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https://www.readbyqxmd.com/read/28712187/utility-of-heart-type-fatty-acid-binding-protein-h-fabp-point-of-care-test-in-the-early-hours-of-stemi-compared-with-troponin-i-in-pakistani-population
#1
Walid Ahmad Abbasi, Muhammad Saleem, Shahid Rasheed, Azhar Mahmood Kiyani
BACKGROUND: Acute coronary syndrome remains a dominant cause of high morbidity and mortality despite advancements in treatment This study was conducted to examine the utility of point-of-care test of heart-type fatty-acid binding protein (h-FABP) and compare it with the point-of-care test of cardiac troponin I (cTnI) in the first 06 hours of STEMI. METHODS: This cross-sectional, comparative study which was conducted in Rawalpindi institute of cardiology, Rawalpindi, Pakistan, from January to June 2015...
January 2017: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/28597800/effect-of-dobutamine-stress-echocardiography-on-serum-heart-fatty-acid-binding-protein-levels
#2
Sinan Akinci, Akif Serhat Balcioğlu, Gülten Taçoy, Yusuf Tavil, Özlem Gülbahar, Murat Özdemir
Objective Heart fatty acid binding protein (HFABP) is a low-molecular-weight free protein that is abundant in the intracytoplasmic space of myocytes. Due to its unique features, serum HFABP levels may increase in myocardial ischaemia. The aim of this study was to evaluate the effect of myocardial ischaemia induced by dobutamine stress echocardiography (DSE) on serum HFABP levels. Methods and results A total of 30 consecutive patients with suspected myocardial ischaemia underwent DSE examination. HFABP levels were measured immediately before and 1 hour after DSE...
April 2017: Acta Cardiologica
https://www.readbyqxmd.com/read/28486916/are-markers-of-cardiac-dysfunction-useful-in-the-assessment-of-cardiovascular-risk-in-dialysis-patients
#3
Beata Franczyk, Anna Gluba-Brzózka, Piotr Bartnicki, Maciej Banach, Jacek Rysz
Cardiovascular morbidity and mortality of dialysis patients is a major problem in this group. The purpose of this study was also to evaluate whether any of studied markers are better than troponin in early detection of the occurrence of ventricular arrhythmias and prolongation of QT interval. This study included 45 patients undergoing haemodialysis. ECG Holter and echocardiographic examination were performed before and after dialysis. The concentration of markers: copeptin, GDF-15, HFABP and troponin were measured with the use of ELISA tests...
May 8, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28355230/a-blood-based-biomarker-panel-to-risk-stratify-mild-traumatic-brain-injury
#4
Richa Sharma, Alexandra Rosenberg, Ellen R Bennett, Daniel T Laskowitz, Shawn K Acheson
Mild traumatic brain injury (TBI) accounts for the vast majority of the nearly two million brain injuries suffered in the United States each year. Mild TBI is commonly classified as complicated (radiographic evidence of intracranial injury) or uncomplicated (radiographically negative). Such a distinction is important because it helps to determine the need for further neuroimaging, potential admission, or neurosurgical intervention. Unfortunately, imaging modalities such as computed tomography (CT) and magnetic resonance imaging (MRI) are costly and not without some risk...
2017: PloS One
https://www.readbyqxmd.com/read/28093987/the-prognostic-value-of-heart-type-fatty-acid-binding-protein-in-patients-with-suspected-acute-coronary-syndrome-a-systematic-review
#5
Julia D Jones, Pei Gee Chew, Rebecca Dobson, Andrew Wootton, Reza Ashrafi, Aleem Khand
BACKGROUND: Heart type fatty acid protein(HFABP) is a cytosolic protein released early after acute coronary syndrome(ACS) even in the absence of myocardial necrosis. OBJECTIVES: The purpose of this systematic review was to determine whether HFABP levels in patients with suspected, or confirmed ACS, improves risk stratification when added to established means of risk assessment. METHODS: We searched Medline, Pubmed and Embase databases from inception to July 2015 to identify prospective studies with suspected or confirmed ACS, who had HFABP measured during the index admission with at least 1 month follow up data...
January 16, 2017: Current Cardiology Reviews
https://www.readbyqxmd.com/read/27966485/metabolic-alterations-derived-from-absence-of-two-pore-channel-1-at-cardiac-level
#6
Vanessa Garcia-Rua, Sandra Feijoo-Bandin, Maria Garcia-Vence, Alana Aragon-Herrera, Susana B Bravo, Diego Rodriguez-Penas, Ana Mosquera-Leal, Pamela V Lear, John Parrington, Jana Alonso, Esther Rosello-Lleti, Manuel Portoles, Miguel Rivera, Jose Ramon Gonzalez-Juanatey, Francisca Lago
Two-pore channels (TPCs or TPCNs) are novel voltage-gated ion channels that have been postulated to act as Ca2+ and/or Na+ channels expressed exclusively in acidic organelles such as endosomes and lysosomes. TPCNs participate in the regulation of diverse biological processes and recently have been proposed to be involved in the pathophysiology of metabolic disorders such as obesity, fatty liver disease and type 2 diabetes mellitus. Due to the importance of these pathologies in the development of cardiovascular diseases, we aimed to study the possible role of two-pore channel 1 (TPCN1) in the regulation of cardiac metabolism...
December 2016: Journal of Biosciences
https://www.readbyqxmd.com/read/27596162/the-serum-heart-type-fatty-acid-binding-protein-hfabp-levels-can-be-used-to-detect-the-presence-of-acute-kidney-injury-on-admission-in-patients-admitted-to-the-non-surgical-intensive-care-unit
#7
Akihiro Shirakabe, Nobuaki Kobayashi, Noritake Hata, Takuro Shinada, Kazunori Tomita, Masafumi Tsurumi, Hirotake Okazaki, Masato Matsushita, Yoshiya Yamamoto, Shinya Yokoyama, Kuniya Asai, Wataru Shimizu
BACKGROUND: No cardiac biomarkers for detecting acute kidney injury (AKI) on admission in non-surgical intensive care patients have been reported. The aim of the present study is to elucidate the role of cardiac biomarkers for quickly identifying the presence of AKI on admission. METHODS: Data for 1183 patients who underwent the measurement of cardiac biomarkers, including the serum heart-type fatty acid-binding protein (s-HFABP) level, in the emergency department were screened, and 494 non-surgical intensive care patients were enrolled in this study...
September 5, 2016: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/27372431/increment-of-hfabp-level-in-coronary-artery-in-stent-restenosis-segments-in-diabetic-and-nondiabetic-minipigs-hfabp-overexpression-promotes-multiple-pathway-related-inflammation-growth-and-migration-in-human-vascular-smooth-muscle-cells
#8
Kang Chen, Qiu Jing Chen, Ling Jie Wang, Zhu Hui Liu, Qi Zhang, Ke Yang, Hai Bo Wang, Xiao Xiang Yan, Zhen Bin Zhu, Run Du, Rui Yan Zhang, Wei Feng Shen, Lin Lu
BACKGROUND: Our previous study suggested that heart-type fatty acid-binding protein (HFABP) levels were greatly elevated in the conditioned medium of explant culture of in-stent restenosis (ISR) tissue from diabetic minipigs compared with those of non-ISR tissue. We here verified this result in animal tissues and investigated the impact of HFABP overexpression in human aortic smooth muscle cells (hASMCs). METHODS AND RESULTS: In Western blot and real-time RT-PCR, HFABP protein and mRNA levels were significantly higher in ISR than in non-ISR tissues from minipigs, and higher in the ISR tissue from diabetic minipigs than that from nondiabetic minipigs...
2016: Journal of Vascular Research
https://www.readbyqxmd.com/read/27138236/levosimendan-versus-dobutamine-in-myocardial-injury-patients-with-septic-shock-a-randomized-controlled-trial
#9
RANDOMIZED CONTROLLED TRIAL
Jianb-biao Meng, Ma-hong Hu, Zhi-zhen Lai, Chun-lian Ji, Xiu-juan Xu, Geng Zhang, Shuyuan Tian
BACKGROUND We aimed to investigate the effect of levosimendan on biomarkers of myocardial injury and systemic hemodynamics in patients with septic shock. MATERIAL AND METHODS After achieving normovolemia and a mean arterial pressure of at least 65 mmHg, 38 septic shock patients with low cardiac output (left ventricular ejective fraction), LEVF £45%) were randomly divided into two groups: levosimendan dobutamine. Patients in the levosimendan and dobutamine groups were maintained with intravenous infusion of levosimendan (0...
May 3, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/27068280/csf-and-blood-biomarkers-for-the-diagnosis-of-alzheimer-s-disease-a-systematic-review-and-meta-analysis
#10
REVIEW
Bob Olsson, Ronald Lautner, Ulf Andreasson, Annika Öhrfelt, Erik Portelius, Maria Bjerke, Mikko Hölttä, Christoffer Rosén, Caroline Olsson, Gabrielle Strobel, Elizabeth Wu, Kelly Dakin, Max Petzold, Kaj Blennow, Henrik Zetterberg
BACKGROUND: Alzheimer's disease biomarkers are important for early diagnosis in routine clinical practice and research. Three core CSF biomarkers for the diagnosis of Alzheimer's disease (Aβ42, T-tau, and P-tau) have been assessed in numerous studies, and several other Alzheimer's disease markers are emerging in the literature. However, there have been no comprehensive meta-analyses of their diagnostic performance. We systematically reviewed the literature for 15 biomarkers in both CSF and blood to assess which of these were most altered in Alzheimer's disease...
June 2016: Lancet Neurology
https://www.readbyqxmd.com/read/27046953/components-of-boiogito-suppress-the-progression-of-hypercholesterolemia-and-fatty-liver-induced-by-high-cholesterol-diet-in-rats
#11
Weibin Qian, Junichi Hasegawa, Xinrui Cai, Jie Yang, Yoshitaka Ishihara, Bingqiong Ping, Satoshi Tsuno, Yusuke Endo, Akiko Matsuda, Norimasa Miura
BACKGROUND: Ogi, one main component of boiogito (BOT), is reported to have an effect on hypercholesterolemia and NAFLD. In this experiment, we examined effects of ogi on the progression of hypercholesterolemia and fatty liver induced by high-cholesterol diet in rats and compared with the effects of ogi combined with ginger or hesperidin. METHODS: Hypercholesterolemia and fatty liver were induced by a high cholesterol diet in rats. Extract of ogi, ogi with hesperidin, and ogi with ginger were added to the high-cholesterol diet, respectively...
March 2016: Yonago Acta Medica
https://www.readbyqxmd.com/read/26867681/neonatal-phthalate-ester-exposure-induced-placental-mts-fatp1-and-hfabp-mrna-expression-in-two-districts-of-southeast-china
#12
Bin Li, Xijin Xu, Yueqin Zhu, Junjun Cao, Yuling Zhang, Xia Huo
Plastic production releases phthalate esters (PAEs), which can alter the expression of metallothioneins (MTs), fatty acid transport protein 1 (FATP1) and heart fatty acid binding protein (HFABP). A total of 187 mother-infant pairs were recruited, 127 from Chenghai (high exposed group) and 60 from Haojiang (low exposed group), to investigate the association between neonatal PAE exposure and mRNA expression of placental MTs, FATP1 and HFABP. Umbilical cord blood and placenta samples were collected for measuring five PAE concentrations and detecting mRNA levels of MTs, FATP1 and HFABP...
February 12, 2016: Scientific Reports
https://www.readbyqxmd.com/read/26820671/molecular-and-biochemical-evidence-on-the-protective-effects-of-embelin-and-carnosic-acid-in-isoproterenol-induced-acute-myocardial-injury-in-rats
#13
COMPARATIVE STUDY
Cengiz Kocak, Fatma Emel Kocak, Raziye Akcilar, Ozben Ozden Isiklar, Havva Kocak, Zeynep Bayat, Hasan Simsek, Figen Taser, Irfan Altuntas
AIMS: Acute myocardial infarction is a serious acute cardiac disorder and heart disease is still a major public health problem in adults. We investigated the effects of embelin (EMB) and carnosic acid (CA) in animals with isoproterenol (ISO)-induced myocardial injury. MAIN METHODS: Adult male Wistar-Albino rats were divided into four groups: control, ISO, ISO with EMB, and ISO with CA. Before myocardial injury was induced, drugs were administered by oral gavage...
February 15, 2016: Life Sciences
https://www.readbyqxmd.com/read/26645262/evaluation-of-cardiac-biomarkers-and-right-ventricular-dysfunction-in-patients-with-acute-pulmonary-embolism
#14
Neşe Dursunoğlu, Dursun Dursunoğlu, Ali İhsan Yıldız, Simin Rota
OBJECTIVE: Right ventricular dysfunction (RVD) with myocardial damage may lead to fatal complications in patients with acute pulmonary embolism (PE). Cytoplasmic heart-type fatty acid-binding protein (HFABP) and the N-terminal fragment of its prohormone (NT-proBNP) are sensitive and specific biomarkers of myocardial damage. We evaluated RVD and cardiac biomarkers for myocardial damage and short-term mortality in patients with acute PE. METHODS: We analyzed 41 patients (24 females, 17 males) with confirmed acute PE prospective...
April 2016: Anatolian Journal of Cardiology
https://www.readbyqxmd.com/read/26317036/diagnosis-of-non-st-elevation-acute-coronary-syndrome-by-the-measurement-of-heart-type-fatty-acid-binding-protein-in-serum-a-prospective-case-control-study
#15
Priscilla Abraham Chandran, Basharat Ara Wani, Oruganti Sai Satish, Noorjahan Mohammed
A prospective case control study was undertaken to evaluate the diagnostic performance of serum heart-type fatty acid binding protein (HFABP) in comparison to cardiac TnT and TnI in 33 patients admitted with chest pain, diagnosed as NSTE-ACS (non ST elevation acute coronary syndrome) and 22 healthy controls. Area under the receiver operating curve (AUC) was highest for H-FABP (AUC 0.79; 95% CI 0.66-0.89) versus cTnI (AUC 0.73; 95% CI 0.59-0.84) and cTnT (AUC 0.71; 95% CI 0.57-0.83). The H-FABP level above 6...
2014: Journal of Biomarkers
https://www.readbyqxmd.com/read/26248795/fatty-acid-binding-proteins-expressed-at-the-human-blood-brain-barrier-bind-drugs-in-an-isoform-specific-manner
#16
Gordon S Lee, Katharina Kappler, Christopher J H Porter, Martin J Scanlon, Joseph A Nicolazzo
PURPOSE: To examine the expression of fatty acid binding proteins (FABPs) at the human blood-brain barrier (BBB) and to assess their ability to bind lipophilic drugs. METHODS: mRNA and protein expression of FABP subtypes in immortalized human brain endothelial (hCMEC/D3) cells were examined by RT-qPCR and Western blot, respectively. FABPs that were found in hCMEC/D3 cells (hFABPs) were recombinantly expressed and purified from Escherichia coli C41(DE3) cells. Drug binding to these hFABPs was assessed using a fluorescence assay, which measured the ability of a panel of lipophilic drugs to displace the fluorescent probe compound 1-anilinonaphthalene-8-sulfonic acid (ANS)...
October 2015: Pharmaceutical Research
https://www.readbyqxmd.com/read/26072112/ischemic-biomarker-heart-type-fatty-acid-binding-protein-hfabp-in-acute-heart-failure-diagnostic-and-prognostic-insights-compared-to-nt-probnp-and-troponin-i
#17
COMPARATIVE STUDY
Ursula Hoffmann, Florian Espeter, Christel Weiß, Parviz Ahmad-Nejad, Siegfried Lang, Martina Brueckmann, Ibrahim Akin, Michael Neumaier, Martin Borggrefe, Michael Behnes
BACKGROUND: To evaluate diagnostic and long-term prognostic values of hFABP compared to NT-proBNP and troponin I (TnI) in patients presenting to the emergency department (ED) suspected of acute heart failure (AHF). METHODS: 401 patients with acute dyspnea or peripheral edema, 122 suffering from AHF, were prospectively enrolled and followed up to 5 years. hFABP combined with NT-proBNP versus NT-proBNP alone was tested for AHF diagnosis. Prognostic value of hFABP versus TnI was evaluated in models predicting all-cause mortality (ACM) and AHF related rehospitalization (AHF-RH) at 1 and 5 years, including 11 conventional risk factors plus NT-proBNP...
June 14, 2015: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/25901102/effects-of-kampo-formulas-on-the-progression-of-hypercholesterolemia-and-fatty-liver-induced-by-high-cholesterol-diet-in-rats
#18
Weibin Qian, Junichi Hasegawa, Satoshi Tsuno, Yusuke Endo, Akiko Matsuda, Norimasa Miura
BACKGROUND: Bofutsushosan is a well known Kampo, traditional Japanese medicine, based on ancient Chinese medicine mainly used in the treatment of hypercholesterolemia in Japan. We selected two Kampo formulas, Boiogito and Keishibukuryogan mainly used in the treatment of hypercholesterolemia in China to compare with Bofutsushosan and cholesterol absorption inhibitor ezetimibe. METHODS: Hypercholesterolemia and fatty liver were induced by high cholesterol (containing 2% cholesterol and 0...
December 2014: Yonago Acta Medica
https://www.readbyqxmd.com/read/25681485/incremental-value-of-heart-type-fatty-acid-binding-protein-in-suspected-acute-myocardial-infarction-early-after-symptom-onset
#19
Andreas W Schoenenberger, Fabio Stallone, Brigitte Walz, Michael Bergner, Raphael Twerenbold, Tobias Reichlin, Bernhard Zogg, Cedric Jaeger, Paul Erne, Christian Mueller
BACKGROUND: The early diagnosis of acute myocardial infarction (AMI) very soon after symptom onset remains a major clinical challenge, even when using high-sensitivity cardiac troponin (hs-cTnT). METHODS AND RESULTS: We investigated the incremental value of heart-type fatty acid-binding protein (hFABP) in a pre-specified subgroup analysis of patients presenting with suspected AMI within 1 h of symptom onset to the emergency department (ED) in a multicentre study...
April 2016: European Heart Journal. Acute Cardiovascular Care
https://www.readbyqxmd.com/read/25637776/high-sensitive-cardiac-troponin-nt-probnp-hfabp-and-copeptin-levels-in-relation-to-glomerular-filtration-rates-and-a-medical-record-of-cardiovascular-disease
#20
Christian Bjurman, Max Petzold, Per Venge, Julia Farbemo, Michael L X Fu, Ola Hammarsten
BACKGROUND: Elevation of cardiac markers in patients with renal dysfunction has not been fully assessed reducing the diagnostic usefulness of these biomarkers. OBJECTIVE: To examine the effects of renal function and a medical record of cardiovascular disease on levels of cardiac biomarkers. METHODS: Serum samples were collected from 489 patients referred for GFR measurement using Cr51-EDTA or iohexol plasma clearance (measured GFR). The cardiac biomarkers Troponin T (hs-cTnT), Troponin I (hsTnI), N-Terminal pro-Brain Natriuretic Peptide (NTproBNP), Copeptin, Human Fatty Acid-Binding Protein (hFABP), as well as the kidney function biomarkers creatinine and cystatin C, were measured...
March 2015: Clinical Biochemistry
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