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piracetam in stroke

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https://www.readbyqxmd.com/read/28916907/pharmacokinetic-study-of-piracetam-in-focal-cerebral-ischemic-rats
#1
Pankaj Paliwal, Debabrata Dash, Sairam Krishnamurthy
BACKGROUND AND OBJECTIVE: Cerebral ischemia affects hepatic enzymes and brain permeability extensively. Piracetam was investigated up to phase III of clinical trials and there is lack of data on brain penetration in cerebral ischemic condition. Thus, knowledge of the pharmacokinetics and brain penetration of piracetam during ischemic condition would aid to improve pharmacotherapeutics in ischemic stroke. METHODS: Focal cerebral ischemia was induced by middle cerebral artery occlusion for 2 h in male Wistar rats followed by reperfusion...
September 15, 2017: European Journal of Drug Metabolism and Pharmacokinetics
https://www.readbyqxmd.com/read/28756557/effects-of-central-nervous-system-drugs-on-recovery-after-stroke-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#2
REVIEW
See-Hwee Yeo, Zheng-Jie Ian Lim, Jia Mao, Wai-Ping Yau
BACKGROUND AND OBJECTIVE: Pilot trials have suggested that pharmacotherapy may aid stroke recovery. The aim of this study was to systematically review the effects of antidepressants, anti-Alzheimer drugs, anti-Parkinson drugs, central nervous system (CNS) stimulants and piracetam on gross motor function, cognition, disability, dependency and quality of life (QOL) after stroke. METHODS: PubMed, EMBASE and the Cochrane Central Register of Controlled Trials databases were searched, and 44 randomized controlled trials that compared outcomes of interest between drug treatment and placebo or no treatment were included...
July 29, 2017: Clinical Drug Investigation
https://www.readbyqxmd.com/read/27349046/-characteristics-of-ischemic-stroke-in-children-in-the-years-1968-1998-and-2010-2015
#3
Izabela Witek, Sławomir Kroczka, Marek Kaciński
BACKGROUND: Ischemic strokes in children are rare. The etiology and risk factors for ischemic stroke in children and adolescence differ from those typical in adults. Clinical symptoms depend on the location, extent of damage of the central nervous system and age. The aim of the study was to compare the clinical picture of ischemic stroke in children at two periods. MATERIAL AND METHODS: The study included children who had a stroke: 32 children (group I) in the years 1968-1998 and 27 children (group II) in 2010-2015...
2016: Przegla̧d Lekarski
https://www.readbyqxmd.com/read/27236454/piracetam-for-aphasia-in-post-stroke-patients-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#4
REVIEW
Jie Zhang, Ruili Wei, Zhongqin Chen, Benyan Luo
BACKGROUND: Aphasia is a common symptom in post-stroke patients. Piracetam is a commonly used nootropic agent that promises various benefits to brain function, including language improvement. OBJECTIVE: We performed a systematic review and meta-analysis to assess whether piracetam facilitates the rehabilitation of language performance in post-stroke patients. METHODS: Randomized controlled trials (RCTs) of piracetam treatment in post-stroke patients published in any language were included, excluding those involving pre-existing cognitive disorders such as dementia and mood disturbances...
July 2016: CNS Drugs
https://www.readbyqxmd.com/read/26287434/prescription-of-ineffective-neuroprotective-drugs-to-stroke-patients-a-cross-sectional-study-in-north-indian-population
#5
Kapil Kumar Singhal, Kameshwar Prasad, Rohit Bhatia, Amit Kumar, Mamta Bhusan Singh
In a developing country, where patient access to tertiary care is limited and most patients have to pay out of pocket, it is imperative for the physicians to practice evidence-based medicine. Reports on prescription details and surveys are not available. The aim of this study is to describe the prescribing patterns for various medications used in the treatment of stroke among the first contact physicians in North India; to estimate the proportion of patients being prescribed the non-recommended drugs and to determine any relationship between the economic status of the patient and the prescription pattern...
August 2016: International Journal of Neuroscience
https://www.readbyqxmd.com/read/26182605/-zonisamide-first-choice-among-the-first-line-antiepileptic-drugs-in-focal-epilepsy
#6
REVIEW
József Janszky, Réka Horvath, Sámuel Komoly
Chronic administration of antiepileptic drugs without history of unprovoked epileptic seizures are not recommended for epilepsy prophylaxis. Conversely, if the patient suffered the first unprovoked seizure, then the presence of epileptiform discharges on the EEG, focal neurological signs, and the presence of epileptogenic lesion on the MRI are risk factors for a second seizure (such as for the development of epilepsy). Without these risk factors, the chance of a second seizure is about 25-30%, while the presence of these risk factors (for example signs of previous stroke, neurotrauma, or encephalitis on the MRI) can predict >70% seizure recurrence...
May 30, 2015: Ideggyógyászati Szemle
https://www.readbyqxmd.com/read/25385363/effects-of-phenobarbital-and-levetiracetam-on-pr-and-qtc-intervals-in-patients-with-post-stroke-seizure
#7
MULTICENTER STUDY
Antonio Siniscalchi, Francesco Scaglione, Enzo Sanzaro, Francesco Iemolo, Giorgio Albertini, Gianluca Quirino, Maria Teresa Manes, Santo Gratteri, Nicola Biagio Mercuri, Giovambattista De Sarro, Luca Gallelli
BACKGROUND AND OBJECTIVES: Sudden unexplained/unexpected death (SUDEP) is related to high mortality in patients with epilepsy. The prolongation of QT interval, involved in cardiac arrhythmia-related SUDEP, may be precipitated by antiepileptic drugs (AEDs). In this study, we evaluated the effects of phenobarbital and levetiracetam on PR-QTc intervals in patients with post-stroke seizures. METHODS: We performed an open-label, parallel group, prospective, multicenter study between June 2009 and December 2013 in patients older than 18 years of age with a clinical diagnosis of post-stroke seizure and treated with phenobarbital or levetiracetam...
December 2014: Clinical Drug Investigation
https://www.readbyqxmd.com/read/24576803/the-impact-of-stroke-on-cognitive-processing-a-prospective-event-related-potential-study
#8
RANDOMIZED CONTROLLED TRIAL
Leandra Stahlhut, Karl-Heinz Grotemeyer, Ingo-W Husstedt, Stefan Evers
BACKGROUND AND PURPOSE: Stroke is often associated with cognitive decline which can be evaluated by event-related potentials (ERP). So far, only little is known about the impact of stroke on ERP. The aim of this prospective study was to follow-up ERP latencies in stroke patients and to evaluate the influence of sex, vascular territory of stroke, reinfarction, and secondary prevention (acetylsalicylic acid versus piracetam). METHODS: Visually evoked ERP were recorded in 563 stroke patients at baseline (i...
April 15, 2014: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/24236205/the-antiepileptic-drug-levetiracetam-suppresses-non-convulsive-seizure-activity-and-reduces-ischemic-brain-damage-in-rats-subjected-to-permanent-middle-cerebral-artery-occlusion
#9
Ornella Cuomo, Vincenzo Rispoli, Antonio Leo, Giovanni Bosco Politi, Antonio Vinciguerra, Gianfranco di Renzo, Mauro Cataldi
The antiepileptic drug Levetiracetam (Lev) has neuroprotective properties in experimental stroke, cerebral hemorrhage and neurotrauma. In these conditions, non-convulsive seizures (NCSs) propagate from the core of the focal lesion into perilesional tissue, enlarging the damaged area and promoting epileptogenesis. Here, we explore whether Lev neuroprotective effect is accompanied by changes in NCS generation or propagation. In particular, we performed continuous EEG recordings before and after the permanent occlusion of the middle cerebral artery (pMCAO) in rats that received Lev (100 mg/kg) or its vehicle immediately before surgery...
2013: PloS One
https://www.readbyqxmd.com/read/23438654/safety-in-pharmacological-enhancement-of-stroke-rehabilitation
#10
REVIEW
S T Engelter
Pharmacological enhancement of neurorehabilitation is based on the concept of neuroplasticity. Agents with probably unfavourable effects on recovery (e.g. classical antiepileptic drugs, butyrophenones) should be avoided. The findings of experimental studies in animal models, investigations in healthy subjects and the findings of neurophysiological studies indicate that there is scope for benefit from pharmacological enhancement in stroke rehabilitation in the clinical setting - in addition to rehabilitative therapies...
April 2013: European Journal of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/23250593/-assessment-of-multimodal-effect-of-cytoflavin-in-the-acute-brain-stroke-in-patients-with-metabolic-syndrome
#11
RANDOMIZED CONTROLLED TRIAL
M M Asadullaev, F S Saidvaliev, F K Shermukhamedova, Zh K Rizvonov, N M Vakhabova
Sixty patients were randomized to treatment with cytoflavin (n=30) or nootropil (n=30). Patients of the main group received cytoflavin along with standard treatment for correction of hemodynamics. The treatment scheme was as follows: intravenous injections during 10 days, tablets - from 11 to 35 days. The same scheme of treatment was used in the comparison group. The total duration was 35 days. Patients were assessed with NIHSS, the Rankin scale, the Barthel index, MMSE. MRI was used to verify ischemic lesions...
2012: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/23192717/therapeutic-interventions-for-aphasia-initiated-more-than-six-months-post-stroke-a-review-of-the-evidence
#12
REVIEW
Laura Allen, Swati Mehta, J Andrew McClure, Robert Teasell
BACKGROUND: Aphasia effects up to 38% of acute stroke patients. For many of these individuals, this condition persists far beyond the acute phase. The purpose of this review is to evaluate the effectiveness of therapeutic interventions for aphasia initiated more than 6 months post stroke. METHODS: A literature search was conducted for articles in which aphasia treatments were initiated more than 6 months post stroke. Searches were conducted in multiple databases including MEDLINE, Scopus, CINAHL, and EMBASE...
November 2012: Topics in Stroke Rehabilitation
https://www.readbyqxmd.com/read/23186990/cognitive-enhancers-nootropics-part-3-drugs-interacting-with-targets-other-than-receptors-or-enzymes-disease-modifying-drugs
#13
REVIEW
Wolfgang Froestl, Andrea Pfeifer, Andreas Muhs
Cognitive enhancers (nootropics) are drugs to treat cognition deficits in patients suffering from Alzheimer's disease, schizophrenia, stroke, attention deficit hyperactivity disorder, or aging. Cognition refers to a capacity for information processing, applying knowledge, and changing preferences. It involves memory, attention, executive functions, perception, language, and psychomotor functions. The term nootropics was coined in 1972 when memory enhancing properties of piracetam were observed in clinical trials...
2013: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/23128439/levetiracetam-versus-carbamazepine-in-patients-with-late-poststroke-seizures-a-multicenter-prospective-randomized-open-label-study-epic-project
#14
RANDOMIZED CONTROLLED TRIAL
D Consoli, D Bosco, P Postorino, F Galati, M Plastino, G F Perticoni, G A Ottonello, B Passarella, S Ricci, G Neri, D Toni
BACKGROUND: Strokes are the leading cause of epileptic seizures in adults and account for 50% of seizures in those over the age of 65 years. The use of antiepileptic drugs to prevent recurrent poststroke seizures is recommended. METHODS: One hundred and twenty-eight patients with poststroke seizures were randomly allocated to treatment with either levetiracetam (LEV) or sustained-release carbamazepine (CBZ) in a multicenter randomized open-label study. After a titration study phase (2 weeks), the optimal individual dose of trial medication was determined and treatment was continued for another 52 weeks...
2012: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/23042218/cognitive-enhancers-nootropics-part-2-drugs-interacting-with-enzymes
#15
REVIEW
Wolfgang Froestl, Andreas Muhs, Andrea Pfeifer
Cognitive enhancers (nootropics) are drugs to treat cognition deficits in patients suffering from Alzheimer's disease, schizophrenia, stroke, attention deficit hyperactivity disorder, or aging. Cognition refers to a capacity for information processing, applying knowledge, and changing preferences. It involves memory, attention, executive functions, perception, language, and psychomotor functions. The term nootropics was coined in 1972 when memory enhancing properties of piracetam were observed in clinical trials...
2013: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/22983240/-the-results-of-the-use-of-levetiracetam-keppra-in-post-stroke-epilepsy
#16
A Kh Magomedova, M M Magomedov, A M Magomedova, M F Magomaev
No abstract text is available yet for this article.
2012: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/22972044/piracetam-for-acute-ischaemic-stroke
#17
REVIEW
Stefano Ricci, Maria Grazia Celani, Teresa Anna Cantisani, Enrico Righetti
BACKGROUND: Piracetam has neuroprotective and antithrombotic effects that may help to reduce death and disability in people with acute stroke. This is an update of a Cochrane Review first published in 1999, and previously updated in 2006 and 2009. OBJECTIVES: To assess the effects of piracetam in acute, presumed ischaemic stroke. SEARCH METHODS: We searched the Cochrane Stroke Group Trials Register (last searched 15 May 2011), the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2011, Issue 2), MEDLINE (1966 to May 2011), EMBASE (1980 to May 2011), and ISI Science Citation Index (1981 to May 2011)...
September 12, 2012: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/22925226/levetiracetam-in-patients-with-central-neuropathic-post-stroke-pain-a-randomized-double-blind-placebo-controlled-trial
#18
RANDOMIZED CONTROLLED TRIAL
G J Jungehulsing, H Israel, N Safar, B Taskin, C H Nolte, P Brunecker, K-D Wernecke, A Villringer
BACKGROUND AND PURPOSE: Central post-stroke pain (CPSP) is a severe chronic neuropathic pain condition defined as a spontaneous pain or allodynia corresponding to a vascular lesion. It usually evolves weeks after stroke, and can distinctively impair the quality of life. Treatment is complex and mostly unsatisfactory. We hypothesized that the anti-epileptic drug levetiracetam (LEV) improves CPSP compared with placebo. The purpose of this study was to examine the efficacy and tolerability of LEV in patients with CPSP...
February 2013: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/22886028/cognitive-enhancers-nootropics-part-1-drugs-interacting-with-receptors
#19
REVIEW
Wolfgang Froestl, Andreas Muhs, Andrea Pfeifer
Cognitive enhancers (nootropics) are drugs to treat cognition deficits in patients suffering from Alzheimer's disease, schizophrenia, stroke, attention deficit hyperactivity disorder, or aging. Cognition refers to a capacity for information processing, applying knowledge, and changing preferences. It involves memory, attention, executive functions, perception, language, and psychomotor functions. The term nootropics was coined in 1972 when memory enhancing properties of piracetam were observed in clinical trials...
2012: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/21768841/postpartum-cerebral-venous-thrombosis
#20
Jill A McCaulley, Jason A Pates
BACKGROUND: Cerebral venous thrombosis is a rare entity in pregnancy and the postpartum period, with an incidence of 1:10,000 to 1:25,000. CASE: A 19-year-old woman, gravida 1, para 1, presented to the emergency department on postpartum day 7, having experienced seizures. Severe preeclampsia had been diagnosed during the antepartum period. The patient initially was diagnosed with postpartum eclampsia and started on magnesium sulfate for seizure prophylaxis. Magnetic resonance imaging later showed cerebral venous thrombosis of the left transverse sinus and right frontal and left frontoparietal cortical veins...
August 2011: Obstetrics and Gynecology
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