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https://www.readbyqxmd.com/read/28191810/gist-institutional-experience-at-srms-ims-india
#1
Shubhanshu Gupta, Keshri Amit, Ashish Gupta, Tanu Argawal
Gastro-Intestinal Stromal Tumors (GIST) is a malignant, non-epithelial, mesenchymal tumor of the digestive tract that is not uncommon in clinical practice nowadays; diagnosis being based upon immuno-histo-chemical analysis of the resected or biopsied (FNAC) specimen. Abdominal lump with or without intra-luminal bleed is a common mode of presentation. Early diagnosis and appropriate management with surgery and/or Imatinib therapy improves recurrence free survival and may impact overall survival. We present here our institutional experience of four patients, admitted in Onco-Surgery Dept...
September 2016: Gulf Journal of Oncology
https://www.readbyqxmd.com/read/28183048/potential-impurities-of-anxiolytic-drug-clobazam-identification-synthesis-and-characterization-using-hplc-lc-esi-ms-n-and-nmr
#2
Neeraj Kumar, Subba Rao Devineni, Shailendra Kumar Dubey, Pramod Kumar
During the optimization of process, eight impurities (CLB Imp-A to CLB Imp-H) were detected in few of the laboratory batches of clobazam, used as anxiolytic agent, in the range of 0.02-0.12% using gradient HPLC method with UV detection. On the basis of co-spiking analysis, six impurities (CLB Imp-A to -F) enumerated by European Pharmacopoeia, however, not reported in the earlier literature, have been harmonized and found to be two impurities are completely unknown (CLB Imp-G and -H). These two new impurities structures were presumed based on LC-ESI/MS(n) study as 8-chloro-1-methyl-5-phenyl-1,5-dihydro-3H-1,5-benzodiazepine-2,4-dione (CLB Imp-G) and 5-chloro-1-methyl-3-phenyl-1H-benzo[d]imidazol-2(3H)-one (CLB Imp-H)...
January 29, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28152388/spectral-characterization-and-antibacterial-activity-of-an-isolated-compound-from-memecylon-edule-leaves
#3
R Srinivasan, D Natarajan, M S Shivakumar
Memecylon edule Roxb. (Melastamataceae family) is a small evergreen tree reported as having ethnobotanical and pharmacological properties. The present study was aimed to investigate the spectral characterization and antibacterial activity of isolated pure compound (3β-hydroxyurs-12-en-28-oic acid (ursolic acid)) from Memecylon edule leaves by performing bioassay guided isolation method. The structure derivation of isolated compound was done by different spectral studies like UV, FT-IR, LC-MS, CHNS analysis, 1D ((1)H, (13)C and DEPT-135) and 2D-NMR (HSQC and HMBC), respectively...
January 21, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28146121/a-novel-diterpene-glycoside-with-nine-glucose-units-from-stevia-rebaudiana-bertoni
#4
Indra Prakash, Gil Ma, Cynthia Bunders, Romila D Charan, Catherine Ramirez, Krishna P Devkota, Tara M Snyder
Following our interest in new diterpene glycosides with better taste profiles than that of Rebaudioside M, we have recently isolated and characterized Rebaudioside IX-a novel steviol glycoside-from a commercially-supplied extract of Stevia rebaudiana Bertoni. This molecule contains a hexasaccharide group attached at C-13 of the central diterpene core, and contains three additional glucose units when compared with Rebaudioside M. Here we report the complete structure elucidation-based on extensive Nuclear Magnetic Resonance (NMR) analysis (1H, 13C, Correlation Spectroscopy (COSY), Heteronuclear Single Quantum Coherence-Distortionless Enhancement Polarization Transfer (HSQC-DEPT), Heteronuclear Multiple Bond Correlation (HMBC), 1D Total Correlation Spectroscopy (TOCSY), Nuclear Overhauser Effect Spectroscopy (NOESY)) and mass spectral data-of this novel diterpene glycoside with nine sugar moieties and containing a relatively rare 16 α-linked glycoside...
January 31, 2017: Biomolecules
https://www.readbyqxmd.com/read/28117890/costs-of-food-safety-investments-in-the-meat-and-poultry-slaughter-industries
#5
REVIEW
Catherine L Viator, Mary K Muth, Jenna E Brophy, Gary Noyes
To develop regulations efficiently, federal agencies need to know the costs of implementing various regulatory alternatives. As the regulatory agency responsible for the safety of meat and poultry products, the U.S. Dept. of Agriculture's Food Safety and Inspection Service is interested in the costs borne by meat and poultry establishments. This study estimated the costs of developing, validating, and reassessing hazard analysis and critical control points (HACCP), sanitary standard operating procedures (SSOP), and sampling plans; food safety training for new employees; antimicrobial equipment and solutions; sanitizing equipment; third-party audits; and microbial tests...
January 24, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/28108024/isolation-of-isoflavones-from-iris-kashmiriana-baker-as-potential-anti-proliferative-agents-targeting-nf-kappab
#6
Afroze Alam, Varun Jaiswal, Sohail Akhtar, B S Jayashree, K L Dhar
Cancer is possibly one of the most devastating and complex disease and therefore involves chemotherapy as one of the frontline strategies in its therapy. However, expected toxicity and resistance with chemotherapeutic agents encourage us to use the plant derived natural chemotherapeutic sources at the clinical stage of cancer therapy. In view of this strategy, herein new glycosides and isoflavonoids were isolated from Iris kashmiriana Baker and subjected to structure elucidation followed by their biological evaluation...
January 17, 2017: Phytochemistry
https://www.readbyqxmd.com/read/28095825/no-regrets-young-adult-patients-in-psychiatry-report-positive-reactions-to-biobank-participation
#7
Janet L Cunningham, Manuel Zanzi, Mimmie Willebrand, Lisa Ekselius, Mia Ramklint
BACKGROUND: Research in vulnerable individuals must insure voluntariness and minimize negative reactions caused by participation. This study aimed to describe consent and completion rate in young psychiatric patients in relation to study components, degree of disability and to compare response to research participation in patients and controls. METHODS: Between 2012 and 2015, 463 patients with psychiatric disorders between the ages of 18-25 from the Dept. of General Psychiatry at Uppsala University Hospital and 105 controls were recruited to donate data and samples to a biobank...
January 17, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28024540/extraction-and-characterization-of-pectins-from-primary-cell-walls-of-edible-a%C3%A3-a%C3%A3-euterpe-oleraceae-berries-fruits-of-a-monocotyledon-palm
#8
Thaisa Moro Cantu-Jungles, Marcello Iacomini, Thales R Cipriani, Lucimara M C Cordeiro
Açaí berries (Euterpe oleracea) are greatly consumed in Brazil and exported to other countries as a nutritional supplement, due to health benefits attributed to its consumption. However, the complete chemical structure of bioactive polysaccharides was not fully elucidated yet. In this work, we characterize pectic polysaccharides from açaí berries through monosaccharide composition, HPSEC, methylation and (13)C and (1)H/(13)C HSQC-DEPT-NMR analyses. A highly methoxylated homogalacturonan with a DM of 88% and Mw of 22kDa together with small amounts of a mannoglucan were found...
February 20, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/27988702/nine-new-i-trechisibus-i-species-from-peru-and-argentina-coleoptera-carabidae-trechinae
#9
Gianni Allegro, Pier Mauro Giachino
Nine new Trechisibus species are described, four from Central Peru (T. huascarani n. sp. and T. recuayi n. sp. from Dept. Ancash, T. curtii n. sp. and T. lemairei n. sp. from Dept. Huanuco) and five from Patagonian Argentina, Province of Rio Negro (T. brevis n. sp., T. longipenis n. sp., T. parvulus n. sp., T. sciakyi n. sp., T. striatus n. sp.).
November 15, 2016: Zootaxa
https://www.readbyqxmd.com/read/27973724/investigations-on-antioxidant-antiproliferative-and-cox-2-inhibitory-potential-of-alkaloids-from-anthocephalus-cadamba-roxb-miq-leaves
#10
Madhu Chandel, Manish Kumar, Upendra Sharma, Bikram Singh, Satwinderjeet Kaur
In the present study, an ayurvedic medicinal plant, Anthocephalus cadamba (Roxb.) Miq. commonly known as "Kadamb" was explored for its potential against oxidative stress and cancer. The fractions namely AC-4 and ACALK (alkaloid rich fraction) were isolated from Anthocephalus cadamba leaves by employing two different isolation methods and evaluated for their in vitro antioxidant and antiproliferative activity. The isolated molecule, AC-4 was characterized tentatively as dihydrocadambine by using various spectroscopic techniques such as ESI-QTOF-MS, (1) H-NMR, (13) C-NMR, DEPT, COSY, HMQC and HMBC...
December 14, 2016: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/27823880/amaryllidaceae-alkaloids-with-new-framework-types-from-zephyranthes-candida-as-potent-acetylcholinesterase-inhibitors
#11
Guanqun Zhan, Junjun Liu, Junfei Zhou, Bin Sun, Haji Akber Aisa, Guangmin Yao
Three new Amaryllidaceae alkaloids, named zephycandidines I-III (1-3), were isolated from Zephyranthes candida. The structures of 1-3 were elucidated by spectroscopic analyses including HRESIMS, (1)H NMR, (13)C NMR, DEPT, HSQC, (1)H-(1)H COSY, HMBC, ROESY, and electronic circular dichroism (ECD), as well as ECD calculation. The absolute configuration of 1 was finally established by single crystal X-ray diffraction using Cu Kα radiation. Zephycandidines I (1) and III (3) with new framework types represent the first example of 7-phenyl-hexahydroindole and 5,2'-dimethyl-biphenyl-2-ylamine alkaloids, respectively, and their plausible biosynthetic pathway are proposed...
October 27, 2016: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27766934/cc-promise-effectively-integrates-two-forms-of-molecular-data-with-multiple-biologically-related-endpoints
#12
Xueyuan Cao, Kristine R Crews, James Downing, Jatinder Lamba, Stanley B Pounds
BACKGROUND: As new technologies allow investigators to collect multiple forms of molecular data (genomic, epigenomic, transcriptomic, etc) and multiple endpoints on a clinical trial cohort, it will become necessary to effectively integrate all these data in a way that reliably identifies biologically important genes. METHODS: We introduce CC-PROMISE as an integrated data analysis method that combines components of canonical correlation (CC) and projection onto the most interesting evidence (PROMISE)...
October 6, 2016: BMC Bioinformatics
https://www.readbyqxmd.com/read/27765569/%C3%AE-1%C3%A2-3-1%C3%A2-6-d-glucans-produced-by-diaporthe-sp-endophytes-purification-chemical-characterization-and-antiproliferative-activity-against-mcf-7-and-hepg2-c3a-cells
#13
Ravely Casarotti Orlandelli, Maria de Lourdes Corradi da Silva, Ana Flora Dalberto Vasconcelos, Igor Vivian Almeida, Veronica Elisa Pimenta Vicentini, Alicia Prieto, Maria Dolores Diaz Hernandez, João Lúcio Azevedo, João Alencar Pamphile
This study reports the characterization and antiproliferative activity of exopolysaccharides (EPS) produced by submerged cultures of the endophytes Diaporthe sp. JF766998 and Diaporthe sp. JF767007 isolated from the medicinal plant Piper hispidum Sw. Both strains secreted a crude EPS that, upon size exclusion chromatography, showed to contain a heteropolysaccharide (galactose, glucose and mannose) and a high-molecular weight glucan. Data from methylation analysis, FTIR and NMR spectroscopy ((1)H, COSY, TOCSY and HSQC-DEPT) indicated that the purified glucan consisted of a main chain of glucopyranosyl β-(1→3) linkages substituted at O-6 by glucosyl residues...
January 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27762065/32-years-of-experience-with-co2-laser-assisted-treatment-for-zenker-s-diverticulum-an-update-of-227-patients-treated-in-kiel
#14
M Hoffmann, A Fazel, K-G Mews, P Ambrosch
OBJECTIVES: To underline the value of the microendoscopic CO2 -LASER-assisted treatment (MEDCO2 ) for Zenker's diverticulum by investigating a large patient cohort treated in a single medical centre. DESIGN: Retrospective cohort study of consecutive patients. SETTING: Department of Otorhinolaryngology, Head and Neck Surgery, Christian-Albrechts-University Kiel, Germany. PARTICIPANTS: A total of 227 patients with Zenker's diverticulum were treated by MEDCO2 , and the results were compared with those reported in the literature for the open transcervical approach (OTA) and the endoscopic staple-assisted oesophagodiverticulostomy (ESED)...
October 19, 2016: Clinical Otolaryngology
https://www.readbyqxmd.com/read/27761694/chodatiionosides-a-and-b-two-new-megastigmane-glycosides-from-chorisia-chodatii-leaves
#15
Mamdouh Nabil Samy, John Refaat Fahim, Sachiko Sugimoto, Hideaki Otsuka, Katsuyoshi Matsunami, Mohamed Salah Kamel
Phytochemical investigation of Chorisia chodatii Hassl. leaves led to the isolation of an unusual rearranged megastigmane glycoside; chodatiionoside A (1) and another new megastigmane glycoside; chodatiionoside B (2), together with three known megastigmane glycosides (3-5) and one known flavonoid glycoside (6). Their structures were elucidated by spectroscopic methods including 1D and 2D NMR experiments ((1)H, (13)C, DEPT, COSY, HSQC and HMBC) in combination with HR-ESI-MS, CD and modified Mosher's method. As a result, chodatiionoside A has been elucidated as a first example of an unusual rearranged form of megastigmane...
January 2017: Journal of Natural Medicines
https://www.readbyqxmd.com/read/27730681/novel-compounds-with-new-anti-ulcergenic-activity-from-convolvulus-pilosellifolius-using-bio-guided-fractionation
#16
Amani S Awaad, Asmaa Al-Refaie, Reham El-Meligy, Mohamed Zain, Hesham Soliman, Mohamed S Marzoke, Nabil El-Sayed
Oral administration of the total alcohol extract of Convolvulus pilosellifolius Desr. (250 and 500 md/kg) showed potent anti-ulcerogenic activity in absolute ethanol-induced ulcer model in rats; it showed percent protection of control ulcer by 69.2 and 84.6%, respectively, while standard ranitidine (100 mg/kg) exhibited 46.2%. Bio-guided work leads to isolation of two novel compounds (1 and 2), which were identified through (1) H, (13) C NMR, HMPC, HMQC and DEPT as: methyl 2-(hydroxymethyl) octanoate, named as amanitate, and 16-amino-9,13-dimethyl-17-(prop-1-en-2-yl)-hexadecahydro-1H-cyclopenta[a] phenanthren-3-ol, named as asmatol...
December 2016: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/27724978/the-copenhagen-triage-algorithm-a-randomized-controlled-trial
#17
Rasmus Bo Hasselbalch, Louis Lind Plesner, Mia Pries-Heje, Lisbet Ravn, Morten Lind, Rasmus Greibe, Birgitte Nybo Jensen, Lars S Rasmussen, Kasper Iversen
BACKGROUND: Crowding in the emergency department (ED) is a well-known problem resulting in an increased risk of adverse outcomes. Effective triage might counteract this problem by identifying the sickest patients and ensuring early treatment. In the last two decades, systematic triage has become the standard in ED's worldwide. However, triage models are also time consuming, supported by limited evidence and could potentially be of more harm than benefit. The aim of this study is to develop a quicker triage model using data from a large cohort of unselected ED patients and evaluate if this new model is non-inferior to an existing triage model in a prospective randomized trial...
October 10, 2016: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
https://www.readbyqxmd.com/read/27637313/6-acetamidoflavone-obtained-by-microbiological-and-chemical-methods-and-its-antioxidant-activity
#18
Monika Stompor
The aim of this research was to select microbial strains capable of transforming flavonoid compounds containing an amino group. 6-Aminoflavone (1) was used as a model compound. Biotransformation of 1 by the cultures of Rhodococcus sp. DSM 364 and Gordonia sp. DSM 44456 bacteria led to 6-acetamidoflavone (2) with the isolated yields in 86% and 93%, respectively. The structure of the product was determined on the basis of spectroscopic data, including NMR spectra ((1)H, (13)C, (1)H-(1)H, (1)H-(13)C, and DEPT 135°), a UV and IR spectrum and HR ESI-MS analysis...
November 10, 2016: Journal of Biotechnology
https://www.readbyqxmd.com/read/27580094/front-matter-and-contents
#19
(no author information available yet)
The present study is primarily aimed at an audience of evolutionary biologists in the broad sense for Parts 1-3, as well as at scientists from other professional disciplines looking for new approaches to explore phenomena in nature. However, the content is in general not written as technical text or filled with equations that make it utterly incomprehensible for 'normal' people, although they would have to skip strictly professional biochemical and biological terms that are a constituent part of the evidence in a scientific sense...
2016: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/27548143/potential-of-pseudoshikonin-i-isolated-from-lithospermi-radix-as-inhibitors-of-mmps-in-il-1%C3%AE-induced-sw1353-cells
#20
Dae Young Lee, Soo-Im Choi, Se Hee Han, Ye-Joo Lee, Jong-Gil Choi, Young-Seob Lee, Je Hun Choi, Seung-Eun Lee, Geum-Soog Kim
Pseudoshikonin I, the new bioactive constituent of Lithospermi radix, was isolated from this methanol extract by employing reverse-phase medium-pressure liquid chromatography (MPLC) using acetonitrile/water solvent system as eluents. The chemical structure was determined based on spectroscopic techniques, including 1D NMR (¹H, (13)C, DEPT), 2D NMR (gCOSY, gHMBC, gHMQC), and QTOF/MS data. In this study, we demonstrated the effect of pseudoshikonin I on matrix-metalloproteinase (MMPs) activation and expression in interleukin (IL)-1β-induced SW1353 chondrosarcoma cells...
August 18, 2016: International Journal of Molecular Sciences
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