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Gender bias

Roberta de Souza Santos, Aaron P Frank, Michael Douglas Nelson, Maurice M Garcia, Biff F Palmer, Deborah J Clegg
Most preclinical and clinical, animal, and human research has been biased with respect to sex and even more so with respect to gender. In fact, little is known about the impact of sex and even less about the influence of gender on overall metabolic processes. The National Institutes of Health has recognized this gap in scientific knowledge and now mandates that studies be conducted in both sexes and to include gender as variables influencing physiological processes such as metabolism. It is therefore critical to understand and appreciate how to incorporate sex and gender in preclinical and clinical research in order to enhance our understanding of the mechanisms by which metabolic processes differ by sex and gender...
2017: Advances in Experimental Medicine and Biology
Vera Schwarzer, Ina Bährend, Tizian Rosenstock, Felix R Dreyer, Peter Vajkoczy, Thomas Picht
BACKGROUND: Navigated transcranial magnetic stimulation (nTMS) is a non-invasive mapping tool to locate functional areas of the brain. While gaining importance in the preoperative planning process in motor eloquent regions, its usefulness for reliably identifying language areas is still being discussed. The aim of this study was to identify biometric factors which might influence and therefore bias the results of repetitive nTMS (rnTMS) over cortex areas relevant for language. METHOD: We included data of 101 patients with language eloquent brain lesions who underwent preoperative rnTMS examination bihemispherically...
December 9, 2017: Acta Neurochirurgica
Alicia DeVault, Monica K Miller
Despite gains in equality for lesbians, gays, and bisexuals (LGB), these couples still face discrimination in adoption scenarios. Guided by the normative window of prejudice and the justification-suppression model, participants read about a suitable or unsuitable couple applying to adopt a child. Participants indicated whether the couple should be allowed to adopt the child and how committed the couple is to being parents. Heterosexuals were perceived as less committed parents compared to LGB parents; sexual orientation was not related to adoption decisions...
December 8, 2017: Journal of Homosexuality
Maria I Davila, Gregory F Lewis, Stephen W Porges
Heart rate variability (HRV) is a reliable indicator of health status and a sensitive index of autonomic stress reactivity. Stress negatively affects physical and psychological wellness by decreasing cardiovascular health and reducing quality of life. Wearable sensors have made it possible to track HRV during daily activity, and recent advances in mobile technology have reduced the cost and difficulty of applying this powerful technique. Although advances have made sensors smaller and lighter, some burden on the subject remains...
2017: Frontiers in Public Health
Rany Abend, Leone de Voogd, Elske Salemink, Reinout W Wiers, Koraly Pérez-Edgar, Amanda Fitzgerald, Lauren K White, Giovanni A Salum, Jie He, Wendy K Silverman, Jeremy W Pettit, Daniel S Pine, Yair Bar-Haim
BACKGROUND: Considerable research links threat-related attention biases to anxiety symptoms in adults, whereas extant findings on threat biases in youth are limited and mixed. Inconsistent findings may arise due to substantial methodological variability and limited sample sizes, emphasizing the need for systematic research on large samples. The aim of this report is to examine the association between threat bias and pediatric anxiety symptoms using standardized measures in a large, international, multi-site youth sample...
December 6, 2017: Depression and Anxiety
Michel Pompeu Barros Oliveira Sá, Artur Freire Soares, Rodrigo Gusmão Albuquerque Miranda, Mayara Lopes Araújo, Alexandre Motta Menezes, Frederico Pires Vasconcelos Silva, Ricardo Carvalho Lima
OBJECTIVE: To compare the safety and efficacy of coronary artery bypass grafting (CABG) with percutaneous coronary intervention (PCI) using drug-eluting stents (DES) in patients with unprotected left main coronary artery (ULMCA) disease. METHODS: MEDLINE, EMBASE, CENTRAL/CCTR, SciELO, LILACS, Google Scholar and reference lists of relevant articles were searched for clinical studies that reported outcomes at 1-year follow-up after PCI with DES and CABG for the treatment of ULMCA stenosis...
September 2017: Brazilian Journal of Cardiovascular Surgery
Alba Casado, Alfonso Palma, Daniela Paolieri
Three different tasks (word repetition, lexical decision, and gender decision) were designed to explore the impact of the sex clues (sex of the speaker, sex of the addressee) and the type of gender (semantic, arbitrary) on the processing of isolated Spanish gendered words. The findings showed that the grammatical gender feature was accessed when no mandatory attentional focus was required. In addition, the results indicated that the participants organize information according to their own sex role, which provides more salience to the words that match in grammatical gender with their own sex role representation, even when the gender assignment is arbitrary...
December 5, 2017: Journal of Psycholinguistic Research
Yong Sung Choi, Wan Jung Kim, Jong Kyu Kim, Do Sun Kim, Doo Han Lee
BACKGROUNDS: In some patients with ulcerative proctitis (UP), skip inflammation is noted in the right side of the colon, but little is known about its clinical course. The aim of this study was to evaluate the clinical course of UP with skip inflammation and the efficacy of topical 5-ASA monotherapy. METHODS: We reviewed the data of 388 patients with an initial diagnosis of UP from January 2005 to October 2015. We matched each UP patient with skip inflammation 1:2 with controls who had UP without skip inflammation; to reduce bias, we matched the controls with the cases by age, gender, and initial disease activity...
December 4, 2017: Journal of Gastroenterology and Hepatology
Jonathana F Antin, Feng Guo, Youjia Fang, Thomas A Dingus, Miguel A Perez, Jonathan M Hankey
INTRODUCTION: This paper evaluated the low mileage bias (LMB) phenomenon for senior drivers using data mined from the Second Strategic Highway Research Program (SHRP 2) Naturalistic Driving Study. Supporters of the LMB construct postulate that it is only those seniors who drive the lowest annual mileage who are primarily responsible for the increased crash rates traditionally attributed to this population in general. METHOD: The current analysis included 802 participants, all aged 65 or older who were involved in 163 property damage and injury crashes, and deemed to be at-fault in 123 (75%) of those instances...
December 2017: Journal of Safety Research
D Ntirampeba, I Neema, L N Kazembe
Background: In disease mapping field, researchers often encounter data from multiple sources. Such data are fraught with challenges such as lack of a representative sample, often incomplete and most of which may have measurement errors, and may be spatially and temporally misaligned. This paper presents a joint model in the effort to deal with the sampling bias and misalignment. Methods: A joint (bivariate) spatial model was applied to estimate HIV prevalence using two sources: 2014 National HIV Sentinel survey (NHSS) among pregnant women aged 15-49 years attending antenatal care (ANC) and the 2013 Namibia Demographic and Health Surveys (NDHS)...
2017: Global health research and policy
Koji Kamagata, Andrew Zalesky, Taku Hatano, Maria Angelique Di Biase, Omar El Samad, Shinji Saiki, Keigo Shimoji, Kanako K Kumamaru, Kouhei Kamiya, Masaaki Hori, Nobutaka Hattori, Shigeki Aoki, Christos Pantelis
Parkinson's disease (PD) is a progressive neurodegenerative disorder that affects extensive regions of the central nervous system. In this work, we evaluated the structural connectome of patients with PD, as mapped by diffusion-weighted MRI tractography and a multi-shell, multi-tissue (MSMT) constrained spherical deconvolution (CSD) method to increase the precision of tractography at tissue interfaces. The connectome was mapped with probabilistic MSMT-CSD in 21 patients with PD and in 21 age- and gender-matched controls...
2018: NeuroImage: Clinical
Elisavet Valanou, Androniki Naska, Anastasia Barbouni, Michael Katsoulis, Eleni Peppa, Pavlos Vidalis, Antonia Trichopoulou
OBJECTIVE: Young children lack basic skills related to recognizing the types of foods they consume and dietary surveys often rely on parents' response. The present study aimed to evaluate how well parents of children aged from 3 months to 10 years perceive images of portions of foods commonly consumed by young children. DESIGN: Pre-weighed, actual food portions (n 2314) were shown to the study participants who were asked to indicate the picture that corresponded to the food in view...
December 4, 2017: Public Health Nutrition
Heledd Hart, Lena Lim, Mitul A Mehta, Antonia Chatzieffraimidou, Charles Curtis, Xiaohui Xu, Gerome Breen, Andrew Simmons, Kah Mirza, Katya Rubia
Childhood maltreatment is associated with attention deficits. We examined the effect of childhood abuse and abuse-by-gene (5-HTTLPR, MAOA, FKBP5) interaction on functional brain connectivity during sustained attention in medication/drug-free adolescents. Functional connectivity was compared, using generalised psychophysiological interaction (gPPI) analysis of functional magnetic resonance imaging (fMRI) data, between 21 age-and gender-matched adolescents exposed to severe childhood abuse and 27 healthy controls, while they performed a parametrically modulated vigilance task requiring target detection with a progressively increasing load of sustained attention...
2017: PloS One
Yao-Kuang Huang, Chieh-Ling Yen, Sz-Iuan Shiu, Shou-Wu Lee, Pi-Yi Chang, Hong-Zen Yeh, Teng-Yu Lee
Targeted therapy is currently the standard treatment for advanced hepatocellular carcinoma (HCC), but an effective treatment after the discontinuation of sorafenib therapy remains uncertain. We aim to investigate the survival benefits of transcatheter arterial chemoembolization (TACE) after stopping sorafenib therapy. We retrospectively analyzed all patients with advanced HCC, who had received palliative TACE after terminating sorafenib therapy, from January 2008 to June 2016. Patients who were in the terminal stage (Child-Pugh class C or performance status 3-4), who received a liver transplantation, or who had received any HCC treatment other than TACE, were excluded...
2017: PloS One
Stacie L Daugherty, Irene V Blair, Edward P Havranek, Anna Furniss, L Miriam Dickinson, Elhum Karimkhani, Deborah S Main, Frederick A Masoudi
BACKGROUND: Physicians' gender bias may contribute to gender disparities in cardiovascular testing. We used the Implicit Association Test to examine the association of implicit gender biases with decisions to use cardiovascular tests. METHODS AND RESULTS: In 2014, cardiologists completed Implicit Association Tests and a clinical vignette with patient gender randomly assigned. The Implicit Association Tests measured implicit gender bias for the characteristics of strength and risk taking...
November 29, 2017: Journal of the American Heart Association
Barend W Florijn, Roel Bijkerk, Eric van der Veer, Anton Jan van Zonneveld
CVD is the primary cause of death among men and women worldwide. Nevertheless, our comprehension of how CVD progresses in women and elicits clinical outcomes is lacking, leading CVD to be under-diagnosed and under-treated in women. A clear example of this differential presentation of CVD pathophysiologies in females is the strikingly higher prevalence of heart failure with preserved ejection fraction (HFpEF). Women with a history of preeclampsia, or those that present co-morbidities such as obesity, hypertension and diabetes mellitus are at increased risk to develop HFpEF...
November 24, 2017: Cardiovascular Research
Ahmad Ameryoun, Hormoz Sanaeinasab, Mohsen Saffari, Harold G Koenig
BACKGROUND: Sedentary lifestyle is growing among children and adolescents that may contribute to problems such as overweight and obesity. Consequently, interventions to improve weight loss in this population are necessary. The aim of this current review was to evaluate the effectiveness of game-based interventions to reduce body mass index (BMI) among children who were overweight or obese. METHODS: All randomized controlled trials with a game-based approach for lowering weight in obese/overweight youths aged 5-18 years old were identified from January 2005 to June 2017 across PubMed, Web of Science, Embase, Scopus, and ScienceDirect...
November 29, 2017: Childhood Obesity
Nidhi Gupta, Marina Heiden, Svend Erik Mathiassen, Andreas Holtermann
Objectives This study aimed to determine the extent to which age, gender, body mass index (BMI) and low-back pain (LBP) influence bias in self-reported sedentary behavior and moderate-to-vigorous physical activity (MVPA) among blue-collar workers. Methods For 2-4 consecutive working days, 147 workers wore an Actigraph accelerometer on the thigh. Proportional time spent sedentary and in MVPA was determined using the Acti4 software. The same variables were also self-reported in a questionnaire. The difference between self-reported and accelerometer-based sedentary time and MVPA was calculated and linearly regressed against age, gender, BMI, and self-reported LBP intensity as main effects, as well as interaction terms combining each of these factors with objectively measured exposure...
November 29, 2017: Scandinavian Journal of Work, Environment & Health
Petra J Havinga, Catharina A Hartman, Ellen Visser, Maaike H Nauta, Brenda W J H Penninx, Lynn Boschloo, Robert A Schoevers
BACKGROUND: Offspring of patients with depressive and/or anxiety disorders are at high risk of developing a similar disorder themselves. Early recognition and treatment may have substantial effects on prognosis. The main aim of this study was to examine the time to initial help-seeking and its determinants in offspring after the first onset of a mood and/or anxiety disorder. METHODS: Data are presented of 215 offspring with a mood and/or anxiety disorder participating in a cohort study with 10 year follow-up...
November 8, 2017: Journal of Affective Disorders
George Wilson, Vincent J Roscigno
The sociological literature on workplace inequality has been relatively clear regarding racial disparities and ongoing vulnerabilities to contemporary structural and employer biases. We still know little, however, about the consequences of age and ageism for minority workers and susceptibilities to downward mobility. Coupling insights regarding race with recent work on employment-based age discrimination, we interrogate in this article African Americans and Whites, aged 55 and older, and the extent to which they experience job loss across time...
January 2018: Social Science Research
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