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https://www.readbyqxmd.com/read/29135048/the-biomechanical-construction-of-the-horse-s-body-and-activity-patterns-of-three-important-muscles-of-the-trunk-in-the-walk-trot-and-canter
#1
K Kienapfel, H Preuschoft, A Wulf, H Wagner
The activity patterns of trunk muscles are commonly neglected, in spite of their importance for maintaining body shape. Analysis of the biomechanics of the trunk under static conditions has led to predictions of the activity patterns. These hypotheses are tested experimentally by surface electromyography (EMG). Five horses, with and without a rider, were examined in the walk, trot and canter. Footfall was synchronised with EMG by an accelerometer. Averages of ten consecutive cycles were calculated and compared by statistical methods...
November 14, 2017: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/29109428/serial-omics-of-p53-brca1-mouse-breast-tumor-and-normal-mammary-gland
#2
Susanne B Breitkopf, Mateus De Oliveira Taveira, Min Yuan, Gerburg M Wulf, John M Asara
This study demonstrates a liquid-liquid extraction for the sequential tandem mass spectrometry (LC-MS/MS) analysis of non-polar lipids, polar metabolites, proteins and phosphorylation sites from a single piece of tissue. Extraction of 10 mg BRCA-/-, p53-/- breast tumor tissue or normal mammary gland tissue with methyl-tert-butyl ether (MTBE) results in three phases: an upper non-polar phase containing 1,382 lipids, a lower polar phase with 805 metabolites and a precipitated protein pellet with 4,792 proteins with 1,072 phosphorylation sites...
November 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29097497/mds1-and-evi1-complex-locus-mecom-a-novel-candidate-gene-for-hereditary-hematological-malignancies
#3
Tim Ripperger, Winfried Hofmann, Jan C Koch, Katayoon Shirneshan, Detlef Haase, Gerald Wulf, Peter R Issing, Matthias Karnebogen, Gunnar Schmidt, Bernd Auber, Brigitte Schlegelberger, Thomas Illig, Birgit Zirn, Doris Steinemann
No abstract text is available yet for this article.
November 2, 2017: Haematologica
https://www.readbyqxmd.com/read/29090343/epidemiological-genetic-and-clinical-characterization-by-age-of-newly-diagnosed-acute-myeloid-leukemia-based-on-an-academic-population-based-registry-study-amlsg-bio
#4
Gabriele Nagel, D Weber, E Fromm, S Erhardt, M Lübbert, W Fiedler, T Kindler, J Krauter, P Brossart, A Kündgen, H R Salih, J Westermann, G Wulf, B Hertenstein, M Wattad, K Götze, D Kraemer, T Heinicke, M Girschikofsky, H G Derigs, H A Horst, C Rudolph, M Heuser, G Göhring, V Teleanu, L Bullinger, F Thol, V I Gaidzik, P Paschka, K Döhner, A Ganser, Hartmut Döhner, R F Schlenk
We describe genetic and clinical characteristics of acute myeloid leukemia (AML) patients according to age from an academic population-based registry. Adult patients with newly diagnosed AML at 63 centers in Germany and Austria were followed within the AMLSG BiO registry (NCT01252485). Between January 1, 2012, and December 31, 2014, data of 3525 patients with AML (45% women) were collected. The median age was 65 years (range 18-94). The comparison of age-specific AML incidence rates with epidemiological cancer registries revealed excellent coverage in patients < 70 years old and good coverage up to the age of 80...
October 31, 2017: Annals of Hematology
https://www.readbyqxmd.com/read/29084363/insights-into-the-dual-activity-of-a-bifunctional-dehydratase-cyclase-domain
#5
Kwang Hoon Sung, Gesche Berkhan, Tim Hollmann, Lisa Wagner, Wulf Blankenfeldt, Frank Hahn
Oxygen-containing heterocycles are a common structural motif of polyketide natural products and contribute significantly to their biological activity. However, there are only limited reports of the responsible cyclases. Here, we report structural and mechanistic investigations on AmbDH3, a polyketide synthase domain with dual activity as dehydratase (DH) and pyran-forming cyclase in ambruticin biosynthesis. AmbDH3 is similar to monofunctional DH domains, using H51 and D215 for dehydration. V173 was confirmed as a diagnostic residue for cyclisation activity by a mutational study and enzymatic in vitro experiments...
October 30, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/29079352/intense-phototoxic-reactions-to-photodynamic-therapy-in-immunosuppressed-renal-transplant-patients
#6
V K Ortner, M Haedersdal, H C Wulf, K Togsverd-Bo
No abstract text is available yet for this article.
October 24, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29070534/a-gut-feeling-about-developmental-programming-mechanisms-trimethylamine-n-oxide-may-enhance-atherosclerosis-in-offspring-of-hypercholesterolemic-mice
#7
EDITORIAL
Wulf Palinski
No abstract text is available yet for this article.
November 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/29070426/the-prevalence-of-mental-illness-in-homeless-people-in-germany
#8
Stefanie Schreiter, Felix Bermpohl, Michael Krausz, Stefan Leucht, Wulf Rössler, Meryam Schouler-Ocak, Stefan Gutwinski
BACKGROUND: The number of homeless people in Germany is increasing. Studies from multiple countries have shown that most homeless people suffer from mental illnesses that require treatment. Accurate figures on the prevalence of mental illness among the homeless in Germany can help improve care structures for this vulnerable group. METHODS: We carried out a systematic review and meta-analysis on the prevalence of mental illness among homeless people in Germany. RESULTS: 11 pertinent studies published from 1995 to 2013 were identified...
October 6, 2017: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/29065692/diffusion-ordered-nuclear-magnetic-resonance-spectroscopy-dosy-nmr-a-novel-tool-for-identification-of-phosphorus-compounds-in-soil-extracts
#9
Liming Wang, Wulf Amelung, Sabine Willbold
Liquid-state, one-dimension 31P nuclear magnetic resonance spectrometry (NMR) has greatly advanced our understanding of the composition of organic phosphorous in the environment. However, the correct assignment of signals is complicated by overlapping and shifting signals in different types of soils. We applied therefore for the first time diffusion-ordered nuclear magnetic spectroscopy (DOSY) to soil extracts, allowing us to separate phosphorus components in the second domain based on their translational diffusion coefficient...
October 25, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/29060942/family-and-home-in-cognitive-rehabilitation-after-brain-injury-the-importance-of-family-oriented-interventions
#10
Camilla Wulf-Andersen, Jesper Mogensen
Acquired brain injury (ABI) severely affects both the injured patient and her/his family. This fact alone calls for a therapeutic approach addressing not only the individual victim of ABI but also her/his family. Additionally, the optimal outcome of posttraumatic cognitive rehabilitation may be best obtained by supplementing the institution-based cognitive training with home-based training. Moving cognitive training and other therapeutic interventions into the home environment does, however, constitute an additional challenge to the family structure and psychological wellbeing of all family members...
2017: NeuroRehabilitation
https://www.readbyqxmd.com/read/29050061/-perioperative-anaphylaxia-on-drugs
#11
Wolfgang Pfützner, Hinnerk Wulf
The diagnostic evaluation of perioperative anaphylaxia is of great importance for the medical care of the affected persons in the context of renewed interventions in general anesthesia. The most frequent triggers include muscle relaxants, antibiotics, latex and analgesics of the type of the cyclooxygenase inhibitors, but other perioperatively administered drugs such as opioids, anesthetics, benzodiazepines, dyes, disinfectants and even corticosteroids or drug additives may also be the cause in rare cases. The most important aim is therefore the identification of the responsible drug, for which a near-time allergological diagnosis should be carried out within the first 4 weeks to 6 months after the reaction...
October 2017: Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie: AINS
https://www.readbyqxmd.com/read/29045498/novel-drug-targets-in-cell-wall-biosynthesis-exploited-by-gene-disruption-in-pseudomonas-aeruginosa
#12
Ayssar A Elamin, Susanne Steinicke, Wulf Oehlmann, Yvonne Braun, Hanaa Wanas, Eduard A Shuralev, Carmen Huck, Marko Maringer, Manfred Rohde, Mahavir Singh
For clinicians, Pseudomonas aeruginosa is a nightmare pathogen that is one of the top three causes of opportunistic human infections. Therapy of P. aeruginosa infections is complicated due to its natural high intrinsic resistance to antibiotics. Active efflux and decreased uptake of drugs due to cell wall/membrane permeability appear to be important issues in the acquired antibiotic tolerance mechanisms. Bacterial cell wall biosynthesis enzymes have been shown to be essential for pathogenicity of Gram-negative bacteria...
2017: PloS One
https://www.readbyqxmd.com/read/29038484/mechanical-on-chip-microwave-circulator
#13
S Barzanjeh, M Wulf, M Peruzzo, M Kalaee, P B Dieterle, O Painter, J M Fink
Nonreciprocal circuit elements form an integral part of modern measurement and communication systems. Mathematically they require breaking of time-reversal symmetry, typically achieved using magnetic materials and more recently using the quantum Hall effect, parametric permittivity modulation or Josephson nonlinearities. Here we demonstrate an on-chip magnetic-free circulator based on reservoir-engineered electromechanic interactions. Directional circulation is achieved with controlled phase-sensitive interference of six distinct electro-mechanical signal conversion paths...
October 16, 2017: Nature Communications
https://www.readbyqxmd.com/read/29037891/chemotherapy-based-stem-cell-mobilization-does-not-result-in-significant-paraprotein-reduction-in-myeloma-patients-in-the-era-of-novel-induction-regimens
#14
Anthony Oyekunle, Evgenii Shumilov, Philippe Kostrewa, Andreas Burchert, Lorenz Trümper, Patrick Wuchter, Gerald Wulf, Ulrike Bacher, Nicolaus Kröger
Novel induction agents markedly improved remission rates in multiple myeloma (MM), and the continued use of chemotherapy for CD34(+) stem cell mobilization (SCM) has been questioned. We examined the additional effect of chemotherapy in SCM regarding remission status/morbidity. We reviewed 236 consecutive MM patients (aged 36 to 75 years) with first autologous stem cell transplantation from January 2009 to March 2016 after chemotherapy-based SCM. Responses were measured by changes in intact Ig and free light chain levels before and after chemomobilization (International Myeloma Working Group [IMWG] criteria)...
October 13, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29036841/home-and-family-in-cognitive-rehabilitation-after-brain-injury-implementation-of-social-reserves
#15
Jesper Mogensen, Camilla Wulf-Andersen
The focus of the present article is the home and family environment of patients suffering acquired brain injury. In order to obtain the optimal outcome of posttraumatic cognitive rehabilitation it is important (a) to obtain a sufficient intensity of rehabilitative training, (b) to achieve the maximum degree of generalization from formalized training to the daily environment of the patient, and (c) to obtain the best possible utilization of "cognitive reserves" in the form of cognitive abilities and "strategies" acquired pretraumatically...
2017: NeuroRehabilitation
https://www.readbyqxmd.com/read/28983477/supportive-mental-health-self-monitoring-among-smartphone-users-with-psychological-distress-protocol-for-a-fully-mobile-randomized-controlled-trial
#16
Till Beiwinkel, Stefan Hey, Olaf Bock, Wulf Rössler
Mobile health (mHealth) could be widely used in the population to improve access to psychological treatment. In this paper, we describe the development of a mHealth intervention on the basis of supportive self-monitoring and describe the protocol for a randomized controlled trial to evaluate its effectiveness among smartphone users with psychological distress. Based on power analysis, a representative quota sample of N = 186 smartphone users will be recruited, with an over-sampling of persons with moderate to high distress...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/28980126/expression-of-prl-3-regulates-proliferation-and-invasion-of-breast-cancer-cells-in-vitro
#17
Isabel Radke, Martin Götte, Martin Smollich, Ninette Scharle, Ludwig Kiesel, Pia Wülfing
PURPOSE: The protein tyrosine phosphatase PRL-3 plays an important role in cancer cell migration, invasion and metastasis. In breast cancer, PRL-3 is overexpressed in 70-75% of tumors and even more frequently in lymph node metastases. Moreover, PRL-3 overexpression in breast cancer is associated with an adverse disease outcome. Aim of this study was to determine the role of PRL-3 in breast cancer cell proliferation, migration and invasion in vitro. METHODS: PRL-3 mRNA expression was evaluated in 6 breast cancer cell lines by quantitative real-time PCR...
October 4, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28968251/hypothermia-does-not-influence-liver-damage-and-function-in-a-porcine-polytrauma-model
#18
D Eschbach, K Horst, M Sassen, J Andruszkow, J Mohr, F Debus, N Vogt, T Steinfeldt, F Hildebrand, K Schöller, E Uhl, H Wulf, S Ruchholtz, H Pape, M Frink
BACKGROUND: Previous studies revealed evidence that induced hypothermia attenuates ischemic organ injuries after severe trauma. In the present study, the effect of hypothermia on liver damage was investigated in a porcine long term model of multi-system injury, consisting of blunt chest trauma, penetrating abdominal trauma, musculoskeletal injury, and hemorrhagic shockMETHODS: In 30 pigs, a standardized polytrauma including blunt chest trauma, penetrating abdominal trauma, musculoskeletal injury, and hemorrhagic shock of 45% of total blood volume was induced...
September 15, 2017: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
https://www.readbyqxmd.com/read/28947419/integrated-analysis-of-whole-genome-chip-seq-and-rna-seq-data-of-primary-head-and-neck-tumor-samples-associates-hpv-integration-sites-with-open-chromatin-marks
#19
Dylan Z Kelley, Emily Flam, Evgeny Izumchenko, Ludmila Danilova, Hildegard A Wulf, Theresa Guo, Dzov A Singman, Bahman Afsari, Alyza Skaist, Michael Considine, Elena Stavrovskaya, Justin A Bishop, William H Westra, Zubair Khan, Wayne M Koch, David Sidransky, Sarah J Wheelan, Joseph Califano, Alexander V Favorov, Elana J Fertig, Daria A Gaykalova
Chromatin alterations mediate mutations and gene expression changes in cancer. Chromatin immunoprecipitation followed by sequencing (ChIP-Seq) has been utilized to study genome-wide chromatin structure in human cancer cell lines, yet numerous technical challenges limit comparable analyses in primary tumors. Here we have developed a new whole-genome analytical pipeline to optimize ChIP-Seq protocols on patient-derived xenografts from human papillomavirus-related (HPV+) head and neck squamous cell carcinoma (HNSCC) samples...
September 25, 2017: Cancer Research
https://www.readbyqxmd.com/read/28936192/the-intricate-relationship-between-psychotic-like-experiences-and-associated-subclinical-symptoms-in-healthy-individuals
#20
Lui Unterrassner, Thomas A Wyss, Diana Wotruba, Helene Haker, Wulf Rössler
The interplay between subclinical psychotic, negative, and affective symptoms has gained increased attention regarding the etiology of psychosis spectrum and other mental disorders. Importantly, research has tended to not differentiate between different subtypes of psychotic-like experiences (PLE) although they may not have the same significance for mental health. In order to gain information on the subclinical interplay between specific PLE and other symptoms as well as the significance of PLE for mental health, we investigated their specific associations in 206 healthy individuals (20-60 years, 73 females) using correlational and linear regression analyses...
2017: Frontiers in Psychology
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