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https://www.readbyqxmd.com/read/28208598/neighborhood-environment-and-falls-among-community-dwelling-older-adults
#1
Emily Joy Nicklett, Matthew C Lohman, Matthew Lee Smith
Background: Falls present a major challenge to active aging, but the relationship between neighborhood factors and falls is poorly understood. This study examined the relationship between fall events and neighborhood factors, including neighborhood social cohesion (sense of belonging, trust, friendliness, and helpfulness) and physical environment (vandalism/graffiti, rubbish, vacant/deserted houses, and perceived safety walking home at night). Methods: Data were analyzed from 9259 participants over four biennial waves (2006-2012) of the Health and Retirement Study (HRS), a nationally representative sample of adults aged 65 and older in the United States...
February 10, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28193786/bile-acids-potentiate-proton-activated-currents-in-xenopus-laevis-oocytes-expressing-human-acid-sensing-ion-channel-asic1a
#2
Alexandr V Ilyaskin, Alexei Diakov, Christoph Korbmacher, Silke Haerteis
Acid-sensing ion channels (ASICs) are nonvoltage-gated sodium channels transiently activated by extracellular protons and belong to the epithelial sodium channel (ENaC)/Degenerin (DEG) family of ion channels. Bile acids have been shown to activate two members of this family, the bile acid-sensitive ion channel (BASIC) and ENaC. To investigate whether bile acids also modulate ASIC function, human ASIC1a was heterologously expressed in Xenopus laevis oocytes. Exposing oocytes to tauro-conjugated cholic (t-CA), deoxycholic (t-DCA), and chenodeoxycholic (t-CDCA) acid at pH 7...
February 2017: Physiological Reports
https://www.readbyqxmd.com/read/28190937/belonging-and-unbelonging-jewish-refugee-and-survivor-women-in-1950s-britain
#3
Angela Davis
This article analyses the life stories of female Jewish refugees and survivors in 1950s Britain in order to explore their relationship with the existing Jewish community and wider society. The paper is based on an analysis of twenty-one oral history testimonies from the Jewish survivors of the Holocaust collection held at the British library. Around 50,000 Jewish refugees from Central Europe came to Britain in the 1930s after fleeing from Hitler. In addition, a relatively small number of camp survivors and former hidden children settled in the country after the war; the Board of Deputies of British Jews Demographic Unit estimates the figure at 2000...
January 2, 2017: Women's History Review
https://www.readbyqxmd.com/read/28181795/water-responsive-shape-recovery-induced-buckling-in-biodegradable-photo-cross-linked-poly-ethylene-glycol-peg-hydrogel
#4
Abhijit Vijay Salvekar, Wei Min Huang, Rui Xiao, Yee Shan Wong, Subbu S Venkatraman, Kiang Hiong Tay, Ze Xiang Shen
The phenomenon of recovering the permanent shape from a severely deformed temporary shape, but only in the presence of the right stimulus, is known as the shape memory effect (SME). Materials with such an interesting effect are known as shape memory materials (SMMs). Typical stimuli to trigger shape recovery include temperature (heating or cooling), chemical (including water/moisture and pH value), and light. As a SMM is able not only to maintain the temporary shape but also to respond to the right stimulus when it is applied, via shape-shifting, a seamless integration of sensing and actuation functions is achieved within one single piece of material...
February 9, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28177307/acedrg-a-stereochemical-description-generator-for-ligands
#5
Fei Long, Robert A Nicholls, Paul Emsley, Saulius Graǽulis, Andrius Merkys, Antanas Vaitkus, Garib N Murshudov
The program AceDRG is designed for the derivation of stereochemical information about small molecules. It uses local chemical and topological environment-based atom typing to derive and organize bond lengths and angles from a small-molecule database: the Crystallography Open Database (COD). Information about the hybridization states of atoms, whether they belong to small rings (up to seven-membered rings), ring aromaticity and nearest-neighbour information is encoded in the atom types. All atoms from the COD have been classified according to the generated atom types...
February 1, 2017: Acta Crystallographica. Section D, Structural Biology
https://www.readbyqxmd.com/read/28170406/youth-as-contested-sites-of-culture-the-intergenerational-acculturation-gap-amongst-new-migrant-communities-parental-and-young-adult-perspectives
#6
Andre M N Renzaho, Nidhi Dhingra, Nichole Georgeou
BACKGROUND: Immigration often results in changes in family dynamics, and within this process of dynamic relational adjustment youth can be conceptualised as contested sites of culture and associated intergenerational conflicts. This paper considers the experiences of migrant youth in Greater Western Sydney, New South Wales, Australia using conflict as a useful lens through which to view issues of migrant youth identity and their sense of social connectedness, belonging, and agency. The aim of this study was twofold: 1) to explore how migrant youth cope with acculturative stress and intergenerational conflicts, and 2) to better understand the systemic and family-related factors that facilitate positive settlement experiences for migrant youth...
2017: PloS One
https://www.readbyqxmd.com/read/28124783/diversity-of-culturable-bacterial-communities-in-the-intestinal-tracts-of-goldfish-carassius-auratus-and-their-ability-to-produce-n-acyl-homoserine-lactone
#7
Haruo Sugita, Shun Kitao, Satoshi Narisawa, Ryosuke Minamishima, Shiro Itoi
Intestinal bacteria isolated from goldfish (Carassius auratus) were identified based on 16 ribosomal RNA (rRNA) gene sequences and screened for their ability to produce N-acyl homoserine lactone (AHL), an autoinducer of the quorum sensing (QS) system. The 230 aerobes/facultative anaerobes that were isolated comprised members of the genera Aeromonas (184 isolates), Citrobacter (11), Enterobacter (2), Shewanella (28), Vagococcus (1), and Vibrio (4). Among these genera, the two most abundant species were Aeromonas veronii (163 isolates) and Shewanella xiamenensis (27)...
January 26, 2017: Folia Microbiologica
https://www.readbyqxmd.com/read/28124211/youth-from-fundamentalist-societies-what-are-their-attitudes-toward-war-and-peace-and-their-relations-with-anxiety-reactions
#8
Tehila Kalagy, Orna Braun-Lewensohn, Sara Abu-Kaf
The present study was conducted during "Protective Edge," a long-lasting military operation between the State of Israel and Hamas in Gaza, during which hundreds of rockets were fired from Gaza into various regions across the country. At the same time, Israeli forces bombed Gaza and sent in ground forces. The military operation ended after 50 days of fighting, with a cease-fire between the warring sides. The aim of this study was to compare attitudes and perceptions of youth from different religious fundamentalist societies, toward the war and their readiness for peace during this specific violent struggle, and attitudes toward the Israeli-Palestinian (I-P) conflict in general...
January 25, 2017: Journal of Religion and Health
https://www.readbyqxmd.com/read/28122984/parvovirus-expresses-a-small-noncoding-rna-that-plays-an-essential-role-in-virus-replication
#9
Zekun Wang, Weiran Shen, Fang Cheng, Xuefeng Deng, John F Engelhardt, Ziying Yan, Jianming Qiu
: Human bocavirus 1 (HBoV1) belongs to species Primate bocaparvovirus of the genus Bocaparvovirus of the Parvoviridae family. HBoV1 causes acute respiratory tract infections in young children and has a selective tropism for the apical surface of well-differentiated human airway epithelia (HAE). In this study, we identify an additional HBoV1 gene, bocavirus-transcribed small non-coding RNA (BocaSR) within the 3' non-coding region (nt 5199-5338) of the viral genome of positive sense. BocaSR is transcribed by RNA polymerase III (Pol III) from an intragenic promoter at similar levels to that of the capsid protein-coding mRNA and is essential for replication of the viral DNA in both transfected HEK293 and infected HAE cells...
January 25, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28122621/how-does-playing-adapted-sports-affect-quality-of-life-of-people-with-mobility-limitations-results-from-a-mixed-method-sequential-explanatory-study
#10
Félix Côté-Leclerc, Gabrielle Boileau Duchesne, Patrick Bolduc, Amélie Gélinas-Lafrenière, Corinne Santerre, Johanne Desrosiers, Mélanie Levasseur
BACKGROUND: Occupations, including physical activity, are a strong determinant of health. However, mobility limitations can restrict opportunities to perform these occupations, which may affect quality of life. Some people will turn to adapted sports to meet their need to be involved in occupations. Little is known, however, about how participation in adapted sports affects the quality of life of people with mobility limitations. This study thus aimed to explore the influence of adapted sports on quality of life in adult wheelchair users...
January 25, 2017: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/28122532/older-people-s-adherence-to-community-based-group-exercise-programmes-a-multiple-case-study
#11
Clare Killingback, Fotini Tsofliou, Carol Clark
BACKGROUND: Physical inactivity is a global phenomenon, with estimates of one in four adults not being active enough to achieve health benefits, thus heightening the risk of developing non-communicable diseases. In order to realise the health and wellbeing gains associated with physical activity the behaviour must be sustained. Community-based group exercise programmes (CBGEP) utilising social supports have been shown to be one means of not only increasing activity levels for older people, but sustaining physical activity...
January 25, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28118707/kinetic-model-for-the-activation-of-mammalian-olfactory-receptor
#12
Seogjoo Jang, Changbong Hyeon
The sense of smell is triggered by binding of odorants to a set of olfactory receptors (ORs), the activation of which generates specific patterns of neuronal signals in olfactory bulbs. Despite a long history of research and speculations, very little is known about the actual mechanism of OR activation. In particular, there is virtually no theoretical framework capable of describing the kinetics of olfactory activation at a quantitative level. Based on the fact that mammalian ORs belong to a class of G-protein coupled receptors (GPCRs) and utilizing the information available from recent studies on other types of GPCRs with known structural data, we construct a minimal kinetic model for mammalian olfactory activation, obtaining a new expression for the signal strength as a function of odorant and G-protein concentrations and defining this as odor activity (OA)...
February 7, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28112073/creating-community-resilience-through-elder-led-physical-and-social-infrastructure
#13
Daniel P Aldrich, Emi Kyota
OBJECTIVE: Natural disasters and rapidly aging populations are chronic problems for societies worldwide. We investigated the effects of an intervention in Japan known as Ibasho, which embeds elderly residents in vulnerable areas within larger social networks and encourages them to participate in leadership activities. This project sought to deepen the connections of these elderly residents to society and to build elderly leadership and community capacity for future crises. METHODS: We carried out surveys of participants and nonparticipant residents across the city of Ofunato in Tohoku, Japan, 1 year after the intervention began...
January 23, 2017: Disaster Medicine and Public Health Preparedness
https://www.readbyqxmd.com/read/28110517/cultural-safety-and-belonging-for-refugee-background-women-attending-group-pregnancy-care-an-australian-qualitative-study
#14
Elisha Riggs, Sumaiya Muyeen, Stephanie Brown, Wendy Dawson, Pauline Petschel, Waan Tardiff, Fiona Norman, Dannielle Vanpraag, Jo Szwarc, Jane Yelland
BACKGROUND: Refugee women experience higher incidence of childbirth complications and poor pregnancy outcomes. Resettled refugee women often face multiple barriers accessing pregnancy care and navigating health systems in high income countries. METHODS: A community-based model of group pregnancy care for Karen women from Burma was co-designed by health services in consultation with Karen families in Melbourne, Australia. Focus groups were conducted with women who had participated to explore their experiences of using the program, and whether it had helped them feel prepared for childbirth and going home with a new baby...
January 22, 2017: Birth
https://www.readbyqxmd.com/read/28108088/meeting-the-needs-of-sexual-and-gender-minority-youth-formative-research-on-potential-digital-health-interventions
#15
Jessica Steinke, Meredith Root-Bowman, Sherry Estabrook, Deborah S Levine, Leslie M Kantor
PURPOSE: Sexual and gender minority youth (SGMY) have unique risk factors and worse health outcomes than their heterosexual and cisgender counterparts. SGMY's significant online activity represents an opportunity for digital interventions. To help meet the sex education and health needs of SGMY and to understand what they consider important, formative research was conducted to guide and inform the development of new digital health interventions. METHODS: Semistructured interviews, in-person focus groups, and online focus groups were conducted with 92 youths (aged 15-19 years) who self-identify as nonheterosexual, noncisgender, questioning, and/or have engaged in same-sex sexual behavior...
January 11, 2017: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/28102759/antisense-transcription-of-the-myotonic-dystrophy-locus-yields-low-abundant-rnas-with-and-without-cag-n-repeat
#16
Anke E E G Gudde, Simon J van Heeringen, Amanda I de Oude, Ingeborg D G van Kessel, Joseph Estabrook, Eric T Wang, Bé Wieringa, Derick G Wansink
The unstable (CTG·CAG)n trinucleotide repeat in the myotonic dystrophy type 1 (DM1) locus is bidirectionally transcribed from genes with terminal overlap. By transcription in the sense direction, the DMPK gene produces various alternatively spliced mRNAs with a (CUG)n repeat in their 3' UTR. Expression in opposite orientation reportedly yields (CAG)n-repeat containing RNA, but both structure and biological significance of this antisense gene (DM1-AS) are largely unknown. Via a combinatorial approach of computational and experimental analyses of RNA from unaffected individuals and DM1 patients we discovered that DM1-AS spans >6 kb, contains alternative transcription start sites and uses alternative polyadenylation sites up- and downstream of the (CAG)n repeat...
January 19, 2017: RNA Biology
https://www.readbyqxmd.com/read/28093796/the-role-of-perceived-burden-and-social-support-in-suicide-and-depression
#17
Christopher M Bell, Josephine A Ridley, James C Overholser, Kevin Young, Alison Athey, Jennifer Lehmann, Kristie Phillips
In a sample of 114 military veterans with depression histories, perceived burden was related to depression symptoms and suicide attempt history. After accounting for perceived burden, sense of belonging was negatively related to depression. Among the areas of social support, family support was inversely related to both depression and suicide history. After accounting for family support, personal meaning from relationships and friend support were related to depression. The results of this study suggest that perceived burdensomeness may be a stronger determinant of suicidality than sense of belonging or social support...
January 17, 2017: Suicide & Life-threatening Behavior
https://www.readbyqxmd.com/read/28077849/emigration-from-within
#18
Judit Szekacs-Weisz
Listening to the stories of people belonging to different generations in motion-both in our consulting rooms and our personal lives-served as introductory lectures into the fundamental aspects of changing context. Through these rich and diverse stories, one enters a territory which is not only multilingual but multidimensional: defined and shaped by historical, political, economic and socio-cultural transformations. Giving voice to these silent stories proved helpful for us when going behind walls that traditional analysis could not always penetrate, partly because, in many cases, analysts and analysands have been struggling with the same untouchable issues...
December 2016: American Journal of Psychoanalysis
https://www.readbyqxmd.com/read/28067833/contribution-of-the-rgfd-quorum-sensing-peptide-to-rgf-regulation-and-host-cell-association-in-group-b-streptococcus
#19
Robert E Parker, David Knupp, Rim Al Safadi, Agnѐs Rosenau, Shannon D Manning
Streptococcus agalactiae (group B Streptococcus; GBS) is a common inhabitant of the genitourinary and/or gastrointestinal tract in up to 40% of healthy adults; however, this opportunistic pathogen is able to breach restrictive host barriers to cause disease and persist in harsh and changing conditions. This study sought to identify a role for quorum sensing, a form of cell to cell communication, in the regulation of the fibrinogen-binding (rgfBDAC) two-component system and the ability to associate with decidualized endometrial cells in vitro...
January 6, 2017: Genes
https://www.readbyqxmd.com/read/28056742/fungal-biofilm-a-real-obstacle-against-an-efficient-therapy-lessons-from-candida
#20
Thaís Pereira de Mello, Lívia de Souza Ramos, Lys Adriana Braga-Silva, Marta Helena Branquinha, André Luis Souza Dos Santos
The past decades have witnessed a dramatic increase in invasive fungal infections, especially caused by different species belonging to the Candida genus. Nowadays, even after many improvements in several medical procedures, Candida infections (candidiasis) still account for an unacceptable high rate of morbimortality in hospital settings. Corroborating this statement, fungal biofilms formed on both abiotic and living surfaces are responsible for an important medical and economic burden, since biofilm lifestyle confers numerous advantages to the pathogens, including high tolerance to environmental stresses such as antimicrobials and host immune responses...
January 5, 2017: Current Topics in Medicinal Chemistry
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