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https://www.readbyqxmd.com/read/29656102/activity-in-vitro-and-in-vivo-against-trypanosoma-cruzi-of-a-furofuran-lignan-isolated-from-piper-jericoense
#1
Paola García-Huertas, Francisco Olmo, Manuel Sánchez-Moreno, Jorge Dominguez, Rachid Chahboun, Omar Triana-Chávez
Piperaceae species are abundant in the tropics and are important components of secondary vegetation. Many of these plants have received considerable attention due to their wide range of biological activities. Here, the trypanocidal activity of extracts and fractions with different polarities obtained from Colombian Piper jericoense plant was evaluated. A furofuran lignan, (1S,3aS,4S,6aS)-1-(3',4'-dimethoxyphenyl)-4-(3″,4″-methylendioxyphenyl)hexahydrofuro[3,4-c]furan, (1), was isolated from Colombian Piper jericoense leaves ethyl acetate extract...
April 12, 2018: Experimental Parasitology
https://www.readbyqxmd.com/read/29629832/allelopathic-activity-and-chemical-constituents-of-extracts-from-roots-of-euphorbia-heterophylla-l
#2
Ueveton Pimentel da Silva, Gabriela Milane Furlani, Antônio Jacinto Demuner, Otávio Luis Marques da Silva, Eduardo Vinícius Vieira Varejão
Euphorbia heterophylla L. is regarded as a major weed worldwide. Its high aggressiveness in agricultural environment prompted us to investigate the allelopatic activity and chemical constitution of extracts from roots of this plant. Hexane extract showed low phytotoxic activity. Methanol extract at 2.0 mg mL-1 inhibited 100% of germination, root and shoot growth of the indicator plants Sorghum bicolor and Lactuca sativa. β-sitosterol, stigmasterol, and esters of lupeol, germanicol, taraxasterol, pseudotaraxasterol, α-amyrin and β-amyrin were isolated from the hexane extract and their structures elucidated on the basis of MS and1 H,13 C and DEPT-135 NMR data...
April 9, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29629158/deciphering-the-incognito-role-of-water-in-a-light-driven-proton-coupled-electron-transfer-process
#3
Senthil Kumar Thiyagarajan, Raghupathy Suresh, Vadivel Ramanan, Perumal Ramamurthy
Light induced multisite electron proton transfer in two different phenol (simple and phenol carrying an intramolecularly hydrogen bonded base) pendants on acridinedione dye (ADD) and an NADH analogue was studied by following fluorescence quenching dynamics in an ultrafast timescale. In a simple phenol derivative (ADDOH), photo-excited acridinedione acquires an electron from phenol intramolecularly, coupled with the transfer of a proton to solvent water. But in a phenol carrying hydrogen bonded base (ADDDP), both electron and proton transfer occur completely intramolecularly...
January 28, 2018: Chemical Science
https://www.readbyqxmd.com/read/29593174/cytotoxic-lathyrane-type-diterpenes-from-seeds-of-euphorbia-lathyris
#4
Jia-Xi Wang, Qian Wang, Yong-Qi Zhen, Shuang-Mei Zhao, Feng Gao, Xian-Li Zhou
We isolated two new lathyrane-type diterpenes L27 (1) and L28 (2) along with seven known compounds (3-9) from the seeds of Euphorbia Lathyris. These compounds were identified by nuclear magnetic resonance (NMR), high-resolution electrospray ionisation mass spectrometry (HR-ESI-MS) as well as infrared spectroscopy (IR). Compounds 1 and 2 were assigned NMR spectrums with1 HNMR,13 CNMR, DEPT, COSY, HMQC, HMBC and NOESY.  Stereo configuration of 1 and 2 were confirmed by comprehensive interpretation of their NOE relationship and showed they were first natural lathyrane-type diterpenes possessing α-configuration substitutes at C-3...
March 27, 2018: Chemical & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29587529/laceioside-a-new-cycloartane-saponin-from-astragalus-tephrosioides-boiss-var-lacei-ali-kirchoff
#5
Viqar Uddin Ahmad, Faryal Vali Mohammad, Rasool Bakhsh Tareen
Phytochemical investigation of the aerial parts of Astragalus tephrosioides Boiss. var. lacei (Ali) Kirchoff. (Family Fabaceae) resulted in the isolation of a new cycloartane glycoside laceioside (1). The structure of the previously undescribed compound 1 was established as 16β-acetyloxy-3-O-β-d-glucopyranosyloxy-cycloartan-11α,24ξ, 25-triol. The structure elucidation of compound 1 was based primarily on 1D and 2D-NMR techniques including1 H and13 CNMR spectra, DEPT and by 2D COSY, HSQC and HMBC experiments...
March 27, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29580767/fatty-liver-index-is-associated-to-pulse-wave-velocity-in-healthy-subjects-data-from-the-brisighella-heart-study
#6
Arrigo F G Cicero, Stefano Gitto, Federica Fogacci, Martina Rosticci, Marina Giovannini, Sergio D'Addato, Pietro Andreone, Claudio Borghi
BACKGROUND: Non-Alcoholic Fatty Liver Disease (NAFLD) is associated to increased risk of cardiovascular disease. Our aim was to evaluate association of indexes of fatty liver with arterial stiffness (AS). METHODS: We analyzed data of adult volunteers visited during the last Brisighella survey. We evaluated the Pulse Wave Velocity (PWV) and the following non-invasive indexes of liver steatosis: Fatty Liver Index (FLI), Lipid Accumulation Product (LAP), Hepatic Steatosis Index (HSI)...
March 23, 2018: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/29554236/identification-and-structural-elucidation-of-new-process-impurity-in-testosterone
#7
Vandana Gupte, Umesh Luthra, Neetin Desai
The main objective of this study is identification, isolation and characterization of potential impurity of testosterone. Testosterone was analyzed as per European pharmacopeial method for related substances by high-performance liquid chromatography (HPLC). One new unknown impurity was found along with other pharmacopeial impurities at a level more than 0.10%. This unknown impurity was isolated by preparative HPLC using Symmetry C18 column. The isolated impurity was spiked in sample containing impurities and was found to have the same retention time as that of this unknown impurity...
March 15, 2018: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/29504327/dengue-knowledge-in-indoor-dengue-patients-from-low-socioeconomic-class-aetiology-symptoms-mode-of-transmission-and-prevention
#8
Nadia Shams, Sadia Amjad, Nadeem Yousaf, Waqar Ahmed, Naresh Kumar Seetlani, Shazia Farhat
BACKGROUND: Dengue fever has emerged as an emerging public health issue during last decade bearing significant morbidity and economic burden particularly in third world countries. Current study aims to assess various domains of knowledge of indoor dengue patients.. METHODS: This descriptive crosssectional study was conducted at Medicine dept. Rawal Institute of Health Sciences Islamabad and BBH Rawalpindi over 6 months. One hundred & twenty-five adult indoor confirmed cases of dengue from lower socioeconomic class were included after ethical approval...
January 2018: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/29483213/anti-her2-scfv-directed-extracellular-vesicle-mediated-mrna-based-gene-delivery-inhibits-growth-of-her2-positive-human-breast-tumor-xenografts-by-prodrug-activation
#9
Jing-Hung Wang, Alexis V Forterre, Jingjing Zhao, Daniel O Frimannsson, Alain Delcayre, Travis J Antes, Bradley Efron, Stefanie S Jeffrey, Mark D Pegram, A C Matin
This paper deals with specific targeting of the prodrug/enzyme regimen, CNOB/HChrR6, to treat a serious disease namely HER2+ve human breast cancer with minimal off-target toxicity. HChrR6 is an improved bacterial enzyme that converts CNOB into the cytotoxic drug MCHB. Extracellular vesicles (EVs) were used for mRNA-based HchrR6 gene delivery: EVs may cause minimal immune rejection, and mRNA may be superior to DNA for gene delivery. To confine HChrR6 generation and CNOB activation to the cancer, the EVHB chimeric protein was constructed...
February 26, 2018: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/29480018/antifungal-activity-against-botrytis-cinerea-of-labdane-type-diterpenoids-isolated-from-the-resinous-exudate-of-haplopappus-velutinus-remy-asteraceae
#10
Javier Echeverría, Marcia González-Teuber, Alejandro Urzúa
Two labdane diterpenoids were isolated, from the resinous exudate of Haplopappus velutinus Remy (Asteraceae); the main compound was identified as 7,13-(E)-labdadien-15,18-dioic-acid-18-methyl ester (1) and the minor compound identified as 7-labden-15,18-dioic-acid-18-methyl ester (2). Their structures were obtained using FTIR, MS, HRMS and NMR data: 1D NMR (1 H,13 C and DEPT-135), 2D homonuclear NMR (COSY and NOESY) and heteronuclear NMR (HSQC and HMBC). The trans stereochemistry of the decalin moiety of compounds 1 and 2 was established through NOESY experiments of the reduction product of 1; 7-labden-15,18-diol (1a)...
February 25, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29457748/structural-determination-of-two-new-acacic-acid-type-saponins-from-the-stem-barks-of-albizia-zygia-dc-j-f-macbr
#11
Olivier Placide Noté, Line Made Simo, Joséphine Ngo Mbing, Dominique Guillaume, Christian Dominique Muller, Dieudonné Emmanuel Pegnyemb, Annelise Lobstein
As a continuation of our interest in the study of triterpenoid saponins from Albizia zygia, phytochemical investigation of its stem barks led to the isolation of two new oleanane-type saponins, named zygiaosides C-D (1-2). Their structures were established on the basis of extensive analysis of 1D and 2D NMR (1H-, 13C NMR, DEPT, COSY, TOCSY, ROESY, HSQC and HMBC) experiments, HRESIMS studies, and by chemical evidence as, 3-O-[ β-d-glucopyranosyl-(1→2)-[α-l-arabinopyranosyl-(1→6)]-β-d-glucopyranosyl]-21-O-[(2E,6S)-2,6-dimethyl-6-O-(β-d-quinovopyranosyl) octa-2,7-dienoyl]acacic acid 28-O-α-l-arabinofuranosyl-(1→4)-[β-d-glucopyranosyl-(1→3)]-α-l-rhamnopyranosyl-(1→2)-β-d-glucopyranosyl ester (1) and 3- O-[β-d-glucopyranosyl-(1→2) -[ β-d-fucopyranosyl-(1→6)]-β-d-glucopyranosyl]-21-O-[(2E,6S)-2,6-dimethyl-6-O-(β-D-quinovopyranosyl) octa-2,7-dienoyl]acacic acid 28-O-α-l-arabinofuranosyl-(1→4)-[β-d-glucopyranosyl-(1→3)]-α-l-rhamnopyranosyl-(1→2)-β-d-glucopyranosyl ester (2)...
February 19, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29457747/lebbeckoside-c-a-new-triterpenoid-saponin-from-the-stem-barks-of-albizia-lebbeck-inhibits-the-growth-of-human-glioblastoma-cells
#12
Olivier Placide Noté, Joséphine Ngo Mbing, Marie-Claude Kilhoffer, Dieudonné Emmanuel Pegnyemb, Annelise Lobstein
One new acacic acid-type saponin, named lebbeckoside C (1), was isolated from the stem barks of Albizia lebbeck. Its structure was established on the basis of extensive analysis of 1D and 2D NMR (1 H,13 C NMR, DEPT, COSY, TOCSY, ROESY, HSQC and HMBC) experiments, HRESIMS studies, and by chemical evidence as 3-O-[β-d-xylopyranosyl-(l→2)-β-d-fucopyranosyl-(1→6)-[β-d-glucopyranosyl(1→2)]-β-d-glucopyranosyl]-21-O-{(2E,6S)-6-O-{4-O-[(2E,6S)-2,6-dimethyl-6-O-(β-d-quinovopyranosyl)octa-2,7-dienoyl]-4-O-[(2E,6S)-2,6-dimethyl-6-O-(β-d-quinovopyranosyl)octa-2,7-dienoyl]-β-d-quinovopyranosyl}-2,6-dimethylocta-2,7-dienoyl}acacic acid 28 O-[β-d-quinovopyranosyl-(l→3)-[α-l-arabinofuranosyl-(l→4)]-α-l-rhamnopyranosyl-(l→2)-β-d-glucopyranosyl] ester...
February 19, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29450931/sulfur-radical-transfer-and-coupling-reaction-to-benzoxazine-groups-a-new-reaction-route-for-preparation-of-polymeric-materials-using-elemental-sulfur-as-a-feedstock
#13
Ho-Keng Lin, Ying-Ling Liu
A novel approach to preparing polymeric materials using elemental sulfur as a feedstock through the newly developed sulfur radical transfer and coupling (SRTC) reaction is reported herein. Polybenzoxazines with high sulfur contents are prepared using the SRTC reaction with benzoxazine compounds as the radical acceptors. The reactions between elemental sulfur and benzoxazine rings are analyzed with Fourier transform infrared (FTIR), 1 H NMR, and 13 C DEPT spectroscopies to elucidate the SRTC reaction mechanism...
February 16, 2018: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/29414012/isolation-identification-and-characterization-of-two-novel-process-related-impurities-in-olanzapine
#14
Tao Zhuang, Wen Zhang, Longji Cao, Kai He, Yu Wang, Jing Li, Liang Chen, Bifeng Liu, Guisen Zhang
Olanzapine is a marketed antipsychotic agent for treatment of both positive and negative symptoms of schizophrenia. The chemical synthesis of olanzapine drug substance involved the reaction of thienobenzodiazepine hydrochloride with N-methylpiperazine. During the manufacture of olanzapine, two unknown impurities were present in pilot batches in the range of 0.08-0.22% based upon HPLC analysis. These unknown impurities were enriched from the mother liquor of reaction by preparative HPLC, and characterized by UV, FT-IR, LC-MS/TOF, 1D-NMR (1H, 13C, DEPT), 2D-NMR (1H-1H COSY, HSQC, HMBC, ROESY) and single-crystal X-ray diffraction analysis...
January 31, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29404065/synthesis-isolation-identification-and-characterization-of-new-process-related-impurity-in-isoproterenol-hydrochloride-by-hplc-lc-esi-ms-and-nmr
#15
Neeraj Kumar, Subba Rao Devineni, Prasad Reddy Gajjala, Shailendra Kumar Dubey, Pramod Kumar
One unknown impurity (Imp-II) during the analysis of laboratory batches of isoproterenol hydrochloride was detected in the level ranging from 0.04% to 0.12% by high performance liquid chromatography with UV detection. The unknown impurity structure was proposed as 4-[2-(propan-2-ylamino)ethyl]benzene-1,2-diol (Imp-II) using the liquid chromatography--mass spectrophotometry (LC--MS) analysis. Imp-II was isolated by semi-preparative liquid chromatography from the impurity-enriched reaction crude sample. Its proposed structure was confirmed by nuclear magnetic spectroscopy such as 1H, 13C, DEPT (1D NMR), HSQC (2D NMR) and infrared spectroscopy (IR), and retention time and purity with HPLC followed by the chemical synthesis...
December 2017: Journal of Pharmaceutical Analysis
https://www.readbyqxmd.com/read/29400411/design-synthesis-and-biological-evaluation-of-novel-1-2-diaryl-4-substituted-benzylidene-5-4h-imidazolone-derivatives-as-cytotoxic-agents-and-cox-2-lox-inhibitors
#16
Phoebe F Lamie, John N Philoppes, Lucie Rárová
A new series of 1,2-diaryl-4-substituted-benzylidene-5(4H)-imidazolone derivatives 4a-l was synthesized. Their structures were confirmed by different spectroscopic techniques (IR, 1 H NMR, DEPT-Q NMR, and mass spectroscopy) and elemental analyses. Their cytotoxic activities in vitro were evaluated against breast, ovarian, and liver cancer cell lines and also normal human skin fibroblasts. Cyclooxygenase (COX)-1, COX-2 and lipoxygenase (LOX) inhibitory activities were measured. The synthesized compounds showed selectivity toward COX-2 rather than COX-1, and the IC50 values (0...
February 5, 2018: Archiv der Pharmazie
https://www.readbyqxmd.com/read/29384538/spectroscopic-electrochemical-and-photovoltaic-properties-of-pt-ii-and-pd-ii-complexes-of-a-chelating-1-10-phenanthroline-appended-perylene-diimide
#17
Sebile Işık Büyükekşi, Abdurrahman Şengül, Seda Erdönmez, Ahmet Altındal, Efe Baturhan Orman, Ali Rıza Özkaya
In this study, a bis-chelating bridging perylene diimide ditopic ligand, namely N,N'-di(1,10-phenanthroline)-1,6,7,12-tetrakis-(4-methoxyphenoxy)perylene tetracarboxylic acid diimide (1), was synthesized and characterized. Further reactions of 1 with d8 metal ions such as Pt(ii) and Pd(ii) having preferential square-planar geometry afforded the novel triads [(Cl2)M(ii)-(1)-M(ii)(Cl2)] where M(ii) = Pt(ii) (2), and Pd(ii) (3), respectively. The isolated triads and the key precursor were fully characterized by FT-IR, 1D-NMR (1H NMR and 13C DEPT NMR), 2D-NMR (1H-1H COSY, 1H-13C HSQC, 1H-13C HMBC), MALDI-TOF mass and UV/Vis spectroscopy...
January 31, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29321444/agricultural-aspects-of-radiocontamination-induced-by-the-fukushima-nuclear-accident-a-survey-of-studies-by-the-univ-of-tokyo-agricultural-dept-2011-2016
#18
Tomoko M Nakanishi
Immediately after the Fukushima nuclear power plant accident, a team of 40-50 researchers at the Graduate School of Agricultural and Life Sciences at the University of Tokyo began to analyze the behavior of radioactive materials in the fallout regions. The fallout has remained in situ and become strongly adsorbed within the soil over time. 137 Cs was found to bind strongly to the fine clay, weathered biotite, and organic matter in the soil; therefore, it has not mobilized from mountainous regions, even after heavy rainfall...
2018: Proceedings of the Japan Academy. Series B, Physical and Biological Sciences
https://www.readbyqxmd.com/read/29312737/perforation-of-myocardial-wall-and-great-vessels-after-cardiovascular-interventions-a-5-year-analysis
#19
Zdenek Provaznik, Andreas Holzamer, Daniele Camboni, Leopold Rupprecht, Markus Resch, Sigrid Wittmann, Christof Schmid, Bernhard Floerchinger
Background: Less invasive procedures have replaced open surgical treatment in many cardiovascular disorders. During these interventions, iatrogenic cardiac perforation may ensue, which is a severe complication and requires immediate diagnostic assessment and treatment. Methods: From March 2011 to April 2016, all patients referred to the Dept. of Cardio-thoracic Surgery with the diagnosis of iatrogenic perforation of myocardial wall or great vessels were included into the retrospective study...
December 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29311187/a-shared-aim-for-student-choice-of-family-medicine-an-update-from-adfm-and-family-medicine-for-america-s-health
#20
C Kelly, M A Roett, K McCrory, A Coutinho, N Bhuyan, M Alavi, T Ho, C Stisher, A Bentley, M A Roett, P M Diller, A Davis, M A Roett
No abstract text is available yet for this article.
January 2018: Annals of Family Medicine
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