Sunjay Kaushal, Joshua M Hare, Jessica R Hoffman, Riley M Boyd, Kevin N Ramdas, Nicholas Pietris, Shelby Kutty, James S Tweddell, S Adil Husain, Shaji C Menon, Linda M Lambert, David A Danford, Seth J Kligerman, Narutoshi Hibino, Laxminarayana Korutla, Prashanth Vallabhajosyula, Michael J Campbell, Aisha Khan, Eric Naioti, Keyvan Yousefi, Danial Mehranfard, Lisa McClain-Moss, Anthony A Oliva, Michael E Davis
AIMS: Hypoplastic left heart syndrome (HLHS) survival relies on surgical reconstruction of the right ventricle (RV) to provide systemic circulation. This substantially increases the RV load, wall stress, maladaptive remodelling, and dysfunction, which in turn increases the risk of death or transplantation. METHODS AND RESULTS: We conducted a phase 1 open-label multicentre trial to assess the safety and feasibility of Lomecel-B as an adjunct to second-stage HLHS surgical palliation...
March 2023: Eur Heart J Open