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Chronic lymphocytic thyroiditis

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https://www.readbyqxmd.com/read/29749344/usefulness-of-cancer-free-survival-in-estimating-the-lifetime-attributable-risk-of-cancer-incidence-from-radiation-exposure
#1
Songwon Seo, Dal Nim Lee, Young-Woo Jin, Won Jin Lee, Sunhoo Park
Risk projection models estimating the lifetime cancer risk from radiation exposure are generally based on exposure dose, age at exposure, attained age, gender, and study population-specific factors, such as baseline cancer risks and survival rates. Because such models have been mostly based on the Life Span Study cohort of Japanese atomic bomb survivors, the baseline risks and survival rates in the target population should be considered when applying the cancer risk from Japanese atomic bomb survivors. The survival function used in risk projection models that are commonly used in radiological protection field to estimate cancer risk from medical or occupational exposure is based on all-cause mortality...
May 11, 2018: Journal of Radiological Protection: Official Journal of the Society for Radiological Protection
https://www.readbyqxmd.com/read/29749329/is-celiac-disease-misdiagnosed-in-children-with-functional-constipation
#2
Sezin Akman, Özlem Şahaloğlu, Ceyhun Dalkan, Nerin Nadir Bahçeciler, Çiğdem Arıkan
BACKGROUND/AIMS: Functional constipation is one of the common problems in childhood, and it comprises approximately 5% of the pediatric outpatient clinical applications. On the other hand, celiac disease (CD) is an immune enteropathy with the prevalence between 1/150 and 1/200. In addition to the classical symptoms of the disease such as diarrhea and weight loss, the incidence of atypical symptoms is increasing. This study aims to determine the prevalence of CD in patients with chronic constipation...
March 2018: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
https://www.readbyqxmd.com/read/29686785/primary-thyroid-maltoma-a-rare-diagnosis-of-an-unassuming-thyroid-nodule
#3
Pragya Shrestha, Kimberly Aderhold, Sharon Swierczynski, Catherine Lin, Ronald Herb
Primary thyroid lymphoma, although a rare malignancy, can arise in common chronic inflammatory conditions such as Hashimoto's thyroiditis. Incidental finding of a thyroid nodule with chronic thyroid inflammation warrants further investigation. Early detection of malignancy can play a vital role in improved outcomes. We report a case of a 60-year-old male who presented to the clinic for a routine visit. An enlarged, firm, non-tender thyroid gland was appreciated on exam with high thyroid stimulating hormone (TSH) level...
2018: Journal of Community Hospital Internal Medicine Perspectives
https://www.readbyqxmd.com/read/29651624/in-papillary-thyroid-carcinoma-expression-by-immunohistochemistry-of-braf-v600e-pd-l1-and-pd-1-is-closely-related
#4
Yanhua Bai, Ting Guo, Xiaozheng Huang, Qi Wu, Dongfeng Niu, Xinqiang Ji, Qin Feng, Zhongwu Li, Kennichi Kakudo
Immune checkpoint inhibitor therapies targeting PD-L1/PD-1 have been shown to be effective in treating several types of human cancer. In papillary thyroid carcinoma (PTC), little is known about the expression of PD-L1/PD-1 in the tumor microenvironment or its potential correlation with BRAF V600E mutation status. In this study, we examined the expression of PD-L1, PD-1, and BRAF V600E in PTC by immunohistochemistry and investigated the clinical significance of expression status. We studied the expression of PD-L1, PD-1, and BRAF V600E by immunohistochemical staining in 110 cases of PTC with a diameter > 1 cm...
April 12, 2018: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/29619749/decreased-staging-of-differentiated-thyroid-cancer-in-patients-with-chronic-lymphocytic-thyroiditis
#5
M Borowczyk, A Janicki, G Dworacki, E Szczepanek-Parulska, M Danieluk, J Barnett, M Antonik, M Kałużna, B Bromińska, R Czepczyński, M Bączyk, K Ziemnicka, M Ruchała
PURPOSE: The biological association between chronic lymphocytic thyroiditis (CLT) and differentiated thyroid cancer (DTC) has not been elucidated yet. The aim of the study was to assess whether the presence of CLT exerts any influence on clinical or histological presentation of DTC. METHODS: Nine hundred and seven consecutive patients with DTC treated in the years 1998-2016 were divided into two groups according to the presence or absence of concomitant CLT. The statistical differences were analysed...
April 4, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29594061/effects-of-chronic-lymphocytic-thyroiditis-on-the-clinicopathological-features-of-papillary-thyroid-cancer
#6
Saleha Babli, Richard J Payne, Elliot Mitmaker, Juan Rivera
Background: The effects of chronic lymphocytic thyroiditis (CLT) on the presentation and outcome of papillary thyroid carcinoma (PTC) have long been a topic of controversy. Objective: To evaluate the effect of coexistent CLT on the clinicopathological features of PTC. Design: Retrospective study. Patients: All patients with PTC who had been followed by the 2 co-investigators (Juan Rivera and Richard J. Payne) between 2006 and 2011 were included...
March 2018: European Thyroid Journal
https://www.readbyqxmd.com/read/29549672/the-mutual-cooperation-of-blood-platelets-and-lymphocytes-in-the-development-of-autoimmune-thyroid-diseases
#7
Małgorzata Tomczyńska, Joanna Saluk-Bijak
Autoimmune thyroid diseases include several distinct clinical entities, mainly Graves' disease and Hashimoto's thyroiditis. An incompetent immune response directed against the body's own tissues, and the production of antibodies against specific cell antigens accompanied by chronic inflammation, all occur in autoimmune thyroid diseases. The autoimmune process is induced by genetic and environmental factors that are difficult to identify and generates the development of concomitant diseases in other systems...
2018: Acta Biochimica Polonica
https://www.readbyqxmd.com/read/29489971/elevated-neutrophil-to-lymphocyte-ratio-in-the-diagnosis-of-hashimoto-s-thyroiditis
#8
Gulali Aktas, Mustafa Sit, Oguz Dikbas, Hayri Erkol, Rabia Altinordu, Edip Erkus, Haluk Savli
OBJECTIVE: Hashimoto's thyroiditis (HT) is an autoimmune inflammatory disorder. The purpose of this study was to determine the neutrophil-to-lymphocyte ratio (NLR), a novel marker of inflammation, in patients with HT and to compare these values with those from healthy subjects. METHOD: A total of 154 participants were included in the study, 90 HT patients and 64 healthy volunteers. Retrospectively, demographic and laboratory data of the subjects were obtained from our institution's database...
December 2017: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/29457831/low-t3-syndrome-as-a-predictor-of-poor-prognosis-in-chronic-lymphocytic-leukemia
#9
Rui Gao, Rui-Ze Chen, Yi Xia, Jin-Hua Liang, Li Wang, Hua-Yuan Zhu, Jia- Zhu Wu, Lei Fan, Jian-Yong Li, Tao Yang, Wei Xu
Low triiodothyronine (T3) state is associated with poor prognosis in critical acute and prolonged illness. However, the information on thyroid dysfunction and cancer is limited. The aim of our study was to evaluate the prognostic value of low T3 syndrome in chronic lymphocytic leukemia (CLL). Two hundred and fifty-eight patients with detailed thyroid hormone profile at CLL diagnosis were enrolled. Low T3 syndrome was defined by low free T3 (FT3) level accompanied by normal-to-low free tetraiodothyronine (FT4) and thyroid-stimulating hormone (TSH) levels...
February 19, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29440138/rhabdomyolysis-a-rare-complication-of-hashimoto-s-thyroiditis-precipitated-by-statin-therapy
#10
Jayameena Peringat, Robin George Manappallil, Ummer Karadan
Hashimoto's thyroiditis (HT) or chronic lymphocytic thyroiditis is the most common form of primary hypothyroidism. Muscular manifestations like weakness, pain, stiffness and elevated muscle enzymes have been noticed in hypothyroidism. Statins are also known to cause myositis and rhabdomyolysis. This is a case of a middle-aged man, on statin therapy, who presented with severe muscle aches and pain and was found to have rhabdomyolysis. Further evaluation revealed an underlying HT as the culprit for his condition...
February 12, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29316976/clinical-implications-of-the-braf-mutation-in-papillary-thyroid-carcinoma-and-chronic-lymphocytic-thyroiditis
#11
Woon Won Kim, Tae Kwun Ha, Sung Kwon Bae
BACKGROUND: The purpose of this study was to examine the possible prognostics and clinicopathologic characteristics underlying the BRAFV600E mutation and papillary thyroid carcinoma (PTC) coexisting or in absence of chronic lymphocytic thyroiditis (CLT). METHODS: This study was conducted on 172 patients who had undergone total thyroidectomy or unilateral total thyroidectomy for PTC; the patients were then examined for the BRAFV600E mutation using specimens obtained after their surgery from January 2013 to August 2015...
January 9, 2018: Journal of Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/29306230/prediction-of-central-lymph-node-metastasis-in-patientswith-thyroid-papillary-microcarcinoma
#12
Şafak Akın, Duygu Yazgan Aksoy, Serkan Akın, Mehmet Kılıç, Fahri Yetişir, Miyase Bayraktar
Background/aim: The purpose of this study was to analyze the clinicopathological characteristics of patients with papillary thyroid carcinoma (PTC) and papillary thyroid microcarcinoma (PTMC) and predictive factors for central lymph node metastasis (CLNM).Materials and methods: Patients diagnosed as having PTC and PTMC were evaluated. Clinical and laboratory parameters were recorded.Results: The mean age at diagnosis was 47.3 +- 11.9 years. Of all 223 patients, 91 (40.8%) had lymph nodes removed, 29 of whom had lymph node metastasis and 24 of whom had only CLNM...
December 19, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29286493/twenty-five-years-of-the-national-academy-of-medical-sciences-of-ukraine-progress-and-priorities-for-future-of-radiation-medicine-and-biology
#13
D Bazyka
After the creation of the Academy of Medical Sciences of Ukraine in 1993 the Research Center for Radiation Medicine was among the first institutions to join the Academy (fig. 1). Estab lishing the Academy was among the first steps of the independent Ukrainian government and aimed to provide a high level health care for population. It was extremely needed for the minimization of Chornobyl medical consequences. This choice was related to a growing recognition of the scientific research in fulfilling the Сenter's mission - study of the effects of low dose radiation on human body and radiation protection of the exposed population...
December 2017: Problemy Radiat︠s︡iĭnoï Medyt︠s︡yny Ta Radiobiolohiï
https://www.readbyqxmd.com/read/29250033/one-third-of-an-archivial-series-of-papillary-thyroid-cancer-years-2007-2015-has-coexistent-chronic-lymphocytic-thyroiditis-which-is-associated-with-a-more-favorable-tumor-node-metastasis-staging
#14
Antonio Ieni, Roberto Vita, Emilia Magliolo, Mariacarmela Santarpia, Flavia Di Bari, Salvatore Benvenga, Giovanni Tuccari
The significance and impact of the coexistence of chronic lymphocytic thyroiditis (CLT) with thyroid cancer is still debated. To verify the influence of CLT on papillary thyroid cancer (PTC), we retrospectively collected 505 PTC cases and analyzed age at diagnosis, sex, size, lymph node status, and staging. We found that CLT was present in 168 PTC (33.3%). Compared with the 337 patients without CLT (non-CLT), CLT patients were younger (44.42 ± 13.72 vs. 47.21 ± 13.76 years, P  = 0.03), had smaller tumors (9...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29230715/chronic-lymphocytic-thyroiditis-clt-has-a-positive-prognostic-value-in-papillary-thyroid-cancer-ptc-patients-the-potential-key-role-of-foxp3-t-lymphocytes
#15
T Pilli, P Toti, R Occhini, M G Castagna, S Cantara, M Caselli, S Cardinale, L Barbagli, F Pacini
BACKGROUND: An impact of chronic lymphocytic thyroiditis (CLT) on papillary thyroid cancer (PTC) outcome has long been advocated but it is still controversial. PURPOSE: The aim of this study was to evaluate the prognostic value of CLT in a retrospective cohort of PTC patients and to characterize the lymphocytic subpopulations and infiltrate (LI). MATERIALS AND METHODS: We assessed 375 PTC patients, aged 45.2 ± 16.4 years, and treated with thyroidectomy and radioiodine remnant ablation, with a mean follow-up of 6...
December 11, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29136676/papillary-thyroid-cancer-and-coexisting-autoimmune-thyroiditis
#16
Franziska Veit, Dieter Graf, Saskia Momberger, Brigitte Helmich-Kapp, Ilka Ruschenburg, Anja Peters, Jochen Kussmann, Wolfgang Saeger, Kurt Werner Schmidt, Martin Toetsch, Kai Nestler, Klaus Mann
Histological findings often display an association between papillary thyroid carcinomas (PTC) and autoimmune thyroiditis (AIT) and so differ significantly from follicular thyroid carcinomas (FTC). The aim of this interdisciplinary, retrospective study was to evaluate the association of AIT in patients with PTC and FTC and a control group of benign nodular goiters. One hundred thyroidectomies with histologically confirmed differentiated thyroid carcinomas, 67 with PTC and 33 with FTC, were submitted for examination...
November 2017: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/29133889/oral-exposure-to-dibutyl-phthalate-exacerbates-chronic-lymphocytic-thyroiditis-through-oxidative-stress-in-female-wistar-rats
#17
Yang Wu, Jinquan Li, Biao Yan, Yuqing Zhu, Xudong Liu, Mingqing Chen, Dai Li, Ching-Chang Lee, Xu Yang, Ping Ma
Chronic lymphocytic thyroiditis (CLT) is a common autoimmune disorder. The possible pathogenic role and mechanism of dibutyl phthalate (DBP) in CLT is still controversial. Experiments were conducted after 35-days of oral exposure to the three concentrations of DBP or saline, and three immunizations with thyroglobulin (TG). Healthy female Wistar rats were randomly divided into ten exposure groups (n = 8 each): (A) saline control, (B) 0.5 mg/kg/d DBP, (C) 5 mg/kg/d DBP, (D) 50 mg/kg/d DBP, (E) TG-immunized group, (F) TG- combined with 0...
November 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28985747/thyroid-hemiagenesis-and-hashimoto-s-thyroditis-diagnostic-and-treatment-pitfalls
#18
Minghao Wang, Lingmi Hou, Maoshan Chen, Lin Ren, Peng Tang, Yi Zhang, Jun Jiang
BACKGROUND: Thyroid hemiagenesis (TH) is a rare congenital disease with absence of a thyroid lobe; most patients have no clinical symptoms. The etiology of TH remains unclear. In this paper, we describe a rare case of TH and congenital absence of the ipsilateral parathyroid gland, found during the operation, combined with the autoimmune disease Hashimoto's thyroiditis, also known as chronic lymphocytic thyroiditis. CASE PRESENTATION: A 31-year-old woman was admitted to our hospital because of a mass in the right neck...
October 6, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28975988/risk-factors-for-predicting-central-lymph-node-metastasis-in-papillary-thyroid-microcarcinoma-cn0-a-study-of-273-resections
#19
M Li, X-Y Zhu, J Lv, K Lu, M-P Shen, Z-L Xu, Z-S Wu
OBJECTIVE: The role of routine central lymph node dissection (CLND) for clinically central lymph node negative (CN0) papillary thyroid microcarcinoma (PTMC) remains uncertain. We aim to determine the predictive factors for central lymph node metastasis (CLNM) in papillary thyroid microcarcinoma. PATIENTS AND METHODS: A total of 273 patients diagnosed with clinically central lymph node negative PTMC from 2014 to 2016 were included. The predictive risk factors for CLNM were analyzed with respect to age, sex, tumor size, tumor multifocal, lymphadenectasis of lateral neck, capsular invasion, extra capsular spread (ECS), coexistence of chronic lymphocytic thyroiditis (Hashimoto thyroiditis, HT) and nodular goiter (NG), BRAFV600E mutation and subtype of papillary thyroid carcinoma (PTC)...
October 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28974264/pd-l1-and-pd-1-expression-are-correlated-with-distinctive-clinicopathological-features-in-papillary-thyroid-carcinoma
#20
Yanhua Bai, Dongfeng Niu, Xiaozheng Huang, Ling Jia, Qiang Kang, Fangyuan Dou, Xinqiang Ji, Weicheng Xue, Yiqiang Liu, Zhongwu Li, Qin Feng, Dongmei Lin, Kennichi Kakudo
BACKGROUND: Immune checkpoint blockade targeting PD-1/PD-L1 has shown efficacy in several types of cancers. However, the correlation between PD-L1/PD-1 expression and the specific clinicopathological features in papillary thyroid carcinoma (PTC) has not been investigated. METHODS: We examined the immunohistochemical expression of PD-L1, PD-1, and BRAF V600E on whole-tissue sections from 126 cases of primary PTC more than 1 cm in size. The correlation between the PD-L1/PD-1 expression and the clinicopathological features was evaluated...
October 3, 2017: Diagnostic Pathology
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