keyword
https://read.qxmd.com/read/38493469/spontaneous-reperfusion-in-stemi-its-mechanisms-and-possible-modulation
#1
JOURNAL ARTICLE
Joshua H Leader, Rahim Kanji, Diana A Gorog
Patients with transient ST-segment elevation myocardial infarction or spontaneous reperfusion, which occurs in approximately 20% of patients with ST-segment elevation myocardial infarction (STEMI), have smaller infarcts and more favourable clinical outcomes than patients without spontaneous reperfusion. Understanding the mechanisms underlying spontaneous reperfusion is therefore important, since this may identify possible novel therapeutic targets to improve outcomes in patients with STEMI. In this review, we discuss some of the possible determinants of spontaneous reperfusion including pro-thrombotic profile, endogenous fibrinolytic status, lipoprotein(a) (Lp(a)), inflammatory markers and neutrophil extracellular traps (NETs)...
March 17, 2024: Kardiologia Polska
https://read.qxmd.com/read/38493466/spontaneous-closure-of-iatrogenic-epicardial-coronary-pseudoaneurysm-with-fistula-to-right-ventricle-following-post-stenting-perforation
#2
JOURNAL ARTICLE
Wojciech Jan Skorupski, Marta Kałużna-Oleksy, Grzegorz Krupka, Włodzimierz Skorupski, Marek Grygier, Maciej Lesiak
No abstract text is available yet for this article.
March 17, 2024: Kardiologia Polska
https://read.qxmd.com/read/38493197/spymask-enables-combinatorial-assembly-of-bispecific-binders
#3
JOURNAL ARTICLE
Claudia L Driscoll, Anthony H Keeble, Mark R Howarth
Bispecific antibodies are a successful and expanding therapeutic class. Standard approaches to generate bispecifics are complicated by the need for disulfide reduction/oxidation or specialized formats. Here we present SpyMask, a modular approach to bispecifics using SpyTag/SpyCatcher spontaneous amidation. Two SpyTag-fused antigen-binding modules can be precisely conjugated onto DoubleCatcher, a tandem SpyCatcher where the second SpyCatcher is protease-activatable. We engineer a panel of structurally-distinct DoubleCatchers, from which binders project in different directions...
March 16, 2024: Nature Communications
https://read.qxmd.com/read/38493061/spontaneous-pneumothorax-and-massive-subcutaneous-emphysema-in-a-patient-with-klebsiella-pneumoniae-necrotizing-pneumonia
#4
JOURNAL ARTICLE
Helena Camino Ferró, Sergio Gómez Camino, Enrique Chicote Álvarez
No abstract text is available yet for this article.
March 15, 2024: Medicina intensiva
https://read.qxmd.com/read/38493060/weaning-from-mechanical-ventilation-speed-it-up-and-make-it-safe
#5
JOURNAL ARTICLE
Patricia Rodriguez, Gonzalo Hernández
No abstract text is available yet for this article.
March 15, 2024: Medicina intensiva
https://read.qxmd.com/read/38492911/aquaporine-4-inhibition-attenuates-pentylentetrazole-induced-behavioral-seizures-and-cognitive-impairments-in-kindled-rats
#6
JOURNAL ARTICLE
Fatemeh Rostami, Ali Jaafari Suha, Mahyar Janahmadi, Narges Hosseinmardi
Epilepsy is a neurological condition distinguished by recurrent and unexpected seizures. Astrocytic channels and transporters are essential for maintaining normal neuronal functionality. The astrocytic water channel aquaporin-4 (AQP4), which plays a pivotal role in regulating water homeostasis, is a potential target for epileptogenesis. In present study, we examined the effect of different doses (10, 50, 100 μM and 5 mM) of AQP4 inhibitor, 2-nicotinamide-1, 3, 4-thiadiazole (TGN-020), during kindling acquisition, on seizure parameters and seizure-induced cognitive impairments...
March 14, 2024: Physiology & Behavior
https://read.qxmd.com/read/38492772/bruton-s-tyrosine-kinase-inhibition-for-the-treatment-of-allergic-disorders
#7
REVIEW
Erica V Lin, Ragha V Suresh, Melanie C Dispenza
IgE signaling through its high-affinity receptor FcεRI is central to the pathogenesis of numerous allergic disorders. Oral inhibitors of Bruton's tyrosine kinase (BTKis), which are currently FDA-approved for the treatment of B cell malignancies, broadly inhibit the FcεRI pathway in human mast cells and basophils and therefore may be effective allergen-independent therapies for a variety of allergic diseases. The application of these drugs to the allergy space was previously limited by the low kinase selectivity and subsequent toxicities of early-generation compounds...
March 14, 2024: Annals of Allergy, Asthma & Immunology
https://read.qxmd.com/read/38492714/systemic-lupus-erythematosus-is-associated-with-an-increased-frequency-of-spontaneous-preterm-births-systematic-review-and-meta-analysis
#8
REVIEW
Carolien N H Abheiden, Birgit S Blomjous, Ciska Slaager, Anadeijda J E M C Landman, Johannes C F Ket, Jane E Salmon, Jill P Buyon, Martijn W Heymans, Johanna I P DE Vries, Irene E M Bultink, Marjon A DE Boer
OBJECTIVE: Preterm birth (PTB) is one of the most frequent complications of pregnancies in women with systemic lupus erythematosus (SLE). The high indicated PTB proportion due to hypertensive disorders of pregnancy and/or fetal growth restriction is well known, and preventive measures as well as screening for early detection are performed. The risk of spontaneous PTB is less well recognized. The purpose of this study is to determine the proportions of spontaneous and indicated PTB in pregnancies of women with SLE DATA SOURCES: A systematic literature search using Pubmed, Embase, Web of Science and Google Scholar was performed in June 2021 STUDY ELIGIBILITY CRITERIA: Studies in pregnant women with SLE reporting spontaneous and indicated PTB rates were selected...
March 14, 2024: American Journal of Obstetrics and Gynecology
https://read.qxmd.com/read/38492681/efficient-removal-of-ciprofloxacin-and-ofloxacin-from-aqueous-solutions-using-a-novel-nano-scale-adsorbent-modeling-optimization-and-characterization
#9
JOURNAL ARTICLE
Omid Farzinmanesh, Mina Hosseini Sabzevari, Mohammad Reza Asghari
In the fascinating realm of water purification, our study unveils the remarkable potential of a cutting-edge nano-scale adsorbent-combining graphene oxide (GO), chitosan (CS), and polydopamine (PDA)-in efficiently remove ciprofloxacin (CPF) and ofloxacin (OFL) from aqueous solutions. Our exploration delves deep into the adsorbent's character, utilizing a range of analytical techniques including SEM, RAMAN, FTIR, TGA, BET, XRD, and Zeta potential analyses provided insights into the adsorbent's properties. Modeling the adsorption process with Response Surface Methodology (RSM), Artificial Neural Network (ANN) and General Regression Neural Network (GRNN) indicated excellent predictions by GRNN, with RMSE = 0...
March 14, 2024: Chemosphere
https://read.qxmd.com/read/38492659/mechanical-and-signaling-responses-of-unloaded-rat-soleus-muscle-to-chronically-elevated-%C3%AE-myosin-activity
#10
JOURNAL ARTICLE
K V Sergeeva, S A Tyganov, K A Zaripova, R O Bokov, L V Nikitina, T S Konstantinova, G R Kalamkarov, B S Shenkman
It has been reported that muscle functional unloading is accompanied by an increase in motoneuronal excitability despite the elimination of afferent input. Thus, we hypothesized that pharmacological potentiation of spontaneous contractile soleus muscle activity during hindlimb unloading could activate anabolic signaling pathways and prevent the loss of muscle mass and strength. To investigate these aspects and underlying molecular mechanisms, we used β-myosin allosteric effector Omecamtiv Mekarbil (OM)...
March 14, 2024: Archives of Biochemistry and Biophysics
https://read.qxmd.com/read/38492555/finger-counting-finger-number-gesturing-and-basic-numerical-skills-a-cross-sectional-study-in-3-to-5-year-olds
#11
JOURNAL ARTICLE
Stephanie Roesch, Korbinian Moeller, Julia Bahnmueller
Recent evidence suggests that using finger-based strategies is beneficial for the acquisition of basic numerical skills. There are basically two finger-based strategies to be distinguished: (a) finger counting (i.e., extending single fingers successively) and (b) finger number gesturing (i.e., extending fingers simultaneously to represent magnitudes). In this study, we investigated both spontaneous and prompted finger counting and finger number gesturing as well as their contribution to basic numerical skills in 3- to 5-year-olds (N = 156)...
March 15, 2024: Journal of Experimental Child Psychology
https://read.qxmd.com/read/38492473/beyond-task-response-pre-stimulus-activity-modulates-contents-of-consciousness
#12
REVIEW
Georg Northoff, Federico Zilio, Jianfeng Zhang
The current discussion on the neural correlates of the contents of consciousness (NCCc) focuses mainly on the post-stimulus period of task-related activity. This neglects the substantial impact of the spontaneous or ongoing activity of the brain as manifest in pre-stimulus activity. Does the interaction of pre- and post-stimulus activity shape the contents of consciousness? Addressing this gap in our knowledge, we review and converge two recent lines of findings, that is, pre-stimulus alpha power and pre- and post-stimulus alpha trial-to-trial variability (TTV)...
March 4, 2024: Physics of Life Reviews
https://read.qxmd.com/read/38492472/hla-g-isoforms-hla-c-allotype-and-their-expressions-differ-between-early-abortus-and-placenta-in-relation-to-spontaneous-abortions
#13
JOURNAL ARTICLE
Mayuri Bora, Sushmita Singha, Taruna Madan, Gitanjali Deka, Sumita Gogoi Hazarika, Shashi Baruah
INTRODUCTION: Spontaneous abortion (SAB) affects approximately 10% of clinically recognized pregnancies. Fetal trophobalst invasion and remodeling of maternal spiral arteries is reported to be dependent on crosstalk between HLA-C/HLA-G expressed on extra villous trophoblast (EVTs)and Killer cell Immunoglobin like receptors (KIRs) of decidual NK (dNK). Immune dysfunction in decidua contributes to early miscarriage. METHODOLOGY: The study used mother neonate paired cord blood and term placenta samples (n = 46), elective abortus (n = 17,gestational age = 10-12 weeks of pregnancy) and SAB abortus (n = 24, gestational age = 12-15 weeks of pregnancy) for HLA-G, KIR2D and HLA-C...
March 11, 2024: Placenta
https://read.qxmd.com/read/38492434/association-of-maternal-blood-high-mobility-group-box-1-levels-and-adverse-pregnancy-outcomes-a-systematic-review-and-meta-analysis
#14
REVIEW
Liping Xue, Ruolin Chen, Ying Liu, Peiguang Niu, Jintuo Zhou, Jinhua Liu, Jinhua Zhang, Huajiao Chen
Conflicting findings have emerged regarding the levels of high mobility group box 1 (HMGB1) in individuals experiencing adverse pregnancy outcomes. Here we conducted a meta-analysis to assess the association between maternal blood HMGB1 levels and adverse pregnancy outcomes. Utilizing databases such as PubMed, Cochrane Central Register of Controlled Trials, Web of Science, Embase and China National Knowledge Infrastructure (CNKI), a systematic literature search was conducted in January 2024. Eligible literature was screened according to inclusion and exclusion criteria...
March 15, 2024: Reproductive Biology
https://read.qxmd.com/read/38492381/seaweed-inspired-underwater-anti-oil-fouling-and-anti-fogging-coating-with-mechanical-durability
#15
JOURNAL ARTICLE
Keda Jiang, Zhihua Yang, Yifan Luo, Xiaohang Xue, Feiran Li, Bharat Bhushan, Yunlu Pan, Yanqiang Huo, Xuezeng Zhao, Libo Li, Jun Wei, Wenxin Cao
Ecofriendly fabrication of anti-oil-fouling materials is of interest. Surfaces with underwater superoleophobicity have been fabricated which exhibit limited mechanical durability and water resistance. In this study, we report on a bioinspired bilayer design of a transparent anti-oil-fouling coating. Seaweed surfaces show anti-oil-fouling in the sea due to its high surface hydration ability. Mussels can adhere tightly onto a surface with good stability in the sea by virtue of its levodopa-containing secretions...
February 29, 2024: Journal of Colloid and Interface Science
https://read.qxmd.com/read/38492366/lancao-decoction-alleviates-cognitive-dysfunction-a-new-therapeutic-drug-and-its-therapeutic-mechanism
#16
JOURNAL ARTICLE
Yan Sun, Hailou Zhang, Ruiyi Liu, Rumin Huang, Ziwei Gao, Liyuan Tian, Yaping Zhu, Yuxin Liu, Chao Lu, Lei Wu
BACKGROUND: Cognitive dysfunction (CD) is a neurodegenerative disease characterized primarily by the decline of learning and memory abilities. The physiological and pathological mechanisms of CD are very complex, which is mainly related to normal function of the hippocampus. Lancao decoction (LC) is a Chinese medicine formula, which has been used to treat neurodegenerative disorders. However, the potential of LC for the treatment of CD, as well as its underlying mechanisms, is unclear...
March 11, 2024: Phytomedicine
https://read.qxmd.com/read/38492223/neutrophil-inflicted-vasculature-damage-suppresses-immune-mediated-optic-nerve-regeneration
#17
JOURNAL ARTICLE
Ryan Passino, Matthew C Finneran, Hannah Hafner, Qian Feng, Lucas D Huffman, Xiao-Feng Zhao, Craig N Johnson, Riki Kawaguchi, Juan A Oses-Prieto, Alma L Burlingame, Daniel H Geschwind, Larry I Benowitz, Roman J Giger
In adult mammals, injured retinal ganglion cells (RGCs) fail to spontaneously regrow severed axons, resulting in permanent visual deficits. Robust axon growth, however, is observed after intra-ocular injection of particulate β-glucan isolated from yeast. Blood-borne myeloid cells rapidly respond to β-glucan, releasing numerous pro-regenerative factors. Unfortunately, the pro-regenerative effects are undermined by retinal damage inflicted by an overactive immune system. Here, we demonstrate that protection of the inflamed vasculature promotes immune-mediated RGC regeneration...
March 14, 2024: Cell Reports
https://read.qxmd.com/read/38492117/fabrication-strategies-for-chiral-self-assembly-surface
#18
REVIEW
Xiaohui Niu, Mei Yuan, Rui Zhao, Luhua Wang, Yongqi Liu, Hongfang Zhao, Hongxia Li, Xing Yang, Kunjie Wang
Chiral self-assembly is the spontaneous organization of individual building blocks from chiral (bio)molecules to macroscopic objects into ordered superstructures. Chiral self-assembly is ubiquitous in nature, such as DNA and proteins, which formed the foundation of biological structures. In addition to chiral (bio) molecules, chiral ordered superstructures constructed by self-assembly have also attracted much attention. Chiral self-assembly usually refers to the process of forming chiral aggregates in an ordered arrangement under various non-covalent bonding such as H-bond, π-π interactions, van der Waals forces (dipole-dipole, electrostatic effects, etc...
March 16, 2024: Mikrochimica Acta
https://read.qxmd.com/read/38491706/mixing-twist-bend-and-ferroelectric-nematic-liquid-crystals
#19
JOURNAL ARTICLE
Abinash Barthakur, Bidisha Bag, Santhegudda Jayaramappa Shivaraja, Jakub Karcz, Przemyslaw Kula, Surajit Dhara
Twist-bend (N_{tb}) and ferroelectric (N_{F}) nematic liquid crystals exhibit several novel effects and new physical properties. Here, we report experimental studies on the phase diagram and some physical properties of binary mixtures of CB9CB and RM734 mesogens. Both N-N_{tb} and N-N_{F} phase transition temperatures and the corresponding enthalpies decrease significantly and, eventually, these transitions disappear at some intermediate compositions, stabilizing wide nematic phase (N). Temperature-dependent birefringence several degrees above the N-N_{tb} phase transition shows strong director tilt fluctuations...
February 2024: Physical Review. E
https://read.qxmd.com/read/38491695/convection-of-monodisperse-particles-in-a-highly-filled-rotating-cylinder
#20
JOURNAL ARTICLE
Shoichi Yoneta, Hiroyuki Ebata, Shio Inagaki
We investigate the occurrence of spontaneous convection in a coaxial cylinder highly filled with monodisperse spheres. To analyze the flow field noninvasively, initial pulses consisting of colored particles are placed at equal intervals. By analyzing the spatiotemporal distribution of these pulses, we obtained axial velocity profiles for both the surface and subsurface regions. Our advection-diffusion equations with steady advection terms incorporate experimentally obtained axial velocity profiles in the surface layer, while the rest of the components are estimated using azimuthal symmetry and volume conservation...
February 2024: Physical Review. E
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