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Gisela Cristiane Miyamoto, Chung-Wei Christine Lin, Cristina Maria Nunes Cabral, Johanna M van Dongen, Maurits W van Tulder
OBJECTIVE: To investigate the cost-effectiveness of exercise therapy in the treatment of patients with non-specific neck pain and low back pain. DESIGN: Systematic review of economic evaluations. DATA SOURCES: The search was performed in 5 clinical and 3 economic electronic databases. ELIGIBILITY CRITERIA FOR SELECTING STUDIES: We included economic evaluations performed alongside randomised controlled trials. Differences in costs and effects were pooled in a meta-analysis, if possible, and incremental cost-utility ratios (ICUR) were descriptively analysed...
April 20, 2018: British Journal of Sports Medicine
Cristian Eugeniu Boru, Francesco Greco, Piero Giustacchini, Marco Raffaelli, Gianfranco Silecchia
INTRODUCTION: The outcomes of failed laparoscopic sleeve gastrectomies (LSG) converted to laparoscopic standard R-Y gastric bypass (LRYGB) in case of insufficient weight loss (IWL), weight regain (WR), and/or severe gastro-esophageal reflux disease (GERD) are scanty. PURPOSE: To evaluate incidence, indications, and short-term outcomes of LSG conversion to LRYGB in three bariatric centers. METHODS: Patients operated between January 2012 and December 2016 by primary LSG, with mean follow-up of 24 months and converted to LRYGB for IWL, WR, and/or GERD, were retrospectively analyzed for demographics, operative details, perioperative complications, comorbidities evolution, and further WL...
April 20, 2018: Langenbeck's Archives of Surgery
Arne Kienzle, Andrew B Servais, Alexandra B Ysasi, Barry C Gibney, Cristian D Valenzuela, Willi L Wagner, Maximilian Ackermann, Steven J Mentzer
Objectives: The mesothelium, the surface layer of the heart, lung, bowel, liver, and tunica vaginalis, is a complex tissue implicated in organ-specific diseases and regenerative biology; however, the mechanism of mesothelial repair after surgical injury is unknown. Previous observations indicated seeding of denuded mesothelium by free-floating mesothelial cells may contribute to mesothelial healing. In this study, we investigated the prevalence of mesothelial cells in pleural fluid during the 7 days following pulmonary surgery...
2018: Frontiers in Medicine
Guilherme R Teodoro, Aline V L Gontijo, Marcos J Salvador, Márcia H Tanaka, Fernanda L Brighenti, Alberto C B Delbem, Ádina C B Delbem, Cristiane Y Koga-Ito
A promising anti- Candida activity of Buchenavia tomentosa extracts was recently described. In the present work, experiments were carried out to determine the fraction with higher antifungal activity from a B. tomentosa extract. Acetone fraction (AF) was obtained from the aqueous extract from dried leaves (5 min/100°C) and it was the most effective one. Gallic acid (GA) was identified by electrospray ionization mass spectrometry (ESI-MS) and also chosen to perform antifungal tests due to its promising activity on Candida albicans ...
2018: Frontiers in Microbiology
Dahan da Cunha Nascimento, Cristiane Rocha da Silva, Renato Valduga, Bruno Saraiva, Ivo Vieira de Sousa Neto, Amilton Vieira, Silvana Schwerz Funghetto, Alessandro Oliveira Silva, Samuel da Cunha Oliveira, Guilherme Borges Pereira, Jeffrey M Willardson, Jonato Prestes
Purpose: The purpose of the present study was to identify the variability of blood pressure response to a 10-week resistance training (RT) program in hypertensive and normotensive elderly women. Participants and methods: Twenty-seven untrained hypertensive and 12 normotensive elderly women participated in the present study. A whole-body RT program was performed on two nonconsecutive days per week for 10 weeks. The responsiveness of resting systolic blood pressure (SBP) was determined based on the percent decline between the pre- and post-training time points T1 and T4...
2018: Clinical Interventions in Aging
Carlos Milovic, Julio Acosta-Cabronero, José Miguel Pinto, Hendrik Mattern, Marcelo Andia, Sergio Uribe, Cristian Tejos
PURPOSE: Most approaches for quantitative susceptibility mapping (QSM) are based on a forward model approximation that employs a continuous Fourier transform operator to solve a differential equation system. Such formulation, however, is prone to high-frequency aliasing. The aim of this study was to reduce such errors using an alternative dipole kernel formulation based on the discrete Fourier transform and discrete operators. METHODS: The impact of such an approach on forward model calculation and susceptibility inversion was evaluated in contrast to the continuous formulation both with synthetic phantoms and in vivo MRI data...
April 16, 2018: Magnetic Resonance Imaging
Diego Quintanilla-Ahumada, Pedro A Quijón, Jorge M Navarro, José Pulgar, Cristian Duarte
The transfer of seaweeds from subtidal bottoms to nearby intertidal rocky shores is a common but often overlooked phenomenon. Freshly detached seaweeds often represent critical trophic subsidies for herbivores living in upper-shore rocky intertidal areas, such as the marine snail Diloma nigerrima. This species relies on three species of seaweeds for food and displays feeding strategies to deal with a resource that is scarce and at times unpredictable. This study focused on the nutritional quality of freshly detached algae (Durvillaea antarctica, Lessonia spicata and Lessonia trabeculata) and measured Diloma nigerrima's algal consumption rates in trials with and without choice...
2018: PloS One
Ravi Mehta, Patrick Gerardin, Carlos Alexandre Antunes de Brito, Cristiane Nascimento Soares, Maria Lucia Brito Ferreira, Tom Solomon
We performed a systematic review on the neurological complications of chikungunya virus. Such complications are being reported increasingly, owing primarily to the scale of recent epidemics but also to a growing understanding of the virus' neurovirulence. We performed a thorough literature search using PubMed and Scopus databases, summating the data on all published reports of neurological disease associated with chikungunya virus. We appraised the data for each major condition in adults, children, and neonates, as well as evaluating the latest evidence on disease pathogenesis and management strategies...
April 19, 2018: Reviews in Medical Virology
Sakineh Kazemi Noureini, Mitra Kheirabadi, Fatima Masoumi, Farve Khosrogerdi, Younes Zarei, Cristian Suárez-Rozas, Julio Salas-Norambuena, Bruce Kennedy Cassels
Telomerase, the enzyme responsible for cell immortality, is an important target in anti-cancer drug discovery. Boldine, an abundant aporphine alkaloid of Peumus boldus , is known to inhibit telomerase at non-toxic concentrations. Cytotoxicity of N -benzylsecoboldine hydrochloride (BSB), a synthetic derivative of boldine, was determined using the MTT method in MCF7 and MDA-MB231 cells. Aliquots of cell lysates were incubated with various concentrations of BSB in qTRAP (quantitative telomere repeat amplification protocol)-ligand experiments before substrate elongation by telomerase or amplification by hot-start Taq polymerase...
April 19, 2018: International Journal of Molecular Sciences
Roya Zandi, Cristian Micheletti, Rudolf Podgornik
No abstract text is available yet for this article.
April 18, 2018: Journal of Biological Physics
Luziane da C Borges, Raimundo Negrão-Neto, Sônia Pamplona, Luanna Fernandes, Mayra Barros, Enéas Fontes-Júnior, Cristiane Maia, Consuelo Y Yoshioka E Silva, Milton Nascimento da Silva
The aim of this study was to investigate the chemical composition and the antiinflammatory/antinociceptive properties of the hydroalcoholic extract derived from the leaves of Phyllanthus brasiliensis (HEPB) in rodents. A new arylnaphthalene lignan glycoside, 5- O -β-d-glucopyranosyljusticidin B, together with six known lignans, were isolated from HEPB. 1D and 2D NMR experiments and HRMS were used to elucidate the structure of the new compound. HEPB toxicity and antinociceptive activity were evaluated through acute oral toxicity and formalin models in mice, respectively...
April 18, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Peijing Zhang, Zhenna Xiao, Shouyu Wang, Mutian Zhang, Yongkun Wei, Qinglei Hang, Jongchan Kim, Fan Yao, Cristian Rodriguez-Aguayo, Baochau N Ton, Minjung Lee, Yumeng Wang, Zhicheng Zhou, Liyong Zeng, Xiaoyu Hu, Sarah E Lawhon, Ashley N Siverly, Xiaohua Su, Jia Li, Xiaoping Xie, Xuhong Cheng, Liang-Chiu Liu, Hui-Wen Chang, Shu-Fen Chiang, Gabriel Lopez-Berestein, Anil K Sood, Junjie Chen, M James You, Shao-Cong Sun, Han Liang, Yun Huang, Xianbin Yang, Deqiang Sun, Yutong Sun, Mien-Chie Hung, Li Ma
Although EZH2 enzymatic inhibitors have shown antitumor effects in EZH2-mutated lymphoma and ARID1A-mutated ovarian cancer, many cancers do not respond because EZH2 can promote cancer independently of its histone methyltransferase activity. Here we identify ZRANB1 as the EZH2 deubiquitinase. ZRANB1 binds, deubiquitinates, and stabilizes EZH2. Depletion of ZRANB1 in breast cancer cells results in EZH2 destabilization and growth inhibition. Systemic delivery of ZRANB1 small interfering RNA (siRNA) leads to marked antitumor and antimetastatic effects in preclinical models of triple-negative breast cancer (TNBC)...
April 17, 2018: Cell Reports
Thierry Berny, Karen Jansen, Taiane de Azevedo Cardoso, Thaíse Campos Mondin, Ricardo Azevedo da Silva, Luciano Dias de Mattos Souza, Cristian Patrick Zeni, Flavio Kapczinski, Vera Figueiredo
Introduction Biological rhythm is associated with the level of alertness, cognitive performance and mood of the individuals. Its regularity is essential to preserve good health and quality of life. Objective To present the steps for the construction of the scale entitled Biological Rhythm Interview of Assessment in Neuropsychiatry - Kids (BRIAN-K), designed to measure biological rhythm disruptions in Brazilian children and adolescents. Methods Items were developed following the adult version of the scale. Analysis of the psychometric characteristics of the scale was based on the responses of 373 parents/caregivers of school age children (7 and 8 years old)...
March 2018: Trends in Psychiatry and Psychotherapy
Luciana Ramos de Moura, Lilian Machado Torres, Matilde Meire Miranda Cadete, Cristiane de Freitas Cunha
OBJECTIVE: Identifying knowledge about factors associated with health risk behaviors among Brazilian adolescents. METHOD: An integrative review of the literature conducted in the Cochrane, IBECS, LILACS, MEDLINE and SciELO databases in relation to risk behaviors recommended by the Centers for Disease Control and Prevention. RESULTS: Thirty-seven (37) studies were analyzed, with a predominance of risky sexual behavior, tobacco use and violent behavior...
2018: Revista da Escola de Enfermagem da U S P
Paola Vellante, Aldo Carnevale, Cristian D'Ovidio
Intragastric balloon (IGB) therapy is a widely used technique to counter obesity, and it is known to be safe and effective. Although there can be a high rate of side effects following IGB therapy, most are self-healing and they are mainly accommodative in nature. Few cases of Wernicke's syndrome under IGB therapy have been described in the literature, and to the best of our knowledge, none have been fatal. We present here a case of a 51-year-old woman who underwent IGB therapy over 8 months. Late diagnosed Wernicke's syndrome that first appeared as lower limb neuropathy progressively immobilized the patient, until she required bed rest...
2018: Case Reports in Gastrointestinal Medicine
Michael T White, Stephan Karl, Cristian Koepfli, Rhea J Longley, Natalie E Hofmann, Rahel Wampfler, Ingrid Felger, Tom Smith, Wang Nguitragool, Jetsumon Sattabongkot, Leanne Robinson, Azra Ghani, Ivo Mueller
BACKGROUND: In malaria endemic populations, complex patterns of Plasmodium vivax and Plasmodium falciparum blood-stage infection dynamics may be observed. Genotyping samples from longitudinal cohort studies for merozoite surface protein (msp) variants increases the information available in the data, allowing multiple infecting parasite clones in a single individual to be identified. msp genotyped samples from two longitudinal cohorts in Papua New Guinea (PNG) and Thailand were analysed using a statistical model where the times of acquisition and clearance of each clone in every individual were estimated using a process of data augmentation...
April 17, 2018: Malaria Journal
Ana de Sena Cortabitarte, Simone Berkel, Flavia-Bianca Cristian, Christine Fischer, Gudrun A Rappold
BACKGROUND: Mutations in the SHANK genes, which encode postsynaptic scaffolding proteins, have been linked to a spectrum of neurodevelopmental disorders. The SHANK genes and the schizophrenia-associated microRNA-137 show convergence on several levels, as they are both expressed at the synapse, influence neuronal development, and have a strong link to neurodevelopmental and neuropsychiatric disorders like intellectual disability, autism, and schizophrenia. This compiled evidence raised the question if the SHANKs might be targets of miR-137...
April 17, 2018: Journal of Neurodevelopmental Disorders
Cristiane Ps Andrade, Cláudio J Souza, Eduardo Sn Camerini, Isabela S Alves, Hélio C Vital, Matthew Jf Healy, Edson Ramos De Andrade
A radiological dispersive device (RDD) spreads radioactive material, complicates the treatment of physical injuries, raises cancer risk, and induces disproportionate fear. Simulating such an event enables more effective and efficient utilization of the triage and treatment resources of staff, facilities, and space. Fast simulation can give detail on events in progress or future events. The resources for triage and treatment of contaminated trauma victims can differ for pure exposure individuals, while discouraging the "worried well" from presenting in the crisis phase by media announcement would relieve pressure on hospital facilities...
January 1, 2018: Toxicology and Industrial Health
Christian Léon, Darío González-Abradelo, Cristian A Strassert, Jens Müller
Silver nanoclusters (AgNCs) stabilized by double-stranded DNA (dsDNA) are of special interest because the duplex structures provide rigidity and chirality that can be transferred to the metal clusters. We report fluorescent AgNCs obtained from dsDNA templates containing artificial ligand-derived nucleobases. They are compared with fluorescent AgNCs obtained from DNA templates containing C:C mismatches (C, cytosine). Towards this end, the new metal-mediated Im-Ag(I)-C base pair composed of imidazole (Im) and cytosine was introduced into dsDNA and reduced to form AgNCs...
April 17, 2018: Chemistry: a European Journal
Ximena Díaz-Martínez, Fanny Petermann, Carlos Salas Bravo, Alex Garrido-Méndez, María Adela Martínez, Ana María Leiva, Cristian Alvarez, Pedro Valdivia-Moral, María Luisa Zagalaz, Eliana Durán, Ana María Labraña, Felipe Poblete-Valderrama, Carlos Celis-Morales
No abstract text is available yet for this article.
November 2017: Revista Médica de Chile
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