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Mitomycin C

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https://www.readbyqxmd.com/read/29156644/akt1-stimulates-homologous-recombination-repair-of-dna-double-strand-breaks-in-a-rad51-dependent-manner
#1
Katharina Mueck, Simone Rebholz, Mozhgan Dehghan Harati, H Peter Rodemann, Mahmoud Toulany
Akt1 is known to promote non-homologous end-joining (NHEJ)-mediated DNA double-strand break (DSB) repair by stimulation of DNA-PKcs. In the present study, we investigated the effect of Akt1 on homologous recombination (HR)-dependent repair of radiation-induced DSBs in non-small cell lung cancer (NSCLC) cells A549 and H460. Akt1-knockdown (Akt1-KD) significantly reduced Rad51 protein level, Rad51 foci formation and its colocalization with γH2AX foci after irradiation. Moreover, Akt1-KD decreased clonogenicity after treatment with Mitomycin C and HR repair, as tested by an HR-reporter assay...
November 20, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29156531/heated-naringin-mitigate-the-genotoxicity-effect-of-mitomycin-c-in-balb-c-mice-through-enhancing-the-antioxidant-status
#2
Mouna Maatouk, Nadia Mustapha, Imen Mokdad-Bzeouich, Hind Chaaban, Irina Ioannou, Kamel Ghedira, Mohamed Ghoul, Leila Chekir-Ghedira
A major problem with cancer chemotherapy is its severe toxic effects on non-target tissues. Assessment of natural products for their protective effect against anticancer drugs induced toxicity is gaining importance in cancer biology. The aim of the present study was to evaluate the effect of native and thermal treated naringin on the protective effect against mitomycin C (MMC) induced genotoxicity. The genotoxicity in liver kidney and brain cells isolated from Balb/C mice were evaluated by performing the comet assay...
November 15, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29154021/diagnosis-of-fanconi-anaemia-by-ionising-radiation-or-mitomycin-c-induced-micronuclei
#3
Flavia Zita Francies, Rosalind Wainwright, Janet Poole, Kim De Leeneer, Ilse Coene, Greet Wieme, Hélène A Poirel, Bénédicte Brichard, Stephanie Vermeulen, Anne Vral, Jacobus Slabbert, Kathleen Claes, Ans Baeyens
Fanconi Anaemia (FA) is an autosomal recessive disorder characterised by defects in DNA repair, associated with chromosomal instability and cellular hypersensitivity to DNA cross-linking agents such as mitomycin C (MMC). The FA repair pathway involves complex DNA repair mechanisms crucial for genomic stability. Deficiencies in DNA repair genes give rise to chromosomal radiosensitivity. FA patients have shown increased clinical radiosensitivity by exhibiting adverse normal tissue side-effects. The study aimed to investigate chromosomal radiosensitivity of homozygous and heterozygous carriers of FA mutations using three micronucleus (MN) assays...
November 8, 2017: DNA Repair
https://www.readbyqxmd.com/read/29151685/intraoperative-injection-vs-sponge-applied-mitomycin-c-during-trabeculectomy-one-year-study
#4
Albert S Khouri, Grace Huang, Linda Y Huang
Aim: To determine the safety and efficacy of intraoperative injection of mitomycin C (MMC) against conventional sponge-applied MMC during trabeculectomy. Materials and methods: This study was a retrospective, comparative case series. Thirty eyes with primary open-angle glaucoma underwent consecutive trabeculectomies with MMC injection (injection group), and thirty eyes with sponge-applied MMC were as controls (sponge group). Data were collected preoperatively and postoperatively at 1 day, 1 week, 1 month, 3 months, 6 months, and 1 year after surgery...
September 2017: Journal of Current Glaucoma Practice
https://www.readbyqxmd.com/read/29151651/rna-binding-domain-is-necessary-for-pprm-function-in-response-to-the-extreme-environmental-stress-in-deinococcus-radiodurans
#5
Wei Li, Yun Ma, Jie Yang, Fangzhu Xiao, Wuzhou Wang, Shuya He
Deinococcus radiodurans was considered as one of the most radiation-resistant organisms on Earth because of its strong resistance to the damaging factors of both DNA and protein, including ionizing radiation, ultraviolet radiation, oxidants, and desiccation. PprM, as a bacterial cold shock protein homolog, was involved in the radiation resistance and oxidative stress response of D. radiodurans, but its potential mechanisms are poorly expounded. In this study, we found that PprM was highly conserved with the RNA-binding domain in Deinococcus genus through performing phylogenic analysis...
December 2017: Indian Journal of Microbiology
https://www.readbyqxmd.com/read/29147757/prospective-evaluation-of-co2-laser-assisted-sclerectomy-surgery-class-with-mitomycin-c
#6
Carlo Alberto Cutolo, Alessandro Bagnis, Riccardo Scotto, Chiara Bonzano, Carlo Enrico Traverso
PURPOSE: Our purpose was to evaluate the clinical safety and efficacy of CO2 laser-assisted sclerectomy surgery (CLASS) with Mitomycin C (MMC) in open angle glaucoma (OAG). METHODS: This was a prospective, uncontrolled, interventional case series. All subjects underwent CLASS procedure by a single surgeon. After the dissection of a partial thickness scleral flap, topical MMC 0.2 mg/ml was applied to the sclera and the conjunctiva for 3 min. The CO2 laser with a beam-manipulating system was used to ablate the scleral tissue and expose the Schlemm's canal area...
November 17, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29142609/role-of-5-aza-cdr-in-mitomycin-c-chemosensitivity-of-t24-bladder-cancer-cells
#7
Hui-Hui Zhang, Bo Huang, You-Han Cao, Qing Li, Han-Feng Xu
Chemotherapeutic insensitivity is one of key obstacles to effectively treating muscle invasive bladder cancer. 5-Aza-2'-deoxycytidine (5-Aza-CdR) has been identified as a tumor suppressive agent in various types of cancer. The aim of the present study was to identify the effects of 5-Aza-CdR on the mitomycin-C (MMC) chemosensitivity of T24 bladder cancer cells and investigate the underlying mechanisms. T24 cells were treated with a combination of MMC and 5-Aza-CdR at various concentrations. The rates of proliferation and apoptosis were assessed by an MTT assay and flow cytometry, respectively...
November 2017: Oncology Letters
https://www.readbyqxmd.com/read/29133641/simultaneous-use-of-amniotic-membrane-and-mitomycin-c-in-trabeculectomy-for-primary-glaucoma
#8
Usha Yadava, Kirti Jaisingh, Sonal Dangda, Prolima Thacker, Kirti Singh, Yashpal Goel
PURPOSE: This study aimed to propose the role of amniotic membrane transplantation (AMT) as an additional modulator in primary Mitomycin C (MMC)-augmented trabeculectomy. METHODS: This was a randomized prospective interventional study. Forty eyes of 39 adult patients with uncontrolled primary glaucoma were randomly divided into two equal groups. Control group underwent trabeculectomy augmented with MMC while the study group underwent additional AMT. Patients were followed up for 12 months and outcomes measured were intraocular pressure (IOP), need for additional intervention, and bleb morphology...
November 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29126568/treatment-options-and-predictive-factors-for-recurrence-and-cancer-specific-mortality-in-bladder-cancer-after-renal-transplantation-a-multi-institutional-analysis
#9
O Rodriguez Faba, J Palou, H Vila Reyes, L Guirado, A Palazzetti, P Gontero, F Vigués, J Garcia-Olaverri, J M Fernández Gómez, J Olsburg, C Terrone, A Figueiredo, J Burgos, E Lledó, A Breda
OBJECTIVES: Bladder cancer (BC) in the transplanted population can represent a challenge owing to the immunosuppressed state of patients and the higher rate of comorbidities. The objective was to analyze the treatment of BC after renal transplant (RT), focusing on the mode of presentation, diagnosis, treatment options and predictive factors for recurrence. MATERIAL AND METHODS: We conducted an observational prospective study with a retrospective analysis of 88 patients with BC after RT at 10 European centers...
November 7, 2017: Actas Urologicas Españolas
https://www.readbyqxmd.com/read/29121674/the-helicase-ding-responds-to-stress-due-to-dna-double-strand-breaks
#10
Stephan A Frye, Getachew Tesfaye Beyene, Amine Namouchi, Marta Gómez-Muñoz, Håvard Homberset, Shewit Kalayou, Tahira Riaz, Tone Tønjum, Seetha V Balasingham
Neisseria meningitidis (Nm) is a Gram-negative nasopharyngeal commensal that can cause septicaemia and meningitis. The neisserial DNA damage-inducible protein DinG is a helicase related to the mammalian helicases XPD and FANCJ. These helicases belong to superfamily 2, are ATP dependent and exert 5' → 3' directionality. To better understand the role of DinG in neisserial genome maintenance, the Nm DinG (DinGNm) enzymatic activities were assessed in vitro and phenotypical characterization of a dinG null mutant (NmΔdinG) was performed...
2017: PloS One
https://www.readbyqxmd.com/read/29121140/complications-of-cosmetic-eye-whitening
#11
Ann Q Tran, Catherine Hoppener, Nandini Venkateswaran, Daniel S Choi, Wendy W Lee
Introduced in 2008 and subsequently popularized in South Korea, cosmetic eye whitening has been offered as a treatment of chronic conjunctival hyperemia. Patients undergo conjunctivectomy with topical mitomycin C (MMC) 0.02% application to achieve a whitened appearance from bleaching of avascular sclera. Much speculation has arisen from this procedure given the limited available evidence on its efficacy and safety. A literature search was performed to review common complications of cosmetic eye whitening, including chronic conjunctival epithelial defects, scleral thinning, avascular zones in the sclera, dry eye syndrome, and diplopia requiring strabismus surgery...
September 2017: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/29118494/comparison-between-ologen-implant-and-different-concentrations-of-mitomycin-c-as-an-adjuvant-to-trabeculectomy-surgery
#12
Zeiad H Eldaly, Ali A Maasoud, Mohamed S Saad, Abdelsalam A Mohamed
CONTEXT: Trabeculectomy is the most common surgical procedure for treatment of glaucoma. To improve success rates, adjuvants were utilized as Mitomycin C (MMC) and Ologen implant. AIMS: This study aims to establish efficacy and safety of Ologen implant versus MMC in trabeculectomy. SETTING AND DESIGN: A prospective, comparative clinical study was conducted at the Department of Ophthalmology, Assiut University, between December 2014 and April 2016...
September 2017: Oman Journal of Ophthalmology
https://www.readbyqxmd.com/read/29117004/outcomes-of-trabeculectomy-and-phacotrabeculectomy-with-collagen-matrix-implant-ologen-and-low-dose-mitomycin-c-two-year-follow-up
#13
Miguel A Castejón, Miguel A Teus, Gema Bolivar, Javier Paz, Beatriz Castaño
PURPOSE: To analyse the results achieved in lowering intraocular pressure (IOP) after trabeculectomy or combined surgery (phacotrabeculectomy) with low-dose mitomycin C (MMC) using the Ologen Collagen Matrix implant (Ologen CM). METHODS: This retrospective study included 58 eyes from 47 consecutive patients with glaucoma who underwent filtering surgery alone or combined with cataract surgery. The study group included 29 eyes that underwent trabeculectomy (14 eyes) or phacotrabeculectomy (15 eyes) with low-dose MMC (0...
November 7, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/29114593/quantitative-fdg-pet-ct-predicts-local-recurrence-and-survival-for-squamous-cell-carcinoma-of-the-anus
#14
Michael L Cardenas, Christopher R Spencer, Stephanie Markovina, Todd A DeWees, Thomas R Mazur, Ashley A Weiner, Parag J Parikh, Jeffrey R Olsen
Purpose: (18)F-fluorodeoxyglucose (FDG) positron emission tomography-(PET)/computed tomography (CT) imaging is used for staging and treatment planning of patients with anal cancer. Quantitative pre- and posttreatment metrics that are predictive of recurrence are unknown. We evaluated the association between pre- and posttreatment FDG-PET/CT parameters and outcomes for patients with squamous cell carcinoma of the anus (SCCA). Methods and materials: The records of 110 patients treated between 2003 and 2013 with definitive radiation therapy for SCCA were reviewed under an institutional review board-approved protocol...
July 2017: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/29114374/prevention-of-chemotherapy-induced-nephrotoxicity-in-children-with-cancer
#15
REVIEW
Fatemeh Ghane Sharbaf, Hamid Farhangi, Farahnak Assadi
Children with cancer treated with cytotoxic drugs are frequently at risk of developing renal dysfunction. The cytotoxic drugs that are widely used for cancer treatment in children are cisplatin (CPL), ifosfamide (IFO), carboplatin, and methotrexate (MTX). Mechanisms of anticancer drug-induced renal disorders are different and include acute kidney injury (AKI), tubulointerstitial disease, vascular damage, hemolytic uremic syndrome (HUS), and intrarenal obstruction. CPL nephrotoxicity is dose-related and is often demonstrated with hypomagnesemia, hypokalemia, and impaired renal function with rising serum creatinine and blood urea nitrogen levels...
2017: International Journal of Preventive Medicine
https://www.readbyqxmd.com/read/29113247/induction-of-oxidative-stress-by-anticancer-drugs-in-the-presence-and-absence-of-cells
#16
Chikako Yokoyama, Yuto Sueyoshi, Mika Ema, Yumi Mori, Kazuto Takaishi, Hisashi Hisatomi
Reactive oxygen species (ROS) are generated in the cell through multiple mechanisms. Intracellular ROS are rapidly detoxified by various enzymatic and non-enzymatic mechanisms; however, disruption of the oxidant-antioxidant balance causes oxidative stress and elicits cell damage. The oxidative stress induced by chemotherapy is known to cause side effects in patients with cancer. However, few studies have examined whether anticancer drugs induce oxidative stress in cancer cells. Furthermore, the precise mechanism by which anticancer drugs induce the generation of ROS remains unclear...
November 2017: Oncology Letters
https://www.readbyqxmd.com/read/29111617/ocular-and-periocular-hemangiosarcoma-in-six-horses
#17
REVIEW
Nicole M Scherrer, Mary Lassaline, Julie Engiles
OBJECTIVE: To determine the characteristics of and prognosis for ocular and periocular hemangiosarcoma in horses. ANIMAL STUDIED: Six horses treated for ocular or periocular hemangiosarcoma. PROCEDURE: A retrospective review of medical records from 2007 to 2015 was performed to identify horses with a histologic diagnosis of ocular or periocular hemangiosarcoma. Signalment (age, sex, breed), duration of clinical signs, prior treatment, tumor size and location, medical and surgical treatment including postoperative chemotherapy, follow-up time, and outcome were obtained from medical records...
November 7, 2017: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/29096629/serratia-marcescens-endophthalmitis-after-pterygium-surgery-a-case-report
#18
Myeong Yeon Yi, Jin Kwon Chung, Kyung Seek Choi
BACKGROUND: To report a case of Serratia marcescens endophthalmitis after pterygium surgery using the bare sclera technique with mitomycin C (MMC). CASE PRESENTATION: A 69-year-old male patient underwent pterygium excision surgery using the bare sclera technique and 0.02% MMC. The patient presented with decreased visual acuity and pain from the day after the operation. Trans pars plana vitrectomy was performed and intravitreal antibiotics were administered. Cultures from the aqueous humor and intraocular lens were all positive for S...
November 2, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/29089784/cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy-for-appendiceal-goblet-cell-carcinomas-with-peritoneal-carcinomatosis-results-from-a-single-specialized-center
#19
Hsin-Hsien Yu, Yutaka Yonemura, Mao-Chih Hsieh, Akiyoshi Mizumoto, Satoshi Wakama, Chang-Yun Lu
BACKGROUND: Goblet cell carcinomas (GCCs) of the appendix are rare and aggressive malignancies with early peritoneal dissemination. The aim of the present article is to describe our experience in the management of GCCs with peritoneal carcinomatosis (PC) through cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) and to determine the impact of multiple clinical characteristics on the prognosis. METHODS: From a prospectively maintained database of patients receiving CRS and HIPEC for peritoneal surface malignancy, the data of 15 patients with GCC and PC were collected...
2017: Cancer Management and Research
https://www.readbyqxmd.com/read/29077233/death-effects-of-reveromycin-a-in-normal-and-disease-associated-cells-of-the-joint
#20
Haley Svrcina, Austin Greer, Seth Baker, Morgan Smith, Patricia Martinez, Nathan Granger, Natassja Thomas, Jaylin Miller, Ellen Steinke, Kelsey Davitt, Emily Sloane, Lauren Nugent, Ryan Sabo, Calli Williams, Mark A Lipton, Daniel Jones
Earlier work in our laboratory demonstrated that naturally occurring reveromycin A (Rev A) causes apoptosis in osteoclasts without accompanying necrosis. Rev A death effects in both normal and diseased joint cells were investigated in this study. 10 □M Rev A did not cause apoptosis nor necrosis in monolayer chondrocytes, even at pH 6.8, a pH mimicking that of an inflamed joint. In contrast, at the acidic pH Rev A did induce significant apoptosis (four-fold increase at 48 hours of treatment, p<0.005) in normal synoviocytes without accompanying necrosis...
October 27, 2017: Journal of Cellular Biochemistry
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