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https://www.readbyqxmd.com/read/28644914/the-role-of-expectation-in-multisensory-body-representation-neural-evidence
#1
Francesca Ferri, Ettore Ambrosini, Paola Pinti, Arcangelo Merla, Marcello Costantini
Sensory events contribute to body ownership, the feeling that the body belongs to me. However, the encoding of sensory events is not only reactive, but also proactive in that our brain generates prediction about forthcoming stimuli. In previous studies we have shown that prediction of sensory events is a sufficient condition to induce the sense of body ownership. In this study we investigate the underlying neural mechanisms. Participants were seated with their right arm resting upon a table just below another smaller table...
June 23, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/28641100/bruton-s-tyrosine-kinase-btk-as-a-promising-target-in-solid-tumors
#2
REVIEW
J Molina-Cerrillo, T Alonso-Gordoa, P Gajate, E Grande
Bruton's tyrosine kinase (BTK) is a non-receptor intracellular kinase that belongs to the TEC-family tyrosine kinases together with bone marrow-expressed kinase (BMX), redundant-resting lymphocyte kinase (RLK), and IL-2 inducible T-Cell kinase (ITK). All these proteins play a key role in the intracellular signaling of both B and T lymphocytes. Recently, some preclinical data have demonstrated that BTK is present in certain tumor subtypes and in other relevant cells that are contributing to the tumor microenvironment such as dendritic cells, macrophages, myeloid derived suppressor cells and endothelial cells...
June 9, 2017: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/28641061/positive-parenting-as-responsible-care-risks-protective-factors-and-intervention-evaluation
#3
Silvia Donato, Anna Bertoni
In this themed issue of the Journal of Prevention & Intervention in the Community, the first four contributions provide knowledge on factors that can support or hinder positive parenting throughout children's lives. In particular, the first article examined the spillover of work stressors on parenting behaviors and the role of spousal support as a moderator of stress spillover. The second contribution examines the association between parents' promotion of volitional functioning and adopted children's sense of strength of family bonds and belonging to the adoptive family...
July 2017: Journal of Prevention & Intervention in the Community
https://www.readbyqxmd.com/read/28640851/ligand-mediated-and-tertiary-interactions-cooperatively-stabilize-the-p1-region-in-the-guanine-sensing-riboswitch
#4
Christian A Hanke, Holger Gohlke
Riboswitches are genetic regulatory elements that control gene expression depending on ligand binding. The guanine-sensing riboswitch (Gsw) binds ligands at a three-way junction formed by paired regions P1, P2, and P3. Loops L2 and L3 cap the P2 and P3 helices and form tertiary interactions. Part of P1 belongs to the switching sequence dictating the fate of the mRNA. Previous studies revealed an intricate relationship between ligand binding and presence of the tertiary interactions, and between ligand binding and influence on the P1 region...
2017: PloS One
https://www.readbyqxmd.com/read/28625085/enjoyable-company-in-sharing-stroke-experiences-lifestyle-groups-after-stroke
#5
Anne Lund, Mali Melhus, Unni Sveen
BACKGROUND: Even people with mild to moderate stroke will experience changes in their abilities to perform everyday occupations. Group interventions may be appropriate in late-stage rehabilitation. The aim of this study was to explore how the participants involved themselves in person-centered lifestyle groups after stroke in Norway. METHOD: Semi-structured interviews were performed with six older adults with mild-to-moderate stroke who had participated in lifestyle groups over a period of nine months...
June 19, 2017: Scandinavian Journal of Occupational Therapy
https://www.readbyqxmd.com/read/28615947/treatment-of-secondary-hyperparathyroidism-the-clinical-utility-of-etelcalcetide
#6
REVIEW
Mario Cozzolino, Andrea Galassi, Ferruccio Conte, Michela Mangano, Luca Di Lullo, Antonio Bellasi
Secondary hyperparathyroidism (SHPT), a very frequent, severe, and worsening complication of chronic kidney disease, is characterized by high serum parathyroid hormone (PTH), parathyroid gland hyperplasia, and disturbances in mineral metabolism. Clinically, SHPT shows renal osteodystrophy, vascular calcification, cardiovascular damage, and fatal outcome. Calcium-sensing receptor (CaSR) is the main physiological regulator of PTH secretion; its activation by calcium rapidly inhibits PTH. Another important player in regulating mineral metabolism is vitamin D receptor (VDR), which is under the influence of vitamin D and influences the intestinal absorption of calcium and phosphate, PTH gene expression, and bone calcium mobilization...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/28613107/the-role-of-arts-activities-in-developing-resilience-and-mental-wellbeing-in-children-and-young-people-a-rapid-review-of-the-literature
#7
Leyre Zarobe, Hilary Bungay
AIMS: This rapid review explores the role of arts activities in promoting the mental wellbeing and resilience of children and young people aged between 11 and 18 years. METHODS: A systematic search of the literature was undertaken across 18 databases; no date limit was set on publication. Search terms included a range of creative activities: music, dance, singing, drama and visual arts; these were combined with terms linked to aspects of mental health, emotional wellbeing and resilience...
June 1, 2017: Perspectives in Public Health
https://www.readbyqxmd.com/read/28610759/how-architectural-design-affords-experiences-of-freedom-in-residential-care-for-older-people
#8
Iris Van Steenwinkel, Bernadette Dierckx de Casterlé, Ann Heylighen
Human values and social issues shape visions on dwelling and care for older people, a growing number of whom live in residential care facilities. These facilities' architectural design is considered to play an important role in realizing care visions. This role, however, has received little attention in research. This article presents a case study of a residential care facility for which the architects made considerable effort to match the design with the care vision. The study offers insights into residents' and caregivers' experiences of, respectively, living and working in this facility, and the role of architectural features therein...
April 2017: Journal of Aging Studies
https://www.readbyqxmd.com/read/28610140/three-new-i-batillipes-i-species-arthrotardigrada-batillipedidae-from-the-brazilian-coast
#9
Erika Santos, Clélia M C DA Rocha, Edivaldo Jr Gomes, Paulo Fontoura
Three new tardigrade species, Batillipes brasiliensis sp. nov., Batillipes dandarae sp. nov. and Batillipes potiguarensis sp. nov., are described from shallow subtidal sediments of the Brazilian coast. B. brasiliensis sp. nov. and B. dandarae sp. nov. have toes 3 and 4 on leg IV different in length, so they can be included in the D group of species, while B. potiguarensis sp. nov., with toes 3 and 4 on leg IV equal in length belong to the A group. Batillipes brasiliensis sp. nov. is characterized by having an ala-like caudal expansion; cuticular projections on the coxal region of legs I-III, and lateral projections...
March 16, 2017: Zootaxa
https://www.readbyqxmd.com/read/28604245/state-of-the-art-or-the-art-of-medicine-transnational-mobility-and-perceptions-of-multiple-biomedicines-among-nigerian-physicians-in-the-u-s
#10
Judith Schühle
Over the last 40 years, several thousand Nigerian-trained doctors have migrated to the U.S. to practice in what they regard as the state-of-the-art of global biomedicine. Based on interviews with Nigerian physicians, this article shows how their professional mobility, and their transition to the new professional environment of U.S. biomedicine, makes them aware of local differences in practicing medicine. Adapting to local ways of practicing in the U.S. creates a new sense of belonging and professional identity...
June 12, 2017: Global Public Health
https://www.readbyqxmd.com/read/28595441/healing-spirituality-and-integrative-medicine
#11
David M Steinhorn, Jana Din, Angela Johnson
Spirituality plays a prominent role in the lives of most palliative patients whether or not they formally adhere to a specific religion and belief. As a result, the palliative care team is frequently called upon to support families who are experiencing their "dark night of the soul" and struggling to make sense of their lives during a healthcare crisis. While conventional religious practices provide a source of comfort and guidance for many of our patients, a significant number of our patients do not have a strong religious community to which to turn...
May 22, 2017: Annals of Palliative Medicine
https://www.readbyqxmd.com/read/28589512/molecular-insights-into-rna-binding-properties-of-escherichia-coli-expressed-rna-dependent-rna-polymerase-of-antheraea-mylitta-cytoplasmic-polyhedrosis-virus
#12
Anirban Kundu, Madhuparna Bose, Madhurima Roy, Soumita Dutta, Poulomi Biswas, Pradeep Gautam, Amit Kumar Das, Ananta Kumar Ghosh
Antheraea mylitta cytoplasmic polyhedrosis virus (AmCPV) is responsible for morbidity of the Indian non-mulberry silkworm, A. mylitta. AmCPV belongs to the family Reoviridae and has 11 double-stranded (ds) RNA genome segments (S1-S11). Segment 2 (S2) encodes a 123-kDa polypeptide with RNA-dependent RNA polymerase (RdRp) activity. To examine the RNA-binding properties of the viral polymerase, the full-length RdRp and its three domains (N-terminal, polymerase and C-terminal domains) were expressed in Escherichia coli BL21 (DE3) cells with hexahistidine and trigger factor tag fused consecutively at its amino terminus, and the soluble fusion proteins were purified...
June 6, 2017: Archives of Virology
https://www.readbyqxmd.com/read/28585432/full-genome-analysis-of-swine-genotype-3-hepatitis-e-virus-isolated-from-eastern-china
#13
Jiang-Bing Shuai, Lu-Huan Li, Ai-Yun Li, Yong-Qiang He, Xiao-Feng Zhang
Hepatitis E is believed to occur in both endemic and sporadic forms in developing countries, which causes a major public health problem in Asia and Africa (Meng, 2010; Wang et al., 2016a). Recent studies have documented that the disease is also endemic in many industrialized countries (Wenzel et al., 2011). The causative agent, hepatitis E virus (HEV), belonging to the genus Orthohepevirus, is a non-enveloped RNA virus with a single-stranded, positive-sense genome of approximately 7.2 kb (Smith et al., 2014)...
June 2017: Journal of Zhejiang University. Science. B
https://www.readbyqxmd.com/read/28580677/lgbtq-youth-s-views-on-gay-straight-alliances-building-community-providing-gateways-and-representing-safety-and-support
#14
Carolyn M Porta, Erin Singer, Christopher J Mehus, Amy L Gower, Elizabeth Saewyc, Windy Fredkove, Marla E Eisenberg
BACKGROUND: Gay-Straight Alliances (GSAs) are school-based clubs that can contribute to a healthy school climate for lesbian, gay, bisexual, transgender, and questioning (LGBTQ) youth. While positive associations between health behaviors and GSAs have been documented, less is known about how youth perceive GSAs. METHODS: A total of 58 LGBTQ youth (14-19 years old) mentioned GSAs during go-along interviews in 3 states/provinces in North America. These 446 comments about GSAs were thematically coded and organized using Atlas...
July 2017: Journal of School Health
https://www.readbyqxmd.com/read/28580560/-a-symbol-of-connectedness-between-the-self-and-the-tribal-home-betel-quid-in-the-lives-of-indigenous-taiwanese
#15
Wei-Fen Ma, Chia-Ing Li, Ellen R Gritz, Irene Tamí-Maury, Cho Lam, Cheng-Chieh Lin
BACKGROUND: Betel quid chewing plays a significant role in the development of oral cancer, yet the high prevalence of betel quid use remains a serious health problem in Taiwan, especially among indigenous Taiwanese. PURPOSE: The present study aimed to understand the reasons behind betel-quid chewing among indigenous Taiwanese people by examining the larger context of their culture and traditions. METHODS: This descriptive, qualitative study recruited ten regular betel quid indigenous chewers using purposive and snowball sampling...
June 2017: Hu Li za Zhi the Journal of Nursing
https://www.readbyqxmd.com/read/28579969/ten-years-toward-equity-preliminary-results-from-a-follow-up-case-study-of-academic-computing-culture
#16
Tanya L Crenshaw, Erin W Chambers, Cinda Heeren, Heather E Metcalf
Just over 10 years ago, we conducted a culture study of the Computer Science Department at the flagship University of Illinois at Urbana-Champaign, one of the top five computing departments in the country. The study found that while the department placed an emphasis on research, it did so in a way that, in conjunction with a lack of communication and transparency, devalued teaching and mentoring, and negatively impacted the professional development, education, and sense of belonging of the students. As one part of a multi-phase case study spanning over a decade, this manuscript presents preliminary findings from our latest work at the university...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28577341/the-malate-sensing-two-component-system-maekr-is-a-non-canonical-class-of-sensory-complex-for-c4-dicarboxylates
#17
L Miguel-Romero, P Casino, J M Landete, V Monedero, M Zúñiga, A Marina
Microbial colonization of different environments is enabled to a great extent by the plasticity of their sensory mechanisms, among them, the two-component signal transduction systems (TCS). Here, an example of TCS plasticity is presented: the regulation of L-malate catabolism via malic enzyme by MaeRK in Lactobacillales. MaeKR belongs to the citrate family of TCS as the Escherichia coli DcuSR system. We show that the Lactobacillus casei histidine-kinase MaeK is defective in autophosphorylation activity as it lacks a functional catalytic and ATP binding domain...
June 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28576370/leuconostoc-strains-isolated-from-dairy-products-response-against-food-stress-conditions
#18
Luisa D'Angelo, Joaquín Cicotello, Miriam Zago, Daniela Guglielmotti, Andrea Quiberoni, Viviana Suárez
A systematic study about the intrinsic resistance of 29 strains (26 autochthonous and 3 commercial ones), belonging to Leuconostoc genus, against diverse stress factors (thermal, acidic, alkaline, osmotic and oxidative) commonly present at industrial or conservation processes were evaluated. Exhaustive result processing was made by applying one-way ANOVA, Student's test (t), multivariate analysis by Principal Component Analysis (PCA) and Matrix Hierarchical Cluster Analysis. In addition, heat adaptation on 4 strains carefully selected based on previous data analysis was assayed...
September 2017: Food Microbiology
https://www.readbyqxmd.com/read/28574374/nitrophorins-and-nitrobindins-structure-and-function
#19
REVIEW
Giovanna De Simone, Paolo Ascenzi, Alessandra di Masi, Fabio Polticelli
Classical all α-helical globins are present in all living organisms and are ordered in three lineages: (i) flavohemoglobins and single domain globins, (ii) protoglobins and globin coupled sensors and (iii) truncated hemoglobins, displaying the 3/3 or the 2/2 all α-helical fold. However, over the last two decades, all β-barrel and mixed α-helical-β-barrel heme-proteins displaying heme-based functional properties (e.g. ligand binding, transport and sensing) closely similar to those of all α-helical globins have been reported...
May 24, 2017: Biomolecular Concepts
https://www.readbyqxmd.com/read/28572178/evaluating-psychosocial-mechanisms-underlying-stem-persistence-in-undergraduates-evidence-of-impact-from-a-six-day-pre-college-engagement-stem-academy-program
#20
Danielle Findley-Van Nostrand, Richard S Pollenz
The persistence of undergraduate students in science, technology, engineering, and mathematics (STEM) disciplines is a national issue based on STEM workforce projections. We implemented a weeklong pre-college engagement STEM Academy (SA) program aimed at addressing several areas related to STEM retention. We validated an instrument that was developed based on existing, validated measures and examined several psychosocial constructs related to STEM (science identity, self-efficacy, sense of belonging to the university and to STEM, career expectancies, and intention to leave STEM majors) before and after the program...
2017: CBE Life Sciences Education
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