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Mitomycin C

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https://www.readbyqxmd.com/read/28101045/express-mini-shunt-as-a-treatment-alternative-for-medically-uncontrolled-steroid-induced-glaucoma-in-a-pediatric-patient
#1
Bonnie Nga Kwan Choy, Mandy Oi Man Wong, Jonathan Cheuk Hung Chan, Connie Hong Yee Lai, Jimmy Shiu Ming Lai
This case report illustrates the use of ExPRESS mini-shunt in a pediatric glaucoma patient. We describe the management of steroid-induced glaucoma with ExPRESS mini-shunt in a 9-year-old boy with allergic keratoconjunctivitis. The intraocular pressure of both of his eyes was uncontrolled with medical and laser treatment. Both eyes were treated with ExPRESS mini-shunt and mitomycin-C. Transient overfiltration with postoperative hypotony occurred in both eyes and resolved after 2 weeks. One year postoperatively, intraocular pressure was maintained below 21 mm Hg without medication in 1 eye...
September 2016: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/28100482/mitomycin-c-augmented-trabeculectomy-subtenon-injection-versus-soaked-sponges-a-randomised-clinical-trial
#2
Mohammad Pakravan, Hamed Esfandiari, Shahin Yazdani, Azadeh Douzandeh, Nassim Amouhashemi, Mehdi Yaseri, Parto Pakravan
BACKGROUND/AIMS: To compare the efficacy and safety of subtenon injection of mitomycin C (MMC) with that of conventional application of MMC-soaked sponges in trabeculectomy. METHODS: In this multicentre randomised clinical trial, 80 consecutive open-angle glaucoma cases were randomised into two groups; group 1 received a subtenon injection of 0.1 mL of 0.01% MMC, while group 2 received 0.02% MMC-soaked sponges. Primary outcome measure was intraocular pressure (IOP), and secondary outcome measures were endothelial cell count (ECC) changes and bleb morphology according to the Indiana Bleb Appearance Grading Scale...
January 18, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28091920/comparative-study-of-antitumor-efficiency-of-intraperitoneal-and-intravenous-cytostatics-in-experimental-rats-with-disseminated-ovarian-cancer
#3
V G Bespalov, E A Vyshinskaya, I N Vasil'eva, A L Semenov, M A Maidin, N V Barakova, A N Stukov
Antitumor efficiencies of cytostatics dioxadet, cisplatin, mitomycin C, melphalan, and paclitaxel after a single intraperitoneal or intravenous injection in doses of 1.5, 4, 1.5, 2, and 5 mg/kg, respectively, were studied on the model of transplanted ovarian tumor in 124 rats. The antitumor effects were evaluated by the increase in median survival. Dioxadet, cisplatin, and melphalan injected intraperitoneally significantly prolonged the lifespan median - by 79, 88, and 114%, respectively, and were in fact ineffective, when injected intravenously...
January 2017: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28089307/corrigendum-to-beneficial-effects-of-5-fluorouracil-and-heparin-based-portal-infusion-chemotherapy-combined-with-mitomycin-c-and-cisplatin-after-curative-resection-of-pancreatic-cancer-pancreatology-10-2010-250-258
#4
Koichi Aiura, Shin Takahashi, Junichi Matsui, Masakazu Ueda, Yuko Kitagawa
No abstract text is available yet for this article.
January 11, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/28079688/retrospective-comparative-study-of-topical-interferon-%C3%AE-2b-versus-mitomycin-c-for-primary-ocular-surface-squamous-neoplasia
#5
Rakhi Kusumesh, Anita Ambastha, Shishir Kumar, Bibhuti Prasan Sinha, Nazia Imam
PURPOSE: To compare the efficacy and safety of topical interferon alpha 2b (IFNα2b) and mitomycin C (MMC) for ocular surface squamous neoplasia. METHODS: In this retrospective study, medical records of 51 eyes of 50 patients with a diagnosis of primary ocular surface squamous neoplasia were included. All cases were treated with either topical IFNα2b (1 million IU/mL) or MMC (0.4 mg/mL) 4 times a day. The primary outcome measure was frequency of clinical resolution of tumors along with failure and recurrence rates after treatment...
January 11, 2017: Cornea
https://www.readbyqxmd.com/read/28079687/periocular-amyloidosis-manifesting-as-pseudopemphigoid-treated-with-mitomycin-c
#6
Kaveh Vahdani, Vladimir T Thaller, Giorgio Albanese, Andrew F Dean
PURPOSE: To describe an unusual cicatrizing manifestation of periocular amyloid and the utility of adjuvant antimetabolite therapy. METHODS: This is a case report of a 49-year old woman with progressive bilateral upper lid ptosis, who was found to have bilateral inferior forniceal masses with thickening of the conjunctiva. Conjunctival and eyelid biopsies showed evidence of amyloid deposition. Systemic evaluation did not reveal any evidence of systemic amyloidosis...
January 11, 2017: Cornea
https://www.readbyqxmd.com/read/28077981/dna-polymerase-kappa-protects-human-cells-against-mmc-induced-genotoxicity-through-error-free-translesion-dna-synthesis
#7
Yuki Kanemaru, Tetsuya Suzuki, Akira Sassa, Kyomu Matsumoto, Noritaka Adachi, Masamitsu Honma, Satoshi Numazawa, Takehiko Nohmi
BACKGROUND: Interactions between genes and environment are critical factors for causing cancer in humans. The genotoxicity of environmental chemicals can be enhanced via the modulation of susceptible genes in host human cells. DNA polymerase kappa (Pol κ) is a specialized DNA polymerase that plays an important role in DNA damage tolerance through translesion DNA synthesis. To better understand the protective roles of Pol κ, we previously engineered two human cell lines either deficient in expression of Pol κ (KO) or expressing catalytically dead Pol κ (CD) in Nalm-6-MSH+ cells and examined cytotoxic sensitivity against various genotoxins...
2017: Genes and Environment: the Official Journal of the Japanese Environmental Mutagen Society
https://www.readbyqxmd.com/read/28072461/adverse-and-beneficial-effects-in-chinese-hamster-lung-fibroblast-cells-following-radiofrequency-exposure
#8
Anna Sannino, Olga Zeni, Stefania Romeo, Rita Massa, Maria Rosaria Scarfi
In this study, the effect of radiofrequency (RF) exposure to 1950 MHz, Universal Mobile Telecommunication System signal, was investigated in Chinese hamster lung fibroblast cell line (V79). Genotoxic and cytotoxic effects of 20-h exposure at specific absorption rate (SAR) values from 0.15 W/kg to 1.25 W/kg were measured by means of cytokinesis-block micronucleus (MN) assay. Exposure was carried out blinded under strictly controlled conditions of dosimetry and temperature. The effect of RF exposure alone at four SAR values was tested, that is, 0...
January 10, 2017: Bioelectromagnetics
https://www.readbyqxmd.com/read/28070874/infection-of-defective-human-t-lymphotropic-virus-type-1
#9
Yuuki Hashikura, Kazumi Umeki, Kunihiko Umekita, Hajime Nomura, Akiteru Yamada, Ikuo Yamamoto, Hiroo Hasegawa, Katsunori Yanagihara, Akihiko Okayama
In a previous study, we reported that an identical defective provirus had integrated into multiple sites of the genome of a representative human T-lymphotropic virus type 1 (HTLV-1) cell line, MT-2. A possible explanation for this may be the repeated infection of this defective provirus to a cell. Therefore, we attempted to determine whether a defective provirus could transmit during the co-culture of HTLV-1 uninfected human T-cell line, Jurkat, with MT-2 cells treated with mitomycin C. As a result, we established not only a cell line with the integration of one complete provirus, but also a cell line with the integration of one defective provirus...
January 9, 2017: Human Cell
https://www.readbyqxmd.com/read/28069374/assessment-of-genotoxic-and-antigenotoxic-activities-of-artepillin-c-in-somatic-cells-of-drosophila-melanogaster
#10
Carmem Regine Faleiro Rodrigues, Luciana Ciarelli Plentz, Mariana do Amaral Flores, Rafael Rodrigues Dihl, Mauricio Lehmann
The significant contents of artepillin C (AC) in green propolis have prompted research on the biological activities of the compound. The present study evaluated the activity of this phenolic compound on DNA, assessing its genotoxic and antigenotoxic potentials in the somatic mutation and recombination test in Drosophila melanogaster. The standard (ST) and high-bioactivation (HB) crosses were used in the assessment of genotoxic potential, since they express cytochrome P450 metabolization enzymes differently...
January 6, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28068448/photorefractive-keratectomy-with-mitomycin-c-in-meesmann-s-epithelial-corneal-dystrophy
#11
Ramon Coral Ghanem, André Luís Piccinini, Vinícius Coral Ghanem
PURPOSE: To describe a case of Meesmann's epithelial corneal dystrophy that underwent photorefractive keratectomy (PRK) with mitomycin C. METHODS: Case report. RESULTS: A 36-year-old woman was evaluated for refractive surgery. She had a history of recurrent epithelial erosions and moderate visual loss over the past 10 years. Biomicroscopy revealed bilateral micro-cystic epithelial lesions and a diagnosis of Meesmann's epithelial corneal dystrophy was proposed...
January 1, 2017: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/28068238/hematologic-nadirs-during-chemoradiation-for-anal-cancer-temporal-characterization-and-dosimetric-predictors
#12
Andrew Y Lee, Daniel W Golden, Jose G Bazan, Malgorzata Kopec, Charles A Pelizzari, Sonya Aggarwal, Daniel T Chang, Stanley L Liauw
PURPOSE: Pelvic bone marrow (BM) constraints may offer a means to reduce the toxicity commonly associated with chemoradiation for anal cancer. We conducted a bi-institutional analysis of dose-volume metrics in a time-sensitive fashion to devise practical metrics to minimize hematologic toxicity. METHODS AND MATERIALS: Fifty-six anal cancer patients from 2 institutions received definitive radiation therapy (median primary dose of 54 Gy) using intensity modulated radiation therapy (IMRT, n=49) or 3-dimensional (3D) conformal therapy (n=7) with concurrent 5-fluorouracil (5-FU) and mitomycin C...
February 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28065395/serial-retrograde-instillations-of-sustained-release-formulation-of-mitomycin-c-to-the-upper-urinary-tract-of-the-yorkshire-swine-using-a-thermosensitive-polymer-safety-and-feasibility
#13
Nicholas M Donin, Dalit Strauss-Ayali, Yael Agmon-Gerstein, Nadav Malchi, Andrew T Lenis, Stuart Holden, Allan J Pantuck, Arie S Belldegrun, Karim Chamie
BACKGROUND: MitoGel is a novel drug formulation intended for the treatment of upper tract urothelial cancer with proven feasibility and safety in an animal model. OBJECTIVE: To evaluate the feasibility, safety, toxicokinetics, and histologic changes associated with serial retrograde MitoGel instillations to the upper urinary tract in a swine model. DESIGN, SETTING, AND PARTICIPANTS: Overall, 27 Yorkshire swine underwent 6 once-weekly unilateral retrograde instillations of MitoGel...
January 3, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28063893/a-plasmid-encoded-dsba-homologue-is-a-growth-phase-regulated-thioredoxin
#14
Amada Díaz-Magaña, Martha P Chávez-Moctezuma, Jesús Campos-García, Martha I Ramírez-Díaz, Carlos Cervantes
The Pseudomonas aeruginosa plasmid pUM505 contains in a pathogenicity island the dsbA2 gene, which encodes a product with similarity to DsbA protein disulfide isomerases, enzymes that catalyze formation and isomerization of disulfide bonds in protein cysteine residues. Using transcriptional fusions, it was found that dsbA2 gene promoter is activated during the stationary phase, suggesting that DsbA2 protein may be required for adaptive changes that occur during this stage of bacterial growth. Transfer of the pUM505 dsbA2 gene to a cadmium-sensitive P...
January 4, 2017: Plasmid
https://www.readbyqxmd.com/read/28062463/ymc-2011-a-temperate-phage-of-streptococcus-salivarius-57-i
#15
Wen-Chun Chou, Szu-Chuan Huang, Cheng-Hsun Chiu, Yi-Ywan M Chen
: Streptococcus salivarius is an abundant isolate of the oral cavity. The genome of S. salivarius 57.I consists of a 2-Mb chromosome and a 40,758-bp circular molecule, designated YMC-2011. Annotation of YMC-2011 revealed 55 open reading frames, most of them associated with phage production, although plaque formation is not observed in S. salivarius 57.I after lytic induction using mitomycin C. Results from Southern hybridization and quantitative real-time PCR confirmed that YMC-2011 exists extrachromosomally with an estimated copy number of 3 to 4...
January 6, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28060939/large-preferred-region-for-packaging-of-bacterial-dna-by-phic725a-a-novel-pseudomonas-aeruginosa-f116-like-bacteriophage
#16
Christine Pourcel, Cédric Midoux, Yolande Hauck, Gilles Vergnaud, Libera Latino
Bacteriophage vB_PaeP_PAO1_phiC725A (short name phiC725A) was isolated following mitomycin C induction of C7-25, a clinical Pseudomonas aeruginosa strain carrying phiC725A as a prophage. The phiC725A genome sequence shows similarity to F116, a P. aeruginosa podovirus capable of generalized transduction. Likewise, phiC725A is a podovirus with long tail fibers. PhiC725A was able to lysogenize two additional P. aeruginosa strains in which it was maintained both as a prophage and in an episomal state. Investigation by deep sequencing showed that bacterial DNA carried inside phage particles originated predominantly from a 700-800kb region, immediately flanking the attL prophage insertion site, whether the phages were induced from a lysogen or recovered after infection...
2017: PloS One
https://www.readbyqxmd.com/read/28058152/the-effect-of-adjuvant-intracameral-triamcinolone-acetonide-on-the-surgical-results-of-trabeculectomy-with-mitomycin-c
#17
Neşe Alagöz, Cengiz Alagöz, Yusuf Yıldırım, Ceren Yeşilkaya, Çiğdem Altan, Ercüment Bozkurt, Banu Şatana, Berna Başarır, Muhittin Taşkapılı
OBJECTIVES: To evaluate the effect of adjuvant intracameral triamcinolone acetonide (TA) on the surgical results of trabeculectomy with mitomycin C. MATERIALS AND METHODS: All consecutive trabeculectomy cases performed in the glaucoma clinic between July 2012 and December 2013 were retrospectively reviewed from the patient charts. Only those with follow-up of 12 months or longer were included. Patients with intraoperative intracameral TA (study group, n=19) were compared to those without TA (control group, n=21) in terms of surgical success, intraocular pressure (IOP) change, medication use and complications...
August 2016: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/28049602/are-there-hiv-specific-differences-for-anal-cancer-patients-treated-with-standard-chemoradiotherapy-in-the-era-of-combined-antiretroviral-therapy
#18
D Martin, P Balermpas, E Fokas, C Rödel, M Yildirim
AIMS: Contradicting evidence exists regarding the safety and clinical outcome of standard treatment in HIV-positive patients with anal cancer. We report on our large, single-centre experience in HIV-positive versus HIV-negative patients treated in the era of combined antiretroviral therapy (CART). MATERIALS AND METHODS: Between 1997 and 2015, 142 patients (42 HIV-positive versus 100 HIV-negative) with anal cancer were treated with standard chemoradiotherapy. Patients received a median dose of 50...
December 31, 2016: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/28048054/su-f-j-05-the-effect-of-air-pockets-in-the-urinary-bladder-during-bladder-hyperthermia-treatment
#19
G Schooneveldt, H P Kok, A Bakker, E D Geijsen, T M de Reijke, J Crezee
PURPOSE: Hyperthermia combined with Mitomycin C is used for the treatment of non-muscle invasive bladder cancer (NMIBC), using a phased array system of microwave antennas for bladder heating. Often some air is present in the bladder, which effectively blocks the microwave radiation, potentially preventing proper treatment of that part of the bladder. Air can be a relevant fraction of the bladder content and large air pockets are expected to have a noticeable influence on achieved temperatures...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28045540/characterization-of-pegylated-liposomal-mitomycin-c-lipid-based-prodrug-promitil%C3%A2-by-high-sensitivity-differential-scanning-calorimetry-and-cryogenic-transmission-electron-microscopy
#20
Xiaohui Wei, Yogita Patil, Patricia Ohana, Yasmine Amitay, Hilary Shmeeda, Alberto Gabizon, Yechezkel Barenholz
The effect of a lipidated prodrug of mitomycin C (MLP) on the membrane of a pegylated liposome formulation (PL-MLP), also known as Promitil®, was characterized through high-sensitivity differential scanning calorimetry (DSC), and cryo-TEM. The thermodynamic analysis demonstrated that MLP led to the formation of heterogeneous domains in the membrane plane of PL-MLP. MLP concentrated in prodrug-rich domains, arranged in high-ordered crystal-like structures, as suggested by the sharp and high enthalpy endotherm in the 1st heating scanning...
January 3, 2017: Molecular Pharmaceutics
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