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Platinum 10-minutes

Akshima Sharma, Anant Mohan, Ashu Seith Bhalla, Mehar Chand Sharma, Sreenivas Vishnubhatla, Chandan J Das, Anil Kumar Pandey, Chandra Sekhar Bal, Chetan D Patel, Punit Sharma, Krishan Kant Agarwal, Rakesh Kumar
PURPOSE: The aim of this study was to prospectively evaluate the role of various quantitative and semiquantitative metabolic parameters derived from dynamic and static baseline F-FDG PET/CT in prediction of overall survival (OS) in non-small cell lung cancer (NSCLC) patients who were planned to undergo platinum-based chemotherapy. METHODS: Sixty patients (51 male and 9 female patients) with biopsy-proven NSCLC and mean age 59.55 ± 10.06 years who were planned to undergo platinum-based chemotherapy were enrolled in the study...
January 2018: Clinical Nuclear Medicine
Valerio Gallotta, Carmine Conte, Maria Teresa Giudice, Camilla Nero, Giuseppe Vizzielli, Salvatore Gueli Alletti, Stefano Cianci, Claudio Lodoli, Andrea Di Giorgio, Agostino Maria De Rose, Anna Fagotti, Giovanni Scambia, Gabriella Ferrandina
STUDY OBJECTIVE: To analyze the feasibility and safety of laparoscopic secondary cytoreductive surgery in a retrospective series of patients with platinum-sensitive recurrent ovarian cancer. DESIGN: Retrospective cohort study (Canadian Task Force classification II-2). SETTING: Catholic University of the Sacred Heart, Rome, Italy. PATIENTS: Between October 2010 and October 2016, 58 patients with recurrent ovarian cancer were selected for a retrospective analysis of data...
November 13, 2017: Journal of Minimally Invasive Gynecology
Narendra Bhadra, Emily Foldes, Tina Vrabec, Kevin L Kilgore, Niloy Bhadra
Application of Kilohertz Frequency Alternating Current (KHFAC) waveforms can result in nerve conduction block that is induced in less than a second. Conduction recovers within seconds when KHFAC is applied for about 5 - 10 minutes. This study investigated the effect of repeated and prolonged application of KHFAC on rat Sciatic nerve with bipolar platinum electrodes. Approach: Varying durations of KHFAC at signal amplitudes for conduction block with intervals of no stimulus were studied. Nerve conduction was monitored by recording peak Gastrocnemius muscle force utilizing stimulation electrodes proximal (PS) and distal (DS) to a blocking electrode...
September 1, 2017: Journal of Neural Engineering
Yi-Cheun Yeh, Elise A Corbin, Steven R Caliari, Liu Ouyang, Sebastián L Vega, Rachel Truitt, Lin Han, Kenneth B Margulies, Jason A Burdick
Mechanics of the extracellular matrix (ECM) play a pivotal role in governing cell behavior, such as cell spreading and differentiation. ECM mechanics have been recapitulated primarily in elastic hydrogels, including with dynamic properties to mimic complex behaviors (e.g., fibrosis); however, these dynamic hydrogels fail to introduce the viscoelastic nature of many tissues. Here, we developed a two-step crosslinking strategy to first form (via platinum-catalyzed crosslinking) networks of polydimethylsiloxane (PDMS) and then to increase PDMS crosslinking (via thiol-ene click reaction) in a temporally-controlled manner...
August 17, 2017: Biomaterials
Dhammapoj Jeerakornpassawat, Prapaporn Suprasert
OBJECTIVE: The aim of this study was to assess intravenous hydrocortisone (HCT) added to standard dexamethasone (DXM) prophylaxis for paclitaxel-associated hypersensitivity reactions (HSRs). METHODS: Paclitaxel naives scheduled for 6 cycles of paclitaxel (plus platinum) were randomized to DXM alone (20 mg intravenously [IV]) versus DXM plus HCT (100 mg IV) as premedication including chlorpheniramine (10 mg IV), diphenhydramine (25 mg orally), and ranitidine (50 mg IV) 30 minutes before infusion...
July 12, 2017: International Journal of Gynecological Cancer
Wesley J Moy, Erica Su, Jason J Chen, Connie Oh, Joe C Jing, Yueqiao Qu, Youmin He, Zhongping Chen, Brian J F Wong
Importance: The classic management of burn scars and other injuries to the skin has largely relied on soft-tissue transfer to resurface damaged tissue with local tissue transfer or skin graft placement. In situ generation of electrochemical reactions using needle electrodes and an application of current may be a new approach to treat scars and skin. Objective: To examine the changes in optical, mechanical, and acoustic impedance properties in porcine skin after electrochemical therapy...
December 1, 2017: JAMA Facial Plastic Surgery
Manasi Sinha, Katherine M McKeon, Savan Parker, Laura G Goergen, Hui Zheng, Firas H El-Khatib, Steven J Russell
BACKGROUND: The physiologic delay in glucose diffusion from the blood to the interstitial fluid and instrumental factors contribute to the delay between changes in plasma glucose (PG) and measurements made by continuous glucose monitors (CGMs). This study compared the duration of this delay for three CGMs. METHODS: A total of 24 healthy adolescent and adult subjects with type 1 diabetes wore three CGM devices simultaneously for 48 hours: Dexcom G4 Platinum, Abbott Navigator, and Medtronic Enlite...
November 2017: Journal of Diabetes Science and Technology
Monika Bozem, Phillip Knapp, Valentin Mirceski, Ewa Slowik, Ivan Bogeski, Reinhard Kappl, Christian Heinemann, Markus Hoth
AIMS: H2O2 is produced by all eukaryotic cells under physiological and pathological conditions. Due to its enormous relevance for cell signaling at low concentrations and anti-pathogenic function at high concentrations, precise quantification of extracellular local H2O2 concentrations ([H2O2]) originating from single cells is required. RESULTS: Using a scanning electrochemical microscope and bare platinum disk ultramicroelectrodes, we established sensitive long term measurements of extracellular [H2O2] kinetics originating from single primary human monocytes ex vivo...
March 17, 2017: Antioxidants & Redox Signaling
Xiang-Min Gu, Zhi-Hui Li, Zhong-Jie He, Zhe-Wei Zhao, Shuang-Qing Liu
BACKGROUND: The optimal time to save a person who has had a sudden cardiac arrest is within the first few minutes of the incident. Early compression and early defibrillation should be performed at this time. Timeliness is the key to successful CPR; as such, Prof. He proposed the "platinum 10 min" system to study early CPR issues. This paper systematically evaluates the success rates of heartbeat restoration within the "platinum 10 min" among patients suffering from sudden cardiac arrest...
2016: Military Medical Research
U Hassan, B Reddy, G Damhorst, O Sonoiki, T Ghonge, C Yang, R Bashir
Complete blood cell counts (CBCs) are one of the most commonly ordered and informative blood tests in hospitals. The results from a CBC, which typically include white blood cell (WBC) counts with differentials, red blood cell (RBC) counts, platelet counts and hemoglobin measurements, can have implications for the diagnosis and screening of hundreds of diseases and treatments. Bulky and expensive hematology analyzers are currently used as a gold standard for acquiring CBCs. For nearly all CBCs performed today, the patient must travel to either a hospital with a large laboratory or to a centralized lab testing facility...
December 2015: Technology
Khine Myint, Yan Li, James Paxton, Mark McKeage
The platinum-based anticancer drug oxaliplatin is important clinically in cancer treatment. However, the role of multidrug resistance-associated protein 2 (MRP2) in controlling oxaliplatin membrane transport, in vivo handling, toxicity and therapeutic responses is unclear. In the current study, preparations of MRP2-expressing and control membrane vesicles, containing inside-out orientated vesicles, were used to directly characterise the membrane transport of oxaliplatin-derived platinum measured by inductively coupled plasma mass spectrometry...
2015: PloS One
Min-Young Lee, Ki Sun Jung, Hae Su Kim, Ji Yun Lee, Sung Hee Lim, Moonjin Kim, Hyun Ae Jung, Sung Min Kim, Jong Mu Sun, Myung-Ju Ahn, Jeeyun Lee, Se Hoon Park, Seong Yoon Yi, In Gyu Hwang, Sang-Cheol Lee, Hee Kyung Ahn, Do Hyoung Lim, Soon Il Lee, Keon Woo Park
AIM: To assess the efficacy and safety of weekly docetaxel plus a fixed-dose rate (FDR) of gemcitabine in metastatic esophageal squamous cell carcinoma (SCC). METHODS: A multi-center, open-label, prospective phase II study was designed. Thirty-three esophageal SCC patients with documented progression after fluoropyrimidine/platinum-based first-line chemotherapy were enrolled and treated with docetaxel 35 mg/m(2) and gemcitabine 1000 mg/m(2) iv at a FDR (10 mg/m(2) per minute) on days 1 and 8...
April 14, 2015: World Journal of Gastroenterology: WJG
Youn Jeong Jang, Ji-Wook Jang, Sun Hee Choi, Jae Young Kim, Ju Hun Kim, Duck Hyun Youn, Won Yong Kim, Suenghoon Han, Jae Sung Lee
Highly efficient tree branch-shaped CuO photocathodes are fabricated using the hybrid microwave annealing process with a silicon susceptor within 10 minutes. The unique hierarchical, one-dimensional structure provides more facile charge transport, larger surface areas, and increased crystallinity and crystal ordering with less defects compared to irregular-shaped CuO prepared by conventional thermal annealing. As a result, the photocathode fabricated with the tree branch-shaped CuO produces an unprecedently high photocurrent density of -4...
May 7, 2015: Nanoscale
Benjamin J Solomon, Tony Mok, Dong-Wan Kim, Yi-Long Wu, Kazuhiko Nakagawa, Tarek Mekhail, Enriqueta Felip, Federico Cappuzzo, Jolanda Paolini, Tiziana Usari, Shrividya Iyer, Arlene Reisman, Keith D Wilner, Jennifer Tursi, Fiona Blackhall
BACKGROUND: The efficacy of the ALK inhibitor crizotinib as compared with standard chemotherapy as first-line treatment for advanced ALK-positive non-small-cell lung cancer (NSCLC) is unknown. METHODS: We conducted an open-label, phase 3 trial comparing crizotinib with chemotherapy in 343 patients with advanced ALK-positive nonsquamous NSCLC who had received no previous systemic treatment for advanced disease. Patients were randomly assigned to receive oral crizotinib at a dose of 250 mg twice daily or to receive intravenous chemotherapy (pemetrexed, 500 mg per square meter of body-surface area, plus either cisplatin, 75 mg per square meter, or carboplatin, target area under the curve of 5 to 6 mg per milliliter per minute) every 3 weeks for up to six cycles...
December 4, 2014: New England Journal of Medicine
Anthony Venbrux, Philippe Gailloud, Martin G Radvany, Leon Rudakov, Maximilian Y Emmert, Andre Plass, Serge D Rousselle, Armando Tellez
OBJECTIVES: Endovascular occlusion of blood vessels represents a key component of interventional therapy. While coils are most commonly used, vessel occlusion is generally not achieved immediately and may necessitate a large number of devices. It has been suggested that endovascular plugs may overcome these limitations; however, immediate and durable occlusion remains a challenge with plugs as well. This study evaluates a newly designed endovascular occlusion system (EOS) METHODS: The EOS combines a nitinol coil with an impermeable membranous cap made of expanded polytetrafluoroethylene...
May 2015: Catheterization and Cardiovascular Interventions
Richard J Finley, John R Mayo, Kyle Grant, Joanne C Clifton, John English, Joyce Leo, Stephen Lam
OBJECTIVES: Growing, small, peripheral, pulmonary nodules in patients at high risk for lung cancer lead to requests for video-assisted thoracoscopic (VATS) resection for pathologic diagnosis. The purpose of this randomized controlled trial was to determine if preoperative localization using percutaneously placed computed tomography (CT)-guided platinum microcoils decreases the need for thoracotomy or VATS anatomic resection (segmentectomy/lobectomy) for diagnosis. METHODS: Patients with undiagnosed nodules of 15 mm or less were randomized to either no localization or preoperative microcoil localization...
January 2015: Journal of Thoracic and Cardiovascular Surgery
Xue-Yan Wu, Xin-En Huang, Jie Cao, Lin Shi, Xia Xu, Zhi-Ying Qian
PURPOSE: To highlight the potential factors that could predict the response rate of patients with metastatic colorectal cancer (mCRC) treated with pemetrexed combined chemotherapy after first- or second-line chemotherapy using the FOLFOX regimen. MATERIALS AND METHODS: Between January 2007 and July 2014, 54 patients diagnosed and pathologically-confirmed with advanced colorectal cancer in Jiangsu Cancer Hospital and Research Institute, were enrolled. They received pemetrexed at a dose of 500mg/m2 by 10 minute infusion on day 1, repeated every 3 weeks...
2014: Asian Pacific Journal of Cancer Prevention: APJCP
Ken Okada, Miyako Akiyoshi, Keiko Ishizaki, Hiroyasu Sato, Takehiro Matsunaga
Five liters of sodium hypochlorite aqueous solution (12 mass%) was poured into 300 L of liquid waste containing ammonium ion of about 1.8 mol/L in a 500 L tank in a plant area; then, two minutes later the solution exploded with a flash on March 30th, 2005. The tank cover, the fluorescent lamp and the air duct were broken by the blast wave. Thus, we have conducted 40 runs of laboratory-scale explosion tests under various conditions (solution concentrations of (NH4)2SO4 and NaClO, temperatures, Pt catalysts, pH, etc...
August 15, 2014: Journal of Hazardous Materials
Edward R Damiano, Katherine McKeon, Firas H El-Khatib, Hui Zheng, David M Nathan, Steven J Russell
The effectiveness and safety of continuous glucose monitors (CGMs) is dependent on their accuracy and reliability. The objective of this study was to compare 3 CGMs in adult and pediatric subjects with type 1 diabetes under closed-loop blood-glucose (BG) control. Twenty-four subjects (12 adults) with type 1 diabetes each participated in one 48-hour closed-loop BG control experiment. Venous plasma glucose (PG) measurements obtained every 15 minutes (4657 values) were paired in time with corresponding CGM glucose (CGMG) measurements obtained from 3 CGMs (FreeStyle Navigator, Abbott Diabetes Care; G4 Platinum, Dexcom; Enlite, Medtronic) worn simultaneously by each subject...
July 2014: Journal of Diabetes Science and Technology
Jill L Worlinsky, Steven Halepas, Christian Brückner
The colorimetric cyanide sensing ability of free base porpholactone, a pyrrole-modified porphyrin in which a porphyrin β,β'-double bond was replaced by a lactone functionality, and its zinc(II), platinum(II), and gallium(III) complexes in aqueous solution are reported. Water-solubility of the parent meso-pentafluorophenyl-derivatized porphyrinoids was assured by PEGylation of the p-aryl positions using a nucleophilic aromatic substitution reaction with thiol-terminated PEG chains. A central metal-dependent sensing mechanism was revealed: While the CN(-) adds to the zinc(II) complex as an axial ligand, resulting in a minor response in its UV-vis spectrum, it undergoes a nucleophilic addition to the lactone moiety in the platinum(II) and gallium(III) complexes, leading to a much more prominent optical response...
June 21, 2014: Organic & Biomolecular Chemistry
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