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https://www.readbyqxmd.com/read/28650703/program-implementation-of-option-b%C3%A2-at-a-president-s-emergency-plan-for-aids-relief-supported-hiv-clinic-improves-clinical-indicators-but-not-retention-in-care-in-mbarara-uganda
#1
Kathleen Miller, Winnie Muyindike, Lynn T Matthews, Michael Kanyesigye, Mark J Siedner
2013 WHO guidelines for prevention of mother to child transmission recommend combination antiretroviral therapy (ART) for all pregnant women, regardless of CD4 count (Option B/B+). We conducted a retrospective analysis of data from a government-operated HIV clinic in Mbarara, Uganda before and after implementation of Option B+ to assess the impact on retention in care. We limited our analysis to women not on ART at the time of their first reported pregnancy with CD4 count >350. We fit regression models to estimate relationships between calendar period (Option A vs...
June 26, 2017: AIDS Patient Care and STDs
https://www.readbyqxmd.com/read/28638192/treatment-effect-of-antipsychotics-in-combination-with-horticultural-therapy-on-patients-with-schizophrenia-a-randomized-double-blind-placebo-controlled-study
#2
Shunhong Zhu, Hengjing Wan, Zhide Lu, Huiping Wu, Qun Zhang, Xiaoqiong Qian, Chenyu Ye
BACKGROUND: As a newly developed treatment method for schizophrenia, horticultural therapy is gaining more attention. However, there is as of now little research investigating this topic as well as a general lack of studies adopting into standard treatment plans. AIMS: Investigate treatment effect of horticultural therapy on patients with schizophrenia and its possibility of standardized application in psychiatric hospitals. METHODS: 110 patients with schizophrenia who met the inclusion criteria and provided informed consent were selected from the rehabilitation ward of the Minhang District Mental Health Center from September 2015 to December 2015...
August 25, 2016: Shanghai Archives of Psychiatry
https://www.readbyqxmd.com/read/28632435/relative-effects-of-plasma-fibrinogen-concentrate-and-factor-xiii-on-rotem-coagulation-profiles-in-an-in-vitro-model-of-massive-transfusion-in-trauma
#3
David E Schmidt, Märit Halmin, Agneta Wikman, Anders Östlund, Anna Ågren
Massive traumatic haemorrhage is aggravated through the development of trauma-induced coagulopathy, which is managed by plasma transfusion and/or fibrinogen concentrate administration. It is yet unclear whether these treatments are equally potent in ensuring adequate haemostasis, and whether additional factor XIII (FXIII) administration provides further benefits. In this study, we compared ROTEM whole blood coagulation profiles after experimental massive transfusion with different transfusion regimens in an in vitro model of dilution- and transfusion-related coagulopathy...
June 20, 2017: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/28618105/factors-influencing-medication-adherence-in-patients-with-gout-a-descriptive-correlational-study
#4
Xin Hui Jasmine Chua, Siriwan Lim, Fui Ping Lim, Yee Nah Anita Lim, Hong-Gu He, Gim Gee Teng
AIMS AND OBJECTIVES: To examine the factors influencing adherence to urate-lowering therapy in patients with gout in Singapore. BACKGROUND: Gout is the most common type of chronic inflammatory arthritis. Urate-lowering therapy (ULT) is used to treat gout by reducing serum uric acid levels. However, adherence to ULT among patients remains poor. To date, there have been no available studies based on a conceptual framework that examined factors influencing medication adherence in patients with gout...
June 15, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28616423/the-relationship-between-sexual-dysfunction-and-quality-of-marital-relationship-in-genital-and-breast-cancers-women
#5
Fariba Fahami, Soheila Mohamadirizi, Mitra Savabi
INTRODUCTION: The concept of sexual dysfunction is dysfunction in desire and emotional - social that it is Impact on the sexual response cycle and can cause stress and interpersonal difficulties. Quality of marital relationship is one of the important factors predicting sexual function disorders, which varies among different cancers. The purpose of this study is to determine the relationship between sexual dysfunction and quality of marital relationship in genital and breast cancers in women...
2017: Journal of Education and Health Promotion
https://www.readbyqxmd.com/read/28592821/development-of-a-3d-angiogenesis-model-to-study-tumour-endothelial-cell-interactions-and-the-effects-of-anti-angiogenic-drugs
#6
Arno Amann, Marit Zwierzina, Stefan Koeck, Gabriele Gamerith, Elisabeth Pechriggl, Julia M Huber, Edith Lorenz, Jens M Kelm, Wolfgang Hilbe, Heinz Zwierzina, Johann Kern
The tumour microenvironment and tumour angiogenesis play a critical role in the development and therapy of many cancers, but in vitro models reflecting these circumstances are rare. In this study, we describe the development of a novel tri-culture model, using non-small cell lung cancer (NSCLC) cell lines (A549 and Colo699) in combination with a fibroblast cell line (SV 80) and two different endothelial cell lines in a hanging drop technology. Endothelial cells aggregated either in small colonies in Colo699 containing microtissues or in tube like structures mainly in the stromal compartment of microtissues containing A549...
June 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28591713/nomogram-predicts-survival-benefit-from-preoperative-radiotherapy-for-non-metastatic-breast-cancer-a-seer-based-study
#7
Jianjun Liu, Mingxue Su, Shikai Hong, Hong Gao, Xucai Zheng, Shengying Wang
BACKGROUND: To estimate survival in non-metastatic breast cancer patients who failed to achieve a pathological complete response (pCR) more effectively, we combined the clinicpathological characteristics after preoperative radiation therapy (pRT) and established a novel nomogram. MATERIALS AND METHODS: Using the Surveillance, Epidemiology, and End Results (SEER) database, we identified 2,545 non-metastatic breast cancer patients who underwent pRT between 1998 and 2013...
May 18, 2017: Oncotarget
https://www.readbyqxmd.com/read/28591161/health-related-quality-of-life-among-military-hiv-patients-on-antiretroviral-therapy
#8
Leonard Emuren, Seth Welles, Alison A Evans, Marcia Polansky, Jason F Okulicz, Grace Macalino, Brian K Agan
OBJECTIVE: The aims of this study were: (i) to determine the factors associated with HRQOL at baseline in our cohort, and (ii) to evaluate if there are differences in baseline HRQOL measures by antiretroviral treatment. METHODS: The Short Form 36 (SF-36) was administered between 2006 and 2010 among members of the United States HIV Natural History Study cohort (NHS), and participants who completed the SF-36 were included in the study. Physical component summary (PCS) and mental component summary (MCS) scores were computed based on standard algorithms...
2017: PloS One
https://www.readbyqxmd.com/read/28562812/insulin-therapy-waste-produced-in-the-households-of-people-with-diabetes-monitored-in-primary-care
#9
Gilmara Holanda da Cunha, Raiza Verônica Almeida Barbosa, Marina Soares Monteiro Fontenele, Maria Amanda Correia Lima, Katia Barbosa Franco, Francisco Vagnaldo Fechine
Objective: To analyze the insulin therapy waste disposal produced in the households of people with diabetes mellitus (DM). Method: Cross-sectional study with 105 Primary Care patients. Socio-demographic and clinical variables and insulin therapy practice were analyzed through the absolute and relative frequencies, Fisher's exact test and prevalence ratio (PR). Results: The association between types of insulin (60.0%), administered with a disposable syringe attached to a needle (80...
May 2017: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/28552815/leisure-time-physical-activity-and-leukocyte-telomere-length-among-older-women
#10
Aladdin H Shadyab, Michael J LaMonte, Charles Kooperberg, Alexander P Reiner, Cara L Carty, Todd M Manini, Lifang Hou, Chongzhi Di, Caroline A Macera, Linda C Gallo, Richard A Shaffer, Sonia Jain, Andrea Z LaCroix
BACKGROUND: Shortened leukocyte telomere length (LTL), a purported marker of cellular aging, is associated with morbidity and mortality. However, the association of physical activity, a modifiable lifestyle behavior, with LTL has not been adequately studied among older adults. METHODS: In this cross-sectional study, we examined associations of various intensity levels of leisure-time physical activity with LTL among 1476 older white and African American women from the Women's Health Initiative Objective Physical Activity and Cardiovascular Health study...
September 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28539677/fatigue-and-sleep-quality-in-rheumatoid-arthritis-patients-during-hospital-admission
#11
Paulina Szady, Grażyna Bączyk, Katarzyna Kozłowska
OBJECTIVES: Rheumatoid arthritis (RA) is a systemic disease of connective tissue characterised by chronic course with periods of exacerbation and remission. Even in the early stages of the disease patients report the occurrence of fatigue and sleep disorders. Reduced sleep quality and chronic fatigue are common among patients with rheumatoid arthritis. The aim of the research was to evaluate the severity of fatigue and sleep quality assessment among patients hospitalised with rheumatoid arthritis and to determine the relation between the level of symptoms of fatigue and sleep quality and variables such as: age, gender, disease duration, marital status, applied pharmacological treatment, and pain intensity...
2017: Reumatologia
https://www.readbyqxmd.com/read/28520674/relationship-stability-after-traumatic-brain-injury-among-veterans-and-service-members-a-va-tbi-model-systems-study
#12
Lillian Flores Stevens, Yanna Lapis, Xinyu Tang, Angelle M Sander, Laura E Dreer, Flora M Hammond, Jeffrey S Kreutzer, Therese M OʼNeil-Pirozzi, Risa Nakase-Richardson
OBJECTIVE: To explore stability of relationships and predictors of change in relationship status 2 years following TBI/polytrauma. SETTING: Five Department of Veterans Affairs Polytrauma Rehabilitation Centers (VA PRCs). PARTICIPANTS: A total of 357 active duty service members and Veterans enrolled in the Veterans Affairs Polytrauma Rehabilitation Centers Traumatic Brain Injury Model Systems database with complete marital status information at 2 years postinjury...
May 17, 2017: Journal of Head Trauma Rehabilitation
https://www.readbyqxmd.com/read/28515548/culturally-relevant-family-therapy-practice-with-parents-of-children-and-adolescents
#13
Tania Roy, A Thirumoorthy, R Parthasarathy
BACKGROUND: India is diverse in culture, with multiple aspects that may not match with the Western societal picture. Hence, it has often been seen that therapists encounter unique aspects of therapy that is faced during actual practice, which is never written in any textbook or research papers. Substantial information is present through both outcome (efficacy and effectiveness) studies and process research, but it has very little impact of actual Marital and Family Therapy (MFT) practice...
March 2017: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/28507809/t-cell-therapy-targeting-a-public-neoantigen-in-microsatellite-instable-colon-cancer-reduces-in-vivo-tumor-growth
#14
Else M Inderberg, Sébastien Wälchli, Marit R Myhre, Sissel Trachsel, Hilde Almåsbak, Gunnar Kvalheim, Gustav Gaudernack
T-cell receptor (TCR) transfer is an attractive strategy to increase the number of cancer-specific T cells in adoptive cell therapy. However, recent clinical and pre-clinical findings indicate that careful consideration of the target antigen is required to limit the risk of off-target toxicity. Directing T cells against mutated proteins such as frequently occurring frameshift mutations may thus be a safer alternative to tumor-associated self-antigens. Furthermore, such frameshift mutations result in novel polypeptides allowing selection of TCRs from the non-tolerant T-cell repertoire circumventing the problem of low affinity TCRs due to central tolerance...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/28492085/self-managing-hiv-aids-cultural-competence-and-health-among-women-in-nairobi-kenya
#15
Toni Copeland
Despite recent efforts to supply antiretroviral therapy, many in Africa are not receiving medication, instead relying on self-management in their attempts to remain healthy. In Kenya, the majority of those infected are women who are below the extreme poverty level. Building on research demonstrating a link between knowledge of HIV/AIDS management and the length of time HIV-positive women have lived in Nairobi, this article uses a cognitive anthropological approach that conceives of culture as shared models and explores the relationship between how well women know a cultural model of self-managing HIV/AIDS and health among women who are not receiving biomedical treatment...
May 11, 2017: Anthropology & Medicine
https://www.readbyqxmd.com/read/28487444/the-longitudinal-transcriptional-response-to-neoadjuvant-chemotherapy-with-and-without-bevacizumab-in-breast-cancer
#16
Laxmi Silwal-Pandit, Silje Nord, Hedda von der Lippe Gythfeldt, Elen K Møller, Thomas Fleischer, Einar Rødland, Marit Krohn, Elin Borgen, Øystein Garred, Tone Olsen, Phuong Vu, Helle Skjerven, Anne Fangberget, Marit M Holmen, Ellen Schlichting, Elisabeth Wille, Mette Nordberg Stokke, Hans Kristian Moen Vollan, Vessela N Kristensen, Anita Langerød, Steinar Lundgren, Erik A Wist, Bjørn Naume, Ole Christian Lingjerde, Anne-Lise Borresen-Dale, Olav Engebraaten
Chemotherapy induced alterations to gene expression are due to transcriptional reprogramming of tumor cells or subclonal adaptations to treatment. The effect on whole-transcriptome mRNA expression was investigated in a randomized phase II clinical trial to assess the effect of neoadjuvant chemotherapy with the addition of bevacizumab. <br />Experimental Design: Tumor biopsies and whole-transcriptome mRNA profiles were obtained at three fixed time points with 66 patients in each arm.  Altogether, 358 specimens from 132 patients were available, representing the transcriptional state before treatment start, at 12 weeks and after treatment (25 weeks)...
May 9, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28484965/the-protective-role-of-small-heat-shock-proteins-in-cardiac-diseases-key-role-in-atrial-fibrillation
#17
Xu Hu, Denise M S Van Marion, Marit Wiersma, Deli Zhang, Bianca J J M Brundel
Atrial fibrillation (AF) is the most common tachyarrhythmia which is associated with increased morbidity and mortality. AF usually progresses from a self-terminating paroxysmal to persistent disease. It has been recognized that AF progression is driven by structural remodeling of cardiomyocytes, which results in electrical and contractile dysfunction of the atria. We recently showed that structural remodeling is rooted in derailment of proteostasis, i.e., homeostasis of protein production, function, and degradation...
July 2017: Cell Stress & Chaperones
https://www.readbyqxmd.com/read/28479461/superior-lower-extremity-vein-graft-bypass-patency-among-married-patients-with-peripheral-arterial-disease
#18
Emily Lagergren, Kelly Kempe, Timothy E Craven, Susan T Kornegay, Justin B Hurie, Nitin Garg, Gabriela Velazquez Ramirez, Matthew S Edwards, Matthew A Corriere
INTRODUCTION: Outcomes disparities associated with lower extremity bypass (LEB) for peripheral arterial disease (PAD) have been identified but are poorly understood. Marital status may affect outcomes through factors related to health risk behaviors, adherence, and access to care but has not been characterized as a predictor of surgical outcomes and is often omitted from administrative datasets. We evaluated associations between marital status and vein graft patency following LEB using multivariable models adjusting for established risk factors...
May 4, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28473671/prevalence-of-menopausal-symptoms-its-effect-to-quality-of-life-among-malaysian-women-and-their-treatment-seeking-behaviour
#19
B Abdullah, B Moize, B A Ismail, M Zamri, N F Mohd Nasir
INTRODUCTION: This study aimed to determine the prevalence of menopausal symptoms, its effect to the quality of life and their treatment seeking behaviour in a multiracial community in Malaysia. METHODS: This is a cross-sectional study involving postmenopausal women in Klang Valley, Malaysia. Data was obtained by face-to-face interview using standardised questionnaires on sociodemographic data, Menopause Rating Scale questionnaire, effect to quality of life and treatment sought...
April 2017: Medical Journal of Malaysia
https://www.readbyqxmd.com/read/28472987/use-of-complementary-and-alternative-medicine-by-patients-with-end-stage-renal-disease-on-haemodialysis-in-trinidad-a-descriptive-study
#20
Mandreker Bahall
BACKGROUND: Despite the paucity of scientific evidence, complementary and alternative medicine (CAM) is widely used for the prevention and treatment of illness, holistic care, and counteracting the adverse effects of conventional medicine (CM). This study investigates the use of CAM by patients with end-stage renal disease (ESRD) on haemodialysis. METHODS: This quantitative study was conducted from November 1, 2014 to December 31, 2014 in the haemodialysis unit at San Fernando General Hospital (San Fernando, Trinidad)...
May 4, 2017: BMC Complementary and Alternative Medicine
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