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https://www.readbyqxmd.com/read/28521436/comparative-study-between-ultrasound-guided-fine-needle-aspiration-cytology-of-axillary-lymph-nodes-and-sentinel-lymph-node-histopathology-in-early-stage-breast-cancer
#1
Lívio Portela Cardoso-Coelho, Rafael Soares Borges, Airlane Pereira Alencar, Larysse Maira Cardoso-Campos-Verdes, João Paulo da Silva-Sampaio, Umbelina Soares Borges, Luiz Henrique Gebrim, Benedito Borges da Silva
The replacement of sentinel lymph node biopsy (SNB) by ultrasound-guided fine-needle aspiration (US-guided FNA) cytology of axillary lymph nodes is controversial, despite the simplicity and reduced cost of the latter. In the present study, US-guided FNA was performed in 27 patients with early-stage breast cancer for comparison with SNB. Data were analyzed by calculation of sample proportions. Tumor subtypes included invasive ductal carcinoma (85%), invasive lobular carcinoma (7%), and tubular and metaplastic carcinoma (4%)...
May 2017: Oncology Letters
https://www.readbyqxmd.com/read/28514220/case-242-radiation-induced-angiosarcoma
#2
Meredith Disharoon, Kamilia F Kozlowski, Jessica M Kaniowski
History In 2004, this woman received a diagnosis of invasive mammillary carcinoma, tubular variant, strongly positive for estrogen and progesterone receptors. Her lesion was found at screening mammography performed at an outside institution when she was 59 years old. She underwent partial mastectomy, with partial axillary node dissection and sentinel node mapping. A 0.6 × 0.5 cm Nottingham grade 1 infiltrating ductal carcinoma was removed from the right upper outer quadrant, margins were free of tumor, and there was no angiolymphatic invasion...
June 2017: Radiology
https://www.readbyqxmd.com/read/28510222/primary-ectopic-breast-cancer-of-the-vulva-treated-with-local-excision-of-the-vulva-and-sentinel-lymph-node-biopsy-a-case-report
#3
Takayuki Ishigaki, Yasuo Toriumi, Ryouko Nosaka, Rei Kudou, Yoshimi Imawari, Makiko Kamio, Hiroko Nogi, Hisashi Shioya, Hiroshi Takeyama
Primary breast cancer fairly infrequently occurs in ectopic breast tissue, and primary ectopic breast cancer of the vulva is particularly rare. Only 26 cases have been published in the English-language literature, and there has been no report of primary breast carcinoma of the vulva in Japan. We report a rare case of primary ectopic breast cancer of the vulva that was treated with local excision of the vulva and sentinel lymph node biopsy (SLNB). The patient was a 72-year-old woman who had noticed a right vulvar tumor 10 years earlier...
December 2017: Surgical Case Reports
https://www.readbyqxmd.com/read/28507456/adjuvant-intraoperative-radiotherapy-for-selected-breast-cancers-in-previously-irradiated-women-evidence-for-excellent-feasibility-and-favorable-outcomes
#4
Gladys Blandino, Marina Guenzi, Liliana Belgioia, Elisabetta Bonzano, Elena Configliacco, Elena Tornari, Francesca Cavagnetto, Davide Bosetti, Alessandra Fozza, Daniele Friedman, Renzo Corvò
BACKGROUND: The present report provides preliminary outcomes with intraoperative radiotherapy delivered to women with breast cancer included in a re-irradiation program. MATERIALS AND METHODS: From October 2010 to April 2014, thirty women were included in a re-irradiation protocol by exploiting IORT technique. The median time between the two irradiations was 10 years (range 3-50). All patients underwent conservative surgery, sentinel lymph node excision and IORT with electron beam delivered by a mobile linear accelerator...
July 2017: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/28503075/imprint-cytology-versus-frozen-section-analysis-for-intraoperative-assessment-of-sentinel-lymph-node-in-breast-cancer
#5
Thalia Petropoulou, Antonia Kapoula, Aikaterini Mastoraki, Aikaterini Politi, Eleni Spanidou-Karvouni, Ioannis Psychogios, Ioannis Vassiliou, Nikolaos Arkadopoulos
INTRODUCTION: Sentinel lymph node (SLN) biopsy is the gold standard for surgical staging of the axilla in breast cancer (BC). Frozen section (FS) remains the most popular means of intraoperative SLN diagnosis. Imprint cytology (IC) has also been suggested as a less expensive and equally accurate alternative to FS. The aim of our study was to perform a direct comparison between IC and FS on the same SLNs of BC cases operated in a single center by the same surgical team. MATERIALS AND METHODS: Into this prospective study we enrolled 60 consecutive patients with histologically proven T1-T3 BC and clinically negative axilla...
2017: Breast Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/28501763/optimal-duration-of-adjuvant-chemotherapy-for-high-risk-node-negative-n-breast-cancer-patients-6-year-results-of-the-prospective-randomised-multicentre-phase-iii-unicancer-pacs-05-trial-ucbg-0106
#6
Pierre Kerbrat, Isabelle Desmoulins, Lise Roca, Christelle Levy, Alain Lortholary, Alain Marre, Rémy Delva, Maria Rios, Patrice Viens, Étienne Brain, Daniel Serin, Magali Edel, Marc Debled, Mario Campone, Marie-Ange Mourret-Reynier, Thomas Bachelot, Marie-Josèphe Foucher-Goudier, Bernard Asselain, Jérôme Lemonnier, Anne-Laure Martin, Henri Roché
PURPOSE: Optimal duration of adjuvant chemotherapy in the treatment of early-stage breast cancer remained to be investigated rigorously for the standard regimens in widespread use in North America (doxorubicin/cyclophosphamide, AC) and Europe (5-fluorouracil/epirubicin/cyclophosphamide, FEC). Whether six cycles of FEC 100 present an advantage, or not, compared with only four cycles was tested directly in a phase III prospective multicentre trial. PATIENTS AND METHODS: Between 2002 and 2006, 1515 women between 18 and 65°years of age, with node negative N(-) high-risk early-stage breast cancer, were included in the study following breast surgery and axillary lymph node dissection or procedure by sentinel node technique...
May 11, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28498821/clinical-significance-of-mskcc-nomogram-on-guiding-the-application-of-touch-imprint-cytology-and-frozen-section-in-intraoperative-assessment-of-breast-sentinel-lymph-nodes
#7
Lisha Sun, Guanglei Chen, Yizhen Zhou, Lei Zhang, Zining Jin, Weiguang Liu, Guangping Wu, Feng Jin, Kai Li, Bo Chen
The widely practiced intra-operative methods for rapid evaluation and detection of sentinel lymph node (SLN) status include frozen section (FS) and touch imprint cytology (TIC). This study optimized the use of TIC and FS in the intra-operative detection of breast SLNs based on the Memorial Sloan Kettering Cancer Center (MSKCC) nomogram. Three hundred forty-two SLNs were removed from 79 patients. SLN metastatic probability was assessed by the MSKCC nomogram. The SLNs underwent intra-operative TIC and FS, as well as routine post-operative paraffin sections (RPSs)...
April 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28492062/intraoperative-injection-of-technetium-99m-sulfur-colloid-for-sentinel-lymph-node-biopsy-in-breast-cancer-patients-a-single-institution-experience
#8
Julian Berrocal, Lawrence Saperstein, Baiba Grube, Nina R Horowitz, Anees B Chagpar, Brigid K Killelea, Donald R Lannin
Background. Most institutions require a patient undergoing sentinel lymph node biopsy to go through nuclear medicine prior to surgery to be injected with radioisotope. This study describes the long-term results using intraoperative injection of radioisotope. Methods. Since late 2002, all patients undergoing a sentinel lymph node biopsy at the Yale-New Haven Breast Center underwent intraoperative injection of technetium-99m sulfur colloid. Endpoints included number of sentinel and nonsentinel lymph nodes obtained and number of positive sentinel and nonsentinel lymph nodes...
2017: Surgery Research and Practice
https://www.readbyqxmd.com/read/28487053/a-novel-less-invasive-approach-for-axillary-staging-after-neoadjuvant-chemotherapy-in-patients-with-axillary-node-positive-breast-cancer-by-combining-radioactive-iodine-seed-localization-in-the-axilla-with-the-sentinel-node-procedure-risas-a-dutch-prospective
#9
Thiemo J A van Nijnatten, Janine M Simons, Marjolein L Smidt, Carmen C van der Pol, Paul J van Diest, Agnes Jager, David van Klaveren, Boen L R Kam, Marc B I Lobbes, Maaike de Boer, Kees Verhoef, Linetta B Koppert, Ernest J T Luiten
BACKGROUND: In 1 of 3 patients with initial lymph node-positive (cN(+)) breast cancer, neoadjuvant chemotherapy (NAC) results in an axillary pathologic complete response (ax-pCR). This urges the need for a less-invasive axillary staging method. Recently introduced less-invasive procedures have been insufficient in accurately identifying ax-pCR. Therefore, we propose a novel less-invasive axillary staging procedure: the Radioactive Iodine Seed localization in the Axilla with the Sentinel node procedure (RISAS), a combination of the procedure of marking axillary lymph nodes with radioactive iodine seeds (MARI) and sentinel lymph node biopsy (SLNB)...
April 19, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28480185/intramammary-sentinel-lymph-node-with-capsular-extravasation-in-breast-cancer
#10
Paulo Roberto De Alcantara Filho, Carla Curi, Camila Souza Guatelli, Cynthia Aparecida B de Toledo Osorio, Stephania Martins Bezerra, Fernando Augusto Soares, Fabiana Baroni Makdissi
Sentinel lymph node biopsy has been developed as the standard of treatment in breast cancer. Status of axillary sentinel lymph node is known to be a significant prognostic factor. Nevertheless, involvement of an intramammary lymph node with metastasis in breast cancer is a rare radiological and clinical presentation, and with extracapsular extravasation even more uncommon. Historically, reported series of patients with intramammary lymph node diagnosed by final histological examination are small in number and clinical significance of metastasis is still unclear...
May 2017: Annals of Surgical Treatment and Research
https://www.readbyqxmd.com/read/28475932/therapeutic-escalation-de-escalation-data-from-15-508-early-breast-cancer-treated-with-upfront-surgery-and-sentinel-lymph-node-biopsy-slnb
#11
Gilles Houvenaeghel, Eric Lambaudie, Monique Cohen, Jean-Marc Classe, Fabien Reyal, Jean-Rémy Garbay, Sylvia Giard, Nicolas Chopin, Alejandra Martinez, Roman Rouzier, Emile Daraï, Pierre Emmanuel Colombo, Charles Coutant, Pierre Gimbergues, Pierre Azuar, Richard Villet, Christine Tunon de Lara, Emmanuel Barranger, Laura Sabiani, Anthony Goncalves
INTRODUCTION: The aim of this study was to examine changes in therapeutic practices for early breast cancer T0-2 N0 managed by upfront surgery and SLNB. POPULATION: Between 1999 and 2012, 15.508 patients were treated. Four periods were determined: 1999-2003, 2004-2006, 2007-2009 and > 2009. Five tumor subtypes were defined according to hormonal receptors (HR) and Her2: Luminal A (HR + Her2- Grade 1-2), Her2 (Her2+ HR-), Triple-negative (HR- Her2-), Luminal B Her2- (HR + Her2- Grade 3), Luminal B Her2+ (HR + HER2+)...
May 2, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28473989/the-noninvasive-treatment-for-sentinel-lymph-node-metastasis-by-photodynamic-therapy-using-phospholipid-polymer-as-a-nanotransporter-of-verteporfin
#12
Kyosuke Shimada, Sachiko Matsuda, Hiromitsu Jinno, Noriaki Kameyama, Tomohiro Konno, Tsunenori Arai, Kazuhiko Ishihara, Yuko Kitagawa
Aim. The usefulness of photodynamic therapy (PDT) for treating sentinel lymph node (SLN) metastasis was evaluated. Materials and Methods. Verteporfin, a hydrophobic photosensitizer, forms a soluble aggregate with poly(2-methacryloyloxyethyl phosphorylcholine-co-n-butyl methacrylate) (PMB). The concentrations of verteporfin were determined by measuring the fluorescence emitted at 700 nm. Seven days after the inoculation of A431 cells at the forearm of BALB/c nude mice, PMB-verteporfin was injected at dorsum manus and 75 J of light energy was delivered for 1 minute...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28467305/breast-sentinel-lymph-node-biopsy-with-imaging-towards-minimally-invasive-surgery
#13
REVIEW
Fredrick Johnson Joseph, Alexander van Oepen, Michael Friebe
Breast sentinel lymph nodes are still commonly assessed through complete lymph node dissections, which is a time-consuming and radical approach because the nodes are difficult to identify. To prevent false diagnosis and achieve accurate results, minimally invasive, image-guided procedures are applied and constantly improved. The purpose of this paper is to present the currently used imaging modalities ultrasound, fluorescence, single-photon emission computed tomography (SPECT), magnetic resonance imaging (MRI) and hybrid imaging methods and comparing their effectiveness for breast sentinel lymph node biopsy...
May 3, 2017: Biomedizinische Technik. Biomedical Engineering
https://www.readbyqxmd.com/read/28458580/lymphoscintigraphy-detecting-alterations-of-upper-limb-lymphatic-flow-following-early-sentinel-lymph-node-biopsy-in-breast-cancer
#14
Almir Jose Sarri, Eduardo Tinois da Silva, Rene Aloisio da Costa Vieira, Katia Hiromoto Koga, Pedro Henrique Moriguchi Cação, Vitor Coca Sarri, Sonia Marta Moriguchi
PURPOSE: To evaluate early variations in lymphatic circulation of the arm pre- and post-sentinel lymph node biopsy (SLNB) and conservative breast surgery by lymphoscintigraphy (LS). PATIENTS AND METHODS: Between 2005 and 2012, 15 patients underwent LS before and after the SLNB (total=30 studies). The pre-SLNB study was considered the control. Early images within twenty minutes (dynamic and static images) and delayed images within ninety minutes of arms and armpits were acquired using a gamma camera...
2017: Breast Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/28454926/predictive-factors-for-nonsentinel-lymph-node-metastasis-in-patients-with-positive-sentinel-lymph-nodes-after-neoadjuvant-chemotherapy-nomogram-for-predicting-nonsentinel-lymph-node-metastasis
#15
Jai Min Ryu, Se Kyung Lee, Ji Young Kim, Jonghan Yu, Seok Won Kim, Jeong Eon Lee, Se Hwan Han, Yong Sik Jung, Seok Jin Nam
INTRODUCTION: Axillary lymph node (ALN) status is an important prognostic factor for breast cancer patients. With increasing numbers of patients undergoing neoadjuvant chemotherapy (NAC), issues concerning sentinel lymph node biopsy (SLNB) after NAC have emerged. PATIENTS AND METHODS: We analyzed the clinicopathologic features and developed a nomogram to predict the possibility of nonsentinel lymph node (NSLN) metastases in patients with positive SLNs after NAC...
April 6, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28439713/personalized-axillary-dissection-the-number-of-excised-lymph-nodes-of-nodal-positive-breast-cancer-patients-has-no-significant-impact-on-relapse-free-and-overall-survival
#16
Florian Ebner, Achim Wöckel, Wolfgang Janni, Rolf Kreienberg, Lukas Schwentner, Manfred Wischnewsky
PURPOSE: Sentinel lymph node (SLN) biopsy has replaced axillary lymph node dissection (ALND) for the staging of clinically node-negative breast cancer patients (BCP), demonstrating equivalent survival to ALND while resulting in reduced morbidity. ALND has remained the standard of care for the majority of BCP with clinical axillary metastases or metastases found on SLN biopsy. More recently, it is debated whether ALND could be avoided not only in SLN-negative BCP but also in selected SLN-positive disease or even in all patients...
April 24, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28433983/pulmonary-metastasis-from-renal-epithelioid-angiomyolipoma-in-the-setting-of-breast-cancer
#17
Eoin MacCraith, Aoife McCarthy, Niall Swan, David Quinlan
A 68-year-old woman presented with visible haematuria. Ultrasonography and triphasic CT revealed a 2.6 cm mass in the lower pole of the left kidney. A biopsy suggested low-grade renal cell carcinoma. Radical nephrectomy was performed and revealed an epithelioid angiomyolipoma. At year 3, the patient developed ductal carcinoma of the right breast and underwent a wide local excision and sentinel lymph node biopsy followed by chemotherapy and radiotherapy. 4 months later, she was noted to have a 1.6 cm nodule in the middle lobe of her right lung...
April 22, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28432480/predictive-value-of-18-f-fdg-pet-ct-for-axillary-lymph-node-metastasis-in-invasive-ductal-breast-cancer
#18
Bong-Il Song, Hae Won Kim, Kyoung Sook Won
BACKGROUND: This study assessed whether primary tumor maximum standardized uptake value (pSUVmax) measured by (18)F-fluoro-2-deoxy-D-glucose ((18)F-FDG) positron emission tomography/computed tomography (PET/CT) could improve the prediction of axillary lymph node (ALN) metastasis in invasive ductal breast cancer (IDC). METHODS: In this study, 128 IDC patients who underwent pretreatment (18)F-FDG PET/CT and surgical resection of primary tumor with sentinel lymph node biopsy, ALN dissection, or both were analyzed...
April 21, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28430742/utility-of-single-photon-emission-tomography-computed-tomography-for-sentinel-lymph-node-localization-in-breast-cancer-patients
#19
Agnieszka Giżewska, Ewa Witkowska-Patena, Sebastian Osiecki, Andrzej Mazurek, Zofia Stembrowicz-Nowakowska, Mirosław Dziuk
OBJECTIVES: Sentinel lymph node (SLN) mapping is currently a routine technique in breast cancer management and preoperative scintigraphic imaging plays a crucial role in the process of SLN detection. The guidelines recommend performing planar acquisition and optional single-photon emission tomography/computed tomography (SPECT/CT) imaging. The aim of this study was to verify whether routine performing of SPECT/CT in addition to planar imaging increases the sensitivity of SLN detection in patients with early-stage breast cancer...
June 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28429197/axillary-micrometastases-and-isolated-tumor-cells-are-not-an-indication-for-post-mastectomy-radiotherapy-in-stage-1-and-2-breast-cancer
#20
Anita Mamtani, Sujata Patil, Michelle Stempel, Monica Morrow
BACKGROUND: Randomized trials demonstrate equivalent locoregional control with sentinel lymph node biopsy (SLNB) or axillary lymph node dissection (ALND) for T1-2 micrometastatic breast cancer, but include few mastectomy patients. Consensus is lacking on indications for post-mastectomy radiotherapy (PMRT) in this population. Herein, we evaluate locoregional recurrence (LRR) in an unselected, modern cohort of T1-2 breast cancer patients with micrometastases or isolated tumor cells (ITCs; N0i+/N1mi) having a mastectomy...
April 20, 2017: Annals of Surgical Oncology
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