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Fabienne Harrisberger, Roman Buechler, Renata Smieskova, Claudia Lenz, Anna Walter, Laura Egloff, Kerstin Bendfeldt, Andor E Simon, Diana Wotruba, Anastasia Theodoridou, Wulf Rössler, Anita Riecher-Rössler, Undine E Lang, Karsten Heekeren, Stefan Borgwardt
Reduction in hippocampal volume is a hallmark of schizophrenia and already present in the clinical high-risk state. Nevertheless, other subcortical structures, such as the thalamus, amygdala and pallidum can differentiate schizophrenia patients from controls. We studied the role of hippocampal and subcortical structures in clinical high-risk individuals from two cohorts. High-resolution T1-weighted structural MRI brain scans of a total of 91 clinical high-risk individuals and 64 healthy controls were collected in two centers...
2016: NPJ Schizophrenia
Wei Yang, Wulf Paschen
Folding and processing newly synthesized proteins are vital functions of the endoplasmic reticulum that are sensitive to a variety of stress conditions. The unfolded protein response is activated to restore endoplasmic reticulum function impaired by stress. While we know that brain ischemia impairs endoplasmic reticulum function, the role of unfolded protein response activation in post-ischemic recovery of neurologic function is only beginning to emerge. Here, we summarize what is known about endoplasmic reticulum stress and unfolded protein response in brain ischemia and discuss recent findings from myocardial ischemia studies that could help to advance research on endoplasmic reticulum stress and unfolded protein response in brain ischemia...
October 12, 2016: Journal of Cerebral Blood Flow and Metabolism
Sibylle Metzler, Diane Dvorsky, Christine Wyss, Carlos Nordt, Susanne Walitza, Karsten Heekeren, Wulf Rössler, Anastasia Theodoridou
An important aim in schizophrenia research is to optimize the prediction of psychosis and to improve strategies for early intervention. The objectives of this study were to explore neurocognitive performance in individuals at risk for psychosis and to optimize predictions through a combination of neurocognitive and psychopathological variables. Information on clinical outcomes after 24 months was available from 118 subjects who had completed an extensive assessment at baseline. Subjects who had converted to psychosis were compared with subjects who had not...
September 30, 2016: Psychiatry Research
Nils-Torge Telle, Jörn Moock, Sandra Heuchert, Vivian Schulte, Wulf Rössler, Wolfram Kawohl
Sickness absence from work due to experienced distress and mental health issues has continuously increased over the past years in Germany. To investigate how this alarming development can be counteracted, we conducted a randomized controlled trial evaluating a job coaching intervention to maintain the working capacity of members of staff and ultimately prevent sickness absence. Our sample included N = 99 employees who reported mental distress due to work-related problems. The intervention group (n = 58) received between 8 and 12 individual job coaching sessions in which they worked with a professional job coach to reduce their mental distress...
2016: Frontiers in Public Health
C V Nissen, I M Heerfordt, S R Wiegell, C S Mikkelsen, H C Wulf
BACKGROUND: Photodynamic therapy (PDT) with methyl aminolevulinate (MAL) is highly effective for treating actinic keratosis (AKs) on the face/scalp, but less effective on the extremities. Insufficient accumulation of protoporphyrin IX (PpIX) may cause these inferior efficacy rates. However, it is possible to increase PpIX accumulation by extending MAL application time and/or pretreating the skin with curettage. OBJECTIVES: To investigate whether increased PpIX accumulation improves the effect of MAL-PDT for AKs in a randomized intraindividual study...
October 1, 2016: British Journal of Dermatology
Richard F Schlenk, Michael Lübbert, Axel Benner, Alexander Lamparter, Jürgen Krauter, Wolfgang Herr, Hans Martin, Helmut R Salih, Andrea Kündgen, Heinz-A Horst, Peter Brossart, Katharina Götze, David Nachbaur, Mohammed Wattad, Claus-Henning Köhne, Walter Fiedler, Martin Bentz, Gerald Wulf, Gerhard Held, Bernd Hertenstein, Hans Salwender, Verena I Gaidzik, Brigitte Schlegelberger, Daniela Weber, Konstanze Döhner, Arnold Ganser, Hartmut Döhner
The aim of this clinical trial was to evaluate the impact of all-trans retinoic acid (ATRA) in combination with chemotherapy and to assess the NPM1 status as biomarker for ATRA therapy in younger adult patients (18-60 years) with acute myeloid leukemia (AML). Patients were randomized for intensive chemotherapy with or without open-label ATRA (45 mg/m(2), days 6-8; 15 mg/m(2), days 9-21). Two cycles of induction therapy were followed by risk-adapted consolidation with high-dose cytarabine or allogeneic hematopoietic cell transplantation...
October 3, 2016: Annals of Hematology
Dennis Knierim, Wulf Menzel, Stephan Winter
The complete genome sequence of an isolate of euphorbia ringspot virus (EuRSV) was determined by deep sequencing and rapid amplification of cDNA ends (RACE) RT-PCR. It has an RNA genome of 10,154 nucleotides in size, excluding the poly(A) tail, and encodes a polyprotein of 3265 amino acids. Phylogenetic analysis from this study supports the earlier taxonomic assignment to the genus Potyvirus; however, a gene encoding the HAM1h protein, inserted between NIb and CP of the EuRSV genome, which was previously only observed for cassava brown streak virus and Ugandan cassava brown streak virus of the genus Ipomovirus, is an unusual feature of this potyvirus, which otherwise has typical potyvirus genome features...
September 29, 2016: Archives of Virology
Ida M Heerfordt, Christoffer V Nissen, Thomas Poulsen, Peter A Philipsen, Hans Christian Wulf
The severity of dysplasia and expression of p53 in actinic keratosis (AK) is of importance for the transformation to squamous cell carcinoma. It is assumed that it is most important to treat thick AKs as they are believed to be more dysplastic than thin AKs. However, a relation between AK thickness and dysplasia or the expression of p53 has never been demonstrated. The aim of this study was to investigate this possible relation. Sixty-six AKs were included for clinical and histological examination. Prior to performing a punch biopsy, the clinical thickness of each AK was measured objectively using two scale bars with a thickness of 0...
September 27, 2016: Scientific Reports
Lisa K B Holper, Alekandra Aleksandrowicz, Mario Müller, Vladeta Ajdacic-Gross, Helene Haker, Andreas J Fallgatter, Florence Hagenmuller, Wolfram Kawohl, Wulf Rössler
A psychosis phenotype can be observed below the threshold of clinical detection. The study aimed to investigate whether subclinical psychotic symptoms are associated with deficits in controlling emotional interference, and whether cortical brain and cardiac correlates of these deficits can be detected using functional near-infrared spectroscopy (fNIRS). A data set derived from a community sample was obtained from the Zurich Program for Sustainable Development of Mental Health Services. 174 subjects (mean age 29...
2016: Frontiers in Behavioral Neuroscience
Patricia Kipnis, Benjamin J Turk, David A Wulf, Juan Carlos LaGuardia, Vincent XLiu, Matthew M Churpek, Santiago Romero-Brufau, Gabriel J Escobar
: Patients in general medical-surgical wards who experience unplanned transfer to the intensive care unit (ICU) show evidence of physiologic derangement 6 to 24 hours prior to their deterioration. With increasing availability of electronic medical records (EMRs), automated early warning scores (EWSs) are becoming feasible. OBJECTIVE: To describe the development and performance of an automated EWS based on EMR data. MATERIALS AND METHODS: We used a discrete-time logistic regression model to obtain an hourly risk score to predict unplanned transfer to the ICU within the next 12 hours...
September 19, 2016: Journal of Biomedical Informatics
Andrés Már Erlendsson, Daniel Thaysen-Petersen, Christiane Bay, Andreas Hald, Kresten Skak, John Robert Zibert, Uwe Paasch, Hans Christian Wulf, Merete Haedersdal
BACKGROUND AND AIM: Ingenol mebutate (IngMeb) is an effective treatment for actinic keratosis. In this study, we hypothesized that repeated treatments with IngMeb may prevent progression of UV-induced photodamage, and that concurrent application of a corticosteroid may reduce IngMeb-induced local skin responses (LSR). METHODS: Hairless mice (n = 60; 3 groups of 20 mice) were irradiated with solar simulated ultraviolet radiation (UVR) throughout the study. Five single treatments with IngMeb were given at 4-week intervals (Days 21, 49, 77, 105, and 133)...
2016: PloS One
Marco Witkowski, Hans-Christian Mochmann, Ursula Rauch, Wulf Knie, Ulf Landmesser, Carsten Skurk
No abstract text is available yet for this article.
October 2016: Critical Care Medicine
Konstantinos Karatolios, Caroline Rolfes, Hinnerk Wulf, Bernhard Schieffer
Cardiovascular complications, particularly perioperative myocardial infarction (PMI), are major contributors to mortaliyt after noncardiac surgery. PMI often occurs unnoticed without symptoms or ECG changes. Despite ist silent presentation, PMI is associated with increased mortality. The combination of high associated mortality and diagnostic challenges mandates increased awareness of PMI. Perioperative myocardial infarction may result from plaque rupture (PMI type I) or be caused by a myocardial supply-demand imbalance of oxygen without plaque rupture (PMI type II)...
September 2016: Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie: AINS
Edelmann J, Dobosz T, Sobieszczanska M, Kawecka-Negrusz M, Dreßler J, Nastainczyk-Wulf M
Congenital long QT-syndrome (LQTS) is an inherited cardiac arrhythmia, which is characterized by a prolonged QT interval which predisposes to sudden cardiac death due to ventricular arrhythmias. The altered functions are based on different mutations in LQTS-associated genes. In this study, we performed a mutation analysis for the detection of 125 LQTS-associated single nucleotide polymorphisms (SNPs) focused on the genes KCNQ1, KCNH2, and SCN5A by using the SNaPshot multiplex minisequencing technique. Furthermore, we investigated 152 autopsy-negative cases from younger adults and infants, as well as samples from patients with clinically suspicion for LQTS, in which we found two types of variations...
September 9, 2016: International Journal of Legal Medicine
I M Heerfordt, H C Wulf
BACKGROUND: Erythropoietic protoporphyria (EPP) is a rare genetic disease that causes severe sensitivity to visible light as a result of protoporphyrin IX (PpIX) accumulation in the skin. OBJECTIVES: To establish a noninvasive method to measure PpIX in the skin of patients with EPP and to investigate how skin PpIX relates to erythrocyte PpIX and photosensitivity. METHODS: Skin PpIX was measured in 25 patients with EPP by calculating the difference in PpIX fluorescence before and after complete photobleaching of PpIX using controlled illumination...
September 7, 2016: British Journal of Dermatology
Diana Paksarian, Lihong Cui, Jules Angst, Vladeta Ajdacic-Gross, Wulf Rössler, Kathleen R Merikangas
Importance: Epidemiologic evidence indicates that most of the general population will experience a mental health disorder at some point in their lives. However, few prospective population-based studies have estimated trajectories of risk for mental disorders from young through middle adulthood to estimate the proportion of individuals who experience persistent mental disorder across this age period. Objectives: To describe the proportion of the population who experience persistent mental disorder across adulthood and to estimate latent trajectories of disorder risk across this age period...
October 1, 2016: JAMA Psychiatry
Martin Pichler, Verena Stiegelbauer, Petra Vychytilova-Faltejskova, Cristina Ivan, Hui Ling, Elke Winter, Xinna Zhang, Matthew Goblirsch, Annika Wulf-Goldenberg, Masahisa Ohtsuka, Johannes Haybaeck, Marek Svoboda, Armin Gerger, Yoshinaga Okugawa, Gerald Hoefler, Ajay Ajay, Ondrej Slaby, George A Calin
PURPOSE: Characterization of colorectal cancer (CRC) transcriptome by high-throughput techniques has enabled the discovery of several differentially expressed involving previously unreported microRNAs abnormalities. Here, we followed a systematic approach on a global scale to identify microRNAs as clinical outcome predictors, and further validated them in the clinical and experimental setting. EXPERIMENTAL DESIGN: Genome-wide microRNA sequencing data of 228 CRC patients from the cancer genome atlas (TCGA) dataset were analyzed as a screening cohort to identify microRNAs significantly associated with survival according to stringent pre-specified criteria...
September 6, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
Michael P Hengartner, Silvia Passalacqua, Gisela Heim, Andreas Andreae, Wulf Rössler, Agnes von Wyl
PURPOSE: The aim of this post hoc analysis was to examine self-reported recovery following a post-discharge intervention and to focus on the moderators of this intervention programme. METHODS: RCT using parallel group block randomisation, including 151 patients with ≤3 hospitalisations within the last 3 years, a GAF score ≤60, and aged 18-64 years, assessed at two psychiatric hospitals from Zurich, Switzerland, between September 2011 and February 2014. In the present study, the main outcome was the OQ-45 as assessed prior to discharge from the index hospitalisation and at 12-month follow-up...
September 6, 2016: Social Psychiatry and Psychiatric Epidemiology
Yi-Chuan Chen, Hsiao-Ying Kuo, Ulrich Bornschein, Hiroshi Takahashi, Shih-Yun Chen, Kuan-Ming Lu, Hao-Yu Yang, Gui-May Chen, Jing-Ruei Lin, Yi-Hsin Lee, Yun-Chia Chou, Sin-Jhong Cheng, Cheng-Ting Chien, Wolfgang Enard, Wulf Hevers, Svante Pääbo, Ann M Graybiel, Fu-Chin Liu
Cortico-basal ganglia circuits are critical for speech and language and are implicated in autism spectrum disorder, in which language function can be severely affected. We demonstrate that in the mouse striatum, the gene Foxp2 negatively interacts with the synapse suppressor gene Mef2c. We present causal evidence that Mef2c inhibition by Foxp2 in neonatal mouse striatum controls synaptogenesis of corticostriatal inputs and vocalization in neonates. Mef2c suppresses corticostriatal synapse formation and striatal spinogenesis, but can itself be repressed by Foxp2 through direct DNA binding...
September 5, 2016: Nature Neuroscience
Claudia Engelhardt, Frank Petereit, Matthias Lechtenberg, Ursula Liefländer-Wulf, Andreas Hensel
The upper aerial parts and leaf tips of Myrothamnus flabellifolia Welw. (Myrothamnaceae), a resurrection plant indigenous to southern Africa, are used in African traditional medicine for infections of the respiratory and urinary system as well as for inflammation of mucosa and skin. Within a phytochemical investigation of the herbal material from M. flabellifolia the flavonoid fraction was shown to contain quercetin 10 as well as the respective 3-O-β-d-galactosides, glucosides, -glucuronides and 3-O-α-l-rhamnosides of quercetin (6, 7, 8, 26) and kaempferol (1, 2, 3, 9)...
October 2016: Fitoterapia
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