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https://www.readbyqxmd.com/read/28433158/characterization-of-a-sulfated-galactoglucan-from-antrodia-cinnamomea-and-its-anticancer-mechanism-via-tgf%C3%AE-fak-slug-axis-suppression
#1
Mei-Kuang Lu, Tung-Yi Lin, Chun-Hao Hu, Chi-Hsein Chao, Chia-Chuan Chang, Hsien-Yeh Hsu
A sulfated 1,4-β-d-galactoglucan (B86-III) with 1,6-branches was isolated and identified from Antrodia cinnamomea. The repeating unit of B86-III was proposed based on one-dimensional 1D ((1)H, (13)C and DEPT-135) and 2D (DQF-COSY, TOCSY, HSQC and HMBC) NMR spectra. The conformation of the sugars was hypothesized to be a rare boat form instead of a (4)C1 chair form. The sulfate substitutions were suggested to be on the C-2 and C-3 positions, resulting in the following structure: B86-III inhibited the viability of H1975 lung cancer cells via cell apoptosis, including the activation of caspase 3 and PARP...
July 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28423800/project-peach-at-uclh-student-projects-in-healthcare-computing
#2
Navin Ramachandran, Dean Mohamedally, Paul Taylor
A collaboration between clinicians at UCLH and the Dept of Computer Science at UCL is giving students of computer science the opportunity to undertake real healthcare computing projects as part of their education. This is enabling the creation of a significant research computing platform within the Trust, based on open source components and hosted in the cloud, while providing a large group of students with experience of the specific challenges of health IT.
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28345710/desktop-nmr-for-structure-elucidation-and-identification-of-strychnine-adulteration
#3
Kawarpal Singh, Bernhard Blümich
Elucidating the structure of complex molecules is difficult at low magnetic fields due to the overlap of different peak multiplets and second-order coupling effects. This is even more challenging for rigid molecules with small chemical shift differences and with prochiral centers. Since low-field NMR spectroscopy is sometimes presumed as restricted to the analysis of only small and simple molecules, this paper aims at countering this misconception: it demonstrates the use of low-field NMR spectroscopy in chemical forensics for identifying strychnine and its counterions by exploring the chemical shift as a signature in different 1D (1)H and (13)C experiments...
March 27, 2017: Analyst
https://www.readbyqxmd.com/read/28333275/anti-m%C3%A3-llerian-hormone-inhibits-activation-and-growth-of-bovine-ovarian-follicles-in-vitro-and-is-localized-to-growing-follicles
#4
M Y Yang, R A Cushman, J E Fortune
STUDY QUESTION: Does anti-Müllerian hormone (AMH) inhibit activation (initiation of growth) of primordial follicles and attenuate the growth of primary follicles in cattle, an excellent animal model for human ovarian follicular development? SUMMARY ANSWER: AMH inhibited activation of bovine primordial follicles and attenuated the growth of activated follicles in vitro. WHAT IS KNOWN ALREADY: In mice null mutant for AMH, the pool of primordial follicles is depleted prematurely and AMH inhibits follicle activation in vitro...
March 17, 2017: Molecular Human Reproduction
https://www.readbyqxmd.com/read/28330230/isolation-and-biological-evaluation-of-n-4-aminocyclooctyl-3-5-dinitrobenzamide-a-new-semisynthetic-derivative-from-the-mangrove-associated-actinomycete-pseudonocardia-endophytica-vuk-10
#5
Usha Kiranmayi Mangamuri, Muvva Vijayalakshmi, Sudhakar Poda, Bramanandam Manavathi, Bhujangarao Chitturi, Venkateswarlu Yenamandra
The present study was aimed to isolate novel bioactive compounds from actinomycetes species isolated from mangrove habitats. With this connection, Pseudonocardia endophytica (VUK-10) was isolated using dilution plate technique and was examined for its secondary metabolite profiling. After successive purification and spectroscopic characterization viz., FTIR, mass, NMR, DEPT, HMQC, HMBC, and COSY spectroscopy, two compounds were identified including a semi synthetic derivative N-(4-aminocyclooctyl)-3, 5-dinitrobenzamide (1), obtained from the precursor of novel natural product cyclooctane-1,4-diamine (3), along with a known compound 3-((1H-indol-6-yl) methyl) hexahydropyrrolo [1, 2-a] pyrazine-1, 4-dione (2)...
December 2016: 3 Biotech
https://www.readbyqxmd.com/read/28287291/-the-blood-glucose-value-not-necessarily-indicates-correctly-the-cellular-metabolic-state
#6
Kornél Simon, István Wittmann
In clinical recommendations the normalized blood glucose level is declared as the main target in therapy of diabetes mellitus, i.e. the achievement of euglycemia is the main therapeutic goal. This approach suggests, that the normal blood glucose value is the marker of the normal carbohydrate metabolism (eumetabolism), and vice versa: hyperglycemia is associated with abnormal metabolism (dysmetabolism). However the question arises, whether identical blood glucose values do reflect the same intracellular biochemical mechanisms? On the basis of data published in the literature authors try to answer these questions by studying the relations between the short/longterm blood glucose level and the cellular metabolism in different clinical settings characterized by divergent pathophysiological parameters...
March 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/28278658/new-naphthalene-derivative-from-the-leaves-of-cassia-grandis-l
#7
Pham Thi Nhat Trinh, Ngoc Quoc Luan, Mai Dinh Tri, Vu Duy Khanh, Nguyen Huu An, Phan Nhat Minh, Pham Ngoc An, Nguyen Thi Le Thuy, Nguyen Kim Phi Phung, Le Tien Dung
Cassia grandis is used for the treatment of skin disorders, back pain, aches, etc. in Vietnamese traditional medicine. In this paper, phytochemicals of the leaves were investigated. A new naphthalene derivative (1, cassgranon D) and, seven known compounds rutin (2), afzelin (3), quercitrin (4), epicatechin (5), (-)-epiafzelechin (6), isoquercitrin (7) and aloe emodin (8) were isolated from the ethyl acetate and methanol extracts. Their structures were elucidated by spectral evidences (UV, IR, MS, (1)H, (13)C, DEPT, HSQC and HMBC NMR), as well as by comparing with published data...
February 16, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28250656/new-cytotoxic-cembranoid-from-indonesian-soft-coral-sarcophyton-sp
#8
Hedi Indra Januar, Neviaty Putri Zamani, Dedi Soedharma, Ekowati Chasanah
CONTEXT: Sarcophyton is a soft coral species that contains various secondary metabolites with cytotoxic activity. The production of cytotoxic compounds in soft corals is suggested as their allelochemical to win space competition. Therefore, if a particular soft coral species dominates a reef area, it may suggest to contain interesting bioactive compounds. AIMS: This research aimed to characterize the cytotoxic compounds in dominant soft coral species (Sarcophyton sp...
January 2017: Pharmacognosy Research
https://www.readbyqxmd.com/read/28221758/synthesis-and-fabrication-of-collagen-coated-ostholamide-electrospun-nanofiber-scaffold-for-wound-healing
#9
Subramani Kandhasamy, Sathiamurthi Perumal, Balaraman Madhan, Narayanan Umamaheswari, Javid Ahmad Banday, Paramasivan Thirumalai Perumal, Vichangal Pridiuldi Santhanakrishnan
A novel scaffold for effective wound healing treatment was developed utilizing natural product bearing collagen-based biocompatible electrospun nanofibers. Initially, ostholamide (OSA) was synthesized from osthole (a natural coumarin), characterized by (1)H, (13)C, DEPT-135 NMR, ESI-MS, and FT-IR spectroscopy analysis. OSA was incorporated into polyhydroxybutyrate (PHB) and gelatin (GEL), which serve as templates for electrospun nanofibers. The coating of OSA-PHB-GEL nanofibers with collagen resulted in PHB-GEL-OSA-COL nanofibrous scaffold which mimics extracellular matrix and serves as an effective biomaterial for tissue engineering applications, especially for wound healing...
March 1, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28191810/gist-institutional-experience-at-srms-ims-india
#10
Shubhanshu Gupta, Keshri Amit, Ashish Gupta, Tanu Argawal
Gastro-Intestinal Stromal Tumors (GIST) is a malignant, non-epithelial, mesenchymal tumor of the digestive tract that is not uncommon in clinical practice nowadays; diagnosis being based upon immuno-histo-chemical analysis of the resected or biopsied (FNAC) specimen. Abdominal lump with or without intra-luminal bleed is a common mode of presentation. Early diagnosis and appropriate management with surgery and/or Imatinib therapy improves recurrence free survival and may impact overall survival. We present here our institutional experience of four patients, admitted in Onco-Surgery Dept...
September 2016: Gulf Journal of Oncology
https://www.readbyqxmd.com/read/28183048/potential-impurities-of-anxiolytic-drug-clobazam-identification-synthesis-and-characterization-using-hplc-lc-esi-ms-n-and-nmr
#11
Neeraj Kumar, Subba Rao Devineni, Shailendra Kumar Dubey, Pramod Kumar
During the optimization of process, eight impurities (CLB Imp-A to CLB Imp-H) were detected in few of the laboratory batches of clobazam, used as anxiolytic agent, in the range of 0.02-0.12% using gradient HPLC method with UV detection. On the basis of co-spiking analysis, six impurities (CLB Imp-A to -F) enumerated by European Pharmacopoeia, however, not reported in the earlier literature, have been harmonized and found to be two impurities are completely unknown (CLB Imp-G and -H). These two new impurities structures were presumed based on LC-ESI/MS(n) study as 8-chloro-1-methyl-5-phenyl-1,5-dihydro-3H-1,5-benzodiazepine-2,4-dione (CLB Imp-G) and 5-chloro-1-methyl-3-phenyl-1H-benzo[d]imidazol-2(3H)-one (CLB Imp-H)...
January 29, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28152388/spectral-characterization-and-antibacterial-activity-of-an-isolated-compound-from-memecylon-edule-leaves
#12
R Srinivasan, D Natarajan, M S Shivakumar
Memecylon edule Roxb. (Melastamataceae family) is a small evergreen tree reported as having ethnobotanical and pharmacological properties. The present study was aimed to investigate the spectral characterization and antibacterial activity of isolated pure compound (3β-hydroxyurs-12-en-28-oic acid (ursolic acid)) from Memecylon edule leaves by performing bioassay guided isolation method. The structure derivation of isolated compound was done by different spectral studies like UV, FT-IR, LC-MS, CHNS analysis, 1D ((1)H, (13)C and DEPT-135) and 2D-NMR (HSQC and HMBC), respectively...
March 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28146121/a-novel-diterpene-glycoside-with-nine-glucose-units-from-stevia-rebaudiana-bertoni
#13
Indra Prakash, Gil Ma, Cynthia Bunders, Romila D Charan, Catherine Ramirez, Krishna P Devkota, Tara M Snyder
Following our interest in new diterpene glycosides with better taste profiles than that of Rebaudioside M, we have recently isolated and characterized Rebaudioside IX-a novel steviol glycoside-from a commercially-supplied extract of Stevia rebaudiana Bertoni. This molecule contains a hexasaccharide group attached at C-13 of the central diterpene core, and contains three additional glucose units when compared with Rebaudioside M. Here we report the complete structure elucidation-based on extensive Nuclear Magnetic Resonance (NMR) analysis (1H, 13C, Correlation Spectroscopy (COSY), Heteronuclear Single Quantum Coherence-Distortionless Enhancement Polarization Transfer (HSQC-DEPT), Heteronuclear Multiple Bond Correlation (HMBC), 1D Total Correlation Spectroscopy (TOCSY), Nuclear Overhauser Effect Spectroscopy (NOESY)) and mass spectral data-of this novel diterpene glycoside with nine sugar moieties and containing a relatively rare 16 α-linked glycoside...
January 31, 2017: Biomolecules
https://www.readbyqxmd.com/read/28117890/costs-of-food-safety-investments-in-the-meat-and-poultry-slaughter-industries
#14
REVIEW
Catherine L Viator, Mary K Muth, Jenna E Brophy, Gary Noyes
To develop regulations efficiently, federal agencies need to know the costs of implementing various regulatory alternatives. As the regulatory agency responsible for the safety of meat and poultry products, the U.S. Dept. of Agriculture's Food Safety and Inspection Service is interested in the costs borne by meat and poultry establishments. This study estimated the costs of developing, validating, and reassessing hazard analysis and critical control points (HACCP), sanitary standard operating procedures (SSOP), and sampling plans; food safety training for new employees; antimicrobial equipment and solutions; sanitizing equipment; third-party audits; and microbial tests...
January 24, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/28108024/isolation-of-isoflavones-from-iris-kashmiriana-baker-as-potential-anti-proliferative-agents-targeting-nf-kappab
#15
Afroze Alam, Varun Jaiswal, Sohail Akhtar, B S Jayashree, K L Dhar
Cancer is possibly one of the most devastating and complex disease and therefore involves chemotherapy as one of the frontline strategies in its therapy. However, expected toxicity and resistance with chemotherapeutic agents encourage us to use the plant derived natural chemotherapeutic sources at the clinical stage of cancer therapy. In view of this strategy, herein new glycosides and isoflavonoids were isolated from Iris kashmiriana Baker and subjected to structure elucidation followed by their biological evaluation...
April 2017: Phytochemistry
https://www.readbyqxmd.com/read/28095825/no-regrets-young-adult-patients-in-psychiatry-report-positive-reactions-to-biobank-participation
#16
Janet L Cunningham, Manuel Zanzi, Mimmie Willebrand, Lisa Ekselius, Mia Ramklint
BACKGROUND: Research in vulnerable individuals must insure voluntariness and minimize negative reactions caused by participation. This study aimed to describe consent and completion rate in young psychiatric patients in relation to study components, degree of disability and to compare response to research participation in patients and controls. METHODS: Between 2012 and 2015, 463 patients with psychiatric disorders between the ages of 18-25 from the Dept. of General Psychiatry at Uppsala University Hospital and 105 controls were recruited to donate data and samples to a biobank...
January 17, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28024540/extraction-and-characterization-of-pectins-from-primary-cell-walls-of-edible-a%C3%A3-a%C3%A3-euterpe-oleraceae-berries-fruits-of-a-monocotyledon-palm
#17
Thaisa Moro Cantu-Jungles, Marcello Iacomini, Thales R Cipriani, Lucimara M C Cordeiro
Açaí berries (Euterpe oleracea) are greatly consumed in Brazil and exported to other countries as a nutritional supplement, due to health benefits attributed to its consumption. However, the complete chemical structure of bioactive polysaccharides was not fully elucidated yet. In this work, we characterize pectic polysaccharides from açaí berries through monosaccharide composition, HPSEC, methylation and (13)C and (1)H/(13)C HSQC-DEPT-NMR analyses. A highly methoxylated homogalacturonan with a DM of 88% and Mw of 22kDa together with small amounts of a mannoglucan were found...
February 20, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/27988702/nine-new-i-trechisibus-i-species-from-peru-and-argentina-coleoptera-carabidae-trechinae
#18
Gianni Allegro, Pier Mauro Giachino
Nine new Trechisibus species are described, four from Central Peru (T. huascarani n. sp. and T. recuayi n. sp. from Dept. Ancash, T. curtii n. sp. and T. lemairei n. sp. from Dept. Huanuco) and five from Patagonian Argentina, Province of Rio Negro (T. brevis n. sp., T. longipenis n. sp., T. parvulus n. sp., T. sciakyi n. sp., T. striatus n. sp.).
November 15, 2016: Zootaxa
https://www.readbyqxmd.com/read/27973724/investigations-on-antioxidant-antiproliferative-and-cox-2-inhibitory-potential-of-alkaloids-from-anthocephalus-cadamba-roxb-miq-leaves
#19
Madhu Chandel, Manish Kumar, Upendra Sharma, Bikram Singh, Satwinderjeet Kaur
In the present study, an ayurvedic medicinal plant, Anthocephalus cadamba (Roxb.) Miq. commonly known as 'Kadamb' was explored for its potential against oxidative stress and cancer. The fractions namely AC-4 and ACALK (alkaloid rich fraction) were isolated from A. cadamba leaves by employing two different isolation methods and evaluated for their in vitro antioxidant and antiproliferative activity. The structure of the isolated AC-4 was characterized tentatively as dihydrocadambine by using various spectroscopic techniques such as ESI-QTOF-MS, (1) H- and (13) C-NMR, DEPT, COSY, HMQC, and HMBC...
April 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/27823880/amaryllidaceae-alkaloids-with-new-framework-types-from-zephyranthes-candida-as-potent-acetylcholinesterase-inhibitors
#20
Guanqun Zhan, Junjun Liu, Junfei Zhou, Bin Sun, Haji Akber Aisa, Guangmin Yao
Three new Amaryllidaceae alkaloids, named zephycandidines I-III (1-3), were isolated from Zephyranthes candida. The structures of 1-3 were elucidated by spectroscopic analyses including HRESIMS, (1)H NMR, (13)C NMR, DEPT, HSQC, (1)H-(1)H COSY, HMBC, ROESY, and electronic circular dichroism (ECD), as well as ECD calculation. The absolute configuration of 1 was finally established by single crystal X-ray diffraction using Cu Kα radiation. Zephycandidines I (1) and III (3) with new framework types represent the first example of 7-phenyl-hexahydroindole and 5,2'-dimethyl-biphenyl-2-ylamine alkaloids, respectively, and their plausible biosynthetic pathway are proposed...
February 15, 2017: European Journal of Medicinal Chemistry
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