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Platinum 10-minutes

Xiang-Min Gu, Zhi-Hui Li, Zhong-Jie He, Zhe-Wei Zhao, Shuang-Qing Liu
BACKGROUND: The optimal time to save a person who has had a sudden cardiac arrest is within the first few minutes of the incident. Early compression and early defibrillation should be performed at this time. Timeliness is the key to successful CPR; as such, Prof. He proposed the "platinum 10 min" system to study early CPR issues. This paper systematically evaluates the success rates of heartbeat restoration within the "platinum 10 min" among patients suffering from sudden cardiac arrest...
2016: Military Medical Research
U Hassan, B Reddy, G Damhorst, O Sonoiki, T Ghonge, C Yang, R Bashir
Complete blood cell counts (CBCs) are one of the most commonly ordered and informative blood tests in hospitals. The results from a CBC, which typically include white blood cell (WBC) counts with differentials, red blood cell (RBC) counts, platelet counts and hemoglobin measurements, can have implications for the diagnosis and screening of hundreds of diseases and treatments. Bulky and expensive hematology analyzers are currently used as a gold standard for acquiring CBCs. For nearly all CBCs performed today, the patient must travel to either a hospital with a large laboratory or to a centralized lab testing facility...
December 2015: Technology
Khine Myint, Yan Li, James Paxton, Mark McKeage
The platinum-based anticancer drug oxaliplatin is important clinically in cancer treatment. However, the role of multidrug resistance-associated protein 2 (MRP2) in controlling oxaliplatin membrane transport, in vivo handling, toxicity and therapeutic responses is unclear. In the current study, preparations of MRP2-expressing and control membrane vesicles, containing inside-out orientated vesicles, were used to directly characterise the membrane transport of oxaliplatin-derived platinum measured by inductively coupled plasma mass spectrometry...
2015: PloS One
Min-Young Lee, Ki Sun Jung, Hae Su Kim, Ji Yun Lee, Sung Hee Lim, Moonjin Kim, Hyun Ae Jung, Sung Min Kim, Jong Mu Sun, Myung-Ju Ahn, Jeeyun Lee, Se Hoon Park, Seong Yoon Yi, In Gyu Hwang, Sang-Cheol Lee, Hee Kyung Ahn, Do Hyoung Lim, Soon Il Lee, Keon Woo Park
AIM: To assess the efficacy and safety of weekly docetaxel plus a fixed-dose rate (FDR) of gemcitabine in metastatic esophageal squamous cell carcinoma (SCC). METHODS: A multi-center, open-label, prospective phase II study was designed. Thirty-three esophageal SCC patients with documented progression after fluoropyrimidine/platinum-based first-line chemotherapy were enrolled and treated with docetaxel 35 mg/m(2) and gemcitabine 1000 mg/m(2) iv at a FDR (10 mg/m(2) per minute) on days 1 and 8...
April 14, 2015: World Journal of Gastroenterology: WJG
Youn Jeong Jang, Ji-Wook Jang, Sun Hee Choi, Jae Young Kim, Ju Hun Kim, Duck Hyun Youn, Won Yong Kim, Suenghoon Han, Jae Sung Lee
Highly efficient tree branch-shaped CuO photocathodes are fabricated using the hybrid microwave annealing process with a silicon susceptor within 10 minutes. The unique hierarchical, one-dimensional structure provides more facile charge transport, larger surface areas, and increased crystallinity and crystal ordering with less defects compared to irregular-shaped CuO prepared by conventional thermal annealing. As a result, the photocathode fabricated with the tree branch-shaped CuO produces an unprecedently high photocurrent density of -4...
May 7, 2015: Nanoscale
Benjamin J Solomon, Tony Mok, Dong-Wan Kim, Yi-Long Wu, Kazuhiko Nakagawa, Tarek Mekhail, Enriqueta Felip, Federico Cappuzzo, Jolanda Paolini, Tiziana Usari, Shrividya Iyer, Arlene Reisman, Keith D Wilner, Jennifer Tursi, Fiona Blackhall
BACKGROUND: The efficacy of the ALK inhibitor crizotinib as compared with standard chemotherapy as first-line treatment for advanced ALK-positive non-small-cell lung cancer (NSCLC) is unknown. METHODS: We conducted an open-label, phase 3 trial comparing crizotinib with chemotherapy in 343 patients with advanced ALK-positive nonsquamous NSCLC who had received no previous systemic treatment for advanced disease. Patients were randomly assigned to receive oral crizotinib at a dose of 250 mg twice daily or to receive intravenous chemotherapy (pemetrexed, 500 mg per square meter of body-surface area, plus either cisplatin, 75 mg per square meter, or carboplatin, target area under the curve of 5 to 6 mg per milliliter per minute) every 3 weeks for up to six cycles...
December 4, 2014: New England Journal of Medicine
Anthony Venbrux, Philippe Gailloud, Martin G Radvany, Leon Rudakov, Maximilian Y Emmert, Andre Plass, Serge D Rousselle, Armando Tellez
OBJECTIVES: Endovascular occlusion of blood vessels represents a key component of interventional therapy. While coils are most commonly used, vessel occlusion is generally not achieved immediately and may necessitate a large number of devices. It has been suggested that endovascular plugs may overcome these limitations; however, immediate and durable occlusion remains a challenge with plugs as well. This study evaluates a newly designed endovascular occlusion system (EOS) METHODS: The EOS combines a nitinol coil with an impermeable membranous cap made of expanded polytetrafluoroethylene...
May 2015: Catheterization and Cardiovascular Interventions
Richard J Finley, John R Mayo, Kyle Grant, Joanne C Clifton, John English, Joyce Leo, Stephen Lam
OBJECTIVES: Growing, small, peripheral, pulmonary nodules in patients at high risk for lung cancer lead to requests for video-assisted thoracoscopic (VATS) resection for pathologic diagnosis. The purpose of this randomized controlled trial was to determine if preoperative localization using percutaneously placed computed tomography (CT)-guided platinum microcoils decreases the need for thoracotomy or VATS anatomic resection (segmentectomy/lobectomy) for diagnosis. METHODS: Patients with undiagnosed nodules of 15 mm or less were randomized to either no localization or preoperative microcoil localization...
January 2015: Journal of Thoracic and Cardiovascular Surgery
Xue-Yan Wu, Xin-En Huang, Jie Cao, Lin Shi, Xia Xu, Zhi-Ying Qian
PURPOSE: To highlight the potential factors that could predict the response rate of patients with metastatic colorectal cancer (mCRC) treated with pemetrexed combined chemotherapy after first- or second-line chemotherapy using the FOLFOX regimen. MATERIALS AND METHODS: Between January 2007 and July 2014, 54 patients diagnosed and pathologically-confirmed with advanced colorectal cancer in Jiangsu Cancer Hospital and Research Institute, were enrolled. They received pemetrexed at a dose of 500mg/m2 by 10 minute infusion on day 1, repeated every 3 weeks...
2014: Asian Pacific Journal of Cancer Prevention: APJCP
Ken Okada, Miyako Akiyoshi, Keiko Ishizaki, Hiroyasu Sato, Takehiro Matsunaga
Five liters of sodium hypochlorite aqueous solution (12 mass%) was poured into 300 L of liquid waste containing ammonium ion of about 1.8 mol/L in a 500 L tank in a plant area; then, two minutes later the solution exploded with a flash on March 30th, 2005. The tank cover, the fluorescent lamp and the air duct were broken by the blast wave. Thus, we have conducted 40 runs of laboratory-scale explosion tests under various conditions (solution concentrations of (NH4)2SO4 and NaClO, temperatures, Pt catalysts, pH, etc...
August 15, 2014: Journal of Hazardous Materials
Edward R Damiano, Katherine McKeon, Firas H El-Khatib, Hui Zheng, David M Nathan, Steven J Russell
The effectiveness and safety of continuous glucose monitors (CGMs) is dependent on their accuracy and reliability. The objective of this study was to compare 3 CGMs in adult and pediatric subjects with type 1 diabetes under closed-loop blood-glucose (BG) control. Twenty-four subjects (12 adults) with type 1 diabetes each participated in one 48-hour closed-loop BG control experiment. Venous plasma glucose (PG) measurements obtained every 15 minutes (4657 values) were paired in time with corresponding CGM glucose (CGMG) measurements obtained from 3 CGMs (FreeStyle Navigator, Abbott Diabetes Care; G4 Platinum, Dexcom; Enlite, Medtronic) worn simultaneously by each subject...
July 2014: Journal of Diabetes Science and Technology
Jill L Worlinsky, Steven Halepas, Christian Brückner
The colorimetric cyanide sensing ability of free base porpholactone, a pyrrole-modified porphyrin in which a porphyrin β,β'-double bond was replaced by a lactone functionality, and its zinc(II), platinum(II), and gallium(III) complexes in aqueous solution are reported. Water-solubility of the parent meso-pentafluorophenyl-derivatized porphyrinoids was assured by PEGylation of the p-aryl positions using a nucleophilic aromatic substitution reaction with thiol-terminated PEG chains. A central metal-dependent sensing mechanism was revealed: While the CN(-) adds to the zinc(II) complex as an axial ligand, resulting in a minor response in its UV-vis spectrum, it undergoes a nucleophilic addition to the lactone moiety in the platinum(II) and gallium(III) complexes, leading to a much more prominent optical response...
June 21, 2014: Organic & Biomolecular Chemistry
D Civalleri, M Esposito, F De Cain, F Decian, N Balletto, G Mondini, L Gogioso, M Viale, M O Vannozzi
A pharmacokinetic study was carried out in patients with unresectable colorectal liver metastases who had primarily been included in a phase II trial of intra-arterial cisplatin (DDP) plus intravenous fluorouracil. Ten patients of those accrued for the clinical study underwent the pharmacokinetic investigation upon liver progression of the disease. Four patients were treated with DDP (24 mg/m(2)) through short intra-arterial infusion (baseline study) and 4 patients received intra-arterial hyaluronidase (HY, 100 000IU) 2 minutes before DDP infusion...
August 1996: Clinical Drug Investigation
Belen Sadaba, Anabel del Barrio, Miguel Angel Campanero, Jose Ramon Azanza, Almudena Gomez-Guiu, Jose Maria Lopez-Picazo, Salvador Martin Algarra, Francisco Guillén Grimá, Maria Blanco Prieto, Jose Luis Perez-Gracia, Alfonso Gurpide
BACKGROUND: Palonosetron is a potent second generation 5- hydroxytryptamine-3 selective antagonist which can be administered by either intravenous (IV) or oral routes, but subcutaneous (SC) administration of palonosetron has never been studied, even though it could have useful clinical applications. In this study, we evaluate the bioavailability of SC palonosetron. PATIENTS AND METHODS: Patients treated with platinum-based chemotherapy were randomized to receive SC or IV palonosetron, followed by the alternative route in a crossover manner, during the first two cycles of chemotherapy...
2014: PloS One
Pak-Leung Ho
Instant and sensitive detection of pathogen at ultralow concentrations without time-consuming procedures, such as culture or amplification by PCR, offer obvious advantages. However, there is currently no general and satisfactory assay that could detect bacteria at concentrations of < 100 cfu/mL without pre-enrichment via a culture process. Compared to magnetic beads (1-5 μm in diameter) used in biological separation, magnetic nanoparticles (<10 nm in diameter) promise high performance because of the large surface/volume ratios and easy entry into cells...
February 2014: Pathology
Rohit Lal, Nawel Bourayou, Gunnar Hillerdal, Marianne Nicolson, Anders Vikstrom, Maria Lorenzo, Yulia D'yachkova, Susana Barriga, Carla Visseren-Grul
BACKGROUND: Home-based care in oncology is mainly reserved for patients at the end of life. Regulations regarding home delivery of cytotoxics differ across Europe, with a notable lack of practice guidelines in most countries. This has led to a lack of data addressing the feasibility of home-based administration of cytotoxic chemotherapy. In advanced non-squamous non-small cell lung cancer, pemetrexed is approved as maintenance therapy after first-line chemotherapy. In this setting, patients have the potential to be treated long-term with maintenance therapy, which, in the absence of unacceptable toxicity, is continued until disease progression...
2013: Health and Quality of Life Outcomes
Inge K Herrmann, Andrea Schlegel, Rolf Graf, Christoph M Schumacher, Nico Senn, Melanie Hasler, Sabrina Gschwind, Ann-Marie Hirt, Detlef Günther, Pierre-Alain Clavien, Wendelin J Stark, Beatrice Beck-Schimmer
In a number of clinical conditions such as intoxication, bacteraemia or autoimmune diseases the removal of the disease-causing factor from blood would be the most direct cure. However, physicochemical characteristics of the target compounds limit the applicability of classical filtration and diffusion-based processes. In this work, we present a first in vivo magnetic blood purification rodent animal model and demonstrate its ability to rapidly clear toxins from blood circulation using two model toxins with stable plasma levels (lead (Pb(2+)) and digoxin)...
September 21, 2013: Nanoscale
Xue-Yan Wu, Xin-En Huang, Shan-Xi You, Yan-Yan Lu, Jie Cao, Jin Liu
PURPOSE: To investigate the safety and efficacy of pemetrexed combined with chemotherapy as second or third line in patients with stage IV colorectal cancer (CRC). PATIENTS AND METHODS: This trial was conducted to evaluate the effectiveness and safety of pemetrexed given to patients with recurrent or metastatic colorectal carcinoma who previously received 5-FU-based chemotherapy. All patients were required to have a histological diagnosis of colorectal adenocarcinoma with measurable metastatic disease and prior chemotherapy...
2013: Asian Pacific Journal of Cancer Prevention: APJCP
Suzanne Leijen, Stephan A Veltkamp, Alwin D R Huitema, E van Werkhoven, Jos H Beijnen, Jan H M Schellens
OBJECTIVE: This phase I study of fixed dose rate (FDR) gemcitabine and carboplatin assessed the maximum tolerated dose (MTD), dose-limiting toxicities (DLTs), safety, pharmacokinetic (PK)/pharmacodynamic (PD) profile and preliminary anti-tumor activity in patients with recurrent ovarian cancer (OC). METHODS: Patients with recurrent OC after first line treatment were treated with carboplatin and FDR gemcitabine (infusion speed 10mg/m(2)/min) on days 1, 8 and 15, every 28 days...
September 2013: Gynecologic Oncology
S Muallaoglu, U Disel, H Mertsoylu, A Besen, C Karadeniz, A Taner Sumbul, H Abali, O Ozyilkan
PURPOSE: Treating cancer often involves the use of chemotherapeutic agents. Due to the growing incidence of cancer worldwide and the expanding number of treatment options, it is important to understand the risks of adverse events associated with these treatments. In this study, we monitored the occurrence of acute infusion reactions in an outpatient chemotherapy center from April 2011 to April 2012. METHODS: For patients who developed infusion reactions, the causative drug, the dose and number of treatments received, the onset time of the reaction, the duration of the reaction, blood pressure, pulse, level of oxygen saturation during the reaction, and other symptoms were recorded...
January 2013: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
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