Gabor Csukly, László Tombor, Zoltan Hidasi, Eva Csibri, Máté Fullajtár, Zsolt Huszár, Vanda Koszovácz, Orsolya Lányi, Edit Vass, Boróka Koleszár, István Kóbor, Katalin Farkas, Viktoria Rosenfeld, Dalida Borbála Berente, Gergo Bolla, Mate Kiss, Anita Kamondi, Andras Attila Horvath
Evidence suggests that depressive symptomatology is a consequence of network dysfunction rather than lesion pathology. We studied whole-brain functional connectivity using a Minimum Spanning Tree as a graph-theoretical approach. Furthermore, we examined functional connectivity in the Default Mode Network, the Frontolimbic Network (FLN), the Salience Network, and the Cognitive Control Network. All 183 elderly subjects underwent a comprehensive neuropsychological evaluation and a 3 Tesla brain MRI scan. To assess the potential presence of depressive symptoms, the 13-item version of the Beck Depression Inventory (BDI) or the Geriatric Depression Scale (GDS) was utilized...
April 5, 2024: Translational Psychiatry