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bioresorbable vascular scaffold

Takao Sato, John Jose, Mohamed El-Mawardy, Dmitriy S Sulimov, Ralph Tölg, Gert Richardt, Mohamed Abdel-Wahab
Heterogeneity of neointimal thickness is observed after drug-eluting stents implantation in bifurcation lesions (BL). We evaluated the vascular response of everolimus-eluting bioresorbable scaffold (BRS) struts deployed at BL using optical coherence tomography (OCT). 50 patients (64 scaffolds) underwent follow-up OCT after BRS implantation. Cross-sectional areas of each BL with a side branch more than 1.5 mm were analyzed using OCT every 200 µm. All images were divided into three regions according to shear stress: the 1/2 circumference of the vessel opposite to the ostium (OO), the vessel wall adjacent to the ostium (AO) and the side-branch ostium (SO)...
October 18, 2016: International Journal of Cardiovascular Imaging
Kevin O'Gallagher, Roberto Nerla, Jonathan Hill, Jonathan Byrne
No abstract text is available yet for this article.
October 20, 2016: EuroIntervention
Akihito Tanaka, Azeem Latib, Hiroyoshi Kawamoto, Richard J Jabbour, Katsumasa Sato, Tadashi Miyazaki, Toru Naganuma, Antonio Mangieri, Matteo Pagnesi, Claudio Montalto, Alaide Chieffo, Mauro Carlino, Matteo Montorfano, Antonio Colombo
AIMS: It has become clearly apparent that in comparison to metallic stents, bioresorbable vascular scaffold (BVS) require specific implantation techniques. The aim of this study was to investigate outcomes following BVS implantation using a dedicated strategy for optimal deployment. METHODS AND RESULTS: 400 consecutive lesions (264 patients) treated with Absorb BVS were analyzed. All procedures were performed based on the following principles: 1) aggressive lesion preparation; 2) high-pressure post-dilation; and 3) a low threshold for intravascular imaging...
October 18, 2016: EuroIntervention
Giuseppe Tarantini, Francesco Saia, Piera Capranzano, Bernardo Cortese, Marco Mojoli, Giacomo Boccuzzi, Andrea Cuculo, Salvatore Geraci, Alessio Mattesini, Jacopo Oreglia, Francesco Summaria, Luca Testa, Sergio Berti, Giovanni Esposito, Alessio La Manna, Ugo Limbruno, Alfredo Marchese, Ciro Mauro, Fabio Tarantino, Alessandro Salvi, Gennaro Santoro, Ferdinando Varbella, Roberto Violini, Giuseppe Musumeci
Drug-eluting stents (DES) are the current gold standard for percutaneous treatment of coronary artery disease. However, DES are associated with a non-negligible risk of long-term adverse events related to persistence of foreign material in the coronary artery wall. In addition, DES implantation causes permanent caging of the native vessel, thus impairing normal vasomotricity and the possibility of using non-invasive coronary imaging or preforming subsequent bypass surgery. On the contrary, coronary bioresorbable stents (BRS) may provide temporary mechanical support to coronary wall without compromising the subsequent recovery of normal vascular physiology, and have the potential to prevent late adverse events related to permanent elements...
October 2016: Giornale Italiano di Cardiologia
Yohei Sotomi, Yoshinobu Onuma, Jouke Dijkstra, Jeroen Eggermont, Shengnan Liu, Erhan Tenekecioglu, Yaping Zeng, Taku Asano, Robbert J de Winter, Jeffrey J Popma, Ken Kozuma, Kengo Tanabe, Patrick W Serruys, Takeshi Kimura
BACKGROUND: The optimal implantation technique for the bioresorbable scaffold (Absorb, Abbott Vascular) is still a matter of debate. The purpose of the present study was to evaluate the effect of implantation technique on strut embedment and scaffold expansion.Methods and Results:Strut embedment depth and scaffold expansion index assessed by optical coherence tomography (OCT) (minimum scaffold area/reference vessel area) were evaluated in the ABSORB Japan trial (OCT subgroup: 87 lesions) with respect to implantation technique using either quantitative coronary angiography (QCA) or OCT...
October 8, 2016: Circulation Journal: Official Journal of the Japanese Circulation Society
Muhammad Muzaffar Mahmood, David Austin
Spontaneous coronary artery dissection (SCAD) is an uncommon but important cause of acute coronary syndrome. The diagnosis of SCAD by an angiogram alone can be challenging and the increasing use of intracoronary imaging has proven an invaluable diagnostic adjunct in this regard. The appropriate initial management of SCAD has been a matter of significant debate. Owing to frequent spontaneous healing of coronary dissection and a higher risk of complications with percutaneous coronary intervention (PCI) in the setting of SCAD, a default approach of mechanical revascularization is not recommended...
September 18, 2016: Cardiovascular Revascularization Medicine: Including Molecular Interventions
Jiang Ming Fam, Johannes N van Der Sijde, Antonios Karanasos, Cordula Felix, Roberto Diletti, Nicolas van Mieghem, Peter de Jaegere, Felix Zijlstra, Robert Jan van Geuns, Evelyn Regar
OBJECTIVES: The acute expansion of bioresorbable vascular scaffolds (BRS) and drug-eluting stents (DES) in lesions with different extent of calcification was compared by Optical Coherence Tomography (OCT). BACKGROUND: The acute mechanical performance of polymeric BRS in calcified lesions is poorly understood. METHODS: Acute device performance in lesions treated with either BRS(N = 50) or DES (N = 50) was compared using Optical Coherence Tomography (OCT)...
October 7, 2016: Catheterization and Cardiovascular Interventions
Ajay Yadlapati, Mark Gajjar, Daniel R Schimmel, Mark J Ricciardi, James D Flaherty
ST-elevation myocardial infarction (STEMI), which constitutes nearly 25-40 % of current acute myocardial infarction (AMI) cases, is a medical emergency that requires prompt recognition and treatment. Since the 2013 STEMI practice guidelines, a wealth of additional data that may further advance optimal STEMI practices has emerged. These data highlight the importance of improving patient treatment and transport algorithms for STEMI from non-primary percutaneous coronary intervention (PCI) centers. In addition, a focus on the reduction of total pain-to-balloon (P2B) times rather than simply door-to-balloon (D2B) times may further improve outcomes after primary PCI for STEMI...
October 6, 2016: Internal and Emergency Medicine
Antonio Enrique Gómez Menchero, Santiago Jesús Camacho Freire, José Francisco Díaz Fernández, Jessica Roa Garrido, Javier León Jiménez, Rosa Cardenal Piris
A patient presented with an inferior non-ST segment elevation myocardial infarction and a tight lesion on the distal right coronary artery. After stent implantation, a large scaffold malapposition was observed by optical coherence tomography. This case emphasizes the importance of not expanding a bioresorbable vascular scaffold more than 0.5 mm over its nominal size.
October 2016: Journal of Invasive Cardiology
Yanping Cheng, Pawel Gasior, Masahiko Shibuya, Kamal Ramzipoor, Chang Lee, Edward A Estrada, Daniell Dokko, Jenn C McGregor, Gerard B Conditt, Greg L Kaluza, Juan F Granada
BACKGROUND: Clinically available bioresorbable scaffolds (BRS) rely on polymer crystallinity to achieve mechanical strength resulting in limited overexpansion capabilities and structural integrity when exposed to high-loading conditions. We aimed to evaluate the biomechanical behavior and vascular healing profile of a novel, sirolimus-eluting, high-molecular-weight, amorphous poly-l-lactic acid-based BRS (Amaranth BRS). METHODS AND RESULTS: In vitro biomechanical testing was performed under static and cyclic conditions...
October 2016: Circulation. Cardiovascular Interventions
Tadahisa Sugiura, Shuhei Tara, Hidetaka Nakayama, Tai Yi, Yong-Ung Lee, Toshihiro Shoji, Christopher K Breuer, Toshiharu Shinoka
OBJECTIVE: Bioresorbable vascular grafts are biologically active grafts that are entirely reconstituted by host-derived cells through an inflammation-mediated degradation process. Calcification is a detrimental condition that can severely affect graft performance. Therefore, prevention of calcification is of great importance to the success of bioresorbable arterial vascular grafts. The objective of this study was to test whether fast-degrading (FD) bioresorbable arterial grafts with high cellular infiltration will inhibit calcification of grafts...
September 26, 2016: Journal of Vascular Surgery
Ciro Indolfi, Salvatore De Rosa, Antonio Colombo
The introduction of percutaneous treatment of coronary artery stenosis with balloon angioplasty was the first revolution in interventional cardiology; the advent of metallic coronary stents (bare and drug-eluting) marked the second and third revolutions. However, the latest generation of drug-eluting stents is limited by several factors. Permanent vessel caging impairs arterial physiology, and the incidence of very late stent thrombosis - although lower with the second generation than with the first generation of drug-eluting stents - remains a major concern...
September 29, 2016: Nature Reviews. Cardiology
Haci Murat Gunes, Filiz Kizilirmak Yılmaz, Tayyar Gokdeniz, Gultekin Gunhan Demir, Ekrem Guler, Gamze Babur Guler, Oğuz Karaca, Beytullah Cakal, Ersin İbişoğlu, Bilal Boztosun
OBJECTIVE: The aim of the present study was to investigate the relationship between glomerular filtration rate (GFR) and acute post-scaffold recoil (PSR) in patients undergoing bioresorbable scaffold (BVS) implantation. METHODS: We included 130 patients who underwent everolimus-eluting BVS device (Absorb BVS; Abbott Vascular, Santa Clara, CA, USA) or the novolimus-eluting BVS device (Elixir Medical Corporation) implantations for single or multi-vessel disease. Clinical, angiographic variables and procedural characteristics were defined and pre-procedural GFR was calculated for each patient...
September 20, 2016: International Journal of Cardiology
Artemis Ailianou, Karthik Ramachandran, Mary Beth Kossuth, James Paul Oberhauser, Julia A Kornfield
Poly(l-lactide) (PLLA) is the structural material of the first clinically approved bioresorbable vascular scaffold (BVS), a promising alternative to permanent metal stents for treatment of coronary heart disease. BVSs are transient implants that support the occluded artery for 6 mo and are completely resorbed in 2 y. Clinical trials of BVSs report restoration of arterial vasomotion and elimination of serious complications such as late stent thrombosis. It is remarkable that a scaffold made from PLLA, known as a brittle polymer, does not fracture when crimped onto a balloon catheter or during deployment in the artery...
September 26, 2016: Proceedings of the National Academy of Sciences of the United States of America
Bernardo Cortese, Dario Buccheri
No abstract text is available yet for this article.
September 17, 2016: International Journal of Cardiology
Jin Ho Lee, Dong Kyun Woo, Tae Ho Kim, Jun Goo Kang, Jeong-Won Yun, Jin-Ho Park, Bong-Wook Park, Young-Hoon Kang, Gyu-Jin Rho, Si-Jung Jang, Ji-Sung Park, Hee-Chun Lee, Young Min Yoon, Tae Sung Hwang, Deok Ryong Kim, Sun-Chul Hwang, Dong Hoon Lee, Ho Young Kim, Se Heang Oh, June-Ho Byun
Polycaprolactone (PCL) is a biodegradable polyester that is bioresorbable and biocompatible, and is widely used in medical fields. This study examines in vitro and in vivo osteogenic activities of cultured human periosteum-derived osteoblasts (POs) seeded into growth factor (bone morphogenic protein 2 [BMP-2] or vascular endothelial growth factor [VEGF])-releasing scaffolds of PCL beads coated with Pluronic F127. Each growth factor immobilized in the PCL/F127 is cumulatively released from the beads for more than 40 days (up to 3...
September 19, 2016: Journal of Biomedical Materials Research. Part A
Wei-Chieh Lee, Hsiu-Yu Fang, Pei-Hsun Sung, Kuo-Ho Yeh, Chiung-Jen Wu
No abstract text is available yet for this article.
September 18, 2016: EuroIntervention
Nicolas Foin, Renick Lee, Christos Bourantas, Alessio Mattesini, Nicole Soh, Jie En Lim, Ryo Torii, Jaryl Ng, Leo Hwa Liang, Gianluca Caiazzo, Enrico Fabris, Dogu Kilic, Yoshinobu Onuma, Adrian F Low, Sukh Nijjer, Sayan Sen, Ricardo Petraco, Rasha Al Lamee, Justin E Davies, Carlo Di Mario, Philip Wong, Patrick W Serruys
AIMS: This study aimed to compare the acute expansion behaviour of a polymer-based bioresorbable scaffold and a second-generation metallic DES platform in a realistic coronary artery lesion model. Experimental mechanical data with conventional methods have so far shown little difference between metallic stents and currently available polymer-based bioresorbable scaffolds (BRS). Nevertheless, differences in acute results have been observed in clinical studies comparing BRS directly with metallic DES platforms...
September 18, 2016: EuroIntervention
Carlos Collet, Taku Asano, Yohei Sotomi, Rafael Cavalcante, Yosuke Miyazaki, Yaping Zeng, Karthik Tummala, Bojan Stanetic, Jan Tijssen, Robbert De Winter, Yoshinobu Onuma, Davide Capodanno, Patrick W Serruys
INTRODUCTION: To determine the incidence of bioresorbable vascular scaffold (ABSORB BVS, Abbott Vascular) thrombosis. EVIDENCE ACQUISITION: A systematic review of the published literature between October 2012 and August 2016 was performed using PubMed, Medline and Embase databases. Articles published in the English language that reported the rate of bioresorbable scaffold thrombosis according to Academic Research Consortium criteria were included. Titles and abstracts were screened independently by two authors and further evaluated and assessed for study details, population characteristics and scaffold thrombosis rates...
September 14, 2016: Minerva Cardioangiologica
Mohamed Farag, Nikolaos Spinthakis, Diana A Gorog, Abhiram Prasad, Keith Sullivan, Zaki Akhtar, Neville Kukreja, Manivannan Srinivasan
BACKGROUND: Differences in outcomes between bioresorbable vascular scaffold (BVS) systems and drug-eluting metal stents (DES) have not been fully evaluated. We aimed to compare clinical and angiographic outcomes in randomised studies of patients with coronary artery disease (CAD), with a secondary analysis performed among registry studies. METHODS: A meta-analysis comparing outcomes between BVS and DES in patients with CAD. Overall estimates of treatment effect were calculated with random-effects model and fixed-effects model...
2016: Open Heart
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