keyword
MENU ▼
Read by QxMD icon Read
search

choriocarcinoma

keyword
https://www.readbyqxmd.com/read/28434777/the-heat-shock-protein-60-promotes-progesterone-synthesis-in-mitochondria-of-jeg-3-cells
#1
Jessica Monreal-Flores, María Teresa Espinosa-García, Alejandro García-Regalado, Fabian Arechavaleta-Velasco, Federico Martínez
Progesterone synthesis in human placenta is essential to maintain pregnancy. The limiting step in placental progesterone synthesis is cholesterol transport from the cytoplasm to the inner mitochondrial membrane. Multiple proteins located in mitochondrial contact sites seem to play a key role in this process. Previously, our group identified the heat shock protein 60 (HSP60) as part of mitochondrial contact sites in human placenta, suggesting its participation in progesterone synthesis. Here, we examined the role of HSP60 in progesterone synthesis...
April 20, 2017: Reproductive Biology
https://www.readbyqxmd.com/read/28429716/polyembryoma-of-the-testis-a-report-of-two-cases-dominant-within-mixed-germ-cell-tumors-and-review-of-gonadal-polyembryomas
#2
REVIEW
Jennifer N Stall, Robert H Young
Two testicular mixed germ cell tumors, from men of 21 and 41 years, in which polyembryoma predominated are described. A literature review uncovered an additional five testicular and nine ovarian cases. One tumor occurred in a 60-year-old man, but all others occurred within the typical age range of gonadal germ cell tumors. One male presented with gynecomastia and one female with sexual precocity, but all otherwise had standard clinical manifestations. These tumors are typically large with non-specific gross features, but a few have a prominent hemorrhagic appearance...
April 21, 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/28428076/myricetin-suppresses-invasion-and-promotes-cell-death-in-human-placental-choriocarcinoma-cells-through-induction-of-oxidative-stress
#3
Changwon Yang, Whasun Lim, Fuller W Bazer, Gwonhwa Song
Myricetin is a bioactive compound found in a variety of vegetables and fruits, and its anti-cancer effects are well known. In this study, we confirmed that myricetin reduced proliferation of two choriocarcinoma cell lines (JAR and JEG-3) and also promoted apoptosis and regulated cell cycle progression in a dose-dependent manner in JAR and JEG-3 cells. In addition, we found that invasive and pro-angiogenic properties of malignant JAR and JEG-3 trophoblast cells were attenuated by myricetin treatment via MAPK and PI3K/AKT signaling pathways...
April 17, 2017: Cancer Letters
https://www.readbyqxmd.com/read/28423520/prognostic-role-of-programmed-death-ligand-1-pd-l1-expressing-tumor-infiltrating-lymphocytes-in-testicular-germ-cell-tumors
#4
Michal Chovanec, Zuzana Cierna, Viera Miskovska, Katarina Machalekova, Daniela Svetlovska, Katarina Kalavska, Katarina Rejlekova, Stanislav Spanik, Karol Kajo, Pavel Babal, Jozef Mardiak, Michal Mego
PURPOSE: Testicular germ cell tumors (TGCTs) are nearly universally curable malignancies. Nevertheless, standard cisplatin-based chemotherapy is not curative in a small subgroup of patients. Previously, we showed that PD-L1 overexpression is associated with worse prognosis in TGCTs, while tumor infiltrating lymphocytes (TILs) are prognostic in different types of cancer. This study aimed to evaluate the prognostic value of PD-1 and PD-L1 expressing TILs in TGCTs. RESULTS: PD-L1 positive TILs were found significantly more often in seminomas (95...
March 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28413543/primary-intracranial-choriocarcinoma-presenting-as-a-ring-enhancing-lesion-a-case-report-and-review-of-literature
#5
Mayur Sharma, Vernon Velho, Rachana Binayake, Chandranath Tiwari
We report here a rare case of primary intracranial choriocarcinoma without evidence of tumor elsewhere, presenting as a ring-enhancing lesion managed successfully in our institute (Grant Medical College and Sir J. J. Group of Hospitals, Mumbai, Maharashtra, India). A 22-year-old, right-handed housewife presented with complaints of headache, vomiting, generalized tonic-clonic seizures, and right upper limb weakness of short duration. On neurological examination, the patient was conscious, cooperative, well-oriented in time, place, and person...
January 2017: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/28411623/hemoptysis-as-primary-manifestation-in-three-women-with-choriocarcinoma-with-pulmonary-metastasis-a-case-series
#6
Wenping Zhang, Bao Liu, Jizhen Wu, Beibei Sun
BACKGROUND: Gestational choriocarcinoma is the most common gestational trophoblastic neoplasia; it is often secondary to hydatidiform mole, as well as to abortion, ectopic pregnancy, premature delivery, or term delivery. Approximately 60% of patients with choriocarcinoma develop pulmonary metastases, but for patients with a respiratory condition, choriocarcinoma with lung metastasis is a relatively rare lung cancer diagnosis. Three cases of choriocarcinoma with pulmonary metastasis who had the primary symptom of hemoptysis are described...
April 16, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28397369/incidental-primary-mediastinal-choriocarcinoma-diagnosed-by-endobronchial-ultrasound-guided-fine-needle-aspiration-in-a-patient-presenting-with-transient-ischemic-attack-and-stroke
#7
Ivo M B Francischetti, Antonio Cajigas, Mark Suhrland, Joaquim M Farinhas, Samer Khader
We describe a case of a 41-year old male patient with no significant prior medical history who presents with symptoms of Transient Ischemic Attack and stroke. Magnetic Resonance Imaging (MRI) of the brain identified areas of ischemia in the left side, and angiography showed occlusion of the left Medial Cerebral Artery (MCA). Cardiac Transthoracic Echocardiogram (TTE) for stroke evaluation incidentally noted a mediastinal abnormality leading to cancer work-up. Computer Tomography (CT) and (18) F-fluorodeoxyglucose (FDG) PET-CT scan of the chest incidentally revealed an avid 6 cm paraesophagial/subcarinal mass...
April 11, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28393093/choriocarcinoma-with-brain-lung-and-vaginal-metastases-successfully-treated-without-brain-radiation-or-intrathecal-chemotherapy-a-case-report
#8
Anja S Frost, Jonathan H Sherman, Katayoon Rezaei, Alivia Aron, Micael Lopez-Acevedo
•There is no consensus on optimal treatment for GTN and brain metastases.•Brain metastasis treated with craniotomy and intravenous, EMA-CO chemotherapy•Intravenous high-dose methotrexate may be adequate to treat brain metastases.
May 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/28377901/unusual-presentation-of-invasive-mole-a-case-report
#9
Soheila Aminimoghaddam, Andisheh Maghsoudnia
BACKGROUND: Invasive mole is responsible for most cases of localized gestational trophoblastic neoplasia. Gestational trophoblastic disease describes a number of gynecologic tumors that originate in trophoblastic layer including hydatidiform mole (complete or partial), invasive mole, choriocarcinoma, placental site trophoblastic tumor and epitheloid trophoblastic tumor. Invasive mole may arise from any pregnancy event although in most cases is diagnosed after molar pregnancy. Overall cure rate in low risk patients is nearly 100% and in high-risk patient 90%...
January 2017: Journal of Reproduction & Infertility
https://www.readbyqxmd.com/read/28365860/low-molecular-weight-hyaluronan-induces-migration-of-human-choriocarcinoma-jeg-3-cells-mediated-by-rhamm-as-well-as-by-pi3k-and-mapk-pathways
#10
Marilina Mascaró, Matías A Pibuel, Silvina L Lompardía, Mariangeles Díaz, Elsa Zotta, Maria I Bianconi, Néstor Lago, Silvina Otero, Gustavo Jankilevich, Elida Alvarez, Silvia E Hajos
Hyaluronan (HA) is the major glycosaminoglycan present in the extracellular matrix. It is produced by some tumours and promotes proliferation, differentiation and migration among others cellular processes. Gestational trophoblastic disease (GTD) is composed by non-tumour entities, such as hydatidiform mole (HM), which is the most common type of GTD and also malignant entities such as choriocarcinoma (CC) and placental site trophoblastic tumour (PSTT), being CC the most aggressive tumour. Although there is a growing understanding of GTD biology, the role of HA in the pathogenesis of this group of diseases remains largely unknown...
April 1, 2017: Histochemistry and Cell Biology
https://www.readbyqxmd.com/read/28322131/soluble-flt-1-has-cytotoxic-effects-on-bewo-choriocarcinoma-cells
#11
Michiko Yamashita, Keiichi Kumasawa, Tatsuya Miyake, Hitomi Nakamura, Tadashi Kimura
BACKGROUND: Vascular endothelial growth factor (VEGF) plays a pivotal role in angiogenesis and is overexpressed in many kinds of malignant tumors. Soluble VEGF receptor 1 (sVEGFR-1/ soluble fms-like tyrosine kinase 1 [sFlt-1]) plays a role as an inhibitor of VEGF, and an antitumor effect has been shown in several studies using sFlt-1. Recently, in addition to its antiangiogenic effect, it was reported that sFlt-1 has direct cytotoxicity. MATERIALS AND METHODS: Transfection of sFlt-1 plasmid DNA was performed in the BeWo choriocarcinoma cell line...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28315411/extrauterine-choriocarcinoma-in-the-fallopian-tube-following-infertility-treatment-implications-for-the-management-of-early-detected-ectopic-pregnancies
#12
Seung Chik Jwa, Shigeru Kamiyama, Hisako Takayama, Yoshimitsu Tokunaga, Tetsuro Sakumoto, Masahiro Higashi
Extrauterine choriocarcinoma in the fallopian tube is highly rare and is often diagnosed and treated as an ectopic tubal pregnancy. A 34-year old woman who initially became pregnant after infertility treatment using ovulation induction with clomiphene citrate and intrauterine insemination was later diagnosed as having an extrauterine choriocarcinoma in the left fallopian tube. Because of a suspicion of left ectopic tubal pregnancy by ultrasonographic findings and high levels of beta human chorionic gonadotropin (β-hCG; 7054...
March 14, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28306215/primary-mediastinal-and-retroperitoneal-malignant-germ-cell-tumors-in-children-and-adolescents-results-of-the-tgm95-trial-a-study-of-the-french-society-of-pediatric-oncology-soci%C3%A3-t%C3%A3-fran%C3%A3-aise-des-cancers-de-l-enfant
#13
Hélène Sudour-Bonnange, Cécile Faure-Conter, Hélène Martelli, Frederic Hameury, Brice Fresneau, Daniel Orbach, Cécile Vérité
PURPOSE: To examine the clinical presentation, treatment and results in children and adolescents with primary mediastinal (PM) and retroperitoneal (RP) germ cell tumors (GCTs). METHODS: The TGM95 trial for malignant GCTs was conducted in France between 1995 and 2005 to evaluate a strategy adapted to prognostic factors with cisplatin-based chemotherapy and surgical management. We reviewed patients with TGCTs at PM and RP sites. RESULTS: Among 239 patients, there were 16 patients with PM and 5 with RP tumors, which represent 9% of all patients, highlighting the rarity of these extragonadal locations...
March 17, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28296679/primary-cystic-trophoblastic-tumor-of-the-testis-a-study-of-14-cases
#14
Dibson D Gondim, Thomas M Ulbright, Liang Cheng, Muhammad T Idrees
Cystic trophoblastic tumor (CTT) has been described in postchemotherapy retroperitoneal lymph node dissections of patients with testicular germ cell tumors. Prognostically, this lesion is similar to teratoma and no further treatment is required after surgery in the absence of other components. CTT has not, however, been reported in the testis. We identified 14 CTTs in the treated (4) and untreated (9; no information for 1 patient) testes of patients 15 to 43 years old (median, 25) with mixed germ cell tumors...
March 14, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28295835/type-i-interferons-modulate-methotrexate-resistance-in-gestational-trophoblastic-neoplasia
#15
Kevin M Elias, Richard A Harvey, Kathleen T Hasselblatt, Michael J Seckl, Ross S Berkowitz
PROBLEM: Resistance to methotrexate is a leading clinical problem in gestational trophoblastic neoplasia (GTN), but there are limited laboratory models for this condition. METHOD OF STUDY: We created isogenic trophoblastic cell lines resistant to methotrexate and compared these to the parent cell lines using gene expression microarrays and qRT-PCR followed by mechanistic studies using recombinant cytokines, pathway inhibitors, and patient sera. RESULTS: Gene expression microarrays and focused analysis by qRT-PCR revealed methotrexate led to type I interferon upregulation, in particular interferon alpha 2 (IFNA2), and methotrexate resistance was associated with chronic low level increases in type I interferon expression...
March 14, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28292469/down-regulation-of-the-placental-bcrp-abcg2-transporter-in-response-to-hypoxia-signaling
#16
Lissa N Francois, Ludwik Gorczyca, Jianyao Du, Kristin M Bircsak, Elizabeth Yen, Xia Wen, Mei-Juan Tu, Ai-Ming Yu, Nicholas P Illsley, Stacy Zamudio, Lauren M Aleksunes
INTRODUCTION: The BCRP/ABCG2 efflux transporter protects the developing fetus by limiting the transplacental transfer of drugs and chemicals and prevents the apoptosis of trophoblasts. The purpose of this study was to determine whether hypoxia-related signaling alters placental BCRP expression and function in vitro and in human pregnancies. METHODS: Human BeWo choriocarcinoma cells were treated with the hypoxia mimetic, cobalt chloride (CoCl2), or 3% oxygen for 24-48 h...
March 2017: Placenta
https://www.readbyqxmd.com/read/28287945/gestational-trophoblastic-disease-clinical-and-imaging-features
#17
Akram M Shaaban, Maryam Rezvani, Reham R Haroun, Anne M Kennedy, Khaled M Elsayes, Jeffrey D Olpin, Mohamed E Salama, Bryan R Foster, Christine O Menias
Gestational trophoblastic disease (GTD) is a spectrum of both benign and malignant gestational tumors, including hydatidiform mole (complete and partial), invasive mole, choriocarcinoma, placental site trophoblastic tumor, and epithelioid trophoblastic tumor. The latter four entities are referred to as gestational trophoblastic neoplasia (GTN). These conditions are aggressive with a propensity to widely metastasize. GTN can result in significant morbidity and mortality if left untreated. Early diagnosis of GTD is essential for prompt and successful management while preserving fertility...
March 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/28282128/activation-of-peroxisome-proliferator-activated-receptor-gamma-and-disruption-of-progesterone-synthesis-of-2-ethylhexyl-diphenyl-phosphate-in-human-placental-choriocarcinoma-cells-comparison-with-triphenyl-phosphate
#18
Wenxin Hu, Fumei Gao, Hong Zhang, Youhei Hiromori, Shuhei Arakawa, Hisamitsu Nagase, Tsuyoshi Nakanishi, Jianying Hu
2-Ethylhexyl diphenyl phosphate (EHDPP), an organophosphate flame retardant (OPFR), is frequently detected in human blood. In this study, the sensitive dual-luciferase reporter gene assay and molecular docking were used to investigate the activation of EHDPP to human peroxisome proliferator-activated receptor gamma (PPARG). Results show that EHDPP exhibited stronger PPARG activation (EC20: 2.04 μM) than triphenyl phosphate (TPhP) (EC20: 2.78 μM). EHDPP upregulated the gene expression of 3β-hydroxysteroid dehydrogenase type 1 (3β-HSD1) in human placental choriocarcinoma cells in a dose-dependent manner, and the lowest observable effective concentration was 10 μM, lower than that of TPhP (20 μM)...
March 17, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28265226/primary-pulmonary-choriocarcinoma
#19
Ziga Snoj, Igor Kocijancic, Erik Skof
BACKGROUND: The aim of the study was to establish whether there are different clinical entities of primary pulmonary choriocarcinoma (PPC) that deserve different diagnostic approach and the most optimal treatment. PATIENTS AND METHODS: A systematic review with PubMed search was conducted to identify studies that reported cases of PPC. The eligibility criteria were histological diagnosis of pulmonary choriocarcinoma and thorough examination of the reproductive organs to exclude potential primary choriocarcinoma in the gonads...
March 1, 2017: Radiology and Oncology
https://www.readbyqxmd.com/read/28262537/robot-assisted-retroperitoneal-lymph-node-dissection-ra-rplnd-in-the-adolescent-population
#20
A P Glaser, D K Bowen, B W Lindgren, J J Meeks
BACKGROUND: Robot-assisted retroperitoneal lymph node dissection (RA-RPLND) has built on success and techniques of laparoscopic RPLND, with the added benefits of robotic technology. This paper demonstrates use of the da Vinci Xi(®) system for RA-RPLND in two adolescent patients. METHODS: Case #1: A 17-year-old male presented with a left testicular mass and elevated alpha-fetoprotein (AFP) and human chorionic gonadotropin (HCG). Pathology revealed a mixed non-seminomatous germ cell tumor (60% embryonal, 35% yolk sac, 5% choriocarcinoma, + lymphovascular invasion)...
February 17, 2017: Journal of Pediatric Urology
keyword
keyword
74341
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"