José Lentilhas-Graça, Diogo J Santos, João Afonso, Andreia Monteiro, Andreia G Pinho, Vera M Mendes, Marta S Dias, Eduardo D Gomes, Rui Lima, Luís S Fernandes, Fernando Fernandes-Amorim, Inês M Pereira, Nídia de Sousa, Jorge R Cibrão, Aline M Fernandes, Sofia C Serra, Luís A Rocha, Jonas Campos, Tiffany S Pinho, Susana Monteiro, Bruno Manadas, António J Salgado, Ramiro D Almeida, Nuno A Silva
INTRODUCTION: The inflammatory response after spinal cord injury (SCI) is an important contributor to secondary damage. Infiltrating macrophages can acquire a spectrum of activation states, however, the microenvironment at the SCI site favors macrophage polarization into a pro-inflammatory phenotype, which is one of the reasons why macrophage transplantation has failed. METHODS: In this study, we investigated the therapeutic potential of the macrophage secretome for SCI recovery...
2024: Frontiers in Immunology