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Thaisa Moro Cantu-Jungles, Marcello Iacomini, Thales R Cipriani, Lucimara M C Cordeiro
Açaí berries (Euterpe oleracea) are greatly consumed in Brazil and exported to other countries as a nutritional supplement, due to health benefits attributed to its consumption. However, the complete chemical structure of bioactive polysaccharides was not fully elucidated yet. In this work, we characterize pectic polysaccharides from açaí berries through monosaccharide composition, HPSEC, methylation and (13)C and (1)H/(13)C HSQC-DEPT-NMR analyses. A highly methoxylated homogalacturonan with a DM of 88% and Mw of 22kDa together with small amounts of a mannoglucan were found...
February 20, 2017: Carbohydrate Polymers
Gianni Allegro, Pier Mauro Giachino
Nine new Trechisibus species are described, four from Central Peru (T. huascarani n. sp. and T. recuayi n. sp. from Dept. Ancash, T. curtii n. sp. and T. lemairei n. sp. from Dept. Huanuco) and five from Patagonian Argentina, Province of Rio Negro (T. brevis n. sp., T. longipenis n. sp., T. parvulus n. sp., T. sciakyi n. sp., T. striatus n. sp.).
November 15, 2016: Zootaxa
Madhu Chandel, Manish Kumar, Upendra Sharma, Bikram Singh, Satwinderjeet Kaur
In the present study, an ayurvedic medicinal plant, Anthocephalus cadamba (Roxb.) Miq. commonly known as "Kadamb" was explored for its potential against oxidative stress and cancer. The fractions namely AC-4 and ACALK (alkaloid rich fraction) were isolated from Anthocephalus cadamba leaves by employing two different isolation methods and evaluated for their in vitro antioxidant and antiproliferative activity. The isolated molecule, AC-4 was characterized tentatively as dihydrocadambine by using various spectroscopic techniques such as ESI-QTOF-MS, (1) H-NMR, (13) C-NMR, DEPT, COSY, HMQC and HMBC...
December 14, 2016: Chemistry & Biodiversity
Guanqun Zhan, Junjun Liu, Junfei Zhou, Bin Sun, Haji Akber Aisa, Guangmin Yao
Three new Amaryllidaceae alkaloids, named zephycandidines I-III (1-3), were isolated from Zephyranthes candida. The structures of 1-3 were elucidated by spectroscopic analyses including HRESIMS, (1)H NMR, (13)C NMR, DEPT, HSQC, (1)H-(1)H COSY, HMBC, ROESY, and electronic circular dichroism (ECD), as well as ECD calculation. The absolute configuration of 1 was finally established by single crystal X-ray diffraction using Cu Kα radiation. Zephycandidines I (1) and III (3) with new framework types represent the first example of 7-phenyl-hexahydroindole and 5,2'-dimethyl-biphenyl-2-ylamine alkaloids, respectively, and their plausible biosynthetic pathway are proposed...
October 27, 2016: European Journal of Medicinal Chemistry
Xueyuan Cao, Kristine R Crews, James Downing, Jatinder Lamba, Stanley B Pounds
BACKGROUND: As new technologies allow investigators to collect multiple forms of molecular data (genomic, epigenomic, transcriptomic, etc) and multiple endpoints on a clinical trial cohort, it will become necessary to effectively integrate all these data in a way that reliably identifies biologically important genes. METHODS: We introduce CC-PROMISE as an integrated data analysis method that combines components of canonical correlation (CC) and projection onto the most interesting evidence (PROMISE)...
October 6, 2016: BMC Bioinformatics
Ravely Casarotti Orlandelli, Maria de Lourdes Corradi da Silva, Ana Flora Dalberto Vasconcelos, Igor Vivian Almeida, Veronica Elisa Pimenta Vicentini, Alicia Prieto, Maria Dolores Diaz Hernandez, João Lúcio Azevedo, João Alencar Pamphile
This study reports the characterization and antiproliferative activity of exopolysaccharides (EPS) produced by submerged cultures of the endophytes Diaporthe sp. JF766998 and Diaporthe sp. JF767007 isolated from the medicinal plant Piper hispidum Sw. Both strains secreted a crude EPS that, upon size exclusion chromatography, showed to contain a heteropolysaccharide (galactose, glucose and mannose) and a high-molecular weight glucan. Data from methylation analysis, FTIR and NMR spectroscopy ((1)H, COSY, TOCSY and HSQC-DEPT) indicated that the purified glucan consisted of a main chain of glucopyranosyl β-(1→3) linkages substituted at O-6 by glucosyl residues...
January 2017: International Journal of Biological Macromolecules
M Hoffmann, A Fazel, K-G Mews, P Ambrosch
OBJECTIVES: To underline the value of the microendoscopic CO2 -LASER-assisted treatment (MEDCO2 ) for Zenker's diverticulum by investigating a large patient cohort treated in a single medical centre. DESIGN: Retrospective cohort study of consecutive patients. SETTING: Department of Otorhinolaryngology, Head and Neck Surgery, Christian-Albrechts-University Kiel, Germany. PARTICIPANTS: A total of 227 patients with Zenker's diverticulum were treated by MEDCO2 , and the results were compared with those reported in the literature for the open transcervical approach (OTA) and the endoscopic staple-assisted oesophagodiverticulostomy (ESED)...
October 19, 2016: Clinical Otolaryngology
Mamdouh Nabil Samy, John Refaat Fahim, Sachiko Sugimoto, Hideaki Otsuka, Katsuyoshi Matsunami, Mohamed Salah Kamel
Phytochemical investigation of Chorisia chodatii Hassl. leaves led to the isolation of an unusual rearranged megastigmane glycoside; chodatiionoside A (1) and another new megastigmane glycoside; chodatiionoside B (2), together with three known megastigmane glycosides (3-5) and one known flavonoid glycoside (6). Their structures were elucidated by spectroscopic methods including 1D and 2D NMR experiments ((1)H, (13)C, DEPT, COSY, HSQC and HMBC) in combination with HR-ESI-MS, CD and modified Mosher's method. As a result, chodatiionoside A has been elucidated as a first example of an unusual rearranged form of megastigmane...
October 19, 2016: Journal of Natural Medicines
Amani S Awaad, Asmaa Al-Refaie, Reham El-Meligy, Mohamed Zain, Hesham Soliman, Mohamed S Marzoke, Nabil El-Sayed
Oral administration of the total alcohol extract of Convolvulus pilosellifolius Desr. (250 and 500 md/kg) showed potent anti-ulcerogenic activity in absolute ethanol-induced ulcer model in rats; it showed percent protection of control ulcer by 69.2 and 84.6%, respectively, while standard ranitidine (100 mg/kg) exhibited 46.2%. Bio-guided work leads to isolation of two novel compounds (1 and 2), which were identified through (1) H, (13) C NMR, HMPC, HMQC and DEPT as: methyl 2-(hydroxymethyl) octanoate, named as amanitate, and 16-amino-9,13-dimethyl-17-(prop-1-en-2-yl)-hexadecahydro-1H-cyclopenta[a] phenanthren-3-ol, named as asmatol...
December 2016: Phytotherapy Research: PTR
Rasmus Bo Hasselbalch, Louis Lind Plesner, Mia Pries-Heje, Lisbet Ravn, Morten Lind, Rasmus Greibe, Birgitte Nybo Jensen, Lars S Rasmussen, Kasper Iversen
BACKGROUND: Crowding in the emergency department (ED) is a well-known problem resulting in an increased risk of adverse outcomes. Effective triage might counteract this problem by identifying the sickest patients and ensuring early treatment. In the last two decades, systematic triage has become the standard in ED's worldwide. However, triage models are also time consuming, supported by limited evidence and could potentially be of more harm than benefit. The aim of this study is to develop a quicker triage model using data from a large cohort of unselected ED patients and evaluate if this new model is non-inferior to an existing triage model in a prospective randomized trial...
October 10, 2016: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
Monika Stompor
The aim of this research was to select microbial strains capable of transforming flavonoid compounds containing an amino group. 6-Aminoflavone (1) was used as a model compound. Biotransformation of 1 by the cultures of Rhodococcus sp. DSM 364 and Gordonia sp. DSM 44456 bacteria led to 6-acetamidoflavone (2) with the isolated yields in 86% and 93%, respectively. The structure of the product was determined on the basis of spectroscopic data, including NMR spectra ((1)H, (13)C, (1)H-(1)H, (1)H-(13)C, and DEPT 135°), a UV and IR spectrum and HR ESI-MS analysis...
November 10, 2016: Journal of Biotechnology
(no author information available yet)
The present study is primarily aimed at an audience of evolutionary biologists in the broad sense for Parts 1-3, as well as at scientists from other professional disciplines looking for new approaches to explore phenomena in nature. However, the content is in general not written as technical text or filled with equations that make it utterly incomprehensible for 'normal' people, although they would have to skip strictly professional biochemical and biological terms that are a constituent part of the evidence in a scientific sense...
2016: Studies in Health Technology and Informatics
Dae Young Lee, Soo-Im Choi, Se Hee Han, Ye-Joo Lee, Jong-Gil Choi, Young-Seob Lee, Je Hun Choi, Seung-Eun Lee, Geum-Soog Kim
Pseudoshikonin I, the new bioactive constituent of Lithospermi radix, was isolated from this methanol extract by employing reverse-phase medium-pressure liquid chromatography (MPLC) using acetonitrile/water solvent system as eluents. The chemical structure was determined based on spectroscopic techniques, including 1D NMR (¹H, (13)C, DEPT), 2D NMR (gCOSY, gHMBC, gHMQC), and QTOF/MS data. In this study, we demonstrated the effect of pseudoshikonin I on matrix-metalloproteinase (MMPs) activation and expression in interleukin (IL)-1β-induced SW1353 chondrosarcoma cells...
August 18, 2016: International Journal of Molecular Sciences
Dorota Madrzak, Renata Mikołajczak, Grzegorz Kamiński
BACKGROUND: The aim of this study was the assessment of utility of somatostatin receptor scintigraphy (SRS) by SPECT imaging using 99mTc-EDDA/HYNIC-Tyr3-octreotide (99mTc-EDDA/HYNIC-TOC) in patients with neuroendocrine neoplasm (NEN) or suspected NEN, referred to Nuclear Medicine Dept. of Voivodship Specialty Center in Rzeszow. The selected group of patients was referred also to 68Ga PET/CT. The posed question was the ratio of patients for whom PET/CT with 68Ga would change their management...
2016: Nuclear Medicine Review. Central & Eastern Europe
Renata Nowak, Marta Drozd, Ewaryst Mendyk, Marta Lemieszek, Olga Krakowiak, Wanda Kisiel, Wojciech Rzeski, Katarzyna Szewczyk
In the present study, ergosterol peroxide and ergosterol were isolated for the first time from fresh fruit bodies of Hygrophoropsis aurantiaca (False Chanterelle). The substances were characterized mainly by spectroscopic methods (¹H-NMR, (13)C-NMR, DEPT-45, DEPT-90, DEPT-135, 2D-NMR). In our study, a new specific thin layer chromatographic method was developed for determination of ergosterol and ergosterol peroxide in H. aurantiaca extract. The method is based on the separation of n-hexane extract on silica gel (Silica Gel G) TLC plates using the optimized solvent system toluene/ethyl acetate (3:1; v/v)...
July 21, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Changping Wang, Xinyu Wang, Kunyu Dong, Jian Luo, Qiang Zhang, Yiyun Cheng
Near infrared-absorbing hydrogels are used for the repeated photothermal treatments of cancer. However, a long-term retention of hydrogel in the body leads to increased risk of toxicity. Here we developed an injectable and on-demand degradable hydrogel to conduct the repeated photothermal therapies (PTTs). Alginate-calcium hydrogel immobilized dendrimer-encapsulated platinum nanoparticles (DEPts) in its matrix represented excellent biocompatibility, and was degraded upon injecting chelates. Results from the in vivo studies reveal that the hydrogel/DEPts-mediated repeated PTTs suppressed tumor growth efficiently, and the hydrogel was degraded on-demand to allow renal secretion of DEPts out of the body...
October 2016: Biomaterials
Darren A Pollock
The Neotropical eurypine genus Thisiomorphus is revised, based on external structural features of adults. Twelve species are recognized, including the following eleven new species (type areas in parentheses): T. festivus (Panama, Colón Prov.), T. osaensis (Costa Rica, Puntarenas Prov.), T. davidsoni (Brazil, Chapada), T. inaequalis (Ecuador, Napo Prov.), T. caeruleus (Panama, Panamá Prov.), T. brasiliensis (Brazil, Amazonas), T. solisi (Costa Rica, Guanacaste Prov.), T. andrewsi (Panama, Chiriquí Prov.), T...
March 22, 2016: Zootaxa
Purvi Purohit, Kunal Garg, Vikram Singh, Shailendra Dwivedi, Praveen Sharma
Microalbuminuria is an established cardiovascular risk indicator in diabetes, hypertension and the general population. There is lack of information on MAU in healthy obese Indian adults and an ongoing debate whether obese adults deserve targeted identification and clinical intervention for MAU and prediabetes. We aimed to screen the healthy obese, young (group I) and middle aged (group II) adults for prevalence of MAU and prediabetes and study its association with Framingham risk score. The study included 50 healthy obese young (20-30 years) and middle aged adults (31-50 years), attending the outpatient clinic of Dept...
July 2016: Indian Journal of Clinical Biochemistry: IJCB
Bamigboye J Taiwo, Grace O Taiwo, Olujide O Olubiyi, Amos A Fatokun
Chromatographic fractionation of the methanolic extract of Corchorus olitorius (L.) (Tiliaceae), on silica gel yielded two polyphenolic compounds. The structures of the compounds were elucidated as Methyl-1,4,5-tri-O-caffeoyl quinate and trans-3-(4-Hydroxy-3-methoxyphenyl)acrylic anhydride, based on extensive use of spectroscopic techniques such as (1)H and (13)C NMR, DEPT and 2D NMR experiments (COSY, HSQC, HMBC), IR and MS. To establish an initial proof-of-concept for the biological relevance of these compounds, their cytotoxicity against the cancer cell lines HeLa, HL460 and PC3, which might indicate their anti-tumour potential, was assessed...
August 1, 2016: Bioorganic & Medicinal Chemistry Letters
Ilhem Zebiri, Mohamed Haddad, Laurent Duca, Dominique Harakat, Billy Cabanillas, Lucie Paloque, Amandine Scandolera, Michel Sauvain, Elsa Rengifo, Laurence Voutquenne-Nazabadioko
Twelve oleanane saponins, zebiriosides A-L, were isolated from the roots of Dendrobangia boliviana Rusby, together with two known saponins, talunùmoside I and 3-O-β-d-glucuronopyranosyl serjanic acid. These saponins are glycosides of serjanic or phytolaccinic acid. Their structures were established on two basis: first, their spectral data, mainly HR-TOFESIMS, 1D-NMR ((1)H, (13)C, DEPT) and 2D-NMR ((1)H(1)H COSY, TOCSY, HSQC, HMBC, and ROESY), and second by comparison with literature data. These compounds were evaluated for their cytotoxic, antileishmanial and hemolytic activities...
October 2016: Phytochemistry
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