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https://www.readbyqxmd.com/read/28191804/does-alternative-and-traditional-wasam-local-cautery-therapy-facilitate-an-early-and-more-extensive-locoregional-metastasis-of-breast-cancer
#1
(no author information available yet)
INTRODUCTION: A large heterogeneous group of unproven remedies exist to treat cancer in both developed and developing countries. Some of these remedies often do more harm than good to the patients. The traditional medicine is the sum total of the knowledge, skills, and practices based on the theories, beliefs, and experiences indigenous to different cultures. The traditional medicine in Oman is based on herbal treatment and skin treatment (massage, Cupping and skin burn "cautery" treatment-known as Wasam or Kaiy)...
September 2016: Gulf Journal of Oncology
https://www.readbyqxmd.com/read/28187209/a-cut-off-of-2150-cytokeratin-19-mrna-copy-number-in-sentinel-lymph-node-may-be-a-powerful-predictor-of-non-sentinel-lymph-node-status-in-breast-cancer-patients
#2
Irene Terrenato, Valerio D'Alicandro, Beatrice Casini, Letizia Perracchio, Francesca Rollo, Laura De Salvo, Simona Di Filippo, Franco Di Filippo, Edoardo Pescarmona, Marcello Maugeri-Saccà, Marcella Mottolese, Simonetta Buglioni
Since 2007, one-step nucleic acid amplification (OSNA) has been used as a diagnostic system for sentinel lymph node (SLN) examination in patients with breast cancer. This study aimed to define a new clinical cut-off of CK19 mRNA copy number based on the calculation of the risk that an axillary lymph node dissection (ALND) will be positive. We analyzed 1529 SLNs from 1140 patients with the OSNA assay and 318 patients with positive SLNs for micrometastasis (250 copies) and macrometastasis (5000 copies) underwent ALND...
2017: PloS One
https://www.readbyqxmd.com/read/28187025/de-novo-upper-extremity-lymphedema-after-elective-hand-surgery-in-breast-cancer-survivors
#3
Heather L Baltzer, Jamison Harvey, Paige M Fox, Steven L Moran
BACKGROUND: The safety of elective hand surgery in breast cancer (BC) survivors is controversial because of concerns of developing upper extremity lymphedema. This study aimed to evaluate the risk of developing lymphedema after elective hand surgery among patients that underwent ipsilateral axillary lymph node dissection (ALND), sentinel lymph node biopsy (SLNB), and/or radiation therapy (RT). METHOD: A retrospective cohort of BC patients treated with ALND, SLNB, and/or RT was identified (1997-2012)...
February 10, 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28185463/-lymphoedema-following-regional-lymph-node-surgery-for-breast-cancer
#4
P Vrtělová, O Coufal, V Fait, L Gabrielová, O Zapletal
BACKGROUND: The treatment of breast cancer is based on the multimodal principle and surgery of regional lymph nodes is an inseparable part of this. Indication criteria are changing constantly folowing advances in other modalities. It is necessary to consider not only the diagnostic or therapeutic benefit but also to take into account adverse effects. Previous studies have demonstrated that axillary dissection (ALND) is burdened by a high frequency of chronic lymphoedema of the arm or chest wall; however, a considerable percentage of patients may also suffer from lymphoedema after sentinel lymph node biopsy (SLNB)...
2017: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://www.readbyqxmd.com/read/28177921/axillary-staging-in-breast-cancer-patients-treated-with-neoadjuvant-chemotherapy-in-two-dutch-phase-iii-studies
#5
Birgit E P J Vriens, Kristien B M I Keymeulen, Judith R Kroep, Ayoub Charehbili, Petronella G Peer, Maaike de Boer, Maureen J B Aarts, Esther M Heuts, Vivianne C G Tjan-Heijnen, The Dutch Breast Cancer Research Group Boog
BACKGROUND: Primary aim of our study was to assess the impact of timing of sentinel node procedure, pre- versus post-neoadjuvant chemotherapy, on final pathologic node-negative rate (pN0) in patients with clinically node-negative (cN0) breast cancer. Secondary endpoint was the usability of the sentinel node procedure in patients with clinically node-positive disease that converted to cN0 after neoadjuvant chemotherapy. PATIENTS AND METHODS: Patients were enrolled in two sequentially conducted Dutch phase III trials, studying the impact of two neoadjuvant chemotherapy schedules and use of zoledronic acid on complete pathologic response rate...
February 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28173818/the-predictive-value-of-methylene-blue-dye-as-a-single-technique-in-breast-cancer-sentinel-node-biopsy-a-study-from-dharmais-cancer-hospital
#6
Bayu Brahma, Rizky Ifandriani Putri, Ramadhan Karsono, Bob Andinata, Walta Gautama, Lenny Sari, Samuel J Haryono
BACKGROUND: Axillary lymph node dissection (ALND) has been the standard treatment of breast cancer axillary staging in Indonesia. The limited facilities of radioisotope tracer and isosulfan or patent blue dye (PBD) have been the major obstacles to perform sentinel node biopsy (SNB) in our country. We studied the application of 1% methylene blue dye (MBD) alone for SNB to overcome the problem. METHODS: This prospective study enrolled 108 patients with suspicious malignant lesions or breast cancer stages I-III...
February 7, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28173790/dcis-and-axillary-nodal-evaluation-compliance-with-national-guidelines
#7
Katrina B Mitchell, Heather Lin, Yu Shen, Alfred Colfry, Henry Kuerer, Simona F Shaitelman, Gildy V Babiera, Isabelle Bedrosian
BACKGROUND: The National Comprehensive Cancer Network (NCCN) and the American Society of Clinical Oncology (ASCO) provide guidelines regarding axillary nodal evaluation in ductal carcinoma in situ (DCIS), but data regarding national compliance with these guidelines remains incomplete. METHODS: We conducted a retrospective review of the National Cancer Data Base (NCDB) analyzing all surgical approaches to axillary evaluation in patients with DCIS. Logistic regression analysis was used to assess the multivariate relationship between patient demographics, clinical characteristics, and probability of axillary evaluation...
February 7, 2017: BMC Surgery
https://www.readbyqxmd.com/read/28168389/can-clinically-node-negative-breast-cancer-patients-with-suspicious-axillary-lymph-nodes-at-ultrasound-but-negative-fine-needle-aspiration-be-approached-as-having-node-negative-disease
#8
Yue Liang, Xiaosong Chen, Weiwei Zhan, David H Garfield, Jiayi Wu, Ou Huang, Yafen Li, Li Zhu, Weiguo Chen, Kunwei Shen
BACKGROUND: Few data exist to elucidate whether patients with a suspicious axillary lymph node (ALN) at ultrasound but a negative fine-needle aspiration result (FNA group) can be managed as having ultrasound node-negative disease (AUN group). This study compared various ALN statuses between the AUN and FNA groups to guide further ALN management. METHODS: Patients who had clinical T1-2N0 breast cancer treated with sentinel lymph node (SLN) biopsy were retrospectively analyzed...
February 6, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28162949/sentinel-node-procedure-obsolete-in-lumpectomy-for-ductal-carcinoma-in-situ
#9
Cathelijne Heymans, James van Bastelaar, Ruben G J Visschers, Yvonne L J Vissers
BACKGROUND: Patients with a preoperative needle-biopsy diagnosis of ductal carcinoma in situ (DCIS) may have an indication for a sentinel lymph node biopsy if invasive carcinoma is found. We investigated how often a positive sentinel node and invasive carcinoma occurred in patients with a preoperative diagnosis of DCIS and whether this influenced the adjuvant regime. MATERIALS AND METHODS: From 2005 to 2014, the records of 240 patients with needle-biopsy diagnosis of DCIS were retrospectively reviewed for postoperative pathology outcomes of the sentinel node and breast, and decisions on adjuvant treatment...
October 19, 2016: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28162210/-surgical-treatment-and-prognosis-of-ductal-carcinoma-in-situ-526-cases-analysis
#10
S J Zhu, X S Chen, J Y Wu, O Huang, J R He, L Zhu, W G Chen, Y F Li, X C Fei, K W Shen
Objective: To evaluate the choice of surgical treatment of ductal carcinoma in situ (DCIS) and its impact on long-term outcomes. Methods: A retrospective analysis of the clinicopathological features and treatment protocol of DCIS patients who underwent surgical treatment in Comprehensive Breast Health Center, Ruijin Hospital, Shanghai Jiaotong University School of Medicine from January 2009 to August 2016 was done. The factors which could affect surgical treatment were analyzed by χ(2) test and Logistic regression...
February 1, 2017: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/28161935/can-we-skip-intraoperative-evaluation-of-sentinel-lymph-nodes-nomogram-predicting-involvement-of-three-or-more-axillary-lymph-nodes-before-breast-cancer-surgery
#11
Soo Kyung Ahn, Min Kyoon Kim, Jongjin Kim, Eunshin Lee, Tae-Kyung Yoo, Han-Byoel Lee, Young Joon Kang, Jisun Kim, Hyeong-Gon Moon, Jung Min Chang, Nariya Cho, Woo Kyung Moon, In Ae Park, Dong-Young Noh, Wonshik Han
Purpose: The American College of Surgeons Oncology Group (ACOSOG) Z0011 trial reported that complete dissection of axillary lymph nodes (ALNs) may not be warranted in women with clinical T1-T2 tumors and one or two involved ALNs who were undergoing lumpectomy plus radiation followed by systemic therapy. The present study was conducted to identify preoperative imaging predictors of ≥3 ALNs. Materials and Methods: The training set consisted of 1917 patients with clinical T1-T2 and node negative invasive breast cancer...
January 25, 2017: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/28153783/feasibility-accuracy-and-prognosis-of-sentinel-lymph-node-biopsy-before-neoadjuvant-therapy-in-breast-cancer-a-prospective-study
#12
Amparo Garcia-Tejedor, Catalina Falo, Cecilia Quetglas, Teresa Soler, Belen Marqueta, Raul Ortega, Miguel Gil-Gil, Sonia Pernas, Eulalia Fernandez-Montolí, Maria J Pla, Anna Guma, Maite Bajen, Ana Benitez, Arantxa Eraso, Miriam Campos, Anna Petit, Jordi Ponce
BACKGROUND AND OBJECTIVE: It remains controversial whether sentinel lymph node biopsy (SLNB) should be performed before or after neoadjuvant therapy (NAT). We aimed to evaluate the feasibility and accuracy of SLNB before NAT at a single institution, and to determine its relation to patient prognosis. METHODS: A prospective study of T1c-T2-T3 N0 breast cancer patients, after ultrasound examination, who underwent SLNB prior to NAT. Overall, disease-specific and disease-free survival were calculated by Kaplan-Meier curves...
January 30, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28152721/the-effect-of-obesity-on-operating-room-or-utilization-in-breast-surgery
#13
Borko Jovanovic, Swati Kulkarni
: 36 Background: More than one-third of adults in the United States are obese. Studies have shown that obesity-related comorbidities increase health care costs, but the effect of obesity on operating room utilization has not been completely evaluated. The purpose of our study was to examine how operative time (OPT) for common procedures in breast surgery is affected by patient weight. We expected that weight affected OPT more so for extensive procedures, such as axillary lymph node dissection (ALND) and mastectomy, than for minimally invasive procedures, such as lumpectomy and sentinel lymph node biopsy (SLNB)...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28145149/axillary-skip-metastases-and-the-false-negative-rate-of-sentinel-lymph-node-biopsy-in-patients-with-breast-cancer-are-related-to-negative-aldh-1-expression-and-ki-67-expression
#14
Woo Gyeong Kim, JungSun Lee
Breast cancer stem cells (CSCs) have been hypothesized to be the driving force behind tumorigenesis and metastasis. In this study, we evaluated the relationships between CSC expressions in primary breast cancers and corresponding metastatic sentinel and nonsentinel lymph nodes (SLNs and NSLNs). The clinical implications of these relationships were also investigated. CSC expressions were evaluated in 167 breast cancer specimens and associated lymph node biopsies (when present). We used double immunohistochemistry of CD44/CD24 and single immunohistochemistry of ALDH-1 on paraffin-embedded breast tissue, SLN, and NSLN specimens...
January 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28140614/preoperative-mri-evaluation-of-axillary-lymph-nodes-in-invasive-ductal-carcinoma-comparison-of-luminal-a-versus-luminal-b-subtypes-in-a-paradigm-using-ki-67-and-receptor-status
#15
Michael J Plaza, Priyanka Handa, Lisa E Esserman
OBJECTIVE: The purpose of this study is to assess whether luminal A versus luminal B molecular subtypes of breast cancer affect the diagnostic utility of preoperative MRI evaluation of the axilla. MATERIALS AND METHODS: This study identified 125 patients who underwent preoperative breast MRI evaluation of tumors classifiable as luminal A or luminal B molecular subtypes between January 2012 and August 2014. The subtypes were classified on the basis of immunohistochemical staining surrogates combining receptor status and the Ki-67 proliferation index...
January 31, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28139362/eight-year-follow-up-result-of-the-otoasor-trial-the-optimal-treatment-of-the-axilla-surgery-or-radiotherapy-after-positive-sentinel-lymph-node-biopsy-in-early-stage-breast-cancer-a-randomized-single-centre-phase-iii-non-inferiority-trial
#16
Á Sávolt, G Péley, C Polgár, N Udvarhelyi, G Rubovszky, E Kovács, B Győrffy, M Kásler, Z Mátrai
INTRODUCTION: The National Institute of Oncology, Budapest conducted a single centre randomized clinical study. The OTOASOR (Optimal Treatment Of the Axilla - Surgery Or Radiotherapy) trial compares completion of axillary lymph node dissection (cALND) to regional nodal irradiation (RNI) in patients with sentinel lymph node metastasis (pN1sn) in stage I-II breast cancer. PATIENTS AND METHODS: Patients with primary invasive breast cancer (cN0 and cT ≤ 3 cm) were randomized before surgery for cALND (standard treatment) or RNI (investigational treatment)...
January 16, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28139361/is-intraoperative-touch-imprint-cytology-indicated-in-the-surgical-treatment-of-early-breast-cancers
#17
Z Horváth, A Paszt, Z Simonka, M Látos, V Oláh, D Nagyszegi, L Kaizer, Z Fejes, S Hamar, E Csörgő, K Ormándi, M Lázár, G Lázár
INTRODUCTION: Intraoperative touch imprint cytology (TIC) of the sentinel lymph node(s) (SLN(s)) in the treatment of breast cancer has significantly reduced the number of axillary block dissections (ABD) required during second surgeries. Based on recent studies, ABD was not considered necessary if the presence of tumor cells/micrometastasis was confirmed in the SLN(s) or in the case of macrometastases in a patient group meeting the inclusion criteria for the ACOSOG Z0011 study. Our aim was to determine the sensitivity and usefulness of TIC with regard to these results...
January 18, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28133344/-a-case-of-sentinel-lymph-node-biopsy-for-male-breast-cancer
#18
Yasumoto Yamasaki, Yasuhiro Yamasaki, Jun Tsuboi
The patient, a 57-year-old man, observed an elastic hard tumor under his left areola. Ultrasonography showed a circular hypoechoic mass that was 1.5 cm in diameter with a moderately indistinct border. Using fine needle aspiration cytology, the tumor was diagnosed as a ductal carcinoma(T1N0M0, stage I ). The patient underwent a mastectomy and a sentinel lymph node biopsy. We omitted radical axillary lymph node dissection because there were no metastases in the sentinel lymph node according to intraoperative frozen section diagnosis...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28133210/-a-case-of-male-hereditary-breast-cancer-involving-a-sentinel-lymph-node-biopsy
#19
Kazuhisa Tokunou, Tatsuhito Yamamoto, Hisato Yamamoto, Ryoji Kamei, Yoshinori Kitamura, Seiichirou Ando
We report a rare case of male hereditary breast cancer in which a sentinel lymph node biopsy was performed. A 62-yearold man was admitted to our hospital because of a palpable tumor in his right breast. Both his younger sister and daughter had had breast cancer. Genetic testing revealed a morbid mutation in the BRCA2 gene. The tumor was palpated to an elastic hard mass and had a clear border in the right DCE area. We performed a core needle biopsy and diagnosed invasive ductal carcinoma, specifically, cT1cN0cM0, cStage I hereditary breast cancer...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28133208/-a-case-of-primary-acinic-cell-carcinoma-acc-of-the-breast
#20
Hiroshi Kawai, Ryoma Sugimoto, Norichika Iga, Hirokuni Ikeda, Ryosuke Yoshida, Naohisa Waki, Masahiro Ishizaki, Hideyuki Nishi, Kazuki Yamashita
A49 -year-old woman presented with a 3.5 cm mass in her right breast. Mammography revealed a lobular mass with poorly defined margins and no microcalcification. Ultrasonography showed a hypoechoic mass with an irregular margin. The tumor was diagnosed as breast carcinoma using a core needle biopsy. The patient underwent a modified radical mastectomy with sentinel lymph node biopsy, and received adjuvant chemotherapy. The tumor consisted of 2 types of carcinoma. The center of the tumor was solid-tubular carcinoma, and the periphery was acinic cell carcinoma(ACC)...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
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