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https://www.readbyqxmd.com/read/28098598/science-of-intracrinology-in-postmenopausal-women
#1
Fernand Labrie, Alain Bélanger, Georges Pelletier, Céline Martel, David F Archer, Wulf H Utian
OBJECTIVE: To illustrate the marked differences between classical endocrinology that distributes hormones to all tissues of the body through the bloodstream and the science of intracrinology, whereby each cell of each peripheral tissue makes a small and appropriate amount of estrogens and androgens from the inactive precursor dehydroepiandrosterone (DHEA), DHEA being mainly of adrenal origin. Because only the inactivated sex steroids are released in the blood, influence in the other tissues is avoided...
January 16, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28098197/dantrolene-versus-amiodarone-for-cardiopulmonary-resuscitation-a-randomized-double-blinded-experimental-study
#2
Thomas Wiesmann, Dennik Freitag, Wolfgang Dersch, Daphne Eschbach, Marc Irqsusi, Thorsten Steinfeldt, Hinnerk Wulf, Carsten Feldmann
Dantrolene was introduced for treatment of malignant hyperthermia. It also has antiarrhythmic properties and may thus be an alternative to amiodarone for the treatment of ventricular fibrillation (VF). Aim of this study was to compare the return of spontaneous circulation (ROSC) with dantrolene and amiodarone in a pig model of cardiac arrest. VF was induced in anesthetized pigs. After 8 min of untreated VF, chest compressions and ventilation were started and one of the drugs (amiodarone 5 mg kg(-1), dantrolene 2...
January 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28096533/impact-of-pretreatment-characteristics-and-salvage-strategy-on-outcome-in-patients-with-relapsed-acute-myeloid-leukemia
#3
R F Schlenk, P Frech, D Weber, P Brossart, H-A Horst, D Kraemer, G Held, M Ringhoffer, A Burchardt, G Kobbe, K Götze, D Nachbaur, T Fischer, M Lübbert, H R Salih, H Salwender, G Wulf, E Koller, M Wattad, W Fiedler, S Kremers, H Kirchen, B Hertenstein, P Paschka, V I Gaidzik, V Teleanu, M Heuser, F Thol, K Döhner, J Krauter, A Ganser, H Döhner
Leukemia accepted article preview online, 18 January 2017. doi:10.1038/leu.2017.22.
January 18, 2017: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/28094222/recent-developments-in-the-isolation-biological-function-biosynthesis-and-synthesis-of-phenazine-natural-products
#4
REVIEW
Nikolaus Guttenberger, Wulf Blankenfeldt, Rolf Breinbauer
Phenazines are natural products which are produced by bacteria or by archaeal Methanosarcina species. The tricyclic ring system enables redox processes, which producing organisms use for oxidation of NADH or for the generation of reactive oxygen species (ROS), giving them advantages over other microorganisms. In this review we summarize the progress in the field since 2005 regarding the isolation of new phenazine natural products, new insights in their biological function, and particularly the now almost completely understood biosynthesis...
January 5, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28093604/pretreatment-with-5-fluorouracil-cream-enhances-the-efficacy-of-daylight-mediated-photodynamic-therapy-for-actinic-keratosis
#5
Christoffer V Nissen, Ida Marie Heerfordt, Stine R Wiegell, Carsten S Mikkelsen, Hans C Wulf
The efficacy of photodynamic therapy (PDT) with methyl aminolevulinate is reduced when treating actinic keratosis (AK) on the extremities in comparison with the face and scalp. Studies indicate that PDT efficacy can be improved by combining PDT with other treatment modalities. This randomized intra-individual study investigated whether pretreatment with topical 5% 5-fluorouracil (5-FU) enhanced the treatment efficacy of daylight-mediated PDT in 24 patients with AKs on the hands. One hand of each patient was given 7 days of pretreatment with 5-FU twice daily before daylight-PDT, whereas the other hand was treated with daylight-PDT alone...
January 17, 2017: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/28089598/impact-of-focused-intraoperative-transthoracic-echocardiography-by-anesthesiologists-on-management-in-hemodynamically-unstable-high-risk-noncardiac-surgery-patients
#6
Thomas Kratz, Thorsten Steinfeldt, Maik Exner, Marco Campo Dell Orto, Nina Timmesfeld, Caroline Kratz, Martin Skrodzki, Hinnerk Wulf, Martin Zoremba
OBJECTIVES: Focused transthoracic echocardiography (TTE) is used perioperatively for surgical patients. Intraoperative application of TTE is feasible, but its benefits remain unclear. The intention of this study was to investigate the effect of intraoperative TTE on the management of high-risk noncardiac surgery patients. DESIGN: A prospective interventional study. SETTING: Single-center university hospital. PARTICIPANTS: Fifty consecutive hemodynamically unstable high-risk patients anesthetized for noncardiac surgery...
November 2, 2016: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/28087004/gimme-a-complex-resident-mononuclear-phagocytes-in-the-kidney-as-monitors-of-circulating-antigens-and-immune-complexes
#7
Wulf Tonnus, Christian Hugo, Andreas Linkermann
Over the past decade, researchers have made substantial progress in characterizing a network of mononuclear phagocytes in the kidney, which variously have been referred to as resident macrophages or dendritic cells. Two recent studies, published in Cell and Kidney International, have identified these resident macrophages/dendritic cells as local immune monitors of peritubular capillaries for circulating antigens and immune complexes. These cells appear to represent an early line of defense against circulating infectious particles and immune complexes, but the resulting inflammatory response may also contribute to interstitial inflammation and kidney disease progression...
February 2017: Kidney International
https://www.readbyqxmd.com/read/28078206/infectious-atopic-and-inflammatory-diseases-childhood-adversities-and-familial-aggregation-are-independently-associated-with-the-risk-for-mental-disorders-results-from-a-large-swiss-epidemiological-study
#8
Vladeta Ajdacic-Gross, Aleksandra Aleksandrowicz, Stephanie Rodgers, Margot Mutsch, Anja Tesic, Mario Müller, Wolfram Kawohl, Wulf Rössler, Erich Seifritz, Enrique Castelao, Marie-Pierre F Strippoli, Caroline Vandeleur, Roland von Känel, Rosa Paolicelli, Markus A Landolt, Cornelia Witthauer, Roselind Lieb, Martin Preisig
AIM: To examine the associations between mental disorders and infectious, atopic, inflammatory diseases while adjusting for other risk factors. METHODS: We used data from PsyCoLaus, a large Swiss Population Cohort Study (n = 3720; age range 35-66). Lifetime diagnoses of mental disorders were grouped into the following categories: Neurodevelopmental, anxiety (early and late onset), mood and substance disorders. They were regressed on infectious, atopic and other inflammatory diseases adjusting for sex, educational level, familial aggregation, childhood adversities and traumatic experiences in childhood...
December 22, 2016: World Journal of Psychiatry
https://www.readbyqxmd.com/read/28076875/muss-metformin-wegen-der-gefahr-der-laktatazidose-48%C3%A2-h-vor-op-abgesetzt-werden
#9
Hinnerk Wulf, Leopold Eberhart
No abstract text is available yet for this article.
January 2017: Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie: AINS
https://www.readbyqxmd.com/read/28071193/screening-of-esbl-producing-enterobacteriacae-concomitant-with-low-degree-of-transmission-in-intensive-care-and-bone-marrow-transplant-units
#10
Giuseppe Valenza, Monika Schulze, Petra Friedrich, Wulf Schneider-Brachert, Thomas Holzmann, Silke Nickel, Verena Lehner-Reindl, Christiane Höller
BACKGROUND: Extended-spectrum β-lactamase-producing Enterobacteriaceae (ESBL-E) are spreading worldwide in both hospital and community settings. In this study, the molecular epidemiology and the transmission modalities of ESBL-E in intensive care- and bone marrow transplant were investigated. METHODS: All patients included in this study were screened for presence of ESBL-E on admission and weekly. Relevant β-lactamase genes were identified by PCR and sequencing...
January 10, 2017: Infectious Diseases
https://www.readbyqxmd.com/read/28070632/-prevention-of-perioperative-hypothermia-implementation-of-the-s3-guideline
#11
E-P Horn, E Klar, J Höcker, A Bräuer, B Bein, H Wulf, A Torossian
To improve perioperative quality and patient safety, the German S3 guideline should be consistently implemented to avoid perioperative hypothermia. Perioperative normothermia is a quality indicator and should be achieved by anesthesiologists and surgeons. To detect hypothermia early during the perioperative process, measuring body temperature should be started 1-2 h preoperatively. Patients should be actively warmed for 20-30 min before starting anesthesia. Prewarming is most effective and should be included in the preoperative process...
January 9, 2017: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
https://www.readbyqxmd.com/read/28068614/the-gender-difference-in-depressive-prevalence-is-due-to-high-prevalence-of-somatic-depression-among-women-who-do-not-have-depressed-relatives
#12
Brett Silverstein, Vladeta Ajdacic-Gross, Wulf Rossler, Jules Angst
BACKGROUND: Given that several studies have found the gender difference in depression to be rooted in psychosocial forces and others have shown the difference to be due to a gender difference in somatic depression, we compared the gender difference in somatic depression among respondents who reported no relative depressed with that of all other depressed respondents. METHODS: Respondents in a representative sample from the Zurich study who met criteria for somatic depression and reported no relatives (first-degree, or parents, or mothers, or fathers in separate analyses) with depression were compared to other depressed respondents as to gender...
January 4, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28060808/steroid-biomarkers-revisited-improved-source-identification-of-faecal-remains-in-archaeological-soil-material
#13
Katharina Prost, Jago Jonathan Birk, Eva Lehndorff, Renate Gerlach, Wulf Amelung
Steroids are used as faecal markers in environmental and in archaeological studies, because they provide insights into ancient agricultural practices and the former presence of animals. Up to now, steroid analyses could only identify and distinguish between herbivore, pig, and human faecal matter and their residues in soils and sediments. We hypothesized that a finer differentiation between faeces of different livestock animals could be achieved when the analyses of several steroids is combined (Δ5-sterols, 5α-stanols, 5β-stanols, epi-5β-stanols, stanones, and bile acids)...
2017: PloS One
https://www.readbyqxmd.com/read/28057735/increased-age-associated-mortality-risk-in-hla-mismatched-hematopoietic-stem-cell-transplantation
#14
Daniel Fürst, Dietger Niederwieser, Donald Bunjes, Eva M Wagner, Martin Gramatzki, Gerald Wulf, Carlheinz R Müller, Christine Neuchel, Chrysanthi Tsamadou, Hubert Schrezenmeier, Joannis Mytilineos
We investigated a possible interaction between age-associated risk and HLA-mismatch associated risk on prognosis in different age categories of recipients of unrelated hematopoietic stem cell transplants (HSCT) (n=3019). Patients over 55 years of age transplanted with 8/10 donors showed a mortality risk of 2.27 (CI 1.70-3.03, p<0.001) and 3.48 (CI 2.49-4.86, p<0.001) when compared to 10/10 matched patients in the same age group and to 10/10 matched patients aged 18-35 years, respectively. Compared to 10/10 matched transplantations within each age category, the HR for 8/10 matched transplantation was 1...
January 5, 2017: Haematologica
https://www.readbyqxmd.com/read/28056637/triple-play-additive-contributions-of-enhanced-expectancies-autonomy-support-and-external-attentional-focus-to-motor-learning
#15
Gabriele Wulf, Rebecca Lewthwaite, Priscila Cardozo, Suzete Chiviacowsky
In the OPTIMAL theory of motor learning (Wulf & Lewthwaite, 2016), 3 factors are postulated to facilitate learning: Enhanced expectancies (EE) for performance, autonomy support (AS), and an external focus (EF) of attention. Enhancing learners' expectancies for future performance (e. g., through positive feedback) benefits learning. Further, supporting learners' need for autonomy (e.g., by giving them choices) has been found to promote learning. Finally, directing learners' attention to the intended movement effect (external focus) has beneficial effects for learning...
January 5, 2017: Quarterly Journal of Experimental Psychology: QJEP
https://www.readbyqxmd.com/read/28012989/rhamnolipids-form-drug-loaded-nanoparticles-for-dermal-drug-delivery
#16
Felix Müller, Stefan Hönzke, Wulf-Ole Luthardt, Ee Lin Wong, Michael Unbehauen, Jörg Bauer, Rainer Haag, Sarah Hedtrich, Eckart Rühl, Jörg Rademann
Bacterial biosurfactants are nature's strategy to solubilize and ingest hydrophobic molecules and nutrients using a fully biodegradable transport system. Eight structurally defined rhamnolipids were selected and investigated as potential drug carrier systems. Depending on the molecular structures defining their packing parameters, the rhamnolipids were found to form spherical nanoparticles with precisely defined average sizes between 5 and 100 nm, low polydispersity, and stability over a broad concentration range as revealed from dynamic light scattering and electron microscopy...
December 21, 2016: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/27993796/phase-i-dose-escalation-study-of-the-pi3kinase-pathway-inhibitor-bkm120-and-the-oral-poly-adp-ribose-polymerase-parp-inhibitor-olaparib-for-the-treatment-of-high-grade-serous-ovarian-and-breast-cancer
#17
U A Matulonis, G M Wulf, W T Barry, M Birrer, S N Westin, S Farooq, K M Bell-McGuinn, E Obermayer, C Whalen, T Spagnoletti, W Luo, H Liu, R C Hok, C Aghajanian, D B Solit, G B Mills, B S Taylor, H Won, M F Berger, S Palakurthi, J Liu, L C Cantley, E Winer
BACKGROUND: Based upon preclinical synergy in murine models, we performed a phase 1 trial to determine the maximum tolerated dose (MTD), toxicities, pharmacokinetics, and biomarkers of response for the combination of BKM120, a PI3K inhibitor, and olaparib, a PARP inhibitor. PATIENTS AND METHODS: Olaparib was administered twice daily (tablet formulation) and BKM120 daily on a 28-day cycle, both orally. A 3 + 3 dose-escalation design was employed with the primary objective of defining the combination MTD, and secondary objectives were to define toxicities, activity, and pharmacokinetic profiles...
December 19, 2016: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/27940564/the-aibr-isovaleryl-coenzyme-a-regulator-and-its-dna-binding-site-a-model-for-the-regulation-of-alternative-de-novo-isovaleryl-coenzyme-a-biosynthesis-in-myxococcus-xanthus
#18
Tobias Bock, Carsten Volz, Vanessa Hering, Andrea Scrima, Rolf Müller, Wulf Blankenfeldt
Isovaleryl coenzyme A (IV-CoA) is an important building block of iso-fatty acids. In myxobacteria, IV-CoA is essential for the formation of signaling molecules involved in fruiting body formation. Leucine degradation is the common source of IV-CoA, but a second, de novo biosynthetic route to IV-CoA termed AIB (alternative IV-CoA biosynthesis) was recently discovered in M. xanthus The AIB-operon contains the TetR-like transcriptional regulator AibR, which we characterize in this study. We demonstrate that IV-CoA binds AibR with micromolar affinity and show by gelshift experiments that AibR interacts with the promoter region of the AIB-operon once IV-CoA is present...
December 9, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27934054/gold-nanorods-as-plasmonic-sensors-for-particle-diffusion
#19
Verena Wulf, Fabian Knoch, Thomas Speck, Carsten Sönnichsen
Plasmonic gold nanoparticles are normally used as sensor to detect analytes permanently bound to their surface. If the interaction between the analyte and the nanosensor surface is negligible, it only diffuses through the sensor's sensing volume, causing a small temporal shift of the plasmon resonance position. By using a very sensitive and fast detection scheme, we are able to detect these small fluctuations in the plasmon resonance. With the help of a theoretical model consistent with our detection geometry, we determine the analyte's diffusion coefficient...
December 1, 2016: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/27925577/the-role-of-ultrasound-compared-to-biopsy-of-temporal-arteries-in-the-diagnosis-and-treatment-of-giant-cell-arteritis-tabul-a-diagnostic-accuracy-and-cost-effectiveness-study
#20
Raashid Luqmani, Ellen Lee, Surjeet Singh, Mike Gillett, Wolfgang A Schmidt, Mike Bradburn, Bhaskar Dasgupta, Andreas P Diamantopoulos, Wulf Forrester-Barker, William Hamilton, Shauna Masters, Brendan McDonald, Eugene McNally, Colin Pease, Jennifer Piper, John Salmon, Allan Wailoo, Konrad Wolfe, Andrew Hutchings
BACKGROUND: Giant cell arteritis (GCA) is a relatively common form of primary systemic vasculitis, which, if left untreated, can lead to permanent sight loss. We compared ultrasound as an alternative diagnostic test with temporal artery biopsy, which may be negative in 9-61% of true cases. OBJECTIVE: To compare the clinical effectiveness and cost-effectiveness of ultrasound with biopsy in diagnosing patients with suspected GCA. DESIGN: Prospective multicentre cohort study...
November 2016: Health Technology Assessment: HTA
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