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Sacral neuromodulation

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https://www.readbyqxmd.com/read/27920880/conditional-electrical-stimulation-in-animal-and-human-models-for-neurogenic-bladder-working-toward-a-neuroprosthesis
#1
C R Powell
Sacral neuromodulation has had a tremendous impact on the treatment of urinary incontinence and lower urinary tract symptoms for patients with neurologic conditions. This stimulation does not use real-time data from the body or input from the patient. Incorporating this is the goal of those pursuing a neuroprosthesis to enhance bladder function for these patients. Investigators have demonstrated the effectiveness of conditional (also called closed-loop) feedback in animal models as well as limited human studies...
December 2016: Current Bladder Dysfunction Reports
https://www.readbyqxmd.com/read/27915486/evaluation-of-the-axonics-modulation-technologies-sacral-neuromodulation-system-for-the-treatment-of-urinary-and-fecal-dysfunction
#2
Joshua A Cohn, Casey G Kowalik, Melissa R Kaufman, W Stuart Reynolds, Douglas F Milam, Roger R Dmochowski
Sacral neuromodulation (SNM) remains one of the few effective treatments for refractory bladder and bowel dysfunction. However, SNM is associated with frequent need for surgical intervention, in many cases because of a failed battery. A rechargeable SNM system, with a manufacturer-reported battery life of 15 years or more, has entered post-market clinical testing in Europe but has not yet been approved for clinical testing in the United States. Areas covered: We review existing neuromodulation technologies for the treatment of lower urinary tract and bowel dysfunction and explore the limitations of available technology...
December 4, 2016: Expert Review of Medical Devices
https://www.readbyqxmd.com/read/27885800/sacral-neuromodulation-for-the-treatment-of-faecal-incontinence-following-proctectomy
#3
Ido Mizrahi, Sami A Chadi, Nadav Haim, Dana R Sands, Brooke Gurland, Massarat Zutshi, Steven D Wexner, Giovanna da Silva
AIM: This study assessed the effectiveness of sacral neuromodulation (SNM) for faecal incontinence (FI) following proctectomy with colorectal or coloanal anastomosis. METHODS: An IRB-approved database identified patients treated for FI following proctectomy (SNM-P) for benign or malignant disease, who were matched 1:1 by pre-operative Cleveland Clinic Florida Faecal Incontinence Scores (CCF-FIS) with patients without proctectomy (SNM-NP). Primary outcome was change in CCF-FIS...
November 25, 2016: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/27822462/sacral-neuromodulation-in-overactive-bladder-a-review-and-current-perspectives
#4
REVIEW
Troy Sukhu, Michael J Kennelly, Raj Kurpad
Overactive bladder (OAB) symptoms of urgency, frequency, and urge incontinence currently affect a substantial portion of the population, especially as age increases. Sacral neuromodulation has become a popular option for refractory OAB symptoms over the past 2 decades. Studies have demonstrated that it is an effective treatment for OAB and urge incontinence as indicated by decreased number of voids, increased bladder capacity, and fewer leakage events. In addition, the effects have proved to be durable to multiple years following implantation...
2016: Research and Reports in Urology
https://www.readbyqxmd.com/read/27816462/-lower-urinary-tract-dysfunction-in-normal-pressure-hydrocephalus-review-of-the-literature
#5
E Bey, B Nicot, O Casez, L Le Normand
INTRODUCTION: Lower urinary tract dysfunction in normal pressure hydrocephalus has received little attention from the scientific community. The aim of this review article was to discuss diagnostic and therapeutic options for these patients. SOURCES: A literature review of MedLine publications on urinary incontinence in normal pressure hydrocephalus was conducted. The following keywords were used: "hydrocephalus, normal pressure" and "bladder dysfunction" or "urinary incontinence" or "overactive bladder" or "urinary bladder, neurogenic"...
December 2016: Progrès en Urologie
https://www.readbyqxmd.com/read/27749479/does-sacral-nerve-stimulation-improve-continence-through-enhanced-sensitivity-of-the-anal-canal-a-pilot-study
#6
S Haas, C Brock, K Krogh, M Gram, L Lundby, A M Drewes, S Laurberg
BACKGROUND: It has been suggested that the effects of sacral nerve stimulation against fecal incontinence involve neuromodulation at spinal or supraspinal levels. OBJECTIVE: This study aims to investigate the afferent sensory pathways from the anorectum before and during sacral nerve stimulation. DESIGN: This is an explorative study. PATIENTS: Fifteen women with idiopathic fecal incontinence (mean age, 58 ± 12.2 years) were selected...
November 2016: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/27742453/onabotulinumtoxina-is-preferred-over-sacral-neuromodulation-for-refractory-overactive-bladder
#7
David A Ginsberg
No abstract text is available yet for this article.
October 11, 2016: Journal of Urology
https://www.readbyqxmd.com/read/27742452/onabotulinumtoxina-is-preferred-over-sacral-neuromodulation-for-refractory-overactive-bladder
#8
Steven Siegel
No abstract text is available yet for this article.
October 11, 2016: Journal of Urology
https://www.readbyqxmd.com/read/27730701/neurotransmitter-mechanisms-underlying-sacral-neuromodulation-of-bladder-overactivity-in-cats
#9
Jathin Bandari, Utsav Bansal, Zhaocun Zhang, Bing Shen, Jicheng Wang, Vladimir Lamm, Victor Chang, James R Roppolo, William C de Groat, Changfeng Tai
OBJECTIVE: To determine the role of opioid, β-adrenergic, and metabotropic glutamate 5 receptors in sacral neuromodulation of bladder overactivity. MATERIAL AND METHODS: In α-chloralose anesthetized cats, intravesical infusion of 0.5% acetic acid (AA) irritated the bladder and induced bladder overactivity. Electric stimulation (5 Hz, 0.2 ms, 0.16-0.7V) of S1 or S2 sacral dorsal roots inhibited the bladder overactivity. Naloxone, propranolol, or MTEP were given intravenously (i...
October 12, 2016: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/27730097/development-of-a-ct-guided-standard-approach-for-tined-lead-implantation-at-the-sacral-nerve-root-s3-in-minipigs-for-chronic-neuromodulation
#10
Elena Esra Foditsch, Reinhold Zimmermann
PURPOSE: The aim of this study was to develop a controlled approach for sacral neuromodulation (SNM) to improve both nerve targeting and tined lead placement, for which a new computed tomography (CT)-guided implantation technique was analyzed in minipigs. MATERIALS AND METHODS: This study included five female, adult Göttingen minipigs. In deep sedoanalgesia, the minipigs were placed in an extended prone position. Commercially available SNM materials were used (needle, introduction sheath, and quadripolar tined lead electrode)...
2016: Research and Reports in Urology
https://www.readbyqxmd.com/read/27729478/contribution-of-gabaa-glycine-and-opioid-receptors-to-sacral-neuromodulation-of-bladder-overactivity-in-cats
#11
Xuewen Jiang, Thomas W Fuller, Jathin Bandari, Utsav Bansal, Zhaocun Zhang, Bing Shen, Jicheng Wang, James R Roppolo, William C de Groat, Changfeng Tai
In α-chloralose anesthetized cats, we examined the role GABAA, glycine, and opioid receptors in sacral neuromodulation-induced inhibition of bladder overactivity elicited by intravesical infusion of 0.5% acetic acid (AA). AA irritation significantly (p<0.01) reduced bladder capacity to 59.5±4.8% of saline control. S1 or S2 dorsal root stimulation at threshold intensity for inducing reflex twitching of the anal sphincter or toe significantly (p<0.01) increased bladder capacity to 105.3±9.0% and 134...
October 11, 2016: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/27706012/sacral-neuromodulation-in-patients-with-a-cardiac-pacemaker
#12
Abdullah A Gahzi, Dean S Elterman, Magdy Hassouna
The objective of this study was to describe our experience using sacral neuromodulation to treat urinary urgency, frequency, urge incontinence, and chronic urinary retention in patients with cardiac pacemakers. With the increasingly widespread use of InterStim for bladder function restoration, we are seeing more complex patients with multiple comorbidities, including cardiac conditions. Herein, we report 3 cases of individuals with cardiac pacemakers who underwent InterStim implantation to treat urinary conditions...
September 2016: International Neurourology Journal
https://www.readbyqxmd.com/read/27706006/percutaneous-nerve-evaluation-test-versus-staged-test-trials-for-sacral-neuromodulation-sensitivity-specificity-and-predictive-values-of-each-technique
#13
Mai Banakhar, Magdy Hassouna
PURPOSE: InterStim device is an U.S. Food and Drug Administration approved minimal invasive therapy for sacral neuromodulation for lower urinary tract dysfunction. Before InterStim implantation, a trial with the appropriate screening tests is required to determine patient therapy eligibility. There are two different techniques for patient screening: percutaneous nerve evaluation (PNE) test and staged test. Few studies have reported success and failure rates for each technique. However, test sensitivity and predictive values of either test have not been studied...
September 2016: International Neurourology Journal
https://www.readbyqxmd.com/read/27705733/a-standardized-surgical-technique-for-removal-of-the-interstim-tined-lead
#14
Matthew E Sterling, Siobhan M Hartigan, Alan J Wein, Ariana L Smith
INTRODUCTION: Explantation of the Interstim sacral neuromodulation (SNM) device is occasionally necessary. Removing the tined lead can put strain on the lead, resulting in a possible break and retained fragments. The Food and Drug Administration (FDA) released a notification regarding health consequences related to retained lead fragments. We describe a novel and safe surgical technique for removing the Interstim device and permanent lead. MATERIALS AND METHODS: We searched the Manufacturer and User Facility Device Experience (MAUDE) database for complications related to tined lead removal and searched the database of a single surgeon at our institution...
October 2016: Canadian Journal of Urology
https://www.readbyqxmd.com/read/27701661/onabotulinumtoxina-vs-sacral-neuromodulation-on-refractory-urgency-urinary-incontinence-in-women-a-randomized-clinical-trial
#15
Cindy L Amundsen, Holly E Richter, Shawn A Menefee, Yuko M Komesu, Lily A Arya, W Thomas Gregory, Deborah L Myers, Halina M Zyczynski, Sandip Vasavada, Tracy L Nolen, Dennis Wallace, Susan F Meikle
Importance: Women with refractory urgency urinary incontinence are treated with sacral neuromodulation and onabotulinumtoxinA with limited comparative information. Objective: To assess whether onabotulinumtoxinA is superior to sacral neuromodulation in controlling refractory episodes of urgency urinary incontinence. Design, Setting, and Participants: Multicenter open-label randomized trial (February 2012-January 2015) at 9 US medical centers involving 381 women with refractory urgency urinary incontinence...
October 4, 2016: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/27676890/one-handed-intermittent-self-urinary-catheterism-with-an-adaptive-equipment-case-report-of-an-amputee-patient-suffering-from-multiple-sclerosis
#16
Helene Dessort, Evelyne Castel-Lacanal, Xavier de Boissezon, Philippe Marque
OBJECTIVE: Intermittent self-catheterization is the gold standard for patients with central neurologic bladder. It allows to reduce all urinary tract complications and to improve the quality of life. The factors of good compliance are continence and autonomy regarding the introduction of the catheter. Nevertheless, self-catheterization can be difficult because of the usual shortcomings associated with bladder and sphincter disorders (motor, sensory…). We found only one study about one adaptive equipment to facilitate the gesture for monoplegic patients...
September 2016: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/27676716/dystonia-of-the-lower-limb-after-sacral-neuromodulation-implanted-to-a-16-year-old-boy-with-non-obstructive-chronic-urinary-retention
#17
Teng Maëlys, Gilberte Robain, Samy Bendaya
OBJECTIVE: Sacral neuromodulation is usually used to treat non-obstructive urinary retention when other forms of treatment have failed. An improvement greater than 50% in urinary symptoms after 40months of follow-up has been shown: - moreover, it also has few complications: infections, technical failures, discomfort; - we report a case of dystonia of the lower limb, appeared after sacral neuromodulation implantation. OBSERVATIONS: MMP is a 16-year-old boy with early puberty as noteworthy medical history...
September 2016: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/27676460/the-impact-of-prior-back-surgery-on-neuromodulation-outcomes-a-review-of-over-500-patients
#18
Jamie M Bartley, Kim A Killinger, Judith A Boura, Priyanka Gupta, Natalie Gaines, Jason P Gilleran, Kenneth M Peters
AIMS: To evaluate neuromodulation outcomes in patients with prior back surgery. METHODS: Adults in our prospective observational sacral/pudendal neuromodulation study were retrospectively evaluated. History and operative details were reviewed, and outcomes were measured at 3, 6, 12, and 24 months with overactive bladder questionnaire (OAB q) symptom severity (SS)/health related quality of life (HRQOL), interstitial cystitis symptom/problem indices (ICSI - PI), voiding diaries, and global response assessments (GRA)...
September 27, 2016: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/27636222/outcomes-of-sacral-neuromodulation-in-patients-with-prior-surgical-treatment-of-stress-urinary-incontinence-and-pelvic-organ-prolapse
#19
Jamie M Bartley, Verity Ramirez, Kim A Killinger, Judith A Boura, Priyanka Gupta, Natalie Gaines, Jason P Gilleran, Kenneth M Peters
OBJECTIVES: The aim of this study was to evaluate the efficacy of sacral neuromodulation in patients with prior stress urinary incontinence (SUI) or pelvic organ prolapse (POP) surgery. METHODS: Women in our prospective neuromodulation database were evaluated. Patients with a history of prior SUI/POP surgery were compared to those without. Medical records at baseline were reviewed, and primary outcome was defined as moderate/marked improvement on Global Response Assessment (GRA) at 3 months...
September 15, 2016: Female Pelvic Medicine & Reconstructive Surgery
https://www.readbyqxmd.com/read/27629495/specific-tips-for-general-controversies-in-sacral-neuromodulation
#20
REVIEW
Ahmed S El-Azab, Steven W Siegel
The field of Sacral Neuromodulation is continually evolving and still in its infancy. Common dilemmas experienced with this therapy will be discussed in this article, including ways to avoid and manage them. The focus will be on test evaluations performed with either peripheral nerve evaluation (PNE) or staged procedure, the clinical effectiveness and safety of unilateral versus bilateral test stimulation for both the PNE and staged procedures, and best methods to determine the success of the trial phase. We will also discuss how to deal with the problem of declining efficacy of the device over time...
November 2016: Current Urology Reports
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