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https://www.readbyqxmd.com/read/28449031/rnablueprint-flexible-multiple-target-nucleic-acid-sequence-design
#1
Stefan Hammer, Birgit Tschiatschek, Christoph Flamm, Ivo L Hofacker, Sven Findeiß
Motivation: Realizing the value of synthetic biology in biotechnology and medicine requires the design of molecules with specialized functions. Due to its close structure to function relationship, and the availability of good structure prediction methods and energy models, RNA is perfectly suited to be synthetically engineered with predefined properties. However, currently available RNA design tools cannot be easily adapted to accommodate new design specifications. Furthermore, complicated sampling and optimization methods are often developed to suit a specific RNA design goal, adding to their inflexibility...
April 25, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28448235/intracranial-artery-steno-occlusion-diagnosis-by-using-three-dimensional-parallel-multichannel-transmission-mr-imaging
#2
Mi Sun Chung, Seung Chai Jung, Seon-Ok Kim, Ho Sung Kim, Choong Gon Choi, Sang Joon Kim, Sun U Kwon, Dong-Wha Kang, Jong S Kim
Purpose To determine whether magnetic resonance (MR) imaging by using two-dimensional spatially selective radiofrequency (RF) excitation pulses (zoomed MR imaging) is a reliable method for the diagnosis of intracranial artery steno-occlusion compared with full-field-of-view (FOV) MR imaging. Materials and Methods The institutional review board approved this retrospective study and informed consent was waived. From December 2014 to August 2015, 88 patients who underwent both full-FOV MR imaging and zoomed MR imaging for further evaluation of intracranial artery steno-occlusion at prior luminal evaluation were included...
April 27, 2017: Radiology
https://www.readbyqxmd.com/read/28448225/online-positive-thinking-training-intervention-for-caregivers-of-individuals-with-asd-necessity-acceptability-and-feasibility
#3
Abir K Bekhet
BACKGROUND: More than 3.5 million people in the United States are diagnosed with autism spectrum disorder (ASD). Caring for children with ASD can be stressful and can be detrimental to the well-being of the caregivers (CGs). However, the adverse effects of caregiving on the well-being of CGs may be avoided with appropriate interventions. CGs of persons with ASD might benefit from a positive thinking training (PTT) intervention to help them cope with the stress of caregiving. However, the necessity, acceptability and feasibility for PTT in ASD CGs have not been studied...
May 2017: Issues in Mental Health Nursing
https://www.readbyqxmd.com/read/28447848/spatial-biases-in-motion-extrapolation-for-manual-interception
#4
Sinéad A Reid, Joost C Dessing
The exact mechanisms by which humans control the manual interception of moving targets are currently unknown. Here, the authors explored the behaviors associated with the spatial control for manual interception. The examined task required controlling a cursor to intercept moving targets on a touch screen. They explored the effects of target motion direction, curvature and occlusion on manual interception. They observed occlusion-dependent spatial errors and arrival times for curved and diagonal trajectories (larger errors and earlier arrival of the finger at its final position with longer occlusion)...
April 27, 2017: Journal of Experimental Psychology. Human Perception and Performance
https://www.readbyqxmd.com/read/28447835/it-doesn-t-hurt-to-ask-question-asking-increases-liking
#5
Karen Huang, Michael Yeomans, Alison Wood Brooks, Julia Minson, Francesca Gino
Conversation is a fundamental human experience that is necessary to pursue intrapersonal and interpersonal goals across myriad contexts, relationships, and modes of communication. In the current research, we isolate the role of an understudied conversational behavior: question-asking. Across 3 studies of live dyadic conversations, we identify a robust and consistent relationship between question-asking and liking: people who ask more questions, particularly follow-up questions, are better liked by their conversation partners...
April 27, 2017: Journal of Personality and Social Psychology
https://www.readbyqxmd.com/read/28447820/are-peer-specialists-happy-on-the-job
#6
Sarah Jenkins, Tiffany Chenneville, Christina Salnaitis
OBJECTIVE: This study was designed to examine the impact of role clarity and job training on job satisfaction among peer specialists. METHOD: A 3-part survey assessing job training, job satisfaction, and role clarity was administered online to 195 peer specialists who are members of the International Association of Peer Specialists. Data was analyzed using descriptive statistics, correlational analyses to include multiple linear regressions and analysis of variance...
April 27, 2017: Psychiatric Rehabilitation Journal
https://www.readbyqxmd.com/read/28447806/blame-coping-and-psychosocial-outcomes-in-caregivers-of-individuals-with-brain-injury
#7
Samantha DeDios-Stern, Eun-Jeong Lee
OBJECTIVE: Acquired brain injury (ABI) is associated with many physical and psychiatric conditions. Oftentimes, the individual's family members are responsible for providing long-term care, leaving caregivers vulnerable to negative effects of caregiving including stress, depression, and decreased quality of life. Attribution theory suggests that caregivers may blame the individual with the ABI for their injury as a way to understand their own circumstances. The objective of this study was to investigate caregiver coping strategies as possible mediators between caregiver family member blame and caregiver psychosocial outcomes among caregivers of individuals with ABI...
April 27, 2017: Rehabilitation Psychology
https://www.readbyqxmd.com/read/28447273/patients-awareness-usage-and-impact-of-hospital-report-cards-in-the-us
#8
Martin Emmert, Mark Schlesinger
BACKGROUND: Little knowledge is available about the importance of hospital report cards in the US from the patients' perspective. It also remains unknown whether specific report cards with a stronger emphasis on clinical measures have a greater impact on hospital choice than general report cards that focus on online-derived ratings. OBJECTIVE: The aim of this study was to determine the awareness and usage of hospital report cards as well as their impact on hospital choice in the US...
April 26, 2017: Patient
https://www.readbyqxmd.com/read/28447254/the-effect-of-an-online-referral-system-on-referrals-to-bariatric-surgery
#9
Aristithes G Doumouras, Sama Anvari, Ruth Breau, Mehran Anvari, Dennis Hong, Scott Gmora
BACKGROUND: The Ontario Bariatric Network implemented an online referral system to completely replace a fax-based system in 2015. Strategies such as electronic information transfer have been suggested to improve the bariatric referral process but few studies exist demonstrating their efficacy. Therefore, the purpose of this study was to determine the impact on referral rates to bariatric surgery after converting to an online referral system from a fax-based system. METHODS: All referrals from 2011 to 2015 were included in the study...
April 26, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28447222/feeding-strategies-in-pediatric-cancer-patients-with-gastrointestinal-mucositis-a-multicenter-prospective-observational-study-and-international-survey
#10
Nicoline S S Kuiken, Edmond H H M Rings, Marry M van den Heuvel-Eibrink, Marianne D van de Wetering, Wim J E Tissing
INTRODUCTION: Currently, there is no adequate prevention or treatment for both oral and gastrointestinal mucositis induced by chemotherapy and/or radiotherapy. Supportive care of symptoms plays a primary role during mucositis in the pediatric clinical setting. We aimed to get insight in the currently used feeding strategies in clinical practice in pediatric cancer patients with chemotherapy-induced mucositis. METHODS: A prospective observational study was performed to identify feeding strategies after chemotherapy courses causing mucositis in almost all patients at the University Medical Center Groningen (UMCG), the Academic Medical Center Amsterdam (AMC), and the Princess Maxima Center Utrecht (PMC)...
April 26, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28446527/the-value-of-different-aspects-of-person-centred-care-a-series-of-discrete-choice-experiments-in-people-with-long-term-conditions
#11
Christopher D Burton, Vikki A Entwistle, Alison M Elliott, Nicolas Krucien, Terry Porteous, Mandy Ryan
OBJECTIVE: To measure the value the patients place on different aspects of person-centred care. DESIGN: We systematically identified four attributes of person-centred care. We then measured their value to 923 people with either chronic pain or chronic lung disease over three discrete choice experiments (DCEs) about services to support self-management. We calculated the value of each attribute for all respondents and identified groups of people with similar preferences using latent class modelling...
April 26, 2017: BMJ Open
https://www.readbyqxmd.com/read/28446367/problematic-social-media-use-and-depressive-symptoms-among-u-s-young-adults-a-nationally-representative-study
#12
Ariel Shensa, César G Escobar-Viera, Jaime E Sidani, Nicholas D Bowman, Michael P Marshal, Brian A Primack
RATIONALE: Depression is the leading cause of disability worldwide. The suggested association between social media use (SMU) and depression may be explained by the emerging maladaptive use pattern known as problematic social media use (PSMU), characterized by addictive components. OBJECTIVE: We aimed to assess the association between PSMU and depressive symptoms-controlling for overall time and frequency of SMU-among a large sample of U.S. young adults. METHODS: In October 2014, participants aged 19-32 (N = 1749) were randomly selected from a nationally-representative U...
April 6, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28445351/breast-cancer-and-reconstruction-normative-data-for-interpreting-the-breast-q
#13
Lily R Mundy, Karen Homa, Anne F Klassen, Andrea L Pusic, Carolyn L Kerrigan
BACKGROUND: The BREAST-Q is a patient-reported outcome instrument used to evaluate outcomes in patients undergoing breast cancer surgery and reconstruction. Normative values for the BREAST-Q breast cancer modules have not been established, limiting data interpretation. METHODS: Participants were recruited by means of the Army of Women, an online community of women (with and without breast cancer), to complete Mastectomy, Breast Conserving Therapy, and Reconstruction preoperative BREAST-Q scales...
May 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28444879/prioritising-treatment-outcomes-how-people-with-acne-vulgaris-decide-if-their-treatment-is-working
#14
Alison M Layton, Heather Whitehouse, E Anne Eady, Fiona Cowdell, Katherine L Warburton, Mark Fenton
AIM: To collect information about how people with acne make day-to-day decisions concerning the effectiveness of their treatment. METHODS: Between May and August 2013, an optional question was embedded in the James Lind Alliance Acne Priority Setting Partnership's online survey to collect treatment uncertainties. The question asked people with acne to 'Tell us in your own words how you decide if your treatment has been effective'. RESULTS: A total of 742 respondents specified at least one outcome or means of assessing change (outcome measure)...
April 26, 2017: Journal of Evidence-based Medicine
https://www.readbyqxmd.com/read/28444507/heuristics-and-bias-in-rectal-surgery
#15
Ewan MacDermid, Christopher J Young, Susan J Moug, Robert G Anderson, Heather L Shepherd
PURPOSE: Deciding to defunction after anterior resection can be difficult, requiring cognitive tools or heuristics. From our previous work, increasing age and risk-taking propensity were identified as heuristic biases for surgeons in Australia and New Zealand (CSSANZ), and inversely proportional to the likelihood of creating defunctioning stomas. We aimed to assess these factors for colorectal surgeons in the British Isles, and identify other potential biases. METHODS: The Association of Coloproctology of Great Britain and Ireland (ACPGBI) was invited to complete an online survey...
April 25, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/28444169/androgen-receptor-regulation-of-local-growth-hormone-in-prostate-cancer-cells
#16
M V Recouvreux, B Wu, A C Gao, S Zonis, V Chesnokova, N Bhowmick, L W Chung, S Melmed
Prostate cancer (PCa) growth is mainly driven by androgen receptor (AR), and tumors that initially respond to androgen deprivation therapy (ADT) or AR inhibition usually relapse into a more aggressive, castration resistant stage (CRPC). Circulating growth hormone (GH) has a permissive role in PCa development in animal models and in human PCa xenograft growth. As GH and GH receptor (GHR) are both expressed in PCa cells, we assessed whether prostatic GH production is linked to AR activity and whether GH contributes to the castration resistant phenotype...
April 21, 2017: Endocrinology
https://www.readbyqxmd.com/read/28444126/cimbinator-a-web-based-tool-for-drug-synergy-analysis-in-small-and-large-scale-datasets
#17
Åsmund Flobak, Miguel Vazquez, Astrid Lægreid, Alfonso Valencia
Motivation: Drug synergies are sought to identify combinations of drugs particularly beneficial. User-friendly software solutions that can assist analysis of large-scale datasets are required. Results: CImbinator is a web-service that can aid in batch-wise and in-depth analyzes of data from small-scale and large-scale drug combination screens. CImbinator offers to quantify drug combination effects, using both the commonly employed median effect equation, as well as advanced experimental mathematical models describing dose response relationships...
April 19, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28443696/the-development-and-modelling-of-devices-and-paradigms-for-transcranial-magnetic-stimulation
#18
Stefan M Goetz, Zhi-De Deng
Magnetic stimulation is a non-invasive neurostimulation technique that can evoke action potentials and modulate neural circuits through induced electric fields. Biophysical models of magnetic stimulation have become a major driver for technological developments and the understanding of the mechanisms of magnetic neurostimulation and neuromodulation. Major technological developments involve stimulation coils with different spatial characteristics and pulse sources to control the pulse waveform. While early technological developments were the result of manual design and invention processes, there is a trend in both stimulation coil and pulse source design to mathematically optimize parameters with the help of computational models...
April 26, 2017: International Review of Psychiatry
https://www.readbyqxmd.com/read/28443377/association-of-microrna-146a-and-microrna-149-polymorphisms-with-strokes-in-asian-populations-an-updated-meta-analysis
#19
Jiaxiu Du, Chuanju Cui, Shuling Zhang, Xiaopeng Yang, Jiyu Lou
Strokes are a major cause of disability and death worldwide. An association between microRNA-146a (miR-146a) and miR-149 polymorphisms and strokes was inconclusive. This meta-analysis aimed to reevaluate the strength of the association by searching online databases and retrieving relevant case-control studies published between 2000 and 2016. Nine articles including 8 on miR-146a rs2910164 G/C and 3 on miR-149 rs2292832 C/T in 3372 patients with stroke and 4394 controls were included. The miR-149 rs2292832 was significantly associated with the risk of a stroke under allelic (C vs T: odds ratio [OR] = 1...
January 1, 2017: Angiology
https://www.readbyqxmd.com/read/28442780/the-effect-of-body-composition-and-serum-inflammatory-markers-on-the-functional-muscle-bone-unit-in-premenopausal-women
#20
S M Mueller, I Herter-Aeberli, A C Cepeda-Lopez, M Flück, H H Jung, M Toigo
BACKGROUND/OBJECTIVES: A number of recent studies dealing with the relationship between the effects of high body mass (BM) and fat mass (FM) on bone mass and strength exhibit a range of contrasting variations in their findings. These diverse findings have led to an ongoing controversy as to whether high BM and FM positively or negatively affect bone mass and strength. Excessive fat mass and the associated low-grade inflammation might overturn the higher mechanical stimulus arising from a higher body mass...
April 26, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
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