keyword
https://read.qxmd.com/read/38467589/association-of-perioperative-transfusion-of-fresh-frozen-plasma-and-outcomes-after-cardiac-surgery
#1
JOURNAL ARTICLE
Jake V Hinton, Zhongyue Xing, Calvin Fletcher, Luke A Perry, Alexandra Karamesinis, Jenny Shi, Jahan C Penny-Dimri, Dhruvesh Ramson, Tim G Coulson, Reny Segal, Julian A Smith, Jenni Williams-Spence, Laurence Weinberg, Rinaldo Bellomo
BACKGROUND: Fresh frozen plasma (FFP) transfusion is used to manage coagulopathy and bleeding in cardiac surgery patients despite uncertainty about its safety and effectiveness. METHODS: We performed a propensity score matched analysis of the Australian and New Zealand Society of Cardiac and Thoracic Surgeons National Cardiac Surgery Database including patients from 39 centres from 2005 to 2018. We investigated the association of perioperative FFP transfusion with mortality and other clinical outcomes...
March 11, 2024: Acta Anaesthesiologica Scandinavica
https://read.qxmd.com/read/38448259/electrocardiographic-patterns-and-clinical-outcomes-of-acute-coronary-syndrome-cardiogenic-shock-in-patients-undergoing-percutaneous-coronary-intervention-a-propensity-score-analysis
#2
JOURNAL ARTICLE
Nicholas D'Elia, Sara Vogrin, Angela L Brennan, Diem Dinh, Jeffrey Lefkovits, Christopher M Reid, Dion Stub, Jason Bloom, Kawa Haji, Samer Noaman, David M Kaye, Nicholas Cox, William Chan
OBJECTIVES: To determine the influence of presenting electrocardiographic (ECG) changes on prognosis in acute coronary syndrome cardiogenic shock (ACS-CS) patients undergoing percutaneous coronary angiography (PCI). BACKGROUND: The effect of initial ECG changes such as ST-elevation myocardial infarction (STEMI) versus non-STEMI among patients ACS-CS on prognosis remains unclear. METHODS: We analysed data from consecutive patients with ACS-CS enrolled in the Victorian Cardiac Outcomes registry between 2014 and 2020...
March 4, 2024: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://read.qxmd.com/read/38363650/increased-left-ventricular-remodelling-index-in-paradoxical-low-flow-severe-aortic-stenosis-with-preserved-left-ventricular-ejection-fraction-compared-to-normal-flow-severe-aortic-stenosis
#3
JOURNAL ARTICLE
Jinghao Nicholas Ngiam, Nicholas Chew, Eric Jou, Jamie Sy Ho, Thanawin Pramotedham, Tze Sian Liong, Ivandito Kuntjoro, Tiong-Cheng Yeo, Ching-Hui Sia, William Kok Fai Kong, Kian-Keong Poh
INTRODUCTION: Patients with paradoxical low-flow (LF) severe aortic stenosis (AS) despite preserved left ventricular ejection fraction (LVEF) appear distinct from normal-flow (NF) patients, showing worse prognosis, more concentric hypertrophy and smaller left ventricular (LV) cavities. The left ventricular remodelling index (LVRI) has been demonstrated to reliably discriminate between physiologically adapted athlete's heart and pathological LV remodelling. METHODS: We studied patients with index echocardiographic diagnosis of severe AS (aortic valve area <1 cm2) with preserved LVEF (>50%)...
February 16, 2024: Singapore Medical Journal
https://read.qxmd.com/read/38360919/left-atrial-strain-in-multisystem-inflammatory-syndrome-in-children-and-associations-with-systemic-inflammation-and-cardiac-injury
#4
JOURNAL ARTICLE
Bryan M Jepson, Matthew Beaver, John L Colquitt, Dongngan T Truong, Hillary Crandall, Carol McFarland, Richard Williams, Zhining Ou, Devri Jensen, L LuAnn Minich, Edem Binka
Multisystem inflammatory syndrome in children (MIS-C) commonly involves cardiac injury with both systolic and diastolic dysfunction. Left atrial strain (LAS) detects subclinical diastolic dysfunction in adults but is infrequently used in children. We evaluated LAS in MIS-C and the associations with systemic inflammation and cardiac injury. In this retrospective cohort study, LAS parameters [reservoir (LAS-r), conduit (LAS-cd), and contractile (LAS-ct)] obtained from admission echocardiograms of MIS-C patients were compared to healthy controls and between MIS-C patients with and without cardiac injury (BNP > 500 pg/ml or troponin-I > 0...
February 15, 2024: Pediatric Cardiology
https://read.qxmd.com/read/38281215/baseline-echocardiography-and-laboratory-findings-in-mis-c-and-associations-with-clinical-illness-severity
#5
JOURNAL ARTICLE
Matthew Beaver, Bryan Jepson, Edem Binka, Dongngan Truong, Hillary Crandall, Carol McFarland, Richard Williams, Zhining Ou, Erin Treemarcki, Devri Jensen, L LuAnn Minich, John L Colquitt
Children with COVID-associated multisystem inflammatory syndrome (MIS-C) may develop severe disease. We explored the association of admission echocardiographic and laboratory parameters with MIS-C disease severity. This retrospective, single center study of consecutive MIS-C patients (4/2020-12/2021) excluded those with preexisting cardiomyopathy, congenital heart disease, or prior cardiotoxic therapy. Our hypothesis was that worse admission echocardiographic and laboratory parameters were associated with more severe disease based on vasoactive medication use...
January 28, 2024: Pediatric Cardiology
https://read.qxmd.com/read/38278825/improving-the-precision-of-shock-resuscitation-by-predicting-fluid-responsiveness-with-machine-learning-and-arterial-blood-pressure-waveform-data
#6
JOURNAL ARTICLE
Chitrabhanu B Gupta, Debraj Basu, Timothy K Williams, Lucas P Neff, Michael A Johnson, Nathan T Patel, Aravindh S Ganapathy, Magan R Lane, Fatemeh Radaei, Chen-Nee Chuah, Jason Y Adams
Fluid bolus therapy (FBT) is fundamental to the management of circulatory shock in critical care but balancing the benefits and toxicities of FBT has proven challenging in individual patients. Improved predictors of the hemodynamic response to a fluid bolus, commonly referred to as a fluid challenge, are needed to limit non-beneficial fluid administration and to enable automated clinical decision support and patient-specific precision critical care management. In this study we retrospectively analyzed data from 394 fluid boluses from 58 pigs subjected to either hemorrhagic or distributive shock...
January 26, 2024: Scientific Reports
https://read.qxmd.com/read/38232077/platelet-versus-fresh-frozen-plasma-transfusion-for-coagulopathy-in-cardiac-surgery-patients
#7
JOURNAL ARTICLE
Jake V Hinton, Calvin M Fletcher, Luke A Perry, Noah Greifer, Jessica N Hinton, Jenni Williams-Spence, Reny Segal, Julian A Smith, Christopher M Reid, Laurence Weinberg, Rinaldo Bellomo
BACKGROUND: Platelets (PLTS) and fresh frozen plasma (FFP) are often transfused in cardiac surgery patients for perioperative bleeding. Their relative effectiveness is unknown. METHODS: We conducted an entropy-weighted retrospective cohort study using the Australian and New Zealand Society of Cardiac and Thoracic Surgeons National Cardiac Surgery Database. All adults undergoing cardiac surgery between 2005-2021 across 58 sites were included. The primary outcome was operative mortality...
2024: PloS One
https://read.qxmd.com/read/38212185/extracorporeal-carbon-dioxide-removal-to-de-escalate-venovenous-extracorporeal-membrane-oxygenation-in-severe-covid-19-acute-respiratory-distress-syndrome
#8
JOURNAL ARTICLE
Gaetano Cambria, Audrey E Spelde, Salim E Olia, Mauer Biscotti, Emily Mackay, Michael Ibrahim, Marisa Cevasco, Christian Bermudez, William Vernick, Jacob Gutsche, Asad A Usman
OBJECTIVES: In a subset of patients with COVID-19 acute respiratory distress syndrome (ARDS), there is a need for extracorporeal membrane oxygenation (ECMO) for pulmonary support. The primary extracorporeal support tool for severe COVID-19 ARDS is venovenous (VV) ECMO; however, after hypoxemic respiratory failure resolves, many patients experience refractory residual hypercarbic respiratory failure. Extracorporeal carbon dioxide removal (ECCO2 R) for isolated hypercarbic type II respiratory failure can be used in select cases to deescalate patients from VV ECMO while the lung recovers the ability to exchange CO2 ...
March 2024: Journal of Cardiothoracic and Vascular Anesthesia
https://read.qxmd.com/read/38151488/biological-sex-does-not-influence-the-peak-cardiac-output-response-to-twelve-weeks-of-sprint-interval-training
#9
JOURNAL ARTICLE
William Bostad, Jennifer S Williams, Emily K Van Berkel, Douglas L Richards, Maureen J MacDonald, Martin J Gibala
Sprint interval training (SIT) increases peak oxygen uptake (V̇O2peak ) but the mechanistic basis is unclear. We have reported that 12 wk of SIT increased V̇O2peak and peak cardiac output (Q̇peak ) and the changes in these variables were correlated. An exploratory analysis suggested that Q̇peak increased in males but not females. The present study incorporated best practices to examine the potential influence of biological sex on the Q̇peak response to SIT. Male and female participants (n = 10 each; 21 ± 4 y) performed 33 ± 2 sessions of SIT over 12 wk...
December 27, 2023: Scientific Reports
https://read.qxmd.com/read/38054555/limited-versus-full-sternotomy-for-aortic-valve-replacement
#10
REVIEW
Bilal H Kirmani, Sion G Jones, Andrew Muir, S Chris Malaisrie, Darryl A Chung, Richard Jnn Williams, Enoch Akowuah
BACKGROUND: Aortic valve disease is a common condition easily treatable with cardiac surgery. This is conventionally performed by opening the sternum ('median sternotomy') and replacing the valve under cardiopulmonary bypass. Median sternotomy is well tolerated, but as less invasive options become available, the efficacy of limited incisions has been called into question. In particular, the effects of reducing the visibility and surgical access have raised safety concerns with regard to the placement of cannulae, venting of the heart, epicardial wire placement, and de-airing of the heart at the end of the procedure...
December 6, 2023: Cochrane Database of Systematic Reviews
https://read.qxmd.com/read/37969655/physical-activity-during-breast-cancer%C3%A2-therapy-associates-with-preserved-exercise-capacity-and-cardiac%C3%A2-function-wf97415
#11
JOURNAL ARTICLE
Moriah P Bellissimo, Justin M Canada, Jennifer H Jordan, Amy C Ladd, Kerryn W Reding, Tonya L Moore, William O Ntim, Emily M Heiston, Peter Brubaker, Shannon L Mihalko, Ralph D'Agostino, Nate O'Connell, Bonnie Ky, Lynne I Wagner, Mary Helen Hackney, Kathryn E Weaver, Glenn J Lesser, Nancy E Avis, Arnethea L Sutton, Alexander R Lucas, R Lee Franco, Bernard F Fuemmeler, Fadi N Salloum, W Gregory Hundley
BACKGROUND: Cancer treatment increases cardiovascular disease risk, but physical activity (PA) may prevent cardiovascular disease. OBJECTIVES: This study examined whether greater PA was associated with better submaximal exercise capacity and cardiac function during cancer therapy. METHODS: Participants included 223 women with stage I to III breast cancer (BC) before and 3 months after undergoing treatment and 126 control participants...
October 2023: JACC CardioOncology
https://read.qxmd.com/read/37953144/predictors-of-oliguria-in-post-traumatic-acute-kidney-injury
#12
JOURNAL ARTICLE
William B Risinger, Samuel J Pera, Kelsey E Cage, Matthew V Benns, Nicholas A Nash, Matthew C Bozeman, Jamie C Coleman, Glen A Franklin, Keith R Miller, Jason W Smith, Brian G Harbrecht
BACKGROUND: Acute kidney injury is classified by urine output into non-oliguric and oliguric variants. Non-oliguric acute kidney injury has lower morbidity and mortality and accounts for up to 64% of acute kidney injury in hospitalized patients. However, the incidence of non-oliguric acute kidney injury in the trauma population and whether the 2 variants of acute kidney injury share the same risk factors is unknown. We hypothesized that oliguria would be present in the majority of acute kidney injury in severely injured trauma patients and that unique risk factors would predispose patients to the development of oliguria...
November 10, 2023: Surgery
https://read.qxmd.com/read/37942627/cardiac-reverse-remodeling-and-changes-in-heart-failure-indices-after-transcatheter-tricuspid-valve-replacement-in-adults-with-congenital-heart-disease
#13
JOURNAL ARTICLE
Abdalla A Salama, Omar A Abozied, Jason H Anderson, William R Miranda, Heidi M Connolly, Charles Jain, Allison Cabalka, Alexander C Egbe
BACKGROUND: There are limited data about changes in cardiac function (cardiac reverse remodeling) and heart failure indices after transcatheter tricuspid valve-in-valve replacement (TT-VIVR). The purpose of this study was to evaluate cardiac reverse remodeling and temporal changes in heart failure indices after TT-VIVR in adults with congenital heart disease. METHODS: Retrospective cohort study of adults with congenital heart disease that underwent TT-VIVR and had >6 months of follow-up (January 1, 2011, to April 30, 2023)...
November 9, 2023: Circulation. Cardiovascular Interventions
https://read.qxmd.com/read/37930776/transfemoral-tricuspid-valve-replacement-and-one-year-outcomes-the-triscend-study
#14
JOURNAL ARTICLE
Susheel Kodali, Rebecca T Hahn, Raj Makkar, Moody Makar, Charles J Davidson, Jyothy J Puthumana, Firas Zahr, Scott Chadderdon, Neil Fam, Geraldine Ong, Pradeep Yadav, Vinod Thourani, Mani A Vannan, William W O'Neill, Dee Dee Wang, Didier Tchétché, Nicolas Dumonteil, Laurent Bonfils, Laurent Lepage, Robert Smith, Paul A Grayburn, Rahul P Sharma, Christiane Haeffele, Vasilis Babaliaros, Patrick T Gleason, Sammy Elmariah, Ignacio Inglessis-Azuaje, Jonathan Passeri, Howard C Herrmann, Frank E Silvestry, Scott Lim, Dale Fowler, John G Webb, Robert Moss, Thomas Modine, Stephane Lafitte, Azeem Latib, Edwin Ho, Ythan Goldberg, Pinak Shah, Charles Nyman, Josep Rodés-Cabau, Elisabeth Bédard, Nicolas Brugger, Anna Sannino, Michael J Mack, Martin B Leon, Stephan Windecker
BACKGROUND AND AIMS: For patients with symptomatic, severe tricuspid regurgitation (TR), early results of transcatheter tricuspid valve (TV) intervention studies have shown significant improvements in functional status and quality of life associated with right-heart reverse remodelling. Longer-term follow-up is needed to confirm sustained improvements in these outcomes. METHODS: The prospective, single-arm, multicentre TRISCEND study enrolled 176 patients to evaluate the safety and performance of transcatheter TV replacement in patients with ≥moderate, symptomatic TR despite medical therapy...
December 7, 2023: European Heart Journal
https://read.qxmd.com/read/37772933/attenuating-intrathoracic-pressure-swings-decreases-cardiac-output-at-different-intensities-of-exercise
#15
JOURNAL ARTICLE
Sarah A Angus, Joshua L Taylor, Leah M Mann, Alexandra M Williams, Eric J Stöhr, Jason S Au, Andrew William Sheel, Paolo B Dominelli
Intrathoracic pressure (ITP) swings that permit spontaneous ventilation have physiological implications for the heart. We sought to determine the effect of respiration on cardiac output ( <mml:math xmlns:mml="https://www.w3.org/1998/Math/MathML"> <mml:semantics><mml:mover><mml:mi>Q</mml:mi> <mml:mo>̇</mml:mo></mml:mover> <mml:annotation>$\dot Q$</mml:annotation></mml:semantics> </mml:math> ) during semi-supine cycle exercise using a proportional assist ventilator to minimize ITP changes and lower the work of breathing (Wb )...
September 29, 2023: Journal of Physiology
https://read.qxmd.com/read/37729618/neurocognitive-impairment-associated-with-chronic-morbidity-in-long-term-survivors-of-hodgkin-lymphoma
#16
JOURNAL ARTICLE
Nicholas Steve Phillips, Daniel A Mulrooney, AnnaLynn M Williams, Wei Liu, Raja B Khan, Matthew Ehrhardt, Tim Folse, Matthew J Krasin, Deo Kumar S Srivastava, Kirsten K Ness, Melissa M Hudson, Noah D Sabin, Kevin R Krull
Thoracic radiation is associated with significant cardiopulmonary morbidities in long-term Hodgkin lymphoma (HL) survivors and may impact neurocognitive outcomes. Survivors (N=204, 52.5% female, mean[SD] age 36.6[8.01] years), treated with thoracic radiation, and age-, sex- and race/ethnicity-matched community controls (N=205, 51.7% female, age 36.7[9.17] years) completed standardized neurocognitive testing, echocardiography, pulmonary function tests, and vascular studies during the same visit. Treatments were abstracted from medical records...
September 20, 2023: Blood Advances
https://read.qxmd.com/read/37647308/paying-attention-to-cardiac-surgical-risk-an-interpretable-machine-learning-approach-using-an-uncertainty-aware-attentive-neural-network
#17
JOURNAL ARTICLE
Jahan C Penny-Dimri, Christoph Bergmeir, Christopher M Reid, Jenni Williams-Spence, Andrew D Cochrane, Julian A Smith
Machine learning (ML) is increasingly applied to predict adverse postoperative outcomes in cardiac surgery. Commonly used ML models fail to translate to clinical practice due to absent model explainability, limited uncertainty quantification, and no flexibility to missing data. We aimed to develop and benchmark a novel ML approach, the uncertainty-aware attention network (UAN), to overcome these common limitations. Two Bayesian uncertainty quantification methods were tested, generalized variational inference (GVI) or a posterior network (PN)...
2023: PloS One
https://read.qxmd.com/read/37632493/cardiopulmonary-performance-among%C3%A2-heart%C3%A2-failure-patients-before-and%C3%A2-after-left-ventricular-assist-device%C3%A2-implantation
#18
JOURNAL ARTICLE
Cole Buchanan, Collen Buchanan, Maeveen Riordan, Jessica Byrd, Margaret Schulte, Wendy M Kohrt, Amrut V Ambardekar, Larry A Allen, Gene Wolfel, Justin Lawley, Benjamin D Levine, William K Cornwell
BACKGROUND: Patients with heart failure with reduced ejection fraction (HFrEF) have persistent impairments in functional capacity after continuous-flow left ventricular assist device (CF-LVAD) implantation. OBJECTIVES: This study aims to characterize longitudinal changes in exercise hemodynamics and functional capacity among patients with HFrEF before and after CF-LVAD implantation. METHODS: Ten patients underwent 3 invasive cardiopulmonary exercise tests on upright cycle ergometry with pulmonary artery catheterization: 1) Visit 1 before CF-LVAD implantation; 2) Visit 2 after device implantation with CF-LVAD pump speed held constant at baseline speed; and 3) Visit 3 with increases in pump speed during exercise (median: 1,050 rpm [IQR: 750-1,150 rpm] and 220 rpm [IQR: 120-220 rpm] for Heartmate 3 and Heartware VAD, respectively)...
August 7, 2023: JACC. Heart Failure
https://read.qxmd.com/read/37500394/real-world-long-term-survival-after-non-emergent-percutaneous-coronary-intervention-to-unprotected-left-main-coronary-artery-from-the-melbourne-interventional-group-mig-registry
#19
JOURNAL ARTICLE
Julian Gin, Julian Yeoh, Garry Hamilton, Andrew Ajani, Diem Dinh, Angela Brennan, Christopher M Reid, Melanie Freeman, Ernesto Oqueli, Chin Hiew, Dion Stub, William Chan, Sandra Picardo, Matias Yudi, Mark Horrigan, Omar Farouque, David Clark
BACKGROUND: Current evidence suggests that percutaneous coronary intervention for unprotected left main coronary artery disease (LMPCI) in selected patients is a safe alternative to coronary artery bypass grafting. However, real-world long-term survival data is limited. METHODS: We analyzed 24,644 patients from the MIG (Melbourne Interventional Group) registry between 2005 and 2020. We compared baseline clinical and procedural characteristics, in-hospital and 30-day outcomes, and long-term survival between unprotected LMPCI and non-LMPCI among patients without ST-segment elevation myocardial infarction, cardiogenic shock, or cardiac arrest...
July 18, 2023: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://read.qxmd.com/read/37492161/tree-based-survival-analysis-improves-mortality-prediction-in-cardiac-surgery
#20
JOURNAL ARTICLE
Jahan C Penny-Dimri, Christoph Bergmeir, Christopher M Reid, Jenni Williams-Spence, Luke A Perry, Julian A Smith
OBJECTIVES: Machine learning (ML) classification tools are known to accurately predict many cardiac surgical outcomes. A novel approach, ML-based survival analysis, remains unstudied for predicting mortality after cardiac surgery. We aimed to benchmark performance, as measured by the concordance index (C-index), of tree-based survival models against Cox proportional hazards (CPH) modeling and explore risk factors using the best-performing model. METHODS: 144,536 patients with 147,301 surgery events from the Australian and New Zealand Society of Cardiac and Thoracic Surgeons (ANZSCTS) national database were used to train and validate models...
2023: Frontiers in Cardiovascular Medicine
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