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Mitomycin C

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https://www.readbyqxmd.com/read/29792974/patient-compliance-with-maintenance-intravesical-therapy-for-non-muscle-invasive-bladder-cancer
#1
Shlomi Tapiero, Alexander Helfand, Daniel Kedar, Ofer Yossepowitch, Andrei Nadu, Jack Baniel, David Lifshitz, David Margel
OBJECTIVE: To assess patient adherence to intravesical instillation therapy for non-muscle invasive urothelial carcinoma outside of clinical trials. METHODS: We reviewed the records of patients from 2000-2013 who received intravesical therapy for non-muscle invasive urothelial carcinoma. Patients with evidence of tumor recurrence or progression were excluded. We performed univariable and multivariable regression analysis to predict adherence to intravesical therapy...
May 21, 2018: Urology
https://www.readbyqxmd.com/read/29792536/outcomes-in-paediatric-external-dacryocystorhinostomy-a-single-centre-experience
#2
Tarjani Vivek Dave, Edak Ezeanosike, Milind N Naik, Mohammad Javed Ali
PURPOSE: To report the outcomes of external dacryocystorhinostomy (Ext DCR) in paediatric patients. METHODS: A single-centre, retrospective, interventional, non-comparative case series was performed on all paediatric patients who underwent Ext DCR between July 2010 and July 2014. Surgery was performed as per standard Ext DCR protocols with only anterior flap suturing. Data collected include demographics, clinical presentations, primary diagnosis, associated systemic anomalies, past interventions, indications for the surgery, use of adjuvants, intraoperative and post-operative complications, aetiology of DCR failure, anatomical and functional successes...
May 24, 2018: Orbit
https://www.readbyqxmd.com/read/29788478/a-minimal-threshold-of-fancj-helicase-activity-is-required-for-its-response-to-replication-stress-or-double-strand-break-repair
#3
Sanjay Kumar Bharti, Joshua A Sommers, Sanket Awate, Marina A Bellani, Irfan Khan, Lynda Bradley, Graeme A King, Yeonee Seol, Venkatasubramanian Vidhyasagar, Yuliang Wu, Takuye Abe, Koji Kobayashi, Kazuo Shin-Ya, Hiroyuki Kitao, Marc S Wold, Dana Branzei, Keir C Neuman, Robert M Brosh
Fanconi Anemia (FA) is characterized by bone marrow failure, congenital abnormalities, and cancer. Of over 20 FA-linked genes, FANCJ uniquely encodes a DNA helicase and mutations are also associated with breast and ovarian cancer. fancj-/- cells are sensitive to DNA interstrand cross-linking (ICL) and replication fork stalling drugs. We delineated the molecular defects of two FA patient-derived FANCJ helicase domain mutations. FANCJ-R707C was compromised in dimerization and helicase processivity, whereas DNA unwinding by FANCJ-H396D was barely detectable...
May 21, 2018: Nucleic Acids Research
https://www.readbyqxmd.com/read/29784662/ibuprofen-decreases-spontaneous-activity-and-enhances-nerve-evoked-contractions-to-minimise-mitomycin-c-induced-bladder-dysfunction
#4
Eliza G West, Ryan Lang, Donna Sellers, Russ Chess-Williams, Catherine M McDermott
Inflammation may play a causal role in urological side effects reported following intravesical mitomycin C (MMC). Our aim was to investigate the effects of the non-steroidal anti-inflammatory drug ibuprofen (IBU) on the cytotoxic potency of MMC and the potential for IBU to protect against bladder dysfunction. Malignant (RT4, T24) and normal (UROtsa) urothelial lines were treated with MMC followed by ibuprofen, with cell viability and caspase-3 activity assessed. Female C57BL/6JArc mice (Saline/Control, MMC, Saline + IBU and MMC + IBU), received intravesical treatment (1hr) with saline or MMC (2mg/mL), with IBU (1mg/mL) delivered in drinking water (for 7-days)...
May 21, 2018: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/29783948/expansion-of-the-sos-regulon-of-vibrio-cholerae-through-extensive-transcriptome-analysis-and-experimental-validation
#5
Evelyne Krin, Sebastian Aguilar Pierlé, Odile Sismeiro, Bernd Jagla, Marie-Agnès Dillies, Hugo Varet, Oihane Irazoki, Susana Campoy, Zoé Rouy, Stéphane Cruveiller, Claudine Médigue, Jean-Yves Coppée, Didier Mazel
BACKGROUND: The SOS response is an almost ubiquitous response of cells to genotoxic stresses. The full complement of genes in the SOS regulon for Vibrio species has only been addressed through bioinformatic analyses predicting LexA binding box consensus and in vitro validation. Here, we perform whole transcriptome sequencing from Vibrio cholerae treated with mitomycin C as an SOS inducer to characterize the SOS regulon and other pathways affected by this treatment. RESULTS: Comprehensive transcriptional profiling allowed us to define the full landscape of promoters and transcripts active in V...
May 21, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29781319/assessing-the-role-of-ranibizumab-in-improving-the-outcome-of-glaucoma-filtering-surgery-and-neovascular-glaucoma
#6
Andreas Katsanos, Kostantina Gorgoli, Dimitrios G Mikropoulos, Esther Arranz-Marquez, Georgios P Athanasopoulos, Miguel A Teus, Anastasios G P Konstas
Ranibizumab was the first anti-vascular endothelial growth factor (VEGF) agent approved for the treatment of neovascular age-related macular degeneration. The use of ranibizumab and other anti-VEGF medications in recent years has revolutionized the treatment of several sight-threatening retinal disorders. Emerging evidence has demonstrated that anti-VEGF treatment can offer advantages in the management of other ocular conditions where VEGFs play a key role: ocular scarring following glaucoma filtering surgery and neovascular glaucoma (NVG)...
May 19, 2018: Expert Opinion on Biological Therapy
https://www.readbyqxmd.com/read/29773904/methanol-fixed-fibroblasts-serve-as-feeder-cells-to-maintain-stem-cells-in-the-pluripotent-state-in-vitro
#7
Yahui Ren, Ziyu Ma, Tong Yu, Min Ling, Huayan Wang
Preparation of mouse embryonic fibroblast (MEF) feeder cells to maintain pluripotent stem cells (PSCs) is time consuming and involved in animal issues. Here, we demonstrated a novel method to prepare feeder cells with high efficiency, timesaving, and low costs. MEFs in 3 × 104 cell/cm2 were fixed by methanol for 5 min and air drying for 5 min. Thereafter, the methanol fixed MEF cells (MT-MEF) were able to be used directly to culture PSCs or stored at room temperature for the future usage. PSCs cultured on MT-MEF could be continuously expanded for over 40 passages with the naïve pluripotency...
May 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29773200/lithium-chloride-attenuates-mitomycin-c-induced-necrotic-cell-death-in-mda-mb-231-breast-cancer-cells-via-hmgb1-and-bax-signaling
#8
Mahdieh Razmi, Azra Rabbani-Chadegani, Fatemeh Hashemi-Niasari, Parinaz Ghadam
The clinical use of potent anticancer drug mitomycin C (MMC) has limited due to side effects and resistance of cancer cells. The aim of this study was to investigate whether lithium chloride (LiCl), as a mood stabilizer, can affect the sensitivity of MDA-MB-231 breast cancer cells to mitomycin C. The cells were exposed to various concentrations of mitomycin C alone and combined with LiCl and the viability determined by trypan blue and MTT assays. Proteins were analyzed by western blot and mRNA expression of HMGB1 MMP9 and Bcl-2 were analyzed by RT-PCR...
July 2018: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/29767247/comparison-of-the-synergistic-anticancer-activity-of-alpcs4-photodynamic-therapy-in-combination-with-different-low%C3%A2-dose-chemotherapeutic-agents-on-gastric-cancer-cells
#9
Jing Xin, Senhao Wang, Luwei Zhang, Bo Xin, Yulu He, Jing Wang, Sijia Wang, Lijian Shen, Zhenxi Zhang, Cuiping Yao
Limited cellular delivery and internalization efficiency of Al(III) phthalocyanine chloride tetrasulfonic acid (AlPcS4) induce poor penetration ability in cells and a slight photodynamic therapy (PDT) effect on gastric cancer. The combination treatment of AlPcS4/PDT with low‑dose chemotherapeutic agents may provide a promising treatment strategy to increase the weak delivery efficiency of AlPcS4, reducing the dose of chemical agents without reducing efficacy, and improving apoptosis‑inducing abilities, thereby increasing the antitumor effects and decreasing the noxious side effects on gastric cancer...
May 16, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29761828/differential-micronucleus-frequency-in-isogenic-human-cells-deficient-in-dna-repair-pathways-is-a-valuable-indicator-for-evaluating-genotoxic-agents-and-their-genotoxic-mechanisms
#10
Liton Kumar Saha, Sujin Kim, Habyeong Kang, Salma Akter, Kyungho Choi, Tetsushi Sakuma, Takashi Yamamoto, Hiroyuki Sasanuma, Kouji Hirota, Jun Nakamura, Masamitsu Honma, Shunichi Takeda, S Dertinger
The micronucleus (MN) test has become an attractive tool both for evaluating the genotoxicity of test chemicals because of its ability to detect clastogenic and aneugenic events and for its convenience. As the MN assay has been mostly performed using only DNA repair-proficient mammalian cells, we believed that the comparison of the MN frequency between DNA repair-proficient and -deficient human cells may be an excellent indicator for detecting the genotoxic potential of test chemicals and for understanding their mode of action...
May 15, 2018: Environmental and Molecular Mutagenesis
https://www.readbyqxmd.com/read/29755663/the-ongoing-challenge-of-large-anal-cancers-prospective-long-term-outcomes-of-intensity-modulated-radiation-therapy-with-concurrent-chemotherapy
#11
Ali Hosni, Kathy Han, Lisa W Le, Jolie Ringash, James Brierley, Rebecca Wong, Robert Dinniwell, Anthony Brade, Laura A Dawson, Bernard J Cummings, Monika K Krzyzanowska, Eric X Chen, David Hedley, Jennifer Knox, Alexandra M Easson, Patricia Lindsay, Tim Craig, John Kim
Purpose: Patterns of failure and long term outcomes were prospectively evaluated following tumor factors-stratified radiation dose for anal/perianal cancer. Methods: Between 2008-2013, patients with anal/perianal squamous cell carcinoma were accrued to an institutional REB-approved prospective study. All patients were treated with image-guided intensity-modulated radiation therapy (IG-IMRT). Radiation dose selection (27-36 Gy for elective target, and 45-63 Gy for gross target) was based on tumor clinico-pathologic features...
April 17, 2018: Oncotarget
https://www.readbyqxmd.com/read/29745935/-sequential-treatment-with-mitomycin-c-and-bcg-in-non-muscle-invasive-bladder-cancer
#12
Venancio Chantada-Abal, Cristina Chantada-Tirado, Leticia Lamas-Díaz, Francisco Caramés-Masana, Anselmo Damián Villegas-Piguave, Nuria Villar-Vázquez
Bacilus Calmette-Guerin (BCG) administered intravesical is an effective therapy in non muscle invasive bladder cancer (NMIBC), but it presents limitations regarding recurrence and toxicity. For years, many case series have been published where sequential therapy with BCG and Mitomycin C (MMC) was tried. In this article, we perform a review of the data supplied by these articles with the aim to determine the safety and efficacy of combination, and what is the group of patients it should be indicated. Many studies show that combination therapy did not cause more toxicity and improved the interval free of disease with decrease of tumor progression compared to BCG or MMC monotherapy...
May 2018: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/29745932/analysis-of-tolerance-and-security-of-chemo-hyperthermia-with-mitomycin-c-for-the-treatment-of-non-muscle-invasive-bladder-cancer
#13
Juan León-Mata, José Luis Domínguez, Joan Palou Redorta, Daniel Sousa González, María Alvarez Casal, Alejandro Sousa Escandón, Eva Piñeiro Vázquez
OBJECTIVES: The treatment of non muscle invasive bladder cancer (NMIBC) continues to be a challenge. Hyperthermia (HT) combined with intravesical chemotherapy is used to enhance the effects of chemotherapy. METHODS: A review of the publications was carried out to synthesize the adverse effects (AE) reported by the use of chemohyperthermia (QHT) with Mitomycin-C (MMC). The most relevant data are exposed for each of the devices currently used in the QHT. RESULTS: SYNERGO®: The dropout rate varied between 3-40%, and the AE rate is up to 88%...
May 2018: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/29745931/-mitomycin-c-hivec-update-and-results-in-high-risk-patients
#14
Félix Guerrero-Ramos, Daniel Castellano-Gauna, Esther García-Rojo, José Manuel Duarte-Ojeda, Federico de la Rosa-Kehrmann, Felipe Villacampa-Aubá
Adjuvant endovesical treatment is a research field in constant exploration with the aim to minimize the risk of recurrence and progression of non muscle invasive bladder tumors. Over the last years, the administration of chemotherapy in a chemo hyperthermia regimen has been added to the existing regimens. There are various systems for its administration, but this article focus on HIVEC (Hyperthermic IntraVEsical Chemotherapy) and its current status. In this review article we update the results of this system in the case-scenarios it has been used (preoperative with ablative intention and as adjuvant therapy with prophylactic purposes), tolerance and security issues, on-going clinical trials and future perspectives...
May 2018: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/29745929/-chemohyperthermia-using-mmc-in-non-muscle-invasive-bladder-cancer-current-status-and-future-perspectives
#15
Jacqueline J M J H Coenen, F Johannes P van Valenberg, Tom J H Arends, J Alfred Witjes
In an effort to decrease recurrence and progression rates in non-muscle-invasive bladder cancer (NMIBC), transurethral resection of a bladder tumor is followed by intravesical instillations using Mitomycin-C (MMC) and Bacillus Calmette-Guérin (BCG). In spite of these adjuvant treatment modalities, recurrence and progression rates remain high. Because of these limitations of current standard therapy and the shortage of BCG, there is a search for alternative forms of treatment in NMIBC. Intravesical MMC combined with hyperthermia, especially RF-induced QHT being most extensively investigated in the past 20 years, is one of these alternatives for intermediate- and high-risk NMIBC...
May 2018: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/29745927/-new-endovesical-chemotherapy-drugs-and-application-vehicles
#16
Emilio Rios González, Luis Martínez-Piñeiro
Urothelial bladder cancer is a very prevalent disease. At the time of diagnosis 70-80% of the cases present as non muscle invasive tumors. These tumors present a high recurrence and progression rates despite intravesical treatment with Bacille Calmette-Guerin and mitomycin C. Moreover, bladder conditions such as its wall impermeability and the fact that intravesical drugs are constantly being diluted by urine and eliminated do not favor the efficacy of intravesical treatment. This review analyzes new intravesical drugs such as gemcitabine or taxanes with promising results as alternative to the usual treatments or after their failure...
May 2018: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/29745926/-immediate-post-turbt-mmc-instillation
#17
José Luis Domínguez-Escrig
Mitomycin C is an antitumor alkylating antibiotic agent that inhibits DNA synthesis extensively used as intravesical chemotherapy agent in the adjuvant treatment of urothelial carcinoma. Its clinical efficacy is the context of single early postoperative instillation was demonstrated by Toley et al. in 1988. Since then, multiple clinical trials and 4 metanalyses have endorsed its use with level 1a evidence. The objective of this chapter is to perform a comprehensive updated review on the use of MMC in the context of single early instillation at the time of TURBT, the available clinical evidence, most relevant recommendations in the international clinical guidelines, its complications and potential maneuvers for the optimization of its use...
May 2018: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/29745096/cytoreduction-and-hipec-for-peritoneal-carcinomatosis-of-pancreatic-cancer
#18
Antonios-Apostolos Tentes, Nicolaos Pallas, Christina Karamveri, Dimitrios Kyziridis, Christos Hristakis
PURPOSE: Peritoneal carcinomatosis of pancreatic cancer is generally considered for palliative treatment. The purpose of this study was to report the outcome of cytoreductive surgery and hyperthermic intraoperative intraperitoneal chemotherapy (HIPEC) in patients with pancreatic cancer and peritoneal carcinomatosis. METHODS: Patients with documented resectable peritoneal carcinomatosis of pancreatic cancer underwent cytoreductive surgery in combination with HIPEC from 2008-2016 by the same surgical team...
March 2018: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29733076/age-does-not-matter-the-relevance-of-immediate-instillation-therapy-with-mitomycin-c-in-non-muscle-invasive-bladder-cancer
#19
EDITORIAL
Frank Christoph, Martin Schostak
No abstract text is available yet for this article.
April 2018: Translational Andrology and Urology
https://www.readbyqxmd.com/read/29730950/emerging-intravesical-drugs-for-the-treatment-of-non-muscle-invasive-bladder-cancer
#20
Jasper Crijnen, Theo M de Reijke
Bladder cancer (BC) is a severe health burden: it is the fifth most common malignancy in the world and has high recurrence and progression rates. Standard treatment starts with TURB followed by intravesical chemotherapy with Mitomycin C or immunotherapy with BCG. However, successful management still remains a challenge, because approximately 30% of patients have recurrence or progression within 5 years, and treatment has considerable side effects. Anticipating on the upcoming BCG shortage emphasizes, moreover, the necessity to develop and study novel treatments...
May 5, 2018: Expert Opinion on Emerging Drugs
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