Tae-Yoon Kim, Joonoh Myoung, Youn Jung Lee, Jinyong Lee, Jongwook Kim, Seungeun Kim, Mi-Sun Kim, Bo Ram Beck, Seung Jin Hwang, Nae-Gyu Kang, Eui Taek Jeong
BACKGROUND: Transient receptor potential vanilloid 1 (TRPV1) is associated with skin sensitivity and mainly activated by capsaicin and heat. Interestingly, troxerutin can inhibit TRPV1 activation. However, its efficacy in reducing skin sensitivity remains undetermined. AIMS: We evaluated the efficacy of troxerutin in alleviating skin sensitivity using clinical tests and in vitro experiments. METHODS: For the in vitro experiment, HaCaT keratinocytes were pretreated with different concentrations of troxerutin, followed by incubation with 50 μM capsaicin for 1, 24, or 48 h...
May 8, 2024: Journal of Cosmetic Dermatology