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https://www.readbyqxmd.com/read/28913915/home-use-remotely-supervised-and-remotely-controlled-transcranial-direct-current-stimulation-a-systematic-review-of-the-available-evidence
#1
REVIEW
Ulrich Palm, Ulrike Kumpf, Nora Behler, Linda Wulf, Beatrice Kirsch, Jana Wörsching, Daniel Keeser, Alkomiet Hasan, Frank Padberg
OBJECTIVES: Transcranial direct current stimulation (tDCS) is gaining growing importance in the treatment of neurological and psychiatric disorders and is currently investigated for home-based and remotely supervised applications. METHODS: Here, we systematically review the available evidence from a database search (PubMed, ICTRP, clinicaltrials.gov) from January 2000 to May 2017. RESULTS: We detected 22 original research papers, trial protocols or trial registrations dealing with tDCS as an add-on intervention to cognitive or physiotherapeutic intervention...
September 15, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/28913167/ictal-conduction-aphasia-and-ictal-angular-gyrus-syndrome-as-rare-manifestations-of-epilepsy-the-importance-of-ictal-testing-during-video-eeg-monitoring
#2
Johann Philipp Zöllner, Anja Haag, Anke Hermsen, Sebastian Bauer, Friederike Stahl, Karina Wulf, Katja Menzler, Philipp S Reif, Marlies Wagner, Axel Pagenstecher, Ulrich Sure, Susanne Knake, Felix Rosenow, Adam Strzelczyk
The aim of these two case reports is to demonstrate that a predefined, structured, multimodal clinical bed-side testing during seizures in a long-term video-EEG monitoring setting facilitates diagnosis of complex neuropsychological syndromes. To the best of our knowledge, we present the first case of conduction aphasia as the sole ictal semiology, and a patient with focal seizures producing an angular gyrus syndrome in the speech dominant hemisphere. The relevance of diagnosing ictal aphasic and angular gyrus syndromes and localizing the symptomatogenic zone is discussed...
2017: Epilepsy & Behavior Case Reports
https://www.readbyqxmd.com/read/28892152/pharmacokinetics-of-chlortetracycline-in-maternal-plasma-and-in-fetal-tissues-following-oral-administration-to-pregnant-ewes
#3
K Washburn, V R Fajt, P Plummer, E Papastavros, J F Coetzee, L W Wulf, S Washburn
The purpose of this study was to determine if concentrations of chlortetracycline could be detected in fetal plasma or tissues after administering an oral dose of chlortetracycline (CTC; 500 mg/head/day) reported to be effective in controlling Campylobacter spp. abortions. Five pregnant ewes were administered 250 mg/head twice a day (total dose 500 mg/hd/d) for 7 days. On the beginning of day 7, intravenous catheters were surgically implanted or inserted into the fetus and dam. Plasma samples were collected from the ewe and fetus at various time points before and up to 36 hr after the last dose of CTC...
September 11, 2017: Journal of Veterinary Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28890318/total-biosynthesis-of-the-pyrrolo-4-2-benzodiazepine-scaffold-tomaymycin-on-an-in%C3%A2-vitro-reconstituted-nrps-system
#4
Alexander von Tesmar, Michael Hoffmann, Jan Pippel, Antoine Abou Fayad, Stefan Dausend-Werner, Armin Bauer, Wulf Blankenfeldt, Rolf Müller
In vitro reconstitution and biochemical analysis of natural product biosynthetic pathways remains a challenging endeavor, especially if megaenzymes of the nonribosomal peptide synthetase (NRPS) type are involved. In theory, all biosynthetic steps may be deciphered using mass spectrometry (MS)-based analyses of both the carrier protein-coupled intermediates and the free intermediates. We here report the "total biosynthesis" of the pyrrolo[4,2]benzodiazepine scaffold tomaymycin using an in vitro reconstituted NRPS system...
August 24, 2017: Cell Chemical Biology
https://www.readbyqxmd.com/read/28883643/soil-organic-phosphorus-transformations-during-2000-years-of-paddy-rice-and-non-paddy-management-in-the-yangtze-river-delta-china
#5
Xiaoqian Jiang, Wulf Amelung, Barbara J Cade-Menun, Roland Bol, Sabine Willbold, Zhihong Cao, Erwin Klumpp
The contents and properties of soil organic phosphorus (Po) largely drive ecosystem productivity with increasing development of natural soil. We hypothesized that soil Po would initially increase with paddy management and then would persist under steady-state conditions. We analyzed soils from a 2000-year chronosequence of a rice-wheat rotation and an adjacent non-paddy 700-year chronosequence in Bay of Hangzhou (China) for their Po composition using solution (31)P-NMR after NaOH-EDTA extraction. Land reclamation promoted Po accumulation in both paddy and non-paddy topsoils (depths ≤ 18 cm) until steady-state equilibria were reached within 200 years of land use...
September 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28881992/image-based-spatiotemporal-causality-inference-for-protein-signaling-networks
#6
Xiongtao Ruan, Christoph Wülfing, Robert F Murphy
Motivation: Efforts to model how signaling and regulatory networks work in cells have largely either not considered spatial organization or have used compartmental models with minimal spatial resolution. Fluorescence microscopy provides the ability to monitor the spatiotemporal distribution of many molecules during signaling events, but as of yet no methods have been described for large scale image analysis to learn a complex protein regulatory network. Here we present and evaluate methods for identifying how changes in concentration in one cell region influence concentration of other proteins in other regions...
July 15, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28877513/predicting-functional-neuroanatomical-maps-from-fusing-brain-networks-with-genetic-information
#7
REVIEW
Florian Ganglberger, Joanna Kaczanowska, Josef M Penninger, Andreas Hess, Katja Bühler, Wulf Haubensak
Functional neuroanatomical maps provide a mesoscale reference framework for studies from molecular to systems neuroscience and psychiatry. The underlying structure-function relationships are typically derived from functional manipulations or imaging approaches. Although highly informative, these are experimentally costly. The increasing amount of publicly available brain and genetic data offers a rich source that could be mined to address this problem computationally. Here, we developed an algorithm that fuses gene expression and connectivity data with functional genetic meta data and exploits cumulative effects to derive neuroanatomical maps related to multi-genic functions...
September 3, 2017: NeuroImage
https://www.readbyqxmd.com/read/28874197/environmental-drivers-of-ixodes-ricinus-abundance-in-forest-fragments-of-rural-european-landscapes
#8
Steffen Ehrmann, Jaan Liira, Stefanie Gärtner, Karin Hansen, Jörg Brunet, Sara A O Cousins, Marc Deconchat, Guillaume Decocq, Pieter De Frenne, Pallieter De Smedt, Martin Diekmann, Emilie Gallet-Moron, Annette Kolb, Jonathan Lenoir, Jessica Lindgren, Tobias Naaf, Taavi Paal, Alicia Valdés, Kris Verheyen, Monika Wulf, Michael Scherer-Lorenzen
BACKGROUND: The castor bean tick (Ixodes ricinus) transmits infectious diseases such as Lyme borreliosis, which constitutes an important ecosystem disservice. Despite many local studies, a comprehensive understanding of the key drivers of tick abundance at the continental scale is still lacking. We analyze a large set of environmental factors as potential drivers of I. ricinus abundance. Our multi-scale study was carried out in deciduous forest fragments dispersed within two contrasting rural landscapes of eight regions, along a macroclimatic gradient stretching from southern France to central Sweden and Estonia...
September 6, 2017: BMC Ecology
https://www.readbyqxmd.com/read/28872490/menopausal-hormone-therapy-for-primary-prevention-why-the-uspstf-is-wrong
#9
Robert D Langer, James A Simon, Amos Pines, Rogerio A Lobo, Howard N Hodis, James H Pickar, David F Archer, Philip M Sarrel, Wulf H Utian
No abstract text is available yet for this article.
September 4, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28867433/epidemiology-of-back-pain-in-young-and-middle-aged-adults-a-longitudinal-population-cohort-survey-from-age-27-50-years
#10
Felix Angst, Jules Angst, Vladeta Ajdacic-Gross, André Aeschlimann, Wulf Rössler
BACKGROUND: Back pain is extremely common and a huge burden for both individuals and health care services. OBJECTIVE: The aim was to determine the prevalence and incidence of lumbar and cervical back pain over 23 years and to quantify associations with concomitant disorders. METHODS: Data on lumbar and cervical back pain, and mental disorders from the Zurich study, collected between 1986 (age men: 27/women: 28 years) and 2008 (age 49/50) were analyzed...
June 1, 2017: Psychosomatics
https://www.readbyqxmd.com/read/28865313/autonomy-facilitates-repeated-maximum-force-productions
#11
Takehiro Iwatsuki, Reza Abdollahipour, Rudolf Psotta, Rebecca Lewthwaite, Gabriele Wulf
Performer autonomy (or self-control) has consistently been shown to enhance motor learning, and it can also provide immediate benefits for motor performance. Autonomy is also a key variable in the OPTIMAL theory of motor learning (Wulf & Lewthwaite, 2016). It is assumed to contribute to enhanced expectancies and goal-action coupling, affecting performance effectiveness and efficiency. The purpose of the present study was to examine whether providing autonomy support by giving performers choices would enhance their ability to maintain maximum force levels...
August 30, 2017: Human Movement Science
https://www.readbyqxmd.com/read/28863373/plastics-in-soil-analytical-methods-and-possible-sources
#12
REVIEW
Melanie Bläsing, Wulf Amelung
At least 300 Mio t of plastic are produced annually, from which large parts end up in the environment, where it persists over decades, harms biota and enters the food chain. Yet, almost nothing is known about plastic pollution of soil; hence, the aims of this work are to review current knowledge on i) available methods for the quantification and identification of plastic in soil, ii) the quantity and possible input pathways of plastic into soil, (including first preliminary screening of plastic in compost), and iii) its fate in soil...
August 29, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28854061/lassoing-skill-through-learner-choice
#13
Gabriele Wulf, Takehiro Iwatsuki, Brittney Machin, Jessica Kellogg, Clint Copeland, Rebecca Lewthwaite
The authors examined several issues related to the motor learning benefits resulting from giving learners choices. In 2 experiments, participants practiced a novel task, throwing a lasso. In Experiment 1, giving learners a choice ostensibly irrelevant to performance (color of mat under target) resulted in enhanced learning relative to a control group. The choice group also reported more positive affect. Experiment 2 compared the effectiveness of task-irrelevant (mat color) versus task-relevant (video demonstrations of the skill) choices...
August 30, 2017: Journal of Motor Behavior
https://www.readbyqxmd.com/read/28838480/self-expanding-versus-balloon-expandable-stents-for-iliac%C3%A2-artery%C3%A2-occlusive-disease-the%C3%A2-randomized-ice-trial
#14
Hans Krankenberg, Thomas Zeller, Maja Ingwersen, Josefin Schmalstieg, Hans Martin Gissler, Sigrid Nikol, Iris Baumgartner, Nicolas Diehm, Estell Nickling, Stefan Müller-Hülsbeck, Rainer Schmiedel, Giovanni Torsello, Willibald Hochholzer, Christian Stelzner, Klaus Brechtel, Wulf Ito, Ralph Kickuth, Erwin Blessing, Marcus Thieme, Jaroslaw Nakonieczny, Thomas Nolte, Ragnar Gareis, Harald Boden, Sebastian Sixt
OBJECTIVES: Atherosclerosis of iliac arteries is widespread. As inflow vessels, they are of great clinical significance and increasingly being treated by endovascular means. Most commonly, stents are implanted. BACKGROUND: So far, due to a lack of comparative data, no guideline recommendations on the preferable stent type, balloon-expandable stent (BE) or self-expanding stent (SE), have been issued. METHODS: In this randomized, multicenter study, patients with moderate to severe claudication from common or external iliac artery occlusive disease were assigned 1:1 to either BE or SE...
August 28, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28834007/structures-of-the-n-terminal-domain-of-pqsa-in-complex-with-anthraniloyl-and-6-fluoroanthraniloyl-amp-substrate-activation-in-pseudomonas-quinolone-signal-pqs-biosynthesis
#15
Florian Witzgall, Wiebke Ewert, Wulf Blankenfeldt
Pseudomonas aeruginosa, a prevalent pathogen in nosocomial infections and a major burden in cystic fibrosis, uses three interconnected quorum-sensing systems to coordinate virulence processes. At variance with other Gram-negative bacteria, one of these systems relies on 2-alkyl-4(1H)-quinolones (Pseudomonas quinolone signal, PQS) and might hence be an attractive target for new anti-infective agents. Here we report crystal structures of the N-terminal domain of anthranilate-CoA ligase PqsA, the first enzyme of PQS biosynthesis, in complex with anthraniloyl-AMP and with 6-fluoroanthraniloyl-AMP (6FABA-AMP) at 1...
August 18, 2017: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/28830363/recovery-and-prediction-of-postoperative-muscle-power-is-it-still-a-problem
#16
Martin Zoremba, Dennis Kornmann, Benjamin Vojnar, Rene Burchard, Thomas Wiesmann, Hinnerk Wulf, Thomas Kratz
BACKGROUND: In the postoperative period, immediate recovery of muscular power is essential for patient safety, but this can be affected by anaesthetic drugs, opioids and neuromuscular blocking agents (NMBA). In this cohort study, we evaluated anaesthetic and patient-related factors contributing to reduced postoperative muscle power and pulse oximetric saturation. METHODS: We prospectively observed 615 patients scheduled for minor surgery. Premedication, general anaesthesia and respiratory settings were standardized according to standard operating procedures (SOP)...
August 22, 2017: BMC Anesthesiology
https://www.readbyqxmd.com/read/28827277/an-investigation-of-the-predictors-of-photoprotection-and-uvr-dose-to-the-face-in-patients-with-xp-a-protocol-using-observational-mixed-methods
#17
Jessica Walburn, Robert Sarkany, Sam Norton, Lesley Foster, Myfanwy Morgan, Kirby Sainsbury, Vera Araújo-Soares, Rebecca Anderson, Isabel Garrood, Jakob Heydenreich, Falko F Sniehotta, Rute Vieira, Hans Christian Wulf, John Weinman
INTRODUCTION: Xeroderma pigmentosum (XP) is a rare genetic condition caused by defective nucleotide excision repair and characterised by skin cancer, ocular and neurological involvement. Stringent ultraviolet protection is the only way to prevent skin cancer. Despite the risks, some patients' photoprotection is poor, with a potentially devastating impact on their prognosis. The aim of this research is to identify disease-specific and psychosocial predictors of photoprotection behaviour and ultraviolet radiation (UVR) dose to the face...
August 21, 2017: BMJ Open
https://www.readbyqxmd.com/read/28825703/virtual-reality-for-freely-moving-animals
#18
John R Stowers, Maximilian Hofbauer, Renaud Bastien, Johannes Griessner, Peter Higgins, Sarfarazhussain Farooqui, Ruth M Fischer, Karin Nowikovsky, Wulf Haubensak, Iain D Couzin, Kristin Tessmar-Raible, Andrew D Straw
Standard animal behavior paradigms incompletely mimic nature and thus limit our understanding of behavior and brain function. Virtual reality (VR) can help, but it poses challenges. Typical VR systems require movement restrictions but disrupt sensorimotor experience, causing neuronal and behavioral alterations. We report the development of FreemoVR, a VR system for freely moving animals. We validate immersive VR for mice, flies, and zebrafish. FreemoVR allows instant, disruption-free environmental reconfigurations and interactions between real organisms and computer-controlled agents...
August 21, 2017: Nature Methods
https://www.readbyqxmd.com/read/28815267/long-term-trend-in-sunscreen-use-among-beachgoers-in-denmark
#19
Ida M Heerfordt, Peter A Philipsen, Bettina Ø Larsen, Hans Christian Wulf
This observational study examined the trend from the 1990s to 2016 of sunscreen use, sun protection factor (SPF) and quantity of sunscreen applied amongst beachgoers in Denmark. In 1997, 1998, 1999 and 2016, a total of 1,306 beachgoers were asked if they had used sunscreen on a specific day and, if so, of what SPF. In 1992 and 2016 another 143 beachgoers had their sunscreen bottles weighed before and after application. The frequency of sunscreen use among women increased from 45% in 1997 to 78% in 2016, while frequency of use among men increased from 39% to 49%...
August 17, 2017: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/28813352/optimizing-motivation-and-attention-for-motor-performance-and-learning
#20
REVIEW
Rebecca Lewthwaite, Gabriele Wulf
We review three lines of recent research at an intersection of motor learning and sport psychology as they relate to motor skill acquisition: enhanced expectancies, autonomy support, and external attentional focus. Findings within these lines of research have been integrated into a new theory, the OPTIMAL (Optimizing Performance through Intrinsic Motivation and Attention for Learning) theory (i.e., OPTIMAL theory, Wulf and Lewthwaite, 2016), and have been applied in motor skill acquisition and performance. Implications range from more effective skill development in children and novice performers to athletes and performers in many fields, including clinical rehabilitation...
August 2017: Current Opinion in Psychology
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