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dendrtic cell and inflammation

Han-Sung Lee, Seok-Hee Chung, Mi-Yeon Song, Sung-Soo Kim, Hyun-Dae Shin, Woo-Jin Shim, Ae-Ri Han, Jong-Soo Lee
AIM OF STUDY: This study was performed to elicit the effectiveness of bee venom (BV), a traditional immunosuppressive Korean acupuncture agent, on the maturation of dendrtic cells (DCs). MATERIALS AND METHODS: Immature dendritic cells (iDCs) were generated from mouse bone marrow cells with GM-CSF. After 10 days of initial differentiation, DCs were activated with lipopolysaccharides (LPS) for another 48h in the presence or absence of BV. Surface molecule analysis, intracytoplasmic staining of cytokines, FITC-conjugated antigen uptake, and transwell migration assays were conducted with iDCs and activated DCs...
November 20, 2008: Journal of Ethnopharmacology
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