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https://www.readbyqxmd.com/read/28790861/assessment-of-quality-of-life-in-patients-undergoing-hemodialysis-using-whoqol-bref-questionnaire-a-multicenter-study
#1
Utsav Joshi, Roshan Subedi, Prakash Poudel, Prajwol Ram Ghimire, Sagar Panta, Mahesh Raj Sigdel
BACKGROUND: Assessment of quality of life (QOL) of patients with end-stage renal disease has become increasingly important, both in order to evaluate the influence of the disease on patients and the type of renal replacement therapy they require. Therefore, in this study, we aimed to assess QOL in patients undergoing hemodialysis and evaluated the effects of various sociodemographic factors affecting QOL of such patients in Nepal. METHODS: A cross-sectional study was conducted among 150 patients with chronic kidney disease undergoing hemodialysis at two major centers in Nepal...
2017: International Journal of Nephrology and Renovascular Disease
https://www.readbyqxmd.com/read/28782125/dyadic-supervision-evaluation-an-actor-partner-relational-model
#2
Adrian Avila, Brian Distelberg, Ana Estrada, Lauren Foster, Mary Moline, Douglas Huenergardt
This article contributes to research practices in marital and family therapy, specifically the dyadic and development over time in clinical supervision, and describes and applies methodological strategies to develop measurements congruent with the systemic and developmental principles of the field. This project evaluates the psychometric properties of the dyadic supervision evaluation (DSE) in terms of measurement equivalence and causality. A structural equation analysis is conducted utilizing the actor-partner interdependent model resulting in a goodness of fit...
August 7, 2017: Journal of Marital and Family Therapy
https://www.readbyqxmd.com/read/28777690/development-and-validation-of-nomograms-predictive-of-overall-and-progression-free-survival-in-patients-with-oropharyngeal-cancer
#3
Carole Fakhry, Qiang Zhang, Phuc Felix Nguyen-Tân, David I Rosenthal, Randal S Weber, Louise Lambert, Andy M Trotti, William L Barrett, Wade L Thorstad, Christopher U Jones, Sue S Yom, Stuart J Wong, John A Ridge, Shyam S D Rao, James A Bonner, Eric Vigneault, David Raben, Mahesh R Kudrimoti, Jonathan Harris, Quynh-Thu Le, Maura L Gillison
Purpose Treatment of oropharyngeal squamous cell carcinoma (OPSCC) is evolving toward risk-based modification of therapeutic intensity, which requires patient-specific estimates of overall survival (OS) and progression-free survival (PFS). Methods To develop and validate nomograms for OS and PFS, we used a derivation cohort of 493 patients with OPSCC with known p16 tumor status (surrogate of human papillomavirus) and cigarette smoking history (pack-years) randomly assigned to clinical trials using platinum-based chemoradiotherapy (NRG Oncology Radiation Therapy Oncology Group [RTOG] 0129 and 0522)...
August 4, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28766493/evaluation-of-the-safety-and-immunogenicity-of-subcutaneous-hx575-epoetin-alfa-in-the-treatment-of-anemia-associated-with-chronic-kidney-disease-in-predialysis-and-dialysis-patients%C3%A2
#4
Nicole Casadevall, Vladimir Dobronravov, Kai-Uwe Eckardt, Sehsuvar Ertürk, Liliya Martynyuk, Susanne Schmitt, Gregor Schaffar, Anita Rudy, Andriy Krendyukov, Marité Ode
AIM: To assess the safety and immunogenicity of subcutaneous (SC) HX575 (epoetin-α) in dialysis- and nondialysis-dependent adult patients with chronic kidney disease (CKD). METHODS: Open-label, single-arm, multicenter study in patients (n = 416) from Germany, Italy, Poland, Romania, Russia, Turkey, and Ukraine. RESULTS: Mean (standard deviation (SD)) age was 52.3 (15.8) years, all patients were Caucasian, and similar proportions were male/female...
August 2, 2017: Clinical Nephrology
https://www.readbyqxmd.com/read/28762775/diagnostic-experience-of-patients-with-fibromyalgia-a-meta-ethnography
#5
Anne Marit Mengshoel, Julius Sim, Birgitte Ahlsen, Sue Madden
Objective To examine how individuals experience the process and consequences of receiving a diagnosis of fibromyalgia syndrome. Methods A systematic literature search of qualitative studies up to May 2016 was performed. Twenty-eight reports including information on patients' diagnostic experiences were subjected to an interpretive analysis in accordance with the principles of meta-ethnography. Results Years were normally spent consulting specialists in an attempt to confirm the reality of symptoms and make sense of the illness...
January 1, 2017: Chronic Illness
https://www.readbyqxmd.com/read/28755541/vaccines-targeting-helper-t-cells-for-cancer-immunotherapy
#6
REVIEW
Marit Melssen, Craig L Slingluff
There are compelling arguments for designing cancer vaccines specifically to induce CD4(+) helper T cell responses. Recent studies highlight the crucial role of proliferating, activated effector memory Th1 CD4(+) T cells in effective antitumor immunity and reveal that CD4(+) T cells induce more durable immune-mediated tumor control than CD8(+) T cells. CD4(+) T cells promote antitumor immunity by numerous mechanisms including enhancing antigen presentation, co-stimulation, T cell homing, T cell activation, and effector function...
July 26, 2017: Current Opinion in Immunology
https://www.readbyqxmd.com/read/28754166/male-reproductive-health-challenges-appraisal-of-wives-coping-strategies
#7
Emmanuel O Amoo, Adekunbi K Omideyi, Theophilus O Fadayomi, Mofoluwake P Ajayi, Gbolahan A Oni, Adenike E Idowu
BACKGROUND: Systematic studies on the association between men's sexual dysfunction (low sexual desire, ejaculation disorders, erectile dysfunctions, genital ulcers, testicular disorders, prostate cancer or sexually transmitted infections) and marital conflict are emerging. However, the coping strategies adopted by wives in such circumstances are not commonly reported in the literature. Male sexual functioning is vital to the marital relationship, lack of it can result in intolerable cohabitation or relationship breakdown, and could also cause infertility, infidelity, and arouse stigma in Nigeria...
July 28, 2017: Reproductive Health
https://www.readbyqxmd.com/read/28750025/hiv-drug-resistance-in-hiv-positive-individuals-under-antiretroviral-treatment-in-shandong-province-china
#8
Bin Lin, Xiaoguang Sun, Shengli Su, Cuixia Lv, Xiaofei Zhang, Lin Lin, Rui Wang, Jihua Fu, Dianmin Kang
The efficacy of antiretroviral drugs is limited by the development of drug resistance. Therefore, it is important to examine HIV drug resistance following the nationwide implementation of drug resistance testing in China since 2009. We conducted drug resistance testing in patients who were already on or new to HIV antiretroviral therapy (ART) in Shandong Province, China, from 2011 to 2013, and grouped them based on the presence or absence of drug resistance to determine the effects of age, gender, ethnicity, marital status, educational level, route of transmission and treatment status on drug resistance...
2017: PloS One
https://www.readbyqxmd.com/read/28746573/quality-of-life-socioeconomic-and-clinical-factors-and-physical-exercise-in-persons-living-with-hiv-aids
#9
Rafaela Catherine da Silva Cunha de Medeiros, Jason Azevedo de Medeiros, Tatiane Andreza Lima da Silva, Ricardo Dias de Andrade, Danielle Coutinho de Medeiros, Juliany de Souza Araújo, Antônio Manuel Gouveia de Oliveira, Marcos Aurélio de Albuquerque Costa, Paulo Moreira Silva Dantas
OBJECTIVE: To analyze whether socioeconomic and clinical aspects and the aspects of healthy life habits are associated with the quality of life of persons living with HIV/AIDS. METHODS: This is a cross-sectional exploratory quantitative research, with 227 persons living with HIV/AIDS, treated at two hospitals of reference between April 2012 and June 2014. We used structured questionnaires to assess socioeconomic aspects (gender, age, education level, marital status, race, socioeconomic status, dependents on family income, employment relationship), clinical parameters (time of disease diagnosis, use and time of medication, CD4 T-cell count, and viral load), and practice of physical exercise...
July 20, 2017: Revista de Saúde Pública
https://www.readbyqxmd.com/read/28742454/lenalidomide-maintenance-after-autologous-stem-cell-transplantation-in-newly-diagnosed-multiple-myeloma-a-meta-analysis
#10
Philip L McCarthy, Sarah A Holstein, Maria Teresa Petrucci, Paul G Richardson, Cyrille Hulin, Patrizia Tosi, Sara Bringhen, Pellegrino Musto, Kenneth C Anderson, Denis Caillot, Francesca Gay, Philippe Moreau, Gerald Marit, Sin-Ho Jung, Zhinuan Yu, Benjamin Winograd, Robert D Knight, Antonio Palumbo, Michel Attal
Purpose Lenalidomide maintenance therapy after autologous stem-cell transplantation (ASCT) demonstrated prolonged progression-free survival (PFS) versus placebo or observation in several randomized controlled trials (RCTs) of patients with newly diagnosed multiple myeloma (NDMM). All studies had PFS as the primary end point, and none were powered for overall survival (OS) as a primary end point. Thus, a meta-analysis was conducted to better understand the impact of lenalidomide maintenance in this setting. Patients and Methods The meta-analysis was conducted using primary-source patient-level data and documentation from three RCTs (Cancer and Leukemia Group B 100104, Gruppo Italiano Malattie Ematologiche dell'Adulto RV-MM-PI-209, and Intergroupe Francophone du Myélome 2005-02) that met the following prespecified inclusion criteria: an RCT in patients with NDMM receiving ASCT followed by lenalidomide maintenance versus placebo or observation with patient-level data available and achieved database lock for primary efficacy analysis...
July 25, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28737990/cost-effectiveness-of-novel-agents-in-medicare-patients-with-multiple-myeloma-findings-from-a-u-s-payer-s-perspective
#11
Ying Chen, David R Lairson, Wenyaw Chan, Jinhai Huo, Xianglin L Du
BACKGROUND: Since multiple myeloma (MM) incurs a substantial economic burden in care management, more and more discussion has been generated in recent years about the costs of novel antimyeloma drugs and their associated value. Because of these costs, economic assessment that quantifies value of care over the long-term is essential. OBJECTIVE: To determine the cost-effectiveness (measured as cost per life-year saved) of front-line novel agent-based therapy use among a cohort of elderly patients with MM in a real-world setting...
August 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28728348/effect-of-antiretroviral-therapy-art-on-change-in-fertility-intentions-of-hiv-positive-women-in-addis-ababa-ethiopia-a-prospective-follow-up-study
#12
Hussen Mekonnen
Objectives: The study aimed to assess change in fertility intentions 12 months after ART initiation among HIV positive women in Addis Ababa, Ethiopia. Methods: Institution based follow up study was conducted, among 360 HIV positive women in Addis Ababa; from June 2012 to October 2013. Logistic regression model was used to assess the influence socio-demographic, reproductive health and clinical characteristics on the change in fertility intention of women. Results: Overall, 41...
July 16, 2017: Epidemiology and Health
https://www.readbyqxmd.com/read/28727897/the-course-of-fear-of-cancer-recurrence-different-patterns-by-age-in-breast-cancer-survivors
#13
Daniëlle E J Starreveld, Sabine E Markovitz, Gerard van Breukelen, Madelon L Peters
OBJECTIVE: To examine the time course and predictors of fear of cancer recurrence (FCR) in breast cancer survivors over a period of 18 months after initial surgery. METHODS: Breast cancer patients (n = 267) were followed until 18 months after primary breast surgery. Shortly after surgery, participants completed the Life Orientation Test-Revised (LOT-R) to measure optimism and the Concerns about Recurrence Scale (CARS) to measure FCR. Mixed regression analysis was performed with age, optimism, marital status, education, type of surgery, with or without lymphectomy, chemotherapy, hormonal therapy, or radiotherapy, time since surgery and all interactions with time as predictors of FCR...
July 20, 2017: Psycho-oncology
https://www.readbyqxmd.com/read/28725492/role-of-spousal-involvement-in-continuous-positive-airway-pressure-cpap-adherence-in-patients-with-obstructive-sleep-apnea-osa
#14
Salma Batool-Anwar, Carol M Baldwin, Shira Fass, Stuart F Quan
INTRODUCTION: Little is known about the impact of spousal involvement on continuous positive airway pressure (CPAP) adherence. The aim of this study was to determine whether spouse involvement affects adherence with CPAP therapy, and how this association varies with gender. METHODS: 194 subjects recruited from Apnea Positive Pressure Long Term Efficacy Study (APPLES) completed the Dyadic Adjustment Scale (DAS). The majority of participants were Caucasian (83%), and males (73%), with mean age of 56 years, mean BMI of 31 kg/m(2)...
May 2017: Southwest Journal of Pulmonary & Critical Care
https://www.readbyqxmd.com/read/28702506/prenatal-depression-risk-factors-developmental-effects-and-interventions-a-review
#15
Tiffany Field
This narrative review based on a literature search in PubMed and PsycInfo on the two terms prenatal and antenatal depression includes empirical studies, reviews and meta-analyses that have been published during the last 5 years on risk factors, developmental effects and interventions for prenatal depression. Risk factor studies that met criteria feature demographic measures (lower socioeconomic status, less education, non-marital status, non-employment, less social support and health locus of control, unintended pregnancy, partner violence and history of child abuse) and physiological variables (cortisol, amylase, and pro-inflammatory cytokines and intrauterine artery resistance)...
February 2017: Journal of Pregnancy and Child Health
https://www.readbyqxmd.com/read/28693400/formulating-autism-systemically-part-2-a-12-year-prospective-case-study
#16
Nicky Brewerton, Katrina Robson, Patricia M Crittenden
This prospective case study illustrates the ideas on the developmental origins of some cases of autism that were described in Part 1 of this article. We explored and found support for several systemic hypotheses regarding the experience of 'Graeme' and his mother. Graeme's story is told prospectively from the age of 3 until 15. Three independent sources of information are reported: hypotheses from the literature and case review in Part 1 of this article, the school's experience, and observations from the assessments of attachment when Graeme was turning 6...
July 2017: Clinical Child Psychology and Psychiatry
https://www.readbyqxmd.com/read/28686535/prospective-evaluation-of-magnetic-resonance-imaging-and-18-f-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-at-diagnosis-and-before-maintenance-therapy-in-symptomatic-patients-with-multiple-myeloma-included-in-the-ifm-dfci-2009-trial-results
#17
Philippe Moreau, Michel Attal, Denis Caillot, Margaret Macro, Lionel Karlin, Laurent Garderet, Thierry Facon, Lotfi Benboubker, Martine Escoffre-Barbe, Anne-Marie Stoppa, Kamel Laribi, Cyrille Hulin, Aurore Perrot, Gerald Marit, Jean-Richard Eveillard, Florence Caillon, Caroline Bodet-Milin, Brigitte Pegourie, Veronique Dorvaux, Carine Chaleteix, Kenneth Anderson, Paul Richardson, Nikhil C Munshi, Herve Avet-Loiseau, Aurelie Gaultier, Jean-Michel Nguyen, Benoit Dupas, Eric Frampas, Françoise Kraeber-Bodere
Purpose Magnetic resonance imaging (MRI) and positron emission tomography-computed tomography (PET-CT) are important imaging techniques in multiple myeloma (MM). We conducted a prospective trial in patients with MM aimed at comparing MRI and PET-CT with respect to the detection of bone lesions at diagnosis and the prognostic value of the techniques. Patients and Methods One hundred thirty-four patients received a combination of lenalidomide, bortezomib, and dexamethasone (RVD) with or without autologous stem-cell transplantation, followed by lenalidomide maintenance...
July 7, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28680693/the-incorporation-of-emotion-regulation-skills-into-couple-and-family-based-treatments-for-post-traumatic-stress-disorder
#18
REVIEW
Deborah A Perlick, Frederic J Sautter, Julia J Becker-Cretu, Danielle Schultz, Savannah C Grier, Alexander V Libin, Manon Maitland Schladen, Shirley M Glynn
Post-traumatic stress disorder (PTSD) is a disabling, potentially chronic disorder that is characterized by re-experience and hyperarousal symptoms as well as the avoidance of trauma-related stimuli. The distress experienced by many veterans of the Vietnam War and their partners prompted a strong interest in developing conjoint interventions that could both alleviate the core symptoms of PTSD and strengthen family bonds. We review the evolution of and evidence base for conjoint PTSD treatments from the Vietnam era through the post-911 era...
2017: Military Medical Research
https://www.readbyqxmd.com/read/28665996/long-term-patterns-of-adherence-to-medication-therapy-among-patients-with-type-2-diabetes-mellitus-in-denmark-the-importance-of-initiation
#19
Majken Linnemann Jensen, Marit Eika Jørgensen, Ebba Holme Hansen, Lise Aagaard, Bendix Carstensen
AIMS: Poor adherence to medication therapy among type 2 diabetes patients is a clinical challenge. We aimed to determine which factors are associated with the three phases of long-term adherence to medication: initiation, implementation and discontinuation in a register-based study. METHODS: Adherence to six medicine groups (metformin, sulfonylureas, acetylsalicylic acid, thiazide diuretics, renin angiotensin system inhibitors, and statins) were analysed among 5,232 patients with type 2 diabetes at a tertiary referral hospital during 1998-2009...
2017: PloS One
https://www.readbyqxmd.com/read/28662338/effect-of-a-couples-relationship-enrichment-program-on-the-quality-of-marital-relationships-from-the-perspective-of-spouses-of-patients-with-multiple-sclerosis
#20
Ali Navidian, Nasrin Rezaee, Fatemeh Baniasadi, Mansour Shakiba
A relationship enrichment program involves family therapy with psychosocial training to improve relationship skills. This study was conducted to determine the effect of a couples' relationship enrichment program on marital relationship quality. This quasi-experimental study was conducted in 2016 with 80 spouses of patients, all members of the Multiple Sclerosis (MS) Center in Zahedan, Iran. The participants were randomly assigned to two groups: an intervention and a control group, each of which comprised 40 participants...
June 29, 2017: Issues in Mental Health Nursing
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