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Maria C Fernandez, Cristian O'Flaherty
STUDY QUESTION: Are all components of the peroxiredoxins (PRDXs) system important to control the levels of reactive oxygen species (ROS) to maintain viability and DNA integrity in spermatozoa? SUMMARY ANSWER: PRDX6 is the primary player of the PRDXs system for maintaining viability and DNA integrity in human spermatozoa. WHAT IS KNOWN ALREADY: Mammalian spermatozoa are sensitive to high levels of ROS and PRDXs are antioxidant enzymes proven to control the levels of ROS generated during sperm capacitation to avoid oxidative damage in the spermatozoon...
June 15, 2018: Human Reproduction
Miguel Santin, Laura Muñoz, Cristian Tebé
No abstract text is available yet for this article.
April 18, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Sergio Bietti, Francesco Basso Basset, David Scarpellini, Alexey Fedorov, Andrea Ballabio, Luca Esposito, Martin Elborg, Takashi Kuroda, Akos Nemcsics, Lajos Toth, Cristian Manzoni, Caterina Vozzi, Stefano Sanguinetti
A hybrid metal-semiconductor nanosystem for the generation of THz radiation, based on the fabrication of GaAs quantum molecules-Ga metal nanoparticles complexes through a self assembly approach, is proposed. The role of the growth parameters, the substrate temperature, the Ga and As flux during the quantum dot molecule fabrication and the metal nanoparticle alignment is discussed. The tuning of the relative positioning of quantum dot molecules and metal nanoparticles is obtained through the careful control of Ga droplet nucleation sites via Ga surface diffusion...
June 18, 2018: Nanotechnology
Cristiane Decat Bergerot, Karen Lynn Clark, Kimlin Tam Ashing, Paulo Gustavo Bergerot, Richard Obenchain, Nazli Dizman, JoAnn Hsu, Errol Philip, Matthew Loscalzo, Sumanta Kumar Pal
OBJECTIVE: Limited research exists examining the biopsychosocial experience of patients diagnosed with metastatic renal cell carcinoma (mRCC), a disease commonly associated with a poor prognosis. The purpose of this study was to describe rates and types of distress in mRCC patients and explore the relationship between distress and overall survival. METHOD: A cohort of 102 patients with mRCC treated at a single institution was assessed by a touch screen-based instrument comprising 22 core items spanning physical, practical, functional, and emotional domains...
June 18, 2018: Palliative & Supportive Care
Radu-Cristian Moldovan, Ede Bodoki, Anne-Catherine Servais, Bezhan Chankvetadze, Jacques Crommen, Radu Oprean, Marianne Fillet
A targeted CE-MS approach was developed for the chiral analysis of biologically relevant amino acids in artificial cerebrospinal fluid (aCSF). In order to achieve chiral resolution, the five amino acids (Ser, Asn, Asp, Gln and Glu) were derivatized with (+)-1-(9-fluorenyl)ethyl chloroformate ((+)-FLEC). The diastereoselectivity was found to be highly dependent on pH for all analytes and the optimized background electrolyte (BGE) consisted of 150 mM acetic acid, adjusted to pH 3.7 with NH4 OH. Furthermore, a reversal of the migration order of Asp derivatives was observed...
June 13, 2018: Journal of Chromatography. A
Rodrigo Ramirez-Campillo, Cristian Alvarez, Antonio Garcìa-Hermoso, Carlos Celis-Morales, Robinson Ramirez-Velez, Paulo Gentil, Mikel Izquierdo
OBJECTIVE: To compare the effects of 12 weeks of high-speed resistance training on functional performance and quality of life in elderly women when using either a traditional-set (TS) or a cluster-set (CS) configuration for inter-set rest. METHODS: Three groups of subjects were formed by block-design randomization as follows: (i) control group (CG, n = 17; age, 66.5 ± 5.4 years); (ii) 12-week high-speed resistance training group under a CS configuration (CSG, n = 15; age, 67...
June 14, 2018: Experimental Gerontology
Juliane Ertl, Melanie Pichlsberger, Alexandru-Cristian Tuca, Paul Wurzer, Jakob Fuchs, Stefan H Geyer, Barbara Maurer-Gesek, Wolfgang J Weninger, Dagmar Pfeiffer, Vladimir Bubalo, Daryousch Parvizi, Lars-Peter Kamolz, Ingrid Lang
OBJECTIVE: Mesenchymal stem/stromal cells derived from human term placentas (PMSCs) are novel therapeutic agents and more topical than ever. Here we evaluated the effects of three types of PMSCs on wound healing in an in vivo mouse model: Amnion-derived MSCs (AMSCs), blood vessel-derived MSCs (BV-MSCs) from the chorionic plate and Wharton's jelly-derived MSCs (WJ-MSCs) from the umbilical cord. METHODS: We topically applied PMSCs onto skin wounds in mice using the dermal substitute Matriderm® as carrier and evaluated wound healing parameters...
May 2018: Placenta
Maria Bindea, Bogdan Rusu, Alexandru Rusu, Monica Trif, Loredana Florina Leopold, Francisc Dulf, Dan Cristian Vodnar
The goal of this research is the investigation of a way to maximize the production of docosahexaenoic acid (DHA) and β-carotene by optimizing the culture conditions of their sources, microalgae Schizochytrium limacinum and fungus Blakeslea trispora respectively, in a fermentation medium. The influencing factors in the fermentation process for producing DHA and β-carotene have proven to be: the concentration of carbon source (different glycerol crude and pure concentrations) for both of them, and in particular temperature for DHA and pH for β-carotene...
June 16, 2018: Microbial Cell Factories
Tim Beausire, Mohamed Faouzi, Cristian Palmiere, Tony Fracasso, Katarzyna Michaud
INTRODUCTION: Ischemic heart disease (IHD) related to atherosclerotic coronary artery disease (CAD) is one of the most prevalent causes of death in Europe. Postmortem evaluation of IHD remains a challenge because of possible non-specific autopsy finding in some autopsy cases, especially in early myocardial ischemia. High-sensitive cardiac troponin T (hs-TnT) is used today in clinical practice as the "gold standard" to diagnose the myocardial ischemia, and might also be applied as an ancillary tool for post-mortem evaluation...
June 4, 2018: Forensic Science International
Catrin Youssif, Monica Cubillos-Rojas, Mònica Comalada, Elisabeth Llonch, Cristian Perna, Nabil Djouder, Angel R Nebreda
The protein kinase p38α plays a key role in cell homeostasis, and p38α signaling in intestinal epithelial cells protects against colitis-induced tumorigenesis. However, little is known on the contribution of p38α signaling in intestinal stromal cells. Here, we show that myeloid cell-specific downregulation of p38α protects mice against inflammation-associated colon tumorigenesis. The reduced tumorigenesis correlates with impaired detection in the colon of crucial chemokines for immune cell recruitment. We identify insulin-like growth factor-1 (IGF-1) as a novel mediator of the p38α pathway in macrophages...
June 14, 2018: EMBO Molecular Medicine
Fadwa Cazala, Robert Suchting, Cristian P Zeni, Isabelle E Bauer, Benson Mwangi, Mon-Ju Wu, Ives Cavalcante Passos, Danielle E Spiker, Giovanna B Zunta-Soares, Jair C Soares
Sodium valproate (VPA) has well-established neuroprotective effects and is recommended as treatment in bipolar disorder patients. The neural effects of VPA in pediatric bipolar disorder (PBD) have yet to be established. This preliminary study explored the effects of VPA on brain structure in PBD. Fourteen PBD patients (10 males; mean = 13.43 ± 3.05 years old) underwent a structural MRI before and after a 6-week VPA treatment period. Bayesian linear mixed modeling explored seven brain region volumes as a function of dichotomous pre/post time...
June 6, 2018: Psychiatry research. Neuroimaging
Cristian Román-Palacios, Jose Tavera, María Del Rosario Castañeda
Whereas most of the studies that discuss the evolutionary divergence of Anolis lizards have dated the clade's crown group in between 31-64 Ma, a single study has recovered a significantly older age for the same node (87 Ma). These differences also entail notable consequences on the preferred biogeographical hypothesis for the whole clade. Here we analyze a total of seven dating strategies by combining three calibration sources in independent BEAST runs to infer the most probable divergence timing for anole lizards (a mitochondrial rate for ND2 gene, the Anolis dominicanus fossil, and a group of fossils assigned to the Priscagamines, Iguanines, and Idontosaurus clades)...
June 12, 2018: Molecular Phylogenetics and Evolution
Alynne Carvalho-Galvão, Blessing Ogunlade, Jiaxi Xu, Cristiane R A Silva-Alves, Leônidas G Mendes-Júnior, Drielle D Guimarães, Josiane C Cruz, Thyago M Queiroz, Camille M Balarini, Valdir A Braga, Catalin M Filipeanu, Eric Lazartigues, Maria S França-Silva
TRV027 is a biased agonist for the Angiotensin (Ang)-II type 1 receptor (AT1 R), able to recruit ß-arrestin 2 independently of G-proteins activation. ß-arrestin activation in the central nervous system (CNS) was suggested to oppose the effects of Ang-II. This study evaluates the effect of central infusion of TRV027 on arterial pressure (AP), autonomic function, baroreflex sensitivity and peripheral vascular reactivity. Spontaneously hypertensive (SH) and Wistar Kyoto (WKY) rats were treated with TRV027 for 14 days (20 ng/hour) delivered to the lateral ventricle via osmotic minipumps...
June 14, 2018: Clinical Science (1979-)
María Jesús Álvarez-Holzapfel, Juan Ángel Aibar Durán, Sonia Brió Sanagustin, Cristian de Quintana-Schmidt
No abstract text is available yet for this article.
June 11, 2018: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
Emilio Rodriguez-Ruiz, Victoria Guerra Martín, Cristian Abelairas-Gómez, Fátima Sampedro Vidal, Candela Gómez González, Roberto Barcala-Furelos, Antonio Rodríguez-Nuñez
OBJECTIVE: To compare the quality of chest compressions performed according to the classical technique (MT) versus a new technique (NM) (compression with 2thumbs with closed fists) in an infant manikin. DESIGN: A controlled, randomized cross-over study was carried out in professionals assisting pediatric patients. SETTING: A University Hospital with a Pediatric ICU in the north of Spain. PARTICIPANTS: Residents and nurses in Pediatrics who had completed a basic and an advanced pediatric cardiopulmonary resuscitation course...
June 11, 2018: Medicina Intensiva
Cristian Osgnach, Pietro Enrico di Prampero
A previous approach to estimate the time course of instantaneous metabolic power and O2 consumption in team sports has been updated to assess also energy expenditure against air resistance and to identify walking and running separately. Whole match energy expenditure turned out ≈14% smaller than previously obtained, the fraction against the air resistance amounting to ≈2% of the total. Estimated net O2 consumption and overall energy expenditure are fairly close to those measured by means of a portable metabolic cart; the average difference, after a 45 min exercise period of variable intensity and mode, amounting to ≈10%...
June 14, 2018: International Journal of Sports Medicine
Pietro Enrico di Prampero, Cristian Osgnach
Team sports are characterised by frequent episodes of accelerated/decelerated running. The corresponding energy cost can be estimated on the basis of the biomechanical equivalence between accelerated/decelerated running on flat terrain and constant speed running uphill/downhill. This approach allows one to: (i) estimate the time course of the instantaneous metabolic power requirement of any given player and (ii) infer therefrom the overall energy expenditure of any given time window of a soccer drill or match...
June 14, 2018: International Journal of Sports Medicine
Gilson Soares do Nascimento, Renato Polimeni Constantin, Eduardo Hideo Gilglioni, Cristiane Vizioli de Castro Ghizoni, Adelar Bracht, Karina Sayuri Utsunomiya, Nair Seiko Yamamoto, Emy Luiza Ishii-Iwamoto, Jorgete Constantin, Rodrigo Polimeni Constantin
No abstract text is available yet for this article.
June 11, 2018: Toxicology Letters
Eduardo Tibirica, Amanda Barcelos, Cristiane Lamas
This article represents data associated with a prior publication from our research group, under the title: Evaluation of microvascular endothelial function and capillary density in patients with infective endocarditis using laser speckle contrast imaging and video-capillaroscopy [1]. Patients with definite infective endocarditis, under stable clinical conditions, were prospectively included. The clinical and laboratory features are presented for each of them in raw form. Microvascular reactivity was evaluated using a laser speckle contrast imaging (LSCI) system with a laser wavelength of 785 nm...
June 2018: Data in Brief
Paola Rey-Suárez, Cristian Acosta, Uday Torres, Mónica Saldarriaga-Córdoba, Bruno Lomonte, Vitelbina Núñez
L-amino acid oxidases (LAAOs) are ubiquitous enzymes in nature. Bioactivities described for these enzymes include apoptosis induction, edema formation, induction or inhibition of platelet aggregation, as well as antiviral, antiparasite, and antibacterial actions. With over 80 species, Micrurus snakes are the representatives of the Elapidae family in the New World. Although LAAOs in Micrurus venoms have been predicted by venom gland transcriptomic studies and detected in proteomic studies, no enzymes of this kind have been previously purified from their venoms...
2018: PeerJ
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