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https://www.readbyqxmd.com/read/29767550/effectiveness-of-adjunct-psychotherapy-for-cancer-treatment-a-review
#1
YokeYong Chen, Mahadir Ahmad
Psychotherapies were offered to alleviate psychological and physical symptoms; however, most psychological interventions were only delivered after cancer treatment. Newly diagnosed cancer patients experienced psychological distress while waiting for treatments. This review paper focused on randomized control trial studies, aimed to investigate the effectiveness of psychological intervention among newly diagnosed cancer patients. Eight randomized control trial papers were found in recent 10 years period through electronic database...
May 16, 2018: Future Oncology
https://www.readbyqxmd.com/read/29759891/the-putative-role-of-oxidative-stress-and-inflammation-in-the-pathophysiology-of-sleep-dysfunction-across-neuropsychiatric-disorders-focus-on-chronic-fatigue-syndrome-bipolar-disorder-and-multiple-sclerosis
#2
REVIEW
Gerwyn Morris, Brendon Stubbs, Cristiano A Köhler, Ken Walder, Anastasiya Slyepchenko, Michael Berk, André F Carvalho
Sleep and circadian abnormalities are prevalent and burdensome manifestations of diverse neuro-immune diseases, and may aggravate the course of several neuropsychiatric disorders. The underlying pathophysiology of sleep abnormalities across neuropsychiatric disorders remains unclear, and may involve the inter-play of several clinical variables and mechanistic pathways. In this review, we propose a heuristic framework in which reciprocal interactions of immune, oxidative and nitrosative stress, and mitochondrial pathways may drive sleep abnormalities across potentially neuroprogressive disorders...
April 4, 2018: Sleep Medicine Reviews
https://www.readbyqxmd.com/read/29759136/characterization-of-sleep-pattern-and-neuro-immune-endocrine-markers-at-24-hour-post-injection-of-a-single-low-dose-of-lipopolysaccharide-in-male-wistar-rats
#3
Francisco Nachón-García, Gabriela Hurtado-Alvarado, Mario E Acosta-Hernández, Carolina Peña-Escudero, Sergio Priego-Fernández, Samantha Alvarez-Herrera, Enrique Becerril-Villanueva, Gilberto Pérez-Sánchez, Lenin Pavón, Fabio García-García
The long-term effect of immune system activation by a low dose of lipopolysaccharide on neuro-immune-endocrine regulation is unclear. Sleep, neurotransmitter concentrations, TNF-α, and corticosterone levels were evaluated in male Wistar rats implanted with conventional sleep recordings. In this work, we found that REM sleep was reduced in the first 4 h post-injection, without affecting the total sleep time, while adrenaline concentration was reduced in the hippocampus at 24 h post-injection of LPS. Our results demonstrated that, although the acute immune response was not evident 24 h after the injection of LPS, it was able to promote the reduction of AD in the hippocampus, which may explain in part the depressive behavior reported in rodents following LPS administration...
July 15, 2018: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/29755400/intermittent-hypoxia-is-associated-with-high-hypoxia-inducible-factor-1%C3%AE-but-not-high-vascular-endothelial-growth-factor-cell-expression-in-tumors-of-cutaneous-melanoma-patients
#4
Isaac Almendros, Miguel Ángel Martínez-García, Francisco Campos-Rodríguez, Erica Riveiro-Falkenbach, José L Rodríguez-Peralto, Eduardo Nagore, Antonio Martorell-Calatayud, Luis Hernández Blasco, Jose Bañuls Roca, Eusebi Chiner Vives, Alicia Sánchez-de-la-Torre, Jorge Abad-Capa, Josep Maria Montserrat, Amalia Pérez-Gil, Valentín Cabriada-Nuño, Irene Cano-Pumarega, Jaime Corral-Peñafiel, Trinidad Diaz-Cambriles, Olga Mediano, Joan Dalmau-Arias, Ramon Farré, David Gozal
Epidemiological associations linking between obstructive sleep apnea and poorer solid malignant tumor outcomes have recently emerged. Putative pathways proposed to explain that these associations have included enhanced hypoxia inducible factor (HIF)-1α and vascular endothelial growth factor (VEGF) cell expression in the tumor and altered immune functions via intermittent hypoxia (IH). Here, we examined relationships between HIF-1α and VEGF expression and nocturnal IH in cutaneous melanoma (CM) tumor samples...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29746692/increased-risk-of-upper-respiratory-infection-in-military-recruits-who-report-sleeping-less-than-6-h-per-night
#5
Laurel M Wentz, Mark D Ward, Claire Potter, Samuel J Oliver, Sarah Jackson, Rachel M Izard, Julie P Greeves, Neil P Walsh
Introduction: Professional sleep associations recommend 7-9 h of sleep per night for young adults. Habitually sleeping less than 6 h per night has been shown to increase susceptibility to common cold in otherwise healthy, adult civilians. However, no investigations have examined the importance of sleep duration on upper respiratory tract infection (URTI) and loss of training days in military recruits. The purpose of this study was to describe self-reported sleep duration in a large cohort of military recruits and to assess the relationship between reported sleep duration and incidence of URTI's...
May 9, 2018: Military Medicine
https://www.readbyqxmd.com/read/29739334/exploring-gene-expression-biomarker-candidates-for-neurobehavioral-impairment-from-total-sleep-deprivation
#6
Hilary A Uyhelji, Doris M Kupfer, Vicky L White, Melinda L Jackson, Hans P A Van Dongen, Dennis M Burian
BACKGROUND: Although sleep deprivation is associated with neurobehavioral impairment that may underlie significant risks to performance and safety, there is no reliable biomarker test to detect dangerous levels of impairment from sleep loss in humans. This study employs microarrays and bioinformatics analyses to explore candidate gene expression biomarkers associated with total sleep deprivation (TSD), and more specifically, the phenotype of neurobehavioral impairment from TSD. Healthy adult volunteers were recruited to a sleep laboratory for seven consecutive days (six nights)...
May 9, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29738302/care-and-treatment-of-a-rare-mycobacterium-avium-complex-infected-wound-a-case-report
#7
Min Wei, Qixia Jiang, Jiandong Wang
An unusual presentation of Mycobacterium avium complex (MAC), unlikely to be encountered in an outpatient dermatology setting, was diagnosed in a patient without an immunodeficiency. A 47-year-old woman, who was immunocompetent and had no risk factors, presented with a full-thickness, infected wound (large amounts of purulent exudate and severe pain) on her back, which had been present for two months. She was diagnosed as having an MAC infection, using a DNA microarray chip method. The patient underwent wound drainage and a fresh silver-containing dressing was applied daily for two months...
May 2, 2018: Journal of Wound Care
https://www.readbyqxmd.com/read/29735673/simulated-night-shift-work-induces-circadian-misalignment-of-the-human-peripheral-blood-mononuclear-cell-transcriptome
#8
Laura Kervezee, Marc Cuesta, Nicolas Cermakian, Diane B Boivin
Misalignment of the endogenous circadian timing system leads to disruption of physiological rhythms and may contribute to the development of the deleterious health effects associated with night shift work. However, the molecular underpinnings remain to be elucidated. Here, we investigated the effect of a 4-day simulated night shift work protocol on the circadian regulation of the human transcriptome. Repeated blood samples were collected over two 24-hour measurement periods from eight healthy subjects under highly controlled laboratory conditions before and 4 days after a 10-hour delay of their habitual sleep period...
May 7, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29731875/circadian-locomotor-output-cycles-kaput-affects-the-proliferation-and-migration-of-breast-cancer-cells-by-regulating-the-expression-of-e-cadherin-via-iq-motif-containing-gtpase-activating-protein-1
#9
Xiaoxue Li, Siyang Wang, Shuhong Yang, Junjie Ying, Hang Yu, Chunlei Yang, Yanyou Liu, Yuhui Wang, Shuting Cheng, Jing Xiao, Huiling Guo, Zhou Jiang, Zhengrong Wang
The circadian rhythm regulates numerous physiological activities, including sleep and wakefulness, behavior, immunity and metabolism. Previous studies have demonstrated that circadian rhythm disorder is associated with the occurrence of tumors. Responsible for regulating a number of functions, the Circadian locomotor output cycles kaput ( Clock ) gene is one of the core regulatory genes of circadian rhythm. The Clock gene has also been implicated in the occurrence and development of tumors in previously studies...
May 2018: Oncology Letters
https://www.readbyqxmd.com/read/29693583/adenylate-cyclases-of-trypanosoma-brucei-environmental-sensors-and-controllers-of-host-innate-immune-response
#10
REVIEW
Didier Salmon
Trypanosoma brucei , etiological agent of Sleeping Sickness in Africa, is the prototype of African trypanosomes, protozoan extracellular flagellate parasites transmitted by saliva ( Salivaria ). In these parasites the molecular controls of the cell cycle and environmental sensing are elaborate and concentrated at the flagellum. Genomic analyses suggest that these parasites appear to differ considerably from the host in signaling mechanisms, with the exception of receptor-type adenylate cyclases (AC) that are topologically similar to receptor-type guanylate cyclase (GC) of higher eukaryotes but control a new class of cAMP targets of unknown function, the cAMP response proteins (CARPs), rather than the classical protein kinase A cAMP effector (PKA)...
April 25, 2018: Pathogens
https://www.readbyqxmd.com/read/29673929/sleep-disorders-in-adolescents-and-young-adults-insights-into-types-relationship-to-obesity-and-high-altitude-and-possible-lines-of-management
#11
REVIEW
Ahmed M Kabel, Amani M Al Thumali, Khayriah A Aldowiala, Raghad D Habib, Shoroq S Aljuaid, Huda A Alharthi
A sleep disorder is a medical disorder of the sleep pattern of a person that may be serious enough to interfere with normal physical, mental and emotional functioning. Disruptions in sleep can be caused by a variety of causes, from teeth grinding to night terrors. Sleep disorders are usually prevalent among adolescents and young adults, possibly due to factors related to life style, dietary habits, hormonal and emotional disturbances. Other factors that may precipitate sleep disorders include environmental, psychological and genetic factors...
April 11, 2018: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/29662454/the-biological-clock-a-pivotal-hub-in-non-alcoholic-fatty-liver-disease-pathogenesis
#12
REVIEW
Gianluigi Mazzoccoli, Salvatore De Cosmo, Tommaso Mazza
Non-alcoholic fatty liver disease (NAFLD) is the most frequent hepatic pathology in the Western world and may evolve into steatohepatitis (NASH), increasing the risk of cirrhosis, portal hypertension and hepatocellular carcinoma. NAFLD derives from the accumulation of hepatic fat due to discrepant free fatty acid metabolism. Other factors contributing to this are deranged nutrients and bile acids fluxes as well as alterations in nuclear receptors, hormones, and intermediary metabolites, which impact on signaling pathways involved in metabolism and inflammation...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29596659/the-degree-of-radiation-induced-dna-strand-breaks-is-altered-by-acute-sleep-deprivation-and-psychological-stress-and-is-associated-with-cognitive-performance-in-humans
#13
Maria Moreno-Villanueva, Gudrun von Scheven, Alan Feiveson, Alexander Bürkle, Honglu Wu, Namni Goel
Study Objectives: Sleep deprivation is associated with impaired immune responses, cancer, and morbidity and mortality, and can degrade cognitive performance, although individual differences exist in such responses. Sleep deprivation induces DNA strand breaks and DNA base oxidation in animals, and psychological stress is associated with increased DNA damage in humans. It remains unknown whether sleep deprivation or psychological stress in humans affects DNA damage response from environmental stressors, and whether these responses predict cognitive performance during sleep deprivation...
March 27, 2018: Sleep
https://www.readbyqxmd.com/read/29568502/associations-between-atopic-dermatitis-and-other-disorders
#14
REVIEW
Jonathan I Silverberg
Atopic dermatitis is a heterogeneous, chronic, and inflammatory skin disease that is associated with a profound symptom burden. Recent studies have demonstrated associations between atopic dermatitis and a number of multi-organ and systemic disorders. The origin of these comorbid conditions is likely multifactorial, with combined effects of skin-barrier disruption, immune dysregulation, intense symptoms, and iatrogenic complications. Some of these comorbid conditions appear to be related to the underlying severity of atopic dermatitis and inadequate disease control...
2018: F1000Research
https://www.readbyqxmd.com/read/29558822/effects-of-ahcc%C3%A2-on-immune-and-stress-responses-in-healthy-individuals
#15
Jun Takanari, Atsuya Sato, Hideaki Waki, Shogo Miyazaki, Kazuo Uebaba, Tatsuya Hisajima
AHCC® is a functional food from the basidiomycete Lentinula edodes. We evaluated the effects of AHCC® on subjects under different kinds of stress and at rest. Physical stress was imposed using an active standing test, known as Schellong's test. Sympathetic nervous activity in the standing position was significantly greater in AHCC®-treated subjects than in a placebo group. In contrast, AHCC® significantly increased parasympathetic nervous activity at rest. Under mental stress, AHCC® increased sympathetic nervous activity, with no difference in the parasympathetic nervous system...
January 2018: Journal of evidence-based integrative medicine
https://www.readbyqxmd.com/read/29556959/neurogenic-inflammation-in-fibromyalgia
#16
REVIEW
Geoffrey Littlejohn, Emma Guymer
Fibromyalgia is a high impact chronic pain disorder with a well-defined and robust clinical phenotype. Key features include widespread pain and tenderness, high levels of sleep disturbance, fatigue, cognitive dysfunction and emotional distress. Abnormal processing of pain and other sensory input occurs in the brain, spinal cord and periphery and is related to the processes of central and peripheral sensitization. As such, fibromyalgia is deemed to be one of the central sensitivity syndromes. There is increasing evidence of neurogenically derived inflammatory mechanisms occurring in the peripheral tissues, spinal cord and brain in fibromyalgia...
March 19, 2018: Seminars in Immunopathology
https://www.readbyqxmd.com/read/29548630/sleep-apnea-morbidity-a-consequence-of-microbial-immune-cross-talk
#17
REVIEW
Nuria Farré, Ramon Farré, David Gozal
Obstructive Sleep Apnea (OSA) has emerged as a highly prevalent public health problem that imposes important mid-term and long-term consequences, namely cardiovascular, metabolic, cognitive and cancer-related alterations. OSA is characterized by increased upper airway resistance, alveolar hypoventilation, and recurrent upper airway obstruction during sleep. Recurrent collapse of the upper airway develops with sleep onset, and is associated with both intermittent hypoxemia and sleep fragmentation. The microbiome is a vast and complex polymicrobial ecosystem that coexists with the human organism, and has been identified as playing significant roles in the development of host immunological phenotypes...
March 13, 2018: Chest
https://www.readbyqxmd.com/read/29528406/supplementation-of-bacillus-subtilis-based-probiotic-reduces-heat-stress-related-behaviors-and-inflammatory-response-in-broiler-chickens
#18
W C Wang, F F Yan, J Y Hu, O A Amen, H W Cheng
Probiotics reduce stress-related inflammation and abnormal behaviors in humans and rodents via regulation of the microbiota-gut-brain axis. The objective of this study was to determine if probiotic, Bacillus subtilis, has similar functions in broiler chickens under heat stress (HS). Two hundred forty 1-day-old broiler chicks were assigned to 48 pens with 4 treatments: Thermoneutral (TN)-RD (regular diet), TN-PD (the regular diet mixed with 1×106 CFU/g feed probiotic), HS-RD and HS-PD. Probiotic (Sporulin®) was fed from day 1; and HS at 32 ºC for 10 h daily was initiated at day 15...
March 8, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/29528164/thioester-containing-proteins-in-the-tsetse-fly-glossina-and-their-response-to-trypanosome-infection
#19
I Matetovici, J Van Den Abbeele
Thioester-containing proteins (TEPs) are conserved proteins with a role in innate immune immunity. In the current study, we characterized the TEP family in the genome of six tsetse fly species (Glossina spp.). Tsetse flies are the biological vectors of several African trypanosomes, which cause sleeping sickness in humans or nagana in livestock. The analysis of the tsetse TEP sequences revealed information about their structure, evolutionary relationships and expression profiles under both normal and trypanosome infection conditions...
March 12, 2018: Insect Molecular Biology
https://www.readbyqxmd.com/read/29512449/sodium-oxybate-treatment-in-pediatric-type-1-narcolepsy
#20
Monica Moresco, Fabio Pizza, Elena Antelmi, Giuseppe Plazzi
Narcolepsy type 1 (NT1) is a rare chronic neurologic disorder characterized by excessive daytime sleepiness, cataplexy, sleep paralysis, hallucinations and disrupted nocturnal sleep, usually with onset during childhood/adolescence. Pediatric NT1 is associated with limitations on children's activities and achievements, especially poor performance at school, difficulty with peers due to disease symptoms and comorbidities including depression, obesity, and precocious puberty. NT1 disease is caused by the selective loss of hypocretin-producing neurons in the lateral hypothalamus, most probably related to an autoimmune pathophysiology...
March 5, 2018: Current Drug Metabolism
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