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https://www.readbyqxmd.com/read/28102759/antisense-transcription-of-the-myotonic-dystrophy-locus-yields-low-abundant-rnas-with-and-without-cag-n-repeat
#1
Anke E E G Gudde, Simon J van Heeringen, Amanda I de Oude, Ingeborg D G van Kessel, Joseph Estabrook, Eric T Wang, Bé Wieringa, Derick G Wansink
The unstable (CTG·CAG)n trinucleotide repeat in the myotonic dystrophy type 1 (DM1) locus is bidirectionally transcribed from genes with terminal overlap. By transcription in the sense direction, the DMPK gene produces various alternatively spliced mRNAs with a (CUG)n repeat in their 3' UTR. Expression in opposite orientation reportedly yields (CAG)n-repeat containing RNA, but both structure and biological significance of this antisense gene (DM1-AS) are largely unknown. Via a combinatorial approach of computational and experimental analyses of RNA from unaffected individuals and DM1 patients we discovered that DM1-AS spans >6 kb, contains alternative transcription start sites and uses alternative polyadenylation sites up- and downstream of the (CAG)n repeat...
January 19, 2017: RNA Biology
https://www.readbyqxmd.com/read/28093796/the-role-of-perceived-burden-and-social-support-in-suicide-and-depression
#2
Christopher M Bell, Josephine A Ridley, James C Overholser, Kevin Young, Alison Athey, Jennifer Lehmann, Kristie Phillips
In a sample of 114 military veterans with depression histories, perceived burden was related to depression symptoms and suicide attempt history. After accounting for perceived burden, sense of belonging was negatively related to depression. Among the areas of social support, family support was inversely related to both depression and suicide history. After accounting for family support, personal meaning from relationships and friend support were related to depression. The results of this study suggest that perceived burdensomeness may be a stronger determinant of suicidality than sense of belonging or social support...
January 17, 2017: Suicide & Life-threatening Behavior
https://www.readbyqxmd.com/read/28077849/emigration-from-within
#3
Judit Szekacs-Weisz
Listening to the stories of people belonging to different generations in motion-both in our consulting rooms and our personal lives-served as introductory lectures into the fundamental aspects of changing context. Through these rich and diverse stories, one enters a territory which is not only multilingual but multidimensional: defined and shaped by historical, political, economic and socio-cultural transformations. Giving voice to these silent stories proved helpful for us when going behind walls that traditional analysis could not always penetrate, partly because, in many cases, analysts and analysands have been struggling with the same untouchable issues...
December 2016: American Journal of Psychoanalysis
https://www.readbyqxmd.com/read/28067833/contribution-of-the-rgfd-quorum-sensing-peptide-to-rgf-regulation-and-host-cell-association-in-group-b-streptococcus
#4
Robert E Parker, David Knupp, Rim Al Safadi, Agnѐs Rosenau, Shannon D Manning
Streptococcus agalactiae (group B Streptococcus; GBS) is a common inhabitant of the genitourinary and/or gastrointestinal tract in up to 40% of healthy adults; however, this opportunistic pathogen is able to breach restrictive host barriers to cause disease and persist in harsh and changing conditions. This study sought to identify a role for quorum sensing, a form of cell to cell communication, in the regulation of the fibrinogen-binding (rgfBDAC) two-component system and the ability to associate with decidualized endometrial cells in vitro...
January 6, 2017: Genes
https://www.readbyqxmd.com/read/28056742/fungal-biofilm-a-real-obstacle-against-an-efficient-therapy-lessons-from-candida
#5
Thaís Pereira de Mello, Lívia de Souza Ramos, Lys Adriana Braga-Silva, Marta Helena Branquinha, André Luis Souza Dos Santos
The past decades have witnessed a dramatic increase in invasive fungal infections, especially caused by different species belonging to the Candida genus. Nowadays, even after many improvements in several medical procedures, Candida infections (candidiasis) still account for an unacceptable high rate of morbimortality in hospital settings. Corroborating this statement, fungal biofilms formed on both abiotic and living surfaces are responsible for an important medical and economic burden, since biofilm lifestyle confers numerous advantages to the pathogens, including high tolerance to environmental stresses such as antimicrobials and host immune responses...
January 5, 2017: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/28049679/dental-students-perceptions-of-learning-value-in-pbl-groups-with-medical-and-dental-students-together-versus-dental-students-alone
#6
Maryam Amin, Rosslynn Zulla, Gisele Gaudet-Amigo, Steven Patterson, Natalie Murphy, Shelley Ross
At a dental school in Canada, problem-based learning (PBL) sessions were restructured from an integrated dental-medical model to a separate dental model, resulting in three groups of students available for study: those who had participated in the two-year dental and medical combined, the one-year dental and medical combined, the one-year dental alone, and the two-year dental alone. The aim of this qualitative study was to examine the extent to which the PBL structure affected the dental students' perceptions of the learning value of PBL in the different models...
January 2017: Journal of Dental Education
https://www.readbyqxmd.com/read/28042195/improving-the-school-context-of-early-adolescence-through-teacher-attunement-to-victimization-effects-on-school-belonging
#7
Kate E Norwalk, Jill V Hamm, Thomas W Farmer, Kathryn Barnes
The present study examined the effects of teacher attunement to victimization on student perceptions of the bullying culture of their schools as a means of fostering a sense of belonging among early adolescents. Participants (n = 1,264) in sixth grade reported on the frequency that they had been bullied, and teachers were asked to report students who were "picked on." Teacher attunement represented the correspondence between self-identified and teacher-identified victims. Attunement at the beginning of the school year was related to positive changes in student reports that their peers would intervene in bullying; in turn, sense of belonging was greater when students perceived that their peers would intervene in bullying...
October 2016: Journal of Early Adolescence
https://www.readbyqxmd.com/read/28041960/structure-s-function-s-and-inhibition-of-the-rna-dependent-rna-polymerase-of-noroviruses
#8
REVIEW
Jerome Deval, Zhinan Jin, Ying-Chih Chuang, C Cheng Kao
Noroviruses belong to the Caliciviridae family of single-stranded positive-sense RNA viruses. The genus Norovirus includes seven genogroups (designated GI-GVII), of which GI, GII and GIV infect humans. Human noroviruses are responsible for widespread outbreaks of acute gastroenteritis and represent one of the most common causes of foodborne illness. No vaccine or antiviral treatment options are available for norovirus infection. The RNA-dependent RNA polymerase (RdRp) of noroviruses is a key enzyme responsible for transcription and replication of the viral genome...
December 29, 2016: Virus Research
https://www.readbyqxmd.com/read/28032926/soft-actuators-for-small-scale-robotics
#9
Lindsey Hines, Kirstin Petersen, Guo Zhan Lum, Metin Sitti
This review comprises a detailed survey of ongoing methodologies for soft actuators, highlighting approaches suitable for nanometer- to centimeter-scale robotic applications. Soft robots present a special design challenge in that their actuation and sensing mechanisms are often highly integrated with the robot body and overall functionality. When less than a centimeter, they belong to an even more special subcategory of robots or devices, in that they often lack on-board power, sensing, computation, and control...
December 29, 2016: Advanced Materials
https://www.readbyqxmd.com/read/28029348/ethnic-identity-and-paranoid-thinking-implicit-out-group-preference-and-language-dominance-predict-paranoia-in-emirati-women
#10
Justin Thomas, Richard P Bentall, Lowri Hadden, Lily O'Hara
BACKGROUND AND OBJECTIVES: Psychotic experiences including persecutory beliefs are elevated among immigrant and minority populations, especially when living in low ethnic density neighbourhoods (the ethnic density effect). Discrimination, victimization and experiencing a sense of 'not belonging' are hypothesized to play a role in this effect. Because a secure ethnic identity protects against poor self-esteem it may also protect against paranoia. This study explores the relationship between language proficiency (Arabic/English), in-group identity (implicit and explicit) and paranoia in female Emirati university students...
October 24, 2016: Journal of Behavior Therapy and Experimental Psychiatry
https://www.readbyqxmd.com/read/28028740/impact-of-ethnic-composition-on-mechanisms-of-change-in-school-based-substance-use-intervention-groups
#11
Guadalupe A Bacio, Kristin L Tomlinson, Tracey A Garcia, Kristen G Anderson, Mark G Myers, Sandra A Brown
Delivering alcohol use intervention services in the school setting represents a key approach to engaging youth of all backgrounds, particularly underserved populations, in such programming. Relative progress has been made toward implementing culturally responsive services for youth; however, little is known about the role of ethnic composition on group processes purported to underlie mechanisms of change. We examined associations between ethnic group composition and therapeutic processes within a voluntary, school-based alcohol use intervention at seven schools across three cities (N groups = 353)...
December 27, 2016: Prevention Science: the Official Journal of the Society for Prevention Research
https://www.readbyqxmd.com/read/28025917/science-as-national-belonging-the-construction-of-svalbard-as-a-norwegian-space
#12
Peder Roberts, Eric Paglia
This article examines how science has been employed to establish, maintain, and contest senses of belonging on Svalbard, an Arctic archipelago administered by Norway since 1925 under an international treaty. Our central argument is that the process of constructing Svalbard as a space belonging to Norway has long been intertwined with the processes of describing and representing the archipelago and that participating in those processes has also permitted other states to articulate their own narratives of belonging - on Svalbard in particular and in the Arctic more generally...
December 2016: Social Studies of Science
https://www.readbyqxmd.com/read/28018377/an-lrr-malectin-receptor-like-kinase-mediates-resistance-to-non-adapted-and-adapted-powdery-mildew-fungi-in-barley-and-wheat
#13
Jeyaraman Rajaraman, Dimitar Douchkov, Götz Hensel, Francesca L Stefanato, Anna Gordon, Nelzo Ereful, Octav F Caldararu, Andrei-Jose Petrescu, Jochen Kumlehn, Lesley A Boyd, Patrick Schweizer
Pattern recognition receptors (PRRs) belonging to the multigene family of receptor-like kinases (RLKs) are the sensing devices of plants for microbe- or pathogen-associated molecular patterns released from microbial organisms. Here we describe Rnr8 (for Required for non-host resistance 8) encoding HvLEMK1, a LRR-malectin domain-containing transmembrane RLK that mediates non-host resistance of barley to the non-adapted wheat powdery mildew fungus Blumeria graminis f.sp. tritici. Transgenic barley lines with silenced HvLEMK1 allow entry and colony growth of the non-adapted pathogen, although sporulation was reduced and final colony size did not reach that of the adapted barley powdery mildew fungus B...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28018263/honor-as-cultural-mindset-activated-honor-mindset-affects-subsequent-judgment-and-attention-in-mindset-congruent-ways
#14
Sheida Novin, Daphna Oyserman
Honor values articulate gender roles, the importance of reputation in maintaining one's place in society, and maintaining respect for the groups one belongs to. In that sense honor provides a template for organizing social interactions and hence may be functional even among people and societies that do not report valuing and endorsing honor. We test the prediction that honor influences judgment and attention when activated in two experiments (N = 538). Using a culture-as-situated cognition perspective, we predicted that activating one aspect of honor would activate other aspects, even among individuals who do not much endorse honor values...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/28012191/neither-foolish-nor-finished-identity-control-among-older-adults-with-hiv-in-rural-malawi
#15
Emily Freeman
Prevalence of HIV after age 50 is considerable, especially in southern Africa. Negative social constructions of HIV in older age, and the health consequences of ageing with the virus, mean that having HIV presents a challenge for many people's roles and social memberships, threatening to disrupt their sense of self. Using constructivist grounded theory and qualitative data from rural Malawi, this paper describes how older men and women deal with these identity challenges. Drawing on a symbolic interactionist framework, it uses identity control theory to explore how the study's participants presented their post-diagnosis behaviours in ways that maintained their most significant pre-diagnosis identities as 'adults', a label they gave to the core identity of being a person who belongs in the social world...
December 24, 2016: Sociology of Health & Illness
https://www.readbyqxmd.com/read/28008695/family-members-experience-of-intensive-care-unit-support-group-qualitative-analysis-of-intervention
#16
Dvora Kirshbaum-Moriah, Chaya Harel, Julie Benbenishty
BACKGROUND: Family members of intensive care unit patients develop anxiety, depression and/or symptoms suggestive of risk for post-traumatic stress. Nurse-led support groups have been recommended and used in a variety of settings as a mechanism to help meet family needs and overcome challenges. These groups have been reported to increase the members' understanding of complex medical issues involved in their situations and to be helpful in identifying practical coping mechanisms. AIM: To investigate the experiences of family members participating in a nurse-social worker led support group in the intensive care unit...
December 22, 2016: Nursing in Critical Care
https://www.readbyqxmd.com/read/28008474/making-sense-of-metacommunities-dispelling-the-mythology-of-a-metacommunity-typology
#17
REVIEW
Bryan L Brown, Eric R Sokol, James Skelton, Brett Tornwall
Metacommunity ecology has rapidly become a dominant framework through which ecologists understand the natural world. Unfortunately, persistent misunderstandings regarding metacommunity theory and the methods for evaluating hypotheses based on the theory are common in the ecological literature. Since its beginnings, four major paradigms-species sorting, mass effects, neutrality, and patch dynamics-have been associated with metacommunity ecology. The Big 4 have been misconstrued to represent the complete set of metacommunity dynamics...
December 22, 2016: Oecologia
https://www.readbyqxmd.com/read/28006002/unbiased-rna-shotgun-metagenomics-in-social-and-solitary-wild-bees-detects-associations-with-eukaryote-parasites-and-new-viruses
#18
Karel Schoonvaere, Lina De Smet, Guy Smagghe, Andy Vierstraete, Bart P Braeckman, Dirk C de Graaf
The diversity of eukaryote organisms and viruses associated with wild bees remains poorly characterized in contrast to the well-documented pathosphere of the western honey bee, Apis mellifera. Using a deliberate RNA shotgun metagenomic sequencing strategy in combination with a dedicated bioinformatics workflow, we identified the (micro-)organisms and viruses associated with two bumble bee hosts, Bombus terrestris and Bombus pascuorum, and two solitary bee hosts, Osmia cornuta and Andrena vaga. Ion Torrent semiconductor sequencing generated approximately 3...
2016: PloS One
https://www.readbyqxmd.com/read/28000333/leveraging-social-capital-of-individuals-with-intellectual-disabilities-through-participation-on-facebook
#19
Carmit-Noa Shpigelman
BACKGROUND: Participation in social networking sites has considerable potential to leverage the individual's social capital, including persons with intellectual disabilities, whose real-world social networks are fairly limited. METHOD: This study aimed to understand how individuals with intellectual disabilities use Facebook to access social capital benefits, if at all. Qualitative interviews and observations were conducted with 20 adult Facebook users with intellectual disabilities...
December 21, 2016: Journal of Applied Research in Intellectual Disabilities: JARID
https://www.readbyqxmd.com/read/27994147/ownership-of-an-artificial-limb-induced-by-electrical-brain-stimulation
#20
Kelly L Collins, Arvid Guterstam, Jeneva Cronin, Jared D Olson, H Henrik Ehrsson, Jeffrey G Ojemann
Replacing the function of a missing or paralyzed limb with a prosthetic device that acts and feels like one's own limb is a major goal in applied neuroscience. Recent studies in nonhuman primates have shown that motor control and sensory feedback can be achieved by connecting sensors in a robotic arm to electrodes implanted in the brain. However, it remains unknown whether electrical brain stimulation can be used to create a sense of ownership of an artificial limb. In this study on two human subjects, we show that ownership of an artificial hand can be induced via the electrical stimulation of the hand section of the somatosensory (SI) cortex in synchrony with touches applied to a rubber hand...
January 3, 2017: Proceedings of the National Academy of Sciences of the United States of America
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