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https://www.readbyqxmd.com/read/29906557/pro-apoptotic-activity-of-new-triterpenoid-saponins-from-the-roots-of-albizia-adianthifolia-schumach-w-wight
#1
Olivier Placide Noté, Eutrophe Le Doux Kamto, Daniel Djou Toukea, Sarah Ali Aouazou, Joséphine Ngo Mbing, Christian Dominique Muller, Dominique Guillaume, Dieudonné Emmanuel Pegnyemb
As part of our study of the proapoptotic function of saponins from Cameroonian's Albizia genus, phytochemical investigation of the roots of Albizia adianthifolia led to the isolation of three new triterpenoid saponins, named adianthifoliosides GI (13). Their structures were established on the basis of extensive analysis of 1D and 2D NMR (1 H-, 13 C NMR, DEPT, COSY, TOCSY, NOESY, HSQC, HSQC-TOCSY and HMBC) and HRESIMS experiments, and by chemical evidence as 3-O-[β-d-glucopyranosyl-(1 → 2)-β-D-fucopyranosyl-(1 → 6)-β-d-glucopyranosyl]-21-O-{(2E,6S)-2-(hydroxymethyl)-6-methyl-6-O-{4-O-[(2E,6S)-2,6-dimethyl-6-O-(β-D-quinovopyranosyl)octa-2,7-dienoyl]-(β-D-quinovopyranosyl)octa-2,7-dienoyl]}acacic acid-28-O-β-d-xylopyranosyl-(1 → 3)-[5-O-acetyl-α-L-arabinofuranosyl-(1 → 4)]-α-L-rhamnopyranosyl-(1 → 2)-β-d-glucopyranosyl ester (1), 3-O-[β-d-glucopyranosyl-(1 → 2)-β-D-fucopyranosyl-(1 → 6)-β-d-glucopyranosyl]-21-O-{(2E,6S)-2-(hydroxymethyl)-6-methyl-6-O-{4-O-[(2E,6S)-2,6-dimethyl-6-O-(β-D-quinovopyranosyl)octa-2,7-dienoyl]-(β-D-quinovopyranosyl)octa-2,7-dienoyl]}acacic acid 28-O-β-d-xylopyranosyl-(1 → 3)-[α-L-arabinofuranosyl-1 → 4)]-α-L-rhamnopyranosyl-(1 → 2)-β-d-glucopyranosyl ester (2), and 3-O-[β-d-glucopyranosyl-(1 → 2)-β-D-fucopyranosyl-(1 → 6)-β-d-glucopyranosyl]-21-O-{(2E,6S)-2-(hydroxymethyl)-6-methyl-6-O-{4-O-[(2E,6S)-2,6-dimethyl-6-O-(β-D-quinovopyranosyl)octa-2,7-dienoyl]-4-O-[(2E,6S)-2,6-dimethyl-6-O-(β-D-quinovopyranosyl)octa-2,7-dienoyl]-β-D-quinovopyranosyl}-2,6-dimethylocta-2,7-dienoyl}acacic acid 28-O-β-d-xylopyranosyl-(1 → 3)-[α-L-arabinofuranosyl-1 → 4)]-α-L-rhamnopyranosyl-(1 → 2)-β-d-glucopyranosyl ester (3)...
June 12, 2018: Fitoterapia
https://www.readbyqxmd.com/read/29803781/statistical-selection-of-biological-models-for-genome-wide-association-analyses
#2
Wenjian Bi, Guolian Kang, Stanley B Pounds
Genome-wide association studies have discovered many biologically important associations of genes with phenotypes. Typically, genome-wide association analyses formally test the association of each genetic feature (SNP, CNV, etc) with the phenotype of interest and summarize the results with multiplicity-adjusted p-values. However, very small p-values only provide evidence against the null hypothesis of no association without indicating which biological model best explains the observed data. Correctly identifying a specific biological model may improve the scientific interpretation and can be used to more effectively select and design a follow-up validation study...
May 24, 2018: Methods: a Companion to Methods in Enzymology
https://www.readbyqxmd.com/read/29792921/characterization-of-solution-stress-degradation-products-of-aliskiren-and-prediction-of-their-physicochemical-and-admet-properties
#3
Bhoopendra Singh Kushwah, Jugal Gupta, Dilip Kumar Singh, Moolchand Kurmi, Archana Sahu, Saranjit Singh
Forced degradation studies on aliskiren were carried out according to ICH and WHO guidelines. Six degradation products were formed in total in the solution state. Their separation among themselves and from the drug was successfully achieved on a C-18 column utilizing acetonitrile and phosphate buffer (pH 3.0) in the mobile phase, which was run in a gradient mode. To characterize them, a complete mass fragmentation pathway of the drug was first established with the help of MS/TOF and MSn data. This was followed by LC-MS/TOF studies on the degradation products...
May 21, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29779274/-outcome-and-influential-factors-of-speech-therapy-delivered-to-cleft-patients-with-post-operative-velopharyngeal-competence
#4
Chun-Li Guo, Heng Yin, Jing-Tao Li, Cheng-Hao Li, Yang Li, Bing Shi, Qian Zheng
OBJECTIVE: To analyze the training technique, intervention timing, and other related factors involved in the speech therapy delivered to cleft patients with velopharyngeal competence after surgery. METHODS: A retrospective study was conducted on 32 patients who received phonology-articulation speech therapies during 2012 to 2013 in Dept. of Cleft Lip and Palate, West China Hospital of Stomatology, Sichuan University. All patients achieved normal speech one year after therapy...
April 1, 2018: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
https://www.readbyqxmd.com/read/29774878/-etiology-and-risk-factors-for-meningitis-and-or-bacteremia-after-craniotomy-for-patients-with-glioma
#5
Yaning Wang, Yu Wang, Wenbin Ma
To evaluate the incidence and microbiological profile of meningitis and/or bacteremia after craniotomy in patients with glioma and analyze the risk factors relevant to postoperative meningitis.
 Methods: All demographic data, etiological data and clinical data for hospitalized patients who underwent craniotomy in Dept. of Neurosurgery of Peking Union Medical College Hospital between Jan. 2013 to Dec. 2017 were recorded.
 Results: The incidence of post-craniotomy meningitiswas 7.73%, bacteremia was 2.21% and meningitis combined with bacteremia was 1...
April 28, 2018: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/29765717/crystal-structures-of-e-1-naphthaldehyde-oxime-and-e-phenanthrene-9-carbaldehyde-oxime
#6
Jamal Lasri, Katherine Chulvi, Naser Eltaher Eltayeb
The aldoximes C11 H9 NO (I) and C15 H11 NO (II), synthesized in ca 90% yield, by treatment of 1-naphthaldehyde or phenanthrene-9-carbaldehyde, respectively, with hydroxyl-amine hydro-chloride and sodium carbonate, have been characterized by IR, 1 H, 13 C and DEPT-135 NMR spectroscopies, and also by single-crystal X-ray diffraction analysis. The mol-ecules of (I) and (II) are conformationally similar, with the aldoxime substituent groups lying outside the planes of the naphthalene or phenanthrene rings, forming dihedral angles with them of 23...
March 1, 2018: Acta Crystallographica. Section E, Crystallographic Communications
https://www.readbyqxmd.com/read/29715636/new-%C3%AE-glucosidase-inhibitors-from-the-resins-of-boswellia-species-with-structure-glucosidase-activity-and-molecular-docking-studies
#7
Najeeb Ur Rehman, Ajmal Khan, Ahmed Al-Harrasi, Hidayat Hussain, Abdul Wadood, Muhammad Riaz, Zahra Al-Abri
Phytochemical investigation of the oleo-gum resins from Boswellia papyrifera afforded one new triterpene, named 3α-hydroxyurs-5:19-diene (1) together with twelve known compounds including eight triterpenoids (2-9), two diterpenoids (10 and 11) and two straight chain alkanes (12 and 13). Similarly ten more known compounds were isolated from the resin of Boswellia sacra including one triterpene (20) and nine boswellic acids (14-19 and 21-23). Herein the compound 2 was first time reporting from natural source along with complete NMR assignment, while compounds 3-11 are known, but reported for the first time from the resin of B...
April 25, 2018: Bioorganic Chemistry
https://www.readbyqxmd.com/read/29656102/activity-in-vitro-and-in-vivo-against-trypanosoma-cruzi-of-a-furofuran-lignan-isolated-from-piper-jericoense
#8
Paola García-Huertas, Francisco Olmo, Manuel Sánchez-Moreno, Jorge Dominguez, Rachid Chahboun, Omar Triana-Chávez
Piperaceae species are abundant in the tropics and are important components of secondary vegetation. Many of these plants have received considerable attention due to their wide range of biological activities. Here, the trypanocidal activity of extracts and fractions with different polarities obtained from Colombian Piper jericoense plant was evaluated. A furofuran lignan, (1S,3aS,4S,6aS)-1-(3',4'-dimethoxyphenyl)-4-(3″,4″-methylendioxyphenyl)hexahydrofuro[3,4-c]furan, (1), was isolated from Colombian Piper jericoense leaves ethyl acetate extract...
June 2018: Experimental Parasitology
https://www.readbyqxmd.com/read/29629832/allelopathic-activity-and-chemical-constituents-of-extracts-from-roots-of-euphorbia-heterophylla-l
#9
Ueveton Pimentel da Silva, Gabriela Milane Furlani, Antônio Jacinto Demuner, Otávio Luis Marques da Silva, Eduardo Vinícius Vieira Varejão
Euphorbia heterophylla L. is regarded as a major weed worldwide. Its high aggressiveness in agricultural environment prompted us to investigate the allelopatic activity and chemical constitution of extracts from roots of this plant. Hexane extract showed low phytotoxic activity. Methanol extract at 2.0 mg mL-1 inhibited 100% of germination, root and shoot growth of the indicator plants Sorghum bicolor and Lactuca sativa. β-sitosterol, stigmasterol, and esters of lupeol, germanicol, taraxasterol, pseudotaraxasterol, α-amyrin and β-amyrin were isolated from the hexane extract and their structures elucidated on the basis of MS and 1 H, 13 C and DEPT-135 NMR data...
April 9, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29629158/deciphering-the-incognito-role-of-water-in-a-light-driven-proton-coupled-electron-transfer-process
#10
Senthil Kumar Thiyagarajan, Raghupathy Suresh, Vadivel Ramanan, Perumal Ramamurthy
Light induced multisite electron proton transfer in two different phenol (simple and phenol carrying an intramolecularly hydrogen bonded base) pendants on acridinedione dye (ADD) and an NADH analogue was studied by following fluorescence quenching dynamics in an ultrafast timescale. In a simple phenol derivative (ADDOH), photo-excited acridinedione acquires an electron from phenol intramolecularly, coupled with the transfer of a proton to solvent water. But in a phenol carrying hydrogen bonded base (ADDDP), both electron and proton transfer occur completely intramolecularly...
January 28, 2018: Chemical Science
https://www.readbyqxmd.com/read/29593174/cytotoxic-lathyrane-type-diterpenes-from-seeds-of-euphorbia-lathyris
#11
Jia-Xi Wang, Qian Wang, Yong-Qi Zhen, Shuang-Mei Zhao, Feng Gao, Xian-Li Zhou
We isolated two new lathyrane-type diterpenes L27 (1) and L28 (2) along with seven known compounds (3-9) from the seeds of Euphorbia Lathyris. These compounds were identified by nuclear magnetic resonance (NMR), high-resolution electrospray ionisation mass spectrometry (HR-ESI-MS) as well as infrared spectroscopy (IR). Compounds 1 and 2 were assigned NMR spectrums with 1 HNMR, 13 CNMR, DEPT, COSY, HMQC, HMBC and NOESY.  Stereo configuration of 1 and 2 were confirmed by comprehensive interpretation of their NOE relationship and showed they were first natural lathyrane-type diterpenes possessing α-configuration substitutes at C-3...
March 27, 2018: Chemical & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29587529/laceioside-a-new-cycloartane-saponin-from-astragalus-tephrosioides-boiss-var-lacei-ali-kirchoff
#12
Viqar Uddin Ahmad, Faryal Vali Mohammad, Rasool Bakhsh Tareen
Phytochemical investigation of the aerial parts of Astragalus tephrosioides Boiss. var. lacei (Ali) Kirchoff. (Family Fabaceae) resulted in the isolation of a new cycloartane glycoside laceioside (1). The structure of the previously undescribed compound 1 was established as 16β-acetyloxy-3-O-β-d-glucopyranosyloxy-cycloartan-11α,24ξ, 25-triol. The structure elucidation of compound 1 was based primarily on 1D and 2D-NMR techniques including 1 H and 13 CNMR spectra, DEPT and by 2D COSY, HSQC and HMBC experiments...
March 27, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29580767/fatty-liver-index-is-associated-to-pulse-wave-velocity-in-healthy-subjects-data-from-the-brisighella-heart-study
#13
Arrigo F G Cicero, Stefano Gitto, Federica Fogacci, Martina Rosticci, Marina Giovannini, Sergio D'Addato, Pietro Andreone, Claudio Borghi
BACKGROUND: Non-Alcoholic Fatty Liver Disease (NAFLD) is associated to increased risk of cardiovascular disease. Our aim was to evaluate association of indexes of fatty liver with arterial stiffness (AS). METHODS: We analyzed data of adult volunteers visited during the last Brisighella survey. We evaluated the Pulse Wave Velocity (PWV) and the following non-invasive indexes of liver steatosis: Fatty Liver Index (FLI), Lipid Accumulation Product (LAP), Hepatic Steatosis Index (HSI)...
March 23, 2018: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/29554236/identification-and-structural-elucidation-of-new-process-impurity-in-testosterone
#14
Vandana Gupte, Umesh Luthra, Neetin Desai
The main objective of this study is identification, isolation and characterization of potential impurity of testosterone. Testosterone was analyzed as per European pharmacopeial method for related substances by high-performance liquid chromatography (HPLC). One new unknown impurity was found along with other pharmacopeial impurities at a level more than 0.10%. This unknown impurity was isolated by preparative HPLC using Symmetry C18 column. The isolated impurity was spiked in sample containing impurities and was found to have the same retention time as that of this unknown impurity...
March 15, 2018: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/29504327/dengue-knowledge-in-indoor-dengue-patients-from-low-socioeconomic-class-aetiology-symptoms-mode-of-transmission-and-prevention
#15
Nadia Shams, Sadia Amjad, Nadeem Yousaf, Waqar Ahmed, Naresh Kumar Seetlani, Shazia Farhat
BACKGROUND: Dengue fever has emerged as an emerging public health issue during last decade bearing significant morbidity and economic burden particularly in third world countries. Current study aims to assess various domains of knowledge of indoor dengue patients.. METHODS: This descriptive crosssectional study was conducted at Medicine dept. Rawal Institute of Health Sciences Islamabad and BBH Rawalpindi over 6 months. One hundred & twenty-five adult indoor confirmed cases of dengue from lower socioeconomic class were included after ethical approval...
January 2018: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/29483213/anti-her2-scfv-directed-extracellular-vesicle-mediated-mrna-based-gene-delivery-inhibits-growth-of-her2-positive-human-breast-tumor-xenografts-by-prodrug-activation
#16
Jing-Hung Wang, Alexis V Forterre, Jinjing Zhao, Daniel O Frimannsson, Alain Delcayre, Travis J Antes, Bradley Efron, Stefanie S Jeffrey, Mark D Pegram, A C Matin
This paper deals with specific targeting of the prodrug/enzyme regimen, CNOB/HChrR6, to treat a serious disease, namely HER2+ human breast cancer with minimal off-target toxicity. HChrR6 is an improved bacterial enzyme that converts CNOB into the cytotoxic drug MCHB. Extracellular vesicles (EV) were used for mRNA-based H chrR6 gene delivery: EVs may cause minimal immune rejection, and mRNA may be superior to DNA for gene delivery. To confine HChrR6 generation and CNOB activation to the cancer, the EVHB chimeric protein was constructed...
May 2018: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/29480018/antifungal-activity-against-botrytis-cinerea-of-labdane-type-diterpenoids-isolated-from-the-resinous-exudate-of-haplopappus-velutinus-remy-asteraceae
#17
Javier Echeverría, Marcia González-Teuber, Alejandro Urzúa
Two labdane diterpenoids were isolated, from the resinous exudate of Haplopappus velutinus Remy (Asteraceae); the main compound was identified as 7,13-(E)-labdadien-15,18-dioic-acid-18-methyl ester (1) and the minor compound identified as 7-labden-15,18-dioic-acid-18-methyl ester (2). Their structures were obtained using FTIR, MS, HRMS and NMR data: 1D NMR (1 H, 13 C and DEPT-135), 2D homonuclear NMR (COSY and NOESY) and heteronuclear NMR (HSQC and HMBC). The trans stereochemistry of the decalin moiety of compounds 1 and 2 was established through NOESY experiments of the reduction product of 1; 7-labden-15,18-diol (1a)...
February 25, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29457748/structural-determination-of-two-new-acacic-acid-type-saponins-from-the-stem-barks-of-albizia-zygia-dc-j-f-macbr
#18
Olivier Placide Noté, Line Made Simo, Joséphine Ngo Mbing, Dominique Guillaume, Christian Dominique Muller, Dieudonné Emmanuel Pegnyemb, Annelise Lobstein
As a continuation of our interest in the study of triterpenoid saponins from Albizia zygia, phytochemical investigation of its stem barks led to the isolation of two new oleanane-type saponins, named zygiaosides C-D (1-2). Their structures were established on the basis of extensive analysis of 1D and 2D NMR (1H-, 13C NMR, DEPT, COSY, TOCSY, ROESY, HSQC and HMBC) experiments, HRESIMS studies, and by chemical evidence as, 3-O-[ β-d-glucopyranosyl-(1→2)-[α-l-arabinopyranosyl-(1→6)]-β-d-glucopyranosyl]-21-O-[(2E,6S)-2,6-dimethyl-6-O-(β-d-quinovopyranosyl) octa-2,7-dienoyl]acacic acid 28-O-α-l-arabinofuranosyl-(1→4)-[β-d-glucopyranosyl-(1→3)]-α-l-rhamnopyranosyl-(1→2)-β-d-glucopyranosyl ester (1) and 3- O-[β-d-glucopyranosyl-(1→2) -[ β-d-fucopyranosyl-(1→6)]-β-d-glucopyranosyl]-21-O-[(2E,6S)-2,6-dimethyl-6-O-(β-D-quinovopyranosyl) octa-2,7-dienoyl]acacic acid 28-O-α-l-arabinofuranosyl-(1→4)-[β-d-glucopyranosyl-(1→3)]-α-l-rhamnopyranosyl-(1→2)-β-d-glucopyranosyl ester (2)...
February 19, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29457747/lebbeckoside-c-a-new-triterpenoid-saponin-from-the-stem-barks-of-albizia-lebbeck-inhibits-the-growth-of-human-glioblastoma-cells
#19
Olivier Placide Noté, Joséphine Ngo Mbing, Marie-Claude Kilhoffer, Dieudonné Emmanuel Pegnyemb, Annelise Lobstein
One new acacic acid-type saponin, named lebbeckoside C (1), was isolated from the stem barks of Albizia lebbeck. Its structure was established on the basis of extensive analysis of 1D and 2D NMR (1 H, 13 C NMR, DEPT, COSY, TOCSY, ROESY, HSQC and HMBC) experiments, HRESIMS studies, and by chemical evidence as 3-O-[β-d-xylopyranosyl-(l→2)-β-d-fucopyranosyl-(1→6)-[β-d-glucopyranosyl(1→2)]-β-d-glucopyranosyl]-21-O-{(2E,6S)-6-O-{4-O-[(2E,6S)-2,6-dimethyl-6-O-(β-d-quinovopyranosyl)octa-2,7-dienoyl]-4-O-[(2E,6S)-2,6-dimethyl-6-O-(β-d-quinovopyranosyl)octa-2,7-dienoyl]-β-d-quinovopyranosyl}-2,6-dimethylocta-2,7-dienoyl}acacic acid 28 O-[β-d-quinovopyranosyl-(l→3)-[α-l-arabinofuranosyl-(l→4)]-α-l-rhamnopyranosyl-(l→2)-β-d-glucopyranosyl] ester...
February 19, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29450931/sulfur-radical-transfer-and-coupling-reaction-to-benzoxazine-groups-a-new-reaction-route-for-preparation-of-polymeric-materials-using-elemental-sulfur-as-a-feedstock
#20
Ho-Keng Lin, Ying-Ling Liu
A novel approach to preparing polymeric materials using elemental sulfur as a feedstock through the newly developed sulfur radical transfer and coupling (SRTC) reaction is reported herein. Polybenzoxazines with high sulfur contents are prepared using the SRTC reaction with benzoxazine compounds as the radical acceptors. The reactions between elemental sulfur and benzoxazine rings are analyzed with Fourier transform infrared (FTIR), 1 H NMR, and 13 C DEPT spectroscopies to elucidate the SRTC reaction mechanism...
April 2018: Macromolecular Rapid Communications
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