis and two with undifferentiated spondyloarthropathy...
January 2012: Joint, Bone, Spine: Revue du Rhumatisme
F Kemta Lekpa, G Lenczner, V Farrenq, P Claudepierre
It is becoming increasingly desirable to diagnose ankylosing spondyloarthropathy (AS) at its pre-radiographic stage (prior to the presence of sacro-iliitis on radiographs). MRI plays a key role for early diagnosis of AS, as illustrated by recently proposed international diagnostic criteria (ASAS). MRI of the SI joints is most helpful for early diagnosis; sequences using fat suppression and/or Gadolinium administration are necessary for the detection of inflammatory changes. However, the rate of false positive and false negative results of MR imaging of the SI joints, especially early in the course of the disease, is unknown and requires prudent interpretation of imaging findings...
January 2010: Journal de Radiologie
F Kemta Lekpa, K Zahra, C Pautas, S Maury, X Chevalier, P Claudepierre
Concern has arisen regarding a possible increase in the risk of malignant diseases such as lymphoproliferative disorders in a patient taking TNF-alpha antagonists for the treatment of chronic inflammatory diseases. The evidence of a causal link remains unclear. We report a case of 60-year-old male patient who developed acute myeloid leukemia during infliximab therapy for ankylo-sing spondylitis.
November 2009: Clinical and Experimental Rheumatology
Fernando Kemta Lekpa, Valérie Farrenq, Pascal Claudepierre
Spondylarthropathies include the ankylosing spondylitis, psoriatic arthritis, reactive arthritis, arthritis of inflammatory bowel disease (Crohn disease, ulcerative colitis), some juvenile arthritis and undifferenciated spondylarthropathies. These diseases are linked together by a basic elementary lesion, enthesitis, common clinical and radiological features (sacroiliitis, spondylitis, peripheral arthritis, extra-articular manifestations), and association with HLA B27 antigen. Prevalence of spondylarthropathies in France is estimated at 0...
April 20, 2009: La Revue du Praticien
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"