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https://www.readbyqxmd.com/read/29342026/reflections-on-a-life-in-menopause
#1
Wulf H Utian
No abstract text is available yet for this article.
February 2018: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/29331602/a-cross-continental-analysis-of-weight-gain-psychiatric-diagnoses-and-medication-use-during-inpatient-psychiatric-treatment-the-international-study-on-physical-illness-in-mentally-ill
#2
Christina Engelke, Christian Lange-Asschenfeldt, Stephanie Peter, Kai G Kahl, Karel Frasch, Jens I Larsen, Graziella G Bickel, Bernhard Bork, Bent A Jacobsen, Signe O Wallenstein-Jensen, Christoph Lauber, Birthe Mogensen, Jørgen A Nielsen, Wulf Rössler, Kenji J Tsuchiya, Kristian L Toftegaard, Ulla A Andersen, Richard Uwakwe, Povl Munk-Jørgensen, Joachim Cordes
Weight gain among psychiatric inpatients is a widespread phenomenon. This change in body mass index (BMI) can be caused by several factors. Based on recent research, we assume the following factors are related to weight gain during psychiatric inpatient treatment: psychiatric medication, psychiatric diagnosis, sex, age, weight on admission and geographic region of treatment. 876 of originally recruited 2328 patients met the criteria for our analysis. Patients were recruited and examined in mental health care centres in Nigeria (N = 265), Japan (N = 145) and Western-Europe (Denmark, Germany and Switzerland; N = 466)...
December 22, 2017: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/29328978/sun-behaviour-on-the-beach-monitored-by-webcam-photos
#3
I M Heerfordt, P A Philipsen, H C Wulf
OBJECTIVES: To prevent skin cancer, the general population is recommended to limit time in the sun, to wear clothes and to seek shade around noon. This study aimed to investigate the number of beachgoers, the duration of sun exposure, and clothing worn during the day on a beach in Copenhagen. STUDY DESIGN: Observational, descriptive study. METHODS: On 11 beach days in 2014 and 2015, beachgoers were counted every hour from 8:00 to 20:00. It was noted if they wore clothes or swimwear...
January 9, 2018: Public Health
https://www.readbyqxmd.com/read/29310722/habitat-properties-are-key-drivers-of-borrelia-burgdorferi-s-l-prevalence-in-ixodes-ricinus-populations-of-deciduous-forest-fragments
#4
Steffen Ehrmann, Sanne C Ruyts, Michael Scherer-Lorenzen, Jürgen Bauhus, Jörg Brunet, Sara A O Cousins, Marc Deconchat, Guillaume Decocq, Pieter De Frenne, Pallieter De Smedt, Martin Diekmann, Emilie Gallet-Moron, Stefanie Gärtner, Karin Hansen, Annette Kolb, Jonathan Lenoir, Jessica Lindgren, Tobias Naaf, Taavi Paal, Marcus Panning, Maren Prinz, Alicia Valdés, Kris Verheyen, Monika Wulf, Jaan Liira
BACKGROUND: The tick Ixodes ricinus has considerable impact on the health of humans and other terrestrial animals because it transmits several tick-borne pathogens (TBPs) such as B. burgdorferi (sensu lato), which causes Lyme borreliosis (LB). Small forest patches of agricultural landscapes provide many ecosystem services and also the disservice of LB risk. Biotic interactions and environmental filtering shape tick host communities distinctively between specific regions of Europe, which makes evaluating the dilution effect hypothesis and its influence across various scales challenging...
January 8, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29258202/impact-of-uvr-exposure-pattern-on-squamous-cell-carcinoma-a-dose-delivery-and-dose-response-study-in-pigmented-hairless-mice
#5
Catharina M Lerche, Katrine Togsverd-Bo, Peter A Philipsen, Hans Christian Wulf
Cumulative lifetime ultraviolet radiation (UVR) is an important factor in the development of squamous cell carcinoma. This study examines the impact of UVR exposure pattern on tumor development. Hairless C3.Cg/TifBomTac immunocompetent pigmented mice (n = 351) were irradiated with 12 standard erythema doses (SED)/week, given as 2 SED ×6, 3 SED ×4, 4 SED ×3, or 6 SED ×2 (dose-delivery study) or 0, 0.6, 1.2, 2, 3 or 4 SED ×3/week (dose-response study). All mice were irradiated until development of 3 tumors of 4 mm each...
December 16, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29251683/menopause-25th-anniversary-past-success-and-future-direction
#6
Isaac Schiff, Wulf H Utian, JoAnn V Pinkerton
No abstract text is available yet for this article.
January 2018: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/29249226/tranexamic-acid-prophylaxis-in-hip-and-knee-joint-replacement
#7
Matthias Goldstein, Carsten Feldmann, Hinnerk Wulf, Thomas Wiesmann
BACKGROUND: The antifibrinolytic agent tranexamic acid (TXA) is widely used for the prevention and treatment of hyperfibrinolytic states, such as in severe polytrauma. It can also be used for the systemic prevention of hemorrhage in elective orthopedic procedures. In this review, we assess the efficacy and risks of the prophylactic administration of tranexamic acid before major endoprosthetic surgery of the hip and knee. METHODS: This review is based on pertinent articles retrieved by a selective literature search in the PubMed and Cochrane Library databases...
December 1, 2017: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/29244160/interplay-between-the-catabolite-repression-control-protein-crc-hfq-and-rna-in-hfq-dependent-translational-regulation-in-pseudomonas-aeruginosa
#8
Elisabeth Sonnleitner, Alexander Wulf, Sébastien Campagne, Xue-Yuan Pei, Michael T Wolfinger, Giada Forlani, Konstantin Prindl, Laetitia Abdou, Armin Resch, Frederic H-T Allain, Ben F Luisi, Henning Urlaub, Udo Bläsi
In Pseudomonas aeruginosa the RNA chaperone Hfq and the catabolite repression control protein (Crc) act as post-transcriptional regulators during carbon catabolite repression (CCR). In this regard Crc is required for full-fledged Hfq-mediated translational repression of catabolic genes. RNAseq based transcriptome analyses revealed a significant overlap between the Crc and Hfq regulons, which in conjunction with genetic data supported a concerted action of both proteins. Biochemical and biophysical approaches further suggest that Crc and Hfq form an assembly in the presence of RNAs containing A-rich motifs, and that Crc interacts with both, Hfq and RNA...
December 13, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29240076/from-public-health-genomics-to-precision-public-health-a-20-year-journey
#9
REVIEW
Muin J Khoury, M Scott Bowen, Mindy Clyne, W David Dotson, Marta L Gwinn, Ridgely Fisk Green, Katherine Kolor, Juan L Rodriguez, Anja Wulf, Wei Yu
In this paper, we review the evolution of the field of public health genomics in the United States in the past two decades. Public health genomics focuses on effective and responsible translation of genomic science into population health benefits. We discuss the relationship of the field to the core public health functions and essential services, review its evidentiary foundation, and provide examples of current US public health priorities and applications. We cite examples of publications to illustrate how Genetics in Medicine reflected the evolution of the field...
December 14, 2017: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/29238308/duration-of-absence-from-work-is-related-to-psychopathology-personality-and-sociodemographic-variables-in-a-longitudinal-cohort
#10
Alex Gamma, Roman Schleifer, Ingeborg Warnke, Vladeta Ajdacic-Gross, Wulf Rössler, Jules Angst, Michael Liebrenz
Objective: To examine, in a non-clinical sample, the association of psychopathology, personality, sociodemographic information, and psychosocial indicators of non-occupational functioning with the duration of absence from work in the past 12 months. Method: A longitudinal community cohort of 591 adults from Switzerland was analyzed using multilevel ordered logistic regression, with several alternative models as robustness checks. Psychopathology was assessed using the total score (Global Severity Index) of the Symptom Check List-90 Revised...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29235160/photoprotection-by-sunscreen-depends-on-time-spent-on-application
#11
Ida M Heerfordt, Linnea R Torsnes, Peter A Philipsen, Hans Christian Wulf
BACKGROUND: To be effective, sunscreens must be applied in a sufficient quantity and reapplication is recommended. No previous study has investigated whether time spent on sunscreen application is important for the achieved photoprotection. AIM: To determine whether time spent on sunscreen application is related to the amount of sunscreen used during a first and second application. METHODS: Thirty-one volunteers wearing swimwear applied sunscreen twice in a laboratory environment...
December 13, 2017: Photodermatology, Photoimmunology & Photomedicine
https://www.readbyqxmd.com/read/29232438/refractory-or-relapsed-aggressive-b-cell-lymphoma-failing-r-chop-an-analysis-of-patients-treated-on-the-ricover-60-trial
#12
B Glass, A J Dohm, L H Truemper, M Pfreundschuh, A Bleckmann, G G Wulf, A Rosenwald, M Ziepert, N Schmitz
Background: The prognosis of elderly patients with aggressive B-non-Hodgkin's lymphoma after first lymphoma-related treatment failure (TF-L) is not well described. Methods: We analysed patient characteristics including the presence of MYC rearrangements and MYC-expression immunohistochemistry (IHC) at diagnosis and modalities of salvage therapy and their impact on the prognosis of patients between 61 and 80 years who had been treated on the RICOVER-60 trial. Results: TF-L occurred in 301 of the 1222 (24...
December 1, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29220684/predictors-of-remission-from-ptsd-symptoms-after-sexual-and-non-sexual-trauma-in-the-community-a-mediated-survival-analytic-approach
#13
Mario Müller, Vladeta Ajdacic-Gross, Stephanie Rodgers, Birgit Kleim, Erich Seifritz, Stefan Vetter, Stephan T Egger, Wulf Rössler, Enrique Castelao, Martin Preisig, Caroline Vandeleur
Epidemiological data on the chronicity of posttraumatic stress disorder (PTSD) symptoms in relation to trauma type and underlying pathways are rare. The current study explored how PTSD symptoms change over time across different trauma types and examined mediators of their persistence. A trauma-exposed community sample, whereof approximately one quarter met diagnostic criteria for PTSD, provided retrospective data on the duration of PTSD symptoms. Those who remitted and those who had not at the time of assessment were compared regarding worst trauma, symptom severity, comorbidity, demographic and treatment-seeking variables...
December 2, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29219593/first-dark-matter-search-results-from-the-xenon1t-experiment
#14
E Aprile, J Aalbers, F Agostini, M Alfonsi, F D Amaro, M Anthony, F Arneodo, P Barrow, L Baudis, B Bauermeister, M L Benabderrahmane, T Berger, P A Breur, A Brown, A Brown, E Brown, S Bruenner, G Bruno, R Budnik, L Bütikofer, J Calvén, J M R Cardoso, M Cervantes, D Cichon, D Coderre, A P Colijn, J Conrad, J P Cussonneau, M P Decowski, P de Perio, P Di Gangi, A Di Giovanni, S Diglio, G Eurin, J Fei, A D Ferella, A Fieguth, W Fulgione, A Gallo Rosso, M Galloway, F Gao, M Garbini, R Gardner, C Geis, L W Goetzke, L Grandi, Z Greene, C Grignon, C Hasterok, E Hogenbirk, J Howlett, R Itay, B Kaminsky, S Kazama, G Kessler, A Kish, H Landsman, R F Lang, D Lellouch, L Levinson, Q Lin, S Lindemann, M Lindner, F Lombardi, J A M Lopes, A Manfredini, I Mariş, T Marrodán Undagoitia, J Masbou, F V Massoli, D Masson, D Mayani, M Messina, K Micheneau, A Molinario, K Morå, M Murra, J Naganoma, K Ni, U Oberlack, P Pakarha, B Pelssers, R Persiani, F Piastra, J Pienaar, V Pizzella, M-C Piro, G Plante, N Priel, L Rauch, S Reichard, C Reuter, B Riedel, A Rizzo, S Rosendahl, N Rupp, R Saldanha, J M F Dos Santos, G Sartorelli, M Scheibelhut, S Schindler, J Schreiner, M Schumann, L Scotto Lavina, M Selvi, P Shagin, E Shockley, M Silva, H Simgen, M V Sivers, A Stein, S Thapa, D Thers, A Tiseni, G Trinchero, C Tunnell, M Vargas, N Upole, H Wang, Z Wang, Y Wei, C Weinheimer, J Wulf, J Ye, Y Zhang, T Zhu
We report the first dark matter search results from XENON1T, a ∼2000-kg-target-mass dual-phase (liquid-gas) xenon time projection chamber in operation at the Laboratori Nazionali del Gran Sasso in Italy and the first ton-scale detector of this kind. The blinded search used 34.2 live days of data acquired between November 2016 and January 2017. Inside the (1042±12)-kg fiducial mass and in the [5,40]  keV_{nr} energy range of interest for weakly interacting massive particle (WIMP) dark matter searches, the electronic recoil background was (1...
November 3, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29217238/feasibility-and-impact-of-focused-intraoperative-transthoracic-echocardiography-on-management-in-thoracic-surgery-patients-an-observational-study
#15
Thomas Kratz, Sarah Holz, Thorsten Steinfeldt, Maik Exner, Marco Campo dell'Orto, Caroline Kratz, Hinnerk Wulf, Martin Zoremba
OBJECTIVES: Intraoperative focused transthoracic echocardiography (TTE) is feasible and has an effect on the management of hemodynamically unstable surgical patients. Furthermore, in noncardiac thoracic surgery, TTE might provide additional information for hemodynamic treatment. Transthoracic accessibility during thoracic surgical interventions is assumed to be difficult. For patients positioned on their right side, a modified subcostal transthoracic view might be helpful. DESIGN: A prospective observational study...
September 9, 2017: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29214483/psychotherapyplus-augmentation-of-cognitive-behavioral-therapy-cbt-with-prefrontal-transcranial-direct-current-stimulation-tdcs-in-major-depressive-disorder-study-design-and-methodology-of-a-multicenter-double-blind-randomized-placebo-controlled-trial
#16
Malek Bajbouj, Sabine Aust, Jan Spies, Ana-Lucia Herrera-Melendez, Sarah V Mayer, Maike Peters, Christian Plewnia, Andreas J Fallgatter, Lukas Frase, Claus Normann, Nora Behler, Linda Wulf, Eva-Lotta Brakemeier, Frank Padberg
Major Depressive Disorder (MDD) is one of the most prevalent psychiatric disorders worldwide. About 20-30% of patients do not respond to the standard psychopharmacological and/or psychotherapeutic interventions. Mounting evidence from neuroimaging studies in MDD patients reveal altered activation patterns in lateral prefrontal brain areas. Successful cognitive behavioral therapy (CBT) is associated with a recovery of these neural alterations. Moreover, it has been demonstrated that transcranial direct current stimulation (tDCS) is capable of influencing prefrontal cortex activity and cognitive functions such as working memory and emotion regulation...
December 6, 2017: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/29203461/identifying-and-targeting-sporadic-oncogenic-genetic-aberrations-in-mouse-models-of-triple-negative-breast-cancer
#17
Hui Liu, Charles J Murphy, Florian A Karreth, Kristina B Emdal, Forest M White, Olivier Elemento, Alex Toker, Gerburg M Wulf, Lewis C Cantley
Triple negative breast cancers (TNBC) are genetically characterized by aberrations in TP53 and a low rate of activating point mutations in common oncogenes, rendering it challenging in applying targeted therapies. We performed whole exome sequencing (WES) and RNAseq to identify somatic genetic alterations in mouse models of TNBCs driven by loss of Trp53 alone or in combination with Brca1. Amplifications or translocations that resulted in elevated oncoprotein expressions or oncoprotein-containing fusions, respectively, as well as frame-shift mutations of tumor suppressors were identified in approximately 50% of the tumors evaluated...
December 4, 2017: Cancer Discovery
https://www.readbyqxmd.com/read/29189602/the-history-and-basic-science-development-of-soy-isoflavones
#18
Kenneth D R Setchell
This review summarizes the 2016 NAMS/Pfizer-Wulf H. Utian Endowed Lecture that focused on the history and basic science of soy isoflavones. Described is a personal perspective of the background and history that led to the current interest in soy and isoflavones with a specific focus on the role that soy isoflavones play in the health of postmenopausal women. This overview covers the metabolism and physiological behavior of isoflavones, their biological properties that are of potential relevance to aging, issues related to the safety of soy isoflavones, and the role of the important intestinally derived metabolite S-(-)equol...
November 20, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/29163906/biosynthesis-of-methyl-proline-containing-griselimycins-natural-products-with-anti-tuberculosis-activity
#19
Peer Lukat, Yohei Katsuyama, Silke Wenzel, Tina Binz, Claudia König, Wulf Blankenfeldt, Mark Brönstrup, Rolf Müller
Griselimycins (GMs) are depsidecapeptides with superb anti-tuberculosis activity. They contain up to three (2S,4R)-4-methyl-prolines (4-MePro), of which one blocks oxidative degradation and increases metabolic stability in animal models. The natural congener with this substitution is only a minor component in fermentation cultures. We showed that this product can be significantly increased by feeding the reaction with 4-MePro and we investigated the molecular basis of 4-MePro biosynthesis and incorporation...
November 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/29148315/sumoylation-in-brain-ischemia-patterns-targets-and-translational-implications
#20
Joshua D Bernstock, Wei Yang, Daniel G Ye, Yuntian Shen, Stefano Pluchino, Yang-Ja Lee, John M Hallenbeck, Wulf Paschen
Post-translational protein modification by small ubiquitin-like modifier (SUMO) regulates a myriad of homeostatic and stress responses. The SUMOylation pathway has been extensively studied in brain ischemia. Convincing evidence is now at hand to support the notion that a major increase in levels of SUMOylated proteins is capable of inducing tolerance to ischemic stress. Therefore, the SUMOylation pathway has emerged as a promising therapeutic target for neuroprotection in the face of brain ischemia. Despite this, it is prudent to acknowledge that there are many key questions still to be addressed in brain ischemia related to SUMOylation...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
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