keyword
https://read.qxmd.com/read/38496414/brain-orchestra-under-spontaneous-conditions-identifying-communication-modules-from-the-functional-architecture-of-area-v1
#21
Maria Papadopouli, Ioannis Smyrnakis, Emmanouil Koniotakis, Mario-Alexios Savaglio, Christina Brozi, Eleftheria Psilou, Ganna Palagina, Stelios Manolis Smirnakis
We used two-photon imaging to record from granular and supragranular layers in mouse primary visual cortex (V1) under spontaneous conditions and applied an extension of the spike time tiling coefficient (STTC; introduced by Cutts and Eglen) to map functional connectivity architecture within and across layers. We made several observations: Approximately, 19-34% of neuronal pairs within 300 µ m of each other exhibit statistically significant functional connections, compared to 10% at distances of 1mm or more...
March 4, 2024: bioRxiv
https://read.qxmd.com/read/38496348/de-novo-formation-of-remote-dural-arteriovenous-fistula-following-treated-cavernous-sinus-dural-arteriovenous-fistula
#22
JOURNAL ARTICLE
Prasert Iampreechakul, Korrapakc Wangtanaphat, Songpol Chuntaroj, Chonlada Angsusing, Yodkhwan Wattanasen, Sunisa Hangsapruek, Punjama Lertbusayanukul, Somkiet Siriwimonmas
BACKGROUND: The development of new dural arteriovenous fistulas (DAVFs) at another location following endovascular treatment of cavernous sinus DAVFs (CSDAVFs) are extremely rare. Our aim is to review cases of de Novo DAVFs that occurred after treatment of CSDAVFs at our institution and those reported in the literature. METHODS: We reviewed all cases of CSDAVFs evaluated by 2 experienced neuroradiologists. A literature search was performed using the PRISMA (preferred reporting items for systematic reviews and meta-analyses) guidelines focusing on De Novo DAVFs following the endovascular treatment of cerebrovascular malformations...
April 2024: World neurosurgery: X
https://read.qxmd.com/read/38496185/the-protective-effect-of-abortion-on-preeclampsia-an-analysis-of-current-research
#23
REVIEW
Sarah J Norman, Gena Fontus, Chancée Forestier, Tasneem Hiba, Stephanie Colon Pagan, Michael Osondu, Volha Shylovich
A review of the current literature on preeclampsia (PE) confirms that this pregnancy complication remains a common cause of maternal mortality. Within the last several decades, obstetric and gynecological researchers worldwide have indicated an association between prior abortions and the development of PE. Different studies have debated whether abortion is a protective or risk factor for PE. However, the most current literature demonstrates a stronger likelihood that a positive history of abortions will offer a protective effect against PE...
February 2024: Curēus
https://read.qxmd.com/read/38496151/elastic-banding-compression-as-a-novel-treatment-to-maintain-hemodynamics-in-a-patient-with-klippel-trenaunay-syndrome
#24
Satoshi Kamiya, Takahiro Kato, Masakazu Yasuuji, Hiroyuki Tanaka, Yasuo M Tsutsumi
Klippel-Trenaunay syndrome (KTS) is also associated with venous thrombosis originating from varicose veins in the lower extremities, pulmonary embolism, and pulmonary hypertension. This study describes the anesthetic management of laparoscopic cholecystectomy in a 54-year-old male KTS patient with orthostatic hypotension due to massive varicose veins in the lower extremities and pulmonary thromboembolism. Compressing the varicosities with an elastic bandage can maintain stable circulatory dynamics even under general anesthesia management to prevent position and insufflation-induced changes that can occur spontaneously...
February 2024: Curēus
https://read.qxmd.com/read/38496126/spontaneous-pregnancy-after-the-removal-of-long-term-retained-laminaria
#25
Mika Miyamori, Akihiro Hamuro, Kohei Kitada, Takuya Misugi, Daisuke Tachibana
We report the case of a woman with laminaria retention up to six years, followed by spontaneous pregnancy after the removal by hysteroscope of the intrauterine retained laminaria. A 26-year-old woman (G1P0) visited our hospital with complaints of prolonged menstrual bleeding, dyspareunia, and infertility. She had a history of dilatation and evacuation (D&E) at nine weeks of gestation six years earlier. A transvaginal ultrasound showed an artifact, and hysteroscopy revealed a long foreign body, which was suspected to be a laminaria retained after the prior abortion...
February 2024: Curēus
https://read.qxmd.com/read/38496041/in-situ-engineering-of-conducting-polymer-nanocomposites-at-liquid-liquid-interfaces-a-perspective-on-fundamentals-to-technological-significance
#26
REVIEW
Mini Mol Menamparambath
The conducting polymers have continuously been hybridized with their counterparts to overcome the intrinsic functional limitations compared to the metallic or inorganic analogs. Remarkably, the liquid/liquid interface-assisted methods represent an efficient and facile route for developing fully tunable metamaterials for various applications. The spontaneous adsorption of nanostructures at a quasi-two-dimensional interface is energetically favorable due to the reduction in interfacial tension, interfacial area, and interfacial energy (Helmholtz free energy)...
March 13, 2024: ACS Mater Au
https://read.qxmd.com/read/38495997/synergetic-and-advanced-isotherm-investigation-for-the-enhancement-influence-of-zeolitization-and-%C3%AE-cyclodextrin-hybridization-on-the-retention-efficiency-of-u-vi-ions-by-diatomite
#27
JOURNAL ARTICLE
Ashour M Ahmed, Islam Saad, M Abdel Rafea, Mostafa R Abukhadra
In synergetic investigations, the adsorption effectiveness of diatomite-based zeolitic structure (ZD) as well as its β-cyclodextrin (CD) hybrids (CD/ZD) towards uranium ions (U(vi)) was evaluated to examine the influence of the transformation procedures. The retention behaviors and mechanistic processes have been demonstrated through analyzing the steric and energetic factors employing the modern equilibrium approach (a monolayer model with a single energy level). After the saturation phase, the uptake characteristics of U(vi) were dramatically improved to 297...
March 14, 2024: RSC Advances
https://read.qxmd.com/read/38495657/spectrum-of-ischemic-heart-disease-throughout-a-woman-s-life-cycle
#28
REVIEW
Smitha Narayana Gowda, Sai Sita Garapati, Karla Kurrelmeyer
Ischemic heart disease (IHD) is the leading cause of morbidity and mortality in both genders; however, young women fare the worst, likely reflecting the more complex spectrum of IHD in women when compared to men. Substantial sex-based differences exist in the underlying risk factors, risk enhancers, presentation, diagnosis, and pathophysiology of IHD that are mainly attributed to the influence of female sex hormones. This article reviews the spectrum of IHD including obstructive epicardial coronary artery disease (CAD), myocardial infarction with no obstructive coronary artery disease, ischemia with no obstructive coronary artery disease, spontaneous coronary artery dissection, coronary microvascular dysfunction, vasospastic angina, and coronary thrombosis/embolism that occur in women throughout various stages of their life cycle...
2024: Methodist DeBakey Cardiovascular Journal
https://read.qxmd.com/read/38495551/human-mutations-in-slitrk3-implicated-in-gabaergic-synapse-development-in-mice
#29
JOURNAL ARTICLE
Stephanie Efthymiou, Wenyan Han, Muhammad Ilyas, Jun Li, Yichao Yu, Marcello Scala, Nancy T Malintan, Muhammad Ilyas, Nikoleta Vavouraki, Kshitij Mankad, Reza Maroofian, Clarissa Rocca, Vincenzo Salpietro, Shenela Lakhani, Eric J Mallack, Timothy Blake Palculict, Hong Li, Guojun Zhang, Faisal Zafar, Nuzhat Rana, Noriko Takashima, Hayato Matsunaga, Claudia Manzoni, Pasquale Striano, Mark F Lythgoe, Jun Aruga, Wei Lu, Henry Houlden
This study reports on biallelic homozygous and monoallelic de novo variants in SLITRK3 in three unrelated families presenting with epileptic encephalopathy associated with a broad neurological involvement characterized by microcephaly, intellectual disability, seizures, and global developmental delay. SLITRK3 encodes for a transmembrane protein that is involved in controlling neurite outgrowth and inhibitory synapse development and that has an important role in brain function and neurological diseases. Using primary cultures of hippocampal neurons carrying patients' SLITRK3 variants and in combination with electrophysiology, we demonstrate that recessive variants are loss-of-function alleles...
2024: Frontiers in Molecular Neuroscience
https://read.qxmd.com/read/38495426/chronic-alcohol-induced-long-lasting-working-memory-deficits-are-associated-with-altered-histone-h3k9-dimethylation-in-the-prefrontal-cortex
#30
JOURNAL ARTICLE
Mael De Clerck, Martin Manguin, Nadia Henkous, Marion N d'Almeida, Daniel Beracochea, Nicole Mons
INTRODUCTION: Epigenetic modifications have emerged as key contributors to the enduring behavioral, molecular and epigenetic neuroadaptations during withdrawal from chronic alcohol exposure. The present study investigated the long-term consequences of chronic alcohol exposure on spatial working memory (WM) and associated changes of transcriptionally repressive histone H3 lysine 9 dimethylation (H3K9me2 ) in the prefrontal cortex (PFC). METHODS: Male C57BL/6 mice were allowed free access to either 12% (v/v) ethanol for 5 months followed by a 3-week abstinence period or water...
2024: Frontiers in Behavioral Neuroscience
https://read.qxmd.com/read/38495223/temporal-trends-in-the-incidence-and-outcomes-of-shock-refractory-ventricular-fibrillation-out-of-hospital-cardiac-arrest
#31
JOURNAL ARTICLE
Abdulrahman Alhenaki, Zainab Alqudah, Brett Williams, Emily Nehme, Ziad Nehme
AIM: We aimed to describe trends in the incidence and outcomes of refractory ventricular fibrillation (RVF) compared to non-refractory ventricular fibrillation (non-RVF) in out-of-hospital cardiac arrest (OHCA). METHODS: Between 2010 and 2019, we included all OHCA cases involving adults ≥ 16 years old with an initial shockable rhythm and who received an attempted resuscitation by Emergency Medical Services (EMS) or a bystander shock prior to EMS arrival in Victoria, Australia...
June 2024: Resuscitation plus
https://read.qxmd.com/read/38494890/dynamic-nonreversibility-view-of-intrinsic-brain-organization-and-brain-dynamic-analysis-of-repetitive-transcranial-magnitude-stimulation
#32
JOURNAL ARTICLE
Liming Fan, Youjun Li, Xingjian Zhao, Zi-Gang Huang, Tian Liu, Jue Wang
Intrinsic neural activities are characterized as endless spontaneous fluctuation over multiple time scales. However, how the intrinsic brain organization changes over time under local perturbation remains an open question. By means of statistical physics, we proposed an approach to capture whole-brain dynamics based on estimating time-varying nonreversibility and k-means clustering of dynamic varying nonreversibility patterns. We first used synthetic fMRI to investigate the effects of window parameters on the temporal variability of varying nonreversibility...
March 1, 2024: Cerebral Cortex
https://read.qxmd.com/read/38494736/modeled-hepatic-plasma-exposures-of-fluvastatin-prescribed-alone-in-subjects-with-impaired-cytochrome-p450-2c9-3-as-one-of-possible-determinant-factors-likely-associated-with-hepatic-toxicity-reported-in-a-japanese-adverse-event-database
#33
JOURNAL ARTICLE
Koichiro Adachi, Katsuhiro Ohyama, Yoichi Tanaka, Yoshiro Saito, Makiko Shimizu, Hiroshi Yamazaki
Fluvastatin is a 3-hydroxy-3-methylglutaryl CoA reductase inhibitor that competitively inhibits human cytochrome P450 (P450) 2C9 in vitro. Drug interactions between a variety of P450 2C9 substrates/inhibitors and fluvastatin can increase the incidence of fluvastatin-related hepatic or skeletal muscle toxicity in vivo. In this survey, the prescribed dosage of fluvastatin was reduced or discontinued in 133 of 164 patients receiving fluvastatin alone, as recorded in the Japanese Adverse Drug Event Report database of spontaneously reported events...
2024: Biological & Pharmaceutical Bulletin
https://read.qxmd.com/read/38494136/two-multimodal-neuroimaging-subtypes-of-obsessive-compulsive-disorder-disclosed-by-semi-supervised-machine-learning
#34
JOURNAL ARTICLE
Zhipeng Ding, Tinghuizi Shang, Zhenning Ding, Xu Yang, Jiale Qi, Xiaoqing Qin, Yunhui Chen, Dan Lv, Tong Li, Jidong Ma, Chuang Zhan, Jian Xiao, Zhenghai Sun, Na Wang, Zengyan Yu, Chengchong Li, Ping Li
BACKGROUND: Obsessive-compulsive disorder (OCD) is a highly heterogeneous mental condition with a diverse symptom. Existing studies classified OCD on the basis of conventional phenomenology-based taxonomy ignoring the fact that the same subtype identified in accordance with clinical symptom may have different mechanisms and treatment responses. METHODS: This research involved 50 medicine-free patients with OCD and 50 matched healthy controls (HCs). All the participants were subjected to structural and functional magnetic resonance imaging (MRI)...
March 15, 2024: Journal of Affective Disorders
https://read.qxmd.com/read/38494041/impaired-culprit-vessel-flow-affects-percutaneous-coronary-intervention-outcomes-in-spontaneous-coronary-artery-dissections
#35
JOURNAL ARTICLE
Stefano Benenati, Federico Giacobbe, Fernando Macaya, Giuseppe Patti, Giuseppe Musumeci, Nieves Gonzalo, Javier Escaned, Ferdinando Varbella, Enrico Cerrato, Italo Porto
No abstract text is available yet for this article.
March 15, 2024: American Journal of Cardiology
https://read.qxmd.com/read/38493765/rationale-and-design-of-the-statins-use-in-intracerebral-hemorrhage-patients-saturn-trial
#36
JOURNAL ARTICLE
Sarah Marchina, Sharon D Yeatts, Lydia D Foster, Scott Janis, Ashkan Shoamanesh, Pooja Khatri, Kimberlee Bernstein, Aaron Perlmutter, Catherine Stever, Elizabeth C Heistand, Joseph P Broderick, Steven M Greenberg, Enrique C Leira, Jonathan Rosand, Vasileios-Arsenios Lioutas, Rustam Al Shahi Salman, David Tirschwell, Joan Marti-Fabregas, Magdy Selim
INTRODUCTION: The benefits and risks of HMG-CoA reductase inhibitor (statin) drugs in survivors of intracerebral hemorrhage (ICH) are unclear. Observational studies suggest an association between statin use and increased risk of lobar ICH, particularly in patients with apolipoprotein-E (APOE) ε2 and ε4 genotypes. There are no randomized controlled trials (RCTs) addressing the effects of statins after ICH leading to uncertainty as to whether statins should be used in patients with lobar ICH who are at high risk for ICH recurrence...
March 16, 2024: Cerebrovascular Diseases
https://read.qxmd.com/read/38493469/spontaneous-reperfusion-in-stemi-its-mechanisms-and-possible-modulation
#37
JOURNAL ARTICLE
Joshua H Leader, Rahim Kanji, Diana A Gorog
Patients with transient ST-segment elevation myocardial infarction or spontaneous reperfusion, which occurs in approximately 20% of patients with ST-segment elevation myocardial infarction (STEMI), have smaller infarcts and more favourable clinical outcomes than patients without spontaneous reperfusion. Understanding the mechanisms underlying spontaneous reperfusion is therefore important, since this may identify possible novel therapeutic targets to improve outcomes in patients with STEMI. In this review, we discuss some of the possible determinants of spontaneous reperfusion including pro-thrombotic profile, endogenous fibrinolytic status, lipoprotein(a) (Lp(a)), inflammatory markers and neutrophil extracellular traps (NETs)...
March 17, 2024: Kardiologia Polska
https://read.qxmd.com/read/38493466/spontaneous-closure-of-iatrogenic-epicardial-coronary-pseudoaneurysm-with-fistula-to-right-ventricle-following-post-stenting-perforation
#38
JOURNAL ARTICLE
Wojciech Jan Skorupski, Marta Kałużna-Oleksy, Grzegorz Krupka, Włodzimierz Skorupski, Marek Grygier, Maciej Lesiak
No abstract text is available yet for this article.
March 17, 2024: Kardiologia Polska
https://read.qxmd.com/read/38493197/spymask-enables-combinatorial-assembly-of-bispecific-binders
#39
JOURNAL ARTICLE
Claudia L Driscoll, Anthony H Keeble, Mark R Howarth
Bispecific antibodies are a successful and expanding therapeutic class. Standard approaches to generate bispecifics are complicated by the need for disulfide reduction/oxidation or specialized formats. Here we present SpyMask, a modular approach to bispecifics using SpyTag/SpyCatcher spontaneous amidation. Two SpyTag-fused antigen-binding modules can be precisely conjugated onto DoubleCatcher, a tandem SpyCatcher where the second SpyCatcher is protease-activatable. We engineer a panel of structurally-distinct DoubleCatchers, from which binders project in different directions...
March 16, 2024: Nature Communications
https://read.qxmd.com/read/38493061/spontaneous-pneumothorax-and-massive-subcutaneous-emphysema-in-a-patient-with-klebsiella-pneumoniae-necrotizing-pneumonia
#40
JOURNAL ARTICLE
Helena Camino Ferró, Sergio Gómez Camino, Enrique Chicote Álvarez
No abstract text is available yet for this article.
March 15, 2024: Medicina intensiva
keyword
keyword
74354
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.