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Neuropathic bladder

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https://www.readbyqxmd.com/read/28132559/the-female-experience-of-isc-with-a-silicone-catheter
#1
Karen Logan
Intermittent self-catheterisation (ISC) is a safe and effective treatment in the management of neuropathic bladder, voiding dysfunction and urinary incontinence in women. ISC has been shown to improve quality of life when used appropriately. It provides freedom for individuals who require bladder drainage as they can choose where and when to catheterise to empty the bladder. ISC requires minimum equipment, is a more discreet solution than an indwelling catheter and is relatively easy to teach in one patient visit...
January 26, 2017: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/28089079/repeated-subarachnoid-administrations-of-autologous-mesenchymal-stromal-cells-supported-in-autologous-plasma-improve-quality-of-life-in-patients-suffering-incomplete-spinal-cord-injury
#2
Jesús Vaquero, Mercedes Zurita, Miguel A Rico, Celia Bonilla, Concepción Aguayo, Cecilia Fernández, Noemí Tapiador, Marta Sevilla, Carlos Morejón, Jesús Montilla, Francisco Martínez, Esperanza Marín, Salvador Bustamante, David Vázquez, Joaquín Carballido, Alicia Rodríguez, Paula Martínez, Coral García, Mercedes Ovejero, Marta V Fernández
BACKGROUND AIMS: Cell therapy with mesenchymal stromal cells (MSCs) offers new hope for patients suffering from spinal cord injury (SCI). METHODS: Ten patients with established incomplete SCI received four subarachnoid administrations of 30 × 10(6) autologous bone marrow MSCs, supported in autologous plasma, at months 1, 4, 7 and 10 of the study, and were followed until the month 12. Urodynamic, neurophysiological and neuroimaging studies were performed at months 6 and 12, and compared with basal studies...
January 6, 2017: Cytotherapy
https://www.readbyqxmd.com/read/28087925/host-responses-to-urinary-tract-infections-and-emerging-therapeutics-sensation-and-pain-within-the-urinary-tract
#3
Lori A Birder, David J Klumpp
Urinary tract infection (UTI) pathogenesis is understood increasingly at the level of the uropathogens and the cellular and molecular mediators of host inflammatory responses. However, little is known about the mediators of symptoms during UTI and what distinguishes symptomatic events from asymptomatic bacteriuria. Here, we review bladder physiology and sensory pathways in the context of an emerging literature from murine models dissecting the host and pathogen factors mediating pain responses during UTI. The bladder urothelium is considered a mediator of sensory responses and appears to play a role in UTI pain responses...
October 2016: Microbiology Spectrum
https://www.readbyqxmd.com/read/27936385/interrater-reliability-in-pediatric-urodynamic-tracings-a-pilot-study
#4
Anne G Dudley, Daniel P Casella, Chelsea J Lauderdale, Shilin Zhao, Heidi Chen, Stacy T Tanaka, John C Thomas, John C Pope, Mark C Adams, John W Brock, Chevis N Shannon, Douglass B Clayton
PURPOSE: Urodynamic studies are crucial to neuropathic bladder management and they often determine surgical intervention. However, current evidence indicates that interpretations show poor agreement across physicians. We sought to determine the interrater reliability of urodynamic interpretation in our practice. We hypothesized that there would be strong correlation among pediatric urologists of similar training in a single academic practice. MATERIALS AND METHODS: We retrospectively identified patients with neuropathic bladder who underwent urodynamics at our institution between 2014 and 2015...
December 7, 2016: Journal of Urology
https://www.readbyqxmd.com/read/27924350/-use-of-intracutaneous-or-subcutaneous-botulinum-toxin-for-postherpetic-neuralgia
#5
L Halb, B J Amann, H Bornemann-Cimenti
BACKGROUND: Botulinum neurotoxin (BoNT), a toxin of the anaerobic spore-forming bacterium Clostridium botulinum is used as a drug for alleviating muscle spasticity. Other indications include the cosmetic application in facial muscles, hyperhidrosis and neurogenic bladder disorders. It has been approved since 2010 as the first prophylactic treatment for chronic migraine. The analgesic effect of BoNT was observed early on and is currently the subject of intensive research. Painful postherpetic neuralgia is a common complication of an infection with herpes zoster virus...
December 6, 2016: Der Nervenarzt
https://www.readbyqxmd.com/read/27909622/the-effectiveness-of-biofeedback-therapy-in-children-with-monosymptomatic-enuresis-resistant-to-desmopressin-treatment
#6
Eyüp Burak Sancak, Alpaslan Akbaş, Ömer Kurt, Cabir Alan, Ahmet Reşit Ersay
OBJECTIVE: To investigate the effect of biofeedback therapy on children with desmopressin- resistant primary monosymptomatic enuresis (MsE). MATERIAL AND METHODS: The study comprised both retrospective and prospective sections. A total of 262 medical files of patients who were diagnosed as enuresis between November 2012 and January 2015 were retrospectively screened. Patients with neuropathic bladder, daytime voiding problems, anatomical pathology and enuresis-related diseases were excluded from the study...
December 2016: Turkish Journal of Urology
https://www.readbyqxmd.com/read/27869492/risk-factors-for-development-of-primary-bladder-squamous-cell-carcinoma
#7
K V Manley, R Hubbard, D Swallow, W Finch, S J Wood, S M Biers
INTRODUCTION The aim of this study was to investigate the prevalence of risk factors for primary squamous cell carcinoma (SCC) of the bladder. MATERIALS A total of 90 cases of primary SCC of the bladder were identified through multicentre analysis. Patient demographics, stage and grade of cancer at presentation, management and outcomes were recorded. The presence of known risk factors (catheter use, neuropathic bladder, smoking history, recurrent urinary tract infection and bladder stones) was also documented...
February 2017: Annals of the Royal College of Surgeons of England
https://www.readbyqxmd.com/read/27852964/spinal-astrocytic-activation-contributes-to-mechanical-allodynia-in-a-rat-model-of-cyclophosphamide-induced-cystitis
#8
Bolong Liu, Minzhi Su, ShaoJun Tang, Xiangfu Zhou, Hailun Zhan, Fei Yang, Wenbiao Li, Tengcheng Li, Juncong Xie
BACKGROUND: Previous studies have demonstrated that glial cells play an important role in the generation and maintenance of neuropathic pain. Activated glial cells produce numerous mediators such as proinflammatory cytokines that facilitate neuronal activity and synaptic plasticity. Similarly, bladder pain syndrome/interstitial cystitis shares many characteristics of neuropathic pain. However, related report on the involvement of spinal glia in bladder pain syndrome/interstitial cystitis-associated pathological pain and the underlying mechanisms are still lacking...
2016: Molecular Pain
https://www.readbyqxmd.com/read/27820732/a-rare-intramedullary-spinal-cord-metastasis-from-a-retroperitoneal-leiomyosarcoma-presenting-as-a-non-traumatic-spinal-cord-injury
#9
Andrew Lamberth Parker, Terrence Pugh, Mark A Hirsch
Leiomyosarcoma (LMS) is a rare but well-recognized malignant soft tissue sarcoma of smooth muscle origin. Metastases commonly occur in the lungs, liver, kidney, brain, and bone. Cases of metastatic osseous lesions or other extradural space-occupying masses secondary to LMS leading to neurologic compromise are relatively commonplace in the literature. Conversely, cases of intramedullary spinal cord metastasis (ISCM), an unusual entity as a sequela of any cancer, are exceedingly rare as a consequence of LMS. Only 2 cases of an ISCM from LMS are currently documented in the literature, and to the best of our knowledge, no case is described in the rehabilitation literature...
November 4, 2016: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/27716521/human-esc-derived-interneurons-improve-major-consequences-of-spinal-cord-injury
#10
Armin Blesch
Beyond impaired motor and sensory function, neuropathic pain and loss of bladder control caused by spinal cord injuries (SCIs) can severely affect quality of life. In this issue of Cell Stem Cell, Fandel et al. (2016) show that transplanted human ESC-derived cells biased to produce inhibitory interneurons significantly improve pain and bladder function in rodent SCI models.
October 6, 2016: Cell Stem Cell
https://www.readbyqxmd.com/read/27687533/robotic-assisted-laparoscopic-bladder-augmentation-in-the-pediatric-patient
#11
A C Wiestma, C R Estrada, P S Cho, M V Hollis, R N Yu
INTRODUCTION: Bladder augmentation is a common surgical intervention for neuropathic bladder dysfunction, and has conventionally been an open procedure. We present a robotic ileocystoplasty to demonstrate the feasibility of an entirely intracorporeal approach in a pediatric patient. METHODS: The patient was a 6 year old (18.5 kg) boy with a neurogenic bladder secondary to lumbar myelomeningocele. Urodynamics revealed a small capacity and poorly compliant bladder and he was incontinent between frequent catheterizations...
October 2016: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/27687531/long-term-outcomes-of-the-kropp-and-salle-urethral-lengthening-bladder-neck-reconstruction-procedures
#12
K M Szymanski, R C Rink, B Whittam, J D Ring, R Misseri, M Kaefer, M P Cain
INTRODUCTION: The Kropp and Salle procedures have shown good short-term outcomes for managing neuropathic urinary incontinence. However, few studies have assessed their long-term results. OBJECTIVE: This study aimed to evaluate the long-term outcomes of Kropp and Salle procedures, including: dryness, secondary interventions for incontinence or complications, upper urinary tract changes, and use of urethral catheterizations. STUDY DESIGN: Consecutive patients undergoing Kropp and Salle procedures at the present institution (1983-2012) were retrospectively reviewed...
December 2016: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/27666009/transplanted-human-stem-cell-derived-interneuron-precursors-mitigate-mouse-bladder-dysfunction-and-central-neuropathic-pain-after-spinal-cord-injury
#13
Thomas M Fandel, Alpa Trivedi, Cory R Nicholas, Haoqian Zhang, Jiadong Chen, Aida F Martinez, Linda J Noble-Haeusslein, Arnold R Kriegstein
Neuropathic pain and bladder dysfunction represent significant quality-of-life issues for many spinal cord injury patients. Loss of GABAergic tone in the injured spinal cord may contribute to the emergence of these symptoms. Previous studies have shown that transplantation of rodent inhibitory interneuron precursors from the medial ganglionic eminence (MGE) enhances GABAergic signaling in the brain and spinal cord. Here we look at whether transplanted MGE-like cells derived from human embryonic stem cells (hESC-MGEs) can mitigate the pathological effects of spinal cord injury...
October 6, 2016: Cell Stem Cell
https://www.readbyqxmd.com/read/27647215/secondary-health-conditions-activity-limitations-and-life-satisfaction-in-older-adults-with-long-term-spinal-cord-injury
#14
Sophie Jörgensen, Susanne Iwarsson, Jan Lexell
BACKGROUND: Many individuals with a spinal cord injury (SCI) have lived several decades with their injury, leading to a need for a deeper understanding of factors associated with healthy aging in people with long-term SCI. OBJECTIVES: To (1) describe secondary health conditions, activity limitations, and life satisfaction in older adults with long-term SCI, and to (2) investigate how sociodemographics, injury characteristics, and secondary health conditions are associated with their activity limitations and life satisfaction...
September 17, 2016: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/27636866/effects-of-early-surgical-decompression-on-functional-and-histological-outcomes-after-severe-experimental-thoracic-spinal-cord-injury
#15
Devesh Jalan, Neginder Saini, Mohammad Zaidi, Alexandra Pallottie, Stella Elkabes, Robert F Heary
OBJECTIVE In acute traumatic brain injury, decompressive craniectomy is a common treatment that involves the removal of bone from the cranium to relieve intracranial pressure. The present study investigated whether neurological function following a severe spinal cord injury improves after utilizing either a durotomy to decompress the intradural space and/or a duraplasty to maintain proper flow of cerebrospinal fluid. METHODS Sixty-four adult female rats (n = 64) were randomly assigned to receive either a 3- or 5-level decompressive laminectomy (Groups A and B), laminectomy + durotomy (Groups C and D), or laminectomy + duraplasty with graft (Group E and F) at 24 hours following a severe thoracic contusion injury (200 kilodynes)...
January 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/27601933/large-subcapsular-hematoma-following-ureteroscopic-laser-lithotripsy-of-renal-calculi-in-a-spina-bifida-patient-lessons-we-learn
#16
Subramanian Vaidyanathan, Azi Samsudin, Gurpreet Singh, Peter L Hughes, Bakul M Soni, Fahed Selmi
INTRODUCTION: Paraplegic patients are at greater risk of developing complications following ureteroscopic lithotripsy because of urine infection associated with neuropathic bladder, difficulties in access due to altered anatomy of urinary bladder and urethra, spinal curvature, spasticity, and contractures. We report the occurrence of large subcapsular hematoma following ureteroscopy and discuss lessons we learn from this case. CASE REPORT: A 48-year-old male patient with spina bifida underwent ureteroscopy with laser lithotripsy and ureteric stenting for left ureteric stone and staghorn calculus with hydronephrosis; laser lithotripsy was repeated after 3 months; both procedures were performed by a senior urologist and did not result in any complications...
2016: International Medical Case Reports Journal
https://www.readbyqxmd.com/read/27569433/bladder-training-video-versus-standard-urotherapy-for-bladder-and-bowel-dysfunction-a-noninferiority-randomized-controlled-trial
#17
Luis H Braga, Mandy Rickard, Forough Farrokhyar, Kizanee Jegatheeswaran, Natasha Brownrigg, Christine Li, Rahul Bansal, Jorge DeMaria, Armando J Lorenzo
PURPOSE: We evaluated whether an animated bladder training video was as effective as standard individual urotherapy in improving bladder/bowel symptoms. MATERIALS AND METHODS: Patients 5 to 10 years old who scored greater than 11 on the bladder/bowel Vancouver questionnaire were included in a noninferiority randomized, controlled trial. Children with vesicoureteral reflux, neuropathic bladder, learning disabilities, recent urotherapy or primary nocturnal enuresis were excluded from analysis...
August 26, 2016: Journal of Urology
https://www.readbyqxmd.com/read/27542858/cystatin-c-calculated-glomerular-filtration-rate-a-marker-of-early-renal-dysfunction-in-patients-with-neuropathic-bladder
#18
Pankaj P Dangle, Omar Ayyash, Audry Kang, Carlton Bates, Janelle Fox, Heidi Stephany, Glenn Cannon
OBJECTIVE: To asses if cystatin c-calculated glomerular filtration rate (GFR) can reveal chronic kidney disease (CKD) not detected by creatinine-based calculations in a larger prospective cohort of children with myelomeningocele (MMC). Wheelchair-bound MMC patients frequently have low muscle mass, and assessing renal deterioration based on creatinine-based GFR is imprecise. MMC patients are also at risk for end-stage renal disease. METHODS: Prospectively enrolled patients with MMC underwent annual serum creatinine and cystatin c testing...
August 16, 2016: Urology
https://www.readbyqxmd.com/read/27517862/transitional-urology-for-male-adolescents-what-adult-urologists-should-know
#19
REVIEW
Kristina D Suson
In recent years, there has been increasing interest in transitional urology, or how to best prepare patients with major congenital urologic diseases, such as bladder exstrophy and neuropathic bladder, to manage their own health care with adult urologists. However, common pediatric urologic conditions may be encountered by the adult urologist with more regularity. This review focuses on three relatively common conditions which may be identified in childhood, the consequences from which a patient may seek help from an adult urologist: cryptorchidism, varicocele, and Klinefelter syndrome...
October 2016: Current Urology Reports
https://www.readbyqxmd.com/read/27410467/evaluation-of-tissue-engineering-products-for-the-management-of-neuropathic-diabetic-foot-ulcers-an-interim-analysis
#20
R G Frykberg, S M Cazzell, J Arroyo-Rivera, A Tallis, A M Reyzelman, F Saba, L Warren, B C Stouch, T W Gilbert
OBJECTIVE: The objective of this prospective, multicentre clinical study is to assess the application of MatriStem MicroMatrix (MSMM) and MatriStem Wound Matrix (MSWM) (porcine urinary bladder derived extracellular matrix) compared with Dermagraft (DG) (human fibroblast-derived dermal substitute) for the management of non-healing diabetic foot ulcers (DFUs). METHOD: A randomised, multicentre study was conducted at thirteen centers throughout the US. It was designed to evaluate the incidence of ulcer closure, rate of ulcer healing, wound characteristics, patient quality of life, cost-effectiveness, and recurrence...
July 2016: Journal of Wound Care
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