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Mitomycin C

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https://www.readbyqxmd.com/read/27922138/mitomycin-c-treated-human-induced-pluripotent-stem-cells-as-a-safe-delivery-system-of-gold-nanorods-for-targeted-photothermal-therapy-of-gastric-cancer
#1
Meng Yang, Yanlei Liu, Wenxiu Hou, Xiao Zhi, Chunlei Zhang, Xinquan Jiang, Fei Pan, Yuming Yang, Jian Ni, Daxiang Cui
Human-induced pluripotent stem cells (iPS) possess an intrinsic tumor tropism ability. However, iPS cells are impeded in clinical applications of tumor therapy due to the formation of teratomas and their survival in normal organs such as the liver, lungs, spleen and kidneys. Mitomycin C (MMC) can overcome this limitation by suppressing iPS proliferation. Herein, we fabricated a safe delivery system of iPS cells treated with MMC loading with gold nanorods (AuNRs) for the targeted photothermal treatment of gastric cancer...
December 6, 2016: Nanoscale
https://www.readbyqxmd.com/read/27915139/impairment-of-fetal-hematopoietic-stem-cell-function-in-the-absence-of-fancd2
#2
Sakiko Suzuki, Ronny R Racine, Nathan A Manalo, Sharon B Cantor, Glen D Raffel
Fanconi Anemia (FA), results from mutations in genes necessary for DNA damage repair and often leads to progressive bone marrow failure. Although the exhaustion of the bone marrow leads to cytopenias in FA patients as they age, evidence from human FA and mouse model fetal livers suggests hematopoietic defects originate in utero which may lead to deficient seeding of the bone marrow. To address this possibility, we examined the consequences of loss of Fancd2, a central component of the FA pathway. Examination of E14...
November 30, 2016: Experimental Hematology
https://www.readbyqxmd.com/read/27905335/incidence-of-short-term-complications-and-associated-factors-after-primary-trabeculectomy-in-chiang-mai-university-hospital
#3
Thidarat Leeungurasatien, Preeyanuch Khunsongkiet, Kassara Pathanapitoon, Damrong Wiwatwongwana
BACKGROUND: To determine the incidence of early postoperative complications and associated factors after primary trabeculectomy in Thai glaucoma patients. DESIGN: This was a retrospective observational study performed in Chiang Mai University Hospital. PARTICIPANTS: One hundred and eighteen glaucoma patients participated in the study. METHODS: All glaucoma patients underwent primary trabeculectomy with mitomycin C (MMC) using fornix-based conjunctival flap technique between December 2011 and May 2013...
October 2016: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/27899782/-trans-arterial-chemoembolization-therapy-for-giant-cholangiocellular-carcinoma-a-single-case-report
#4
Keita Yamashiro, Astushi Hori, Takeo Yuki, Ryosuke Ohira, Shinichi Hori
Here, we report a case of cholangiocellular carcinoma that was successfully treated with chemotherapy using a selective intra-arterial infusion technique. A 65-year-old man presented to our hospital to obtain a second opinion regarding his disease. The patient was diagnosed with cholangiocellular carcinoma. The giant tumor was located in the porta hepatis. Some small nodules that were considered to be metastatic lesions were also observed in the surroundingarea. The tumor was judged by the primary physician to be too large for surgical treatment...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/27896441/pterygium-surgery-using-the-principle-of-contact-inhibition-results-of-13-years-experience
#5
Tsutomu Hara, Takako Hashimoto, Takeshi Hara
PURPOSE: To report a technique to prevent pterygium recurrence using the principle of contact inhibition. METHODS: Two hundred and fifteen patients (232 eyes; average age, 64.1 years) with primary pterygia who underwent pterygium surgery at the Hara Eye Hospital between 1999 and 2012. We retrospectively evaluated the patients who underwent the following procedure to prevent pterygium recurrence. The surface conjunctiva on the pterygium body was not removed. After removing the pterygium body, by placing a narrow pedicle autoconjunctival flap along the corneal limbus and tying it tightly to the front area of the residual conjunctiva, there is no room for the active residual tissue to proliferate, thus preventing a recurrence by contact inhibition...
November 28, 2016: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/27893886/integrin-%C3%AE-5%C3%AE-1-inhibition-by-clt-28643-reduces-postoperative-wound-healing-in-a-mouse-model-of-glaucoma-filtration-surgery
#6
Tine Van Bergen, Grit Zahn, Patrizia Caldirola, Mario Fsadni, Ninus Caram-Lelham, Evelien Vandewalle, Lieve Moons, Ingeborg Stalmans
Purpose: To evaluate the therapeutic potential of the small molecule integrin α5β1 inhibitor, CLT-28643, to improve the filtering surgery outcome in a mouse model. Different dose regimens and administration routes of the inhibitor were compared with mitomycin C (MMC), the gold standard in clin ical practice. Methods: The efficacy of CLT-28643 on surgical outcome was studied in a mouse model for filtering surgery (n = 40 eyes from 20 mice per group). Single and repeated subconjunctival (SCJ) injections (1 or 2 μg) and topical eye drops (10 μg) of the integrin inhibitor were compared with 2-minute administration of MMC 0...
November 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27889038/treatment-of-the-primary-tumor-in-anal-canal-cancers
#7
REVIEW
Rob Glynne-Jones, Sheela Rao
Radical concurrent chemoradiotherapy with 5-fluorouracil and mitomycin C (MMC) remains the standard of care for squamous cell carcinoma of the anus. Phase III trials over 2 decades have used combined radiation doses of 50 to 60 Gy with concurrent fluoropyrimidines, MMC, or cisplatin in various doses and schedules. Modern radiotherapy techniques allow the production of highly conformal plans, decreasing radiation doses to the organs at risk and ensuring a shorter overall treatment time without the need for treatment breaks...
January 2017: Surgical Oncology Clinics of North America
https://www.readbyqxmd.com/read/27884539/intravesical-chemotherapy-use-after-radical-nephroureterectomy-a-national-survey-of-urologic-oncologists
#8
Diane D Lu, Stephen A Boorjian, Jay D Raman
: To determine the use of prophylactic intravesical chemotherapy (pIVC) following radical nephroureterectomy (RNU) and barriers to utilization in a survey study of urologic oncologists. METHODS: A survey instrument was constructed, which queried respondents on professional experience, practice environment, pIVC use, and reasons for not recommending pIVC when applicable. The survey was electronically distributed to members of the Society of Urologic Oncology over an 8-week period...
November 21, 2016: Urologic Oncology
https://www.readbyqxmd.com/read/27879653/ellagic-acid-inhibits-bladder-cancer-invasiveness-and-in-vivo-tumor-growth
#9
Claudia Ceci, Lucio Tentori, Maria Grazia Atzori, Pedro M Lacal, Elena Bonanno, Manuel Scimeca, Rosella Cicconi, Maurizio Mattei, Maria Gabriella de Martino, Giuseppe Vespasiani, Roberto Miano, Grazia Graziani
Ellagic acid (EA) is a polyphenolic compound that can be found as a naturally occurring hydrolysis product of ellagitannins in pomegranates, berries, grapes, green tea and nuts. Previous studies have reported the antitumor properties of EA mainly using in vitro models. No data are available about EA influence on bladder cancer cell invasion of the extracellular matrix triggered by vascular endothelial growth factor-A (VEGF-A), an angiogenic factor associated with disease progression and recurrence, and tumor growth in vivo...
November 22, 2016: Nutrients
https://www.readbyqxmd.com/read/27875486/evaluation-of-corneal-deformation-parameters-provided-by-the-corvis-st-tonometer-after-trabeculectomy
#10
Yuan Zong, Na Wu, Zhixuan Fu, Xiangmei Kong
PURPOSE: The aims of this study were to evaluate how the corneal deformation parameters provided by the Corvis ST tonometer (CST) were influenced by pressure-lowering ocular surgery, and to determine the correlations of intraocular pressure (IOP) and axial length (AL) with CST corneal deformation parameters. METHODS: This prospective 1-month study enrolled 22 subjects (22 eyes) who underwent trabeculectomy combined with mitomycin C. The corneal deformation parameters were measured using the CST...
November 21, 2016: Journal of Glaucoma
https://www.readbyqxmd.com/read/27869555/the-influence-of-the-ctip-polymorphism-q418p-on-homologous-recombination-and-predisposition-to-radiation-induced-tumorigenesis-mainly-raml-in-mice
#11
Agata Patel, Jennifer Anderson, Daniela Kraft, Rosemary Finnon, Paul Finnon, Cheryl L Scudamore, Grainne Manning, Robert Bulman, Natalie Brown, Simon Bouffler, Peter O'Neill, Christophe Badie
Exposure to ionizing radiation increases the incidence of acute myeloid leukemia (AML), which has been diagnosed in Japanese atomic bombing survivors, as well as patients treated with radiotherapy. The genetic basis for susceptibility to radiation-induced AML is not well characterized. We previously identified a candidate murine gene for susceptibility to radiation-induced AML (rAML): C-terminal binding protein (CTBP)-interacting protein (CTIP)/retinoblastoma binding protein 8 (RBBP8). This gene is essential for embryonic development, double-strand break (DSB) resection in homologous recombination (HR) and tumor suppression...
November 21, 2016: Radiation Research
https://www.readbyqxmd.com/read/27865791/efficacy-of-2-representative-topical-agents-to-prevent-keloid-recurrence-after-surgical-excision
#12
REVIEW
Jin Yong Shin, Seok-Kweon Yun, Si-Gyun Roh, Nae-Ho Lee, Kyung-Moo Yang
PURPOSE: Keloids are difficult to remove successfully and there is no universally accepted treatment. After surgical excision of the keloid, there are various management methods for prevention of keloid recurrence, such as intralesional injection, radiation, and topical agents. A few studies have compared topical agents with other treatments. The aim of this study was to investigate effective topical agents for the prevention of recurrent keloid after surgical excision. MATERIALS AND METHODS: Eligible articles were sought using core databases, including Medline, Embase, and Cochrane databases, up to April 2016...
October 25, 2016: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/27860168/use-of-a-350-mm-2-baerveldt-glaucoma-drainage-device-to-maintain-vision-and-control-intraocular-pressure-in-dogs-with-glaucoma-a-retrospective-study-2013-2016
#13
Kathleen L Graham, David Donaldson, Francis A Billson, F Mark Billson
OBJECTIVE: To evaluate the 350-mm(2) Baerveldt glaucoma drainage device (GDD) in dogs with refractory glaucoma when modifications to address postoperative hypotony (extraluminal ligature; intraluminal stent) and the fibroproliferative response (intraoperative Mitomycin-C; postoperative oral colchicine and prednisolone) are implemented as reported in human ophthalmology. DESIGN: Retrospective case series. ANIMALS: Twenty-eight client-owned dogs (32 eyes) including seven dogs (nine eyes) with primary glaucoma and 21 dogs (23 eyes) with secondary glaucoma...
November 16, 2016: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/27854142/effects-of-mitomycin-c-in-early-conjunctival-inflammation-after-pterygium-surgery
#14
Claudia da Costa Paula, Gemma Julio, Pamela Campos, Pere Pujol, Mouafk Asaad
PURPOSE: The purpose of this study was to compare inflammatory events and graft characteristics 1 month and 6 months after conjunctival limbal autograft (CLAU) with and without intraoperative mitomycin C (MMC). METHODS: This study included 69 eyes of 69 patient's eyes with pterygium. Clinical data concerning patient demography, preoperative examination including pterygium morphology, recurrence clinical assessment, and complications after CLAU with (MMC+) and without (MMC-) intraoperative MMC were all registered at 1 month and 6 months after surgery...
November 17, 2016: Current Eye Research
https://www.readbyqxmd.com/read/27853012/outcomes-of-endoscopic-dacryocystorhinostomy-experience-of-a-fellowship-trainee-at-a-tertiary-care-center
#15
Saurabh Kamal, Mohammad Javed Ali, Akshay Gopinathan Nair
AIM: The study aims to report a single trainee's experience of learning and performing endoscopic endonasal dacryocystorhinostomy (En-DCR). SETTINGS AND DESIGN: This study was a retrospective, interventional case series. SUBJECTS AND METHODS: Fifty-four eyes of fifty patients presenting at a tertiary eye care center over 1 year were included in the study. All cases underwent endoscopic DCR with mitomycin-C and silicone intubation. The parameters studied included demographics, clinical features, intraoperative details, and postoperative ostium evaluation...
September 2016: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/27843228/study-of-efficacy-and-timing-of-laser-suture-lysis-in-reducing-intraocular-pressure-after-trabeculectomy-with-mitomycin-c
#16
Swati Ramakrishna, Sirish Nelivigi, Asha Maganahalli Sadananda, Sri Ganesh
CONTEXT: Laser suture lysis is used to enhance filtration after trabeculectomy. AIMS: The aim of this is to evaluate the change in intraocular pressure (IOP) after laser suture lysis after trabeculectomy with mitomycin-C and to correlate the efficacy of suture lysis in relation to the time of lysis. SETTINGS AND DESIGN: Prospective interventional study of seventy eyes of seventy patients. SUBJECTS AND METHODS: Trabeculectomy with mitomycin-C was performed for 352 patients with glaucoma...
September 2016: Oman Journal of Ophthalmology
https://www.readbyqxmd.com/read/27835929/endoscopic-treatment-of-benign-esophageal-strictures-a-literature-review
#17
Laurent Poincloux, Olivier Rouquette, Armand Abergel
Benign esophageal strictures arise from various etiologies and are frequently encountered. Although endoscopic dilation is still the first-line therapy, recurrent strictures do occur in approximately 10% of the cases and remains a challenge to gastroenterologists. Areas covered: A literature search was performed using PubMed and Google Scholar databases for original and review articles on endoscopic treatment of benign esophageal strictures. This review outlines the main available treatment options and its controversies in the management of refractory benign esophageal strictures...
November 11, 2016: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27834104/upregulating-dab2ip-expression-via-egr-1-inhibition-a-new-approach-for-overcoming-fractionated-irradiation-induced-cross-tolerance-to-ionizing-radiation-and-mitomycin-c-in-tumor-cells
#18
Rulve Chang, Hui He, Guangmin Mao, Zhaolu Kong
PURPOSE: In this study, we evaluated the effect of fractionated irradiation (FI) on tumor cells sensitivity to ionizing radiation (IR) and antineoplastic drugs, and examined the potential of early growth response-1 (EGR-1) inhibition to sensitize tumor cells to IR. MATERIALS AND METHODS: PC3 and HepG2 cells were subjected to γ-rays at 2 Gy for ten times. Survived cells were named PC3/R and HepG2/R, respectively. Cells sensitivity to irradiation and chemotherapeutic drugs, including cisplatin (PT), doxorubicin (DOX), mitomycin C (MMC) and 5-fluorouracil (5-FU) were identified by colony formation assay and MMT method, respectively...
November 11, 2016: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/27833080/mitomycin-c-treatment-induces-resistance-and-enhanced-migration-via-phosphorylated-akt-in-aggressive-lung-cancer-cells
#19
Cheng-Ying Shen, Li-Han Chen, Yu-Fen Lin, Liang-Chuan Lai, Eric Y Chuang, Mong-Hsun Tsai
Since 1984, mitomycin C (MMC) has been applied in the treatment of non-small-cell lung cancer (NSCLC). MMC-based chemotherapeutic regimens are still under consideration owing to the efficacy and low cost as compared with other second-line regimens in patients with advanced NSCLC. Hence, it is important to investigate whether MMC induces potential negative effects in NSCLC. Here, we found that the malignant lung cancer cells, CL1-2 and CL1-5, were more resistant to MMC than were the parental CL1-0 cells and pre-malignant CL1-1 cells...
November 9, 2016: Oncotarget
https://www.readbyqxmd.com/read/27830980/mucous-membrane-grafting-augmented-with-topical-mitomycin-c-application-in-contracted-socket-repair-surgeries
#20
Sameh S Mandour, Hesham M Elmazar, Hatem M Marey, Ahmed K Abdel Rahman, Rokia A Sakr
PURPOSE: To evaluate the use of intraoperative topical application of mitomycin C (MMC) for managing cases of recurrent socket contraction. METHODS: A prospective comparative randomized study was carried out on 40 patients suffering from contracted sockets. They were randomly enrolled into 2 groups. Group A included 20 patients who had a surgery to treat contracted socket without augmentation with MMC. Group B patients had an MMC-augmented repair for the contracted socket...
December 2016: Journal of Ocular Pharmacology and Therapeutics
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