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https://www.readbyqxmd.com/read/28720721/predictors-of-repeat-visits-to-hospital-psychiatric-emergency-departments-in-malaga-spain-and-in-lisbon-portugal
#1
Berta Moreno-Kã Stner, Ingeborg Warnke, Carlos Nordt, Gemma Fernandez, Josà Ramos, Pedro Paulino-Matos, Wulf Rössler, Graça Cardoso
OBJECTIVE: This study describes the profile of people with mental disorders attending emergency departments (EDs) in two countries and to identify specific mental disorders associated with repeat emergency visits. METHODS: Retrospective analyses of 1 year of EDs data from two hospitals with psychiatric departments, one in Amadora/Sintra (Lisbon, Portugal, 2008) and the other in Malaga (Spain, 2009), were carried out. To determine which mental disorders were associated with repeat visits in each setting, negative binomial models were calculated...
July 18, 2017: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/28720348/safety-evaluation-of-a-novel-muramidase-for-feed-application
#2
J Lichtenberg, E Perez Calvo, K Madsen, T Østergaard Lund, F Kramer Birkved, S van Cauwenberghe, M Mourier, L Wulf-Andersen, A J M Jansman, R Lopez-Ulibarri
Safety evaluation of a muramidase produced by a Trichoderma reesei strain (safe lineage), expressing a muramidase gene isolated from Acremonium alcalophilum is presented. Intended use in feed of this enzyme is as digestive aid in broiler chickens. Muramidase 007, was non-mutagenic and non-clastogenic in vitro, and no adverse effects were observed in 90-day subchronic toxicity studies in rats at doses up to 1132 mg TOS/kg body weight/day. The enzyme did not exhibit, in vitro, skin, nor eye irritation potential...
July 15, 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/28709045/enhancing-performance-expectancies-through-visual-illusions-facilitates-motor-learning-in-children
#3
Moslem Bahmani, Gabriele Wulf, Farhad Ghadiri, Saeed Karimi, Rebecca Lewthwaite
In a recent study by Chauvel, Wulf, and Maquestiaux (2015), golf putting performance was found to be affected by the Ebbinghaus illusion. Specifically, adult participants demonstrated more effective learning when they practiced with a hole that was surrounded by small circles, making it look larger, than when the hole was surrounded by large circles, making it look smaller. The present study examined whether this learning advantage would generalize to children who are assumed to be less sensitive to the visual illusion...
July 11, 2017: Human Movement Science
https://www.readbyqxmd.com/read/28701287/effects-of-sex-pregnancy-and-season-on-insulin-secretion-and-carbohydrate-metabolism-in-horses
#4
Elisabeth Beythien, Manuela Wulf, Natascha Ille, Jörg Aurich, Christine Aurich
In pregnant mares, peripheral insulin antagonism channels glucose preferentially to the foetus. On the other hand, horses reduce their metabolic activity in winter. Taking these aspects of equine pregnancy and metabolism together, we hypothesized that glucose clearance from blood and the insulin response to glucose do not only change throughout gestation but also with season. To test this hypothesis, the glucose and insulin response to an oral glucose test and relative insulin release were analysed in pregnant mares (n=12) and in geldings (n=10) as controls...
July 6, 2017: Animal Reproduction Science
https://www.readbyqxmd.com/read/28697044/to-the-editor
#5
Alain Bélanger, Wulf Utian
No abstract text is available yet for this article.
July 10, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28696202/animal-models-for-personalized-treatment-options
#6
Iduna Fichtner, Konrad Klinghammer, Diana Behrens, Susanne Flechsig, Jana Rolff, Michael Becker, Annika Wulf-Goldenberg, Maria Stecklum, Maria Rivera, Bernadette Brzezicha, Burkhard Jandrig, Jens Hoffmann
No abstract text is available yet for this article.
July 11, 2017: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28689410/new-aromatic-compounds-from-the-fruiting-body-of-sparassis-crispa-wulf-and-their-inhibitory-activities-on-pcsk9-mrna-expression
#7
Sunghee Bang, Hee-Sung Chae, Changyeol Lee, Hyun Gyu Choi, JiYoung Ryu, Wei Li, Hanna Lee, Gil-Saeng Jeong, Young-Won Chin, Sang Hee Shim
Repeated chromatography of the EtOAc-soluble fraction from the MeOH extract of the fruiting body of Sparassis crispa (Wulf.) led to isolation and determination of four new aromatic compounds, sparoside A, 1, and sparalides A-C, 3-5, two new naturally-occurring compounds, 2 and 6, as well as eight known compounds, 7-14. The chemical structures were determined by interpretation of spectroscopic data (NMR and MS). Extract, solvents-soluble fractions of the extract, and all the isolated compounds were evaluated for their inhibitory activities on mRNA expression of the proprotein convertase subtilisin/kexin type 9 (PCSK9)...
July 9, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28682946/cerebral-alterations-following-experimental-multiple-trauma-and-hemorrhagic-shock
#8
Nina Vogt, Christiane Herden, Elke Roeb, Martin Roderfeld, Daphne Eschbach, Thorsten Steinfeldt, Hinnerk Wulf, Steffen Ruchholtz, Eberhard Uhl, Karsten Schöller
Multiple trauma (MT) associated with hemorrhagic shock (HS) might lead to cerebral hypoperfusion and brain damage. We investigated cerebral alterations using a new porcine MT/HS model without traumatic brain injury (TBI) and assessed the neuroprotective properties of mild therapeutic hypothermia. Male pigs underwent standardized MT with HS (45% or 50% loss of blood volume) and resuscitation after 90/120 minutes (T90/T120). In additional groups (TH90/TH120) mild hypothermia (33°C) was induced following resuscitation...
July 4, 2017: Shock
https://www.readbyqxmd.com/read/28661484/sorafenib-tosylate-inhibits-directly-necrosome-complex-formation-and-protects-in-mouse-models-of-inflammation-and-tissue-injury
#9
Sofie Martens, Manhyung Jeong, Wulf Tonnus, Friederike Feldmann, Sam Hofmans, Vera Goossens, Nozomi Takahashi, Jan Hinrich Bräsen, Eun-Woo Lee, Pieter Van der Veken, Jurgen Joossens, Koen Augustyns, Simone Fulda, Andreas Linkermann, Jaewhan Song, Peter Vandenabeele
Necroptosis contributes to the pathophysiology of several inflammatory, infectious and degenerative disorders. TNF-induced necroptosis involves activation of the receptor-interacting protein kinases 1 and 3 (RIPK1/3) in a necrosome complex, eventually leading to the phosphorylation and relocation of mixed lineage kinase domain like protein (MLKL). Using a high-content screening of small compounds and FDA-approved drug libraries, we identified the anti-cancer drug Sorafenib tosylate as a potent inhibitor of TNF-dependent necroptosis...
June 29, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28660438/lower-material-stiffness-in-rupture-repaired-achilles-tendon-during-walking-transmission-mode-ultrasound-for-post-surgical-tendon-evaluation
#10
Mathias Wulf, Mihir Shanker, Michael Schuetz, Michael Lutz, Christian M Langton, Sue L Hooper, James E Smeathers, Torsten Brauner, Scott C Wearing
PURPOSE: This cross-sectional study used transmission-mode ultrasound to evaluate dynamic tendon properties during walking in surgically repaired and contralateral Achilles tendon (AT), with a median (range) post-operative period of 22 (4-58) months. It was hypothesised that the axial transmission speed of ultrasound (TSOU) during walking would be slower, indicating lower material stiffness in repaired compared with contralateral AT. METHODS: Ten patients [median (range) age 47 (37-69) years; height 180 (170-189) cm; weight 93 (62-119) kg], who had undergone open surgical repair of the AT and were clinically recovered according to their treating clinicians, walked barefoot on a treadmill at self-selected speed (1...
June 28, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28619701/effectiveness-of-a-web-based-intervention-in-reducing-depression-and-sickness-absence-randomized-controlled-trial
#11
Till Beiwinkel, Tabea Eißing, Nils-Torge Telle, Elisabeth Siegmund-Schultze, Wulf Rössler
BACKGROUND: Depression is highly prevalent in the working population and is associated with significant loss of workdays; however, access to evidence-based treatment is limited. OBJECTIVE: This study evaluated the effectiveness of a Web-based intervention in reducing mild to moderate depression and sickness absence. METHODS: In an open-label randomized controlled trial, participants were recruited from a large-scale statutory health insurance and were assigned to two groups...
June 15, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28609393/menopausal-transition-in-southern-europe-comparative-study-of-women-in-serbia-and-portugal
#12
Jelena Dotlic, Filipa Pimenta, Nikolina Kovacevic, Isabel Leal, Joao Maroco, Wulf Utian, Tatjana Gazibara
OBJECTIVE: The aim of this study was to assess and compare general menopausal quality of life in Serbia and Portugal. METHODS: In all, 1,503 women aged between 40 and 65 years from Belgrade, Serbia, and Lisbon, Portugal, were included in the study. A sociodemographic questionnaire and the Utian Quality of Life (UQOL) scale were used in data collection. RESULTS: The average age of women was 50 (SD = 5.61) years. Serbian and Portuguese women differed in all sociodemographic characteristics except for body mass index (BMI) and relationship status...
June 12, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28599980/generalized-hypermobility-knee-hyperextension-and-outcomes-after-anterior-cruciate-ligament-reconstruction-prospective-case-control-study-with-mean-6%C3%A2-years-follow-up
#13
Christopher M Larson, Asheesh Bedi, Mark E Dietrich, Jennifer C Swaringen, Corey A Wulf, David M Rowley, M Russell Giveans
PURPOSE: To determine whether generalized hypermobility and contralateral knee hyperextension affect failure rates and patient-related outcomes after anterior cruciate ligament reconstruction (ACLR). METHODS: A total of 226 consecutive patients presenting with acute ACL tears were prospectively evaluated for generalized hypermobility by a modified Beighton criteria. Minimum 2-year follow-up was achieved for 183 knees (81%). Patients underwent ACLR with either bone-patellar-tendon (BPTB) autograft (n = 46), quadrupled hamstring (HT) autograft (n = 85), or allograft tissue (n = 52)...
June 6, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/28586780/serum-levels-of-microrna371a-3p-a-highly-sensitive-tool-for-diagnosing-and-staging-testicular-germ-cell-tumours-a-clinical-case-series
#14
Petra Anheuser, Arlo Radtke, Christian Wülfing, Jennifer Kranz, Gazanfer Belge, Klaus-Peter Dieckmann
INTRODUCTION: MicroRNA (miR)371a-3p was suggested to be a sensitive and specific new serum biomarker of germ cell tumours (GCTs); however, its clinical usefulness remains unproven. PATIENTS, METHODS: In 312 consecutive cases with various testicular diseases, serum levels of miR371a-3p were measured. Measurement results became available only after completion of treatment. Five patients with testicular seminoma were selected for review because of unanticipated clinical courses...
June 7, 2017: Urologia Internationalis
https://www.readbyqxmd.com/read/28584430/the-benefit-of-benzodiazepine-reduction-improving-sedation-in-surgical-intensive-care
#15
Ralph Schneider, Andreas Puetz, Timon Vassiliou, Thomas Wiesmann, Ulrike Lewan, Hinnerk Wulf, Detlef K Bartsch, Caroline Rolfes
AIMS: Sedation, as it is often required in critical care, is associated with immobilization, prolonged ventilation, and increased morbidity. Most sedation protocols are based on benzodiazepines. The presented study analyzes the benefit of benzodiazepine-free sedation. METHODS: In 2008, 134 patients were treated according to a protocol using benzodiazepine and propofol (Group 1). In 2009, we introduced a new sedation strategy based on sufentanil, nonsteroidal anti-inflammatory drugs, neuroleptics, and antidepressants, which was applied in 140 consecutive patients (Group 2)...
May 2017: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/28583616/effects-of-season-on-placental-foetal-and-neonatal-development-in-horses
#16
Elisabeth Beythien, Christine Aurich, Manuela Wulf, Jörg Aurich
Seasonal changes in metabolic rate have been shown in horses and we hypothesized that this leads to the birth of smaller foals early in the year. Mares and their foals were assigned to three groups by day of foaling within the year (e.g. 1 January = day 1): Group 1 (n = 10) day 40-65, group 2 (n = 8) day 67-92, group 3 (n = 9) day 94-121. Groups did not differ with regard to parity. In foals, height at withers and body weight were determined on days 1-5 and weekly until 12 weeks of age. Chest circumference, distances fetlock to carpus, carpus to elbow, poll to nose and crown-rump length were determined on day 5 and weekly until 12 weeks of age...
July 15, 2017: Theriogenology
https://www.readbyqxmd.com/read/28574845/die-later-with-escrt
#17
EDITORIAL
Wulf Tonnus, Florian Gembardt, Christian Hugo, Andreas Linkermann
No abstract text is available yet for this article.
June 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28555120/psychotic-like-experiences-at-the-healthy-end-of-the-psychosis-continuum
#18
Lui Unterrassner, Thomas A Wyss, Diana Wotruba, Vladeta Ajdacic-Gross, Helene Haker, Wulf Rössler
There is increasing evidence pointing toward a continuous distribution of psychotic symptoms and accompanying factors between subclinical and clinical populations. However, for the construction of continuum models, a more detailed knowledge of different types of psychotic-like experiences (PLE) and their associations with distress, functional impairment, and demographic variables is needed. We investigated PLE in a sample of healthy adults (N = 206) incorporating the recently developed revised Exceptional Experiences Questionnaire (PAGE-R)...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28553287/hypoxia-modulates-the-response-of-mast-cells-to-staphylococcus-aureus-infection
#19
Helene Möllerherm, Katja Branitzki-Heinemann, Graham Brogden, Ayssar A Elamin, Wulf Oehlmann, Herbert Fuhrmann, Mahavir Singh, Hassan Y Naim, Maren von Köckritz-Blickwede
To study the antimicrobial function of immune cells ex vivo, cells are commonly cultivated under atmospheric oxygen concentrations (20-21%; normoxia), although the physiological oxygen conditions in vivo are significantly lower in most tissues. Especially during an acute infection, oxygen concentration locally decreases to hypoxic levels around or below 1%. The goal of this study was to investigate the effect of hypoxia on the activity of mast cells (MCs). MCs were cultivated for 3 or 24 h at 1% O2 in a hypoxia glove box and co-incubated with heat-inactivated Staphylococcus aureus...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28548643/condensed-versus-standard-schedule-of-high-dose-cytarabine-consolidation-therapy-with-pegfilgrastim-growth-factor-support-in-acute-myeloid-leukemia
#20
S Jaramillo, A Benner, J Krauter, H Martin, T Kindler, M Bentz, H R Salih, G Held, C-H Köhne, K Götze, M Lübbert, A Kündgen, P Brossart, M Wattad, H Salwender, B Hertenstein, D Nachbaur, G Wulf, H-A Horst, H Kirchen, W Fiedler, A Raghavachar, G Russ, S Kremers, E Koller, V Runde, G Heil, D Weber, G Göhring, K Döhner, A Ganser, H Döhner, R F Schlenk
The aim of this cohort study was to compare a condensed schedule of consolidation therapy with high-dose cytarabine on days 1, 2 and 3 (HDAC-123) with the HDAC schedule given on days 1, 3 and 5 (HDAC-135) as well as to evaluate the prophylactic use of pegfilgrastim after chemotherapy in younger patients with acute myeloid leukemia in first complete remission. One hundred and seventy-six patients were treated with HDAC-135 and 392 patients with HDAC-123 with prophylactic pegfilgrastim at days 10 and 8, respectively, in the AMLSG 07-04 and the German AML Intergroup protocol...
May 26, 2017: Blood Cancer Journal
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