Nathan L Price, Pablo Fernández-Tussy, Luis Varela, Magdalena P Cardelo, Marya Shanabrough, Binod Aryal, Rafael de Cabo, Yajaira Suárez, Tamas L Horvath, Carlos Fernández-Hernando
AgRP neurons drive hunger, and excessive nutrient intake is the primary driver of obesity and associated metabolic disorders. While many factors impacting central regulation of feeding behavior have been established, the role of microRNAs in this process is poorly understood. Utilizing unique mouse models, we demonstrate that miR-33 plays a critical role in the regulation of AgRP neurons, and that loss of miR-33 leads to increased feeding, obesity, and metabolic dysfunction in mice. These effects include the regulation of multiple miR-33 target genes involved in mitochondrial biogenesis and fatty acid metabolism...
March 8, 2024: Nature Communications