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Yuyang Liu, Zhaoliang Li, Mao Pan
There are many heavy oil reservoirs in offshore oilfields in China. Steam and multiple thermal fluid stimulation technologies are of increasing interest and have been applied to an increasing number of projects. During the stimulation or displacement of heavy oil reservoirs during thermal recovery, several factors, such as reservoir heterogeneity, are prone to cause channeling phenomena and affect the thermal recovery effect of steam stimulation. According to the unique requirements for the stimulation of multiple thermal fluids for offshore heavy oil, this study used transmission, blocking and relieving, heat resistance and a comprehensive evaluation of parallel sand tube experiments to conduct a screening evaluation of plugging systems for the stimulation of multiple thermal fluids, screen out a commonly used plugging agent in the current stage and propose corresponding guidance for the selection basis...
2018: PloS One
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2018: PloS One
Xiaofei Li, Sarah Zito, Michelle Sinclair, Clive J C Phillips
China is the world's biggest livestock producer, and has a rapidly expanding intensive livestock production in response to growing demand. The large size of the country and geographical dispersion of the livestock production systems means that animals are often transported long distances to slaughter. This study investigated perceptions of animal welfare issues by stakeholders in the Chinese transport and slaughter industry using utility scores and adaptive conjoint analysis. An initial workshop for experts in this field identified key concerns; these were then included in a questionnaire, which was distributed electronically to stakeholders...
2018: PloS One
Jane L Ralphe, Robin B Dail
BACKGROUND: Approximately half of the 55,000 very low birth-weight infants (<1500 g) born in the United States each year develop bronchopulmonary dysplasia (BPD). Many etiologies have been associated with the development of BPD, including aberrant temperature/humidity levels of artificial ventilation. PURPOSE: The purpose of this literature review is to explore what is known regarding inspired air temperature/humidity levels from artificial ventilation in very premature infants, focusing on what levels these infants actually receive, and what factors impact these levels...
June 21, 2018: Advances in Neonatal Care: Official Journal of the National Association of Neonatal Nurses
Alessia Giannetto, Tiziana Cappello, Sabrina Oliva, Vincenzo Parrino, Giuseppe De Marco, Salvatore Fasulo, Angela Mauceri, Maria Maisano
Copper oxide nanoparticles (CuO NPs) are widely used in various industrial applications, i.e. semiconductor devices, batteries, solar energy converter, gas sensor, microelectronics, heat transfer fluids, and have been recently recognized as emerging pollutants of increasing concern for human and marine environmental health. Therefore, the toxicity of CuO NPs needs to be thoroughly understood. In this study, we evaluated the potential role of oxidative stress in CuO NP toxicity by exploring the molecular response of Arbacia lixula embryos to three CuO NP concentrations (0...
June 14, 2018: Aquatic Toxicology
Shuyan Wu, Pak-Lam Yu, Dave Wheeler, Steve Flint
OBJECTIVES: The aim of this study was to determine the gene expression associated with the persistence of a Listeria monocytogenes stationary phase population when facing lethal nisin treatment METHODS: RNA Seq analysis was used for gene expression profiling of the persister cells in rich medium (persister TN) compared with untreated cells (non-persister).The results were confirmed using RT PCR. RESULTS: Functional genes associated with the persister populations were identified in multiple systems, such as heat shock related stress response, cell wall synthesis, ATP-binding cassette (ABC) transport system, phosphotransferase system (PTS system), and SOS/DNA repair...
June 19, 2018: Journal of Global Antimicrobial Resistance
In-Sung Song, Yu Jeong Jeong, Seung Hun Jeong, Hyoung Kyu Kim, Nam-Chul Ha, MyungGeun Shin, Kyung Soo Ko, Byoung Doo Rhee, Sungbo Shim, Sung-Wuk Jang, Jin Han
Multiple myeloma (MM) is a neoplastic plasma cell disorder with high disease recurrence rates. Novel therapeutic approaches capable of improving outcomes in patients with MM are urgently required. The AKT signalling plays a critical regulatory role in MM pathophysiology, including survival, proliferation, metabolism, and has emerged as a key therapeutic target. Here, we identified a novel AKT inhibitor, HS1793, and defined its mechanism of action and clinical significance in MM. HS1793 disrupted the interaction between AKT and heat shock protein 90, resulting in protein phosphatase 2A-modulated phosphorylated-AKT (p-AKT) reduction...
June 19, 2018: Cancer Letters
D N Borg, I B Stewart, J T Costello, C C Drovandi, G M Minett
PURPOSE: This study examined the effect of environmental temperature deception on the rating of perceived exertion (RPE) during 30 min of fixed-intensity cycling in the heat. METHODS: Eleven trained male cyclists completed an incremental cycling test and four experimental trials. Trials consisted of 30 min cycling at 50% Pmax , once in 24 °C (CON) and three times in 33 °C. In the hot trials, participants were provided with accurate temperature feedback (HOT), or were deceived to believe the temperature was 28 °C (DECLOW ) or 38 °C (DECHIGH )...
June 19, 2018: Physiology & Behavior
Dong-Suk Kim, Poojya Anantharam, Andrea Hoffmann, Mitchell L Meade, Nadja Grobe, Jeffery M Gearhart, Elizabeth M Whitley, Belinda Mahama, Wilson K Rumbeiha
Acute exposure to high concentrations of H2 S causes severe brain injury and long-term neurological disorders, but the mechanisms involved are not known. To better understand the cellular and molecular mechanisms involved in acute H2 S-induced neurodegeneration we used a broad-spectrum proteomic analysis approach to identify key molecules and molecular pathways involved in the pathogenesis of acute H2 S-induced neurotoxicity and neurodegeneration. Mice were subjected to acute inhalation exposure of up to750 ppm of H2 S...
June 19, 2018: Toxicology and Applied Pharmacology
Terence L Kirley, Andrew B Norman
Monoclonal antibodies are very important in modern therapeutics and constitute a substantial percentage of newly approved drugs. Every therapeutic monoclonal antibody must be analyzed for structural and functional integrity, and all protein heterogeneities need to be identified and quantified. The conformational stabilities of the monoclonal antibodies are also important for antibody storage and handling stabilities. One of the first and simplest of the structural analysis techniques utilized is SDS-PAGE, which can be performed both with and without prior reduction to break disulfide bonds...
June 19, 2018: Biochemical and Biophysical Research Communications
Naomi J Petela, Thomas G Gligoris, Jean Metson, Byung-Gil Lee, Menelaos Voulgaris, Bin Hu, Sotaro Kikuchi, Christophe Chapard, Wentao Chen, Eeson Rajendra, Madhusudhan Srinivisan, Hongtao Yu, Jan Löwe, Kim A Nasmyth
Cohesin organizes DNA into chromatids, regulates enhancer-promoter interactions, and confers sister chromatid cohesion. Its association with chromosomes is regulated by hook-shaped HEAT repeat proteins that bind Scc1, namely Scc3, Pds5, and Scc2. Unlike Pds5, Scc2 is not a stable cohesin constituent but, as shown here, transiently replaces Pds5. Scc1 mutations that compromise its interaction with Scc2 adversely affect cohesin's ATPase activity and loading. Moreover, Scc2 mutations that alter how the ATPase responds to DNA abolish loading despite cohesin's initial association with loading sites...
June 21, 2018: Molecular Cell
O Azzolini, M T Barrera, J W Beeman, F Bellini, M Beretta, M Biassoni, C Brofferio, C Bucci, L Canonica, S Capelli, L Cardani, P Carniti, N Casali, L Cassina, M Clemenza, O Cremonesi, A Cruciani, A D'Addabbo, I Dafinei, S Di Domizio, F Ferroni, L Gironi, A Giuliani, P Gorla, C Gotti, G Keppel, L Marini, M Martinez, S Morganti, S Nagorny, M Nastasi, S Nisi, C Nones, D Orlandi, L Pagnanini, M Pallavicini, V Palmieri, L Pattavina, M Pavan, G Pessina, V Pettinacci, S Pirro, S Pozzi, E Previtali, A Puiu, F Reindl, C Rusconi, K Schäffner, C Tomei, M Vignati, A S Zolotarova
We report the result of the search for neutrinoless double beta decay of ^{82}Se obtained with CUPID-0, the first large array of scintillating Zn^{82}Se cryogenic calorimeters implementing particle identification. We observe no signal in a 1.83 kg yr ^{82}Se exposure, and we set the most stringent lower limit on the 0νββ ^{82}Se half-life T_{1/2}^{0ν}>2.4×10^{24}  yr (90% credible interval), which corresponds to an effective Majorana neutrino mass m_{ββ}<(376-770)  meV depending on the nuclear matrix element calculations...
June 8, 2018: Physical Review Letters
N Bhattacharjee, A A Sapozhnik, S Yu Bodnar, V Yu Grigorev, S Y Agustsson, J Cao, D Dominko, M Obergfell, O Gomonay, J Sinova, M Kläui, H-J Elmers, M Jourdan, J Demsar
We observe the excitation of collective modes in the terahertz (THz) range driven by the recently discovered Néel spin-orbit torques (NSOTs) in the metallic antiferromagnet Mn_{2}Au. Temperature-dependent THz spectroscopy reveals a strong absorption mode centered near 1 THz, which upon heating from 4 to 450 K softens and loses intensity. A comparison with the estimated eigenmode frequencies implies that the observed mode is an in-plane antiferromagnetic resonance (AFMR). The AFMR absorption strength exceeds those found in antiferromagnetic insulators, driven by the magnetic field of the THz radiation, by 3 orders of magnitude...
June 8, 2018: Physical Review Letters
Efstratios Mitridis, Thomas M Schutzius, Alba Sicher, Claudio U Hail, Hadi Eghlidi, Dimos Poulikakos
Inhibiting ice accumulation on surfaces is an energy-intensive task and is of significant importance in nature and technology where it has found applications in windshields, automobiles, aviation, renewable energy generation, and infrastructure. Existing methods rely on on-site electrical heat generation, chemicals, or mechanical removal, with drawbacks ranging from financial costs to disruptive technical interventions and environmental incompatibility. Here we focus on applications where surface transparency is desirable and propose metasurfaces with embedded plasmonically enhanced light absorption heating, using ultra-thin hybrid metal-dielectric coatings, as a passive, viable approach for de-icing and anti-icing, in which the sole heat source is renewable solar energy...
June 22, 2018: ACS Nano
Alberto Coccarelli, Hayder Hasan, Jason Carson, Dimitris Parthimos, Perumal Nithiarasu
Ageing plays a fundamental role in arterial blood transport and heat transfer within a human body. The aim of this work is to provide a comprehensive methodology, based on biomechanical considerations, for modelling arterial flow and energy exchange mechanisms in the body accounting for age-induced changes. The study outlines a framework for age-related modifications within several interlinked subsystems, which include: arterial stiffening, heart contractility variations, tissue volume and property changes, and thermoregulatory system deterioration...
June 22, 2018: International Journal for Numerical Methods in Biomedical Engineering
Zong-Liang Sun, Yu-Zhen Zhang, Feng Zhang, Jia-Wei Zhang, Guo-Can Zheng, Ling Tan, Chong-Zhi Wang, Lian-Di Zhou, Qi-Hui Zhang, Chun-Su Yuan
An efficient method combined with fingerprint and chemometric analyses was developed to evaluate the quality of the traditional Chinese medicine plant Penthorum chinense Pursh. Nine samples were collected from different regions during different harvest periods, and 17 components in the form of extracts were simultaneously examined to assess quality by using high-performance liquid chromatography. The hepatoprotective effects of components were investigated by assessing the inhibition of SMMC-7721 cell growth...
June 22, 2018: Food & Function
Lei Niu, Jianlin Xu, Wenlong Yang, Jiqiang Ma, Jinqiang Zhao, Chenghu Kang, Jiaqiang Su
Nano-Sb₂O₃ has excellent synergistic flame-retardant effects. It can effectively improve the comprehensive physical and mechanical properties of composites, reduce the use of flame retardants, save resources, and protect the environment. In this work, nanocomposites specimens were prepared by the melt-blending method. The thermal stability, mechanical properties, and flame retardancy of a nano-Sb₂O₃⁻brominated epoxy resin (BEO)⁻poly(butylene terephthalate) (PBT) composite were analyzed, using TGA and differential scanning calorimetry (DSC), coupled with EDX analysis, tensile testing, cone calorimeter tests, as well as scanning electron microscopy (SEM) and flammability tests (limiting oxygen index (LOI), UL94)...
June 22, 2018: Materials
Feng He, Bingxin Li, Gan Ai, Alex Machio Kange, Yancun Zhao, Xiong Zhang, Yifan Jia, Daolong Dou, Fengquan Liu, Haiqun Cao
Alternaria alternata (Fries) Keissler is a lethal pear pathogen that causes leaf black spot disease of pear in Southern China. Heat-stable activity factor (HSAF) is a polycyclic tetramate macrolactam (PTM) produced by Lysobacter enzymogenes and many other microbes with a broad-spectrum antifungal activity against many filamentous fungi. In this study, we evaluated the antifungal effect of HSAF against A. alternata and proposed its antifungal mechanism in A. alternata . We report that HSAF inhibited the mycelial growth of A...
June 22, 2018: International Journal of Molecular Sciences
Marylise Hebert-Schuster, Belinda Elisabeth Rotta, Brenna Kirkpatrick, Jean Guibourdenche, Marie Cohen
The glucose-regulated protein 78 (GRP78) is a molecular chaperone that is responsible for protein folding, which belongs to the heat shock protein 70 kDa (HSPA/HSP70). Because of the conjunction of GRP78 transcription with endoplasmic reticulum stress, the chaperone plays an important role in the unfolded protein response (UPR), which is induced after the accumulation of misfolded proteins. In the last years, a significant body of research concentrated on interplay between GRP78 and sexual steroid hormones...
June 22, 2018: International Journal of Molecular Sciences
Tso-Hsuan Chen, Yu-Chi Yeh, Ying-Chih Liao
In this study, a composite material with healable and foldable features is formulated for printed conductive patterns on rough surfaces, such as paper, cloth, and 3D-printed objects. Carbon nanotubes (CNT) are mixed with wax to formulate a solid composite for pen writing. The composite exhibits a low percolation threshold of 2.5 wt% CNT and an optimum resistance of 1000 m at 4.86 wt% CNT. The optimized CNT/wax composite can be written on various rough substrates, such as paper and clothes, to create conductive patterns for electronic conductors...
June 22, 2018: ACS Applied Materials & Interfaces
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