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dendrtic cell

Junhua Xie, Shaoping Nie, Qiang Yu, Junyi Yin, Tao Xiong, Deming Gong, Mingyong Xie
The balance of T helper cells 17 (Th17)/regulatory T cells (Treg) plays a key role in maintaining a normal immune response. It is well-known that cyclophosphamide (CTX) applied at high dose often damages the immune system by inhibiting immune cell proliferation. In this study, the immunomodulating effects of Lactobacillus plantarum NCU116 in CTX-induced immunosuppression mice were investigated. Results showed that the levels of cytokines interleukin (IL)-17 and IL-21 were significantly increased after 10 days of treatment with a high dose of NCU116 (46...
February 17, 2016: Journal of Agricultural and Food Chemistry
Fang He, Ke-wei Sun, Jian-ping Peng
OBJECTIVE: To observe the functions of peripheral dendritic cells (DCs) in chronic hepatitis B virus (HBV) infection patients of Gan-depression Pi-deficiency syndrome (GPS) and Gan-Dan damp-heat syndrome (GDS) under different immune states, thus to study the features of the immune expressions of the two syndromes in chronic HBV infection, providing objective evidence for Chinese medicine syndrome typing. METHODS: The 40 chronic HBV patients were randomly assigned to two groups according to the immune state...
November 2011: Chinese Journal of Integrated Traditional and Western Medicine
Ke-qian Zhi, Yan Xu, Wen-hao Ren, Ling Gao, Lu Zhao, Yong Yang, Yin-cheng Zhang
OBJECTIVE: To study the feasibility of dendritic cells (DCs) vaccine on the therapy of tongue carcinoma and find the better way of antigen load. METHODS: The antigen peptides of Tca8113 cells were obtained by acid eluted technique and repetitive freeze thaw method. Separating T cell and inducing dendritic cells were obtained from human peripheral blood monocyte. Divided into three groups: Weak acid elution method antigen group, anti-freeze-thaw method antigen group, and the control group (without tumor antigen)...
April 2010: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
Chun-ling Ma, Kun Yao, Feng Zhou
OBJECTIVE: To investigate the exact mechanism of SARS-CoV pathogenesis at the protein level. METHOD: Under the condition of the establishment of dendrtic cells (DC) culture method, we used recombinant adenovirus to infect mature DC to make clear the development changes in mRNA levels and secreted protein levels of proinflammatory cytokines of IL-1beta, IL-6, IL-8 and TNF-alpha by using RT-PCR and ELISA. RESULT: We found that mRNA levels and secreted protein levels of IL-6 and TNF-alpha in DC had increased gradually after rAd-N infection during first 24 h compared with the control DC infected by rAd-LacZ (P < 0...
December 2008: Chinese Journal of Experimental and Clinical Virology
Han-Sung Lee, Seok-Hee Chung, Mi-Yeon Song, Sung-Soo Kim, Hyun-Dae Shin, Woo-Jin Shim, Ae-Ri Han, Jong-Soo Lee
AIM OF STUDY: This study was performed to elicit the effectiveness of bee venom (BV), a traditional immunosuppressive Korean acupuncture agent, on the maturation of dendrtic cells (DCs). MATERIALS AND METHODS: Immature dendritic cells (iDCs) were generated from mouse bone marrow cells with GM-CSF. After 10 days of initial differentiation, DCs were activated with lipopolysaccharides (LPS) for another 48h in the presence or absence of BV. Surface molecule analysis, intracytoplasmic staining of cytokines, FITC-conjugated antigen uptake, and transwell migration assays were conducted with iDCs and activated DCs...
November 20, 2008: Journal of Ethnopharmacology
Yingzi Cong, Astrid Konrad, Nuzhat Iqbal, Charles O Elson
Intestinal microflora play an important role in the pathogenesis of inflammatory bowel diseases (IBD). Certain probiotic bacteria provide beneficial effects for human health and intervention of IBD. Possible mechanisms underlying these effects are diverse and include many aspects of the interaction of the host with its commensal microflora, with immunological and non-immunological effects. This review paper will focus on the recent progress in the use of probiotics in the treatment of IBD, and discuss the potential immunological mechanisms underlying their effects, such as the modulation of mucosal T cell, B cell, epithelial cell, dendrtic cell, macrophage, nature killer cell, antibody, and cytokine responses...
June 2003: Current Drug Targets. Inflammation and Allergy
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