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https://www.readbyqxmd.com/read/28922826/the-burnley-dog-war-the-politics-of-dog-walking-and-the-battle-over-public-parks-in-post-industrial-britain
#1
Neil Pemberton
This article investigates controversies surrounding dog walking and dog fouling in 1970s and early 1980s Britain, focusing on the microhistory of a series of events in a Lancashire mill town that became known as the 'Burnley Dog War.' A ban on dog walkers from Burnley's main public parks triggered a highly publicised seven-year struggle over access. On one level, the park ban served as a rallying cry for dog lovers across Britain, widening the dividing line between dog owners and dog haters. On another level, it constituted a struggle between antagonists over questions of belonging and exclusion in a town devastated by large-scale deindustrialisation...
June 1, 2017: 20 Century British History
https://www.readbyqxmd.com/read/28920855/pfma-a-novel-quorum-quenching-n-acylhomoserine-lactone-acylase-from-pseudoalteromonas-flavipulchra
#2
Na Liu, Min Yu, Youbin Zhao, Jingguang Cheng, Ke An, Xiao-Hua Zhang
Many bacteria, such as Proteobacteria, Cyanobacteria and Bacteroidetes, use N-acylhomoserine lactones (AHLs) as quorum-sensing (QS) signal molecules for communication. Enzymatic degradation of AHLs, such as AHL acylase and AHL lactonase, can degrade AHLs (quorum quenching, QQ) to attenuate or disarm the virulence of pathogens. QQ is confirmed to be common in marine bacterial communities. Many genes encoding AHL acylases are found in marine bacteria and metagenomic collections, but only a few of these have been characterized in detail...
September 18, 2017: Microbiology
https://www.readbyqxmd.com/read/28917654/the-anticancer-functions-of-rig-i-like-receptors-rig-i-and-mda5-and-their-applications-in-cancer-therapy
#3
REVIEW
Yuanbing Wu, Xinqiang Wu, Longhuo Wu, Xiangcai Wang, Zhiping Liu
Cancer is a major cause of death worldwide, and its incidence and mortality continuously increase in China. Nowadays, cancer heavily influences our health and constitutes enormous burden on society and families. Although there are many tools for cancer treatment, but the overall therapeutic effect is poor. In addition, cancer cells often develop resistance to therapy due to defective cell death or immune escape mechanisms. Therefore, it is a promising way for cancer treatment to effectively activate apoptosis and conquer immunosuppression...
August 31, 2017: Translational Research: the Journal of Laboratory and Clinical Medicine
https://www.readbyqxmd.com/read/28914145/did-you-reject-me-for-someone-else-rejections-that-are-comparative-feel-worse
#4
Sebastian Deri, Emily M Zitek
Rejections differ. For those who are rejected, one important difference is whether they are rejected for someone else (comparative rejection) or no one at all (noncomparative rejection). We examined the effect of this distinction on emotional reactions to a rejection in four studies ( N = 608), one of which was fully preregistered. Our results show that comparative rejections feel worse than noncomparative rejections and that this may be because such rejections lead to an increased sense of exclusion and decreased belonging...
August 1, 2017: Personality & Social Psychology Bulletin
https://www.readbyqxmd.com/read/28913358/central-modulation-of-neuroinflammation-by-neuropeptides-and-energy-sensing-hormones-during-obesity
#5
REVIEW
Roger Maldonado-Ruiz, Lizeth Fuentes-Mera, Alberto Camacho
Central nervous system (CNS) senses energy homeostasis by integrating both peripheral and autonomic signals and responding to them by neurotransmitters and neuropeptides release. Although it is previously considered an immunologically privileged organ, we now know that this is not so. Cells belonging to the immune system, such as B and T lymphocytes, can be recruited into the CNS to face damage or infection, in addition to possessing resident immunological cells, called microglia. In this way, positive energy balance during obesity promotes an inflammatory state in the CNS...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28912619/what-moral-character-is-and-is-not
#6
Marie I George
Louise Mitchell discusses character in "Integrity and virtue: The forming of good character" (The Linacre Quarterly 82, no. 2: 149-169). I argue that she is mistaken in identifying character as a potency and that it is rather the sum of one's moral habits and dispositions. I establish this by showing that if one correctly applies the division Aristotle presents in the text that Mitchell relies on, it follows that character belongs in the category of habit. I further support this conclusion by considering how people commonly speak of moral character...
August 2017: Linacre Quarterly
https://www.readbyqxmd.com/read/28912317/complete-genome-sequence-of-nervous-necrosis-virus-isolated-from-orange-spotted-grouper-epinephelus-coioides-in-taiwan
#7
Ming-Hui Chien, Thi Tuyet Minh Vo, Shaw-Yun Wu, Cheng-Hui Lin
The genome sequence of nervous necrosis virus strain KS1 isolated from orange-spotted grouper (Epinephelus coioides) was cloned and analyzed. The viral genome is composed of two single-stranded positive-sense RNA molecules, RNA1 and RNA2. Phylogenetic analysis shows that the virus strain KS1 belongs to the red-spotted grouper nervous necrosis virus genotype.
September 14, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28911115/the-ires5-utr-of-the-dicistrovirus-cricket-paralysis-virus-is-a-type-iii-ires-containing-an-essential-pseudoknot-structure
#8
Lauriane Gross, Quentin Vicens, Evelyne Einhorn, Audrey Noireterre, Laure Schaeffer, Lauriane Kuhn, Jean-Luc Imler, Gilbert Eriani, Carine Meignin, Franck Martin
Cricket paralysis virus (CrPV) is a dicistrovirus. Its positive-sense single-stranded RNA genome contains two internal ribosomal entry sites (IRESs). The 5' untranslated region (5'UTR) IRES5'UTR mediates translation of non-structural proteins encoded by ORF1 whereas the well-known intergenic region (IGR) IRESIGR is required for translation of structural proteins from open reading frame 2 in the late phase of infection. Concerted action of both IRES is essential for host translation shut-off and viral translation...
September 6, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28903661/social-identification-in-sports-teams-the-role-of-personal-social-and-collective-identity-motives
#9
William E Thomas, Rupert Brown, Matthew J Easterbrook, Vivian L Vignoles, Claudia Manzi, Chiara D'Angelo, Jeremy J Holt
Based on motivated identity construction theory (MICT; Vignoles, 2011), we offer an integrative approach examining the combined roles of six identity motives (self-esteem, distinctiveness, belonging, meaning, continuity, and efficacy) instantiated at three different motivational levels (personal, social, and collective identity) as predictors of group identification. These identity processes were investigated among 369 members of 45 sports teams from England and Italy in a longitudinal study over 6 months with four time points...
April 2017: Personality & Social Psychology Bulletin
https://www.readbyqxmd.com/read/28902403/s-nitrosylation-denitrosylation-as-a-regulatory-mechanism-of-salt-stress-sensing-in-sunflower-seedlings
#10
Prachi Jain, Christine von Toerne, Christian Lindermayr, Satish C Bhatla
Nitric oxide (NO) and various reactive nitrogen species (RNS) produced in cells in normal growth conditions and their enhanced production under stress conditions, are responsible for a variety of biochemical aberrations. Present findings demonstrate that sunflower seedling roots exhibit high sensitivity to salt stress in terms of nitrite accumulation. A significant reduction in S-nitrosoglutathione reductase (GSNOR) activity is evident in response to salt stress. Restoration of GSNOR activity with dithioerythritol (DTT) shows that the enzyme is reversibly inhibited under conditions of 120 mM NaCl...
September 13, 2017: Physiologia Plantarum
https://www.readbyqxmd.com/read/28893098/chemical-sensing-of-benzo-a-pyrene-using-corchorus-depressus-fluorescent-flavonoids
#11
Wajiha Ahmad, Nosheen Fatima Rana, Sundus Riaz, Nasir Mehmood Ahmad, Maryam Hameed, Ayesha Naeem, Rabbiya Tahir
Plant phytochemicals, such as flavonoids are in use for the development of optical biosensor. Benzo[a]pyrene (B[a]P), is a pervasive environmental and dietary carcinogen. A fluorescent assay is developed using plant isolated flavonoid for the detection of B[a]P. High content saponins are excluded from the flavonoid-containing methanolic extract of Corchorus depressus by implying reduction of silver ions by saponins resulting in formation of silver nanoparticles. Isolated plant flavonoids are used to develop a spectrofluorometric assay for the detection of B[a]P...
September 11, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28890583/compassionate-goals-and-affect-in-social-situations
#12
Amy Canevello, Jennifer Crocker
Optimal social interactions can leave people feeling socially connected and at ease, which has clear implications for health and psychological well-being. Yet, not all social interactions leave people feelings at ease and connected. What explains this variability? We draw from the egosystem-ecosystem theory of social motivation (Crocker & Canevello, 2008) to suggest that compassionate goals to support others explain some of this variability. We explored the nature of this association across 4 studies and varying social contexts...
April 2017: Motivation and Emotion
https://www.readbyqxmd.com/read/28890241/manual-and-expert-annotation-of-the-nearly-complete-genome-sequence-of-staphylococcus-sciuri-strain-atcc-29059-a-reference-for-the-oxidase-positive-staphylococci-that-supports-the-atypical-phenotypic-features-of-the-species-group
#13
Eugene Christo-Foroux, Tatiana Vallaeys, Valentin Loux, Elie Dassa, Josef Deutscher, Cécile Wandersman, Aurélien Livernois, Chloe Hot, Alexis Criscuolo, Catherine Dauga, Dominique Clermont, Olivier Chesneau
Staphylococcus sciuri is considered to be one of the most ancestral species in the natural history of the Staphylococcus genus that consists of 48 validly described species. It belongs to the basal group of oxidase-positive and novobiocin-resistant staphylococci that diverged from macrococci approximately 250 million years ago. Contrary to other groups, the S. sciuri species group has not developed host-specific colonization strategies. Genome analysis of S. sciuri ATCC 29059 provides here the first genetic basis for atypical traits that would support the switch between the free-living style and the infective state in animals and humans...
August 24, 2017: Systematic and Applied Microbiology
https://www.readbyqxmd.com/read/28881163/exploiting-poly-i-c-to-induce-cancer-cell-apoptosis
#14
Francesca Bianchi, Samantha Pretto, Elda Tagliabue, Andrea Balsari, Lucia Sfondrini
TLR3 belong to the Toll-like receptors family, it is mainly expressed on immune cells where it senses pathogen-associated molecular patterns and initiates innate immune response. TLR3 agonist poly(I:C) was developed to mimic pathogens infection and boost immune system activation to promote anti-cancer therapy. Accordingly, TLR agonists were included in the National Cancer Institute list of immunotherapeutic agents with the highest potential to cure cancer. Besides well known effects on immune cells, poly(I:C) was also shown, in experimental models, to directly induce apoptosis in cancer cells expressing TLR3...
September 7, 2017: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/28876981/genetic-and-structural-analyses-of-rrnpp-intercellular-peptide-signaling-of-gram-positive-bacteria
#15
Matthew B Neiditch, Glenn C Capodagli, Gerd Prehna, Michael J Federle
Bacteria use diffusible chemical messengers, termed pheromones, to coordinate gene expression and behavior among cells in a community by a process known as quorum sensing. Pheromones of many gram-positive bac, such as Bacillus and Streptococcus, are small, linear peptides secreted from cells and subsequently detected by sensory receptors such as those belonging to the large family ofRRNPP proteins. These proteins are cytoplasmic pheromone receptors sharing a structurally similar pheromone-binding domain that functions allosterically to regulate receptor activity...
September 6, 2017: Annual Review of Genetics
https://www.readbyqxmd.com/read/28870195/a-qualitative-study-of-filipina-immigrants-stress-distress-and-coping-the-impact-of-their-multiple-transnational-roles-as-women
#16
Melanie L Straiton, Heloise Marie L Ledesma, Tam T Donnelly
BACKGROUND: Migration is associated with a number of stress factors which can affect mental health. Ethnicity, gender and socioeconomic status can intertwine with and influence the process of migration and mental health. Philippine migration to Europe has increased in recent years and has become more feminised. Knowing more about the factors that influence immigrants' mental health and coping can help aid health care delivery and policy planning. The purpose of this qualitative study was to explore the contextual factors that influence the mental health of Filipinas living in Norway and their coping strategies...
September 5, 2017: BMC Women's Health
https://www.readbyqxmd.com/read/28864097/validating-the-11-item-revised-university-of-california-los-angeles-scale-to-assess-loneliness-among-older-adults-an-evaluation-of-factor-structure-and-other-measurement-properties
#17
Joonyup Lee, John G Cagle
OBJECTIVE: To examine the measurement properties and factor structure of the short version of the Revised University of California Los Angeles (R-UCLA) loneliness scale from the Health and Retirement Study (HRS). METHODS: Based on data from 3,706 HRS participants aged 65 + who completed the 2012 wave of the HRS and its Psychosocial Supplement, the measurement properties and factorability of the R-UCLA were examined by conducting an exploratory factor analysis (EFA) and the confirmatory factor analysis (CFA) on randomly split halves...
June 29, 2017: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28862079/sense-of-community-organizational-commitment-and-quality-of-services
#18
Mai-Stiina Lampinen, ElinaAnnikki Suutala, Anne Irmeli Konu
Purpose The purpose of this paper is to examine how factors associated with a sense of community in the workplace are connected with organizational commitment and the quality of services among frontline managers and middle managers in social and health care services in Finland. Design/methodology/approach A questionnaire designed specifically for this research was sent to 241 lower-level and middle-level managers in social and health care services in central Finland. A total of 136 managers completed the questionnaire (response rate 56 per cent)...
September 1, 2017: Leadership in Health Services
https://www.readbyqxmd.com/read/28861465/incorporating-explicit-geospatial-data-shows-more-species-at-risk-of-extinction-than-the-current-red-list
#19
Natalia Ocampo-Peñuela, Clinton N Jenkins, Varsha Vijay, Binbin V Li, Stuart L Pimm
The IUCN (International Union for Conservation of Nature) Red List classifies species according to their risk of extinction, informing global to local conservation decisions. Unfortunately, important geospatial data do not explicitly or efficiently enter this process. Rapid growth in the availability of remotely sensed observations provides fine-scale data on elevation and increasingly sophisticated characterizations of land cover and its changes. These data readily show that species are likely not present within many areas within the overall envelopes of their distributions...
November 2016: Science Advances
https://www.readbyqxmd.com/read/28859838/far-from-the-lonely-crowd-the-trenchant-techno-cynicism-of-mr-robot
#20
REVIEW
Daniel Volmar
Mr. Robot is a television drama with an unusually techno-cynical premise, tying cybersecurity to the contemporary malaise of social alienation and political disengagement. Weary of consumer capitalism, the show's youthful protagonists seek a more authentic sense of belonging by exploiting the vulnerability of a global economic system that depends critically on creaking technological infrastructures. A remarkable display of iconoclasm for commercial entertainment, Mr. Robot suggests rising discontentment with the commodification of friendship through consumer electronics, but it may also offer media enterprises a model for how to profit from that discontentment in the future...
August 28, 2017: Endeavour
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