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Dragos Scarlet, Manuela Wulf, Juliane Kuhl, Martin Köhne, Natascha Ille, Alan J Conley, Christine Aurich
Anti-Müllerian hormone (AMH) has gained increasing interest as a biomarker for assessment of gonadal activity. The ability to predict the ovarian follicular reserve of prepubertal female horses (fillies) or to identify stallions with testicular pathologies already during their prepubertal life has not been analyzed so far. Both would help to select fertile horses and reduce costs associated with keeping animals. The objectives of the present study were to (1) assess AMH, LH, FSH, progesterone (females) and testosterone (males) dynamics in prepubertal horses from birth onwards and (2) determine whether AMH concentrations detected in plasma of prepubertal female and male horses are correlated with postpubertal gonadal development...
May 15, 2018: Theriogenology
Leif Erik Walther, Jana Wulfes, Alexander Blödow, Rüdiger Kniep
OBJECTIVES: To investigate morphology changes of artificial otoconia (CGC) in the presence of magnesium during growth under in vitro conditions. METHODS: Investigating human otoconia by environmental scanning electron microscope and determining their magnesium content by energy-dispersive X-ray microanalysis (EDX). Comparing structural and morphological data of human and artificial otoconia (CGC, Ca1 Mg0 ) without and with magnesium substitution (Ca1-x Mgx ). RESULTS: EDX- and X-ray data reveals that the inorganic component in human otoconia consists of calcite containing a minor amount of magnesium substitution (Ca1-x Mgx )...
May 15, 2018: Acta Oto-laryngologica
Essraa M Al-Essawe, Margareta Wallgren, Manuela Wulf, Christine Aurich, Beatriz Macías-García, Ylva Sjunnesson, Jane M Morrell
Seminal plasma (SP) contains proteins that may influence cryosurvival and prevent capacitation-like changes due to freezing and thawing. The objective of this study was to investigate the effect of adding pooled SP from "good" (GF) or "bad" (BF) freezer stallions on sperm cells' fertilizing ability. "Good freezers" refers to stallions that usually produce ejaculates which can withstand cryopreservation, whilst "bad freezer" stallions produce ejaculates which cannot tolerate the freezing process...
April 26, 2018: Theriogenology
Hinnerk Wulf
No abstract text is available yet for this article.
April 2018: Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie: AINS
Zhixin Zhou, Guo-Feng Luo, Verena Wulf, Itamar Willner
The study introduces an analytical platform for the detection of genes or aptamer-ligand complexes by nucleic acid barcode patterns generated by DNA machineries. The DNA machineries consist of nucleic acid scaffolds that include specific recognition sites for the different genes or aptamer-ligands analytes. The binding of the analytes to the scaffolds initiate, in the presence of the nucleotide mixture, cyclic polymerization/nicking machinery that yields displaced strands of variable lengths. The electrophoretic separation of the resulting strands provides barcode patterns for the specific detection of the different analytes...
May 8, 2018: Analytical Chemistry
Jeanette Kaae, Peter Alshede Philipsen, Hans Christian Wulf
INTRODUCTION: Necrobiosis lipoidica (NL) is a rare, treatment-resistant, granulomatous skin disease of unknown origin, frequently seen in patients with diabetes. METHODS: In this retrospective study we evaluated the long-term efficacy of methyl aminolaevulinate-based photodynamic therapy (MAL-PDT), including 80 treatments (70 conventional and 10 daylight PDT), on 65 unselected NL patients treated routinely in our clinic. Superficial curettage, avoiding skin oozing or bleeding, was performed prior to MAL application...
May 4, 2018: Photodiagnosis and Photodynamic Therapy
Peter Dreger, Mauricette Michallet, Paul Bosman, Sascha Dietrich, Mohamad Sobh, Ariane Boumendil, Arnon Nagler, Christof Scheid, Jan Cornelissen, Dietger Niederwieser, Lutz Müller, Elizabeth Vandenberghe, Ilaria Scortechini, Helene Schoemans, Niels S Andersen, Jürgen Finke, Domenico Russo, Per Ljungman, Jakob Passweg, Michel van Gelder, Nadira Durakovic, Helene Labussiere-Wallet, Tobias Berg, Gerald Wulf, Wolfgang Bethge, Donald Bunjes, Stefan Stilgenbauer, Maria Elisa Canepari, Michel Schaap, Christopher P Fox, Nicolaus Kröger, Silvia Montoto, Johannes Schetelig
The aim of this retrospective study was to investigate the safety and efficacy of allogeneic hematopoietic cell transplantation (alloHCT) in patients pre-treated with ibrutinib. Eligible were patients aged >18 years allotransplanted for chronic lymphocytic leukemia (CLL) or mantle cell lymphoma (MCL) after prior exposure to ibrutinib who were registered with the EBMT registry. Seventy patients (CLL 48, MCL 22) were included. At the time of alloHCT, 73% of the patients were ibrutinib responsive. All patients except one engrafted, and acute GVHD grade 2-4 (3-4) was observed in 49% (12%) of 68 evaluable patients...
May 4, 2018: Bone Marrow Transplantation
Florian Witzgall, Tobias Depke, Michael Hoffmann, Martin Empting, Mark Brönstrup, Rolf Müller, Wulf Blankenfeldt
Pseudomonas aeruginosa is a bacterial pathogen that causes life-threatening infections in immunocompromised patients. It produces a large armory of saturated and mono-unsaturated 2-alkyl-4(1H)-quinolones (AQs) or AQ N-oxides (AQNOs) that serve as signaling molecules to control the production of virulence factors, are involved in membrane vesicle formation and iron chelation and also have e.g. antibiotic properties. It has been shown that the FabH-like heterodimeric enzyme PqsBC catalyzes the last step in the biosynthesis of the most abundant AQ congener 2-heptyl-4(1H)-quinolone (HHQ) by condensing octanoyl-coenzyme A (CoA) with 2-aminobenzoylacetate (2-ABA), but the basis for the large number of other AQs/AQNOs produced by P...
May 3, 2018: Chembiochem: a European Journal of Chemical Biology
Peter Paschka, Richard F Schlenk, Daniela Weber, Axel Benner, Lars Bullinger, Michael Heuser, Verena I Gaidzik, Felicitas Thol, Mridul Agrawal, Veronica Teleanu, Michael Lübbert, Walter Fiedler, Markus Radsak, Jürgen Krauter, Heinz-A Horst, Richard Greil, Karin Mayer, Andrea Kündgen, Uwe Martens, Gerhard Heil, Helmut R Salih, Bernd Hertenstein, Carsten Schwänen, Gerald Wulf, Elisabeth Lange, Michael Pfreundschuh, Mark Ringhoffer, Michael Girschikofsky, Thomas Heinicke, Doris Kraemer, Gudrun Göhring, Arnold Ganser, Konstanze Döhner, Hartmut Döhner
In this phase Ib/IIa study ( Identifier: NCT00850382) of the German-Austrian AML Study Group (AMLSG) the multikinase inhibitor dasatinib was added to intensive induction and consolidation chemotherapy and administered as single agent for 1-year maintenance in first-line treatment of adult patients with core-binding factor (CBF) acute myeloid leukemia (AML). The primary combined end point in this study was safety and feasibility, and included the rates of early (ED) and hypoplastic (HD) deaths, pleural/pericardial effusion 3°/4° and liver toxicity 3°/4°, and the rate of refractory disease...
April 17, 2018: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
Joern Krausze, Thomas W Hercher, Dagmar Zwerschke, Martin L Kirk, Wulf Blankenfeldt, Ralf R Mendel, Tobias Kruse
The molybdenum cofactor (Moco) is a redox-active prosthetic group found in the active site of Moco- dependent enzymes, which are vitally important for life. Moco biosynthesis involves several enzymes that catalyze the subsequent conversion of GTP to cyclic pyranopterin monophoshpate (cPMP), molybdopterin (MPT), adenylated MPT (MPT-AMP) and finally Moco. While the underlying principles of cPMP, MPT, and MPT-AMP formation are well-understood, the molybdenum insertase (Mo-insertase) catalyzed final Moco maturation step is not...
May 1, 2018: Biochemical Journal
Bjoern Chapuy, Chip Stewart, Andrew J Dunford, Jaegil Kim, Atanas Kamburov, Robert A Redd, Mike S Lawrence, Margaretha G M Roemer, Amy J Li, Marita Ziepert, Annette M Staiger, Jeremiah A Wala, Matthew D Ducar, Ignaty Leshchiner, Ester Rheinbay, Amaro Taylor-Weiner, Caroline A Coughlin, Julian M Hess, Chandra S Pedamallu, Dimitri Livitz, Daniel Rosebrock, Mara Rosenberg, Adam A Tracy, Heike Horn, Paul van Hummelen, Andrew L Feldman, Brian K Link, Anne J Novak, James R Cerhan, Thomas M Habermann, Reiner Siebert, Andreas Rosenwald, Aaron R Thorner, Matthew L Meyerson, Todd R Golub, Rameen Beroukhim, Gerald G Wulf, German Ott, Scott J Rodig, Stefano Monti, Donna S Neuberg, Markus Loeffler, Michael Pfreundschuh, Lorenz Trümper, Gad Getz, Margaret A Shipp
Diffuse large B cell lymphoma (DLBCL), the most common lymphoid malignancy in adults, is a clinically and genetically heterogeneous disease that is further classified into transcriptionally defined activated B cell (ABC) and germinal center B cell (GCB) subtypes. We carried out a comprehensive genetic analysis of 304 primary DLBCLs and identified low-frequency alterations, captured recurrent mutations, somatic copy number alterations, and structural variants, and defined coordinate signatures in patients with available outcome data...
April 30, 2018: Nature Medicine
Arlo Radtke, Finja Hennig, Raphael Ikogho, Johannes Hammel, Petra Anheuser, Christian Wülfing, Gazanfer Belge, Klaus-Peter Dieckmann
BACKGROUND: Accumulating evidence suggests serum levels of microRNA (miR)-371a-3p to be a novel tumour marker of testicular germ cell tumours (GCTs). Presently, there is only limited information regarding the velocity of decline of serum levels in response to treatment. PATIENTS AND METHODS: Twenty-four patients with testicular GCT (20 seminoma, 4 nonseminoma, median age 40 years) with clinical stage 1 had measurements of serum levels of miR-371a-3p preoperatively and repeatedly on the following 3 days...
April 26, 2018: Urologia Internationalis
J Narbutt, P A Philipsen, A Lesiak, T Sandberg Liljendahl, D Segerbäck, J Heydenreich, D Chlebna-Sokol, P Olsen, G I Harrison, A Pearson, K Baczynska, M Rogowski-Tylman, H C Wulf, A R Young
BACKGROUND: Childhood solar ultraviolet radiation (UVR) exposure increases the risk of skin cancer in adulthood, which is associated with mutations caused by UVR-induced cyclobutane pyrimidine dimers (CPD). Solar UVR is also the main source of vitamin D, essential for healthy bone development in children. OBJECTIVES: The impact of a 12-day Baltic Sea (54o N) beach holiday on serum 25-dihydroxyvitamin D (25(OH)D3 ) and CPD was assessed in 32 healthy Polish children (skin types I-IV)...
April 24, 2018: British Journal of Dermatology
Hans C Wulf
BACKGROUND: Conventional photodynamic therapy (PDT) is associated with side effects, primarily related to the waiting time between pre-treatment with application of photosensitizer and illumination. Pain during illumination is a major issue for the patients and options for effective pain relief are limited. Post-treatment inflammation can often be severe and cause inconvenient down-time for the patients and their employers. METHODS: To avoid the problems of pain and patients crowding in the clinic we eliminated red light treatment of high PpIX concentration and introduced illumination in daylight which may be performed at home...
April 19, 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
Michael P Hengartner, Jules Angst, Wulf Rössler
No abstract text is available yet for this article.
April 20, 2018: Psychotherapy and Psychosomatics
Johanna Schaefer, Niels Tegtbauer, Wulf Pfeiffer, Thomas O F Wagner, Holger Storf
se-atlas - the health service information platform for rare diseases - is part of the German National Action Plan for People with Rare Diseases. The website provides an overview of health care providers and support groups focusing on rare diseases in Germany. Since the start of se-atlas in 2013, several strategies are being developed and evaluated. This paper gives an overview about the expectations and visions for se-atlas at the beginning of the project, the challenges and lessons learned within the project period and how se-atlas is implemented today...
2018: Studies in Health Technology and Informatics
Laëtitia Misson, Reto Burn, Allegra Vit, Julia Hildesheim, Mariia A Beliaeva, Wulf Blankenfeldt, Florian P Seebeck
Ergothioneine is an emerging factor in cellular redox homeostasis in bacteria, fungi, plants, and animals. Reports that ergothioneine biosynthesis may be important for the pathogenicity of bacteria and fungi raise the question as to how this pathway is regulated and whether the corresponding enzymes may be therapeutic targets. The first step in ergothioneine biosynthesis is catalyzed by the methyltransferase EgtD that converts histidine into N-α-trimethylhistidine. This report examines the kinetic, thermodynamic and structural basis for substrate, product, and inhibitor binding by EgtD from Mycobacterium smegmatis...
April 16, 2018: ACS Chemical Biology
Oleg Siidra, Diana Nekrasova, Wulf Depmeier, Nikita Chukanov, Anatoly Zaitsev, Rick Turner
White lead or basic lead carbonate, 2PbCO3 ·Pb(OH)2 , the synthetic analogue of hydrocerussite Pb3 (OH)2 (CO3 )2 , has been known since antiquity as the most frequently used white paint. A number of different minerals and synthetic materials compositionally and structurally related to hydrocerussite have been described within the last two decades. Herein, a review is given of general structural principles, chemical variations and IR spectra of the rapidly growing family of hydrocerussite-related minerals and synthetic materials...
April 1, 2018: Acta Crystallographica Section B, Structural Science, Crystal Engineering and Materials
Kevin A Becker, Jeffrey T Fairbrother, Kaylee F Couvillion
Attentional focus research suggests an external focus leads to improved motor performance compared to an internal focus (Wulf in Int Rev Sport Exerc Psychol 6:77-104, 2013), but skilled athletes often report using an internal focus (Fairbrother et al., Front Psychol 7:1028, 2016) and sometimes shifting between different foci in the preparation and execution phases of performance (Bernier et al. in J Appl Sport Psychol 23:326-341, 2011; Bernier et al. in Sport Psychol 30:256-266, 2016). To date, focus shifts have been unexplored in experimental research, thus the purpose of this study was to determine the effect of shifting focus between the preparation and execution phases of a standing long jump...
April 3, 2018: Psychological Research
Oleg I Siidra, Evgeny V Nazarchuk, Dmitry O Charkin, Nikita V Chukanov, Wulf Depmeier, Sergey N Bocharov, Mikhail I Sharikov
The synthesis, structure, and infrared spectroscopy properties of the new organically templated uranyl sulfate Na(phgH⁺)₇[(UO₂)₆(SO₄)10 ](H₂O)3.5 ( 1 ), obtained at room temperature by evaporation from aqueous solution, are reported. Its structure contains unique uranyl sulfate [(UO₂)₆(SO₄)10 ]8- nanotubules templated by protonated N -phenylglycine (C₆H₅NH₂CH₂COOH)⁺. Their internal diameter is 1.4 nm. Each of the nanotubules is built from uranyl sulfate rings sharing common SO₄ tetrahedra...
April 3, 2018: Nanomaterials
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