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https://www.readbyqxmd.com/read/27906029/trends-in-clinical-characteristics-and-outcomes-of-pre-art-care-at-a-large-hiv-clinic-in-nairobi-kenya-a-retrospective-cohort-study
#1
Jared O Mecha, Elizabeth N Kubo, Lucy W Nganga, Peter N Muiruri, Lilian N Njagi, Immaculate N Mutisya, Justine J Odionyi, Syokau C Ilovi, Mary Wambui, Christopher Githu, Richard Ngethe, Elizabeth M Obimbo, Zipporah W Ngumi
BACKGROUND: The success of antiretroviral therapy in resource-scarce settings is an illustration that complex healthcare interventions can be successfully delivered even in fragile health systems. Documenting the success factors in the scale-up of HIV care and treatment in resource constrained settings will enable health systems to prepare for changing population health needs. This study describes changing demographic and clinical characteristics of adult pre-ART cohorts, and identifies predictors of pre-ART attrition at a large urban HIV clinic in Nairobi, Kenya...
November 14, 2016: AIDS Research and Therapy
https://www.readbyqxmd.com/read/27906025/nutritional-status-and-its-effect-on-treatment-outcome-among-hiv-infected-clients-receiving-haart-in-ethiopia-a-cohort-study
#2
Sadikalmahdi Hussen, Tefera Belachew, Nezif Hussien
PURPOSES: The aim of this study was to determine the effects of nutritional status at the start of highly active anti-retroviral therapy on treatment outcomes among HIV/AIDS patients taking HAART at Jimma University Specialized Hospital. METHODS: We performed a retrospective cohort study involving 340 adults who started highly active anti-retroviral therapy. The patients have been clinically followed for 2 years. Data were extracted from paper based medical charts by trained data collectors from January 30 to February 28, 2014 using data collection format...
September 22, 2016: AIDS Research and Therapy
https://www.readbyqxmd.com/read/27895697/trends-in-clinical-characteristics-and-outcomes-of-pre-art-care-at-a-large-hiv-clinic-in-nairobi-kenya-a-retrospective-cohort-study
#3
Jared O Mecha, Elizabeth N Kubo, Lucy W Nganga, Peter N Muiruri, Lilian N Njagi, Immaculate N Mutisya, Justine J Odionyi, Syokau C Ilovi, Mary Wambui, Christopher Githu, Richard Ngethe, Elizabeth M Obimbo, Zipporah W Ngumi
BACKGROUND: The success of antiretroviral therapy in resource-scarce settings is an illustration that complex healthcare interventions can be successfully delivered even in fragile health systems. Documenting the success factors in the scale-up of HIV care and treatment in resource constrained settings will enable health systems to prepare for changing population health needs. This study describes changing demographic and clinical characteristics of adult pre-ART cohorts, and identifies predictors of pre-ART attrition at a large urban HIV clinic in Nairobi, Kenya...
2016: AIDS Research and Therapy
https://www.readbyqxmd.com/read/27893843/comparative-effectiveness-of-smoking-cessation-medications-a-national-prospective-cohort-from-taiwan
#4
Po-Yin Chang, Po-Ching Lo, Hui-Chin Chang, Kuang-Chieh Hsueh, Yi-Wen Tsai
BACKGROUND AND OBJECTIVE: Relative effectiveness of smoking cessation medications-varenicline, bupropion and nicotine replacement therapy (NRT)-remains unclear among smokers in real-world settings. Evidence in females and smokers with light/moderate nicotine dependence is particularly insufficient. This study compared the effectiveness of varenicline, bupropion or NRT gum relative to NRT patch, in achieving abstinence among recent quitters. METHODS: In a national smoking cessation program in Taiwan (2012-2015), a cohort of 11,968 participants received varenicline (n = 5,052), bupropion (n = 823), NRT gum (n = 1944) or NRT patch (n = 4,149)...
2016: PloS One
https://www.readbyqxmd.com/read/27862285/does-travel-time-to-a-radiation-facility-impact-patient-decision-making-regarding-treatment-for-prostate-cancer-a-study-of-the-new-hampshire-state-cancer-registry
#5
Fady Ghali, Maria Celaya, Michael Laviolette, Johann Ingimarsson, Heather Carlos, Judy Rees, Elias Hyams
PURPOSE: We sought to determine whether further distance from a radiation center is associated with lower utilization of external beam radiation therapy (XRT). METHODS: We retrospectively identified patients with a new diagnosis of localized prostate cancer (CaP) within the New Hampshire State Cancer Registry from 2004 to 2011. Patients were categorized by age, D'Amico risk category, year of treatment, marital status, season of diagnosis, urban/rural residence, and driving time to the nearest radiation facility...
November 11, 2016: Journal of Rural Health
https://www.readbyqxmd.com/read/27799754/quality-of-life-of-women-with-breast-cancer-undergoing-radiotherapy-using-the-functional-assessment-of-chronic-illness-therapy-fatigue-questionnaire
#6
Marta Muszalik, Małgorzata Kołucka-Pluta, Kornelia Kędziora-Kornatowska, Joanna Robaczewska
OBJECTIVE: Breast cancer is one of the most common cancers in women, particularly among older women. This illness along with its treatment has a great impact on a woman's subjective opinion of her quality of life and functioning in everyday life. The aim of this research was to assess the quality of life in women undergoing radiotherapy for the treatment of breast cancer. PATIENTS AND METHODS: The research was carried out in 120 patients with breast cancer undergoing radiotherapy in the Oncological Center in Bydgoszcz, Poland...
2016: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/27798199/predictors-of-atherosclerotic-events-in-patients-on-haemodialysis-post-hoc-analyses-from-the-aurora-study
#7
Marit D Solbu, Geir Mjøen, Patrick B Mark, Hallvard Holdaas, Bengt Fellström, Roland E Schmieder, Faiez Zannad, William G Herrington, Alan G Jardine
BACKGROUND: Patients on haemodialysis (HD) are at high risk for cardiovascular events, but heart failure and sudden death are more common than atherosclerotic events. The A Study to Evaluate the Use of Rosuvastatinin in Subjects on Regular Hemodialysis: An Assessment of Survival and Cardiovascular Events (AURORA) trial was designed to assess the effect of rosuvastatin on myocardial infarction and death from any cardiac cause in 2773 HD patients. We studied predictors of the atherosclerotic cardiovascular events in AURORA...
October 17, 2016: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/27784209/systematic-review-and-meta-analysis-of-flibanserin-s-effects-and-adverse-events-in-women-with-hypoactive-sexual-desire-disorder
#8
Amirhossein Sahebkar, Seyed Hassan Saadat, Yunes Panahi, Ali Kabir, Khaled Rahmani, Milad Hosseinialhashemi
The efficacy and safety of flibanserin in the treatment of Hypoactive Sexual Desire Disorder (HSDD) is controversial. We reviewed existing evidence on the efficacy and safety of flibanserin in treating HSDD, and performed a meta-analysis of reported effects. Literature search was performed on PubMed, Scopus, and Cochrane library to find all trials on the efficacy of flibanserin in HSDD. Meta-analysis was performed using fixed- and random-effects models. Egger's test and "trim and fill" methods were used for the assessment of publication bias and imputation of potentially missing studies, respectively...
October 25, 2016: Current Drug Metabolism
https://www.readbyqxmd.com/read/27780311/initiation-of-and-adherence-to-tamoxifen-and-aromatase-inhibitor-therapy-among-elderly-women-with-ductal-carcinoma-in-situ
#9
Hui Zhao, Nainan Hei, Yiling Wu, Winston Chan, Xiudong Lei, Carrie Cameron, Shine Chang, Mariana Chavez-MacGregor, Sharon H Giordano
BACKGROUND: The National Surgical Adjuvant Breast and Bowel Project B35 and International Breast Cancer Intervention Studies II Ductal Carcinoma In Situ trials showed similar treatment effects of anastrozole and tamoxifen in reducing cancer recurrence risk among ductal carcinoma in situ (DCIS) patients. Studies have shown low levels of hormone therapy drug initiation for DCIS patients, but the current body of literature lacks information on the 5-year adherence rates for these drugs from population-based studies...
October 25, 2016: Cancer
https://www.readbyqxmd.com/read/27760087/cultural-issues-in-menopause-an-exploratory-qualitative-study-of-macedonian-women-in-australia
#10
Anita Strezova, Sheila O'Neill, Cathy O'Callaghan, Astrid Perry, Jinzhu Liu, John Eden
OBJECTIVE: This study explored the attitudes to, and experience of, menopause among Macedonian women living in Australia, including attitudes and responses to hormone therapy (HT) and complementary therapies, as well as related psycho-sexual, relationship and other midlife issues. METHODS: Using qualitative methodology, the study was based on seven unstructured, nondirective group discussions. Natural social groups were recruited, meeting wherever each group felt most at home...
October 10, 2016: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/27759822/clinical-and-sociodemographic-variables-associated-with-diabetes-related-distress-in-patients-with-type-2-diabetes-mellitus
#11
Flávia Cristina Zanchetta, Danilo Donizetti Trevisan, Priscila Peruzzo Apolinario, Juliana Bastoni da Silva, Maria Helena de Melo Lima
Objective: To evaluate the relation between diabetes-related distress and the clinical and sociodemographic characteristics of type 2 diabetes mellitus patients. Methods: A cross-sectional study based on a secondary analysis of data collected at a specialized care outpatient center in Brazil. Participants completed a questionnaire on sociodemographic and clinical characteristics and the Brazilian version of the Diabetes Distress Scale (B-DDS). Results: About 31% of the 130 eligible patients reported diabetes distress, and the mean B-DDS score was 2...
July 2016: Einstein
https://www.readbyqxmd.com/read/27756795/socioeconomic-inequalities-in-statin-adherence-under-universal-coverage-does-sex-matter
#12
Emma Aarnio, Janne Martikainen, Aaron N Winn, Risto Huupponen, Jussi Vahtera, Maarit J Korhonen
BACKGROUND: Previous research shows that low socioeconomic position (SEP; especially low income) is associated with statin nonadherence. We investigated the relationship between SEP and statin adherence in a country with universal coverage using group-based trajectory modeling in addition to the proportion of days covered. METHODS AND RESULTS: Using data from Finnish healthcare registers, we identified 116 846 individuals, aged 45 to 75 years, who initiated statin therapy for primary prevention of cardiovascular disease...
October 18, 2016: Circulation. Cardiovascular Quality and Outcomes
https://www.readbyqxmd.com/read/27751307/awareness-treatment-adherence-and-risk-predictors-of-uncontrolled-hypertension-at-a-tertiary-care-teaching-hospital-in-western-india
#13
Rahul Choudhary, Shashi Mohan Sharma, Vimla Kumari, Dinesh Gautam
INTRODUCTION: Hypertension still remains poorly controlled. RESULT: Adequate BP control was achieved in 37.4% of patients and significant attributes for poor control were BMI, marital status, literacy, socioeconomic status, smoking, medication adherence, absence of side effects, number of drugs, number of years on drug therapy and co-morbid conditions.
September 2016: Indian Heart Journal
https://www.readbyqxmd.com/read/27751179/use-of-a-risk-scoring-tool-to-identify-higher-risk-hiv-1-serodiscordant-couples-for-an-antiretroviral-based-hiv-1-prevention-intervention
#14
Elizabeth M Irungu, Renee Heffron, Nelly Mugo, Kenneth Ngure, Elly Katabira, Nulu Bulya, Elizabeth Bukusi, Josephine Odoyo, Stephen Asiimwe, Edna Tindimwebwa, Connie Celum, Jared M Baeten
BACKGROUND: Antiretroviral therapy (ART) and pre-exposure prophylaxis (PrEP) reduce HIV-1 transmission within heterosexual HIV-1 serodiscordant couples. Prioritizing couples at highest HIV-1 transmission risk for ART and PrEP would maximize impact and minimize costs. METHODS: The Partners Demonstration Project is an open-label, delivery study of integrated PrEP and ART for HIV-1 prevention among high risk HIV-1 serodiscordant couples in Kenya and Uganda. We evaluated the feasibility of using a validated risk score that weighs a combination of easily measurable factors (age, children, marital status, male circumcision status, condom use, plasma HIV-1 levels) to identify couples at highest risk for HIV-1 transmission for enrollment...
October 17, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27748030/the-effect-of-central-nervous-system-involvement-and-irradiation-in-childhood-acute-lymphoblastic-leukemia-lessons-from-the-nopho-all-92-and-all-2000-protocols
#15
Mervi Taskinen, Trausti Oskarsson, Mette Levinsen, Matteo Bottai, Marit Hellebostad, Olafur Gisli Jonsson, Päivi Lähteenmäki, Kjeld Schmiegelow, Mats Heyman
BACKGROUND: Central nervous system irradiation (CNS-RT) has played a central role in the cure of acute lymphoblastic leukemia (ALL), but due to the risk of long-term toxicity, it is now considered a less-favorable method of CNS-directed therapy. PROCEDURES: Retrospectively, we estimated the effect of CNS involvement and CNS-RT on events and overall survival (OS) in 835 children treated for high-risk ALL in the Nordic Society of Paediatric Haematology and Oncology (NOPHO) ALL-92 and ALL-2000 trials...
October 17, 2016: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/27741292/risk-factor-associated-with-negative-spouse-hiv-seroconversion-among-sero-different-couples-a-nested-case-control-retrospective-survey-study-in-30-counties-in-rural-china
#16
Houlin Tang, Zunyou Wu, Yurong Mao, Javier Cepeda, Jamie Morano
BACKGROUND: Antiretroviral therapy (ART) and condom use have been proven to reduce the risk of sexual transmission of human immunodeficiency virus (HIV) among HIV sero-different couples, but its full implementation remains a challenge. This study aims to assess HIV seroconversion rate of HIV-negative spouse and its associated risk factors among HIV sero-different couples in rural China. METHODS: An open cohort of HIV sero-different couples enrolled in 30 counties in China between October 1, 2010, and September 30, 2012, and followed-up to December 31, 2012, was constructed retrospectively...
2016: PloS One
https://www.readbyqxmd.com/read/27721640/age-of-menopause-and-determinants-of-menopause-age-a-pan-india-survey-by-ims
#17
Maninder Ahuja
INTRODUCTION: Age of menopause is a very important biomarker of not only the loss of fertility but also an increased risk for various mid-life diseases and problems. Many of these diseases can be prevented by timely intervention of lifestyle modification, menopausal hormone therapy, or other supplementations such as calcium, Vitamin D, and micronutrients. In India age of menopause is less than our counterparts in the Western world. This means that the fertility potential of Indian women starts compromising early, so we need to start with the preventive measures much early...
July 2016: Journal of Mid-life Health
https://www.readbyqxmd.com/read/27711084/he4-is-a-novel-tissue-marker-for-therapy-response-and-progestin-resistance-in-medium-and-low-risk-endometrial-hyperplasia
#18
Anne Ørbo, Marit Arnes, Lena Myreng Lyså, Christer Borgfeldt, Bjørn Straume
No abstract text is available yet for this article.
October 6, 2016: British Journal of Cancer
https://www.readbyqxmd.com/read/27709752/background-factors-associated-with-problem-avoidance-behavior-in-healthy-partners-of-breast-cancer-patients
#19
Mariko Shiozaki, Makiko Sanjo, Kei Hirai
OBJECTIVE: We evaluated avoidance behaviors of healthy partners of breast cancer patients and sought to (1) describe men's perception of their own avoidance behavior and (2) identify the background factors associated with such behavior. METHODS: An Internet-based survey was conducted, and analysis was performed on the responses of 368 male spouses of female breast cancer patients. RESULTS: Thirty to forty percent of spouses had some type of problem avoidance behavior toward their wives...
October 5, 2016: Psycho-oncology
https://www.readbyqxmd.com/read/27703335/evaluation-of-factors-associated-with-psychiatric-patient-dropout-at-a-university-outpatient-clinic-in-japan
#20
Atsumi Minamisawa, Jin Narumoto, Isao Yokota, Kenji Fukui
BACKGROUND: Patient dropout from treatment can lead to a deterioration in clinical condition, thereby increasing the need for more intensive therapy that incurs substantial social and economic losses. The aim of this study was to identify factors related to psychiatric patient dropout at a university outpatient clinic in Japan. METHODS: We retrospectively examined the medical charts of new psychiatric patients who were diagnosed with either a mood disorder (International Classification of Diseases, 10th revision, code: F3) or an anxiety disorder (F4) in the outpatient clinic at Kyoto Prefectural University of Medicine Hospital in Kyoto, Japan, between April 2010 and March 2013...
2016: Patient Preference and Adherence
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