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https://www.readbyqxmd.com/read/29329323/stroke-risk-and-outcomes-in-patients-with-chronic-kidney-disease-or-end-stage-renal-disease-two-nationwide-studies
#1
Yih-Giun Cherng, Chao-Shun Lin, Chun-Chuan Shih, Yung-Ho Hsu, Chun-Chieh Yeh, Chaur-Jong Hu, Ta-Liang Chen, Chien-Chang Liao
BACKGROUND AND AIMS: Because the risk and outcomes of stroke in patients with chronic kidney disease (CKD) or end-stage renal disease (ESRD) were unclear, we evaluated these risks using a retrospective cohort study and a nested cohort study. METHODS: We used Taiwan's National Health Insurance Research Database to identify 1378 patients aged ≥20 years who had ESRD in 2000-2004. An age- and sex-matched CKD cohort (n = 5512) and a control cohort (n = 11,024) were selected for comparison...
2018: PloS One
https://www.readbyqxmd.com/read/29327353/increased-risk-of-congestive-heart-failure-in-patients-with-acetaminophen-poisoning-a-nationwide-cohort-study
#2
Wei-Sheng Chung, Cheng-Li Lin
Acetaminophen poisoning increases cytochrome P450 2E1 expression and reactive oxygen species production, which may lead to maladaptive myocardial remodeling and congestive heart failure (CHF). We conducted a nationwide cohort study to investigate the incidence and risk of CHF in patients with acetaminophen poisoning. We identified a cohort of adult patients with newly diagnosed acetaminophen poisoning in the inpatient claims of the Taiwan National Health Insurance Research Database for the 1998-2011 period...
January 11, 2018: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/29325919/patients-with-cerebral-stroke-have-an-increased-risk-of-gastroesophageal-reflux-disease-a-population-based-cohort-study
#3
Chen-Shu Chang, Hsuan-Ju Chen, Chun-Hui Liao
BACKGROUND: Medical complications following stroke often result in significant morbidity. This study was designed to investigate the prevalence and risk of gastroesophageal reflux disease (GERD) between patients with stroke and those without stroke in Taiwan. METHODS AND RESULTS: This retrospective cohort study was conducted using the Taiwan National Health Insurance Research Database. The study included 18,412 patients newly diagnosed as having stroke during 2000-2006 and 18,412 patients without stroke frequency-matched by sex, age, and index year...
January 8, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29325484/risk-of-erectile-dysfunction-after-traumatic-brain-injury-a-nationwide-population-based-cohort-study-in-taiwan
#4
Yun-Ju Yang, Wu-Chien Chien, Chi-Hsiang Chung, Kun-Ting Hong, Yi-Lin Yu, Dueng-Yuan Hueng, Yuan-Hao Chen, Hsin-I Ma, Hsin-An Chang, Yu-Chen Kao, Hui-Wen Yeh, Nian-Sheng Tzeng
INTRODUCTION: In our study, we aimed to investigate the association between a traumatic brain injury (TBI) and subsequent erectile dysfunction (ED). This is a population-based study using the claims dataset from The National Health Insurance Research Database. METHODS: We included 72,642 patients with TBI aged over 20 years, retrospectively, selected from the longitudinal health insurance database during 2000-2010, according to the ICD-9-CM. The control group consisted of 217,872 patients without TBI that were randomly chosen from the database at a ratio of 1:3, with age- and index year matched...
January 1, 2018: American Journal of Men's Health
https://www.readbyqxmd.com/read/29324771/impact-of-grouping-complications-on-mortality-in-traumatic-brain-injury-a-nationwide-population-based-study
#5
Chung-Han Ho, Fu-Wen Liang, Jhi-Joung Wang, Chung-Ching Chio, Jinn-Rung Kuo
Traumatic brain injury (TBI) is an important health issue with high mortality. Various complications of physiological and cognitive impairment may result in disability or death after TBI. Grouping of these complications could be treated as integrated post-TBI syndromes. To improve risk estimation, grouping TBI complications should be investigated, to better predict TBI mortality. This study aimed to estimate mortality risk based on grouping of complications among TBI patients. Taiwan's National Health Insurance Research Database was used in this study...
2018: PloS One
https://www.readbyqxmd.com/read/29321482/enhanced-yap-expression-leads-to-egfr-tki-resistance-in-lung-adenocarcinomas
#6
Ting-Fang Lee, Yu-Chi Tseng, Phung Anh Nguyen, Yu-Chuan Li, Chao-Chi Ho, Cheng-Wen Wu
Epidermal growth factor receptor (EGFR) mutation is prevalently expressed in lung adenocarcinoma cases and acts as one of the major driving oncogenes. EGFR tyrosine kinase inhibitors (TKIs) have been used in patients with EGFR-mutant as an effective targeted therapy in lung adenocarcinoma, but drug resistance and tumor recurrence inevitably occurs. Recently, Yes-associate protein (YAP) has been reported to promote multiple cancer cell properties, such as promoting cell proliferation, epithelial-mesenchymal transition and drug resistance...
January 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29316009/excess-incidence-and-risk-factors-for-recurrent-pneumonia-in-bipolar-disorder
#7
Min-Shan Li, Galen Chin-Lun Hung, Shu-Yu Yang, Chun-Hung Pan, Ya-Tang Liao, Shang-Ying Tsai, Chiao-Chicy Chen, Chian-Jue Kuo
AIM: Patients with bipolar disorder had poorer outcomes after pneumonia and could have a higher risk for recurrence of pneumonia. We aimed to investigate the incidence and risk factors of recurrent pneumonia in patients with bipolar disorder. METHODS: In a nationwide cohort of bipolar patients (derived from the National Health Insurance Research Database in Taiwan) who were hospitalized for pneumonia between 1996 and 2012, we identified 188 patients who developed recurrent pneumonia after a baseline pneumonia episode...
January 8, 2018: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/29315204/moral-distress-model-reconstructed-using-grounded-theory
#8
Hsun-Kuei Ko, Chi-Chun Chin, Min-Tao Hsu
BACKGROUND: The problems of nurse burnout and manpower shortage relate to moral distress. Thus, having a good understanding of moral distress is critical to developing strategies that effectively improve the clinical ethical climate and improve nursing retention in Taiwan. PURPOSE: The aim of this study was to reconstruct the model of moral distress using the grounded theory. METHODS: Twenty-five staff nurses at work units who attend to the needs of adult, pediatric, acute, and critical disease or end-of-life-care patients were recruited as participants using theoretical sampling from three teaching hospitals in Taiwan...
February 2018: Journal of Nursing Research: JNR
https://www.readbyqxmd.com/read/29315158/increased-incidence-of-obstructive-sleep-apnea-in-hospitalized-children-following-enterovirus-infection-a-nationwide-population-based-cohort-study
#9
Vincent Chin-Hung Chen, Yao-Hsu Yang, Ting-Yu Kuo, Kuo-You Huang, Yin-Cheng Huang, Yena Lee, Roger S McIntyre, Yu-Shu Huang, Chung-Yao Hsu
BACKGROUND: We report the first nationwide population-based cohort study using Taiwan's National Health Insurance Research Database on the association between enterovirus infection and the incidence of sleep disorders in a pediatric population. METHODS: Two matched groups of children under 18 years of age were included in the analyses for non-apneic sleep disorder and obstructive sleep apnea (OSA). Among them, 316 subjects were diagnosed with OSA during the surveillance period, including 182 in the EV infection group and 134 in the non-EV infection group...
January 8, 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29314287/association-of-between-obstructive-sleep-apnea-and-atopic-dermatitis-in-children-a-nationwide-population-based-cohort-study
#10
Je-Ming Hu, Chin-Sheng Lin, Sy-Jou Chen, Chao-Yang Chen, Cheng-Li Lin, Chia-Hung Kao
BACKGROUND: Atopic dermatitis (AD) is associated with systemic inflammation and may have a similar pathogenesis as obstructive sleep apnea (OSA). However, to date, studies on the association between AD and OSA is limited. OBJECTIVES: This study evaluated the association between OSA and AD in children in a large-scale, population-based cohort. METHODS: A total of approximately 120,736 children (<18 years) with newly diagnosed AD and 120,736 age- and sex-matched patients without AD from 2000 to 2007 were identified from Taiwan's National Health Insurance Research Database from 2000 to 2007...
January 4, 2018: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/29306884/retrospective-cohort-study-on-risk-of-hearing-loss-in-patients-with-rheumatoid-arthritis-using-claims-data
#11
Chung-Ming Huang, Hsuan-Ju Chen, Po-Hao Huang, Gregory J Tsay, Joung-Liang Lan, Fung-Chang Sung
OBJECTIVES: Population studies on hearing loss (HL) associated with rheumatoid arthritis (RA) are lacking. This study investigated the risk of developing HL in patients with RA using a nationwide population cohort. SETTING: The population-based insurance claims data in the Taiwan National Health Insurance Research Database. DESIGN: Retrospective cohort study followed up RA cohort and control cohort without RA frequency matched by sex, age and diagnosis year...
January 5, 2018: BMJ Open
https://www.readbyqxmd.com/read/29306696/evaluating-clinical-risk-factors-for-suicide-attempts-in-patients-with-epilepsy
#12
Tomor Harnod, Cheng-Li Lin, Chia-Hung Kao
OBJECTIVE: We would like to exam whether epilepsy patients in Taiwan have a high risk of attempted and completed suicide. METHODS: In this study, we used a subset of the National Health Insurance Research Database (NHIRD) of Taiwan. Inpatients (≥ 18 years) who received a new diagnosis of epilepsy between 2000 and 2011 were enrolled in the epilepsy cohort. The epilepsy and comparison cohorts included 68,543 patients and 2-fold controls respectively. We calculated the adjusted hazard ratio (aHR) for suicide attempts after adjustment for age, sex, monthly income, the urbanization level, occupation, and comorbidity...
December 29, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29304527/is-there-a-preferred-stroke-prevention-strategy-for-diabetic-patients-with-non-valvular-atrial-fibrillation-comparing-warfarin-dabigatran-and-rivaroxaban
#13
Chih-Cheng Hsu, Pai-Feng Hsu, Shih-Hsien Sung, Shih-Te Tu, Ben-Hui Yu, Chi-Jung Huang, Hao-Min Cheng
BACKGROUND:  The prevalence of diabetes is growing, and diabetes is an independent risk factor for both atrial fibrillation (AF) and stroke. However, the relative effectiveness and safety of different oral anticoagulants for diabetic patients with non-valvular AF remain unclear. We aimed to compare thromboembolic events, bleeding and mortality in diabetic AF patients treated with rivaroxaban, dabigatran and warfarin. METHODS AND RESULTS:  Diabetic AF patients taking dabigatran (n = 322), rivaroxaban (n = 320) or warfarin (n = 1,899) were identified from the nationwide diabetes pay-for-performance program (n = 814,465) in Taiwan...
January 2018: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29304178/impact-of-influenza-vaccine-on-childhood-otitis-media-in-taiwan-a-population-based-study
#14
Pei-Wen Wu, Chien-Chia Huang, Wei-Chieh Chao, Chi-Chin Sun, Cheng-Hsun Chiu, Ta-Jen Lee
PURPOSE: Acute otitis media (AOM) is a common infectious disease in children and usually accompanied by a preceding viral respiratory tract infection, especially in the preschool-age population. The study aimed to evaluate impact of influenza vaccine on childhood otitis media. METHODS: This retrospective cohort study included data for 803,592 children (<10 years old) recorded in Taiwan's National Health Insurance Research Database. AOM incidence and tympanostomy tube insertion incidence in each influenza season before and after the introduction of traditional injectable trivalent influenza vaccine (TIV) were compared using the Poisson regression analysis to estimate the incidence rate ratios (IRRs) and 95% confidence intervals (CIs)...
2018: PloS One
https://www.readbyqxmd.com/read/29304089/autoimmune-rheumatic-diseases-increase-dementia-risk-in-middle-aged-patients-a-nationwide-cohort-study
#15
Tzu-Min Lin, Wei-Sheng Chen, Jau-Jiuan Sheu, Yi-Hsuan Chen, Jin-Hua Chen, Chi-Ching Chang
OBJECTIVE: Dementia is a common neurological disease that substantially affects public health. A previous study revealed that dementia occurs when the body's immune system attacks the cells of the brain, indicating that dementia may be similar to autoimmune rheumatic diseases (ARDs). In the current retrospective cohort study, we focused on middle-aged ARD patients (45 years or older) to investigate the association between ARDs in middle-aged people and dementia by using a nationwide population-based database in Taiwan...
2018: PloS One
https://www.readbyqxmd.com/read/29303707/the-influence-of-disease-modifying-anti-rheumatic-drugs-and-corticosteroids-on-the-association-between-rheumatoid-arthritis-and-skin-cancer-a-nationwide-retrospective-case-control-study-in-taiwan
#16
Hui-Wen Tseng, Ling-Ying Lu, Hing-Chung Lam, Kuo-Wang Tsai, Wei-Chun Huang, Yow-Ling Shiue
OBJECTIVES: To investigate the influence of corticosteroids and disease-modifying anti-rheumatic drugs (DMARDs, including conventional synthetic and biologic DMARDs) treatment on the association between rheumatoid arthritis (RA) and non-melanoma skin cancer (NMSC). METHODS: This nationwide retrospective case-control study retrieved data from Taiwan National Health Insurance Research Database during 1995-2013. Cases with newly-diagnosed NMSC (n=19,603) were matched with control without NMSC in a 1:1 ratio according to age, sex, and reference date...
December 15, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29301669/sexually-transmitted-infection-among-adolescents-and-young-adults-with-attention-deficit-hyperactivity-disorder-a-nationwide-longitudinal-study
#17
Mu-Hong Chen, Ju-Wei Hsu, Kai-Lin Huang, Ya-Mei Bai, Nai-Ying Ko, Tung-Ping Su, Cheng-Ta Li, Wei-Chen Lin, Shih-Jen Tsai, Tai-Long Pan, Wen-Han Chang, Tzeng-Ji Chen
OBJECTIVE: Previous studies have suggested that attention-deficit/hyperactivity disorder (ADHD) is related to risky sexual behaviors, which have been regarded as a major risk factor of sexually transmitted infection (STI). However, the association between ADHD and subsequent STIs remains unknown. METHOD: Using the Taiwan National Health Insurance Research Database, 17,898 adolescents and young adults who were diagnosed with ADHD by psychiatrists and 71,592 age- and sex-matched comparisons without ADHD were enrolled from 2001 through 2009 and followed to the end of 2011...
January 2018: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/29301579/linagliptin-and-cardiovascular-outcomes-in-type-2-diabetes-after-acute-coronary-syndrome-or-acute-ischemic-stroke
#18
Yan-Rong Li, Sung-Sheng Tsai, Dong-Yi Chen, Szu-Tah Chen, Jui-Hung Sun, Hung-Yu Chang, Miaw-Jene Liou, Tien-Hsing Chen
BACKGROUND: The cardiovascular safety and efficacy of linagliptin, a dipeptidyl peptidase-4 inhibitor, in patients with type 2 diabetes mellitus (T2DM) after acute coronary syndrome (ACS) or acute ischemic stroke (AIS) are unclear. The aim of our real-world cohort study was to evaluate the cardiovascular outcomes of linagliptin in patients with T2DM after ACS or AIS. METHODS: An open observational noncrossover retrospective cohort study was conducted between June 1, 2012 and December 31, 2013 utilizing Taiwan National Health Insurance Research Database...
January 4, 2018: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29297057/association-of-cardiovascular-risk-with-inhaled-long-acting-bronchodilators-in-patients-with-chronic-obstructive-pulmonary-disease-a-nested-case-control-study
#19
Meng-Ting Wang, Jun-Ting Liou, Chen Wei Lin, Chen-Liang Tsai, Yun-Han Wang, Yu-Juei Hsu, Jyun-Heng Lai
Importance: The associations between cardiovascular disease (CVD) and inhaled long-acting β2-agonists (LABAs) or long-acting antimuscarinic antagonists (LAMAs) in chronic obstructive pulmonary disease (COPD) are greatly debated. Pivotal and relevant randomized clinical trials included prior LABA or LAMA users and excluded patients with baseline CVD; therefore, cardiovascular events arising from first-time LABA or LAMA use, if any, could not be observed. There is an urgent need to examine whether new use of and duration since initiating LABAs and LAMAs could act as important determinants of cardiovascular events...
January 2, 2018: JAMA Internal Medicine
https://www.readbyqxmd.com/read/29296048/long-term-risk-of-dementia-following-acute-kidney-injury-a-population-based-study
#20
Chih-Chin Kao, Che-Hsiung Wu, Chun-Fu Lai, Tao-Min Huang, Hsi-Hsien Chen, Vin-Cent Wu, Likwang Chen, Mai-Szu Wu, Kwan-Dun Wu
Objective: Adverse neurological effects may be common following acute kidney injury (AKI). The purpose of our study was to investigate the long-term risk of dementia following AKI and temporary dialysis during hospitalization. Materials and Methods: The study was based on data from the National Health Insurance Research Database of Taiwan. Patients 18-year-old and older who were withdrawn from temporary dialysis because of AKI and survived for at least 90 days following discharge were included in our acute-dialysis-recovery group...
October 2017: Ci Ji Yi Xue za Zhi, Tzu-chi Medical Journal
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