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JOURNAL ARTICLE
Matthew W McMaster, Subo Dey, Tzvi Fishkin, Andy Wang, William H Frishman, Wilbert S Aronow
Long coronavirus disease (COVID) is the development or persistence of symptoms after an acute SARS-CoV-2 (COVID-19) infection. Fewer patients are developing acute COVID-19 infections, but patients with long COVID continue to have alarming long-term sequelae. Many cardiac magnetic resonance imaging studies show significant changes in cardiac structure after a COVID-19 infection, suggestive of an increased burden of many cardiovascular diseases, notably myocarditis. The pathophysiology of COVID-19 requires viral binding to angiotensin-converting enzyme 2 protein receptors throughout the body, which are upregulated by inflammation...
January 29, 2024: Cardiology in Review
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JOURNAL ARTICLE
Matthew Beaver, Bryan Jepson, Edem Binka, Dongngan Truong, Hillary Crandall, Carol McFarland, Richard Williams, Zhining Ou, Erin Treemarcki, Devri Jensen, L LuAnn Minich, John L Colquitt
Children with COVID-associated multisystem inflammatory syndrome (MIS-C) may develop severe disease. We explored the association of admission echocardiographic and laboratory parameters with MIS-C disease severity. This retrospective, single center study of consecutive MIS-C patients (4/2020-12/2021) excluded those with preexisting cardiomyopathy, congenital heart disease, or prior cardiotoxic therapy. Our hypothesis was that worse admission echocardiographic and laboratory parameters were associated with more severe disease based on vasoactive medication use...
January 28, 2024: Pediatric Cardiology
#23
REVIEW
Mariem A Sawan, Sindhu Prabakaran, Melroy D'Souza, Omid Behbahani-Nejad, Matthew E Gold, Byron Robinson Williams, Ozlem Bilen
Hypertrophic cardiomyopathy (HCM) is a common contemporary, treatable, genetic disorder that can be compatible with normal longevity. While current medical therapies are ubiquitous, they are limited by a lack of solid evidence, are often inadequate, poorly tolerated, and do not alter the natural disease course. As such, there has long been a need for effective, evidence-based, and targeted disease-modifying therapies for HCM. In this review, we redefine HCM as a treatable condition, evaluate current strategies for therapeutic intervention, and discuss novel myosin inhibitors...
January 2024: Clinical Cardiology
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JOURNAL ARTICLE
Matthew B Morton, Jeremy William, Peter M Kistler, Sandeep Prabhu, Hariharan Sugumar, Olivier Van Den Brink, Hitesh Patel, Justin Mariani, Aleksandr Voskoboinik
BACKGROUND: Pneumothorax is a well-recognized complication of cardiac implantable electronic device (CIED) insertion. While AP fluoroscopy alone is the most commonly imaging technique for subclavian or axillary access, caudal fluoroscopy (angle 40°) is routinely used at our institution. The caudal view provides additional separation of the first rib and clavicle and may reduce the risk of pneumothorax. We assessed outcomes at our institution of AP and caudal fluoroscopic guided pacing lead insertion...
January 11, 2024: Journal of Cardiovascular Electrophysiology
#25
JOURNAL ARTICLE
Daniel A Gold, Pratik B Sandesara, Vardhmaan Jain, Matthew E Gold, Nishant Vatsa, Shivang R Desai, Malika Elhage Hassan, Chenyang Yuan, Yi-An Ko, Kiran Ejaz, Zain Alvi, Wissam A Jaber, William J Nicholson, Arshed A Quyyumi
BACKGROUND: Although a chronic total occlusion (CTO) in the setting of an acute coronary syndrome is associated with higher risk, the prognosis of patients with stable CAD and CTOs remains unknown. OBJECTIVES: To investigate adverse event rates in patients with stable CAD with and without a CTO. METHODS: In 3597 patients with stable CAD (>50% coronary luminal stenosis) undergoing cardiac catheterization, all-cause mortality, cardiovascular mortality and the composite major adverse cardiac event (MACE) rates for cardiovascular death, myocardial infarction and heart failure hospitalization were evaluated...
January 7, 2024: American Journal of Cardiology
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JOURNAL ARTICLE
Kamil Polok, Bruce M Biccard, Matthew T V Chan, R Andrew Archbold, Chew Yin Wang, Alben Sigamani, Gerard Urrútia, Patricia Cruz, Sadeesh K Srinathan, David Szalay, John Harlock, Jacques G Tittley, Fadi Elias, Michael J Jacka, German Malaga, Otavio Berwanger, Dorota Studzińska, Jacek Górka, Félix R Montes, Clara K Chow, Gareth L Ackland, Luc Dubois, Robert J Sapsford, Colin Williams, Olga L Cortés, P J Devereaux, Wojciech Szczeklik
INTRODUCTION: Patients undergoing vascular procedures are prone to developing postoperative complications affecting short-term mortality. Prospective reports describing the incidence of long-term complications after vascular surgery are lacking. OBJECTIVES: We aimed to describe the incidence of one-year complications after vascular surgery and to evaluate an association between myocardial injury after noncardiac surgery (MINS) and one-year mortality. PATIENTS AND METHODS: This is a substudy of a large prospective cohort study - Vascular Events in Noncardiac Surgery Patients Cohort Evaluation (VISION)...
January 2, 2024: Polish Archives of Internal Medicine
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RANDOMIZED CONTROLLED TRIAL
Christopher A Rajkumar, Michael J Foley, Fiyyaz Ahmed-Jushuf, Alexandra N Nowbar, Florentina A Simader, John R Davies, Peter D O'Kane, Peter Haworth, Helen Routledge, Tushar Kotecha, Reto Gamma, Gerald Clesham, Rupert Williams, Jehangir Din, Sukhjinder S Nijjer, Nick Curzen, Neil Ruparelia, Manas Sinha, Jason N Dungu, Sashiananthan Ganesananthan, Ramzi Khamis, Lal Mughal, Tim Kinnaird, Ricardo Petraco, James C Spratt, Sayan Sen, Joban Sehmi, David J Collier, Afzal Sohaib, Thomas R Keeble, Graham D Cole, James P Howard, Darrel P Francis, Matthew J Shun-Shin, Rasha K Al-Lamee
BACKGROUND: Percutaneous coronary intervention (PCI) is frequently performed to reduce the symptoms of stable angina. Whether PCI relieves angina more than a placebo procedure in patients who are not receiving antianginal medication remains unknown. METHODS: We conducted a double-blind, randomized, placebo-controlled trial of PCI in patients with stable angina. Patients stopped all antianginal medications and underwent a 2-week symptom assessment phase before randomization...
December 21, 2023: New England Journal of Medicine
#28
JOURNAL ARTICLE
Yuemeng Feng, William Worstell, Matthew Kupinski, Lars R Furenlid, Hamid Sabet
The Dynamic Cardiac SPECT (DC-SPECT) system is being developed at the Massachusetts General Hospital, featuring a static cardio-focus asymmetrical geometry enabling simultaneous high-resolution and high-sensitivity imaging. Among 14 design iterations of the DC-SPECT with varying number of detector heads, system sensitivity and resolution, the version under development features 10 mm FWHM geometrical resolution (without resolution recovery) and 0.07% sensitivity at the FOV center, this is 1.5x resolution gain and 7x sensitivity gain compared to a conventional dual-head gamma camera (0...
November 23, 2023: Biomedical Physics & Engineering Express
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JOURNAL ARTICLE
Alexander J Skojec, Jon M Christensen, Suraj M Yalamuri, Mark M Smith, Arman Arghami, Allison M LeMahieu, Darrell R Schroeder, William J Mauermann, Gregory A Nuttall, Matthew J Ritter
OBJECTIVE: To examine the analgesic efficacy of postoperative deep parasternal intercostal plane (DPIP) blocks for patients having cardiac surgery via median sternotomy. DESIGN: This single-center retrospective study compared patients receiving bilateral DPIP blocks with a matched cohort of patients not receiving DPIP blocks. SETTING: Large quaternary referral center. PARTICIPANTS: Adult patients admitted to the authors' institution from January 1, 2016, to August 14, 2020, for elective cardiac surgery via median sternotomy...
October 4, 2023: Journal of Cardiothoracic and Vascular Anesthesia
#30
JOURNAL ARTICLE
William B Risinger, Samuel J Pera, Kelsey E Cage, Matthew V Benns, Nicholas A Nash, Matthew C Bozeman, Jamie C Coleman, Glen A Franklin, Keith R Miller, Jason W Smith, Brian G Harbrecht
BACKGROUND: Acute kidney injury is classified by urine output into non-oliguric and oliguric variants. Non-oliguric acute kidney injury has lower morbidity and mortality and accounts for up to 64% of acute kidney injury in hospitalized patients. However, the incidence of non-oliguric acute kidney injury in the trauma population and whether the 2 variants of acute kidney injury share the same risk factors is unknown. We hypothesized that oliguria would be present in the majority of acute kidney injury in severely injured trauma patients and that unique risk factors would predispose patients to the development of oliguria...
November 10, 2023: Surgery
#31
REVIEW
Brahmajee K Nallamothu, Robert Greif, Theresa Anderson, Huba Atiq, Thomaz Bittencourt Couto, Julie Considine, Allan R De Caen, Therese Djärv, Ann Doll, Matthew J Douma, Dana P Edelson, Feng Xu, Judith C Finn, Grace Firestone, Saket Girotra, Kasper G Lauridsen, Carrie Kah-Lai Leong, Swee Han Lim, Peter T Morley, Laurie J Morrison, Ari Moskowitz, Ajit Mullasari Sankardas, Mahmoud Tageldin Mustafa Mohamed, Michelle Christy Myburgh, Vinay M Nadkarni, Robert W Neumar, Jerry P Nolan, Justine Athieno Odakha, Theresa M Olasveengen, Judit Orosz, Gavin D Perkins, Jeanette K Previdi, Christian Vaillancourt, William H Montgomery, Comilla Sasson, Paul S Chan
No abstract text is available yet for this article.
November 10, 2023: Circulation. Cardiovascular Quality and Outcomes
#32
JOURNAL ARTICLE
Paul S Chan, Robert Greif, Theresa Anderson, Huba Atiq, Thomaz Bittencourt Couto, Julie Considine, Allan R De Caen, Therese Djärv, Ann Doll, Matthew J Douma, Dana P Edelson, Feng Xu, Judith C Finn, Grace Firestone, Saket Girotra, Kasper G Lauridsen, Carrie Kah-Lai Leong, Swee Han Lim, Peter T Morley, Laurie J Morrison, Ari Moskowitz, Ajit Mullasari Sankardas, Mahmoud Tageldin Mustafa Mohamed, Michelle Christy Myburgh, Vinay M Nadkarni, Robert W Neumar, Jerry P Nolan, Justine Athieno Odakha, Theresa M Olasveengen, Judit Orosz, Gavin D Perkins, Jeanette K Previdi, Christian Vaillancourt, William H Montgomery, Comilla Sasson, Brahmajee K Nallamothu
No abstract text is available yet for this article.
December 2023: Resuscitation
#33
JOURNAL ARTICLE
Alexander Sharp, Gareth Matthews, Nikolaos Papageorgiou, Richard Till, Daniel Raine, Ian Williams, Cairistine Grahame-Clarke, Santosh Nair, Omar Abdul-Samad, Vassilios Vassiliou, Pankaj Garg, Wei Yao Lim
BACKGROUND: Permanent pacemaker (PPM) implantation is a well-established treatment for symptomatic sinus node dysfunction (SND). The optimal timing of this intervention is unclear, with atrioventricular blocks often prioritized in resource stressed waiting lists due to mortality concerns. METHODS: Mortality data was compared between patients receiving elective outpatient (OP) PPM implantation, and those presenting to hospital for urgent inpatient (IP) management for symptomatic SND...
November 1, 2023: Pacing and Clinical Electrophysiology: PACE
#34
JOURNAL ARTICLE
Cole B Hirschfeld, Sharmila Dorbala, Leslee J Shaw, Todd C Villines, Andrew D Choi, Nathan Better, Rodrigo J Cerci, Ganesan Karthikeyan, João V Vitola, Michelle C Williams, Mouaz Al-Mallah, Daniel S Berman, Adam Bernheim, Robert W Biederman, Paco E Bravo, Matthew J Budoff, Renee P Bullock-Palmer, Marcus Y Chen, Michael P DiLorenzo, Rami Doukky, Maros Ferencik, Jeffrey B Geske, Fadi G Hage, Robert C Hendel, Lynne Koweek, Venkatesh L Murthy, Jagat Narula, Patricia F Rodriguez Lozano, Nishant R Shah, Amee Shah, Prem Soman, Randall C Thompson, David Wolinsky, Yosef A Cohen, Eli Malkovskiy, Michael J Randazzo, Juan Lopez-Mattei, Purvi Parwani, Mrinali Shetty, Thomas N B Pascual, Yaroslav Pynda, Maurizio Dondi, Diana Paez, Andrew J Einstein
PURPOSE: To characterize the recovery of diagnostic cardiovascular procedure volumes in U.S. and non-U.S. facilities in the year following the initial COVID-19 outbreak. MATERIALS AND METHODS: The International Atomic Energy Agency (IAEA) coordinated a worldwide study called the IAEA Noninvasive Cardiology Protocols Study of COVID-19 2 (INCAPS COVID 2), collecting data from 669 facilities in 107 countries, including 93 facilities in 34 U.S. states, to determine the impact of the pandemic on diagnostic cardiovascular procedure volumes...
October 2023: Radiology. Cardiothoracic imaging
#35
REVIEW
Matthew F Yuyun, Jacob Joseph, Sebhat A Erqou, Scott Kinlay, Justin B Echouffo-Tcheugui, Adelqui O Peralta, Peter S Hoffmeister, William E Boden, Hirad Yarmohammadi, David T Martin, Jagmeet P Singh
Cardiac resynchronization therapy (CRT) significantly reduces secondary mitral regurgitation (MR) in patients with severe left ventricular systolic dysfunction. However, uncertainty remains as to whether improvement in secondary MR correlates with improvement with mortality seen in CRT. We conducted a meta-analysis to determine the association of persistent unimproved significant secondary MR (defined as moderate or moderate-to-severe or severe MR) compared to improved MR (no MR or mild MR) post-CRT with all-cause mortality, cardiovascular mortality, and heart failure hospitalization...
October 19, 2023: Heart Failure Reviews
#36
JOURNAL ARTICLE
Mark A Fogel, Elizabeth Donnelly, Ian Crandell, Alex Hanlon, Kevin K Whitehead, Matthew Harris, Sara Partington, David Biko, Thomas Flynn, Susan Nicolson, J William Gaynor, Daniel Licht, Arastoo Vossough
Patients with a single ventricle develop aortopulmonary collaterals (APCs) whose flow has been shown to be inversely proportional to cerebral blood flow (CBF) in a previous cross-sectional study. Longitudinal CBF and APC flow in patients with Fontan physiology adjusting for brain injury (BI) has never been reported. Decreased CBF and BI may adversely impact neurodevelopment. A prospective longitudinal cohort of 27 patients with Fontan physiology (aged 10 ± 1.9 years, 74% male) underwent cardiac and brain magnetic resonance imaging 3 to 9 months and 6...
October 14, 2023: American Journal of Cardiology
#37
JOURNAL ARTICLE
Damilola Idowu, Zachary Gray, Matthew Stanton, William Rushton, David Gummin
INTRODUCTION: For many years, the standard of care in the USA has been to treat acute lead encephalopathy with a combination parenteral dimercaprol (BAL) and CaNa2 EDTA. We present a case of a pediatric patient with severe lead encephalopathy, complicated by cardiac arrest, who was treated with an alternative regimen when CaNa2 EDTA was unavailable. CASE REPORT: A 24-month-old male was brought by ambulance to an emergency department (ED) with new onset seizures and sustained a cardiac arrest...
October 16, 2023: Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology
#38
JOURNAL ARTICLE
Tae Jin Park, Ryan Hansen, Patrick Gillard, Darshini Shah, William G Ferguson, Jonathan Piccini, Matthew A Romano, Beth Devine
BACKGROUND: Postoperative atrial fibrillation (POAF) is one of the most common complications following cardiac surgery. POAF is associated with increased hospitalization costs, but its long-term economic burden is not well defined. OBJECTIVE: To assess 30-day and 1-year incremental healthcare resource utilization (HRU) and costs associated with POAF in the United States (US). METHODS: This retrospective cohort study used claims data from the IBM Watson MarketScan database...
October 6, 2023: Journal of Medical Economics
#39
Frazer Kirk, Matthew S Yong, Peter Williams, Andrie Stroebel
Pulmonary valve (PV) fibroelastomas are a rare pathology, with limited anecdotal literature surrounding them. Consequently, the natural history is unclear; however, two features have remained salient; they are asymptomatic and found incidentally. Here, we describe a 52-year-old female, presenting with symptoms suggestive pulmonary embolism (PE). Pulmonary angiography revealed a filling deficit in the pulmonary trunk (PT), adjacent to the PV. Subsequent investigation found a large PV fibroelastoma. The presence of symptoms is likely secondary to right ventricular outflow tract obstruction from the lesions large size...
September 2023: Journal of Surgical Case Reports
#40
REVIEW
Mina Ghobrial, Bilal Bawamia, Timothy Cartlidge, Ioakim Spyridopoulos, Vijay Kunadian, Azfar Zaman, Mohaned Egred, Adam McDiarmid, Matthew Williams, Mohamed Farag, Mohammad Alkhalil
Microvascular obstruction (MVO) is a recognised phenomenon following mechanical reperfusion in patients presenting with ST-segment elevation myocardial infarction (STEMI). Invasive and non-invasive modalities to detect and measure the extent of MVO vary in their accuracy, suggesting that this phenomenon may reflect a spectrum of pathophysiological changes at the level of coronary microcirculation. The importance of detecting MVO lies in the observation that its presence adds incremental risk to patients following STEMI treatment...
September 13, 2023: Journal of Clinical Medicine
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