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sense of belonging

Shruti Shukla, Yuvaraj Haldorai, Vivek K Bajpai, Arunkumar Rengaraj, Seung Kyu Hwang, Xinjie Song, Myunghee Kim, Yun Suk Huh, Young-Kyu Han
A sensitive electrochemical immunosensing platform for the detection of Cronobacter sakazakii was developed using a graphene oxide/gold (GO/Au) composite. Transmission electron microscopy showed that the Au nanoparticles, with an average size of < 30 nm, were well dispersed on the GO surface. For the detection of C. sakazakii, a polyclonal anti-C. sakazakii antibody (IgG) was covalently immobilized to the Au nanoparticles on the surface of the GO/Au composite coated glassy carbon electrode (GCE). The electrochemical sensing performance of immunofunctionalized GCE was characterized by cyclic voltammetry and differential pulse voltammetry...
March 8, 2018: Biosensors & Bioelectronics
Frederic von Wegner, Helmut Laufs, Enzo Tagliazucchi
Long-range memory in time series is often quantified by the Hurst exponent H, a measure of the signal's variance across several time scales. We analyze neurophysiological time series from electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) resting state experiments with two standard Hurst exponent estimators and with the time-lagged mutual information function applied to discretized versions of the signals. A confidence interval for the mutual information function is obtained from surrogate Markov processes with equilibrium distribution and transition matrix identical to the underlying signal...
February 2018: Physical Review. E
Olivier Poupel, Caroline Proux, Bernd Jagla, Tarek Msadek, Sarah Dubrac
The success of Staphylococcus aureus, as both a human and animal pathogen, stems from its ability to rapidly adapt to a wide spectrum of environmental conditions. Two-component systems (TCSs) play a crucial role in this process. Here, we describe a novel staphylococcal virulence factor, SpdC, an Abi-domain protein, involved in signal sensing and/or transduction. We have uncovered a functional link between the WalKR essential TCS and the SpdC Abi membrane protein. Expression of spdC is positively regulated by the WalKR system and, in turn, SpdC negatively controls WalKR regulon genes, effectively constituting a negative feedback loop...
March 2018: PLoS Pathogens
Jiyoung Hwang, Lisa Wang, Jodi Siever, Talia Del Medico, Charlotte A Jones
OBJECTIVES: Loneliness and social isolation (L&SI) are associated with physical and cognitive decline in older adults. Walk 'n' Talk for your Life (WTL) is a community-based program of socialization, health education, falls prevention exercise and walking for community-dwelling older adults. This qualitative study was done to gain further insight into the experience and impacts of the WTL on seniors' L&SI. METHODS: One-on-one semi-structured interviews were conducted with sixteen participants who had completed the WTL ...
March 15, 2018: Aging & Mental Health
Neeraja Purandare, Mallika Somayajulu, Maik Hüttemann, Lawrence I Grossman, Siddhesh Aras
Coiled-coil-helix-coiled-coil-helix domain-containing 10 (CHCHD10) and CHCHD2 (MNRR1) are homologous proteins with 58% sequence identity and belong to the twin CX9C family of proteins that mediate cellular stress responses. Despite the identification of several neurodegeneration-associated mutations in the CHCHD10 gene, few studies have assessed its physiological role. Here, we investigated CHCHD10's function as a regulator of oxidative phosphorylation in the mitochondria and the nucleus. We show that CHCHD10 co-purifies with cytochrome c oxidase (COX) and up-regulates COX activity by serving as a scaffolding protein required for MNRR1 phosphorylation, mediated by ARG (ABL proto-oncogene 2, non-receptor tyrosine kinase [ABL2])...
March 14, 2018: Journal of Biological Chemistry
Susan Williams, Mallory Schneider, Cory Wornell, Jennifer Langhinrichsen-Rohling
This study examined the relationship of students' perceptions of school safety and school avoidance related to feeling unsafe with predictor variables: bullying victimization, student/teacher/parent/administration relations, rule clarity and consistency, school physical environment (negative and positive), and student's belongingness. In a public high school sample ( n = 585), 24.7% of students felt unsafe and 14.4% avoided school due to feeling unsafe during the past month. Being female and experiencing bullying was associated with feeling unsafe...
January 1, 2018: Journal of School Nursing: the Official Publication of the National Association of School Nurses
Ann Sheridan, Donal O'Keeffe, Barbara Coughlan, Kate Frazer, Johnathan Drennan, Mary Kemple
BACKGROUND: Social opportunities can be limited in the lives of people with enduring mental illness (EMI) due to psychiatric stigma, restricted home environments and employment barriers. Supported socialisation programmes have the potential to redress the impact of social isolation. AIM: To explore the experiences of service users with EMI taking part in a supported socialisation programme, using written diary entries. METHODS: This article reports on the qualitative component of a randomised controlled trial of supported socialisation for people with EMI (published previously in this journal)...
March 1, 2018: International Journal of Social Psychiatry
David Portehault, Simon Delacroix, Guillaume Gouget, Rémi Grosjean, Tsou-Hsi-Camille Chan-Chang
The design of inorganic nanoparticles relies strongly on the knowledge from solid-state chemistry not only for characterization techniques, but also and primarily for choosing the systems that will yield the desired properties. The range of inorganic solids reported and studied as nanoparticles is however strikingly narrow when compared to the solid-state chemistry portfolio of bulk materials. Efforts to enlarge the collection of inorganic particles are becoming increasingly important for three reasons. First, they can yield materials more performing than current ones for a range of fields including biomedicine, optics, catalysis, and energy...
March 13, 2018: Accounts of Chemical Research
Jaana Juvonen, Leah M Lessard, Hannah L Schacter, Craig Enders
This study examines whether social-emotional difficulties associated with higher body weight vary across schools as a function of the school's weight climate. Weight climate, characterized by weight-policing, was assessed indirectly by examining how strongly self-reported weight predicts victim reputation within 26 ethnically diverse middle schools. Social-emotional indicators included self-reported loneliness, school belonging, and self-esteem. In schools with stronger weight-policing at seventh grade, loneliness was intensified by eighth grade among both girls (n = 2,101) and boys (n = 1,985) with higher weight...
March 13, 2018: Journal of Research on Adolescence: the Official Journal of the Society for Research on Adolescence
Pamela van der Riet, Tracy Levett-Jones, Helen Courtney-Pratt
Clinical placements are specifically designed to facilitate authentic learning opportunities and are an integral component of undergraduate nursing programs. However, as academics and clinicians frequently point out, clinical placements are fraught with problems that are long-standing and multidimensional in nature. Collaborative placement models, grounded in a tripartite relationship between students, university staff and clinical partners, and designed to foster students' sense of belonging, have recently been implemented to address many of the challenges associated with clinical placements...
March 1, 2018: Nurse Education in Practice
Catarina Magalhães Dahl, Flávia Mitkiewicz de Souza, Giovanni Marcos Lovisi, Ezra Susser, Maria Tavares Cavalcanti
Narratives play a fundamental role in the recovery of persons with schizophrenia, mainly from the paradigmatic change engendered by the recovery movement. Rather than a methodological tool or a byproduct of recovery, narratives are integral components of this process. This article aims to analyze overcoming narratives, in the light of the corporeality paradigm, based on an emblematic case of a peer support worker. This is a qualitative study carried out in the context of a randomized clinical trial, and it is based on one in-depth interview and focus groups for the construction of the narrative...
November 2017: Vertex: Revista Argentina de Psiquiatriá
Roberta Lynn Woodgate, David Shiyokha Busolo
BACKGROUND: African Immigrant and refugee youth represent an increasing group of newcomers in Canada. Upon their immigration, youth experience challenges that have the potential to lead to poor health, yet little is known about their settlement journey. Accordingly, this qualitative study examines the settlement journey of African immigrant and refugee youth with a focus on how their experiences were shaped by the social determinants of health. METHODS: We conducted a total of 70 interviews with 52 immigrant and refugee youth (ages 13-29 years) who had arrived in Canada in the preceding six years...
March 7, 2018: BMC Public Health
Maria Chiu, Abigail Amartey, Xuesong Wang, Paul Kurdyak
BACKGROUND: The purpose of this study was to compare the prevalence of self-reported mental health factors, mental health service use, and unmet needs across the 4 largest ethnic groups in Ontario, Canada: white, South Asian, Chinese, and black groups. METHODS: The study population was derived from the Canadian Community Health Survey, using a cross-sectional sample of 254,951 white, South Asian, Chinese, and black residents living in Ontario, Canada, between 2001 and 2014...
January 1, 2018: Canadian Journal of Psychiatry. Revue Canadienne de Psychiatrie
Atsukazu Kuwahara, Yuko Kuwahara, Toshio Inui, Yoshinori Marunaka
The diffuse chemosensory system (DCS) is well developed in the apparatuses of endodermal origin like gastrointestinal (GI) tract. The primary function of the GI tract is the extraction of nutrients from the diet. Therefore, the GI tract must possess an efficient surveillance system that continuously monitors the luminal contents for beneficial or harmful compounds. Recent studies have shown that specialized cells in the intestinal lining can sense changes in the luminal content. The chemosensory cells in the GI tract belong to the DCS which consists of enteroendocrine and related cells...
March 5, 2018: International Journal of Molecular Sciences
Nusratnaaz M Shaikh, Paula Kersten, Richard J Siegert, Alice Theadom
PURPOSE: Despite increasing emphasis on the importance of community integration as an outcome for acquired brain injury (ABI), there is still no consensus on the definition of community integration. The aim of this study was to complete a concept analysis of community integration in people with ABI. MATERIALS AND METHODS: The method of concept clarification was used to guide concept analysis of community integration based on a literature review. Articles were included if they explored community integration in people with ABI...
March 6, 2018: Disability and Rehabilitation
Osvaldo Filipe, David De Vleesschauwer, Ashley Haeck, Kristof Demeestere, Monica Höfte
Sucrose non-fermenting-1-related protein kinase-1 (SnRK1) belongs to a family of evolutionary conserved kinases with orthologs in all eukaryotes, ranging from yeasts (SnF1) to mammals (AMP-Activated kinase). These kinases sense energy deficits caused by nutrient limitation or stress and coordinate the required adaptations to maintain energy homeostasis and survival. In plants, SnRK1 is a global regulator of plant metabolism and is also involved in abiotic stress responses. Its role in the response to biotic stress, however, is only starting to be uncovered...
March 1, 2018: Scientific Reports
Stefano Motta, Claudia Minici, Dario Corrada, Laura Bonati, Alessandro Pandini
Hypoxia inducible factors (HIFs) are transcription factors belonging to the basic helix-loop-helix PER-ARNT-SIM (bHLH-PAS) protein family with a role in sensing oxygen levels in the cell. Under hypoxia, the HIF-α degradation pathway is blocked and dimerization with the aryl hydrocarbon receptor nuclear translocator (ARNT) makes HIF-α transcriptionally active. Due to the common hypoxic environment of tumors, inhibition of this mechanism by destabilization of HIF-α:ARNT dimerization has been proposed as a promising therapeutic strategy...
February 28, 2018: PLoS Computational Biology
Kimiko Tanaka, Larry Davidson, Thomas J Craig
BACKGROUND: While the neighborhood community literature well documents a link between participation in supportive and effective community groups or activities and empowerment, there is as yet little empirical evidence of this relationship in the context of community mental health programs. AIM: The primary purpose of the study was to examine the relationship between sense of community belonging and empowerment among members of mental health clubhouses. METHODS: A secondary analysis using a hierarchical regression model was conducted on cross-sectional structured interview data collected through a self-report questionnaire from 102 clubhouse members from six clubhouses in the United States and Finland...
February 1, 2018: International Journal of Social Psychiatry
Matheus D Baldissera, Carine F Souza, Jaqueline I Golombieski, Débora Seben, Letícia R Sippert, Joseânia Salbego, Enio Marchesan, Renato Zanella, Bernardo Baldisserotto
Thiamethoxam is a broad-spectrum pesticide widely used in agricultural practice throughout the world. Worryingly, this pesticide is considered a potential contaminant on the surface and underground water, being a significant risk to aquatic ecosystems and humans. In this sense, we decided to evaluate the activity of enzymes belonging to purinergic system, which is linked with regulation of extracellular nucleotides and nucleosides, as adenosine triphosphate (ATP) and adenosine (Ado) molecules involved in the regulation of immune and inflammatory responses...
February 26, 2018: Molecular and Cellular Biochemistry
Melanie Lovatt
Residential homes encourage new residents to bring belongings with them, so that they can personalise their room and 'feel at home'. Existing literature on material culture in residential homes views objects as symbols and repositories of home and identity, which can facilitate a sense of belonging in residents through their display in residents' rooms. I suggest that this both misunderstands the processual and fluid nature of home and identity, and conceptualises objects as essentially passive. This article uses ethnographic data and theories of practice and relationality to argue that rather than the meaning of home being inherent in objects, or felt subjectively by residents, meaning is generated through ongoing, everyday interactions between the two...
February 2018: Sociology of Health & Illness
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