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phosphatidylserine, brain

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https://www.readbyqxmd.com/read/27913277/specific-stabilization-of-cftr-by-phosphatidylserine
#1
Ellen Hildebrandt, Netaly Khazanov, John C Kappes, Qun Dai, Hanoch Senderowitz, Ina L Urbatsch
The Cystic Fibrosis Transmembrane Conductance Regulator (CFTR, ABCC7) is a plasma membrane chloride ion channel in the ABC transporter superfamily. CFTR is a key target for cystic fibrosis drug development, and its structural elucidation would advance those efforts. However, the limited in vivo and in vitro stability of the protein, particularly its nucleotide binding domains, has made structural studies challenging. Here we demonstrate that phosphatidylserine uniquely stimulates and thermally stabilizes the ATP hydrolysis function of purified human CFTR...
November 29, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27907021/the-effects-of-long-term-saturated-fat-enriched-diets-on-the-brain-lipidome
#2
Corey Giles, Ryusuke Takechi, Natalie A Mellett, Peter J Meikle, Satvinder Dhaliwal, John C Mamo
The brain is highly enriched in lipids, where they influence neurotransmission, synaptic plasticity and inflammation. Non-pathological modulation of the brain lipidome has not been previously reported and few studies have investigated the interplay between plasma lipid homeostasis relative to cerebral lipids. This study explored whether changes in plasma lipids induced by chronic consumption of a well-tolerated diet enriched in saturated fatty acids (SFA) was associated with parallel changes in cerebral lipid homeostasis...
2016: PloS One
https://www.readbyqxmd.com/read/27808224/changeover-from-signalling-to-energy-provisioning-lipids-during-transition-from-colostrum-to-mature-milk-in-the-giant-panda-ailuropoda-melanoleuca
#3
Tong Zhang, David G Watson, Rong Zhang, Rong Hou, I Kati Loeffler, Malcolm W Kennedy
Among the large placental mammals, ursids give birth to the most altricial neonates with the lowest neonatal:maternal body mass ratios. This is particularly exemplified by giant pandas. To examine whether there is compensation for the provision of developmentally important nutrients that other species groups may provide in utero, we examined changes in the lipids of colostrum and milk with time after birth in giant pandas. Lipids that are developmental signals or signal precursors, and those that are fundamental to nervous system construction, such as docosahexaenoic acid (DHA) and phosphatidylserines, appear early and then fall dramatically in concentration to a baseline at 20-30 days...
November 3, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27771897/profiling-of-signaling-proteins-in-penumbra-after-focal-photothrombotic-infarct-in-the-rat-brain-cortex
#4
Svetlana Demyanenko, Anatoly Uzdensky
In ischemic stroke, cell damage propagates from infarct core to surrounding tissue. To reveal proteins involved in neurodegeneration and neuroprotection, we explored the protein profile in penumbra surrounding the photothrombotic infarct core induced in rat cerebral cortex by local laser irradiation after Bengal Rose administration. Using antibody microarrays, we studied changes in expression of 224 signaling proteins 1, 4, or 24 h after photothrombotic infarct compared with untreated contralateral cortex...
October 22, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27388114/amelioration-of-scopolamine-induced-amnesia-by-phosphatidylserine-and-curcumin-in-the-day-old-chick
#5
Teresa A Barber, Edward M Edris, Paul J Levinsky, Justin M Williams, Ari R Brouwer, Shawn A Gessay
In the one-trial taste-avoidance task in day-old chicks, acetylcholine receptor activation has been shown to be important for memory formation. Injection of scopolamine produces amnesia, which appears to be very similar in type to that of Alzheimer's disease, which is correlated with low levels of acetylcholine in the brain. Traditional pharmacological treatments of Alzheimer's disease, such as cholinesterase inhibitors and glutamate receptor blockers, improve memory and delay the onset of impairments in memory compared with placebo controls...
September 2016: Behavioural Pharmacology
https://www.readbyqxmd.com/read/27231848/phosphatidylserine-targeted-liposome-for-enhanced-glioma-selective-imaging
#6
Liang Zhang, Amyn A Habib, Dawen Zhao
Phosphatidylserine (PS), which is normally intracellular, becomes exposed on the outer surface of viable endothelial cells (ECs) of tumor vasculature. Utilizing a PS-targeting antibody, we have recently established a PS-targeted liposomal (PS-L) nanoplatform that has demonstrated to be highly tumor-selective. Because of the vascular lumen-exposed PS that is immediately accessible without a need to penetrate the intact blood brain barrier (BBB), we hypothesize that the systemically administered PS-L binds specifically to tumor vascular ECs, becomes subsequently internalized into the cells and then enables its cargos to be efficiently delivered to glioma parenchyma...
June 21, 2016: Oncotarget
https://www.readbyqxmd.com/read/27220286/remodeling-of-lipid-bodies-by-docosahexaenoic-acid-in-activated-microglial-cells
#7
Marie-Eve Tremblay, Issan Zhang, Kanchan Bisht, Julie C Savage, Cynthia Lecours, Martin Parent, Vladimir Titorenko, Dusica Maysinger
BACKGROUND: Organelle remodeling processes are evolutionarily conserved and involved in cell functions during development, aging, and cell death. Some endogenous and exogenous molecules can modulate these processes. Docosahexaenoic acid (DHA), an omega-3 polyunsaturated fatty acid, has mainly been considered as a modulator of plasma membrane fluidity in brain development and aging, while DHA's role in organelle remodeling in specific neural cell types at the ultrastructural level remains largely unexplored...
2016: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/27170117/megf10-is-a-receptor-for-c1q-that-mediates-clearance-of-apoptotic-cells-by-astrocytes
#8
Tal Iram, Zaida Ramirez-Ortiz, Michael H Byrne, Uwanda A Coleman, Nathan D Kingery, Terry K Means, Dan Frenkel, Joseph El Khoury
UNLABELLED: Multiple EGF-like domains 10 (Megf10) is a class F scavenger receptor (SR-F3) expressed on astrocytes and myosatellite cells, and recessive mutations in humans result in early-onset myopathy, areflexia, respiratory distress, and dysphagia (EMARDD). Here we report that Megf10-deficient mice have increased apoptotic cells in the developing cerebellum and have impaired phagocytosis of apoptotic cells by astrocytes ex vivo We also report that cells transfected with Megf10 gain the ability to phagocytose apoptotic neurons and that Megf10 binds with high affinity to C1q, an eat-me signal for apoptotic cells...
May 11, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27160923/detection-of-cancer-cells-using-sapc-dops-nanovesicles
#9
REVIEW
Harold W Davis, Nida Hussain, Xiaoyang Qi
Unlike normal cells, cancer cells express high levels of phosphatidylserine on the extracellular leaflet of their cell membrane. Exploiting this characteristic, our lab developed a therapeutic agent that consists of the fusogenic protein, saposin C (SapC) which is embedded in dioleoylphosphatidylserine (DOPS) vesicles. These nanovesicles selectively target cancer cells and induce apoptosis. Here we review the data supporting use of SapC-DOPS to locate tumors for surgical resection or for treatment. In addition, there is important evidence suggesting that SapC-DOPS may also prove to be an effective novel cancer therapeutic reagent...
2016: Molecular Cancer
https://www.readbyqxmd.com/read/27096954/optical-and-nuclear-imaging-of-glioblastoma-with-phosphatidylserine-targeted-nanovesicles
#10
Víctor M Blanco, Zhengtao Chu, Kathleen LaSance, Brian D Gray, Koon Yan Pak, Therese Rider, Kenneth D Greis, Xiaoyang Qi
Multimodal tumor imaging with targeted nanoparticles potentially offers both enhanced specificity and sensitivity, leading to more precise cancer diagnosis and monitoring. We describe the synthesis and characterization of phenol-substituted, lipophilic orange and far-red fluorescent dyes and a simple radioiodination procedure to generate a dual (optical and nuclear) imaging probe. MALDI-ToF analyses revealed high iodination efficiency of the lipophilic reporters, achieved by electrophilic aromatic substitution using the chloramide 1,3,4,6-tetrachloro-3α,6α-diphenyl glycoluril (Iodogen) as the oxidizing agent in an organic/aqueous co-solvent mixture...
May 31, 2016: Oncotarget
https://www.readbyqxmd.com/read/27018635/efferocytosis-of-apoptotic-human-papillomavirus-positive-cervical-cancer-cells-by-human-primary-fibroblasts
#11
François Hermetet, Elise Jacquin, Sophie Launay, Emilie Gaiffe, Mélanie Couturier, Fabienne Hirchaud, Patrick Sandoz, Jean-Luc Prétet, Christiane Mougin
BACKGROUND INFORMATION: Efficient clearance of apoptotic cells, named efferocytosis, is a fundamental physiological process for tissue development and homeostasis. The contribution of non-professional phagocytes like fibroblasts to efferocytosis has been established, although the underlying mechanisms are not well understood. We recently demonstrated that horizontal DNA transfer can occur through the uptake of apoptotic human papillomavirus-positive cancer cells by human primary fibroblasts leading to their transformation...
July 2016: Biology of the Cell
https://www.readbyqxmd.com/read/26968097/dietary-dha-supplementation-causes-selective-changes-in-phospholipids-from-different-brain-regions-in-both-wild-type-mice-and-the-tg2576-mouse-model-of-alzheimer-s-disease
#12
Cécile Bascoul-Colombo, Irina A Guschina, Benjamin H Maskrey, Mark Good, Valerie B O'Donnell, John L Harwood
Alzheimer's disease (AD) is of major concern in ageing populations and we have used the Tg2576 mouse model to understand connections between brain lipids and amyloid pathology. Because dietary docosahexaenoic acid (DHA) has been identified as beneficial, we compared mice fed with a DHA-supplemented diet to those on a nutritionally-sufficient diet. Major phospholipids from cortex, hippocampus and cerebellum were separated and analysed. Each phosphoglyceride had a characteristic fatty acid composition which was similar in cortex and hippocampus but different in the cerebellum...
June 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/26960008/direct-affinity-of-dopamine-to-lipid-membranes-investigated-by-nuclear-magnetic-resonance-spectroscopy
#13
Yashasvi Matam, Bruce D Ray, Horia I Petrache
Dopamine, a naturally occurring neurotransmitter, plays an important role in the brain's reward system and acts on sensory receptors in the brain. Neurotransmitters are contained in lipid membraned vesicles and are released by exocytosis. All neurotransmitters interact with transport and receptor proteins in glial cells, on neuronal dendrites, and at the axonal button, and also must interact with membrane lipids. However, the extent of direct interaction between lipid membranes in the absence of receptors and transport proteins has not been extensively investigated...
April 8, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/26936867/getting-to-the-outer-leaflet-physiology-of-phosphatidylserine-exposure-at-the-plasma-membrane
#14
REVIEW
Edouard M Bevers, Patrick L Williamson
Phosphatidylserine (PS) is a major component of membrane bilayers whose change in distribution between inner and outer leaflets is an important physiological signal. Normally, members of the type IV P-type ATPases spend metabolic energy to create an asymmetric distribution of phospholipids between the two leaflets, with PS confined to the cytoplasmic membrane leaflet. On occasion, membrane enzymes, known as scramblases, are activated to facilitate transbilayer migration of lipids, including PS. Recently, two proteins required for such randomization have been identified: TMEM16F, a scramblase regulated by elevated intracellular Ca(2+), and XKR8, a caspase-sensitive protein required for PS exposure in apoptotic cells...
April 2016: Physiological Reviews
https://www.readbyqxmd.com/read/26924789/knockdown-of-zebrafish-yy1a-can-downregulate-the-phosphatidylserine-ps-receptor-expression-leading-to-induce-the-abnormal-brain-and-heart-development
#15
Wei-Lun Shiu, Kuan-Rong Huang, Jo-Chi Hung, Jen-Leih Wu, Jiann-Ruey Hong
BACKGROUND: Yin Yang 1 (YY1) is a ubiquitously expressed GLI-Kruppel zinc finger-containing transcriptional regulator. YY1 plays a fundamental role in normal biologic processes such as embryogenesis, differentiation, and cellular proliferation. YY1 effects on the genes involved in these processes are mediated via initiation, activation, or repression of transcription depending upon the context in which it binds. The role of the multifunctional transcription factor Yin Yang 1 (YY1) in tissue development is poorly understood...
2016: Journal of Biomedical Science
https://www.readbyqxmd.com/read/26858118/hydrophilic-interaction-liquid-chromatography-mass-spectrometry-of-lyso-phosphatidic-acids-lyso-phosphatidylserines-and-other-lipid-classes
#16
Eva Cífková, Roman Hájek, Miroslav Lísa, Michal Holčapek
The goal of this work is a systematic optimization of hydrophilic interaction liquid chromatography (HILIC) separation of acidic lipid classes (namely phosphatidic acids-PA, lysophosphatidic acids-LPA, phosphatidylserines-PS and lysophosphatidylserines-LPS) and other lipid classes under mass spectrometry (MS) compatible conditions. The main parameters included in this optimization are the type of stationary phases used in HILIC, pH of the mobile phase, the type and concentration of mobile phase additives. Nine HILIC columns with different chemistries (unmodified silica, modified silica using diol, 2-picolylamine, diethylamine and 1-aminoanthracene and hydride silica) are compared with the emphasis on peak shapes of acidic lipid classes...
March 25, 2016: Journal of Chromatography. A
https://www.readbyqxmd.com/read/26836183/cigarette-smoke-induced-alterations-in-frontal-white-matter-lipid-profiles-demonstrated-by-maldi-imaging-mass-spectrometry-relevance-to-alzheimer-s-disease
#17
Kavin Nunez, Jared Kay, Alexander Krotow, Ming Tong, Amit R Agarwal, Enrique Cadenas, Suzanne M de la Monte
BACKGROUND: Meta-analysis has shown that smokers have significantly increased risks for Alzheimer's disease (AD), and neuroimaging studies showed that smoking alters white matter (WM) structural integrity. OBJECTIVE: Herein, we characterize the effects of cigarette smoke (CS) exposures and withdrawal on WM myelin lipid composition using matrix assisted laser desorption and ionization-imaging mass spectrometry (MALDI-IMS). METHODS: Young adult male A/J mice were exposed to air (8 weeks; A8), CS (4 or 8 weeks; CS4, CS8), or CS8 followed by 2 weeks recovery (CS8 + R)...
2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/26707637/in%C3%A2-vivo-hmrs-and-lipidomic-profiling-reveals-comprehensive-changes-of-hippocampal-metabolism-during-aging-in-mice
#18
Lejun Lin, Bofeng Cao, Zhiying Xu, Yanbin Sui, Jiao Chen, Qiang Luan, Ruifang Yang, Shanchun Li, Ke Feng Li
Aging is characterized by various cellular changes in the brain. Hippocampus is important for systemic aging and lifespan control. There is still a lack of comprehensive overview of metabolic changes in hippocampus during aging. In this study, we first created an accelerated brain aging mice model through the chronic administration of d-galactose. We then performed a multiplatform metabolomic profiling of mice hippocampus using the combination of in vivo 9.4 T HMRS and in vitro LC-MS/MS based lipidomics...
January 29, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/26689775/synergy-between-phenotypic-modulation-and-ros-neutralization-in-reduction-of-inflammatory-response-of-hypoxic-microglia-by-using-phosphatidylserine-and-antioxidant-containing-liposomes
#19
Md Zahangir Hosain, Takeshi Mori, Akihiro Kishimura, Yoshiki Katayama
Neuroinflammation caused by microglial activation is a key contributing factor in neurological disorders such as those involving ischaemia. Excess production of reactive oxygen species (ROS) and nitric oxide (NO) stimulates the inflammatory response during ischaemia, significantly damaging cells. Inhibition of inflammatory activation of microglia is a promising potential treatment approach for neurological diseases. In this study, we introduce α-tocopherol and phosphatidylserine (PS) containing liposomes (PST-liposomes) to inhibit the microglial inflammatory response...
2016: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/26606074/protective-effects-of-dietary-supplementation-with-a-combination-of-nutrients-in-a-transgenic-mouse-model-of-alzheimer-s-disease
#20
Shengyuan Wang, Yu Cui, Yu Cu, Chao Wang, Wei Xie, Lan Ma, Jinfeng Zhu, Yan Zhang, Rui Dang, Decai Wang, Yonghui Wu, Qunhong Wu
OBJECTIVE: This study investigated the effects of intervention with a combination of nutrients in the amyloid precursor protein-presenilin (APP-PSN) C57BL/6J double transgenic mouse model of Alzheimer's disease (AD). METHODS: A total of 72 2-month-old APP-PSN mice were randomly assigned to three groups. The model group (MG) was fed regular, unsupplemented chow, while the low- and high-dose treatment groups (LG and HG, respectively) were given a combination of nutrients that included phosphatidylserine, blueberry extracts, docosahexaenoic acid, and eicosapentaenoic acid as part of their diet...
2015: PloS One
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