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https://www.readbyqxmd.com/read/27866925/extracorporeal-membrane-oxygenation-support-and-post-heart-transplant-outcomes-among-united-states-adults
#1
Sandip Zalawadiya, Marat Fudim, Geetha Bhat, William Cotts, JoAnn Lindenfeld
BACKGROUND: Patients supported with extracorporeal membrane oxygenation (ECMO) are given priority listing status for heart transplant (HT). Data on post-HT outcomes for adults with ECMO support at the time of HT are limited. METHODS: We analyzed data from the United Network for Organ Registry (UNOS) registry for 157 ECMO-supported adults (age ≥ 18 years) undergoing HT after January 1, 2000. Data at the time of HT were examined for their association with post-transplant mortality using multivariable Cox proportional hazard analyses...
October 15, 2016: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/27779776/a-phase-i-study-to-determine-the-pharmacokinetic-profile-safety-and-tolerability-of-sildenafil-revatio-%C3%A2-in-cardiac-surgery-the-revaki-1-study
#2
Arne Ring, Tom Morris, Marcin Wozniak, Nikol Sullo, William Dott, Veerle Verheyden, Tracy Kumar, Nigel Brunskill, Rakesh Vaja, Gavin J Murphy
AIMS: Acute kidney injury (AKI) is a common and severe complication of cardiac surgery. There is no effective prevention or treatment. Sildenafil citrate (Revatio(®) , Pfizer Inc.), a phosphodiesterase type 5 inhibitor, prevents post cardiac surgery AKI in pre-clinical studies, however its use is contraindicated in patients with symptomatic cardiovascular disease. The aim of this study is to assess the safety and pharmacokinetics of intravenous sildenafil in cardiac surgery patients...
October 25, 2016: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/27726057/recovery-of-renal-dysfunction-after-catheter-ablation-of-outflow-tract-ventricular-arrhythmias-in-patients-with-ventricular-premature-depolarization-mediated-cardiomyopathy
#3
Shingo Maeda, William W Chik, Jackson J Liang, Iosif Kelesidis, Ruben Casado Arroyo, Benjamin D'Souza, Mouhannad M Sadek, Daniele Muser, Fabien Squara, Deviprasad Venugopal, Pasquale Santangeli, David S Frankel, Erica S Zado, Francis E Marchlinski, David J Callans
PURPOSE: Frequent ventricular premature depolarizations (VPDs) may cause cardiomyopathy (VPDCM), which often improves after VPD suppression. This study aimed to evaluate whether ablation of outflow tract ventricular arrhythmias (OT VAs) in patients with VPDCM improves renal in addition to left ventricular (LV) function. METHODS: We retrospectively evaluated 153 patients with OT VAs and examined VPD burden and LV ejection fraction (LVEF), as well as estimated glomerular filtration rate (eGFR) pre- and post-ablation...
October 10, 2016: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
https://www.readbyqxmd.com/read/27705889/impact-of-proximal-cap-ambiguity-on-outcomes-of-chronic-total-occlusion-percutaneous-coronary-intervention-insights-from-a-multicenter-us-registry
#4
Aris Karatasakis, Barbara A Danek, Dimitri Karmpaliotis, Khaldoon Alaswad, Farouc A Jaffer, Robert W Yeh, Mitul P Patel, John N Bahadorani, R Michael Wyman, William L Lombardi, J Aaron Grantham, David E Kandzari, Nicholas J Lembo, Anthony H Doing, Jeffrey W Moses, Ajay J Kirtane, Santiago Garcia, Manish A Parikh, Ziad A Ali, Judit Karacsonyi, Sanjog Kalra, Bavana V Rangan, Pratik Kalsaria, Craig A Thompson, Subhash Banerjee, Emmanouil S Brilakis
OBJECTIVES: We sought to determine the impact of proximal cap ambiguity on procedural techniques and outcomes for coronary chronic total occlusion (CTO) percutaneous coronary intervention (PCI). METHODS: We examined the clinical and angiographic characteristics and outcomes of 1021 CTO-PCIs performed between 2012 and 2015 at 11 United States centers. RESULTS: Proximal cap ambiguity was present in 31% of target lesions and was associated with increased clinical and angiographic complexity (prior coronary artery bypass graft surgery: 43% vs 33%; P=...
October 2016: Journal of Invasive Cardiology
https://www.readbyqxmd.com/read/27650660/attributable-harm-of-severe-bleeding-after-cardiac-surgery-in-hemodynamically-stable-patients
#5
J Trent Magruder, Stephen Belmustakov, Rika Ohkuma, Sarah Collica, Joshua C Grimm, Todd Crawford, John V Conte, William A Baumgartner, Ashish S Shah, Glenn R Whitman
BACKGROUND: We sought to quantify the effect of severe postoperative bleeding in hemodynamically stable patients following cardiac surgery. METHODS: We reviewed the charts of all cardiac surgery patients operated on at our institution between 2010 and 2014. After excluding patients with tamponade or MAP <60, we propensity matched patients having chest tube output >300 mL in the first postoperative hour, >200 mL in the second, and >100 mL in the third ("bleeding" group) with patients having <50 mL/h of chest tube output ("dry" group)...
September 20, 2016: General Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/27627580/functional-changes-after-recombinant-human-growth-hormone-replacement-in-patients-with-chronic-traumatic-brain-injury-and-abnormal-growth-hormone-secretion
#6
Kurt A Mossberg, William J Durham, Dennis J Zgaljardic, Charles R Gilkison, Christopher P Danesi, Melinda Sheffield-Moore, Brent E Masel, Randall J Urban
We explored the effects of recombinant human growth hormone (rhGH) replacement on physical and cognitive functioning in subjects with a moderate-to-severe traumatic brain injury (TBI) with abnormal growth hormone (GH) secretion. Fifteen individuals who sustained a TBI at least 12 months prior to study enrollment were identified as having abnormal GH secretion by glucagon stimulation testing (maximum GH response less than 8 ng/mL). Peak cardiorespiratory capacity, body composition, and muscle force testing were assessed at baseline and one year after rhGH replacement...
October 13, 2016: Journal of Neurotrauma
https://www.readbyqxmd.com/read/27609201/healthy-aging-does-not-compromise-the-augmentation-of-cardiac-function-during-heat-stress
#7
Daniel Gagnon, Steven A Romero, Hai Ngo, Satyam Sarma, William K Cornwell, Paula Y S Poh, Douglas Stoller, Benjamin D Levine, Craig G Crandall
During heat stress, stroke volume is maintained in young adults despite reductions in cardiac filling pressures. This is achieved by a general augmentation of cardiac function, highlighted by a left and upward shift of the Frank-Starling relation. In contrast, healthy aged adults are unable to maintain stroke volume during heat stress. We hypothesized that this would be associated with a lack of shift in the Frank-Starling relation. Frank-Starling relations were examined in 11 aged [69 ± 4 (SD) yr, 4 men/7 women] and 12 young (26 ± 5 yr, 6 men/6 women) adults during normothermic and heat stress (1...
October 1, 2016: Journal of Applied Physiology
https://www.readbyqxmd.com/read/27578897/coagulation-parameter-thresholds-associated-with-non-bleeding-in-the-eighth-hour-of-adult-cardiac-surgical-post-cardiotomy-extracorporeal-membrane-oxygenation
#8
Jeffrey B Riley, Gregory J Schears, Gregory A Nuttall, William C Oliver, Mark H Ereth, Joseph A Dearani
Excessive bleeding and allogeneic transfusion during adult post-cardiotomy venoarterial extracorporeal membrane oxygenation (ECMO) are potentially harmful and expensive. Balancing the inhibition of clotting and distinguishing surgical from non-surgical bleeding in post-operative period is difficult. The sensitivity of coagulation tests including Thromboelastography(®) (TEG) to predict chest tube drainage in the early hours of ECMO was examined with the use of receiver-operating characteristics (ROC). The results are useful to incorporate in clinical evidence-based algorithms to guide management decisions...
June 2016: Journal of Extra-corporeal Technology
https://www.readbyqxmd.com/read/27562972/induction-of-therapeutic-hypothermia-during-out-of-hospital-cardiac-arrest-using-a-rapid-infusion-of-cold-saline-the-rinse-trial-rapid-infusion-of-cold-normal-saline
#9
Stephen A Bernard, Karen Smith, Judith Finn, Cindy Hein, Hugh Grantham, Janet E Bray, Conor Deasy, Michael Stephenson, Teresa A Williams, Lahn D Straney, Deon Brink, Richard Larsen, Chris Cotton, Peter Cameron
BACKGROUND: Patients successfully resuscitated by paramedics from out-of-hospital cardiac arrest often have severe neurologic injury. Laboratory and observational clinical reports have suggested that induction of therapeutic hypothermia during cardiopulmonary resuscitation (CPR) may improve neurologic outcomes. One technique for induction of mild therapeutic hypothermia during CPR is a rapid infusion of large-volume cold crystalloid fluid. METHODS: In this multicenter, randomized, controlled trial we assigned adults with out-of-hospital cardiac arrest undergoing CPR to either a rapid intravenous infusion of up to 2 L of cold saline or standard care...
September 13, 2016: Circulation
https://www.readbyqxmd.com/read/27530134/the-impact-of-moderate-distance-recreational-running-and-ageing-on-cardiac-physiology
#10
Jonathan H Kim, Yi-An Ko, Jeff Hedley, James MacNamara, Mosaab Awad, William Taylor, Sean Healy, Hiroshi Aida, Ngoc-Anh Le, Peter W Wilson, Melissa White, Laurence S Sperling, Joseph S Wilson, Aaron L Baggish
OBJECTIVE: Exercise-induced cardiac dysfunction and corollary biomarker release have been documented following long-distance running events. To what degree these processes occur during shorter distance running events is unknown. METHODS: 72 healthy recreational runners (54% male/46% female) recruited by age (group 1 (18-20 years old, N=19); group 2 (45-50 years old, N=27); group 3 (70-75 years old, N=26)) were studied with echocardiography and biochemical profiling during participation in a 10 km running race...
August 16, 2016: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/27523775/albuminuria-kidney-function-and-sudden-cardiac-death-findings-from-the-reasons-for-geographic-and-racial-differences-in-stroke-regards-study
#11
Rajat Deo, Yulia A Khodneva, Michael G Shlipak, Elsayed Z Soliman, Suzanne E Judd, William M McClellan, Todd M Brown, J David Rhodes, Orlando M Gutiérrez, Sanjiv J Shah, Christine M Albert, Monika M Safford
BACKGROUND: Moderate-to-severe kidney disease increases risk for sudden cardiac death (SCD). Limited studies have evaluated how mild degrees of kidney dysfunction impact SCD risk. OBJECTIVE: The purpose of this study was to evaluate the association of albuminuria, which is one of the earliest biomarkers of kidney injury, and SCD. METHODS: The Reasons for Geographic and Racial Differences in Stroke (REGARDS) study is a prospective, population-based cohort of U...
August 11, 2016: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/27501853/pilot-trial-of-intravenous-lipid-emulsion-treatment-for-severe-nifedipine-induced-shock
#12
Christine M Murphy, Cliff Williams, Michael E Quinn, Brian Nicholson, Thomas Shoe, Michael C Beuhler, William P Kerns
Animal studies and human case reports show promise in using lipid rescue to treat refractory calcium channel antagonist toxicity. However, the majority of research and clinical experience has focused on non-dihydropyridine agents. Thus, we sought to investigate the value of lipid emulsion (ILE) therapy for dihydropyridine-induced shock. This IACUC-approved study utilized seven swine that were sedated with alpha-chloralose, mechanically ventilated, and instrumented for drug delivery and hemodynamic measures...
December 2016: Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology
https://www.readbyqxmd.com/read/27471206/high-attenuation-areas-on-chest-computed-tomography-in-community-dwelling-adults-the-mesa-study
#13
Anna J Podolanczuk, Elizabeth C Oelsner, R Graham Barr, Eric A Hoffman, Hilary F Armstrong, John H M Austin, Robert C Basner, Matthew N Bartels, Jason D Christie, Paul L Enright, Bernadette R Gochuico, Karen Hinckley Stukovsky, Joel D Kaufman, P Hrudaya Nath, John D Newell, Scott M Palmer, Dan Rabinowitz, Ganesh Raghu, Jessica L Sell, Jered Sieren, Sushil K Sonavane, Russell P Tracy, Jubal R Watts, Kayleen Williams, Steven M Kawut, David J Lederer
Evidence suggests that lung injury, inflammation and extracellular matrix remodelling precede lung fibrosis in interstitial lung disease (ILD). We examined whether a quantitative measure of increased lung attenuation on computed tomography (CT) detects lung injury, inflammation and extracellular matrix remodelling in community-dwelling adults sampled without regard to respiratory symptoms or smoking.We measured high attenuation areas (HAA; percentage of lung voxels between -600 and -250 Hounsfield Units) on cardiac CT scans of adults enrolled in the Multi-Ethnic Study of Atherosclerosis...
November 2016: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/27334015/computed-tomography-myocardial-perfusion-vs-15-o-water-positron-emission-tomography-and-fractional-flow-reserve
#14
Michelle C Williams, Saeed Mirsadraee, Marc R Dweck, Nicholas W Weir, Alison Fletcher, Christophe Lucatelli, Tom MacGillivray, Saroj K Golay, Nicholas L Cruden, Peter A Henriksen, Neal Uren, Graham McKillop, João A C Lima, John H Reid, Edwin J R van Beek, Dilip Patel, David E Newby
OBJECTIVES: Computed tomography (CT) can perform comprehensive cardiac imaging. We compared CT coronary angiography (CTCA) and CT myocardial perfusion (CTP) with (15)O-water positron emission tomography (PET) and invasive coronary angiography (ICA) with fractional flow reserve (FFR). METHODS: 51 patients (63 (61-65) years, 80 % male) with known/suspected coronary artery disease (CAD) underwent 320-multidetector CTCA followed by "snapshot" adenosine stress CTP. Of these 22 underwent PET and 47 ICA/FFR...
June 22, 2016: European Radiology
https://www.readbyqxmd.com/read/27267867/cardiovascular-disease-and-10-year-mortality-in-postmenopausal-women-with-clinical-features-of-polycystic-ovary-syndrome
#15
C Noel Bairey Merz, Leslee J Shaw, Ricardo Azziz, Frank Z Stanczyk, George Sopko, Glenn D Braunstein, Sheryl F Kelsey, Kevin E Kip, Rhonda M Cooper-DeHoff, B Delia Johnson, Viola Vaccarino, Steven E Reis, Vera Bittner, T Keta Hodgson, William Rogers, Carl J Pepine
BACKGROUND: Women with polycystic ovary syndrome (PCOS) have greater cardiac risk factor clustering but the link with mortality is incompletely described. OBJECTIVE: To evaluate outcomes in 295 postmenopausal women enrolled in the National Institutes of Health-National Heart, Lung, and Blood Institute (NIH-NHLBI) sponsored Women's Ischemia Syndrome Evaluation (WISE) study according to clinical features of PCOS. MATERIALS AND METHODS: A total of 25/295 (8%) women had clinical features of PCOS defined by a premenopausal history of irregular menses and current biochemical evidence of hyperandrogenemia, defined as the top quartile of androstenedione (≥701 pg/mL), testosterone (≥30...
September 2016: Journal of Women's Health
https://www.readbyqxmd.com/read/27236005/use-of-saphenous-vein-bypass-grafts-for-retrograde-recanalization-of-coronary-chronic-total-occlusions-insights-from-a-multicenter-registry
#16
Phuong-Khanh J Nguyen-Trong, Khaldoon Alaswad, Dimitri Karmpaliotis, William Lombardi, J Aaron Grantham, Nicholas Lembo, David Kandzari, Aris Karatasakis, Judit Karacsonyi, Barbara A Danek, Bavana V Rangan, Michele Roesle, Colby R Ayers, Craig A Thompson, Subhash Banerjee, Emmanouil S Brilakis
BACKGROUND: The use of saphenous vein grafts (SVGs) for retrograde native-vessel chronic total occlusion (CTO) percutaneous coronary intervention (PCI) has received limited study. METHODS: We retrospectively reviewed the medical records and coronary angiograms of retrograde CTO-PCI performed through an SVG at four United States institutions between 2012 and 2013. RESULTS: During the study period, retrograde CTO-PCI was performed in 144 of 572 cases (25...
June 2016: Journal of Invasive Cardiology
https://www.readbyqxmd.com/read/27162614/unexplained-exertional-dyspnea-caused-by-low-ventricular-filling-pressures-results-from-clinical-invasive-cardiopulmonary-exercise-testing
#17
William M Oldham, Gregory D Lewis, Alexander R Opotowsky, Aaron B Waxman, David M Systrom
To determine whether low ventricular filling pressures are a clinically relevant etiology of unexplained dyspnea on exertion, a database of 619 consecutive, clinically indicated invasive cardiopulmonary exercise tests (iCPETs) was reviewed to identify patients with low maximum aerobic capacity (V̇o2max) due to inadequate peak cardiac output (Qtmax) with normal biventricular ejection fractions and without pulmonary hypertension (impaired: n = 49, V̇o2max = 53% predicted [interquartile range (IQR): 47%-64%], Qtmax = 72% predicted [62%-76%])...
March 2016: Pulmonary Circulation
https://www.readbyqxmd.com/read/27086771/impact-of-temperature-on-porcine-liver-machine-perfusion-from-donors-after-cardiac-death
#18
Ahmed Nassar, Qiang Liu, Kevin Farias, Laura Buccini, William Baldwin, Ana Bennett, Martin Mangino, Samuel Irefin, Jacek Cywinski, Toshihiro Okamoto, Teresa Diago Uso, Giuseppe Iuppa, Basem Soliman, Charles Miller, Cristiano Quintini
Normothermic machine perfusion (NMP) has been introduced as a promising technology to preserve and possibly repair marginal liver grafts. The aim of this study was to compare the effect of temperature on the preservation of donation after cardiac death (DCD) liver grafts in an ex vivo perfusion model after NMP (38.5°C) and subnormothermic machine perfusion (SNMP, 21°C) with a control group preserved by cold storage (CS, 4°C). Fifteen porcine livers with 60 min of warm ischemia were preserved for 10 h by NMP, SNMP or CS (n = 5/group)...
April 18, 2016: Artificial Organs
https://www.readbyqxmd.com/read/26973756/effects-of-intraosseous-tibial-vs-intravenous-vasopressin-in-a-hypovolemic-cardiac-arrest-model
#19
Justin Fulkerson, Robert Lowe, Tristan Anderson, Heather Moore, William Craig, Don Johnson
INTRODUCTION: This study compared the effects of vasopressin via tibial intraosseous (IO) and intravenous (IV) routes on maximum plasma concentration (Cmax), the time to maximum concentration (Tmax), return of spontaneous circulation (ROSC), and time to ROSC in a hypovolemic cardiac arrest model. METHODS: This study was a randomized prospective, between-subjects experimental design. A computer program randomly assigned 28 Yorkshire swine to one of four groups: IV (n=7), IO tibia (n=7), cardiopulmonary resuscitation (CPR) + defibrillation (n=7), and a control group that received just CPR (n=7)...
March 2016: Western Journal of Emergency Medicine
https://www.readbyqxmd.com/read/26782941/dual-kidney-transplants-from-adult-marginal-donors-successfully-expand-the-limited-deceased-donor-organ-pool
#20
Robert J Stratta, Alan C Farney, Giuseppe Orlando, Umar Farooq, Yousef Al-Shraideh, Amudha Palanisamy, Amber Reeves-Daniel, William Doares, Scott Kaczmorski, Michael D Gautreaux, Samy S Iskandar, Gloria Hairston, Elizabeth Brim, Margaret Mangus, Hany El-Hennawy, Muhammad Khan, Jeffrey Rogers
BACKGROUND: The need to expand the organ donor pool remains a formidable challenge in kidney transplantation (KT). The use of expanded criteria donors (ECDs) represents one approach, but kidney discard rates are high because of concerns regarding overall quality. Dual KT (DKT) may reduce organ discard and optimize the use of kidneys from marginal donors. STUDY DESIGN: We conducted a single-center retrospective review of outcomes in adult recipients of DKTs from adult marginal deceased donors (DD) defined by limited renal functional capacity...
April 2016: Clinical Transplantation
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