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AVPR1A

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https://www.readbyqxmd.com/read/27910885/bonobo-personality-traits-are-heritable-and-associated-with-vasopressin-receptor-gene-1a-variation
#1
Nicky Staes, Alexander Weiss, Philippe Helsen, Marisa Korody, Marcel Eens, Jeroen M G Stevens
Despite being closely related, bonobos and chimpanzees show remarkable behavioral differences, the proximate origins of which remain unknown. This study examined the link between behavioral variation and variation in the vasopressin 1a receptor gene (Avpr1a) in bonobos. Chimpanzees are polymorphic for a ~360 bp deletion (DupB), which includes a microsatellite (RS3) in the 5' promoter region of Avpr1a. In chimpanzees, the DupB deletion has been linked to lower sociability, lower social sensitivity, and higher anxiety...
December 2, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27874273/association-testing-of-vasopressin-receptor-1a-microsatellite-polymorphisms-in-non-clinical-autism-spectrum-phenotypes
#2
Tanya L Procyshyn, Peter L Hurd, Bernard J Crespi
Variation in the arginine vasopressin receptor 1a (AVPR1a) gene is associated with autism risk in clinical populations and with variation in social behavior in non-clinical populations. However, whether a relationship exists between AVPR1a polymorphisms and non-clinical manifestations of autism spectrum phenotypes has not been established. In this study, 873 Caucasian university students were administered the Autism-spectrum Quotient (AQ) questionnaire and genotyped for the RS1 and RS3 microsatellites. A significant association was found between RS3 microsatellite variation and AQ score, with the long/long RS3 genotype associated with higher AQ score...
November 22, 2016: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/27858316/clinical-outcomes-linked-to%C3%A2-expression%C3%A2-of-gene-subsets-for-protein-hormones-and-their-cognate-receptors-from-lcm-procured-breast%C3%A2-carcinoma-cells
#3
Michael W Daniels, Guy N Brock, James L Wittliff
PURPOSE: Certain peptide hormones and/or their cognate receptors influencing normal cellular pathways also have been detected in breast cancers. The hypothesis is that gene subsets of these regulatory molecules predict risk of breast carcinoma recurrence in patients with primary disease. METHODS: Gene expression levels of 61 hormones and 81 receptors were determined by microarray with LCM-procured carcinoma cells of 247 de-identified biopsies. Univariable and multivariable Cox regressions were determined using expression levels of each hormone/receptor gene, individually or as a pair...
November 17, 2016: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/27804047/chimpanzee-personality-and-the-arginine-vasopressin-receptor-1a-genotype
#4
V A D Wilson, A Weiss, T Humle, N Morimura, T Udono, G Idani, T Matsuzawa, S Hirata, M Inoue-Murayama
Polymorphisms of the arginine vasopressin receptor 1a (AVPR1a) gene have been linked to various measures related to human social behavior, including sibling conflict and agreeableness. In chimpanzees, AVPR1a polymorphisms have been associated with traits important for social interactions, including sociability, joint attention, dominance, conscientiousness, and hierarchical personality dimensions named low alpha/stability, disinhibition, and negative emotionality/low dominance. We examined associations between AVPR1a and six personality domains and hierarchical personality dimensions in 129 chimpanzees (Pan troglodytes) living in Japan or in a sanctuary in Guinea...
November 2, 2016: Behavior Genetics
https://www.readbyqxmd.com/read/27743766/genetic-variants-in-oxytocin-receptor-and-arginine-vasopressin-receptor-1a-are-associated-with-the-neural-correlates-of-maternal-and-paternal-affection-towards-their-child
#5
Shota Nishitani, Kazuya Ikematsu, Tsunehiko Takamura, Sumihisa Honda, Koh-Ichiro Yoshiura, Kazuyuki Shinohara
There is extensive evidence in animal studies, particularly in vole species (Microtus), that oxytocin (OT) receptor and arginine-vasopressin (AVP) receptor 1a is critical for the regulation of maternal and paternal behavior, respectively. Human studies have gained insight into the relationship between both hormone receptor gene variants and behavior, but not between the variants and the underlying brain activity. To study this, we investigated the association between neural activation of the anterior prefrontal cortex (APFC) in mothers and fathers in response to their child smiling video stimuli to induce the positive affect related to attachment with their child, and genetic variants of OT receptor (OXTR) and AVP receptor 1A (AVPR1A)...
October 13, 2016: Hormones and Behavior
https://www.readbyqxmd.com/read/27717050/transient-and-persistent-behavioral-and-molecular-changes-in-primiparous-female-wistar-rats
#6
Roshan R Naik, Trynke R de Jong
Motherhood brings about a multitude of behavioral and physiological changes in dams and some of these persist until after weaning. We studied behavioral changes associated with reproductive experience at lactating day (LD)8, at weaning (LD21), and 28 days post-weaning (PW28) compared to nulliparous (NP) females. Furthermore, in another cohort of animals, we quantified mRNA expression of five target genes known to be associated with maternal experience: arginin-vasopressin(Avp) and its 1A receptor(Avpr1a), oxytocin(Oxt) and its receptor(Oxtr), and corticotropin-releasing hormone(Crh) in three key maternal region: the medial preoptic area (MPOA), bed nucleus of the stria terminalis (BNST) and paraventricular hypothalamic nucleus(PVN)...
September 26, 2016: European Journal of Neuroscience
https://www.readbyqxmd.com/read/27697521/activation-of-arginine-vasopressin-receptor-1a-facilitates-the-induction-of-long-term-potentiation-in-the-accessory-olfactory-bulb-of-male-mice
#7
Toshiharu Namba, Mutsuo Taniguchi, Yoshihiro Murata, Jia Tong, Yujie Wang, Fumino Okutani, Masahiro Yamaguchi, Hideto Kaba
Olfaction plays an important role in social recognition in most mammals. Central arginine vasopressin (AVP) plays a role in this olfaction-based recognition. The high level of expression of AVP receptors in the accessory olfactory bulb (AOB) at the first relay of the vomeronasal system highlights the importance of AVP signaling at this stage. We therefore analyzed the effects of AVP on the synaptic plasticity of glutamatergic transmission from mitral cells to granule cells in AOB slices from male mice. To monitor the strength of the glutamatergic transmission, we measured the maximal initial slope of the lateral olfactory tract-evoked field potential, which represents the granule cell response to mitral cell activation...
September 30, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/27581946/variation-in-mothers-arginine-vasopressin-receptor-1a-and-dopamine-receptor-d4-genes-predicts-maternal-sensitivity-via-social-cognition
#8
E M Leerkes, J Su, S Calkins, V C Henrich, A Smolen
We examined the extent to which the arginine vasopressin receptor 1a (AVPR1a) and dopamine receptor D4 (DRD4) were related to sensitive maternal behavior directly or indirectly via maternal social cognition. Participants were 207 (105 European-American and 102 African-American) mothers and their children (52% females). Sensitive maternal behavior was rated and aggregated across a series of tasks when infants were 6 months, 1 year and 2 years old. At 6 months, mothers were interviewed about their empathy, attributions about infant behavior and beliefs about crying to assess their parenting-related social cognition...
September 1, 2016: Genes, Brain, and Behavior
https://www.readbyqxmd.com/read/27556112/impaired-social-cognition-processes-in-asperger-syndrome-and-anorexia-nervosa-in-search-for-endophenotypes-of-social-cognition
#9
REVIEW
Beata Joanna Kasperek-Zimowska, Janusz Grzegorz Zimowski, Katarzyna Biernacka, Katarzyna Kucharska-Pietura, Filip Rybakowski
A growing number of publications indicates presence of significant deficits in social cognition in patients with anorexia nervosa (AN). These deficits appear to be comparable in qualitative and quantitative dimension with impairment of the same functions among people with Asperger syndrome (AS). The aim of this study is to identify subject areas in the field of impairment of social cognition processes among people with Asperger syndrome and anorexia nervosa taking into consideration the potential contribution of genetic pathways of oxytocin and vasopressin in the pathogenesis of these diseases...
2016: Psychiatria Polska
https://www.readbyqxmd.com/read/27525673/chronic-postnatal-stress-induces-depressive-like-behavior-in-male-mice-and-programs-second-hit-stress-induced-gene-expression-patterns-of-oxtr-and-avpr1a-in-adulthood
#10
Alexandra Lesse, Kathy Rether, Nicole Gröger, Katharina Braun, Jörg Bock
Chronic stress (CS) during early life represents a major risk factor for the development of mental disorders, including depression. According to the Two/Multiple-Hit hypothesis, the etiology of neuropsychiatric disorders usually involves multiple stressors experienced subsequently during different phases of life. However, the molecular and cellular mechanisms modulating neuronal and behavioral changes induced by multiple stress experiences are just poorly understood. Since the oxytocinergic and vasopressinergic systems are neuroendocrine modulators involved in environmentally driven adaptations of stress sensitivity we hypothesized that postnatal CS programs oxytocinergic and vasopressinergic receptor expression changes in response to a second stress exposure in young adulthood...
August 15, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27505307/oxytocin-and-arginine-vasopressin-receptor-evolution-implications-for-adaptive-novelties-in-placental-mammals
#11
Pamela Paré, Vanessa R Paixão-Côrtes, Luciana Tovo-Rodrigues, Pedro Vargas-Pinilla, Lucas Henriques Viscardi, Francisco Mauro Salzano, Luiz E Henkes, Maria Catira Bortolini
Oxytocin receptor (OXTR) and arginine vasopressin receptors (AVPR1a, AVPR1b, and AVPR2) are paralogous genes that emerged through duplication events; along the evolutionary timeline, owing to speciation, numerous orthologues emerged as well. In order to elucidate the evolutionary forces that shaped these four genes in placental mammals and to reveal specific aspects of their protein structures, 35 species were selected. Specifically, we investigated their molecular evolutionary history and intrinsic protein disorder content, and identified the presence of short linear interaction motifs...
August 8, 2016: Genetics and Molecular Biology
https://www.readbyqxmd.com/read/27497314/variation-in-the-oxytocin-receptor-gene-oxtr-is-associated-with-differences-in-moral-judgment
#12
Regan M Bernhard, Jonathan Chaponis, Richie Siburian, Patience Gallagher, Katherine Ransohoff, Daniel Wikler, Roy H Perlis, Joshua D Greene
Moral judgments are produced through the coordinated interaction of multiple neural systems, each of which relies on a characteristic set of neurotransmitters. Genes that produce or regulate these neurotransmitters may have distinctive influences on moral judgment. Two studies examined potential genetic influences on moral judgment using dilemmas that reliably elicit competing automatic and controlled responses, generated by dissociable neural systems. Study 1 (N = 228) examined 49 common variants (SNPs) within 10 candidate genes and identified a nominal association between a polymorphism (rs237889) of the oxytocin receptor gene (OXTR) and variation in deontological vs...
August 6, 2016: Social Cognitive and Affective Neuroscience
https://www.readbyqxmd.com/read/27350097/genetic-influences-on-conduct-disorder
#13
Jessica E Salvatore, Danielle M Dick
Conduct disorder (CD) is a moderately heritable psychiatric disorder of childhood and adolescence characterized by aggression toward people and animals, destruction of property, deceitfulness or theft, and serious violation of rules. Genome-wide scans using linkage and association methods have identified a number of suggestive genomic regions that are pending replication. A small number of candidate genes (e.g., GABRA2, MAOA, SLC6A4, AVPR1A) are associated with CD related phenotypes across independent studies; however, failures to replicate also exist...
June 24, 2016: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/27083501/male-prairie-voles-with-different-avpr1a-microsatellite-lengths-do-not-differ-in-courtship-behaviour
#14
Brittney M Graham, Nancy G Solomon, Douglas A Noe, Brian Keane
Females are generally expected to be selective when choosing their social and sexual partners. In a previous laboratory study, female prairie voles (Microtus ochrogaster) showed significant social and sexual preferences for males with longer microsatellite DNA within the avpr1a gene encoding the vasopressin 1a receptor, as predicted if females select mates whose parental behaviour should increase female reproductive success. We tested the hypothesis that males with short versus long avpr1a microsatellite alleles exhibit differences in courtship behaviour, which could act as cues for female mate preference...
July 2016: Behavioural Processes
https://www.readbyqxmd.com/read/27068699/diurnal-regulation-of-hypothalamic-kisspeptin-is-disrupted-during-mouse-pregnancy
#15
Cassandra C Yap, Michaela D Wharfe, Peter J Mark, Brendan J Waddell, Jeremy T Smith
Kisspeptin, the neuropeptide product of the Kiss1 gene, is critical in driving the hypothalamic-pituitary-gonadal (HPG) axis. Kisspeptin neurons in the anteroventral periventricular nucleus (AVPV) and arcuate nucleus (Arc) of the hypothalamus mediate differential effects, with the Arc regulating negative feedback of sex steroids and the AVPV regulating positive feedback, vital for the preovulatory surge and gated under circadian control. We aimed to characterize hypothalamic Kiss1 and Kiss1r mRNA expression in nonpregnant and pregnant mice, and investigate potential circadian regulation...
June 2016: Journal of Endocrinology
https://www.readbyqxmd.com/read/27058969/the-influence-of-avpr1a-genotype-on-individual-differences-in-behaviors-during-a-mirror-self-recognition-task-in-chimpanzees-pan-troglodytes
#16
L M Mahovetz, L J Young, W D Hopkins
The mark/rouge test has been used to assess mirror self-recognition (MSR) in many species. Despite consistent evidence of MSR in great apes, genetic or non-genetic factors may account for the individual differences in behavioral responses that have been reported. We examined whether vasopressin receptor gene (AVPR1A) polymorphisms are associated with MSR-related behaviors in chimpanzees since vasopressin has been implicated in the development and evolution of complex social relations and cognition and chimpanzees are polymorphic for the presence of the RS3-containing DupB region...
June 2016: Genes, Brain, and Behavior
https://www.readbyqxmd.com/read/27037495/role-of-enteroendocrine-l-cells-in-arginine-vasopressin-mediated-inhibition-of-colonic-anion-secretion
#17
Ramona Pais, Juraj Rievaj, Claire Meek, Gayan De Costa, Samanthie Jayamaha, R Todd Alexander, Frank Reimann, Fiona Gribble
KEY POINTS: Arginine vasopressin (AVP) stimulates the release of enteroendocrine L-cell derived hormones glucagon-like peptide-1 (GLP-1) and peptide YY (PYY) in vitro from mouse and human colons. This is mediated by the AVP receptor 1B, which is highly enriched in colonic L-cells and linked to the elevation of L-cell calcium and cAMP concentrations. By means of Ussing chambers, we show that AVP reduced colonic anion secretion, although this was blocked by a specific neuropeptide Y receptor Y1 receptor antagonist, suggesting that L-cell-released PYY acts locally on the epithelium to modulate fluid balance...
September 1, 2016: Journal of Physiology
https://www.readbyqxmd.com/read/27027249/sex-specific-mediation-effect-of-the-right-fusiform-face-area-volume-on-the-association-between-variants-in-repeat-length-of-avpr1a-rs3-and-altruistic-behavior-in-healthy-adults
#18
Junping Wang, Wen Qin, Feng Liu, Bing Liu, Yuan Zhou, Tianzi Jiang, Chunshui Yu
Microsatellite variants in the arginine vasopressin receptor 1A gene (AVPR1A) RS3 have been associated with normal social behaviors variation and autism spectrum disorders (ASDs) in a sex-specific manner. However, neural mechanisms underlying these associations remain largely unknown. We hypothesized that AVPR1A RS3 variants affect altruistic behavior by modulating the gray matter volume (GMV) of specific brain regions in a sex-specific manner. We investigated 278 young healthy adults using the Dictator Game to assess altruistic behavior...
July 2016: Human Brain Mapping
https://www.readbyqxmd.com/read/26945673/biopsychosocial-influence-on-shoulder-pain-influence-of-genetic-and-psychological-combinations-on-twelve-month-postoperative-pain-and-disability-outcomes
#19
Steven Z George, Samuel S Wu, Margaret R Wallace, Michael W Moser, Thomas W Wright, Kevin W Farmer, Warren H Greenfield, Yunfeng Dai, Hua Li, Roger B Fillingim
OBJECTIVE: To identify novel combinations of genetic and psychological factors that predicted 12-month postoperative pain and disability outcomes following arthroscopic shoulder surgery. METHODS: A prospective presurgical cohort (n = 150) was recruited to complete validated psychological questionnaires and have their DNA collected from saliva. DNA was genotyped for a priori selected genes involved with pain modulation (ADRB2, OPRM1, AVPR1A, GCH1, and KCNS1) and inflammation (IL1B, TNF/LTA, and IL6)...
November 2016: Arthritis Care & Research
https://www.readbyqxmd.com/read/26911439/selective-localization-of-oxytocin-receptors-and-vasopressin-1a-receptors-in-the-human-brainstem
#20
Sara M Freeman, Aaron L Smith, Mark M Goodman, Karen L Bales
Intranasal oxytocin affects a suite of human social behaviors, including trust, eye contact, and emotion recognition. However, it is unclear where oxytocin receptors (OXTR) and the structurally related vasopressin 1a receptors (AVPR1a) are expressed in the human brain. We have previously described a reliable, pharmacologically informed receptor autoradiography protocol for visualizing these receptors in postmortem primate brain tissue. We used this technique in human brainstem tissue to identify the neural targets of oxytocin and vasopressin...
February 25, 2016: Social Neuroscience
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