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Yoshikazu Suzuki cardiac

Reilly Hobbs, Varun Korutla, Yoshikazu Suzuki, Michael Acker, Prashanth Vallabhajosyula
Ventricular septal defect (VSD) after myocardial infarction (MI) is an uncommon but serious complication. Patients refractory to attempts at medical stabilization and requiring emergency surgery have expected mortality rates greater than 50%. We present three cases of extracorporeal membrane oxygenation bridge to surgical repair in patients with multisystem organ failure who would otherwise require emergent cardiac surgery with associated risk and review the literature for mechanical circulatory support for patients with anterior and posterior post-MI VSD...
June 2015: Journal of Cardiac Surgery
Natsuko Hemmi, Shugo Tohyama, Kazuaki Nakajima, Hideaki Kanazawa, Tomoyuki Suzuki, Fumiyuki Hattori, Tomohisa Seki, Yoshikazu Kishino, Akinori Hirano, Marina Okada, Ryota Tabei, Rei Ohno, Chihana Fujita, Tomoko Haruna, Shinsuke Yuasa, Motoaki Sano, Jun Fujita, Keiichi Fukuda
Cardiac regenerative therapy with human pluripotent stem cells (hPSCs), such as human embryonic stem cells and induced pluripotent stem cells, has been hampered by the lack of efficient strategies for expanding functional cardiomyocytes (CMs) to clinically relevant numbers. The development of the massive suspension culture system (MSCS) has shed light on this critical issue, although it remains unclear how hPSCs could differentiate into functional CMs using a MSCS. The proliferative rate of differentiating hPSCs in the MSCS was equivalent to that in suspension cultures using nonadherent culture dishes, although the MSCS provided more homogeneous embryoid bodies (EBs), eventually reducing apoptosis...
December 2014: Stem Cells Translational Medicine
Tomohisa Seki, Shinsuke Yuasa, Dai Kusumoto, Akira Kunitomi, Yuki Saito, Shugo Tohyama, Kojiro Yae, Yoshikazu Kishino, Marina Okada, Hisayuki Hashimoto, Makoto Takei, Toru Egashira, Masaki Kodaira, Yusuke Kuroda, Atsushi Tanaka, Shinichiro Okata, Tomoyuki Suzuki, Mitsushige Murata, Jun Fujita, Keiichi Fukuda
Induced pluripotent stem cells (iPSCs) have been proposed as novel cell sources for genetic disease models and revolutionary clinical therapies. Accordingly, human iPSC-derived cardiomyocytes are potential cell sources for cardiomyocyte transplantation therapy. We previously developed a novel generation method for human peripheral T cell-derived iPSCs (TiPSCs) that uses a minimally invasive approach to obtain patient cells. However, it remained unknown whether TiPSCs with genomic rearrangements in the T cell receptor (TCR) gene could differentiate into functional cardiomyocyte in vitro...
2014: PloS One
Yukiko Nakano, Kazuaki Chayama, Hidenori Ochi, Masaaki Toshishige, Yasufumi Hayashida, Daiki Miki, C Nelson Hayes, Hidekazu Suzuki, Takehito Tokuyama, Noboru Oda, Kazuyoshi Suenari, Yuko Uchimura-Makita, Kenta Kajihara, Akinori Sairaku, Chikaaki Motoda, Mai Fujiwara, Yoshikazu Watanabe, Yukihiko Yoshida, Kimie Ohkubo, Ichiro Watanabe, Akihiko Nogami, Kanae Hasegawa, Hiroshi Watanabe, Naoto Endo, Takeshi Aiba, Wataru Shimizu, Seiko Ohno, Minoru Horie, Koji Arihiro, Satoshi Tashiro, Naomasa Makita, Yasuki Kihara
Unexplained cardiac arrest (UCA) with documented ventricular fibrillation (VF) is a major cause of sudden cardiac death. Abnormal sympathetic innervations have been shown to be a trigger of ventricular fibrillation. Further, adequate expression of SEMA3A was reported to be critical for normal patterning of cardiac sympathetic innervation. We investigated the relevance of the semaphorin 3A (SEMA3A) gene located at chromosome 5 in the etiology of UCA. Eighty-three Japanese patients diagnosed with UCA and 2,958 healthy controls from two different geographic regions in Japan were enrolled...
April 2013: PLoS Genetics
Jinya Suzuki, Masami Ueno, Miyuki Uno, Yoshikazu Hirose, Yasuo Zenimaru, Sadao Takahashi, Jun-Ichi Osuga, Shun Ishibashi, Masafumi Takahashi, Masamichi Hirose, Mitsuhiko Yamada, Fredric B Kraemer, Isamu Miyamori
Increased fatty acid (FA) flux and intracellular lipid accumulation (steatosis) give rise to cardiac lipotoxicity in both pathological and physiological conditions. Since hormone-sensitive lipase (HSL) contributes to intracellular lipolysis in adipose tissue and heart, we investigated the impact of HSL disruption on cardiac energy metabolism in response to fasting and refeeding. HSL-knockout (KO) mice and wild-type (WT) littermates were fasted for 24 h, followed by ∼6 h of refeeding. Plasma FA concentration in WT mice was elevated twofold with fasting, whereas KO mice lacked this elevation, resulting in twofold lower cardiac FA uptake compared with WT mice...
November 2009: American Journal of Physiology. Endocrinology and Metabolism
Yoshikazu Suzuki, Francis D Pagani, Steven F Bolling
BACKGROUND: There are limited reports describing multiple-time redo mitral valve surgery using a left thoracotomy approach and on-pump beating heart technique. METHODS: A retrospective review of medical records for 16 patients from March 2002 to June 2007 was performed. RESULTS: Mean age was 54 +/- 17 (mean +/- SD) years (8 males). Preoperative mitral valve regurgitation was 3.6 +/- 0.6 in 14, and 2 had severe mitral valve stenosis. New York Heart Association symptom class was 2...
August 2008: Annals of Thoracic Surgery
Daisuke Fujioka, Yukio Saito, Tsuyoshi Kobayashi, Toshiaki Yano, Hideo Tezuka, Yoshikazu Ishimoto, Noriko Suzuki, Yasunori Yokota, Takamitsu Nakamura, Jyun-ei Obata, Masaki Kanazawa, Ken-ichi Kawabata, Kohji Hanasaki, Kiyotaka Kugiyama
BACKGROUND: Group X secretory phospholipase A(2) (sPLA(2)-X) has the most potent hydrolyzing activity toward phosphatidylcholine and elicits a marked release of arachidonic acid among several types of sPLA(2). sPLA(2)-X is expressed in neutrophils, but its pathogenic role remains unclear. METHODS AND RESULTS: We generated mice that lack sPLA(2)-X and studied their response to myocardial ischemia/reperfusion. The sPLA(2)-X(-/-) mice had a significant reduction in myocardial infarct size and a decrease in myocardial myeloperoxidase activity compared with sPLA(2)-X(+/+) mice...
June 10, 2008: Circulation
Takefumi Takahashi, Yoshikazu Hiasa, Yoshikazu Ohara, Shin-Ichiro Miyazaki, Riyo Ogura, Naoki Suzuki, Shinobu Hosokawa, Koichi Kishi, Ryuji Ohtani
BACKGROUND: The relationship of admission neutrophil count to the degree of microvascular injury, left ventricular (LV) volume, and long-term outcome after acute myocardial infarction (AMI) was examined in the present study. METHODS AND RESULTS: The study group comprised 228 consecutive patients with a first anterior wall AMI who underwent primary angioplasty within 12 h of onset. The degree of microvascular injury was evaluated by Doppler guidewire. Adverse cardiac events were recorded during an average follow-up of 52+/-28 months...
June 2008: Circulation Journal: Official Journal of the Japanese Circulation Society
Takefumi Takahashi, Yoshikazu Hiasa, Yoshikazu Ohara, Shin-Ichiro Miyazaki, Riyo Ogura, Hitoshi Miyajima, Ken-Ichiro Yuba, Naoki Suzuki, Shinobu Hosokawa, Koichi Kishi, Ryuji Ohtani
Coronary flow reserve (CFR) evaluated immediately after reperfusion is thought to reflect the degree of microvascular injury and predict left ventricular (LV) functional recovery after acute myocardial infarction. It was hypothesized that CFR immediately after reperfusion would be predictive of the occurrence of long-term adverse cardiac events. Using a Doppler guidewire, CFR was evaluated immediately after primary coronary angioplasty in 118 consecutive patients with first anterior acute myocardial infarctions...
September 1, 2007: American Journal of Cardiology
Takahiro Matsuno, Osamu Ishida, Toru Sunagawa, Osami Suzuki, Yoshikazu Ikuta, Mitsuo Ochi
PURPOSE: We performed radius lengthening to treat radial deviation of the wrist in patients with Bayne and Klug type II and type III radial longitudinal deficiencies. The purpose of this investigation was to review our results of radius lengthening for radial longitudinal deficiency. METHODS: Beginning in 1991 radius lengthening was performed to treat 4 patients with radial longitudinal deficiency whose mean age at the initial lengthening was 16 months. The corrections for radial deviation of the wrists were performed simultaneously by soft-tissue distraction of the wrist...
May 2006: Journal of Hand Surgery
Yoshikazu Ohara, Yoshikazu Hiasa, Shinobu Hosokawa, Shinichiro Miyazaki, Riyo Ogura, Hitoshi Miyajima, Kenichiro Yuba, Naoki Suzuki, Takefumi Takahashi, Koichi Kishi, Ryuji Ohtani
Hydroxymethyglutaryl coenzyme A reductase inhibition (statin) therapy has been shown to reduce cardiac hypertrophy in vitro and in vivo. We assessed the influence of short-term statin therapy on left ventricular (LV) remodeling after acute myocardial in-farction. Thirty-five patients with first anterior acute myocardial infarction, who underwent primary coronary angioplasty within 12 hours of onset, were divided into 2 groups. Ten patients taking statin served as the statin group, and 25 patients not taking statin served as the control group...
November 2005: International Heart Journal
Yoshikazu Ohara, Yoshikazu Hiasa, Shinobu Hosokawa, Takeshi Tomokane, Koji Yamaguchi, Riyo Ogura, Hitoshi Miyajima, Taturo Ogata, Kenichiro Yuba, Naoki Suzuki, Takefumi Takahashi, Koichi Kishi, Ryuji Ohtani
A 79-year-old woman presented with chest pain. Her symptoms, combined with the results of an electrocardiogram, echocardiogram and laboratory investigations were compatible with an extensive acute anterior myocardial infarction. However, emergency coronary angiography showed no stenotic lesion in any coronary artery, but left ventriculography revealed apical ballooning akinesis and basal hyperkinesis and she was diagnosed as having transient left ventricular apical ballooning. After 7 days, she suddenly went into cardiopulmonary arrest because of cardiac tamponade...
May 2005: Circulation Journal: Official Journal of the Japanese Circulation Society
Masayuki Arakawa, Masataka Shiozuka, Yuki Nakayama, Takahiko Hara, Masa Hamada, Shin'ichi Kondo, Daishiro Ikeda, Yoshikazu Takahashi, Ryuichi Sawa, Yoshiaki Nonomura, Kianoush Sheykholeslami, Kenji Kondo, Kimitaka Kaga, Toshio Kitamura, Yuko Suzuki-Miyagoe, Shin'ichi Takeda, Ryoichi Matsuda
The ability of aminoglycoside antibiotics to promote read-through of nonsense mutations has attracted interest in these drugs as potential therapeutic agents in genetic diseases. However, the toxicity of aminoglycoside antibiotics may result in severe side effects during long-term treatment. In this paper, we report that negamycin, a dipeptide antibiotic, also restores dystrophin expression in skeletal and cardiac muscles of the mdx mouse, an animal model of Duchenne muscular dystrophy (DMD) with a nonsense mutation in the dystrophin gene, and in cultured mdx myotubes...
November 2003: Journal of Biochemistry
Yoshikazu Goto, Ichiro Suzuki, Hideo Inaba
This study determined whether electrocardiographic analysis of ventricular fibrillation (VF) can predict 1-year survival from bystander-witnessed, out-of-hospital cardiac arrests of cardiac origin. VF was analyzed using fast-Fourier transformation in a community in which emergency medical technicians delivered shock with an automated external defibrillator before arrival to the hospital. The frequency of VF can predict survival 1 year after hospital discharge from shock-delivered, bystander-witnessed cardiac arrests of cardiac etiology...
August 15, 2003: American Journal of Cardiology
Hiroki Kasai, Jun-ichi Suzuki, Hiroshi Imamura, Yoshikazu Yazaki, Mitsuaki Isobe, Morie Sekiguchi
We present a case of cardiac sarcoidosis with advanced atrioventricular (AV) block in a 45-year-old female patient. Although endomyocardial biopsy and other diagnostic findings were inconclusive, gastrocnemial muscle biopsy indicated a definitive diagnosis of sarcoidosis. Whole-body gallium-67 scintigraphy was useful to confirm the suspicion of the presence of sarcoidosis. Thereafter, magnetic resonance imaging (MRI) was successful in detecting the space-occupying lesion in the skeletal muscle, leading to a positive diagnosis of sarcoidosis...
March 2003: Heart and Vessels
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