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Mitomycin C

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https://www.readbyqxmd.com/read/29332339/p21-does-but-p53-does-not-predict-pathological-response-to-preoperative-chemoradiotherapy-in-locally-advanced-rectal-cancer
#1
Suzana Stojanovic-Rundic, Radmila Jankovic, Marjan Micev, Vladimir Nikolic, Ivan Popov, Dusica Gavrilovic, Vesna Plesinac-Karapandzic, Aleksandra Djuric-Stefanovic, Zoran Krivokapic, Sinisa Radulovic
PURPOSE: Preoperative chemoradiotherapy (CRT) is the standard treatment option in locally advanced rectal cancer. The tumor response is assessed through tumor and nodal downstaging and the tumor regression grade. Currently, there is no method to predict a tumor response to CRT. We aimed to evaluate whether p21 and p53 expressions could be a reliable predictors of pathological response to CRT. METHODS: Fifty patients with locally advanced rectal cancer were treated with preoperative radiotherapy combined with mitomycin C and capecitabine...
November 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29330444/lidocaine-enhances-the-effects-of-chemotherapeutic-drugs-against-bladder-cancer
#2
Xihua Yang, Lili Zhao, Meiping Li, Lei Yan, Shengwan Zhang, Zhenguo Mi, Liansheng Ren, Jun Xu
This study aimed to investigate whether lidocaine, alone or in combination with other chemotherapeutic agents, inhibits the growth of human bladder cancer cells in vitro and orthotopically transplanted bladder tumors in vivo. The effects of lidocaine (1.25, 2.5 or 5 mg/mL), mitomycin C (MMC, 0.66 mg/mL), pirarubicin (0.75 mg/mL) and Su Fu'ning lotion (SFN, 0.0625 mg/mL) on the proliferation of human bladder cancer (BIU-87) cells were studied using the MTT assay. A Balb/c nude mouse model of bladder cancer was developed by orthotopic transplantation of BIU-87 cells, and the effects of intravesical instillation of lidocaine and MMC on bladder wet weight (a measure of tumor size) and survival (over 60 days) were studied...
January 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29319922/the-effect-of-timing-of-an-immediate-instillation-with-mitomycin-c-after-transurethral-resection-in-941-non-muscle-invasive-bladder-cancer-patients
#3
Judith Bosschieter, R Jeroen A van Moorselaar, André N Vis, Tessa van Ginkel, Birgit I Lissenberg-Witte, Goedele M A Beckers, Jakko A Nieuwenhuijzen
OBJECTIVES: To investigate whether timing of an immediate instillation (on the day of transurethral resection or one day later) has impact on time to recurrence of non-muscle-invasive bladder cancer. PATIENTS AND METHODS: All patients with non-muscle-invasive bladder cancer who were enrolled in a prospective trial between 1998 and 2003 and treated with an early mitomycin C instillation (on the day of transurethral resection or one day later), were selected. Statistical analysis was performed with Kaplan-Meier curves and multivariable Cox regression...
January 10, 2018: BJU International
https://www.readbyqxmd.com/read/29317300/mesenchymal-stem-cells-therapy-protects-fetuses-from-resorption-and-induces-th2-type-cytokines-profile-in-abortion-prone-mouse-model
#4
Amir Salek Farrokhi, Amir-Hassan Zarnani, Seyed Mohammad Moazzeni
The imbalance of Th1/Th2 cytokines is well known in recurrent spontaneous abortion (RSA) mouse model. Mesenchymal stem cells (MSCs) possess potent immunoregulatory properties that could modulate the Th1 cytokine responses in benefit of Th2 types. In this study, we aimed to analyze the local and systemic balance of Th1/Th2 cytokines following MSCs therapy. Syngeneic adipose derived MSCs were administered to abortion prone mice during the implantation window. The abortion rate was determined and IL-4, IL-6, IL-12, IL-2, IFN-γ and GM-CSF gene expression was evaluated by Real-Time-PCR in decidual and placental tissues of pregnant mice at day 13...
January 6, 2018: Transplant Immunology
https://www.readbyqxmd.com/read/29315438/femtosecond-laser-assisted-lasik-with-and-without-the-adjuvant-use-of-mitomycin-c-to-correct-hyperopia
#5
Montserrat Garcia-Gonzalez, MariLuz Iglesias-Iglesias, Pilar Drake Rodriguez-Casanova, Juan Gros-Otero, Miguel A Teus
PURPOSE: To compare the visual and refractive results of femtosecond laser-assisted LASIK (FS-LASIK) with and without the adjuvant use of mitomycin C (MMC) to correct hyperopia. METHODS: A total of 152 consecutive hyperopic eyes were included in this retrospective, observational cohort study, comparing 76 eyes treated with FS-LASIK + MMC with 76 age- and refraction-matched eyes treated with FS-LASIK without MMC. Visual and refractive results were evaluated 1 day, 1 week, and 1, 3, 6, and 15 months postoperatively...
January 1, 2018: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/29303888/systemic-absorption-of-mitomycin-c-when-used-in-pterygium-surgery
#6
Michael Yulish, Ahmed Khatib, Joseph Pikkel
PURPOSE: To determine whether scleral topical application of mitomycin-C (MMC) results in measurable plasma levels of systemic absorption. METHODS: The study comprised 27 patients who were treated with MMC 0.2 mg/mL (0.02%) for 60 seconds during pterygium surgery. Blood samples were taken 30 minutes after surgery and evaluated by the human plasma liquid chromatography tandem-mass spectrometry method to determine the presence of MMC. RESULTS: The amount of MMC in 27 samples tested was determined as below 0...
January 4, 2018: Cornea
https://www.readbyqxmd.com/read/29303877/trypan-blue-for-the-assessment-of-filtering-bleb-function-during-cataract-surgery
#7
Edward Stephen Yung, Marlene R Moster, Carina Sanvicente, John Pluta, Kamran Rahmatnejad, Arjun S Patel, Alice Williams, Ben Abramowitz, L Jay Katz, Michael Pro
PURPOSE: Phacoemulsification has been cited as a possible cause of bleb failure in eyes with prior trabeculectomy. No method has been developed to directly evaluate the risk of bleb failure after phacoemulsification. We investigate the use of trypan blue during cataract surgery in the setting of a pre-existing trabeculectomy to evaluate the functional status of the bleb and predict post-operative bleb function. PATIENTS AND METHODS: 14 patients contributing one eye each with a history of prior trabeculectomy with mitomycin C undergoing phacoemulsification with intraocular lens implantation were enrolled in this prospective, nonrandomized clinical trial...
January 4, 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29303876/optical-coherence-tomography-angiography-description-of-ocular-decompression-retinopathy-after-deep-sclerectomy-in-traumatic-glaucoma
#8
Lauriane Salinas, Ankita Chaudhary, Kaweh Mansouri
PURPOSE: To present a case of ocular decompression retinopathy (ODR) occurring after uncomplicated deep sclerectomy with Mitomycin C using optical coherence tomography angiography (OCTA). PATIENT AND METHOD: Single case report. RESULTS: A 55-year-old man with traumatic glaucoma in the right eye complained of blurred vision. Visual acuity was 20/25 and intraocular pressure (IOP) was 50▒mm Hg. Deep sclerectomy with Mitomycin C was performed...
January 4, 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29297460/topical-mitomycin-c-application-for-the-control-of-recurrent-tracheal-stenosis-even-after-tracheal-surgery
#9
Jung Soo Kim, Jun Hyeok Lim, Sang-Hoon Jeon, Jeong-Seok Choi, Young Sam Kim, Hae-Seong Nam
No abstract text is available yet for this article.
December 1, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/29286884/antigenotoxicity-properties-of-copaifera-multijuga-oleoresin-and-its-chemical-marker-the-diterpene-copalic-acid
#10
Jacqueline Morais Alves, Luís Fernando Leandro, Juliana Marques Senedese, Pâmela Tinti de Castro, Daiane Eleutério Pereira, Flávia Aparecida Resende, Débora Leite Campos, Jonas Joaquim Mangabeira da Silva, Eliana Aparecida Varanda, Jairo Kenupp Bastos, Sérgio Ricardo Ambrósio, Denise Crispim Tavares
In view of the biological activities and growing therapeutic interest in oleoresin obtained from Copaifera multijuga, this study aimed to determine the genotoxic and antigenotoxic potential of this oleoresin (CMO) and its chemical marker, diterpene (-)-copalic acid (CA). The micronucleus (MN) assay in V79 cell cultures and the Ames test were used for in vitro analyses, as well as MN and comet assays in Swiss mice for in vivo analyses. The in vitro genotoxicity/mutagenicity results showed that either CMO (30, 60, or 120 µg/ml-MN assay; 0...
December 29, 2017: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/29283127/rescue-of-failing-or-failed-trabeculectomy-blebs-with-slit-lamp-needling-and-adjunctive-mitomycin-c-in-indian-eyes
#11
Vanita Pathak-Ray, Nikhil Choudhari
PURPOSE: The aim of this study is to investigate the efficacy and safety of needling-revision augmented with a high dose of mitomycin C (MMC) in failing or failed blebs after trabeculectomy in Indian eyes. METHODS: Prospective, noncomparative, interventional study. All patients (>18 years) who had raised intraocular pressure (IOP) following trabeculectomy (>6 weeks and <2 years), who had a flat bleb, bleb encapsulation, and/or required antiglaucoma medication (AGM) for IOP control were eligible for inclusion...
January 2018: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29283126/comparison-of-surgical-outcomes-between-canaloplasty-and-trabeculectomy-with-mitomycin-c-at-2-year-follow-up-a-longitudinal-cohort-study
#12
Winston J Garris, Crystal Le, David Zurakowski, Ramesh S Ayyala
PURPOSE: To compare operative outcomes of patients after canaloplasty and trabeculectomy with mitomycin C (MMC) through 2-year follow-up. METHODS: We included 31 eyes of 31 patients with primary open-angle glaucoma (POAG) who underwent canaloplasty and 37 eyes of 37 patients with POAG who underwent trabeculectomy with MMC with 24 months of postoperative follow-up. All surgeries were performed by a single surgeon between January 2005 and May 2011. Failure was defined as intraocular pressure (IOP> 18 or <4 mmHg at 2 years), second operative procedure, or loss of light perception...
January 2018: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29281929/protective-effect-of-aspirin-against-mitomycin-c-induced-carcinogenicity-assessed-by-the-test-for-detection-of-epithelial-tumor-clones-warts-in-drosophila-melanogaster
#13
Victor Constante Oliveira, Sarah Alves Rodrigues Constante, Lorena Polloni, Priscila Capelari Orsolin, Rosiane Gomes Silva-Oliveira, Nayane Moreira Machado, Robson José de Oliveira-Júnior, Júlio César Nepomuceno
The present study assessed the protective effect of aspirin against carcinogenicity induced by mitomycin C (MMC) by the test for detection of warts/epithelial tumor clones in Drosophila melanogaster. Larvae were treated with different concentrations of aspirin alone (10, 20 or 40 mg/mL) or aspirin in association with MMC. MMC and ultrapure water were employed as the positive and negative control, respectively. Antioxidant activity was determined using the DPPH method. For performing cytotoxicity assay on HeLa cells, the aspirin concentrations used ranged from 200 mmol/L to 3,125 mmol/L...
December 27, 2017: Drug and Chemical Toxicology
https://www.readbyqxmd.com/read/29277751/regimens-of-intraperitoneal-chemotherapy-for-peritoneal-carcinomatosis-from-colorectal-cancer
#14
REVIEW
Koji Murono, Kazushige Kawai, Keisuke Hata, Shigenobu Emoto, Manabu Kaneko, Kazuhito Sasaki, Takeshi Nishikawa, Kensuke Otani, Toshiaki Tanaka, Hiroaki Nozawa
Although systemic chemotherapy has been improved, peritoneal carcinomatosis remains a factor of poor prognosis in patients with colorectal cancer. In order to achieve a higher drug concentration in the peritoneal cavity, intraperitoneal chemotherapy has been performed. However, the optimal regimen for intraperitoneal chemotherapy has not been determined. In this review of intraperitoneal chemotherapy for colorectal cancer, we summarize regimens of hyperthermic intraperitoneal chemotherapy (HIPEC) and other intraperitoneal chemotherapy modalities, such as early postoperative intraperitoneal chemotherapy (EPIC) and sequential postoperative intraperitoneal chemotherapy (SPIC)...
January 2018: Anticancer Research
https://www.readbyqxmd.com/read/29274020/short-term-change-in-higher-order-aberrations-after-mitomycin-c-augmented-trabeculectomy
#15
Seong Ho Jo, Je Hyun Seo
PURPOSE: To investigate the changes in ocular higher-order aberrations (HOA) after trabeculectomy using mitomycin-C (MMC). METHODS: We retrospectively reviewed data for 63 eyes from 63 glaucoma patients who had undergone MMC augmented trabeculectomy. We measured intraocular pressure (IOP), refractive errors, anterior chamber depth (ACD), and HOA before surgery and 1, 2, and 4 weeks postoperatively. The patients were divided into two groups on the basis of preoperative lens status: phakic and pseudophakic group...
December 22, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/29260042/conjunctival-squamous-papilloma-refractory-to-interferon-%C3%AE-2b-in-a-patient-on-systemic-immunosuppression-tacrolimus
#16
Preethi S Ganapathy, Thomas Plesec, Arun D Singh
Purpose: To describe a case of diffuse conjunctival papilloma in an immunocompromised individual on tacrolimus that was refractory to treatment with interferon α-2b, but responded to topical mitomycin-c. Observations: A 79-year-old Caucasian female with a history of a liver transplant twenty years ago, who was immunosuppressed with tacrolimus (2 mg daily) presented with a diffuse conjunctival and corneal squamous papilloma. Following treatment with four weekly subconjunctival interferon-α2b injections (3 million units/0...
June 2017: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29259917/a-novel-suturing-technique-for-filtering-glaucoma-surgery-the-accordion-suture
#17
REVIEW
Mehmet Baykara, Basak Can Ermerak, Huri Sabur, Selim Genc
AIM: To present a novel scleral flap suturing technique for filtering glaucoma surgery in order to control high postoperative intraocular pressure (IOP). METHODS: Description of 'the accordion suture' technique for mitomycin C augmented trabeculectomy. In cases of postoperative high IOP, pulling the loop of the suture helps to lift up the scleral flap by an even pressure on both edges. By means of this technique, the scleral flap opens up in an "accordion" manner, thus preventing flap obstruction and providing adequate aqueous flow...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/29258720/safety-of-intraperitoneal-mitomycin-c-versus-intraperitoneal-oxaliplatin-in-patients-with-peritoneal-carcinomatosis-of-colorectal-cancer-undergoing-cytoreductive-surgery-and-hipec
#18
W J van Eden, N F M Kok, K Woensdregt, A D R Huitema, H Boot, A G J Aalbers
BACKGROUND: Colorectal peritoneal carcinomatosis (PC) is commonly treated with cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC). There is an ongoing international debate about which intraperitoneal chemotherapeutic agent is preferred, Mitomycin C (MMC) or oxaliplatin. We questioned whether the type of chemotherapeutic agent influenced postoperative complication rates or short-term survival. METHODS: In this retrospective cohort study patients with colorectal PC who underwent CRS-HIPEC between January 2010 and December 2016 were included...
November 15, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29258490/cytotoxic-antioxidative-genotoxic-and-antigenotoxic-effects-of-horchata-beverage-of-south-ecuador
#19
Natalia Bailon-Moscoso, Fani Tinitana, Ruth Martínez-Espinosa, Andrea Jaramillo-Velez, Alejandra Palacio-Arpi, Jessica Aguilar-Hernandez, Juan Carlos Romero-Benavides
BACKGROUND: "Horchata" is an herbal mixture infusion consumed in Southern Ecuador; 66% of its plants are anti-inflammatory medicinal plant, and 51% are analgesics. Anti-inflammatory substances can prevent carcinogenesis mediated by cytotoxic effects and can prevent DNA damage. The aim of this study was to evaluate the cytotoxicity and apoptotic/antigenotoxic effects of horchata as well as its mechanism. METHODS: Nine different varieties of horchata were prepared in the traditional way and then freeze-dried...
December 19, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29250491/human-primary-epithelial-cells-acquire-an-epithelial-mesenchymal-transition-phenotype-during-long-term-infection-by-the-oral-opportunistic-pathogen-porphyromonas-gingivalis
#20
Jungnam Lee, JoAnn S Roberts, Kalina R Atanasova, Nityananda Chowdhury, Kyudong Han, Özlem Yilmaz
Porphyromonas gingivalis is a host-adapted oral pathogen associated with chronic periodontitis that successfully survives and persists in the oral epithelium. Recent studies have positively correlated periodontitis with increased risk and severity of oral squamous cell carcinoma (OSCC). Intriguingly, the presence of P. gingivalis enhances tumorigenic properties independently of periodontitis and has therefore been proposed as a potential etiological agent for OSCC. However, the initial host molecular changes induced by P...
2017: Frontiers in Cellular and Infection Microbiology
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