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https://www.readbyqxmd.com/read/29903682/impact-of-obesity-on-noninvasive-cardiac-hemodynamic-measurement-by-electrical-cardiometry-in-adults-with-aortic-stenosis
#1
Patrick Teefy, Rodrigo Bagur, Chantal Phillips, Kourosh Karimi-Shahri, John Teefy, Raksha Sule, Adam A Dempsey, Kambiz Norozi
OBJECTIVES: There are substantial potential benefits to noninvasive cardiac monitoring methods, such as electrical cardiometry (EC), over more invasive methods, including significantly reduced risk of complications, lower up-front and operational costs, ease of use, and continuous monitoring. To take advantage of these technologies, clinical equivalence to currently established methods must be determined. The authors sought to determine if the noninvasive measurement of cardiac index (CI) by EC was clinically equivalent to thermodilution (TD) in adult patients with aortic stenosis (AS)...
April 26, 2018: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29761059/biodiversity-of-the-great-barrier-reef-how-adequately-is-it-protected
#2
Zoe T Richards, Jon C Day
Background: The Great Barrier Reef (GBR) is the world's most iconic coral reef ecosystem, recognised internationally as a World Heritage Area of outstanding significance. Safeguarding the biodiversity of this universally important reef is a core legislative objective; however, ongoing cumulative impacts including widespread coral bleaching and other detrimental impacts have heightened conservation concerns for the future of the GBR. Methods: Here we review the literature to report on processes threatening species on the GBR, the status of marine biodiversity, and evaluate the extent of species-level monitoring and reporting...
2018: PeerJ
https://www.readbyqxmd.com/read/29695645/non-invasive-measurement-of-cardiac-output-in-children-with-repaired-coarctation-of-the-aorta-using-electrical-cardiometry-compared-to-transthoracic-doppler-echocardiography
#3
Luis Altamirano-Diaz, Eva Welisch, Adam A Dempsey, Teresa Sohee Park, Michael Grattan, Kambiz Norozi
Objective
 To evaluate the equivalence of the ICON® electrical cardiometry (EC) haemodynamic monitor to measure cardiac output (CO) relative to transthoracic Doppler echocardiography (TTE) in paediatric patients with repaired coarctation of the aorta (CoA). 
 
 Approach
 A group of n=28 CoA patients and n=27 matched controls were enrolled. EC and TTE were performed synchronously on each participant and CO measurements compared using linear regression and Bland-Altman analysis...
April 26, 2018: Physiological Measurement
https://www.readbyqxmd.com/read/29624579/seagrass-on-the-brink-decline-of-threatened-seagrass-posidonia-australis-continues-following-protection
#4
Suzanna M Evans, Kingsley J Griffin, Ray A J Blick, Alistair G B Poore, Adriana Vergés
Seagrasses are in decline globally due to sustained pressure from coastal development, water quality declines and the ongoing threat from climate change. The result of this decline has been a change in coastal productivity, a reduction in critical fisheries habitat and increased erosion. Attempts to slow this decline have included legislative protection of habitat and direct restoration efforts. Monitoring the success of these approaches requires tracking changes in the abundance of seagrasses, but such monitoring is frequently conducted at either too coarse a spatial scale, or too infrequently to adequately detect changes within individual meadows...
2018: PloS One
https://www.readbyqxmd.com/read/29447207/demography-of-a-forest-elephant-population
#5
Andrea K Turkalo, Peter H Wrege, George Wittemyer
African forest elephants face severe threats from illegal killing for ivory and bushmeat and habitat conversion. Due to their cryptic nature and inaccessible range, little information on the biology of this species has been collected despite its iconic status. Compiling individual based monitoring data collected over 20 years from the Dzanga Bai population in Central African Republic, we summarize sex and age specific survivorship and female age specific fecundity for a cohort of 1625 individually identified elephants...
2018: PloS One
https://www.readbyqxmd.com/read/29402220/design-of-a-novel-multifunction-decision-support-display-for-anesthesia-care-alertwatch%C3%A2-or
#6
Kevin K Tremper, Jenny J Mace, Jan M Gombert, Theodore T Tremper, Justin F Adams, James P Bagian
BACKGROUND: This paper describes the design of a multifunction alerting display for intraoperative anesthetic care. The design was inspired by the multifunction primary flight display used in modern aviation. RESULTS: The display retrieves live data from multiple sources; the physiologic monitors, the anesthesia information management system, the laboratory values and comorbidities from patient's problem summary list, medical history or history & physical. This information is integrated into a display composed of readily identifiable icons of organ systems, which are color coded to signify normal range, marginal range, abnormal range (by green, yellow, red respectively) and orange outlines for comorbidities/risk factors...
February 5, 2018: BMC Anesthesiology
https://www.readbyqxmd.com/read/29383980/optimizing-anti-vegf-treatment-outcomes-for-patients-with-neovascular-age-related-macular-degeneration
#7
Charles C Wykoff, W Lloyd Clark, Jared S Nielsen, Joel V Brill, Laurence S Greene, Cherilyn L Heggen
BACKGROUND: The introduction of anti-vascular endothelial growth factor (anti-VEGF) drugs to ophthalmology has revolutionized the treatment of neovascular age-related macular degeneration (nAMD). Despite this significant progress, gaps and challenges persist in the diagnosis of nAMD, initiation of treatment, and management of frequent intravitreal injections. Thus, nAMD remains a leading cause of blindness in the United States. OBJECTIVE: To present current knowledge, evidence, and expert perspectives on anti-VEGF therapies in nAMD to support managed care professionals and providers in decision making and collaborative strategies to overcome barriers to optimize anti-VEGF treatment outcomes among nAMD patients...
February 2018: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/29378281/automatic-conflict-monitoring-by-event-related-potentials-could-be-used-to-estimate-visual-acuity-levels
#8
Wenwen Huang, Sinan Liu, Bin Luo, Huanhuan Meng, Mengmeng Ji, Maojuan Li, Xiping Chen, Luyang Tao
Numerous studies have explored the physical attribute features or face perceptions in conflict processing, while complicate gradient conflicts were rarely discussed. The aim of the study was to discuss the relationship between the event-related potential (ERP) component features and different visual acuity levels by using the modified S1-S2 task under non-attention status. Three visual acuity levels were applied, each with four orientations of "E" optotype stimuli randomly presented in the center of the visual field while participants were required to concentrate on listening to stories...
March 15, 2018: Neuroscience
https://www.readbyqxmd.com/read/29361440/international-consensus-icon-on-comprehensive-management-of-the-laryngeal-nerves-risks-during-thyroid-surgery
#9
S Périé, J Santini, H Y Kim, H Dralle, G W Randolph
The laryngeal monitoring of the inferior and superior laryngeal nerves, and the vagus nerve, has advanced for last years, in practice of thyroid and parathyroid surgery. Different methods are used, using direct or indirect laryngeal stimulation and also intermittent or continuous nerve registration. At present time, various recommendations of it in the world use are reported, and availability of the tool used remains a limit in some countries. The aim of this Icon during Ifos 2017 was to share knowledge about laryngeal intraoperative nerve monitoring (LIONM) procedures and to evaluate current practices used to improve the quality of thyroid and parathyroid surgery...
February 2018: European Annals of Otorhinolaryngology, Head and Neck Diseases
https://www.readbyqxmd.com/read/29335514/monitoring-single-cell-gene-regulation-under-dynamically-controllable-conditions-with-integrated-microfluidics-and-software
#10
Matthias Kaiser, Florian Jug, Thomas Julou, Siddharth Deshpande, Thomas Pfohl, Olin K Silander, Gene Myers, Erik van Nimwegen
Much is still not understood about how gene regulatory interactions control cell fate decisions in single cells, in part due to the difficulty of directly observing gene regulatory processes in vivo. We introduce here a novel integrated setup consisting of a microfluidic chip and accompanying analysis software that enable long-term quantitative tracking of growth and gene expression in single cells. The dual-input Mother Machine (DIMM) chip enables controlled and continuous variation of external conditions, allowing direct observation of gene regulatory responses to changing conditions in single cells...
January 15, 2018: Nature Communications
https://www.readbyqxmd.com/read/29283588/do-capuchin-monkeys-sapajus-apella-know-the-contents-of-memory-traces-a-study-of-metamemory-for-compound-stimuli
#11
Saho Takagi, Kazuo Fujita
Whereas evidence has accumulated that nonhuman animals have access to the strength of their memory trace, it is unclear whether such metamemory contains components, as proposed by Hampton (2005). We assessed whether capuchin monkeys could recognize details of memorized items using a delayed matching-to-sample task. We used compound stimuli separable into 2 dimensions, "what" and "where." Two monkeys were trained to memorize both "what" and "where" a sample was and answer both/either "what" and/or "where" the sample was depending on each task after a delay...
February 2018: Journal of Comparative Psychology
https://www.readbyqxmd.com/read/29232405/monitoring-butterflies-using-counts-of-puddling-males-a-case-study-of-the-rajah-brooke-s-birdwing-trogonoptera-brookiana-albescens
#12
Chooi-Khim Phon, Laurence G Kirton, Yusoff Norma-Rashid
The Rajah Brooke's Birdwing, Trogonoptera brookiana, is a large, iconic butterfly that is facing heavy commercial exploitation and habitat loss. Males of some subspecies exhibit puddling behavior. A method of conservation monitoring was developed for subspecies albescens in Ulu Geroh, Peninsular Malaysia, where the males consistently puddle in single-species aggregations at stable geothermal springs, reaching well over 300 individuals when the population is at its highest. Digital photography was used to conduct counts of numbers of males puddling...
2017: PloS One
https://www.readbyqxmd.com/read/29222766/electrical-velocimetry-for-non-invasive-monitoring-of-the-closure-of-the-ductus-arteriosus-in-preterm-infants
#13
COMPARATIVE STUDY
Ana Rodríguez Sánchez de la Blanca, M Sánchez Luna, N González Pacheco, M Arriaga Redondo, N Navarro Patiño
Closure of a patent ductus arteriosus (PDA) in preterm infants modifies cardiac output and induces adaptive changes in the hemodynamic situation. The present study aims to analyze those changes, through a non-invasive cardiac output monitor based on blood electrical velocimetry, in preterm babies. A prospective observational study of preterm infants with a gestational age of less than 28 weeks, and a hemodynamic significant PDA, requires intravenous ibuprofen or surgical closure. All patients were monitored with electrical velocimetry before treatment and through the following 72 h...
February 2018: European Journal of Pediatrics
https://www.readbyqxmd.com/read/28944738/an-industry-update-the-latest-developments-in-therapeutic-delivery
#14
Oliver C Steinbach
The present industry update covers the period 1-30 June 2017, with information sourced from company press releases, regulatory and patent agencies as well as scientific literature. The combination of drug and devices such as improved, safer injectables (see various market reports, companies Adamis and Baxter), patches (Microdermis) and (nano)carriers are moving increasingly from the R&D stage into clinical trials and toward the market. This addresses increased safety and effectiveness requirements, limiting physico-chemical properties of active ingredients, cost-effectiveness and patient comfort through ease of use...
October 2017: Therapeutic Delivery
https://www.readbyqxmd.com/read/28938961/rationale-and-design-of-the-icon-reloaded-study-international-collaborative-of-n-terminal-pro-b-type-natriuretic-peptide-re-evaluation-of-acute-diagnostic-cut-offs-in-the-emergency-department
#15
RANDOMIZED CONTROLLED TRIAL
Hanna Kim Gaggin, Annabel Angela Chen-Tournoux, Robert H Christenson, Gheorghe Doros, Judd Eric Hollander, Phillip David Levy, John Tobias Nagurney, Richard Michael Nowak, Peter S Pang, Darshita Patel, Willam Frank Peacock, Elizabeth Lea Walters, James Louis Januzzi
OBJECTIVES: The objectives were to reassess use of amino-terminal pro B-type natriuretic peptide (NT-proBNP) concentrations for diagnosis and prognosis of acute heart failure (HF) in patients with acute dyspnea. BACKGROUND: NT-proBNP facilitates diagnosis, prognosis, and treatment in patients with suspected or proven acute HF. As demographics of such patients are changing, previous diagnostic NT-proBNP thresholds may need updating. Additionally, value of in-hospital NT-proBNP prognostic monitoring for HF is less understood...
October 2017: American Heart Journal
https://www.readbyqxmd.com/read/28877284/caries-progression-in-non-cavitated-fissures-after-infiltrant-application-a-3-year-follow-up-of-a-randomized-controlled-clinical-trial
#16
Camillo Anauate-Netto, Laurindo Borelli, Ricardo Amore, Vinicius DI Hipólito, Paulo Henrique Perlatti D'Alpino
Objectives: To evaluate the efficacy of a conservative treatment to prevent the progression of caries using an infiltrant on non-cavitated pit and fissures. Material and Methods: This controlled clinical trial selected 23 volunteers with clinically and radiographically non-cavitated occlusal caries among patients presenting a "rather low" to "very high" caries risk. Eighty-six teeth were randomly divided into two experimental groups: teeth receiving a commercial pit-and-fissure sealant (Alpha Seal-DFL) and contralateral teeth receiving Icon infiltrant (DMG)...
July 2017: Journal of Applied Oral Science: Revista FOB
https://www.readbyqxmd.com/read/28671259/transferability-of-microsatellite-markers-in-syagrus-coronata-mart-becc-arecaceae-an-iconic-palm-tree-from-the-brazilian-semiarid-region
#17
R R Simplicio, D G Pereira, A M Waldschmidt
The licuri palm Syagrus coronata plays a key role in the ecology and economy of Brazilian semiarid region. Nonetheless, genetic data about populations of this species are absent even though the intensive and uncontrolled exploitation since colonial periods has threatened the sustainability and viability of licuri populations. Therefore, we attempted to test the efficacy of transferability of microsatellite loci isolated from three palm tree species to S. coronata to analyze the population of this species throughout their range...
June 29, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28631572/endoplasmic-reticulum-stress-could-induce-autophagy-and-apoptosis-and-enhance-chemotherapy-sensitivity-in-human-esophageal-cancer-ec9706-cells-by-mediating-pi3k-akt-mtor-signaling-pathway
#18
Fang Zhou, Yan-Hua Li, Jian-Jun Wang, Jia Pan, Hong Lu
The study was designed to explore the mechanism of tunicamycin-induced endoplasmic reticulum stress in human esophageal cancer EC9706 cells and EC109 cells, as well as its effects on cell autophagy, apoptosis, and chemoresistance. Tunicamycin-induced endoplasmic reticulum stress model was established in EC9706 and EC109 cell lines. Western blotting was employed to detect the expression of endoplasmic reticulum stress iconic protein GRP78. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay was used to evaluate the effect of different cisplatin and tunicamycin concentrations on survival rate of EC9706 cells and EC109 cells...
June 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28598912/cardiac-output-measurements-based-on-the-pulse-wave-transit-time-and-thoracic-impedance-exhibit-limited-agreement-with-thermodilution-method-during-orthotopic-liver-transplantation
#19
COMPARATIVE STUDY
Aurora Magliocca, Emanuele Rezoagli, Thomas Anthony Anderson, Sara Maria Burns, Fumito Ichinose, Hovig Vatche Chitilian
BACKGROUND: Orthotopic liver transplantation (OLT) is characterized by significant intraoperative hemodynamic variability. Accurate and real-time cardiac output (CO) monitoring aids clinical decision making during OLT. The purpose of this study is to compare accuracy, precision, and trending ability of CO estimation obtained noninvasively using pulse wave transit time (estimated continuous cardiac output [esCCO; Nihon Kohden, Tokyo, Japan]) or thoracic bioimpedance (ICON; Osypka Medical GmbH, Berlin, Germany) to thermodilution cardiac output (TDCO) measured with a pulmonary artery catheter...
January 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28534797/transition-icons-for-time-series-visualization-and-exploratory-analysis
#20
Paul V Nickerson, Raheleh Baharloo, Amal A Wanigatunga, Todd M Manini, Patrick J Tighe, Parisa Rashidi
The modern healthcare landscape has seen the rapid emergence of techniques and devices that temporally monitor and record physiological signals. The prevalence of time-series data within the healthcare field necessitates the development of methods that can analyze the data in order to draw meaningful conclusions. Time-series behavior is notoriously difficult to intuitively understand due to its intrinsic high-dimensionality, which is compounded in the case of analyzing groups of time series collected from different patients...
March 2018: IEEE Journal of Biomedical and Health Informatics
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