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https://www.readbyqxmd.com/read/29169200/-german-language-version-and-validation-of-the-risk-taking-behaviour-scale-rbs-k-for-high-risk-sports
#1
Anika Frühauf, Martin Niedermeier, Gerhard Ruedl, Matthew Barlow, Tim Woodman, Martin Kopp
Background High-risk sports, particularly climbing, kayaking and extreme skiing, have become increasingly popular. The most widely used psychological survey instrument with regard to risk behaviour in sports is the Sensation Seeking Model, mostly assessed by the Sensation Seeking Scale (SSS-V). Until recently, the literature discussed risk behaviour solely through this model. However, this scale does not measure risk-taking behaviours. In contrast, the Risk-Taking Behaviour Scale (RBS-K) is a three-item scale that measures risk behaviour in high-risk sports...
November 23, 2017: Sportverletzung Sportschaden: Organ der Gesellschaft Für Orthopädisch-Traumatologische Sportmedizin
https://www.readbyqxmd.com/read/29169183/myc-regulation-of-glutamine-proline-regulatory-axis-is-key-in-luminal-b-breast-cancer
#2
Madeleine L Craze, Hayley Cheung, Natasha Jewa, Nuno D M Coimbra, Daniele Soria, Rokaya El-Ansari, Mohammed A Aleskandarany, Kiu Wai Cheng, Maria Diez-Rodriguez, Christopher C Nolan, Ian O Ellis, Emad A Rakha, Andrew R Green
BACKGROUND: Altered cellular metabolism is a hallmark of cancer and some are reliant on glutamine for sustained proliferation and survival. We hypothesise that the glutamine-proline regulatory axis has a key role in breast cancer (BC) in the highly proliferative classes. METHODS: Glutaminase (GLS), pyrroline-5-carboxylate synthetase (ALDH18A1), and pyrroline-5-carboxylate reductase 1 (PYCR1) were assessed at DNA/mRNA/protein levels in large, well-characterised cohorts...
November 23, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/29169181/inflammatory-cytokine-il-8-cxcl8-promotes-tumour-escape-from-hepatocyte-induced-dormancy
#3
Ahmad S Khazali, Amanda M Clark, Alan Wells
BACKGROUND: Breast cancers can recur after a long latency period following 'successful' primary treatments. Chronic inflammation significantly correlates with reduced diseased-free survival in breast cancer patients and could be a point of intervention to prevent recurrence. Liver is among the main sites of breast cancer recurrence. Thus, we hypothesise that inflammatory signals from hepatic stellate cells, the major inflammatory regulators in the sinusoid, could stimulate dormant cancer cells to emerge...
November 23, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/29168680/should-health-care-organizations-use-information-gleaned-from-organization-sponsored-patient-support-groups-in-strategic-planning
#4
Priya Nambisan
Online forums and partnerships with patients have several benefits, such as the creation of new products and services. However, as with any such initiatives, there are risks as well as benefits. Through analysis of a case of misinformation being spread through a health care provider-sponsored online support group for patients dealing with obesity, this article outlines best practices and strategies to deploy in such organization-sponsored patient support groups. These strategies would enable organizations and patients to use such forums to the fullest extent while preventing or managing their potential risks as best as possible...
November 1, 2017: AMA Journal of Ethics
https://www.readbyqxmd.com/read/29168034/physical-activity-among-cancer-survivors-what-is-their-perception-and-experience
#5
Jan-Christoph Höh, Thorsten Schmidt, Jutta Hübner
PURPOSE: Physical activity (PA) plays an important role relating to cancer. The aim of this study was to investigate the attitude to and experience with the subject of PA in cancer in a large group of tumour patients. METHODS: A standardised questionnaire was carried out and distributed to patients online and in printed form. RESULTS: Nine hundred five patients answered the questionnaire. Most tumour patients (60%) received information about PA after their cancer therapy...
November 22, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29167106/use-of-a-primary-care-online-consultation-system-by-whom-when-and-why-evaluation-of-a-pilot-observational-study-in-36-general-practices-in-south-west-england
#6
Hannah B Edwards, Elsa Marques, William Hollingworth, Jeremy Horwood, Michelle Farr, Elly Bernard, Chris Salisbury, Kate Northstone
OBJECTIVES: Evaluation of a pilot study of an online consultation system in primary care. We describe who used the system, when and why, and the National Health Service costs associated with its use. DESIGN: 15-month observational study. SETTING: Primary care practices in South West England. RESULTS: 36 General practices covering 396 828 patients took part in the pilot. The online consultation website was viewed 35 981 times over the pilot period (mean 9...
November 22, 2017: BMJ Open
https://www.readbyqxmd.com/read/29166463/physicians-are-not-well-informed-about-the-new-guidelines-for-the-treatment-of-acute-stroke
#7
Luana Antunes Maranha Gatto, Gelson Luis Koppe, Zeferino Demartini, Viviane de Hiroki Flumignan Zétola
OBJECTIVE: Treatment of cerebrovascular disease has advanced rapidly in the last two decades. Recent data has added challenges to the treatment of ischemic stroke in the acute phase. OBJECTIVE: To evaluate the knowledge of physicians about the treatment of ischemic stroke in the acute phase. METHODS: An online questionnaire was submitted to all physicians enrolled in the Regional Council of Medicine in Brazil. RESULTS: 456 physicians from different specialties answered the questions...
October 2017: Arquivos de Neuro-psiquiatria
https://www.readbyqxmd.com/read/29166455/progression-and-prognosis-of-paravalvular-regurgitation-after-transcatheter-aortic-valve-implantation
#8
Rafael Alexandre Meneguz-Moreno, Antônio de Castro-Filho, Auristela Isabel de Oliveira Ramos, Mayra Zumarraga, David Le Bihan, Rodrigo Barretto, Dimytri Alexandre de Alvim Siqueira, Alexandre Antonio Cunha Abizaid, Amanda Guerra de Moraes Rego Sousa, J Eduardo Sousa
BACKGROUND: The impact of paravalvular regurgitation (PVR) following transcatheter aortic valve implantation (TAVI) remains uncertain. OBJECTIVE: To evaluate the impact of PVR on mortality and hospital readmission one year after TAVI. METHODS: Between January 2009 and June 2015, a total of 251 patients underwent TAVI with three different prostheses at two cardiology centers. Patients were assessed according to PVR severity after the procedure...
November 13, 2017: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/29166382/human-milk-h2o2-content-does-it-benefit-preterm-infants
#9
Monika Cieslak, Cristina H F Ferreira, Yulia Shifrin, Jingyi Pan, Jaques Belik
BACKGROUND: Human milk has a high content of the antimicrobial compound hydrogen peroxide (H2O2). As opposed to healthy full-term infants, preterm neonates are fed previously expressed and stored maternal milk. These practices may favor H2O2 decomposition, thus limiting its potential benefit to preterm infants. The goal of this study was to evaluate the factors responsible for H2O2 generation and degradation in breastmilk. METHODS: Human donors' and rat milk, along with rat mammary tissue were evaluated...
November 22, 2017: Pediatric Research
https://www.readbyqxmd.com/read/29166245/evidence-supporting-li-rads-major-features-for-ct-and-mr-imaging-based-diagnosis-of-hepatocellular-carcinoma-a-systematic-review
#10
An Tang, Mustafa R Bashir, Michael T Corwin, Irene Cruite, Christoph F Dietrich, Richard K G Do, Eric C Ehman, Kathryn J Fowler, Hero K Hussain, Reena C Jha, Adib R Karam, Adrija Mamidipalli, Robert M Marks, Donald G Mitchell, Tara A Morgan, Michael A Ohliger, Amol Shah, Kim-Nhien Vu, Claude B Sirlin
The Liver Imaging Reporting and Data System (LI-RADS) standardizes the interpretation, reporting, and data collection for imaging examinations in patients at risk for hepatocellular carcinoma (HCC). It assigns category codes reflecting relative probability of HCC to imaging-detected liver observations based on major and ancillary imaging features. LI-RADS also includes imaging features suggesting malignancy other than HCC. Supported and endorsed by the American College of Radiology (ACR), the system has been developed by a committee of radiologists, hepatologists, pathologists, surgeons, lexicon experts, and ACR staff, with input from the American Association for the Study of Liver Diseases and the Organ Procurement Transplantation Network/United Network for Organ Sharing...
November 21, 2017: Radiology
https://www.readbyqxmd.com/read/29165940/-use-of-clinical-practice-guidelines-in-medicine-what-s-new
#11
Oriane Aebischer, Mathilde Rochat, Marie Méan
Clinicians are confronted to an abundance of clinical practice guidelines (CPG). It has been proven for several pathologies that the use of guidelines improves quality of care by reducing mortality, the number of hospitalisations and the length of stay. Despite these proven benefits, adherence to CPGs remains low, mainly due to lack of awareness and familiarity with the guidelines, as well as lack of applicability and flexibility for elderly and comorbid patients. Since adherence to CPGs are influenced by their accessibility and format, informatics will certainly play an important role in the development and implementation of CPGs in the future...
November 22, 2017: Revue Médicale Suisse
https://www.readbyqxmd.com/read/29165571/reducing-ageism-education-about-aging-and-extended-contact-with-older-adults
#12
Ashley Lytle, Sheri R Levy, Suzanne Meeks
Background and Objectives: Ageism is of increasing concern due to the growing older population worldwide and youth-centered focus of many societies. Research Design and Methods: The current investigation tested the PEACE (Positive Education about Aging and Contact Experiences) model for the first time. Two online experimental studies examined 2 key factors for reducing ageism: education about aging (providing accurate information about aging) and extended contact (knowledge of positive intergenerational contact) as well as their potential combined effect (education plus extended contact)...
November 19, 2017: Gerontologist
https://www.readbyqxmd.com/read/29162574/doctors-perception-of-support-and-the-processes-involved-in-complaints-investigations-and-how-these-relate-to-welfare-and-defensive-practice-a-cross-sectional-survey-of-the-uk-physicians
#13
Tom Bourne, Bavo De Cock, Laure Wynants, Mike Peters, Chantal Van Audenhove, Dirk Timmerman, Ben Van Calster, Maria Jalmbrant
OBJECTIVE: How adverse outcomes and complaints are managed may significantly impact on physician well-being and practice. We aimed to investigate how depression, anxiety and defensive medical practice are associated with doctors actual and perceived support, behaviour of colleagues and process issues regarding how complaints investigations are carried out. DESIGN: A survey study. Respondents were classified into three groups: no complaint, recent/current complaint (within 6 months) or past complaint...
November 21, 2017: BMJ Open
https://www.readbyqxmd.com/read/29162297/administrative-evidence-based-practices-in-state-chronic-disease-practitioners
#14
Amy A Eyler, Cheryl Valko, Ramya Ramadas, Marti Macchi, Zarina Fershteyn, Ross C Brownson
INTRODUCTION: Research and lessons from community implementation have informed evidence-based practices that can improve the effectiveness of health initiatives. Administrative evidence-based practices (A-EBPs) facilitate the role of public health departments in implementing the most effective programs and policies. The purpose of this study is to describe A-EBPs in relation to characteristics of chronic disease practitioners in state health departments. METHODS: Randomly selected chronic disease practitioners who worked in state health departments were invited to complete an online survey in 2016...
November 18, 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/29162057/translating-a-child-care-based-intervention-for-online-delivery-development-and-randomized-pilot-study-of-go-napsacc
#15
Dianne S Ward, Amber E Vaughn, Stephanie Mazzucca, Regan Burney
BACKGROUND: As part of childhood obesity prevention initiatives, Early Care and Education (ECE) programs are being asked to implement evidence-based strategies that promote healthier eating and physical activity habits in children. Translation of evidence-based interventions into real world ECE settings often encounter barriers, including time constraints, lack of easy-to-use tools, and inflexible intervention content. This study describes translation of an evidence-based program (NAPSACC) into an online format (Go NAPSACC) and a randomized pilot study evaluating its impact on centers' nutrition environments...
November 21, 2017: BMC Public Health
https://www.readbyqxmd.com/read/29162043/exploring-consensus-on-how-to-measure-smoking-cessation-a-delphi-study
#16
Kei Long Cheung, Dennis de Ruijter, Mickaël Hiligsmann, Iman Elfeddali, Ciska Hoving, Silvia M A A Evers, Hein de Vries
BACKGROUND: Different criteria regarding outcome measures in smoking research are used, which can lead to confusion about study results. Consensus in outcome criteria may enhance the comparability of future studies. This study aims (1) to provide an overview of tobacco researchers' considered preferences regarding outcome criteria in randomized controlled smoking cessation trials, and (2) to identify the extent to which researchers can reach consensus on the importance of these outcome criteria...
November 21, 2017: BMC Public Health
https://www.readbyqxmd.com/read/29161266/knowledge-based-prediction-of-protein-backbone-conformation-using-a-structural-alphabet
#17
Iyanar Vetrivel, Swapnil Mahajan, Manoj Tyagi, Lionel Hoffmann, Yves-Henri Sanejouand, Narayanaswamy Srinivasan, Alexandre G de Brevern, Frédéric Cadet, Bernard Offmann
Libraries of structural prototypes that abstract protein local structures are known as structural alphabets and have proven to be very useful in various aspects of protein structure analyses and predictions. One such library, Protein Blocks, is composed of 16 standard 5-residues long structural prototypes. This form of analyzing proteins involves drafting its structure as a string of Protein Blocks. Predicting the local structure of a protein in terms of protein blocks is the general objective of this work...
2017: PloS One
https://www.readbyqxmd.com/read/29161241/determination-of-an-optimal-response-cut-off-able-to-predict-progression-free-survival-in-patients-with-well-differentiated-advanced-pancreatic-neuroendocrine-tumours-treated-with-sunitinib-an-alternative-to-the-current-recist-defined-response
#18
Angela Lamarca, Jorge Barriuso, Matthew Kulke, Ivan Borbath, Heinz-Josef Lenz, Jean Luc Raoul, Neal J Meropol, Catherine Lombard-Bohas, James Posey, Sandrine Faivre, Eric Raymond, Juan W Valle
BACKGROUND: Sunitinib prolongs progression-free survival (PFS) in patients with advanced pancreatic neuroendocrine tumours (pNET). Response Evaluation Criteria in Solid Tumors (RECIST)-defined partial responses (PR; classically defined as ⩾30% size decrease from baseline) are infrequent. METHODS: Individual data of pNET patients from the phase II [NCT00056693] and pivotal phase III [NCT00428597] trials of sunitinib were analysed in this investigator-initiated, post hoc study...
November 21, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/29161240/rapid-nodal-staging-of-head-and-neck-cancer-surgical-specimens-with-flow-cytometric-analysis
#19
Valtteri Häyry, Åsa Kågedal, Eric Hjalmarsson, Pedro Farrajota Neves da Silva, Cecilia Drakskog, Gregori Margolin, Susanna Kumlien Georén, Eva Munck-Wikland, Ola Winqvist, Lars Olaf Cardell
BACKGROUND: Detection of metastatic spread of head and neck cancer to cervical lymph nodes is essential for optimal design of therapy. Undetected metastases lead to mortality, which can be prevented by better detection methods. METHODS: We analysed 41 lymph nodes from 19 patients with oral squamous cell carcinoma (OSCC). Each lymph node was divided in two, one half processed for histopathology and the other half dissociated into single-cell suspension, stained for the carcinoma cell markers cytokeratin 5/8 (CK5/8), epithelial cell adhesion molecule (EpCAM) and epithelial mucin (MUC-1), and analysed with flow cytometry...
November 21, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/29158888/initial-evidence-that-non-clinical-autistic-traits-are-associated-with-lower-income
#20
William J Skylark, Simon Baron-Cohen
Among non-clinical samples, autistic traits correlate with a range of educational and social outcomes. However, previous work has not investigated the relationship between autistic traits and income, a key determinant of socio-economic status and well-being. In five studies (total N = 2491), we recruited participants without a diagnosis of autism from the general US population via an online platform and administered the short-form Autism Spectrum Quotient (AQ) as well as asked a range of demographic questions...
2017: Molecular Autism
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